- Yale Medical OncologySmilow Cancer Hospital at Yale New Haven35 Park Street, Ste 7th Floor Multispecialty Care CenterNew Haven, CT 06511
Stuart Seropian, MD
Biography
Stuart Seropian, MD, is a medical oncologist who specializes in treating patients with blood cancers, including acute and chronic leukemia, non-Hodgkin’s lymphoma, and multiple myeloma. Dr. Seropian also sees patients with non-cancerous bone marrow disorders, including aplastic anemia. He is director of the adult Stem Cell Transplant program and co-director of the CAR T-cell Therapy Program for adults.
In medical school, Dr. Seropian enjoyed studying the biology of cancer and wanted to provide long-term patient care, which led to his pursuing medical oncology. “I have patients who see me as their primary care physician—as the doctor most responsible for their long-term care,” Dr. Seropian says. “Patients will say they’ve experienced a physician who had one foot out the door before all questions were answered. But the relationship with the patient is vital for cancer treatment.”
During his career, Dr. Seropian has witnessed treatment options for patients with blood cancers improve by leaps and bounds, from chemotherapy to the personalized CAR T-cell and stem cell transplantation therapies.
“The general view among the public is that cancer is terminal,” Dr. Seropian says. “People are always surprised to hear that cure rates [for certain cancers] range from 30 to 65 percent.”
He points out that a transplant physician is one of many providers of care in a large cast, which includes other physician subspecialists, nurse practitioners, nurses, coordinators, laboratory physicians and technicians. “Patients who come here are cared for by a family of people,” he says.
Dr. Seropian is an associate professor of medicine (hematology) at Yale School of Medicine.
Titles
- Professor of Internal Medicine (Hematology)
- Acting Director, Stem Cell Transplantation
- Chairman, Car-T Cell Joint Steering Committee
- Director, Unrelated Donor Transplant Program, Stem Cell Transplantation
- Co-Director, Immune Effector Cell Therapy
- Co-Director, Adult CAR T-Cell Therapy Program
Education & Training
- ResidentYale-New Haven Hospital (1994)
- InternYale-New Haven Hospital (1992)
- MDGeorge Washington University (1991)
- BSTufts University (1984)
Additional Information
- Yale Cancer Center Award for Clinical Excellence: Yale Cancer Center (2016)
- David S. Fischer Annual Award for Outstanding Teaching and Mentoring of Fellows in Hematology: Yale Cancer Center (2014)
- Alpha Omega Alpha Medical Honor Society: AOA (1991)
- MD with Distinction, George Washington University School of Medicine: George Washington University School of Medicine (1991)
- Horowitz Award, NBME Part I: George Washington University School of Medicine (1989)
- Hodgkin’s Lymphoma Guidelines Panel, National Comprehensive Cancer Center Network (2016 - Present): Committee Member
- EMR User Group, Center for International Blood and Marrow Transplantation Research (CIBMTR) (2014 - Present): Member
- Bone Marrow Transplantation (2014 - Present): Ad Hoc Reviewer of journal submissions
- Transfusion (2014 - Present): Reviewer
- Search Committee, Chair of Pulmonary Section, Department of Medicine (2008 - 2010): Member
- Education Review Committee (2007 - 2008): Member
- Internship Selection Committee (2006 - 2007): Member
- The Bone Marrow Foundation (2001 - Present): Regular participant in public access patient/family online advice query activities.
- Protocol Review Committee (1999 - 2017): review all clinical research protocols submitted for scientific review in the Cancer Center prior to IRB submission
- Avery J, Chandhok N, Rainey C, Torres R, Huntington S, Isufi I, Seropian S, Xu ML, Foss F. Peripheral Blood Involvement at Staging in Patients With Aggressive Peripheral T-Cell Lymphoma. Clinical Lymphoma, Myeloma & Leukemia 2022, 22: 680-689. PMID: 35568635, DOI: 10.1016/j.clml.2022.04.019.
- Shallis RM, Pucar D, Perincheri S, Gore SD, Seropian SE, Podoltsev NA, Zeidan AM. Molecular testing of isolated myeloid sarcoma allows successful FLT3-targeted therapy. Annals Of Hematology 2022, 101: 1145-1147. PMID: 34686913, DOI: 10.1007/s00277-021-04702-w.
- Bleakley M, Sehgal A, Seropian S, Biernacki MA, Krakow EF, Dahlberg A, Persinger H, Hilzinger B, Martin PJ, Carpenter PA, Flowers ME, Voutsinas J, Gooley TA, Loeb K, Wood BL, Heimfeld S, Riddell SR, Shlomchik WD. Naive T-Cell Depletion to Prevent Chronic Graft-Versus-Host Disease. Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology 2022, 40: 1174-1185. PMID: 35007144, PMCID: PMC8987226, DOI: 10.1200/JCO.21.01755.
- Hoppe RT, Advani RH, Ai WZ, Ambinder RF, Armand P, Bello CM, Benitez CM, Chen W, Dabaja B, Daly ME, Gordon LI, Hansen N, Herrera AF, Hochberg EP, Johnston PB, Kaminski MS, Kelsey CR, Kenkre VP, Khan N, Lynch RC, Maddocks K, McConathy J, Metzger M, Morgan D, Mulroney C, Pullarkat ST, Rabinovitch R, Rosenspire KC, Seropian S, Tao R, Torka P, Winter JN, Yahalom J, Yang JC, Burns JL, Campbell M, Sundar H. NCCN Guidelines® Insights: Hodgkin Lymphoma, Version 2.2022. Journal Of The National Comprehensive Cancer Network : JNCCN 2022, 20: 322-334. PMID: 35390768, DOI: 10.6004/jnccn.2022.0021.
- Bewersdorf JP, Derkach A, Gowda L, Menghrajani K, DeWolf S, Ruiz JD, Ponce DM, Shaffer BC, Tamari R, Young JW, Jakubowski AA, Gyurkocza B, Chan A, Xiao W, Glass J, King AC, Cai SF, Daniyan A, Famulare C, Cuello BM, Podoltsev NA, Roshal M, Giralt S, Perales MA, Seropian S, Cho C, Zeidan AM, Prebet T, Stein EM, Tallman MS, Goldberg AD, Stahl M. Venetoclax-based combinations in AML and high-risk MDS prior to and following allogeneic hematopoietic cell transplant. Leukemia & Lymphoma 2021, 62: 3394-3401. PMID: 34477024, PMCID: PMC9012492, DOI: 10.1080/10428194.2021.1966788.
- Gowda L, Seropian S. Life Expectancy After Allogeneic Stem Cell Transplant-In It for the Long Haul? JAMA Oncology 2021, 7: 1611-1613. PMID: 34499090, DOI: 10.1001/jamaoncol.2021.3674.
- Perreault S, Schiffer M, Clinchy-Jarmoszko V, Bocchetta N, Barbarotta L, Abdelghany O, Foss F, Huntington S, Seropian S, Isufi I. Mitigating the risk of COVID-19 exposure by transitioning from clinic-based to home-based immune globulin infusion. American Journal Of Health-system Pharmacy : AJHP : Official Journal Of The American Society Of Health-System Pharmacists 2021, 78: 1112-1117. PMID: 33617630, PMCID: PMC7929449, DOI: 10.1093/ajhp/zxab072.
- Gupta GK, Perreault S, Seropian SE, Tormey CA, Hendrickson JE. Optimization of repeat plerixafor dosing for autologous peripheral blood stem-cell collection. Transfusion And Apheresis Science : Official Journal Of The World Apheresis Association : Official Journal Of The European Society For Haemapheresis 2021, 60: 103069. PMID: 33546988, DOI: 10.1016/j.transci.2021.103069.
