- Yale Cardiac ElectrophysiologyYale Physicians Building800 Howard Avenue, Fl 2New Haven, CT 06519
- Yale CardiologyYale New Haven Hospital20 York StreetNew Haven, CT 06510
- Yale Heart & Vascular Center500 West Putnam AvenueGreenwich, CT 06830
Joseph Akar, MD, PhD
Biography
Joseph Akar, MD, PhD, is director of Yale Medicine’s Electrophysiology and Cardiac Arrhythmia Program. As an electrophysiologist, he treats the “electrical wiring” of the heart, which he describes as being not unlike the wiring in a house. The system must work properly, but the electricity in one of the chambers could get disrupted, he says. Heartbeat sequences that are too fast or slow—or otherwise irregular—can lead to serious problems, including stroke and sudden cardiac death. “It’s very important for the heart to have a uniform and consistent rhythm,” he says.
Dr. Akar treats a variety of issues that can develop in people of all ages, including those with otherwise healthy hearts. He uses techniques such as catheter ablation, a minimally invasive procedure that deliberately cauterizes the electrical short circuits in order to even out erratic rhythms, or arrhythmias. This technique has emerged as a treatment for complex problems such as refractory atrial fibrillation, which is the most common arrhythmia in humans, or ventricular tachycardia which is a major cause of sudden cardiac death. “The advent of ablation procedures for atrial fibrillation and ventricular tachycardia has really revolutionized the field,” Dr. Akar says.
He also has expertise in performing these ablations without fluoroscopy, an X-ray technique that can involve high radiation doses.
Patients who have heart rhythm problems should not hesitate to seek treatment, Dr. Akar says. “We’ve done a lot of work at Yale in refining our technology and techniques for the management of complex arrhythmias,” he says. “It’s been nothing but revolutionary as far as our ability to restore normal rhythms in cases that, in the past, we would never have dreamed that we would be able to.”
Titles
- Professor of Medicine (Cardiovascular Medicine)
- Director, Cardiac Electrophysiology Program, Internal Medicine
- Director, Complex Ablation Program
Education & Training
- FellowUniversity of Virginia (2004)
- PhDUniversity of Virginia (2004)
- FellowUniversity of Virginia (2002)
- ResidentYale-New Haven Hospital (1998)
- MDUniversity of Pittsburgh (1995)
Languages Spoken
- العربية (Arabic)
- English
- Français (French)
Additional Information
- AB of Internal Medicine, Clinical Cardiac Electrophysiology (2005, recertified: 2021)
- AB of Internal Medicine, Cardiovascular Disease (2003, recertified: 2013)
- Reiss M, Mulimani M, Luther S, Akar J, Rappel W, Akar F, Hummel J. PO-05-130 DEMONSTRATING THE IMPACT OF LESION ORIENTATION ON ABLATION EFFICIENCY IN AN ANISOTROPIC MODEL OF PERSISTENT ATRIAL FIBRILLATION. Heart Rhythm 2024, 21: s535. DOI: 10.1016/j.hrthm.2024.03.1365.
- Cacheux M, Velasco J, Wu X, Akar J, Young L, Akar F. MP-470551-008 ATRIAL FIBRILLATION IN MICE WITH AMPK DELETION IS MEDIATED BY TRIGGERED ACTIVITY FROM THE PULMONARY VEIN JUNCTION. Heart Rhythm 2024, 21: s107. DOI: 10.1016/j.hrthm.2024.03.1772.
- Kattel S, Tan Z, Lin Z, Friedman D, Mszar R, Zeitler E, Zei P, Bunch T, Mansour M, Akar J, Curtis J, Freeman J. Abstract 12614: Procedural Volume and Outcomes With Atrial Fibrillation Ablation: A Report From the NCDR AFib Registry. Circulation 2023, 148: a12614-a12614. DOI: 10.1161/circ.148.suppl_1.12614.
- Lamy J, Taoutel R, Chamoun R, Akar J, Niederer S, Mojibian H, Huber S, Baldassarre L, Meadows J, Peters D. Atrial fibrosis by cardiac MRI is a correlate for atrial stiffness in patients with atrial fibrillation. The International Journal Of Cardiovascular Imaging 2023, 40: 107-117. PMID: 37857929, DOI: 10.1007/s10554-023-02968-x.
- Perike S, Gonzalez-Gonzalez F, Abu-Taha I, Damen F, Hanft L, Lizama K, Aboonabi A, Capote A, Aguilar-Sanchez Y, Levin B, Han Z, Sridhar A, Grand J, Martin J, Akar J, Warren C, Solaro R, Ong S, Darbar D, McDonald K, Goergen C, Wolska B, Dobrev D, Wehrens X, McCauley M. PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation. Circulation Research 2023, 133: 758-771. PMID: 37737016, PMCID: PMC10616980, DOI: 10.1161/circresaha.123.322516.
- Gonzalez-Gonzalez F, perike S, Abu-Taha I, Damen F, Lizama K, Aboonabi A, Capote A, Aguilar-Sanchez Y, Levin B, Han Z, Sridhar A, Grand J, Martin J, Akar J, Warren C, Solaro R, Ong S, Darbar D, Goergen C, Wolska B, Dobrev D, Wehrens X, McCauley M. Abstract EC.02: Myosin Light Chain Dephosphorylation By Ppp1r12c Promotes Atria Hypocontractility In Atrial Fibrillation. Circulation Research 2023, 133 DOI: 10.1161/res.133.suppl_1.ec.02.
- Darden D, Aldaas O, Du C, Munir M, Feld G, Pothineni N, Gopinathannair R, Lakkireddy D, Curtis J, Freeman J, Akar J, Hsu J. In-hospital complications associated with pulmonary vein isolation with adjunctive lesions: the NCDR AFib Ablation Registry. EP Europace 2023, 25: euad124. PMID: 37184436, PMCID: PMC10228609, DOI: 10.1093/europace/euad124.
- Kawkabani N, Farah R, Boustros O, Khoury A, Ghanem M, Khalil B, Akar J. PO-02-202 CORONARY SINUS PRESSURE FOLLOWING RETROGRADE CARDIOPLEGIA PREDICTS POSTOPERATIVE ATRIAL FIBRILLATION. Heart Rhythm 2023, 20: s311-s312. DOI: 10.1016/j.hrthm.2023.03.1585.
- Chui P, Lan Z, Freeman J, Enriquez A, Khera R, Akar J, Masoudi F, Ong E, Curtis J. Variation in hospital use of cardiac resynchronization therapy-defibrillator among eligible patients and association with clinical outcomes. Heart Rhythm 2023, 20: 1000-1008. PMID: 36963741, DOI: 10.1016/j.hrthm.2023.03.022.
- Hsu J, Darden D, Du C, Marine J, Nichols S, Marcus G, Natale A, Noseworthy P, Selzman K, Varosy P, Masoudi F, Freeman J, Curtis J, Akar J, Kowey P. Initial Findings From the National Cardiovascular Data Registry of Atrial Fibrillation Ablation Procedures. Journal Of The American College Of Cardiology 2023, 81: 867-878. PMID: 36858707, DOI: 10.1016/j.jacc.2022.11.060.
- Ginder C, Li J, Halperin J, Akar J, Martin D, Chattopadhyay I, Upadhyay G. Predicting Malignant Ventricular Arrhythmias Using Real-Time Remote Monitoring. Journal Of The American College Of Cardiology 2023, 81: 949-961. PMID: 36889873, DOI: 10.1016/j.jacc.2022.12.024.
- Darden D, Aldaas O, Du C, Feld G, Pothineni K, Gopinathannair R, Lakkireddy D, Curtis J, Freeman J, Akar J, Hsu J. Abstract 15360: Characteristics and In-Hospital Outcomes of Patients Undergoing Pulmonary Vein Isolation With and Without Adjunctive Lesions: Insights From the Ncdr Afib Ablation Registry. Circulation 2022, 146: a15360-a15360. DOI: 10.1161/circ.146.suppl_1.15360.
- Gonzalez F, perike S, Damen F, Capote A, Alsina K, Levin B, Sridhar A, Grand J, Martin J, Akar J, Warren C, Solaro R, Darbar D, Goergen C, Wolska B, Wehrens X, McCauley M. Abstract 13258: Myosin Light Chain Dephosphorylation by Ppp1r12c Promotes Atrial Hypocontractility in Atrial Fibrillation. Circulation 2022, 146: a13258-a13258. DOI: 10.1161/circ.146.suppl_1.13258.
- Mszar R, Friedman D, Ong E, Du C, Wang Y, Zeitler E, Cunningham S, Akar J, Curtis J, Freeman J. Sex-based differences in atrial fibrillation ablation adverse events. Heart 2022, 109: 595-605. PMID: 36104219, DOI: 10.1136/heartjnl-2022-321192.
- Cacheux M, Ma Y, Wu X, Akar J, Young L, Akar F. Abstract P1098: Atrial Deletion Of AMPK Promotes Atrial Oxidative Stress And The Formation Of Delayed Afterdepolarizations Within The Inter-atrial Pulmonary Vein Junction. Circulation Research 2022, 131: ap1098-ap1098. DOI: 10.1161/res.131.suppl_1.p1098.
- Ziki M, Hummel J, Lampert R, Akar J. PO-657-07 SPONTANEOUS RESTORATION OF SINUS RHYTHM AFTER INTER ATRIAL SHUNT PLACEMENT IN A PATIENT WITH LONGSTANDING PERSISTENT ATRIAL FIBRILLATION. Heart Rhythm 2022, 19: s273-s274. DOI: 10.1016/j.hrthm.2022.03.295.
- Gonzalez-Gonzalez F, Perike S, Damen F, Capote A, Alsina K, Levin B, Sridhar A, Grand J, Martin J, Akar J, Warren C, Solaro J, Darbar D, Goergen C, Wolska B, Wehrens X, McCauley M. Abstract P458: Myosin Light Chain Dephosphorylation By Ppp1r12c Promotes Atrial Hypocontractility In Atrial Fibrillation. Circulation Research 2021, 129: ap458-ap458. DOI: 10.1161/res.129.suppl_1.p458.
- Strauss B, Obus E, Katz M, Fargnoli A, Cacheux M, Akar J, Hummel J, Sassi Y, Akar F. B-PO02-027 RIGHT PREDOMINANT ELECTRICAL REMODELING IN A PURE MODEL OF PULMONARY HYPERTENSION PROMOTES REENTRANT ARRHYTHMIAS. Heart Rhythm 2021, 18: s106. DOI: 10.1016/j.hrthm.2021.06.284.
- Ziki M, Bhat N, Neogi A, Abboud J, Chouairi S, Ugwu N, Driscoll T, Liu Y, Smith E, Schwartz M, Akar J, Mani A. B-AB13-03 NOVEL ROLE OF PDE4DIP IN FAMILIAL ATRIAL FIBRILLATION WITH SLOW VENTRICULAR RESPONSE. Heart Rhythm 2021, 18: s26. DOI: 10.1016/j.hrthm.2021.06.078.
- Gonzalez-Gonzalez F, Srikanth P, Capote A, Katherina M A, Levin B, Sridhar A, Jacob G, Martin J, Akar J, Warren C, Solaro J, Darbar D, Goergen C, Wolska B, Wehrens X, McCauley M. Abstract P780: Myosin Light Chain Dephosphorylation by Ppp1r12c Promotes Atrial Hypocontractility in Atrial Fibrillation. Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.p780.
- Friedman D, Parzynski C, Heist E, Russo A, Ranasinghe I, Zeitler E, Minges K, Akar J, Freeman J, Curtis J, Al-khatib S. Abstract 16496: Longitudinal Outcomes After Implantation of a Subcutaneous or Transvenous Implantable Cardioverter Defibrillator in Older Patients: A Report From the National Cardiovascular Data Registry. Circulation 2020, 142 DOI: 10.1161/circ.142.suppl_3.16496.
- Hsu J, Akar J, Marine J, Nichols S, Marcus G, Natale A, Noseworthy P, selzman K, Varosy P, Masoudi F, Du C, Freeman J, Curtis J, Kowey P. Abstract 12785: The American College of Cardiology's NCDR Afib Ablation Registry: A Summary of Initial Data Including Patient Characteristics, Procedural Characteristics, and Adverse Events. Circulation 2020, 142 DOI: 10.1161/circ.142.suppl_3.12785.
- Hummel JP, Maraj I, Taoutel R, Chamoun R, Workman VK, Tran L, Abboud JM, Afif C, Chouairi S, Delvecchio A, Howes CJ, Enriquez AD, Akar JG. Temporal Trends in Arrhythmogenicity Related to Treatment of COVID-19 Infection. Circulation Arrhythmia And Electrophysiology 2020, 13: e008841-e008841. PMID: 32931318, PMCID: PMC7566294, DOI: 10.1161/circep.120.008841.
- Hummel JP, Akar JG. Reply to: “QT prolongation with hydroxychloroquine and azithromycin for the treatment of COVID‐19: The need for pharmacogenetic insights”. Journal Of Cardiovascular Electrophysiology 2020, 31: 2795-2795. PMID: 32864768, DOI: 10.1111/jce.14721.
- Workman V, Freeman JV, Obasare ER, Jain S, Ganeshan R, Burr A, Blitzer M, Akar J, Lampert R. Risk of COVID-19 infection after cardiac electrophysiology procedures. Heart Rhythm O2 2020, 1: 239-242. PMID: 32904452, PMCID: PMC7455246, DOI: 10.1016/j.hroo.2020.08.006.
- Maraj I, Hummel JP, Taoutel R, Chamoun R, Workman V, Li C, Tran L, DelVecchio A, Howes C, Akar JG. Incidence and determinants of QT interval prolongation in COVID‐19 patients treated with hydroxychloroquine and azithromycin. Journal Of Cardiovascular Electrophysiology 2020, 31: 1904-1907. PMID: 32485061, PMCID: PMC7300464, DOI: 10.1111/jce.14594.