- Shallis RM, Bewersdorf JP, Swoboda DM, Wei W, Gowda L, Prebet T, Halene S, Pillai MM, Parker T, Neparidze N, Podoltsev NA, Seropian S, Sallman DA, Gore SD, Zeidan AM. Challenges in the Evaluation and Management of Toxicities Arising From Immune Checkpoint Inhibitor Therapy for Patients With Myeloid Malignancies. Clinical Lymphoma, Myeloma & Leukemia 2021, 21: e483-e487. PMID: 33551344, DOI: 10.1016/j.clml.2021.01.003.
- Shallis RM, Gale RP, Lazarus HM, Roberts KB, Xu ML, Seropian SE, Gore SD, Podoltsev NA. Myeloid sarcoma, chloroma, or extramedullary acute myeloid leukemia tumor: A tale of misnomers, controversy and the unresolved. Blood Reviews 2021, 47: 100773. PMID: 33213985, DOI: 10.1016/j.blre.2020.100773.
- Branagan AR, Duffy E, Gan G, Li F, Foster C, Verma R, Zhang L, Parker TL, Seropian S, Cooper DL, Brandt D, Kortmansky J, Witt D, Ferencz TM, Dhodapkar KM, Dhodapkar MV. Tandem high-dose influenza vaccination is associated with more durable serologic immunity in patients with plasma cell dyscrasias. Blood Advances 2021, 5: 1535-1539. PMID: 33683337, PMCID: PMC7948269, DOI: 10.1182/bloodadvances.2020003880.
- Sharma A, Bhatt NS, St Martin A, Abid MB, Bloomquist J, Chemaly RF, Dandoy C, Gauthier J, Gowda L, Perales MA, Seropian S, Shaw BE, Tuschl EE, Zeidan AM, Riches ML, Shah GL. Clinical characteristics and outcomes of COVID-19 in haematopoietic stem-cell transplantation recipients: an observational cohort study. The Lancet. Haematology 2021, 8: e185-e193. PMID: 33482113, PMCID: PMC7816949, DOI: 10.1016/S2352-3026(20)30429-4.
- Isufi I, Seropian S, Gowda L, Wilson LD, Roberts K, Girardi M, Perreault S, Foss F. Outcomes for allogeneic stem cell transplantation in refractory mycosis fungoides and primary cutaneous gamma Delta T cell lymphomas. Leukemia & Lymphoma 2020, 61: 2955-2961. PMID: 32643494, DOI: 10.1080/10428194.2020.1790555.
- Foss FM, Rubinowitz A, Landry ML, Isufi I, Gowda L, Seropian S, Perreault S, Shenoi SV. Attenuated Novel SARS Coronavirus 2 Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient on Ruxolitinib. Clinical Lymphoma, Myeloma & Leukemia 2020, 20: 720-723. PMID: 32727701, PMCID: PMC7316063, DOI: 10.1016/j.clml.2020.06.014.
- Price CC, Altice FL, Shyr Y, Koff A, Pischel L, Goshua G, Azar MM, Mcmanus D, Chen SC, Gleeson SE, Britto CJ, Azmy V, Kaman K, Gaston DC, Davis M, Burrello T, Harris Z, Villanueva MS, Aoun-Barakat L, Kang I, Seropian S, Chupp G, Bucala R, Kaminski N, Lee AI, LoRusso PM, Topal JE, Dela Cruz C, Malinis M. Tocilizumab Treatment for Cytokine Release Syndrome in Hospitalized Patients With Coronavirus Disease 2019: Survival and Clinical Outcomes. Chest 2020, 158: 1397-1408. PMID: 32553536, PMCID: PMC7831876, DOI: 10.1016/j.chest.2020.06.006.
- Bewersdorf JP, Shallis RM, Gowda L, Wei W, Hager K, Isufi I, Kim TK, Pillai MM, Seropian S, Podoltsev NA, Gore SD, Siddon AJ, Zeidan AM. Clinical outcomes and characteristics of patients with TP53-mutated acute myeloid leukemia or myelodysplastic syndromes: a single center experience. Leukemia & Lymphoma 2020, 61: 2180-2190. PMID: 32362171, PMCID: PMC7603787, DOI: 10.1080/10428194.2020.1759051.
- Hoppe RT, Advani RH, Ai WZ, Ambinder RF, Armand P, Bello CM, Benitez CM, Bierman PJ, Boughan KM, Dabaja B, Gordon LI, Hernandez-Ilizaliturri FJ, Herrera AF, Hochberg EP, Huang J, Johnston PB, Kaminski MS, Kenkre VP, Khan N, Lynch RC, Maddocks K, McConathy J, McKinney M, Metzger M, Morgan D, Mulroney C, Rabinovitch R, Rosenspire KC, Seropian S, Tao R, Winter JN, Yahalom J, Burns JL, Ogba N. Hodgkin Lymphoma, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network : JNCCN 2020, 18: 755-781. PMID: 32502987, DOI: 10.6004/jnccn.2020.0026.
- Baker JK, Shank-Coviello J, Zhou B, Dixon J, McCorkle R, Sarpong D, Medoff E, Cooper D, Seropian S, Dai F. Cardiotoxicity in Hematopoietic Stem Cell Transplant: Keeping the Beat. Clinical Lymphoma, Myeloma & Leukemia 2020, 20: 244-251.e4. PMID: 32067953, DOI: 10.1016/j.clml.2019.12.027.
- Shallis RM, Gleeson S, Azar M, Malinis M, Xu ML, Seropian SE, Gowda L, Zeidan AM. Allogeneic stem cell transplantation and combination antiretroviral therapy: cautions, complications, and considerations. Leukemia & Lymphoma 2019, 60: 2584-2587. PMID: 30943051, DOI: 10.1080/10428194.2019.1594221.
- Perreault S, McManus D, Bar N, Foss F, Gowda L, Isufi I, Seropian S, Malinis M, Topal JE. The impact of a multimodal approach to vancomycin discontinuation in hematopoietic stem cell transplant recipients (HSCT) with febrile neutropenia (FN). Transplant Infectious Disease : An Official Journal Of The Transplantation Society 2019, 21: e13059. PMID: 30737868, DOI: 10.1111/tid.13059.
- Kim TK, DeVeaux M, Stahl M, Perreault S, Isufi I, Cooper D, Foss F, Shlomchik W, Zelterman D, Zeidan AM, Seropian S. Long-term follow-up of a single institution pilot study of sirolimus, tacrolimus, and short course methotrexate for graft versus host disease prophylaxis in mismatched unrelated donor allogeneic stem cell transplantation. Annals Of Hematology 2019, 98: 237-240. PMID: 30027436, DOI: 10.1007/s00277-018-3427-1.
- Hoppe RT, Advani RH, Ai WZ, Ambinder RF, Aoun P, Armand P, Bello CM, Benitez CM, Bierman PJ, Chen R, Dabaja B, Dean R, Forero A, Gordon LI, Hernandez-Ilizaliturri FJ, Hochberg EP, Huang J, Johnston PB, Kaminski MS, Kenkre VP, Khan N, Maddocks K, Maloney DG, Metzger M, Moore JO, Morgan D, Moskowitz CH, Mulroney C, Rabinovitch R, Seropian S, Tao R, Winter JN, Yahalom J, Burns JL, Ogba N. NCCN Guidelines Insights: Hodgkin Lymphoma, Version 1.2018. Journal Of The National Comprehensive Cancer Network : JNCCN 2018, 16: 245-254. PMID: 29523663, DOI: 10.6004/jnccn.2018.0013.
- Cyrenne BM, Gibson JF, Subtil A, Girardi M, Isufi I, Seropian S, Foss F. Transplantation in the Treatment of Primary Cutaneous Aggressive Epidermotropic Cytotoxic CD8-Positive T-Cell Lymphoma. Clinical Lymphoma, Myeloma & Leukemia 2018, 18: e85-e93. PMID: 29223388, DOI: 10.1016/j.clml.2017.11.004.
- Anderson A, McManus D, Perreault S, Lo YC, Seropian S, Topal JE. Combination liposomal amphotericin B, posaconazole and oral amphotericin B for treatment of gastrointestinal Mucorales in an immunocompromised patient. Medical Mycology Case Reports 2017, 17: 11-13. PMID: 28580237, PMCID: PMC5447657, DOI: 10.1016/j.mmcr.2017.05.004.
- Hoppe RT, Advani RH, Ai WZ, Ambinder RF, Aoun P, Bello CM, Benitez CM, Bernat K, Bierman PJ, Blum KA, Chen R, Dabaja B, Forero A, Gordon LI, Hernandez-Ilizaliturri FJ, Hochberg EP, Huang J, Johnston PB, Kaminski MS, Kenkre VP, Khan N, Maloney DG, Mauch PM, Metzger M, Moore JO, Morgan D, Moskowitz CH, Mulroney C, Poppe M, Rabinovitch R, Seropian S, Smith M, Winter JN, Yahalom J, Burns J, Ogba N, Sundar H. Hodgkin Lymphoma Version 1.2017, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network : JNCCN 2017, 15: 608-638. PMID: 28476741, DOI: 10.6004/jnccn.2017.0064.
- Branagan AR, Duffy E, Albrecht RA, Cooper DL, Seropian S, Parker TL, Gan G, Li F, Zelterman D, Boddupalli CS, Zhang L, Verma R, Ferencz TM, Dhodapkar MV. Clinical and Serologic Responses After a Two-dose Series of High-dose Influenza Vaccine in Plasma Cell Disorders: A Prospective, Single-arm Trial. Clinical Lymphoma, Myeloma & Leukemia 2017, 17: 296-304.e2. PMID: 28343904, PMCID: PMC5413398, DOI: 10.1016/j.clml.2017.02.025.
- Perreault S, Baker J, Medoff E, Pratt K, Foss F, Isufi I, Seropian S, Cooper DL. Infusion reactions are common after high-dose carmustine in BEAM chemotherapy and are not reduced by lengthening the time of administration. Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer 2017, 25: 205-208. PMID: 27614867, DOI: 10.1007/s00520-016-3399-4.
- Hur DJ, Dicks DL, Huber S, Mojibian HR, Meadows JL, Seropian SE, Baldassarre LA. Serial Native T1 Mapping to Monitor Cardiac Response to Treatment in Light-Chain Amyloidosis. Circulation. Cardiovascular Imaging 2016, 9 PMID: 27682238, DOI: 10.1161/CIRCIMAGING.116.004770.
- Cooper DL, Medoff E, Patel N, Baker J, Pratt K, Foss F, Seropian SE, Perreault S, Wu Y. Autologous Stem Cell Mobilization in the Age of Plerixafor. Clinical Lymphoma, Myeloma & Leukemia 2016, 16: 411-6. PMID: 27245311, DOI: 10.1016/j.clml.2016.04.007.
- Xu ML, Acevedo-Gadea C, Seropian S, Katz SG. Expression of CD30 as a biomarker to predict response to brentuximab vedotin. Histopathology 2016, 69: 155-8. PMID: 26648051, PMCID: PMC7064871, DOI: 10.1111/his.12914.
- Nadeau M, Perreault S, Seropian S, Foss F, Isufi I, Cooper DL. The use of basiliximab-infliximab combination for the treatment of severe gastrointestinal acute GvHD. Bone Marrow Transplantation 2016, 51: 273-6. PMID: 26479982, DOI: 10.1038/bmt.2015.247.
- Bleakley M, Heimfeld S, Loeb KR, Jones LA, Chaney C, Seropian S, Gooley TA, Sommermeyer F, Riddell SR, Shlomchik WD. Outcomes of acute leukemia patients transplanted with naive T cell-depleted stem cell grafts. The Journal Of Clinical Investigation 2015, 125: 2677-89. PMID: 26053664, PMCID: PMC4563691, DOI: 10.1172/JCI81229.
- Sehgal K, Das R, Zhang L, Verma R, Deng Y, Kocoglu M, Vasquez J, Koduru S, Ren Y, Wang M, Couto S, Breider M, Hansel D, Seropian S, Cooper D, Thakurta A, Yao X, Dhodapkar KM, Dhodapkar MV. Clinical and pharmacodynamic analysis of pomalidomide dosing strategies in myeloma: impact of immune activation and cereblon targets. Blood 2015, 125: 4042-51. PMID: 25869284, PMCID: PMC4481593, DOI: 10.1182/blood-2014-11-611426.
- Hoppe RT, Advani RH, Ai WZ, Ambinder RF, Aoun P, Bello CM, Benitez CM, Bierman PJ, Blum KA, Chen R, Dabaja B, Forero A, Gordon LI, Hernandez-Ilizaliturri FJ, Hochberg EP, Huang J, Johnston PB, Khan N, Maloney DG, Mauch PM, Metzger M, Moore JO, Morgan D, Moskowitz CH, Mulroney C, Poppe M, Rabinovitch R, Seropian S, Tsien C, Winter JN, Yahalom J, Burns JL, Sundar H. Hodgkin lymphoma, version 2.2015. Journal Of The National Comprehensive Cancer Network : JNCCN 2015, 13: 554-86. PMID: 25964641, PMCID: PMC4898052, DOI: 10.6004/jnccn.2015.0075.
- Cecchini M, Sznol M, Seropian S. Immune therapy of metastatic melanoma developing after allogeneic bone marrow transplant. Journal For Immunotherapy Of Cancer 2015, 3: 10. PMID: 25806109, PMCID: PMC4372324, DOI: 10.1186/s40425-015-0054-4.
- Gibson JF, Foss F, Cooper D, Seropian S, Irizarry D, Barbarotta L, Lansigan F. Pilot study of sorafenib in relapsed or refractory peripheral and cutaneous T-cell lymphoma. British Journal Of Haematology 2014, 167: 141-4. PMID: 24888971, DOI: 10.1111/bjh.12944.
- Crooks M, Seropian S, Bai M, McCorkle R. Monitoring patient distress and related problems before and after hematopoietic stem cell transplantation. Palliative & Supportive Care 2014, 12: 53-61. PMID: 24169207, DOI: 10.1017/S1478951513000552.
- Disorders of LymphocytesLacy J, Seropian, S, Disorders of Lymphocytes, Andreoli: in Cecil Essentials of Medicine, 9th ed. 2014
- Parker TL, Cooper DL, Seropian SE, Bolognia JL. Toxic erythema of chemotherapy following i.v. BU plus fludarabine for allogeneic PBSC transplant. Bone Marrow Transplantation 2013, 48: 646-50. PMID: 23165491, DOI: 10.1038/bmt.2012.218.
- Total-Body and HemiBody IrradiationRoberts K, Chen, Z, Seropian S. Total-Body and HemiBody Irradiation, Perez and Brady’s Principles and Practice of Radiation Oncology, Halperin E, Perez C, and Brady L eds. Sixth edition. 2013
- LymphomaIsufi I, Seropian S, Lymphoma, Oncology in Primary Care. Rose, MG, Devita VT, Lawrence TS, Rosenberg SA, 1st edition, 2013
- Plasma Cell DisordersSeropian S, Isufi I, Plasma Cell Disorders, Oncology in Primary Care. Rose, MG, Devita VT, Lawrence TS, Rosenberg SA, 1st edition, 2013
- LeukemiaRoberts K, Seropian S, Marks, P, Leukemia, Perez and Brady’s In Principles and Practice of Radiation Oncology, Halperin E, Perez C, and Brady L eds. Sixth edition. 2013
- Cooper DL, Proytcheva M, Medoff E, Seropian SE, Snyder EL, Krause DS, Wu Y. Successful collection and engraftment of autologous peripheral blood progenitor cells in poorly mobilized patients receiving high-dose granulocyte colony-stimulating factor. Journal Of Clinical Apheresis 2012, 27: 235-41. PMID: 22566214, DOI: 10.1002/jca.21232.