- Jain S, Workman V, Ganeshan R, Obasare ER, Burr A, DeBiasi RM, Freeman JV, Akar J, Lampert R, Rosenfeld LE. Enhanced electrocardiographic monitoring of patients with Coronavirus Disease 2019. Heart Rhythm 2020, 17: 1417-1422. PMID: 32387247, PMCID: PMC7200355, DOI: 10.1016/j.hrthm.2020.04.047.
- Ortiz-Leon XA, Posada-Martinez EL, Trejo-Paredes MC, Ivey-Miranda JB, Pereira J, Crandall I, DaSilva P, Bouman E, Brooks A, Gerardi C, Ugonabo I, Chen W, Houle H, Akar JG, Lin BA, McNamara RL, Lombo-Lievano B, Arias-Godinez JA, Sugeng L. Understanding tricuspid valve remodelling in atrial fibrillation using three-dimensional echocardiography. European Heart Journal - Cardiovascular Imaging 2020, 21: 747-755. PMID: 32372089, DOI: 10.1093/ehjci/jeaa058.
- Yu R, Liu N, Lu J, Zhao X, Hu Y, Zhang J, Xu F, Tang R, Bai R, Akar JG, Dong J, Ma C. 3-Dimensional Transseptal Puncture Based on Electrographic Characteristics of Fossa Ovalis A Fluoroscopy-Free and Echocardiography-Free Method. JACC Cardiovascular Interventions 2020, 13: 1223-1232. PMID: 32438994, DOI: 10.1016/j.jcin.2020.03.015.
- Friedman D, Pokorney S, Ghanem A, Marcello S, Kalsekar I, Yadalam S, Akar J, Freeman J, Goldstein L, Khanna R, Piccini J. TT2 CARDIAC PERFORATION AMONG PATIENTS WITH ATRIAL FIBRILLATION UNDERGOING ABLATION: WHAT ARE THE UNDERLYING PREDICTORS? Value In Health 2020, 23: s385-s386. DOI: 10.1016/j.jval.2020.04.1502.
- Dhruva SS, Ross JS, Akar JG, Caldwell B, Childers K, Chow W, Ciaccio L, Coplan P, Dong J, Dykhoff HJ, Johnston S, Kellogg T, Long C, Noseworthy PA, Roberts K, Saha A, Yoo A, Shah ND. Aggregating multiple real-world data sources using a patient-centered health-data-sharing platform. Npj Digital Medicine 2020, 3: 60. PMID: 32352038, PMCID: PMC7170944, DOI: 10.1038/s41746-020-0265-z.
- Freeman JV, Varosy P, Price MJ, Slotwiner D, Kusumoto FM, Rammohan C, Kavinsky CJ, Turi ZG, Akar J, Koutras C, Curtis JP, Masoudi FA. The NCDR Left Atrial Appendage Occlusion Registry. Journal Of The American College Of Cardiology 2020, 75: 1503-1518. PMID: 32238316, PMCID: PMC7205034, DOI: 10.1016/j.jacc.2019.12.040.
- Friedman DJ, Pokorney SD, Ghanem A, Marcello S, Kalsekar I, Yadalam S, Akar JG, Freeman JV, Goldstein L, Khanna R, Piccini JP. Predictors of Cardiac Perforation With Catheter Ablation of Atrial Fibrillation. JACC Clinical Electrophysiology 2020, 6: 636-645. PMID: 32553212, DOI: 10.1016/j.jacep.2020.01.011.
- Ortiz-Leon X, Posada E, Trejo M, Miranda J, Pereira J, Crandall I, DaSilva P, Bouman E, Brooks A, Gerardi C, Houle H, Akar J, Lin B, McNamara R, Lombo B, Arias-Godínez J, Sugeng L. TRICUSPID AND MITRAL REMODELING IN ATRIAL FIBRILLATION: A THREE-DIMENSIONAL ECHOCARDIOGRAPHIC STUDY. Journal Of The American College Of Cardiology 2020, 75: 1706. DOI: 10.1016/s0735-1097(20)32333-0.
- Ortiz-Leon X, Posada E, Chen W, Bregasi A, Crandall I, Pereira J, Miranda J, Akar J, Lin B, McNamara R, Freeman J, Curtis J, Arias-Godínez J, Sugeng L. CHANGES OF LEFT ATRIAL APPENDAGE ORIFICE FOLLOWING PERCUTANEOUS LEFT ATRIAL APPENDAGE CLOSURE USING THREE-DIMENSIONAL ECHOCARDIOGRAPHY. Journal Of The American College Of Cardiology 2020, 75: 1708. DOI: 10.1016/s0735-1097(20)32335-4.
- Akar J, Charif M, Dib G, Abboud J, Chouairi S. IVABRADINE USE MAY BE ASSOCIATED WITH INCREASED BURDEN OF IDIOPATHIC PREMATURE CONTRACTIONS. Journal Of The American College Of Cardiology 2020, 75: 2640. DOI: 10.1016/s0735-1097(20)33267-8.
- Baher A, Buck B, Fanarjian M, Mounsey J, Gehi A, Chung E, Akar FG, Webber CL, Akar JG, Hummel JP. Recurrence quantification analysis of complex‐fractionated electrograms differentiates active and passive sites during atrial fibrillation. Journal Of Cardiovascular Electrophysiology 2019, 30: 2229-2238. PMID: 31507008, DOI: 10.1111/jce.14161.
- Hummel JP, Leipold RJ, Amorosi SL, Bao H, Deger KA, Jones PW, Kansal AR, Ott LS, Stern S, Stein K, Curtis JP, Akar JG. Outcomes and costs of remote patient monitoring among patients with implanted cardiac defibrillators: An economic model based on the PREDICT RM database. Journal Of Cardiovascular Electrophysiology 2019, 30: 1066-1077. PMID: 30938894, PMCID: PMC6850124, DOI: 10.1111/jce.13934.
- Hummel JP, Kadado AJ, Baker M, Gehi AK, Mounsey JP, Sadaf MI, Enriquez AD, Freeman JV, Akar JG. Atrial Fibrillation Thermographic and Endoscopic Monitoring of Patients: Safety Algorithm for the Esophagus. Circulation Arrhythmia And Electrophysiology 2018, 11: e006814. PMID: 30562101, DOI: 10.1161/circep.118.006814.
- Kadado AJ, Akar JG, Hummel JP. Luminal esophageal temperature monitoring to reduce esophageal thermal injury during catheter ablation for atrial fibrillation: A review. Trends In Cardiovascular Medicine 2018, 29: 264-271. PMID: 30282588, DOI: 10.1016/j.tcm.2018.09.010.
- Hummel JP, Akar JG, Baher A, Webber CL. New skip parameter to facilitate recurrence quantification of signals comprised of multiple components. Chaos An Interdisciplinary Journal Of Nonlinear Science 2018, 28: 085718. PMID: 30180597, DOI: 10.1063/1.5024845.
- Friedman DJ, Parzynski CS, Heist EK, Russo AM, Akar JG, Freeman JV, Curtis JP, Al-Khatib SM. Ventricular Fibrillation Conversion Testing After Implantation of a Subcutaneous Implantable Cardioverter Defibrillator. Circulation 2018, 137: 2463-2477. PMID: 29463509, PMCID: PMC5988932, DOI: 10.1161/circulationaha.117.032167.
- Kadado AJ, Freeman J, Akar JG. Postoperative Atrial Fibrillation and Maslow’s Hammer. Anesthesia & Analgesia 2018, 126: 19-20. PMID: 29252478, DOI: 10.1213/ane.0000000000002414.
- Karam BS, Chavez-Moreno A, Koh W, Akar JG, Akar FG. Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes. Cardiovascular Diabetology 2017, 16: 120. PMID: 28962617, PMCID: PMC5622555, DOI: 10.1186/s12933-017-0604-9.
- Calkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen PS, Chen SA, Chung MK, Nielsen J, Curtis AB, Davies DW, Day JD, d’Avila A, de Groot N, Di Biase L, Duytschaever M, Edgerton JR, Ellenbogen KA, Ellinor PT, Ernst S, Fenelon G, Gerstenfeld EP, Haines DE, Haissaguerre M, Helm RH, Hylek E, Jackman WM, Jalife J, Kalman JM, Kautzner J, Kottkamp H, Kuck KH, Kumagai K, Lee R, Lewalter T, Lindsay BD, Macle L, Mansour M, Marchlinski FE, Michaud GF, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds MR, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao HM, Verma A, Wilber DJ, Yamane T, Blomström-Lundqvist C, De Paola A, Kistler P, Lip G, Peters N, Pisani C, Raviele A, Saad E, Satomi K, Stiles M, Willems S. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation. EP Europace 2017, 20: e1-e160. PMID: 29016840, PMCID: PMC5834122, DOI: 10.1093/europace/eux274.
- Calkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen PS, Chen SA, Chung MK, Nielsen JC, Curtis AB, Wyn Davies D, Day JD, d’Avila A, de Groot N, Di Biase L, Duytschaever M, Edgerton JR, Ellenbogen KA, Ellinor PT, Ernst S, Fenelon G, Gerstenfeld EP, Haines DE, Haissaguerre M, Helm RH, Hylek E, Jackman WM, Jalife J, Kalman JM, Kautzner J, Kottkamp H, Kuck KH, Kumagai K, Lee R, Lewalter T, Lindsay BD, Macle L, Mansour M, Marchlinski FE, Michaud GF, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds MR, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao HM, Verma A, Wilber DJ, Yamane T. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary. Journal Of Interventional Cardiac Electrophysiology 2017, 50: 1-55. PMID: 28914401, PMCID: PMC5633646, DOI: 10.1007/s10840-017-0277-z.
- Calkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen PS, Chen SA, Chung MK, Nielsen JC, Curtis AB, Davies DW, Day JD, d'Avila A, de Groot NMSN, Di Biase L, Duytschaever M, Edgerton JR, Ellenbogen KA, Ellinor PT, Ernst S, Fenelon G, Gerstenfeld EP, Haines DE, Haissaguerre M, Helm RH, Hylek E, Jackman WM, Jalife J, Kalman JM, Kautzner J, Kottkamp H, Kuck KH, Kumagai K, Lee R, Lewalter T, Lindsay BD, Macle L, Mansour M, Marchlinski FE, Michaud GF, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds MR, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao HM, Verma A, Wilber DJ, Yamane T. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary. EP Europace 2017, 20: 157-208. PMID: 29016841, PMCID: PMC5892164, DOI: 10.1093/europace/eux275.
- Calkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen PS, Chen SA, Chung MK, Nielsen JC, Curtis AB, Davies DW, Day JD, d'Avila A, de Groot NMSN, Di Biase L, Duytschaever M, Edgerton JR, Ellenbogen KA, Ellinor PT, Ernst S, Fenelon G, Gerstenfeld EP, Haines DE, Haissaguerre M, Helm RH, Hylek E, Jackman WM, Jalife J, Kalman JM, Kautzner J, Kottkamp H, Kuck KH, Kumagai K, Lee R, Lewalter T, Lindsay BD, Macle L, Mansour M, Marchlinski FE, Michaud GF, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds MR, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao HM, Verma A, Wilber DJ, Yamane T. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary. Journal Of Arrhythmia 2017, 33: 369-409. PMID: 29021841, PMCID: PMC5634725, DOI: 10.1016/j.joa.2017.08.001.
- Calkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen PS, Chen SA, Chung MK, Nielsen JC, Curtis AB, Davies DW, Day JD, d'Avila A, de Groot NMSN, Di Biase L, Duytschaever M, Edgerton JR, Ellenbogen KA, Ellinor PT, Ernst S, Fenelon G, Gerstenfeld EP, Haines DE, Haissaguerre M, Helm RH, Hylek E, Jackman WM, Jalife J, Kalman JM, Kautzner J, Kottkamp H, Kuck KH, Kumagai K, Lee R, Lewalter T, Lindsay BD, Macle L, Mansour M, Marchlinski FE, Michaud GF, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds MR, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao HM, Verma A, Wilber DJ, Yamane T. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary. Heart Rhythm 2017, 14: e445-e494. PMID: 31631881, DOI: 10.1016/j.hrthm.2017.07.009.
- Calkins H, Hindricks G, Cappato R, Kim Y, Saad E, Aguinaga L, Akar J, Badhwar V, Brugada J, Camm J, Chen P, Chen S, Chung M, Nielsen J, Curtis A, Davies D, Day J, d’Avila A, de Groot N, Di Biase L, Duytschaever M, Edgerton J, Ellenbogen K, Ellinor P, Ernst S, Fenelon G, Gerstenfeld E, Haines D, Haissaguerre M, Helm R, Hylek E, Jackman W, Jalife J, Kalman J, Kautzner J, Kottkamp H, Kuck K, Kumagai K, Lee R, Lewalter T, Lindsay B, Macle L, Mansour M, Marchlinski F, Michaud G, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds M, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao H, Verma A, Wilber D, Yamane T. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation. Journal Of Arrhythmia 2017 DOI: 10.1016/j.joa.2017.07.001.
- Hummel JP, Baher A, Buck B, Fanarjian M, Webber CL, Akar JG. A method for quantifying recurrent patterns of local wavefront direction during atrial fibrillation. Computers In Biology And Medicine 2017, 89: 497-504. PMID: 28889077, DOI: 10.1016/j.compbiomed.2017.08.027.
- Ross JS, Bates J, Parzynski CS, Akar JG, Curtis JP, Desai NR, Freeman JV, Gamble GM, Kuntz R, Li SX, Marinac-Dabic D, Masoudi FA, Normand ST, Ranasinghe I, Shaw RE, Krumholz HM. Can machine learning complement traditional medical device surveillance? A case-study of dual-chamber implantable cardioverter–defibrillators. Medical Devices Evidence And Research 2017, 10: 165-188. PMID: 28860874, PMCID: PMC5566316, DOI: 10.2147/mder.s138158.