- Omer B, Kadan-Lottick NS, Roberts KB, Wang R, Demsky C, Kupfer GM, Cooper D, Seropian S, Ma X. Patterns of subsequent malignancies after Hodgkin lymphoma in children and adults. British Journal Of Haematology 2012, 158: 615-25. PMID: 22775513, DOI: 10.1111/j.1365-2141.2012.09211.x.
- Aslanian H, Chander B, Robert M, Cooper D, Proctor D, Seropian S, Jain D. Prospective evaluation of acute graft-versus-host disease. Digestive Diseases And Sciences 2012, 57: 720-5. PMID: 22011927, DOI: 10.1007/s10620-011-1938-x.
- King BA, Seropian S, Fox LP. Disseminated fusarium infection with muscle involvement. Journal Of The American Academy Of Dermatology 2011, 65: 235-7. PMID: 21679835, DOI: 10.1016/j.jaad.2009.12.034.
- Cooper DL, Pratt K, Baker J, Medoff E, Conkling-Walsh A, Foss F, Snyder E, Yen W, Seropian SE. Late afternoon dosing of plerixafor for stem cell mobilization: a practical solution. Clinical Lymphoma, Myeloma & Leukemia 2011, 11: 267-72. PMID: 21658654, DOI: 10.1016/j.clml.2011.03.014.
- Strout MP, Seropian S, Berliner N. Alemtuzumab as a bridge to allogeneic SCT in atypical hemophagocytic lymphohistiocytosis. Nature Reviews. Clinical Oncology 2010, 7: 415-20. PMID: 20404855, DOI: 10.1038/nrclinonc.2010.40.
- Chowdhury S, Seropian S, Marks PW. Decitabine combined with fractionated gemtuzumab ozogamicin therapy in patients with relapsed or refractory acute myeloid leukemia. American Journal Of Hematology 2009, 84: 599-600. PMID: 19650144, DOI: 10.1002/ajh.21478.
- Kassar M, Medoff E, Seropian S, Cooper DL. Outpatient high-dose melphalan in multiple myeloma patients. Transfusion 2007, 47: 115-9. PMID: 17207239, DOI: 10.1111/j.1537-2995.2007.01073.x.
- Schaffer JV, McNiff JM, Seropian S, Cooper DL, Bolognia JL. Lichen sclerosus and eosinophilic fasciitis as manifestations of chronic graft-versus-host disease: expanding the sclerodermoid spectrum. Journal Of The American Academy Of Dermatology 2005, 53: 591-601. PMID: 16198778, DOI: 10.1016/j.jaad.2005.06.015.
- Baehring J, Cooper D, Seropian S, Bannykh S. Images in neuro-oncology. Large B-cell lymphoma. Journal Of Neuro-oncology 2004, 67: 189. PMID: 15072466, DOI: 10.1023/b:neon.0000021952.37526.49.
- New Approaches to allografting in non-Hodgkin's lymphoma.Seropian S, Cooper DL. New Approaches to allografting in non-Hodgkin's lymphoma. Progress in Oncology, 2004 Jones and Bartlett.
- Lerro KA, Medoff E, Wu Y, Seropian SE, Snyder E, Krause D, Cooper DL. A simplified approach to stem cell mobilization in multiple myeloma patients not previously treated with alkylating agents. Bone Marrow Transplantation 2003, 32: 1113-7. PMID: 14647264, DOI: 10.1038/sj.bmt.1704286.
- Seropian S, Bahceci E, Cooper DL. Allogeneic peripheral blood stem cell transplantation for high-risk non-Hodgkin's lymphoma. Bone Marrow Transplantation 2003, 32: 763-9. PMID: 14520419, DOI: 10.1038/sj.bmt.1704233.
- Strasser SI, Shulman HM, Flowers ME, Reddy R, Margolis DA, Prumbaum M, Seropian SE, McDonald GB. Chronic graft-versus-host disease of the liver: presentation as an acute hepatitis. Hepatology (Baltimore, Md.) 2000, 32: 1265-71. PMID: 11093733, DOI: 10.1053/jhep.2000.20067.
- Debelak J, Shlomchik MJ, Snyder EL, Cooper D, Seropian S, McGuirk J, Smith B, Krause DS. Isolation and flow cytometric analysis of T-cell-depleted CD34+ PBPCs. Transfusion 2000, 40: 1475-81. PMID: 11134567, DOI: 10.1046/j.1537-2995.2000.40121475.x.
- Marshall NA, Howe JG, Formica R, Krause D, Wagner JE, Berliner N, Crouch J, Pilip I, Cooper D, Blazar BR, Seropian S, Pamer EG. Rapid reconstitution of Epstein-Barr virus-specific T lymphocytes following allogeneic stem cell transplantation. Blood 2000, 96: 2814-21. PMID: 11023516.
- Argiris A, Seropian S, Cooper DL. High-dose BEAM chemotherapy with autologous peripheral blood progenitor-cell transplantation for unselected patients with primary refractory or relapsed Hodgkin's disease. Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / ESMO 2000, 11: 665-72. PMID: 10942053, DOI: 10.1023/a:1008396525292.
- Autologous Stem Cell TransplantationCooper DL, Seropian S, Autologous Stem Cell Transplantation, in Principles and Practice of Oncology. Devita VT, Hellman S, Rosenberg S eds. 6th edition, 2000.
- Hodgkin's DiseaseSeropian S, Cooper DL. Hodgkin's Diseases in Annual of Lymphoid Malignancies. Cavelli F, Longo D eds. 2000
- McGuirk JP, Seropian S, Howe G, Smith B, Stoddart L, Cooper DL. Use of rituximab and irradiated donor-derived lymphocytes to control Epstein-Barr virus-associated lymphoproliferation in patients undergoing related haplo-identical stem cell transplantation. Bone Marrow Transplantation 1999, 24: 1253-8. PMID: 10642818, DOI: 10.1038/sj.bmt.1702052.
- Seropian S, Nadkarni R, Jillella AP, Salloum E, Burtness B, Hu GL, Zelterman D, Cooper DL. Neutropenic infections in 100 patients with non-Hodgkin's lymphoma or Hodgkin's disease treated with high-dose BEAM chemotherapy and peripheral blood progenitor cell transplant: out-patient treatment is a viable option. Bone Marrow Transplantation 1999, 23: 599-605. PMID: 10217191, DOI: 10.1038/sj.bmt.1701610.
- Seropian S, Ferguson D, Salloum E, Cooper D, Landry ML. Lack of reactivity to CMV pp65 antigenemia testing in a patient with CMV disease following allogeneic bone marrow transplant. Bone Marrow Transplantation 1998, 22: 507-9. PMID: 9733277, DOI: 10.1038/sj.bmt.1701354.
- McGuirk JP, Seropian S, Cooper D. HLA-mismatched family donor transplants: a novel strategy as curative therapy for patients with hematologic disorders. The Cancer Journal From Scientific American 1998, 4: 278-86. PMID: 9815289.
- Salloum E, Jillella AP, Nadkarni R, Seropian S, Hu GL, D'Andrea E, Zelterman D, Cooper DL. Assessment of pulmonary and cardiac function after high dose chemotherapy with BEAM and peripheral blood progenitor cell transplantation. Cancer 1998, 82: 1506-12. PMID: 9554528, DOI: 10.1002/(sici)1097-0142(19980415)82:8<1506::aid-cncr12>3.0.co;2-8.
- Yale Medical OncologySmilow Cancer Hospital at Yale New Haven35 Park Street, Ste 7th Floor Multispecialty Care CenterNew Haven, CT 06511
Biography
Stuart Seropian, MD, is a medical oncologist who specializes in treating patients with blood cancers, including acute and chronic leukemia, non-Hodgkin’s lymphoma, and multiple myeloma. Dr. Seropian also sees patients with non-cancerous bone marrow disorders, including aplastic anemia. He is director of the adult Stem Cell Transplant program and co-director of the CAR T-cell Therapy Program for adults.
In medical school, Dr. Seropian enjoyed studying the biology of cancer and wanted to provide long-term patient care, which led to his pursuing medical oncology. “I have patients who see me as their primary care physician—as the doctor most responsible for their long-term care,” Dr. Seropian says. “Patients will say they’ve experienced a physician who had one foot out the door before all questions were answered. But the relationship with the patient is vital for cancer treatment.”
During his career, Dr. Seropian has witnessed treatment options for patients with blood cancers improve by leaps and bounds, from chemotherapy to the personalized CAR T-cell and stem cell transplantation therapies.
“The general view among the public is that cancer is terminal,” Dr. Seropian says. “People are always surprised to hear that cure rates [for certain cancers] range from 30 to 65 percent.”
He points out that a transplant physician is one of many providers of care in a large cast, which includes other physician subspecialists, nurse practitioners, nurses, coordinators, laboratory physicians and technicians. “Patients who come here are cared for by a family of people,” he says.
Dr. Seropian is an associate professor of medicine (hematology) at Yale School of Medicine.
Titles
- Professor of Internal Medicine (Hematology)
- Acting Director, Stem Cell Transplantation
- Chairman, Car-T Cell Joint Steering Committee
- Director, Unrelated Donor Transplant Program, Stem Cell Transplantation
- Co-Director, Immune Effector Cell Therapy
- Co-Director, Adult CAR T-Cell Therapy Program
Education & Training
- ResidentYale-New Haven Hospital (1994)
- InternYale-New Haven Hospital (1992)
- MDGeorge Washington University (1991)
- BSTufts University (1984)
Additional Information
- Yale Cancer Center Award for Clinical Excellence: Yale Cancer Center (2016)
- David S. Fischer Annual Award for Outstanding Teaching and Mentoring of Fellows in Hematology: Yale Cancer Center (2014)
- Alpha Omega Alpha Medical Honor Society: AOA (1991)
- MD with Distinction, George Washington University School of Medicine: George Washington University School of Medicine (1991)
- Horowitz Award, NBME Part I: George Washington University School of Medicine (1989)
- Hodgkin’s Lymphoma Guidelines Panel, National Comprehensive Cancer Center Network (2016 - Present): Committee Member
- EMR User Group, Center for International Blood and Marrow Transplantation Research (CIBMTR) (2014 - Present): Member
- Bone Marrow Transplantation (2014 - Present): Ad Hoc Reviewer of journal submissions
- Transfusion (2014 - Present): Reviewer
- Search Committee, Chair of Pulmonary Section, Department of Medicine (2008 - 2010): Member
- Education Review Committee (2007 - 2008): Member
- Internship Selection Committee (2006 - 2007): Member
- The Bone Marrow Foundation (2001 - Present): Regular participant in public access patient/family online advice query activities.
- Protocol Review Committee (1999 - 2017): review all clinical research protocols submitted for scientific review in the Cancer Center prior to IRB submission
- Avery J, Chandhok N, Rainey C, Torres R, Huntington S, Isufi I, Seropian S, Xu ML, Foss F. Peripheral Blood Involvement at Staging in Patients With Aggressive Peripheral T-Cell Lymphoma. Clinical Lymphoma, Myeloma & Leukemia 2022, 22: 680-689. PMID: 35568635, DOI: 10.1016/j.clml.2022.04.019.
- Shallis RM, Pucar D, Perincheri S, Gore SD, Seropian SE, Podoltsev NA, Zeidan AM. Molecular testing of isolated myeloid sarcoma allows successful FLT3-targeted therapy. Annals Of Hematology 2022, 101: 1145-1147. PMID: 34686913, DOI: 10.1007/s00277-021-04702-w.
- Bleakley M, Sehgal A, Seropian S, Biernacki MA, Krakow EF, Dahlberg A, Persinger H, Hilzinger B, Martin PJ, Carpenter PA, Flowers ME, Voutsinas J, Gooley TA, Loeb K, Wood BL, Heimfeld S, Riddell SR, Shlomchik WD. Naive T-Cell Depletion to Prevent Chronic Graft-Versus-Host Disease. Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology 2022, 40: 1174-1185. PMID: 35007144, PMCID: PMC8987226, DOI: 10.1200/JCO.21.01755.
- Hoppe RT, Advani RH, Ai WZ, Ambinder RF, Armand P, Bello CM, Benitez CM, Chen W, Dabaja B, Daly ME, Gordon LI, Hansen N, Herrera AF, Hochberg EP, Johnston PB, Kaminski MS, Kelsey CR, Kenkre VP, Khan N, Lynch RC, Maddocks K, McConathy J, Metzger M, Morgan D, Mulroney C, Pullarkat ST, Rabinovitch R, Rosenspire KC, Seropian S, Tao R, Torka P, Winter JN, Yahalom J, Yang JC, Burns JL, Campbell M, Sundar H. NCCN Guidelines® Insights: Hodgkin Lymphoma, Version 2.2022. Journal Of The National Comprehensive Cancer Network : JNCCN 2022, 20: 322-334. PMID: 35390768, DOI: 10.6004/jnccn.2022.0021.
- Bewersdorf JP, Derkach A, Gowda L, Menghrajani K, DeWolf S, Ruiz JD, Ponce DM, Shaffer BC, Tamari R, Young JW, Jakubowski AA, Gyurkocza B, Chan A, Xiao W, Glass J, King AC, Cai SF, Daniyan A, Famulare C, Cuello BM, Podoltsev NA, Roshal M, Giralt S, Perales MA, Seropian S, Cho C, Zeidan AM, Prebet T, Stein EM, Tallman MS, Goldberg AD, Stahl M. Venetoclax-based combinations in AML and high-risk MDS prior to and following allogeneic hematopoietic cell transplant. Leukemia & Lymphoma 2021, 62: 3394-3401. PMID: 34477024, PMCID: PMC9012492, DOI: 10.1080/10428194.2021.1966788.
- Gowda L, Seropian S. Life Expectancy After Allogeneic Stem Cell Transplant-In It for the Long Haul? JAMA Oncology 2021, 7: 1611-1613. PMID: 34499090, DOI: 10.1001/jamaoncol.2021.3674.
- Perreault S, Schiffer M, Clinchy-Jarmoszko V, Bocchetta N, Barbarotta L, Abdelghany O, Foss F, Huntington S, Seropian S, Isufi I. Mitigating the risk of COVID-19 exposure by transitioning from clinic-based to home-based immune globulin infusion. American Journal Of Health-system Pharmacy : AJHP : Official Journal Of The American Society Of Health-System Pharmacists 2021, 78: 1112-1117. PMID: 33617630, PMCID: PMC7929449, DOI: 10.1093/ajhp/zxab072.
- Gupta GK, Perreault S, Seropian SE, Tormey CA, Hendrickson JE. Optimization of repeat plerixafor dosing for autologous peripheral blood stem-cell collection. Transfusion And Apheresis Science : Official Journal Of The World Apheresis Association : Official Journal Of The European Society For Haemapheresis 2021, 60: 103069. PMID: 33546988, DOI: 10.1016/j.transci.2021.103069.
- Shallis RM, Bewersdorf JP, Swoboda DM, Wei W, Gowda L, Prebet T, Halene S, Pillai MM, Parker T, Neparidze N, Podoltsev NA, Seropian S, Sallman DA, Gore SD, Zeidan AM. Challenges in the Evaluation and Management of Toxicities Arising From Immune Checkpoint Inhibitor Therapy for Patients With Myeloid Malignancies. Clinical Lymphoma, Myeloma & Leukemia 2021, 21: e483-e487. PMID: 33551344, DOI: 10.1016/j.clml.2021.01.003.