- Kadado AJ, Akar JG, Hummel JP. Arrhythmias after left ventricular assist device implantation: Incidence and management. Trends In Cardiovascular Medicine 2017, 28: 41-50. PMID: 28734595, DOI: 10.1016/j.tcm.2017.07.002.
- Hummel J, Leipold R, Amorosi, Bao H, Deger K, Jones P, Stivland T, Kansal A, Ott L, Stern S, Stein K, Curtis J, Akar J. P1639Outcomes and costs of remote patient monitoring among patients with implanted cardiac defibrillators: an economic model based on the PREDICt RM database. EP Europace 2017, 19: iii353-iii353. DOI: 10.1093/ehjci/eux158.265.
- Ziki M, Seidelmann SB, Smith E, Atteya G, Jiang Y, Fernandes RG, Marieb MA, Akar JG, Mani A. Deleterious protein‐altering mutations in the SCN10A voltage‐gated sodium channel gene are associated with prolonged QT. Clinical Genetics 2017, 93: 741-751. PMID: 28407228, PMCID: PMC5640462, DOI: 10.1111/cge.13036.
- Calkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen PS, Chen SA, Chung MK, Nielsen JC, Curtis AB, Davies DW, Day JD, d'Avila A, de Groot NMSN, Di Biase L, Duytschaever M, Edgerton JR, Ellenbogen KA, Ellinor PT, Ernst S, Fenelon G, Gerstenfeld EP, Haines DE, Haissaguerre M, Helm RH, Hylek E, Jackman WM, Jalife J, Kalman JM, Kautzner J, Kottkamp H, Kuck KH, Kumagai K, Lee R, Lewalter T, Lindsay BD, Macle L, Mansour M, Marchlinski FE, Michaud GF, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds MR, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao HM, Verma A, Wilber DJ, Yamane T. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation. Heart Rhythm 2017, 14: e275-e444. PMID: 28506916, PMCID: PMC6019327, DOI: 10.1016/j.hrthm.2017.05.012.
- Calkins H, Hindricks G, Cappato R, Kim Y, Saad E, Aguinaga L, Akar J, Badhwar V, Brugada J, Camm J, Chen P, Chen S, Chung M, Nielsen J, Curtis A, Davies D, Day J, d'Avila A, de Groot N, Di Biase L, Duytschaever M, Edgerton J, Ellenbogen K, Ellinor P, Ernst S, Fenelon G, Gerstenfeld E, Haines D, Haissaguerre M, Helm R, Hylek E, Jackman W, Jalife J, Kalman J, Kautzner J, Kottkamp H, Kuck K, Kumagai K, Lee R, Lewalter T, Lindsay B, Macle L, Mansour M, Marchlinski F, Michaud G, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds M, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao H, Verma A, Wilber D, Yamane T. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation. Journal Of Arrhythmia 2017 DOI: 10.1016/j.joa.2017.05.001.
- Al-Chekakie MO, Bao H, Jones PW, Stein KM, Marzec L, Varosy PD, Masoudi FA, Curtis JP, Akar JG. Addition of Blood Pressure and Weight Transmissions to Standard Remote Monitoring of Implantable Defibrillators and its Association with Mortality and Rehospitalization. Circulation Cardiovascular Quality And Outcomes 2017, 10: e003087. PMID: 28506978, DOI: 10.1161/circoutcomes.116.003087.
- Ziki M, Seidelmann S, Smith E, Narayanan A, Atteya G, Jiang Y, Gil-Fernandez R, Marieb M, Akar J, Mani A. DELETERIOUS MUTATIONS IN SCN10A ARE ASSOCIATED WITH LONG QT SYNDROME. Journal Of The American College Of Cardiology 2017, 69: 509. DOI: 10.1016/s0735-1097(17)33898-6.
- Lansky AJ, Messé SR, Brickman AM, Dwyer M, van der Worp H, Lazar RM, Pietras CG, Abrams KJ, McFadden E, Petersen NH, Browndyke J, Prendergast B, Ng VG, Cutlip DE, Kapadia S, Krucoff MW, Linke A, Moy C, Schofer J, van Es GA, Virmani R, Popma J, Parides MK, Kodali S, Bilello M, Zivadinov R, Akar J, Furie KL, Gress D, Voros S, Moses J, Greer D, Forrest JK, Holmes D, Kappetein AP, Mack M, Baumbach A. Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials. European Heart Journal 2017, 39: 1687-1697. PMID: 28171522, PMCID: PMC6251670, DOI: 10.1093/eurheartj/ehx037.
- Freeman JV, Wang Y, Akar J, Desai N, Krumholz H. National Trends in Atrial Fibrillation Hospitalization, Readmission, and Mortality for Medicare Beneficiaries, 1999–2013. Circulation 2017, 135: 1227-1239. PMID: 28148599, DOI: 10.1161/circulationaha.116.022388.
- Lansky AJ, Messé SR, Brickman AM, Dwyer M, van der Worp HB, Lazar RM, Pietras CG, Abrams KJ, McFadden E, Petersen NH, Browndyke J, Prendergast B, Ng VG, Cutlip DE, Kapadia S, Krucoff MW, Linke A, Moy CS, Schofer J, van Es GA, Virmani R, Popma J, Parides MK, Kodali S, Bilello M, Zivadinov R, Akar J, Furie KL, Gress D, Voros S, Moses J, Greer D, Forrest JK, Holmes D, Kappetein AP, Mack M, Baumbach A. Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials An Academic Research Consortium Initiative. Journal Of The American College Of Cardiology 2017, 69: 679-691. PMID: 28183511, DOI: 10.1016/j.jacc.2016.11.045.
- Seidelmann SB, Smith E, Subrahmanyan L, Dykas D, Abou Ziki MD, Azari B, Hannah-Shmouni F, Jiang Y, Akar JG, Marieb M, Jacoby D, Bale AE, Lifton RP, Mani A. Application of Whole Exome Sequencing in the Clinical Diagnosis and Management of Inherited Cardiovascular Diseases in Adults. Circulation Genomic And Precision Medicine 2017, 10: e001573. PMID: 28087566, PMCID: PMC5245580, DOI: 10.1161/circgenetics.116.001573.
- Lip GY, Waldo AL, Ip J, Martin DT, Bersohn MM, Choucair WK, Akar JG, Wathen M, Halperin JL, Investigators I. Determinants of Time in Therapeutic Range in Patients Receiving Oral Anticoagulants (A Substudy of IMPACT). The American Journal Of Cardiology 2016, 118: 1680-1684. PMID: 27665206, DOI: 10.1016/j.amjcard.2016.08.047.
- Curtis JP, Akar JG. A Fresh Perspective on Atrial Fibrillation∗. Journal Of The American College Of Cardiology 2016, 68: 905-907. PMID: 27561763, DOI: 10.1016/j.jacc.2016.06.019.
- Goette A, Kalman JM, Aguinaga L, Akar J, Cabrera JA, Chen SA, Chugh SS, Corradi D, D'Avila A, Dobrev D, Fenelon G, Gonzalez M, Hatem SN, Helm R, Hindricks G, Ho SY, Hoit B, Jalife J, Kim Y, Lip GY, Ma C, Marcus GM, Murray K, Nogami A, Sanders P, Uribe W, Van Wagoner DR, Nattel S, Document Reviewers: Osmar A. Centurion K, Shantsila R. EHRA/HRS/APHRS/SOLAECE expert consensus on Atrial cardiomyopathies: Definition, characterisation, and clinical implication. Journal Of Arrhythmia 2016, 32: 247-278. PMID: 27588148, PMCID: PMC4996910, DOI: 10.1016/j.joa.2016.05.002.
- Goette A, Kalman JM, Aguinaga L, Akar J, Cabrera JA, Chen SA, Chugh SS, Corradi D, D'Avila A, Dobrev D, Fenelon G, Gonzalez M, Hatem SN, Helm R, Hindricks G, Ho SY, Hoit B, Jalife J, Kim YH, Lip GY, Ma CS, Marcus GM, Murray K, Nogami A, Sanders P, Uribe W, Van Wagoner DR, Nattel S, Centurion O, Kuck K, Patton K, Sapp J, Stiles M, Svendsen J, Upadhyay G, Shantsila A. EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication. EP Europace 2016, 18: 1455-1490. PMID: 27402624, PMCID: PMC6392440, DOI: 10.1093/europace/euw161.
- Akar JG, Hummel JP. Editorial commentary: Virtual medicine—A better reality? Trends In Cardiovascular Medicine 2016, 26: 731-732. PMID: 27737760, DOI: 10.1016/j.tcm.2016.06.012.
- Goette A, Kalman JM, Aguinaga L, Akar J, Cabrera JA, Chen SA, Chugh SS, Corradi D, D’Avila A, Dobrev D, Fenelon G, Gonzalez M, Hatem SN, Helm R, Hindricks G, Ho SY, Hoit B, Jalife J, Kim YH, Lip GY, Ma CS, Marcus GM, Murray K, Nogami A, Sanders P, Uribe W, Van Wagoner DR, Nattel S. EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: Definition, characterization, and clinical implication. Heart Rhythm 2016, 14: e3-e40. PMID: 27320515, PMCID: PMC5548137, DOI: 10.1016/j.hrthm.2016.05.028.
- Ranasinghe I, Parzynski CS, Freeman JV, Dreyer RP, Ross JS, Akar JG, Krumholz HM, Curtis JP. Long-Term Risk for Device-Related Complications and Reoperations After Implantable Cardioverter-Defibrillator Implantation: An Observational Cohort Study. Annals Of Internal Medicine 2016, 165: 20-29. PMID: 27135392, DOI: 10.7326/m15-2732.
- Akar J, El-Hachem G, Ayyash B, Kadado A, Nabbout R, Lamaa N, Bao H, Khalil B. BASELINE RED CELL DISTRIBUTION WIDTH INDEPENDENTLY PREDICTS POST-OPERATIVE ATRIAL FIBRILLATION. Journal Of The American College Of Cardiology 2016, 67: 729. DOI: 10.1016/s0735-1097(16)30730-6.
- Kim GE, Ross JL, Xie C, Su KN, Zaha VG, Wu X, Palmeri M, Ashraf M, Akar JG, Russell KS, Akar FG, Young LH. LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation. Cardiovascular Research 2015, 108: 197-208. PMID: 26378152, PMCID: PMC4571838, DOI: 10.1093/cvr/cvv212.
- Akar JG, Bao H, Jones PW, Wang Y, Varosy PD, Masoudi FA, Stein KM, Saxon LA, Normand SL, Curtis JP. Use of Remote Monitoring Is Associated With Lower Risk of Adverse Outcomes Among Patients With Implanted Cardiac Defibrillators. Circulation Arrhythmia And Electrophysiology 2015, 8: 1173-1180. PMID: 26092577, DOI: 10.1161/circep.114.003030.
- Slotwiner D, Varma N, Akar JG, Annas G, Beardsall M, Fogel RI, Galizio NO, Glotzer TV, Leahy RA, Love CJ, McLean RC, Mittal S, Morichelli L, Patton KK, Raitt MH, Ricci RP, Rickard J, Schoenfeld MH, Serwer GA, Shea J, Varosy P, Verma A, Yu CM. HRS Expert Consensus Statement on remote interrogation and monitoring for cardiovascular implantable electronic devices. Heart Rhythm 2015, 12: e69-e100. PMID: 25981148, DOI: 10.1016/j.hrthm.2015.05.008.
- Akar JG, Marieb MA. Atrial Fibrillation and Thrombogenesis Innocent Bystander or Guilty Accomplice?∗. JACC Clinical Electrophysiology 2015, 1: 218-219. PMID: 29759367, DOI: 10.1016/j.jacep.2015.05.003.
- Martin DT, Bersohn MM, Waldo AL, Wathen MS, Choucair WK, Lip GY, Ip J, Holcomb R, Akar JG, Halperin JL. Randomized trial of atrial arrhythmia monitoring to guide anticoagulation in patients with implanted defibrillator and cardiac resynchronization devices. European Heart Journal 2015, 36: 1660-1668. PMID: 25908774, DOI: 10.1093/eurheartj/ehv115.
- Altaf F, Akar J, Lichtman J, Bao H, Jones P, Varosy P, Masoudi F, Stein K, Saxon L, Curtis J. VARIATIONS IN USE OF REMOTE MONITORING OF IMPLANTABLE DEFIBRILLATORS RELATIVE TO THE INTRODUCTION OF BILLING CODES SPECIFIC TO REMOTE MONITORING. Journal Of The American College Of Cardiology 2015, 65: a459. DOI: 10.1016/s0735-1097(15)60459-4.
- Haines DE, Beheiry S, Akar JG, Baker JL, Beinborn D, Beshai JF, Brysiewicz N, Chiu-Man C, Collins KK, Dare M, Fetterly K, Fisher JD, Hongo R, Irefin S, Lopez J, Miller JM, Perry JC, Slotwiner DJ, Tomassoni GF, Weiss E. Heart Rhythm Society Expert Consensus Statement on Electrophysiology Laboratory Standards: Process, Protocols, Equipment, Personnel, and Safety. Heart Rhythm 2014, 11: e9-e51. PMID: 24814989, PMCID: PMC7106221, DOI: 10.1016/j.hrthm.2014.03.042.
- Brysiewicz N, Mitiku T, Haleem K, Bhatt P, Al-Shaaraoui M, Clancy JF, Marieb MA, Sugeng L, Akar JG. 3D Real-Time Intracardiac Echocardiographic Visualization of Atrial Structures Relevant to Atrial Fibrillation Ablation. JACC Cardiovascular Imaging 2014, 7: 97-100. PMID: 24433712, DOI: 10.1016/j.jcmg.2013.09.018.
- Akar JG, Bao H, Jones P, Wang Y, Chaudhry SI, Varosy P, Masoudi FA, Stein K, Saxon LA, Curtis JP. Use of Remote Monitoring of Newly Implanted Cardioverter-Defibrillators. Circulation 2013, 128: 2372-2383. PMID: 24043302, DOI: 10.1161/circulationaha.113.002481.