- Shallis RM, Gale RP, Lazarus HM, Roberts KB, Xu ML, Seropian SE, Gore SD, Podoltsev NA. Myeloid sarcoma, chloroma, or extramedullary acute myeloid leukemia tumor: A tale of misnomers, controversy and the unresolved. Blood Reviews 2021, 47: 100773. PMID: 33213985, DOI: 10.1016/j.blre.2020.100773.
- Branagan AR, Duffy E, Gan G, Li F, Foster C, Verma R, Zhang L, Parker TL, Seropian S, Cooper DL, Brandt D, Kortmansky J, Witt D, Ferencz TM, Dhodapkar KM, Dhodapkar MV. Tandem high-dose influenza vaccination is associated with more durable serologic immunity in patients with plasma cell dyscrasias. Blood Advances 2021, 5: 1535-1539. PMID: 33683337, PMCID: PMC7948269, DOI: 10.1182/bloodadvances.2020003880.
- Sharma A, Bhatt NS, St Martin A, Abid MB, Bloomquist J, Chemaly RF, Dandoy C, Gauthier J, Gowda L, Perales MA, Seropian S, Shaw BE, Tuschl EE, Zeidan AM, Riches ML, Shah GL. Clinical characteristics and outcomes of COVID-19 in haematopoietic stem-cell transplantation recipients: an observational cohort study. The Lancet. Haematology 2021, 8: e185-e193. PMID: 33482113, PMCID: PMC7816949, DOI: 10.1016/S2352-3026(20)30429-4.
- Isufi I, Seropian S, Gowda L, Wilson LD, Roberts K, Girardi M, Perreault S, Foss F. Outcomes for allogeneic stem cell transplantation in refractory mycosis fungoides and primary cutaneous gamma Delta T cell lymphomas. Leukemia & Lymphoma 2020, 61: 2955-2961. PMID: 32643494, DOI: 10.1080/10428194.2020.1790555.
- Foss FM, Rubinowitz A, Landry ML, Isufi I, Gowda L, Seropian S, Perreault S, Shenoi SV. Attenuated Novel SARS Coronavirus 2 Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient on Ruxolitinib. Clinical Lymphoma, Myeloma & Leukemia 2020, 20: 720-723. PMID: 32727701, PMCID: PMC7316063, DOI: 10.1016/j.clml.2020.06.014.
- Price CC, Altice FL, Shyr Y, Koff A, Pischel L, Goshua G, Azar MM, Mcmanus D, Chen SC, Gleeson SE, Britto CJ, Azmy V, Kaman K, Gaston DC, Davis M, Burrello T, Harris Z, Villanueva MS, Aoun-Barakat L, Kang I, Seropian S, Chupp G, Bucala R, Kaminski N, Lee AI, LoRusso PM, Topal JE, Dela Cruz C, Malinis M. Tocilizumab Treatment for Cytokine Release Syndrome in Hospitalized Patients With Coronavirus Disease 2019: Survival and Clinical Outcomes. Chest 2020, 158: 1397-1408. PMID: 32553536, PMCID: PMC7831876, DOI: 10.1016/j.chest.2020.06.006.
- Bewersdorf JP, Shallis RM, Gowda L, Wei W, Hager K, Isufi I, Kim TK, Pillai MM, Seropian S, Podoltsev NA, Gore SD, Siddon AJ, Zeidan AM. Clinical outcomes and characteristics of patients with TP53-mutated acute myeloid leukemia or myelodysplastic syndromes: a single center experience. Leukemia & Lymphoma 2020, 61: 2180-2190. PMID: 32362171, PMCID: PMC7603787, DOI: 10.1080/10428194.2020.1759051.
- Hoppe RT, Advani RH, Ai WZ, Ambinder RF, Armand P, Bello CM, Benitez CM, Bierman PJ, Boughan KM, Dabaja B, Gordon LI, Hernandez-Ilizaliturri FJ, Herrera AF, Hochberg EP, Huang J, Johnston PB, Kaminski MS, Kenkre VP, Khan N, Lynch RC, Maddocks K, McConathy J, McKinney M, Metzger M, Morgan D, Mulroney C, Rabinovitch R, Rosenspire KC, Seropian S, Tao R, Winter JN, Yahalom J, Burns JL, Ogba N. Hodgkin Lymphoma, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network : JNCCN 2020, 18: 755-781. PMID: 32502987, DOI: 10.6004/jnccn.2020.0026.
- Baker JK, Shank-Coviello J, Zhou B, Dixon J, McCorkle R, Sarpong D, Medoff E, Cooper D, Seropian S, Dai F. Cardiotoxicity in Hematopoietic Stem Cell Transplant: Keeping the Beat. Clinical Lymphoma, Myeloma & Leukemia 2020, 20: 244-251.e4. PMID: 32067953, DOI: 10.1016/j.clml.2019.12.027.
- Shallis RM, Gleeson S, Azar M, Malinis M, Xu ML, Seropian SE, Gowda L, Zeidan AM. Allogeneic stem cell transplantation and combination antiretroviral therapy: cautions, complications, and considerations. Leukemia & Lymphoma 2019, 60: 2584-2587. PMID: 30943051, DOI: 10.1080/10428194.2019.1594221.
- Perreault S, McManus D, Bar N, Foss F, Gowda L, Isufi I, Seropian S, Malinis M, Topal JE. The impact of a multimodal approach to vancomycin discontinuation in hematopoietic stem cell transplant recipients (HSCT) with febrile neutropenia (FN). Transplant Infectious Disease : An Official Journal Of The Transplantation Society 2019, 21: e13059. PMID: 30737868, DOI: 10.1111/tid.13059.
- Kim TK, DeVeaux M, Stahl M, Perreault S, Isufi I, Cooper D, Foss F, Shlomchik W, Zelterman D, Zeidan AM, Seropian S. Long-term follow-up of a single institution pilot study of sirolimus, tacrolimus, and short course methotrexate for graft versus host disease prophylaxis in mismatched unrelated donor allogeneic stem cell transplantation. Annals Of Hematology 2019, 98: 237-240. PMID: 30027436, DOI: 10.1007/s00277-018-3427-1.
- Hoppe RT, Advani RH, Ai WZ, Ambinder RF, Aoun P, Armand P, Bello CM, Benitez CM, Bierman PJ, Chen R, Dabaja B, Dean R, Forero A, Gordon LI, Hernandez-Ilizaliturri FJ, Hochberg EP, Huang J, Johnston PB, Kaminski MS, Kenkre VP, Khan N, Maddocks K, Maloney DG, Metzger M, Moore JO, Morgan D, Moskowitz CH, Mulroney C, Rabinovitch R, Seropian S, Tao R, Winter JN, Yahalom J, Burns JL, Ogba N. NCCN Guidelines Insights: Hodgkin Lymphoma, Version 1.2018. Journal Of The National Comprehensive Cancer Network : JNCCN 2018, 16: 245-254. PMID: 29523663, DOI: 10.6004/jnccn.2018.0013.
- Cyrenne BM, Gibson JF, Subtil A, Girardi M, Isufi I, Seropian S, Foss F. Transplantation in the Treatment of Primary Cutaneous Aggressive Epidermotropic Cytotoxic CD8-Positive T-Cell Lymphoma. Clinical Lymphoma, Myeloma & Leukemia 2018, 18: e85-e93. PMID: 29223388, DOI: 10.1016/j.clml.2017.11.004.
- Anderson A, McManus D, Perreault S, Lo YC, Seropian S, Topal JE. Combination liposomal amphotericin B, posaconazole and oral amphotericin B for treatment of gastrointestinal Mucorales in an immunocompromised patient. Medical Mycology Case Reports 2017, 17: 11-13. PMID: 28580237, PMCID: PMC5447657, DOI: 10.1016/j.mmcr.2017.05.004.
- Hoppe RT, Advani RH, Ai WZ, Ambinder RF, Aoun P, Bello CM, Benitez CM, Bernat K, Bierman PJ, Blum KA, Chen R, Dabaja B, Forero A, Gordon LI, Hernandez-Ilizaliturri FJ, Hochberg EP, Huang J, Johnston PB, Kaminski MS, Kenkre VP, Khan N, Maloney DG, Mauch PM, Metzger M, Moore JO, Morgan D, Moskowitz CH, Mulroney C, Poppe M, Rabinovitch R, Seropian S, Smith M, Winter JN, Yahalom J, Burns J, Ogba N, Sundar H. Hodgkin Lymphoma Version 1.2017, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network : JNCCN 2017, 15: 608-638. PMID: 28476741, DOI: 10.6004/jnccn.2017.0064.
- Branagan AR, Duffy E, Albrecht RA, Cooper DL, Seropian S, Parker TL, Gan G, Li F, Zelterman D, Boddupalli CS, Zhang L, Verma R, Ferencz TM, Dhodapkar MV. Clinical and Serologic Responses After a Two-dose Series of High-dose Influenza Vaccine in Plasma Cell Disorders: A Prospective, Single-arm Trial. Clinical Lymphoma, Myeloma & Leukemia 2017, 17: 296-304.e2. PMID: 28343904, PMCID: PMC5413398, DOI: 10.1016/j.clml.2017.02.025.
- Perreault S, Baker J, Medoff E, Pratt K, Foss F, Isufi I, Seropian S, Cooper DL. Infusion reactions are common after high-dose carmustine in BEAM chemotherapy and are not reduced by lengthening the time of administration. Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer 2017, 25: 205-208. PMID: 27614867, DOI: 10.1007/s00520-016-3399-4.
- Hur DJ, Dicks DL, Huber S, Mojibian HR, Meadows JL, Seropian SE, Baldassarre LA. Serial Native T1 Mapping to Monitor Cardiac Response to Treatment in Light-Chain Amyloidosis. Circulation. Cardiovascular Imaging 2016, 9 PMID: 27682238, DOI: 10.1161/CIRCIMAGING.116.004770.
- Cooper DL, Medoff E, Patel N, Baker J, Pratt K, Foss F, Seropian SE, Perreault S, Wu Y. Autologous Stem Cell Mobilization in the Age of Plerixafor. Clinical Lymphoma, Myeloma & Leukemia 2016, 16: 411-6. PMID: 27245311, DOI: 10.1016/j.clml.2016.04.007.
- Xu ML, Acevedo-Gadea C, Seropian S, Katz SG. Expression of CD30 as a biomarker to predict response to brentuximab vedotin. Histopathology 2016, 69: 155-8. PMID: 26648051, PMCID: PMC7064871, DOI: 10.1111/his.12914.
- Nadeau M, Perreault S, Seropian S, Foss F, Isufi I, Cooper DL. The use of basiliximab-infliximab combination for the treatment of severe gastrointestinal acute GvHD. Bone Marrow Transplantation 2016, 51: 273-6. PMID: 26479982, DOI: 10.1038/bmt.2015.247.
- Bleakley M, Heimfeld S, Loeb KR, Jones LA, Chaney C, Seropian S, Gooley TA, Sommermeyer F, Riddell SR, Shlomchik WD. Outcomes of acute leukemia patients transplanted with naive T cell-depleted stem cell grafts. The Journal Of Clinical Investigation 2015, 125: 2677-89. PMID: 26053664, PMCID: PMC4563691, DOI: 10.1172/JCI81229.
- Sehgal K, Das R, Zhang L, Verma R, Deng Y, Kocoglu M, Vasquez J, Koduru S, Ren Y, Wang M, Couto S, Breider M, Hansel D, Seropian S, Cooper D, Thakurta A, Yao X, Dhodapkar KM, Dhodapkar MV. Clinical and pharmacodynamic analysis of pomalidomide dosing strategies in myeloma: impact of immune activation and cereblon targets. Blood 2015, 125: 4042-51. PMID: 25869284, PMCID: PMC4481593, DOI: 10.1182/blood-2014-11-611426.
- Hoppe RT, Advani RH, Ai WZ, Ambinder RF, Aoun P, Bello CM, Benitez CM, Bierman PJ, Blum KA, Chen R, Dabaja B, Forero A, Gordon LI, Hernandez-Ilizaliturri FJ, Hochberg EP, Huang J, Johnston PB, Khan N, Maloney DG, Mauch PM, Metzger M, Moore JO, Morgan D, Moskowitz CH, Mulroney C, Poppe M, Rabinovitch R, Seropian S, Tsien C, Winter JN, Yahalom J, Burns JL, Sundar H. Hodgkin lymphoma, version 2.2015. Journal Of The National Comprehensive Cancer Network : JNCCN 2015, 13: 554-86. PMID: 25964641, PMCID: PMC4898052, DOI: 10.6004/jnccn.2015.0075.
- Cecchini M, Sznol M, Seropian S. Immune therapy of metastatic melanoma developing after allogeneic bone marrow transplant. Journal For Immunotherapy Of Cancer 2015, 3: 10. PMID: 25806109, PMCID: PMC4372324, DOI: 10.1186/s40425-015-0054-4.
- Gibson JF, Foss F, Cooper D, Seropian S, Irizarry D, Barbarotta L, Lansigan F. Pilot study of sorafenib in relapsed or refractory peripheral and cutaneous T-cell lymphoma. British Journal Of Haematology 2014, 167: 141-4. PMID: 24888971, DOI: 10.1111/bjh.12944.
- Crooks M, Seropian S, Bai M, McCorkle R. Monitoring patient distress and related problems before and after hematopoietic stem cell transplantation. Palliative & Supportive Care 2014, 12: 53-61. PMID: 24169207, DOI: 10.1017/S1478951513000552.
- Disorders of LymphocytesLacy J, Seropian, S, Disorders of Lymphocytes, Andreoli: in Cecil Essentials of Medicine, 9th ed. 2014
- Parker TL, Cooper DL, Seropian SE, Bolognia JL. Toxic erythema of chemotherapy following i.v. BU plus fludarabine for allogeneic PBSC transplant. Bone Marrow Transplantation 2013, 48: 646-50. PMID: 23165491, DOI: 10.1038/bmt.2012.218.
- Total-Body and HemiBody IrradiationRoberts K, Chen, Z, Seropian S. Total-Body and HemiBody Irradiation, Perez and Brady’s Principles and Practice of Radiation Oncology, Halperin E, Perez C, and Brady L eds. Sixth edition. 2013
- LymphomaIsufi I, Seropian S, Lymphoma, Oncology in Primary Care. Rose, MG, Devita VT, Lawrence TS, Rosenberg SA, 1st edition, 2013
- Plasma Cell DisordersSeropian S, Isufi I, Plasma Cell Disorders, Oncology in Primary Care. Rose, MG, Devita VT, Lawrence TS, Rosenberg SA, 1st edition, 2013
- LeukemiaRoberts K, Seropian S, Marks, P, Leukemia, Perez and Brady’s In Principles and Practice of Radiation Oncology, Halperin E, Perez C, and Brady L eds. Sixth edition. 2013
- Cooper DL, Proytcheva M, Medoff E, Seropian SE, Snyder EL, Krause DS, Wu Y. Successful collection and engraftment of autologous peripheral blood progenitor cells in poorly mobilized patients receiving high-dose granulocyte colony-stimulating factor. Journal Of Clinical Apheresis 2012, 27: 235-41. PMID: 22566214, DOI: 10.1002/jca.21232.