- Mukherjee R, Akar JG, Wharton JM, Adams DK, McClure CD, Stroud RE, Rice AD, DeSantis SM, Spinale FG, Gold MR. Plasma Profiles of Matrix Metalloproteinases and Tissue Inhibitors of the Metalloproteinases Predict Recurrence of Atrial Fibrillation Following Cardioversion. Journal Of Cardiovascular Translational Research 2013, 6: 528-535. PMID: 23722357, DOI: 10.1007/s12265-013-9471-2.
- RUISI CP, BRYSIEWICZ N, ASNES JD, SUGENG L, MARIEB M, CLANCY J, AKAR JG. Use of Intracardiac Echocardiography during Atrial Fibrillation Ablation. Pacing And Clinical Electrophysiology 2013, 36: 781-788. PMID: 23305194, DOI: 10.1111/pace.12030.
- Al Chekakie MO, Akar JG. Epicardial Fat and Atrial Fibrillation: A Review. Journal Of Atrial Fibrillation 2012, 4: 483. PMID: 28496734, PMCID: PMC5153200, DOI: 10.4022/jafib.483.
- Calkins H, Hindricks G, Cappato R, Kim Y, Saad E, Aguinaga L, Akar J, Badhwar V, Brugada J, Camm J, Chen P, Chen S, Chung M, Nielsen J, Curtis A, Davies D, Day J, d’Avila A, de Groot N, Di Biase L, Duytschaever M, Edgerton J, Ellenbogen K, Ellinor P, Ernst S, Fenelon G, Gerstenfeld E, Haines D, Haissaguerre M, Helm R, Hylek E, Jackman W, Jalife J, Kalman J, Kautzner J, Kottkamp H, Kuck K, Kumagai K, Lee R, Lewalter T, Lindsay B, Macle L, Mansour M, Marchlinski F, Michaud G, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds M, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao H, Verma A, Wilber D, Yamane T. 2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Patient Selection, Procedural Techniques, Patient Management and Follow-up, Definitions, Endpoints, and Research Trial Design. Heart Rhythm 2012, 9: 632-696.e21. PMID: 22386883, PMCID: PMC5846182, DOI: 10.1016/j.hrthm.2011.12.016.
- Lin B, Akar J, Mukherjee R, Purushothaman K, Eckhouse S, Liu C, Papademetris X, Dione D, Spinale F, Sinusas A. Abstract 8449: Evaluation of Atrial Remodeling and Fibrillation Vulnerability Using Molecular Imaging of Matrix Metalloproteinases. Circulation 2011, 124 DOI: 10.1161/circ.124.suppl_21.a8449.
- CLANCY JF, AKAR JG. Caveat Emptor: Implantable Devices in End‐Stage Renal Disease. Journal Of Cardiovascular Electrophysiology 2011, 22: 1105-1106. PMID: 21848637, DOI: 10.1111/j.1540-8167.2011.02094.x.
- WEBBER C, HU Z, AKAR J. UNSTABLE CARDIAC SINGULARITIES MAY LEAD TO ATRIAL FIBRILLATION. International Journal Of Bifurcation And Chaos 2011, 21: 1141-1151. DOI: 10.1142/s0218127411028994.
- Chekakie M, Akar J. Reply. Journal Of The American College Of Cardiology 2011, 57: 1249. DOI: 10.1016/j.jacc.2010.10.032.
- AKAR JG. Response to Cardiac Resynchronization in Heart Failure: Just Go With the Myocardial Blood Flow? Journal Of Cardiovascular Electrophysiology 2010, 21: 1240-1241. PMID: 20662980, DOI: 10.1111/j.1540-8167.2010.01840.x.
- Chekakie M, Welles CC, Metoyer R, Ibrahim A, Shapira AR, Cytron J, Santucci P, Wilber DJ, Akar JG. Pericardial Fat Is Independently Associated With Human Atrial Fibrillation. Journal Of The American College Of Cardiology 2010, 56: 784-788. PMID: 20797492, DOI: 10.1016/j.jacc.2010.03.071.
- Martin J, Kartje W, Goldspink P, Akar J, Paul C, Sarkey J. Induction of Nogo‐A in Cardiomyopathy. The FASEB Journal 2010, 24: lb563-lb563. DOI: 10.1096/fasebj.24.1_supplement.lb563.
- Ip J, Waldo AL, Lip GY, Rothwell PM, Martin DT, Bersohn MM, Choucair WK, Akar JG, Wathen MS, Rohani P, Halperin JL, Investigators F. Multicenter randomized study of anticoagulation guided by remote rhythm monitoring in patients with implantable cardioverter-defibrillator and CRT-D devices: Rationale, design, and clinical characteristics of the initially enrolled cohort The IMPACT study. American Heart Journal 2009, 158: 364-370.e1. PMID: 19699858, DOI: 10.1016/j.ahj.2009.07.002.
- Santucci PA, Varma N, Cytron J, Akar JG, Wilber DJ, Chekakie M, Brysiewicz N. Electroanatomic mapping of postpacing intervals clarifies the complete active circuit and variants in atrial flutter. Heart Rhythm 2009, 6: 1586-1595. PMID: 19879536, DOI: 10.1016/j.hrthm.2009.08.010.
- VASAIWALA SC, FINN C, DELPRIORE J, LEYA F, GAGERMEIER J, AKAR JG, SANTUCCI P, DAJANI K, BOVA D, PICKEN MM, BASSO C, MARCUS F, WILBER DJ. Prospective Study of Cardiac Sarcoid Mimicking Arrhythmogenic Right Ventricular Dysplasia. Journal Of Cardiovascular Electrophysiology 2009, 20: 473-476. PMID: 19017339, DOI: 10.1111/j.1540-8167.2008.01351.x.
- AKAR JG, SINGH M, AUSEON AJ, WILBER DJ. Newly Diagnosed Arrhythmogenic Right Ventricular Dysplasia in an Octogenarian. Journal Of Cardiovascular Electrophysiology 2008, 19: 1316-1318. PMID: 18631265, DOI: 10.1111/j.1540-8167.2008.01241.x.
- Akar JG, Al-Chekakie MO, Fugate T, Moran L, Froloshki B, Varma N, Santucci P, Wilber DJ, Matsumura ME. Endothelial dysfunction in heart failure identifies responders to cardiac resynchronization therapy. Heart Rhythm 2008, 5: 1229-1235. PMID: 18774094, DOI: 10.1016/j.hrthm.2008.05.027.
- PORTER M, SPEAR W, AKAR JG, HELMS R, BRYSIEWICZ N, SANTUCCI P, WILBER DJ. Prospective Study of Atrial Fibrillation Termination During Ablation Guided by Automated Detection of Fractionated Electrograms. Journal Of Cardiovascular Electrophysiology 2008, 19: 613-620. PMID: 18462320, DOI: 10.1111/j.1540-8167.2008.01189.x.
- Akar JG, Jeske W, Wilber DJ. Acute Onset Human Atrial Fibrillation Is Associated With Local Cardiac Platelet Activation and Endothelial Dysfunction. Journal Of The American College Of Cardiology 2008, 51: 1790-1793. PMID: 18452786, DOI: 10.1016/j.jacc.2007.11.083.
- Wilber D, Akar J, Santucci P, Brysiewicz N. Electrogram‐Guided Approach to Ablation of Atrial Fibrillation. 2008, 240-255. DOI: 10.1002/9781444300185.ch18.
- Akar JG, Akar FG. Regulation of ion channels and arrhythmias in the ischemic heart. Journal Of Electrocardiology 2007, 40: s37-s41. PMID: 17993326, DOI: 10.1016/j.jelectrocard.2007.05.020.
- Joyal D, Leya F, Al-Chekakie M, Arab D, Dieter RS, Morshedi-Meibodi A, Lewis B, Steen L, Fareed J, Hoppenstead D, Akar JG. Presence of asymmetric dimethylarginine gradients across high-grade lesions in patients with coronary artery disease. Coronary Artery Disease 2007, 18: 471-475. PMID: 17700219, DOI: 10.1097/mca.0b013e32818be79c.
- Chekakie M, Thompson D, Wang F, Ganguly J, Chawla R, Akar J, Barron J. Do Electrocardiographic Changes during Dobutamine Stress Echocardiography Help Detect Coronary Allograft Vasculopathy in Heart Transplant Recipients? Journal Of Cardiac Failure 2007, 13: s117-s118. DOI: 10.1016/j.cardfail.2007.06.459.
- CHEKAKIE M, AKAR JG, WANG F, MURADI H, WU J, SANTUCCI P, VARMA N, WILBER DJ. The Effects of Statins and Renin‐Angiotensin System Blockers on Atrial Fibrillation Recurrence Following Antral Pulmonary Vein Isolation. Journal Of Cardiovascular Electrophysiology 2007, 18: 942-946. PMID: 17593228, DOI: 10.1111/j.1540-8167.2007.00887.x.
- AKAR JG, AL‐CHEKAKIE M, HAI A, BRYSIEWICZ N, PORTER M, VARMA N, SANTUCCI P, WILBER DJ. Surface Electrocardiographic Patterns and Electrophysiologic Characteristics of Atrial Flutter Following Modified Radiofrequency MAZE Procedures. Journal Of Cardiovascular Electrophysiology 2007, 18: 349-355. PMID: 17394449, DOI: 10.1111/j.1540-8167.2007.00761.x.
- Akar JG, Akar FG. Mapping arrhythmias in the failing heart: from Langendorff to patient. Journal Of Electrocardiology 2006, 39: s19-s23. PMID: 16920143, DOI: 10.1016/j.jelectrocard.2006.03.011.
- Akar JG. Predicting elevated defibrillation energy requirements in heart failure with reasonable probability. Heart Rhythm 2006, 3: 1017-1018. PMID: 16945793, DOI: 10.1016/j.hrthm.2006.06.015.
- Brysiewicz N, Akar J, Santucci P, Varma N, Helms R, Mark M, Saba M, Porter M, Wilber D. P6-84 Landmark registration versus surface registration of CT with real time map using CARTO-Merge in atrial fibrillation. Heart Rhythm 2006, 3: s329. DOI: 10.1016/j.hrthm.2006.02.985.
- Oza S, Porter M, Akar J, Santucci P, Varma N, Lu Y, Wilber D. P4-60 Electroanatomical substrate of ischemic cardiomyopathy with and without spontaneous ventricular tachycardia. Heart Rhythm 2006, 3: s238. DOI: 10.1016/j.hrthm.2006.02.715.
- Hoppensteadt D, Klein A, Iqbal O, Cunanan J, Wahi R, Wilber D, Akar J, Fareed J. AB3-4 Pathogenesis of atrial fibrillation and hypercoagulability: Potential role of inflammatory response. Heart Rhythm 2006, 3: s6. DOI: 10.1016/j.hrthm.2006.02.037.
- Hoppensteadt D, Klein A, Iqbal O, Cunanan J, Wahi R, Wilber D, Fareed J, Akar J. AB3-1 Human atrial fibrillation is associated with endothelial dysfunction and oxidative stress. Heart Rhythm 2006, 3: s5. DOI: 10.1016/j.hrthm.2006.02.034.
- Daniels DV, Lu YY, Morton JB, Santucci PA, Akar JG, Green A, Wilber DJ. Idiopathic Epicardial Left Ventricular Tachycardia Originating Remote From the Sinus of Valsalva. Circulation 2006, 113: 1659-1666. PMID: 16567566, DOI: 10.1161/circulationaha.105.611640.
- Wilber D, Lipman E, Madsen H, Lin A, Santucci P, Akar J, Anderson K, Dasari R, Joshi S, Gauri A. 8. Different Mapping Systems and Approaches for Ablation of Atrial Fibrillation. EP Europace 2005, 7: s14-s14. DOI: 10.1016/j.eupc.2005.08.054.
- Patel R, DiMarco J, Akar J, Voros S, Kramer C. Chagas Myocarditis and Syncope. Journal Of Cardiovascular Magnetic Resonance 2005, 7: 685-688. DOI: 10.1081/jcmr-200065627.
- Santucci P, Joshi S, Lin A, Akar J, Tierney S, Dasari R, Gauri A, Lipman E, Wilber D. Rapid assessment of isthmus block in patients with atrial flutter. Heart Rhythm 2005, 2: s277. DOI: 10.1016/j.hrthm.2005.02.872.
- Lipman E, Madsen N, Lin A, Santucci P, Akar J, Anderson K, Dasari R, Joshi S, Gauri A, Wilber D. Incidence and determinants of left atrial scar in patients with paroxysmal and persistent atrial fibrillation undergoing catheter ablation. Heart Rhythm 2005, 2: s12. DOI: 10.1016/j.hrthm.2005.02.048.
- Lin A, Morton J, Joshi S, Dasari R, Gauri A, Lipman E, Santucci P, Akar J, Wilber D. Safety and efficacy of catheter ablation of repetitive monomorphic ventricular tachycardia arising from the sinus of Valsalva guided by intracardiac echocardiography. Heart Rhythm 2005, 2: s36. DOI: 10.1016/j.hrthm.2005.02.123.
- Patel RA, DiMarco JP, Akar JG, Voros S, Kramer CM. Chagas myocarditis and syncope. Journal Of Cardiovascular Magnetic Resonance 2005, 7: 685-8. PMID: 16136859, DOI: 10.1081/jcmr-65627.
- AKAR J, WILBER D. Amiodarone and the Excitable Gap:. Journal Of Cardiovascular Electrophysiology 2004, 15: 1424-1425. PMID: 15610290, DOI: 10.1046/j.1540-8167.2004.04679.x.
- Akar JG, Everett TH, Ho R, Craft J, Haines DE, Somlyo AP, Somlyo AV. Intracellular Chloride Accumulation and Subcellular Elemental Distribution During Atrial Fibrillation. Circulation 2003, 107: 1810-1815. PMID: 12665494, DOI: 10.1161/01.cir.0000058462.23347.93.
- KOK LC, EVERETT TH, AKAR JG, HAINES DE. Effect of Heating on Pulmonary Veins:. Journal Of Cardiovascular Electrophysiology 2003, 14: 250-254. PMID: 12716105, DOI: 10.1046/j.1540-8167.2003.02490.x.
- Mell J, Jordan D, Xiao Y, Zheng Y, Akar J, Haines D. Wavelet Analysis of Atrial Fibrillation Electrograms. 2003, 2: ii - 357-ii - 360. DOI: 10.1109/icassp.2003.1202369.
- Xiao Y, Zheng Y, Jordan D, Akar J, Haines D. Parameter Estimation of Spiral Waves from Atrial Electrograms. 2003, 5: v - 245-v - 248. DOI: 10.1109/icassp.2003.1199914.
- Everett TH, Akar JG, Kok LC, Moorman JR, Haines DE. Use of global atrial fibrillation organization to optimize the success of burst pace termination. Journal Of The American College Of Cardiology 2002, 40: 1831-1840. PMID: 12446068, DOI: 10.1016/s0735-1097(02)02476-2.
- AKAR JG, EVERETT TH, KOK L, MOORMAN JR, HAINES DE. Effect of Electrical and Structural Remodeling on Spatiotemporal Organization in Acute and Persistent Atrial Fibrillation. Journal Of Cardiovascular Electrophysiology 2002, 13: 1027-1034. PMID: 12435191, DOI: 10.1046/j.1540-8167.2002.01027.x.
- AKAR J, DIMARCO J. Tachycardia with Atrioventricular Dissociation after Surgery for Single Ventricle. Journal Of Cardiovascular Electrophysiology 2001, 12: 1092-1093. PMID: 11573704, DOI: 10.1046/j.1540-8167.2001.01092.x.
- Akar J, Kok L, Haines D, DiMarco J, Mounsey J. Coexistence of type I atrial flutter and intra-atrial re-entrant tachycardia in patients with surgically corrected congenital heart disease. Journal Of The American College Of Cardiology 2001, 38: 377-384. PMID: 11499727, DOI: 10.1016/s0735-1097(01)01392-4.
- Everett T, Moorman J, Kok L, Akar J, Haines D. Assessment of Global Atrial Fibrillation Organization to Optimize Timing of Atrial Defibrillation. Circulation 2001, 103: 2857-2861. PMID: 11401945, DOI: 10.1161/01.cir.103.23.2857.
- Yale Cardiac ElectrophysiologyYale Physicians Building800 Howard Avenue, Fl 2New Haven, CT 06519
- Yale CardiologyYale New Haven Hospital20 York StreetNew Haven, CT 06510
- Yale Heart & Vascular Center500 West Putnam AvenueGreenwich, CT 06830
Biography
Joseph Akar, MD, PhD, is director of Yale Medicine’s Electrophysiology and Cardiac Arrhythmia Program. As an electrophysiologist, he treats the “electrical wiring” of the heart, which he describes as being not unlike the wiring in a house. The system must work properly, but the electricity in one of the chambers could get disrupted, he says. Heartbeat sequences that are too fast or slow—or otherwise irregular—can lead to serious problems, including stroke and sudden cardiac death. “It’s very important for the heart to have a uniform and consistent rhythm,” he says.
Dr. Akar treats a variety of issues that can develop in people of all ages, including those with otherwise healthy hearts. He uses techniques such as catheter ablation, a minimally invasive procedure that deliberately cauterizes the electrical short circuits in order to even out erratic rhythms, or arrhythmias. This technique has emerged as a treatment for complex problems such as refractory atrial fibrillation, which is the most common arrhythmia in humans, or ventricular tachycardia which is a major cause of sudden cardiac death. “The advent of ablation procedures for atrial fibrillation and ventricular tachycardia has really revolutionized the field,” Dr. Akar says.
He also has expertise in performing these ablations without fluoroscopy, an X-ray technique that can involve high radiation doses.
Patients who have heart rhythm problems should not hesitate to seek treatment, Dr. Akar says. “We’ve done a lot of work at Yale in refining our technology and techniques for the management of complex arrhythmias,” he says. “It’s been nothing but revolutionary as far as our ability to restore normal rhythms in cases that, in the past, we would never have dreamed that we would be able to.”
Titles
- Professor of Medicine (Cardiovascular Medicine)
- Director, Cardiac Electrophysiology Program, Internal Medicine
- Director, Complex Ablation Program
Education & Training
- FellowUniversity of Virginia (2004)
- PhDUniversity of Virginia (2004)
- FellowUniversity of Virginia (2002)
- ResidentYale-New Haven Hospital (1998)
- MDUniversity of Pittsburgh (1995)
Languages Spoken
- العربية (Arabic)
- English
- Français (French)
Additional Information
- AB of Internal Medicine, Clinical Cardiac Electrophysiology (2005, recertified: 2021)
- AB of Internal Medicine, Cardiovascular Disease (2003, recertified: 2013)
- Reiss M, Mulimani M, Luther S, Akar J, Rappel W, Akar F, Hummel J. PO-05-130 DEMONSTRATING THE IMPACT OF LESION ORIENTATION ON ABLATION EFFICIENCY IN AN ANISOTROPIC MODEL OF PERSISTENT ATRIAL FIBRILLATION. Heart Rhythm 2024, 21: s535. DOI: 10.1016/j.hrthm.2024.03.1365.
- Cacheux M, Velasco J, Wu X, Akar J, Young L, Akar F. MP-470551-008 ATRIAL FIBRILLATION IN MICE WITH AMPK DELETION IS MEDIATED BY TRIGGERED ACTIVITY FROM THE PULMONARY VEIN JUNCTION. Heart Rhythm 2024, 21: s107. DOI: 10.1016/j.hrthm.2024.03.1772.
- Kattel S, Tan Z, Lin Z, Friedman D, Mszar R, Zeitler E, Zei P, Bunch T, Mansour M, Akar J, Curtis J, Freeman J. Abstract 12614: Procedural Volume and Outcomes With Atrial Fibrillation Ablation: A Report From the NCDR AFib Registry. Circulation 2023, 148: a12614-a12614. DOI: 10.1161/circ.148.suppl_1.12614.
- Lamy J, Taoutel R, Chamoun R, Akar J, Niederer S, Mojibian H, Huber S, Baldassarre L, Meadows J, Peters D. Atrial fibrosis by cardiac MRI is a correlate for atrial stiffness in patients with atrial fibrillation. The International Journal Of Cardiovascular Imaging 2023, 40: 107-117. PMID: 37857929, DOI: 10.1007/s10554-023-02968-x.
- Perike S, Gonzalez-Gonzalez F, Abu-Taha I, Damen F, Hanft L, Lizama K, Aboonabi A, Capote A, Aguilar-Sanchez Y, Levin B, Han Z, Sridhar A, Grand J, Martin J, Akar J, Warren C, Solaro R, Ong S, Darbar D, McDonald K, Goergen C, Wolska B, Dobrev D, Wehrens X, McCauley M. PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation. Circulation Research 2023, 133: 758-771. PMID: 37737016, PMCID: PMC10616980, DOI: 10.1161/circresaha.123.322516.
- Gonzalez-Gonzalez F, perike S, Abu-Taha I, Damen F, Lizama K, Aboonabi A, Capote A, Aguilar-Sanchez Y, Levin B, Han Z, Sridhar A, Grand J, Martin J, Akar J, Warren C, Solaro R, Ong S, Darbar D, Goergen C, Wolska B, Dobrev D, Wehrens X, McCauley M. Abstract EC.02: Myosin Light Chain Dephosphorylation By Ppp1r12c Promotes Atria Hypocontractility In Atrial Fibrillation. Circulation Research 2023, 133 DOI: 10.1161/res.133.suppl_1.ec.02.
- Darden D, Aldaas O, Du C, Munir M, Feld G, Pothineni N, Gopinathannair R, Lakkireddy D, Curtis J, Freeman J, Akar J, Hsu J. In-hospital complications associated with pulmonary vein isolation with adjunctive lesions: the NCDR AFib Ablation Registry. EP Europace 2023, 25: euad124. PMID: 37184436, PMCID: PMC10228609, DOI: 10.1093/europace/euad124.
- Kawkabani N, Farah R, Boustros O, Khoury A, Ghanem M, Khalil B, Akar J. PO-02-202 CORONARY SINUS PRESSURE FOLLOWING RETROGRADE CARDIOPLEGIA PREDICTS POSTOPERATIVE ATRIAL FIBRILLATION. Heart Rhythm 2023, 20: s311-s312. DOI: 10.1016/j.hrthm.2023.03.1585.
- Chui P, Lan Z, Freeman J, Enriquez A, Khera R, Akar J, Masoudi F, Ong E, Curtis J. Variation in hospital use of cardiac resynchronization therapy-defibrillator among eligible patients and association with clinical outcomes. Heart Rhythm 2023, 20: 1000-1008. PMID: 36963741, DOI: 10.1016/j.hrthm.2023.03.022.
- Hsu J, Darden D, Du C, Marine J, Nichols S, Marcus G, Natale A, Noseworthy P, Selzman K, Varosy P, Masoudi F, Freeman J, Curtis J, Akar J, Kowey P. Initial Findings From the National Cardiovascular Data Registry of Atrial Fibrillation Ablation Procedures. Journal Of The American College Of Cardiology 2023, 81: 867-878. PMID: 36858707, DOI: 10.1016/j.jacc.2022.11.060.
- Ginder C, Li J, Halperin J, Akar J, Martin D, Chattopadhyay I, Upadhyay G. Predicting Malignant Ventricular Arrhythmias Using Real-Time Remote Monitoring. Journal Of The American College Of Cardiology 2023, 81: 949-961. PMID: 36889873, DOI: 10.1016/j.jacc.2022.12.024.
- Darden D, Aldaas O, Du C, Feld G, Pothineni K, Gopinathannair R, Lakkireddy D, Curtis J, Freeman J, Akar J, Hsu J. Abstract 15360: Characteristics and In-Hospital Outcomes of Patients Undergoing Pulmonary Vein Isolation With and Without Adjunctive Lesions: Insights From the Ncdr Afib Ablation Registry. Circulation 2022, 146: a15360-a15360. DOI: 10.1161/circ.146.suppl_1.15360.
- Gonzalez F, perike S, Damen F, Capote A, Alsina K, Levin B, Sridhar A, Grand J, Martin J, Akar J, Warren C, Solaro R, Darbar D, Goergen C, Wolska B, Wehrens X, McCauley M. Abstract 13258: Myosin Light Chain Dephosphorylation by Ppp1r12c Promotes Atrial Hypocontractility in Atrial Fibrillation. Circulation 2022, 146: a13258-a13258. DOI: 10.1161/circ.146.suppl_1.13258.
- Mszar R, Friedman D, Ong E, Du C, Wang Y, Zeitler E, Cunningham S, Akar J, Curtis J, Freeman J. Sex-based differences in atrial fibrillation ablation adverse events. Heart 2022, 109: 595-605. PMID: 36104219, DOI: 10.1136/heartjnl-2022-321192.
- Cacheux M, Ma Y, Wu X, Akar J, Young L, Akar F. Abstract P1098: Atrial Deletion Of AMPK Promotes Atrial Oxidative Stress And The Formation Of Delayed Afterdepolarizations Within The Inter-atrial Pulmonary Vein Junction. Circulation Research 2022, 131: ap1098-ap1098. DOI: 10.1161/res.131.suppl_1.p1098.
- Ziki M, Hummel J, Lampert R, Akar J. PO-657-07 SPONTANEOUS RESTORATION OF SINUS RHYTHM AFTER INTER ATRIAL SHUNT PLACEMENT IN A PATIENT WITH LONGSTANDING PERSISTENT ATRIAL FIBRILLATION. Heart Rhythm 2022, 19: s273-s274. DOI: 10.1016/j.hrthm.2022.03.295.
- Gonzalez-Gonzalez F, Perike S, Damen F, Capote A, Alsina K, Levin B, Sridhar A, Grand J, Martin J, Akar J, Warren C, Solaro J, Darbar D, Goergen C, Wolska B, Wehrens X, McCauley M. Abstract P458: Myosin Light Chain Dephosphorylation By Ppp1r12c Promotes Atrial Hypocontractility In Atrial Fibrillation. Circulation Research 2021, 129: ap458-ap458. DOI: 10.1161/res.129.suppl_1.p458.
- Strauss B, Obus E, Katz M, Fargnoli A, Cacheux M, Akar J, Hummel J, Sassi Y, Akar F. B-PO02-027 RIGHT PREDOMINANT ELECTRICAL REMODELING IN A PURE MODEL OF PULMONARY HYPERTENSION PROMOTES REENTRANT ARRHYTHMIAS. Heart Rhythm 2021, 18: s106. DOI: 10.1016/j.hrthm.2021.06.284.
- Ziki M, Bhat N, Neogi A, Abboud J, Chouairi S, Ugwu N, Driscoll T, Liu Y, Smith E, Schwartz M, Akar J, Mani A. B-AB13-03 NOVEL ROLE OF PDE4DIP IN FAMILIAL ATRIAL FIBRILLATION WITH SLOW VENTRICULAR RESPONSE. Heart Rhythm 2021, 18: s26. DOI: 10.1016/j.hrthm.2021.06.078.
- Gonzalez-Gonzalez F, Srikanth P, Capote A, Katherina M A, Levin B, Sridhar A, Jacob G, Martin J, Akar J, Warren C, Solaro J, Darbar D, Goergen C, Wolska B, Wehrens X, McCauley M. Abstract P780: Myosin Light Chain Dephosphorylation by Ppp1r12c Promotes Atrial Hypocontractility in Atrial Fibrillation. Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.p780.