- Omer B, Kadan-Lottick NS, Roberts KB, Wang R, Demsky C, Kupfer GM, Cooper D, Seropian S, Ma X. Patterns of subsequent malignancies after Hodgkin lymphoma in children and adults. British Journal Of Haematology 2012, 158: 615-25. PMID: 22775513, DOI: 10.1111/j.1365-2141.2012.09211.x.
- Aslanian H, Chander B, Robert M, Cooper D, Proctor D, Seropian S, Jain D. Prospective evaluation of acute graft-versus-host disease. Digestive Diseases And Sciences 2012, 57: 720-5. PMID: 22011927, DOI: 10.1007/s10620-011-1938-x.
- King BA, Seropian S, Fox LP. Disseminated fusarium infection with muscle involvement. Journal Of The American Academy Of Dermatology 2011, 65: 235-7. PMID: 21679835, DOI: 10.1016/j.jaad.2009.12.034.
- Cooper DL, Pratt K, Baker J, Medoff E, Conkling-Walsh A, Foss F, Snyder E, Yen W, Seropian SE. Late afternoon dosing of plerixafor for stem cell mobilization: a practical solution. Clinical Lymphoma, Myeloma & Leukemia 2011, 11: 267-72. PMID: 21658654, DOI: 10.1016/j.clml.2011.03.014.
- Strout MP, Seropian S, Berliner N. Alemtuzumab as a bridge to allogeneic SCT in atypical hemophagocytic lymphohistiocytosis. Nature Reviews. Clinical Oncology 2010, 7: 415-20. PMID: 20404855, DOI: 10.1038/nrclinonc.2010.40.
- Chowdhury S, Seropian S, Marks PW. Decitabine combined with fractionated gemtuzumab ozogamicin therapy in patients with relapsed or refractory acute myeloid leukemia. American Journal Of Hematology 2009, 84: 599-600. PMID: 19650144, DOI: 10.1002/ajh.21478.
- Kassar M, Medoff E, Seropian S, Cooper DL. Outpatient high-dose melphalan in multiple myeloma patients. Transfusion 2007, 47: 115-9. PMID: 17207239, DOI: 10.1111/j.1537-2995.2007.01073.x.
- Schaffer JV, McNiff JM, Seropian S, Cooper DL, Bolognia JL. Lichen sclerosus and eosinophilic fasciitis as manifestations of chronic graft-versus-host disease: expanding the sclerodermoid spectrum. Journal Of The American Academy Of Dermatology 2005, 53: 591-601. PMID: 16198778, DOI: 10.1016/j.jaad.2005.06.015.
- Baehring J, Cooper D, Seropian S, Bannykh S. Images in neuro-oncology. Large B-cell lymphoma. Journal Of Neuro-oncology 2004, 67: 189. PMID: 15072466, DOI: 10.1023/b:neon.0000021952.37526.49.
- New Approaches to allografting in non-Hodgkin's lymphoma.Seropian S, Cooper DL. New Approaches to allografting in non-Hodgkin's lymphoma. Progress in Oncology, 2004 Jones and Bartlett.
- Lerro KA, Medoff E, Wu Y, Seropian SE, Snyder E, Krause D, Cooper DL. A simplified approach to stem cell mobilization in multiple myeloma patients not previously treated with alkylating agents. Bone Marrow Transplantation 2003, 32: 1113-7. PMID: 14647264, DOI: 10.1038/sj.bmt.1704286.
- Seropian S, Bahceci E, Cooper DL. Allogeneic peripheral blood stem cell transplantation for high-risk non-Hodgkin's lymphoma. Bone Marrow Transplantation 2003, 32: 763-9. PMID: 14520419, DOI: 10.1038/sj.bmt.1704233.
- Strasser SI, Shulman HM, Flowers ME, Reddy R, Margolis DA, Prumbaum M, Seropian SE, McDonald GB. Chronic graft-versus-host disease of the liver: presentation as an acute hepatitis. Hepatology (Baltimore, Md.) 2000, 32: 1265-71. PMID: 11093733, DOI: 10.1053/jhep.2000.20067.
- Debelak J, Shlomchik MJ, Snyder EL, Cooper D, Seropian S, McGuirk J, Smith B, Krause DS. Isolation and flow cytometric analysis of T-cell-depleted CD34+ PBPCs. Transfusion 2000, 40: 1475-81. PMID: 11134567, DOI: 10.1046/j.1537-2995.2000.40121475.x.
- Marshall NA, Howe JG, Formica R, Krause D, Wagner JE, Berliner N, Crouch J, Pilip I, Cooper D, Blazar BR, Seropian S, Pamer EG. Rapid reconstitution of Epstein-Barr virus-specific T lymphocytes following allogeneic stem cell transplantation. Blood 2000, 96: 2814-21. PMID: 11023516.
- Argiris A, Seropian S, Cooper DL. High-dose BEAM chemotherapy with autologous peripheral blood progenitor-cell transplantation for unselected patients with primary refractory or relapsed Hodgkin's disease. Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / ESMO 2000, 11: 665-72. PMID: 10942053, DOI: 10.1023/a:1008396525292.
- Autologous Stem Cell TransplantationCooper DL, Seropian S, Autologous Stem Cell Transplantation, in Principles and Practice of Oncology. Devita VT, Hellman S, Rosenberg S eds. 6th edition, 2000.
- Hodgkin's DiseaseSeropian S, Cooper DL. Hodgkin's Diseases in Annual of Lymphoid Malignancies. Cavelli F, Longo D eds. 2000
- McGuirk JP, Seropian S, Howe G, Smith B, Stoddart L, Cooper DL. Use of rituximab and irradiated donor-derived lymphocytes to control Epstein-Barr virus-associated lymphoproliferation in patients undergoing related haplo-identical stem cell transplantation. Bone Marrow Transplantation 1999, 24: 1253-8. PMID: 10642818, DOI: 10.1038/sj.bmt.1702052.
- Seropian S, Nadkarni R, Jillella AP, Salloum E, Burtness B, Hu GL, Zelterman D, Cooper DL. Neutropenic infections in 100 patients with non-Hodgkin's lymphoma or Hodgkin's disease treated with high-dose BEAM chemotherapy and peripheral blood progenitor cell transplant: out-patient treatment is a viable option. Bone Marrow Transplantation 1999, 23: 599-605. PMID: 10217191, DOI: 10.1038/sj.bmt.1701610.
- Seropian S, Ferguson D, Salloum E, Cooper D, Landry ML. Lack of reactivity to CMV pp65 antigenemia testing in a patient with CMV disease following allogeneic bone marrow transplant. Bone Marrow Transplantation 1998, 22: 507-9. PMID: 9733277, DOI: 10.1038/sj.bmt.1701354.
- McGuirk JP, Seropian S, Cooper D. HLA-mismatched family donor transplants: a novel strategy as curative therapy for patients with hematologic disorders. The Cancer Journal From Scientific American 1998, 4: 278-86. PMID: 9815289.
- Salloum E, Jillella AP, Nadkarni R, Seropian S, Hu GL, D'Andrea E, Zelterman D, Cooper DL. Assessment of pulmonary and cardiac function after high dose chemotherapy with BEAM and peripheral blood progenitor cell transplantation. Cancer 1998, 82: 1506-12. PMID: 9554528, DOI: 10.1002/(sici)1097-0142(19980415)82:8<1506::aid-cncr12>3.0.co;2-8.
- Yale Medical OncologySmilow Cancer Hospital at Yale New Haven35 Park Street, Ste 7th Floor Multispecialty Care CenterNew Haven, CT 06511
- Yale Medical OncologySmilow Cancer Hospital at Yale New Haven35 Park Street, Ste 7th Floor Multispecialty Care CenterNew Haven, CT 06511