- Friedman D, Parzynski C, Heist E, Russo A, Ranasinghe I, Zeitler E, Minges K, Akar J, Freeman J, Curtis J, Al-khatib S. Abstract 16496: Longitudinal Outcomes After Implantation of a Subcutaneous or Transvenous Implantable Cardioverter Defibrillator in Older Patients: A Report From the National Cardiovascular Data Registry. Circulation 2020, 142 DOI: 10.1161/circ.142.suppl_3.16496.
- Hsu J, Akar J, Marine J, Nichols S, Marcus G, Natale A, Noseworthy P, selzman K, Varosy P, Masoudi F, Du C, Freeman J, Curtis J, Kowey P. Abstract 12785: The American College of Cardiology's NCDR Afib Ablation Registry: A Summary of Initial Data Including Patient Characteristics, Procedural Characteristics, and Adverse Events. Circulation 2020, 142 DOI: 10.1161/circ.142.suppl_3.12785.
- Hummel JP, Maraj I, Taoutel R, Chamoun R, Workman VK, Tran L, Abboud JM, Afif C, Chouairi S, Delvecchio A, Howes CJ, Enriquez AD, Akar JG. Temporal Trends in Arrhythmogenicity Related to Treatment of COVID-19 Infection. Circulation Arrhythmia And Electrophysiology 2020, 13: e008841-e008841. PMID: 32931318, PMCID: PMC7566294, DOI: 10.1161/circep.120.008841.
- Hummel JP, Akar JG. Reply to: “QT prolongation with hydroxychloroquine and azithromycin for the treatment of COVID‐19: The need for pharmacogenetic insights”. Journal Of Cardiovascular Electrophysiology 2020, 31: 2795-2795. PMID: 32864768, DOI: 10.1111/jce.14721.
- Workman V, Freeman JV, Obasare ER, Jain S, Ganeshan R, Burr A, Blitzer M, Akar J, Lampert R. Risk of COVID-19 infection after cardiac electrophysiology procedures. Heart Rhythm O2 2020, 1: 239-242. PMID: 32904452, PMCID: PMC7455246, DOI: 10.1016/j.hroo.2020.08.006.
- Maraj I, Hummel JP, Taoutel R, Chamoun R, Workman V, Li C, Tran L, DelVecchio A, Howes C, Akar JG. Incidence and determinants of QT interval prolongation in COVID‐19 patients treated with hydroxychloroquine and azithromycin. Journal Of Cardiovascular Electrophysiology 2020, 31: 1904-1907. PMID: 32485061, PMCID: PMC7300464, DOI: 10.1111/jce.14594.
- Jain S, Workman V, Ganeshan R, Obasare ER, Burr A, DeBiasi RM, Freeman JV, Akar J, Lampert R, Rosenfeld LE. Enhanced electrocardiographic monitoring of patients with Coronavirus Disease 2019. Heart Rhythm 2020, 17: 1417-1422. PMID: 32387247, PMCID: PMC7200355, DOI: 10.1016/j.hrthm.2020.04.047.
- Ortiz-Leon XA, Posada-Martinez EL, Trejo-Paredes MC, Ivey-Miranda JB, Pereira J, Crandall I, DaSilva P, Bouman E, Brooks A, Gerardi C, Ugonabo I, Chen W, Houle H, Akar JG, Lin BA, McNamara RL, Lombo-Lievano B, Arias-Godinez JA, Sugeng L. Understanding tricuspid valve remodelling in atrial fibrillation using three-dimensional echocardiography. European Heart Journal - Cardiovascular Imaging 2020, 21: 747-755. PMID: 32372089, DOI: 10.1093/ehjci/jeaa058.
- Yu R, Liu N, Lu J, Zhao X, Hu Y, Zhang J, Xu F, Tang R, Bai R, Akar JG, Dong J, Ma C. 3-Dimensional Transseptal Puncture Based on Electrographic Characteristics of Fossa Ovalis A Fluoroscopy-Free and Echocardiography-Free Method. JACC Cardiovascular Interventions 2020, 13: 1223-1232. PMID: 32438994, DOI: 10.1016/j.jcin.2020.03.015.
- Friedman D, Pokorney S, Ghanem A, Marcello S, Kalsekar I, Yadalam S, Akar J, Freeman J, Goldstein L, Khanna R, Piccini J. TT2 CARDIAC PERFORATION AMONG PATIENTS WITH ATRIAL FIBRILLATION UNDERGOING ABLATION: WHAT ARE THE UNDERLYING PREDICTORS? Value In Health 2020, 23: s385-s386. DOI: 10.1016/j.jval.2020.04.1502.
- Dhruva SS, Ross JS, Akar JG, Caldwell B, Childers K, Chow W, Ciaccio L, Coplan P, Dong J, Dykhoff HJ, Johnston S, Kellogg T, Long C, Noseworthy PA, Roberts K, Saha A, Yoo A, Shah ND. Aggregating multiple real-world data sources using a patient-centered health-data-sharing platform. Npj Digital Medicine 2020, 3: 60. PMID: 32352038, PMCID: PMC7170944, DOI: 10.1038/s41746-020-0265-z.
- Freeman JV, Varosy P, Price MJ, Slotwiner D, Kusumoto FM, Rammohan C, Kavinsky CJ, Turi ZG, Akar J, Koutras C, Curtis JP, Masoudi FA. The NCDR Left Atrial Appendage Occlusion Registry. Journal Of The American College Of Cardiology 2020, 75: 1503-1518. PMID: 32238316, PMCID: PMC7205034, DOI: 10.1016/j.jacc.2019.12.040.
- Friedman DJ, Pokorney SD, Ghanem A, Marcello S, Kalsekar I, Yadalam S, Akar JG, Freeman JV, Goldstein L, Khanna R, Piccini JP. Predictors of Cardiac Perforation With Catheter Ablation of Atrial Fibrillation. JACC Clinical Electrophysiology 2020, 6: 636-645. PMID: 32553212, DOI: 10.1016/j.jacep.2020.01.011.
- Ortiz-Leon X, Posada E, Trejo M, Miranda J, Pereira J, Crandall I, DaSilva P, Bouman E, Brooks A, Gerardi C, Houle H, Akar J, Lin B, McNamara R, Lombo B, Arias-Godínez J, Sugeng L. TRICUSPID AND MITRAL REMODELING IN ATRIAL FIBRILLATION: A THREE-DIMENSIONAL ECHOCARDIOGRAPHIC STUDY. Journal Of The American College Of Cardiology 2020, 75: 1706. DOI: 10.1016/s0735-1097(20)32333-0.
- Ortiz-Leon X, Posada E, Chen W, Bregasi A, Crandall I, Pereira J, Miranda J, Akar J, Lin B, McNamara R, Freeman J, Curtis J, Arias-Godínez J, Sugeng L. CHANGES OF LEFT ATRIAL APPENDAGE ORIFICE FOLLOWING PERCUTANEOUS LEFT ATRIAL APPENDAGE CLOSURE USING THREE-DIMENSIONAL ECHOCARDIOGRAPHY. Journal Of The American College Of Cardiology 2020, 75: 1708. DOI: 10.1016/s0735-1097(20)32335-4.
- Akar J, Charif M, Dib G, Abboud J, Chouairi S. IVABRADINE USE MAY BE ASSOCIATED WITH INCREASED BURDEN OF IDIOPATHIC PREMATURE CONTRACTIONS. Journal Of The American College Of Cardiology 2020, 75: 2640. DOI: 10.1016/s0735-1097(20)33267-8.
- Baher A, Buck B, Fanarjian M, Mounsey J, Gehi A, Chung E, Akar FG, Webber CL, Akar JG, Hummel JP. Recurrence quantification analysis of complex‐fractionated electrograms differentiates active and passive sites during atrial fibrillation. Journal Of Cardiovascular Electrophysiology 2019, 30: 2229-2238. PMID: 31507008, DOI: 10.1111/jce.14161.
- Hummel JP, Leipold RJ, Amorosi SL, Bao H, Deger KA, Jones PW, Kansal AR, Ott LS, Stern S, Stein K, Curtis JP, Akar JG. Outcomes and costs of remote patient monitoring among patients with implanted cardiac defibrillators: An economic model based on the PREDICT RM database. Journal Of Cardiovascular Electrophysiology 2019, 30: 1066-1077. PMID: 30938894, PMCID: PMC6850124, DOI: 10.1111/jce.13934.
- Hummel JP, Kadado AJ, Baker M, Gehi AK, Mounsey JP, Sadaf MI, Enriquez AD, Freeman JV, Akar JG. Atrial Fibrillation Thermographic and Endoscopic Monitoring of Patients: Safety Algorithm for the Esophagus. Circulation Arrhythmia And Electrophysiology 2018, 11: e006814. PMID: 30562101, DOI: 10.1161/circep.118.006814.
- Kadado AJ, Akar JG, Hummel JP. Luminal esophageal temperature monitoring to reduce esophageal thermal injury during catheter ablation for atrial fibrillation: A review. Trends In Cardiovascular Medicine 2018, 29: 264-271. PMID: 30282588, DOI: 10.1016/j.tcm.2018.09.010.
- Hummel JP, Akar JG, Baher A, Webber CL. New skip parameter to facilitate recurrence quantification of signals comprised of multiple components. Chaos An Interdisciplinary Journal Of Nonlinear Science 2018, 28: 085718. PMID: 30180597, DOI: 10.1063/1.5024845.
- Friedman DJ, Parzynski CS, Heist EK, Russo AM, Akar JG, Freeman JV, Curtis JP, Al-Khatib SM. Ventricular Fibrillation Conversion Testing After Implantation of a Subcutaneous Implantable Cardioverter Defibrillator. Circulation 2018, 137: 2463-2477. PMID: 29463509, PMCID: PMC5988932, DOI: 10.1161/circulationaha.117.032167.
- Kadado AJ, Freeman J, Akar JG. Postoperative Atrial Fibrillation and Maslow’s Hammer. Anesthesia & Analgesia 2018, 126: 19-20. PMID: 29252478, DOI: 10.1213/ane.0000000000002414.
- Karam BS, Chavez-Moreno A, Koh W, Akar JG, Akar FG. Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes. Cardiovascular Diabetology 2017, 16: 120. PMID: 28962617, PMCID: PMC5622555, DOI: 10.1186/s12933-017-0604-9.
- Calkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen PS, Chen SA, Chung MK, Nielsen J, Curtis AB, Davies DW, Day JD, d’Avila A, de Groot N, Di Biase L, Duytschaever M, Edgerton JR, Ellenbogen KA, Ellinor PT, Ernst S, Fenelon G, Gerstenfeld EP, Haines DE, Haissaguerre M, Helm RH, Hylek E, Jackman WM, Jalife J, Kalman JM, Kautzner J, Kottkamp H, Kuck KH, Kumagai K, Lee R, Lewalter T, Lindsay BD, Macle L, Mansour M, Marchlinski FE, Michaud GF, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds MR, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao HM, Verma A, Wilber DJ, Yamane T, Blomström-Lundqvist C, De Paola A, Kistler P, Lip G, Peters N, Pisani C, Raviele A, Saad E, Satomi K, Stiles M, Willems S. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation. EP Europace 2017, 20: e1-e160. PMID: 29016840, PMCID: PMC5834122, DOI: 10.1093/europace/eux274.
- Calkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen PS, Chen SA, Chung MK, Nielsen JC, Curtis AB, Wyn Davies D, Day JD, d’Avila A, de Groot N, Di Biase L, Duytschaever M, Edgerton JR, Ellenbogen KA, Ellinor PT, Ernst S, Fenelon G, Gerstenfeld EP, Haines DE, Haissaguerre M, Helm RH, Hylek E, Jackman WM, Jalife J, Kalman JM, Kautzner J, Kottkamp H, Kuck KH, Kumagai K, Lee R, Lewalter T, Lindsay BD, Macle L, Mansour M, Marchlinski FE, Michaud GF, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds MR, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao HM, Verma A, Wilber DJ, Yamane T. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary. Journal Of Interventional Cardiac Electrophysiology 2017, 50: 1-55. PMID: 28914401, PMCID: PMC5633646, DOI: 10.1007/s10840-017-0277-z.
- Calkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen PS, Chen SA, Chung MK, Nielsen JC, Curtis AB, Davies DW, Day JD, d'Avila A, de Groot NMSN, Di Biase L, Duytschaever M, Edgerton JR, Ellenbogen KA, Ellinor PT, Ernst S, Fenelon G, Gerstenfeld EP, Haines DE, Haissaguerre M, Helm RH, Hylek E, Jackman WM, Jalife J, Kalman JM, Kautzner J, Kottkamp H, Kuck KH, Kumagai K, Lee R, Lewalter T, Lindsay BD, Macle L, Mansour M, Marchlinski FE, Michaud GF, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds MR, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao HM, Verma A, Wilber DJ, Yamane T. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary. EP Europace 2017, 20: 157-208. PMID: 29016841, PMCID: PMC5892164, DOI: 10.1093/europace/eux275.
- Calkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen PS, Chen SA, Chung MK, Nielsen JC, Curtis AB, Davies DW, Day JD, d'Avila A, de Groot NMSN, Di Biase L, Duytschaever M, Edgerton JR, Ellenbogen KA, Ellinor PT, Ernst S, Fenelon G, Gerstenfeld EP, Haines DE, Haissaguerre M, Helm RH, Hylek E, Jackman WM, Jalife J, Kalman JM, Kautzner J, Kottkamp H, Kuck KH, Kumagai K, Lee R, Lewalter T, Lindsay BD, Macle L, Mansour M, Marchlinski FE, Michaud GF, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds MR, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao HM, Verma A, Wilber DJ, Yamane T. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary. Journal Of Arrhythmia 2017, 33: 369-409. PMID: 29021841, PMCID: PMC5634725, DOI: 10.1016/j.joa.2017.08.001.
- Calkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen PS, Chen SA, Chung MK, Nielsen JC, Curtis AB, Davies DW, Day JD, d'Avila A, de Groot NMSN, Di Biase L, Duytschaever M, Edgerton JR, Ellenbogen KA, Ellinor PT, Ernst S, Fenelon G, Gerstenfeld EP, Haines DE, Haissaguerre M, Helm RH, Hylek E, Jackman WM, Jalife J, Kalman JM, Kautzner J, Kottkamp H, Kuck KH, Kumagai K, Lee R, Lewalter T, Lindsay BD, Macle L, Mansour M, Marchlinski FE, Michaud GF, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds MR, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao HM, Verma A, Wilber DJ, Yamane T. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary. Heart Rhythm 2017, 14: e445-e494. PMID: 31631881, DOI: 10.1016/j.hrthm.2017.07.009.
- Calkins H, Hindricks G, Cappato R, Kim Y, Saad E, Aguinaga L, Akar J, Badhwar V, Brugada J, Camm J, Chen P, Chen S, Chung M, Nielsen J, Curtis A, Davies D, Day J, d’Avila A, de Groot N, Di Biase L, Duytschaever M, Edgerton J, Ellenbogen K, Ellinor P, Ernst S, Fenelon G, Gerstenfeld E, Haines D, Haissaguerre M, Helm R, Hylek E, Jackman W, Jalife J, Kalman J, Kautzner J, Kottkamp H, Kuck K, Kumagai K, Lee R, Lewalter T, Lindsay B, Macle L, Mansour M, Marchlinski F, Michaud G, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds M, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao H, Verma A, Wilber D, Yamane T. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation. Journal Of Arrhythmia 2017 DOI: 10.1016/j.joa.2017.07.001.
- Hummel JP, Baher A, Buck B, Fanarjian M, Webber CL, Akar JG. A method for quantifying recurrent patterns of local wavefront direction during atrial fibrillation. Computers In Biology And Medicine 2017, 89: 497-504. PMID: 28889077, DOI: 10.1016/j.compbiomed.2017.08.027.
- Ross JS, Bates J, Parzynski CS, Akar JG, Curtis JP, Desai NR, Freeman JV, Gamble GM, Kuntz R, Li SX, Marinac-Dabic D, Masoudi FA, Normand ST, Ranasinghe I, Shaw RE, Krumholz HM. Can machine learning complement traditional medical device surveillance? A case-study of dual-chamber implantable cardioverter–defibrillators. Medical Devices Evidence And Research 2017, 10: 165-188. PMID: 28860874, PMCID: PMC5566316, DOI: 10.2147/mder.s138158.
- Kadado AJ, Akar JG, Hummel JP. Arrhythmias after left ventricular assist device implantation: Incidence and management. Trends In Cardiovascular Medicine 2017, 28: 41-50. PMID: 28734595, DOI: 10.1016/j.tcm.2017.07.002.
- Hummel J, Leipold R, Amorosi, Bao H, Deger K, Jones P, Stivland T, Kansal A, Ott L, Stern S, Stein K, Curtis J, Akar J. P1639Outcomes and costs of remote patient monitoring among patients with implanted cardiac defibrillators: an economic model based on the PREDICt RM database. EP Europace 2017, 19: iii353-iii353. DOI: 10.1093/ehjci/eux158.265.
- Ziki M, Seidelmann SB, Smith E, Atteya G, Jiang Y, Fernandes RG, Marieb MA, Akar JG, Mani A. Deleterious protein‐altering mutations in the SCN10A voltage‐gated sodium channel gene are associated with prolonged QT. Clinical Genetics 2017, 93: 741-751. PMID: 28407228, PMCID: PMC5640462, DOI: 10.1111/cge.13036.
- Calkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen PS, Chen SA, Chung MK, Nielsen JC, Curtis AB, Davies DW, Day JD, d'Avila A, de Groot NMSN, Di Biase L, Duytschaever M, Edgerton JR, Ellenbogen KA, Ellinor PT, Ernst S, Fenelon G, Gerstenfeld EP, Haines DE, Haissaguerre M, Helm RH, Hylek E, Jackman WM, Jalife J, Kalman JM, Kautzner J, Kottkamp H, Kuck KH, Kumagai K, Lee R, Lewalter T, Lindsay BD, Macle L, Mansour M, Marchlinski FE, Michaud GF, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds MR, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao HM, Verma A, Wilber DJ, Yamane T. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation. Heart Rhythm 2017, 14: e275-e444. PMID: 28506916, PMCID: PMC6019327, DOI: 10.1016/j.hrthm.2017.05.012.
- Calkins H, Hindricks G, Cappato R, Kim Y, Saad E, Aguinaga L, Akar J, Badhwar V, Brugada J, Camm J, Chen P, Chen S, Chung M, Nielsen J, Curtis A, Davies D, Day J, d'Avila A, de Groot N, Di Biase L, Duytschaever M, Edgerton J, Ellenbogen K, Ellinor P, Ernst S, Fenelon G, Gerstenfeld E, Haines D, Haissaguerre M, Helm R, Hylek E, Jackman W, Jalife J, Kalman J, Kautzner J, Kottkamp H, Kuck K, Kumagai K, Lee R, Lewalter T, Lindsay B, Macle L, Mansour M, Marchlinski F, Michaud G, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds M, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao H, Verma A, Wilber D, Yamane T. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation. Journal Of Arrhythmia 2017 DOI: 10.1016/j.joa.2017.05.001.
- Al-Chekakie MO, Bao H, Jones PW, Stein KM, Marzec L, Varosy PD, Masoudi FA, Curtis JP, Akar JG. Addition of Blood Pressure and Weight Transmissions to Standard Remote Monitoring of Implantable Defibrillators and its Association with Mortality and Rehospitalization. Circulation Cardiovascular Quality And Outcomes 2017, 10: e003087. PMID: 28506978, DOI: 10.1161/circoutcomes.116.003087.
- Ziki M, Seidelmann S, Smith E, Narayanan A, Atteya G, Jiang Y, Gil-Fernandez R, Marieb M, Akar J, Mani A. DELETERIOUS MUTATIONS IN SCN10A ARE ASSOCIATED WITH LONG QT SYNDROME. Journal Of The American College Of Cardiology 2017, 69: 509. DOI: 10.1016/s0735-1097(17)33898-6.
- Lansky AJ, Messé SR, Brickman AM, Dwyer M, van der Worp H, Lazar RM, Pietras CG, Abrams KJ, McFadden E, Petersen NH, Browndyke J, Prendergast B, Ng VG, Cutlip DE, Kapadia S, Krucoff MW, Linke A, Moy C, Schofer J, van Es GA, Virmani R, Popma J, Parides MK, Kodali S, Bilello M, Zivadinov R, Akar J, Furie KL, Gress D, Voros S, Moses J, Greer D, Forrest JK, Holmes D, Kappetein AP, Mack M, Baumbach A. Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials. European Heart Journal 2017, 39: 1687-1697. PMID: 28171522, PMCID: PMC6251670, DOI: 10.1093/eurheartj/ehx037.
- Freeman JV, Wang Y, Akar J, Desai N, Krumholz H. National Trends in Atrial Fibrillation Hospitalization, Readmission, and Mortality for Medicare Beneficiaries, 1999–2013. Circulation 2017, 135: 1227-1239. PMID: 28148599, DOI: 10.1161/circulationaha.116.022388.
- Lansky AJ, Messé SR, Brickman AM, Dwyer M, van der Worp HB, Lazar RM, Pietras CG, Abrams KJ, McFadden E, Petersen NH, Browndyke J, Prendergast B, Ng VG, Cutlip DE, Kapadia S, Krucoff MW, Linke A, Moy CS, Schofer J, van Es GA, Virmani R, Popma J, Parides MK, Kodali S, Bilello M, Zivadinov R, Akar J, Furie KL, Gress D, Voros S, Moses J, Greer D, Forrest JK, Holmes D, Kappetein AP, Mack M, Baumbach A. Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials An Academic Research Consortium Initiative. Journal Of The American College Of Cardiology 2017, 69: 679-691. PMID: 28183511, DOI: 10.1016/j.jacc.2016.11.045.
- Seidelmann SB, Smith E, Subrahmanyan L, Dykas D, Abou Ziki MD, Azari B, Hannah-Shmouni F, Jiang Y, Akar JG, Marieb M, Jacoby D, Bale AE, Lifton RP, Mani A. Application of Whole Exome Sequencing in the Clinical Diagnosis and Management of Inherited Cardiovascular Diseases in Adults. Circulation Genomic And Precision Medicine 2017, 10: e001573. PMID: 28087566, PMCID: PMC5245580, DOI: 10.1161/circgenetics.116.001573.
- Lip GY, Waldo AL, Ip J, Martin DT, Bersohn MM, Choucair WK, Akar JG, Wathen M, Halperin JL, Investigators I. Determinants of Time in Therapeutic Range in Patients Receiving Oral Anticoagulants (A Substudy of IMPACT). The American Journal Of Cardiology 2016, 118: 1680-1684. PMID: 27665206, DOI: 10.1016/j.amjcard.2016.08.047.
- Curtis JP, Akar JG. A Fresh Perspective on Atrial Fibrillation∗. Journal Of The American College Of Cardiology 2016, 68: 905-907. PMID: 27561763, DOI: 10.1016/j.jacc.2016.06.019.
- Goette A, Kalman JM, Aguinaga L, Akar J, Cabrera JA, Chen SA, Chugh SS, Corradi D, D'Avila A, Dobrev D, Fenelon G, Gonzalez M, Hatem SN, Helm R, Hindricks G, Ho SY, Hoit B, Jalife J, Kim Y, Lip GY, Ma C, Marcus GM, Murray K, Nogami A, Sanders P, Uribe W, Van Wagoner DR, Nattel S, Document Reviewers: Osmar A. Centurion K, Shantsila R. EHRA/HRS/APHRS/SOLAECE expert consensus on Atrial cardiomyopathies: Definition, characterisation, and clinical implication. Journal Of Arrhythmia 2016, 32: 247-278. PMID: 27588148, PMCID: PMC4996910, DOI: 10.1016/j.joa.2016.05.002.
- Goette A, Kalman JM, Aguinaga L, Akar J, Cabrera JA, Chen SA, Chugh SS, Corradi D, D'Avila A, Dobrev D, Fenelon G, Gonzalez M, Hatem SN, Helm R, Hindricks G, Ho SY, Hoit B, Jalife J, Kim YH, Lip GY, Ma CS, Marcus GM, Murray K, Nogami A, Sanders P, Uribe W, Van Wagoner DR, Nattel S, Centurion O, Kuck K, Patton K, Sapp J, Stiles M, Svendsen J, Upadhyay G, Shantsila A. EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication. EP Europace 2016, 18: 1455-1490. PMID: 27402624, PMCID: PMC6392440, DOI: 10.1093/europace/euw161.
- Akar JG, Hummel JP. Editorial commentary: Virtual medicine—A better reality? Trends In Cardiovascular Medicine 2016, 26: 731-732. PMID: 27737760, DOI: 10.1016/j.tcm.2016.06.012.
- Goette A, Kalman JM, Aguinaga L, Akar J, Cabrera JA, Chen SA, Chugh SS, Corradi D, D’Avila A, Dobrev D, Fenelon G, Gonzalez M, Hatem SN, Helm R, Hindricks G, Ho SY, Hoit B, Jalife J, Kim YH, Lip GY, Ma CS, Marcus GM, Murray K, Nogami A, Sanders P, Uribe W, Van Wagoner DR, Nattel S. EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: Definition, characterization, and clinical implication. Heart Rhythm 2016, 14: e3-e40. PMID: 27320515, PMCID: PMC5548137, DOI: 10.1016/j.hrthm.2016.05.028.
- Ranasinghe I, Parzynski CS, Freeman JV, Dreyer RP, Ross JS, Akar JG, Krumholz HM, Curtis JP. Long-Term Risk for Device-Related Complications and Reoperations After Implantable Cardioverter-Defibrillator Implantation: An Observational Cohort Study. Annals Of Internal Medicine 2016, 165: 20-29. PMID: 27135392, DOI: 10.7326/m15-2732.
- Akar J, El-Hachem G, Ayyash B, Kadado A, Nabbout R, Lamaa N, Bao H, Khalil B. BASELINE RED CELL DISTRIBUTION WIDTH INDEPENDENTLY PREDICTS POST-OPERATIVE ATRIAL FIBRILLATION. Journal Of The American College Of Cardiology 2016, 67: 729. DOI: 10.1016/s0735-1097(16)30730-6.
- Kim GE, Ross JL, Xie C, Su KN, Zaha VG, Wu X, Palmeri M, Ashraf M, Akar JG, Russell KS, Akar FG, Young LH. LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation. Cardiovascular Research 2015, 108: 197-208. PMID: 26378152, PMCID: PMC4571838, DOI: 10.1093/cvr/cvv212.
- Akar JG, Bao H, Jones PW, Wang Y, Varosy PD, Masoudi FA, Stein KM, Saxon LA, Normand SL, Curtis JP. Use of Remote Monitoring Is Associated With Lower Risk of Adverse Outcomes Among Patients With Implanted Cardiac Defibrillators. Circulation Arrhythmia And Electrophysiology 2015, 8: 1173-1180. PMID: 26092577, DOI: 10.1161/circep.114.003030.
- Slotwiner D, Varma N, Akar JG, Annas G, Beardsall M, Fogel RI, Galizio NO, Glotzer TV, Leahy RA, Love CJ, McLean RC, Mittal S, Morichelli L, Patton KK, Raitt MH, Ricci RP, Rickard J, Schoenfeld MH, Serwer GA, Shea J, Varosy P, Verma A, Yu CM. HRS Expert Consensus Statement on remote interrogation and monitoring for cardiovascular implantable electronic devices. Heart Rhythm 2015, 12: e69-e100. PMID: 25981148, DOI: 10.1016/j.hrthm.2015.05.008.
- Akar JG, Marieb MA. Atrial Fibrillation and Thrombogenesis Innocent Bystander or Guilty Accomplice?∗. JACC Clinical Electrophysiology 2015, 1: 218-219. PMID: 29759367, DOI: 10.1016/j.jacep.2015.05.003.
- Martin DT, Bersohn MM, Waldo AL, Wathen MS, Choucair WK, Lip GY, Ip J, Holcomb R, Akar JG, Halperin JL. Randomized trial of atrial arrhythmia monitoring to guide anticoagulation in patients with implanted defibrillator and cardiac resynchronization devices. European Heart Journal 2015, 36: 1660-1668. PMID: 25908774, DOI: 10.1093/eurheartj/ehv115.
- Altaf F, Akar J, Lichtman J, Bao H, Jones P, Varosy P, Masoudi F, Stein K, Saxon L, Curtis J. VARIATIONS IN USE OF REMOTE MONITORING OF IMPLANTABLE DEFIBRILLATORS RELATIVE TO THE INTRODUCTION OF BILLING CODES SPECIFIC TO REMOTE MONITORING. Journal Of The American College Of Cardiology 2015, 65: a459. DOI: 10.1016/s0735-1097(15)60459-4.
- Haines DE, Beheiry S, Akar JG, Baker JL, Beinborn D, Beshai JF, Brysiewicz N, Chiu-Man C, Collins KK, Dare M, Fetterly K, Fisher JD, Hongo R, Irefin S, Lopez J, Miller JM, Perry JC, Slotwiner DJ, Tomassoni GF, Weiss E. Heart Rhythm Society Expert Consensus Statement on Electrophysiology Laboratory Standards: Process, Protocols, Equipment, Personnel, and Safety. Heart Rhythm 2014, 11: e9-e51. PMID: 24814989, PMCID: PMC7106221, DOI: 10.1016/j.hrthm.2014.03.042.
- Brysiewicz N, Mitiku T, Haleem K, Bhatt P, Al-Shaaraoui M, Clancy JF, Marieb MA, Sugeng L, Akar JG. 3D Real-Time Intracardiac Echocardiographic Visualization of Atrial Structures Relevant to Atrial Fibrillation Ablation. JACC Cardiovascular Imaging 2014, 7: 97-100. PMID: 24433712, DOI: 10.1016/j.jcmg.2013.09.018.
- Akar JG, Bao H, Jones P, Wang Y, Chaudhry SI, Varosy P, Masoudi FA, Stein K, Saxon LA, Curtis JP. Use of Remote Monitoring of Newly Implanted Cardioverter-Defibrillators. Circulation 2013, 128: 2372-2383. PMID: 24043302, DOI: 10.1161/circulationaha.113.002481.
- Mukherjee R, Akar JG, Wharton JM, Adams DK, McClure CD, Stroud RE, Rice AD, DeSantis SM, Spinale FG, Gold MR. Plasma Profiles of Matrix Metalloproteinases and Tissue Inhibitors of the Metalloproteinases Predict Recurrence of Atrial Fibrillation Following Cardioversion. Journal Of Cardiovascular Translational Research 2013, 6: 528-535. PMID: 23722357, DOI: 10.1007/s12265-013-9471-2.
- RUISI CP, BRYSIEWICZ N, ASNES JD, SUGENG L, MARIEB M, CLANCY J, AKAR JG. Use of Intracardiac Echocardiography during Atrial Fibrillation Ablation. Pacing And Clinical Electrophysiology 2013, 36: 781-788. PMID: 23305194, DOI: 10.1111/pace.12030.
- Al Chekakie MO, Akar JG. Epicardial Fat and Atrial Fibrillation: A Review. Journal Of Atrial Fibrillation 2012, 4: 483. PMID: 28496734, PMCID: PMC5153200, DOI: 10.4022/jafib.483.
- Calkins H, Hindricks G, Cappato R, Kim Y, Saad E, Aguinaga L, Akar J, Badhwar V, Brugada J, Camm J, Chen P, Chen S, Chung M, Nielsen J, Curtis A, Davies D, Day J, d’Avila A, de Groot N, Di Biase L, Duytschaever M, Edgerton J, Ellenbogen K, Ellinor P, Ernst S, Fenelon G, Gerstenfeld E, Haines D, Haissaguerre M, Helm R, Hylek E, Jackman W, Jalife J, Kalman J, Kautzner J, Kottkamp H, Kuck K, Kumagai K, Lee R, Lewalter T, Lindsay B, Macle L, Mansour M, Marchlinski F, Michaud G, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds M, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao H, Verma A, Wilber D, Yamane T. 2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Patient Selection, Procedural Techniques, Patient Management and Follow-up, Definitions, Endpoints, and Research Trial Design. Heart Rhythm 2012, 9: 632-696.e21. PMID: 22386883, PMCID: PMC5846182, DOI: 10.1016/j.hrthm.2011.12.016.
- Lin B, Akar J, Mukherjee R, Purushothaman K, Eckhouse S, Liu C, Papademetris X, Dione D, Spinale F, Sinusas A. Abstract 8449: Evaluation of Atrial Remodeling and Fibrillation Vulnerability Using Molecular Imaging of Matrix Metalloproteinases. Circulation 2011, 124 DOI: 10.1161/circ.124.suppl_21.a8449.
- CLANCY JF, AKAR JG. Caveat Emptor: Implantable Devices in End‐Stage Renal Disease. Journal Of Cardiovascular Electrophysiology 2011, 22: 1105-1106. PMID: 21848637, DOI: 10.1111/j.1540-8167.2011.02094.x.
- WEBBER C, HU Z, AKAR J. UNSTABLE CARDIAC SINGULARITIES MAY LEAD TO ATRIAL FIBRILLATION. International Journal Of Bifurcation And Chaos 2011, 21: 1141-1151. DOI: 10.1142/s0218127411028994.
- Chekakie M, Akar J. Reply. Journal Of The American College Of Cardiology 2011, 57: 1249. DOI: 10.1016/j.jacc.2010.10.032.
- AKAR JG. Response to Cardiac Resynchronization in Heart Failure: Just Go With the Myocardial Blood Flow? Journal Of Cardiovascular Electrophysiology 2010, 21: 1240-1241. PMID: 20662980, DOI: 10.1111/j.1540-8167.2010.01840.x.
- Chekakie M, Welles CC, Metoyer R, Ibrahim A, Shapira AR, Cytron J, Santucci P, Wilber DJ, Akar JG. Pericardial Fat Is Independently Associated With Human Atrial Fibrillation. Journal Of The American College Of Cardiology 2010, 56: 784-788. PMID: 20797492, DOI: 10.1016/j.jacc.2010.03.071.
- Martin J, Kartje W, Goldspink P, Akar J, Paul C, Sarkey J. Induction of Nogo‐A in Cardiomyopathy. The FASEB Journal 2010, 24: lb563-lb563. DOI: 10.1096/fasebj.24.1_supplement.lb563.
- Ip J, Waldo AL, Lip GY, Rothwell PM, Martin DT, Bersohn MM, Choucair WK, Akar JG, Wathen MS, Rohani P, Halperin JL, Investigators F. Multicenter randomized study of anticoagulation guided by remote rhythm monitoring in patients with implantable cardioverter-defibrillator and CRT-D devices: Rationale, design, and clinical characteristics of the initially enrolled cohort The IMPACT study. American Heart Journal 2009, 158: 364-370.e1. PMID: 19699858, DOI: 10.1016/j.ahj.2009.07.002.
- Santucci PA, Varma N, Cytron J, Akar JG, Wilber DJ, Chekakie M, Brysiewicz N. Electroanatomic mapping of postpacing intervals clarifies the complete active circuit and variants in atrial flutter. Heart Rhythm 2009, 6: 1586-1595. PMID: 19879536, DOI: 10.1016/j.hrthm.2009.08.010.
- VASAIWALA SC, FINN C, DELPRIORE J, LEYA F, GAGERMEIER J, AKAR JG, SANTUCCI P, DAJANI K, BOVA D, PICKEN MM, BASSO C, MARCUS F, WILBER DJ. Prospective Study of Cardiac Sarcoid Mimicking Arrhythmogenic Right Ventricular Dysplasia. Journal Of Cardiovascular Electrophysiology 2009, 20: 473-476. PMID: 19017339, DOI: 10.1111/j.1540-8167.2008.01351.x.
- AKAR JG, SINGH M, AUSEON AJ, WILBER DJ. Newly Diagnosed Arrhythmogenic Right Ventricular Dysplasia in an Octogenarian. Journal Of Cardiovascular Electrophysiology 2008, 19: 1316-1318. PMID: 18631265, DOI: 10.1111/j.1540-8167.2008.01241.x.
- Akar JG, Al-Chekakie MO, Fugate T, Moran L, Froloshki B, Varma N, Santucci P, Wilber DJ, Matsumura ME. Endothelial dysfunction in heart failure identifies responders to cardiac resynchronization therapy. Heart Rhythm 2008, 5: 1229-1235. PMID: 18774094, DOI: 10.1016/j.hrthm.2008.05.027.
- PORTER M, SPEAR W, AKAR JG, HELMS R, BRYSIEWICZ N, SANTUCCI P, WILBER DJ. Prospective Study of Atrial Fibrillation Termination During Ablation Guided by Automated Detection of Fractionated Electrograms. Journal Of Cardiovascular Electrophysiology 2008, 19: 613-620. PMID: 18462320, DOI: 10.1111/j.1540-8167.2008.01189.x.
- Akar JG, Jeske W, Wilber DJ. Acute Onset Human Atrial Fibrillation Is Associated With Local Cardiac Platelet Activation and Endothelial Dysfunction. Journal Of The American College Of Cardiology 2008, 51: 1790-1793. PMID: 18452786, DOI: 10.1016/j.jacc.2007.11.083.
- Wilber D, Akar J, Santucci P, Brysiewicz N. Electrogram‐Guided Approach to Ablation of Atrial Fibrillation. 2008, 240-255. DOI: 10.1002/9781444300185.ch18.
- Akar JG, Akar FG. Regulation of ion channels and arrhythmias in the ischemic heart. Journal Of Electrocardiology 2007, 40: s37-s41. PMID: 17993326, DOI: 10.1016/j.jelectrocard.2007.05.020.
- Joyal D, Leya F, Al-Chekakie M, Arab D, Dieter RS, Morshedi-Meibodi A, Lewis B, Steen L, Fareed J, Hoppenstead D, Akar JG. Presence of asymmetric dimethylarginine gradients across high-grade lesions in patients with coronary artery disease. Coronary Artery Disease 2007, 18: 471-475. PMID: 17700219, DOI: 10.1097/mca.0b013e32818be79c.
- Chekakie M, Thompson D, Wang F, Ganguly J, Chawla R, Akar J, Barron J. Do Electrocardiographic Changes during Dobutamine Stress Echocardiography Help Detect Coronary Allograft Vasculopathy in Heart Transplant Recipients? Journal Of Cardiac Failure 2007, 13: s117-s118. DOI: 10.1016/j.cardfail.2007.06.459.
- CHEKAKIE M, AKAR JG, WANG F, MURADI H, WU J, SANTUCCI P, VARMA N, WILBER DJ. The Effects of Statins and Renin‐Angiotensin System Blockers on Atrial Fibrillation Recurrence Following Antral Pulmonary Vein Isolation. Journal Of Cardiovascular Electrophysiology 2007, 18: 942-946. PMID: 17593228, DOI: 10.1111/j.1540-8167.2007.00887.x.
- AKAR JG, AL‐CHEKAKIE M, HAI A, BRYSIEWICZ N, PORTER M, VARMA N, SANTUCCI P, WILBER DJ. Surface Electrocardiographic Patterns and Electrophysiologic Characteristics of Atrial Flutter Following Modified Radiofrequency MAZE Procedures. Journal Of Cardiovascular Electrophysiology 2007, 18: 349-355. PMID: 17394449, DOI: 10.1111/j.1540-8167.2007.00761.x.
- Akar JG, Akar FG. Mapping arrhythmias in the failing heart: from Langendorff to patient. Journal Of Electrocardiology 2006, 39: s19-s23. PMID: 16920143, DOI: 10.1016/j.jelectrocard.2006.03.011.
- Akar JG. Predicting elevated defibrillation energy requirements in heart failure with reasonable probability. Heart Rhythm 2006, 3: 1017-1018. PMID: 16945793, DOI: 10.1016/j.hrthm.2006.06.015.
- Brysiewicz N, Akar J, Santucci P, Varma N, Helms R, Mark M, Saba M, Porter M, Wilber D. P6-84 Landmark registration versus surface registration of CT with real time map using CARTO-Merge in atrial fibrillation. Heart Rhythm 2006, 3: s329. DOI: 10.1016/j.hrthm.2006.02.985.
- Oza S, Porter M, Akar J, Santucci P, Varma N, Lu Y, Wilber D. P4-60 Electroanatomical substrate of ischemic cardiomyopathy with and without spontaneous ventricular tachycardia. Heart Rhythm 2006, 3: s238. DOI: 10.1016/j.hrthm.2006.02.715.
- Hoppensteadt D, Klein A, Iqbal O, Cunanan J, Wahi R, Wilber D, Akar J, Fareed J. AB3-4 Pathogenesis of atrial fibrillation and hypercoagulability: Potential role of inflammatory response. Heart Rhythm 2006, 3: s6. DOI: 10.1016/j.hrthm.2006.02.037.
- Hoppensteadt D, Klein A, Iqbal O, Cunanan J, Wahi R, Wilber D, Fareed J, Akar J. AB3-1 Human atrial fibrillation is associated with endothelial dysfunction and oxidative stress. Heart Rhythm 2006, 3: s5. DOI: 10.1016/j.hrthm.2006.02.034.
- Daniels DV, Lu YY, Morton JB, Santucci PA, Akar JG, Green A, Wilber DJ. Idiopathic Epicardial Left Ventricular Tachycardia Originating Remote From the Sinus of Valsalva. Circulation 2006, 113: 1659-1666. PMID: 16567566, DOI: 10.1161/circulationaha.105.611640.
- Wilber D, Lipman E, Madsen H, Lin A, Santucci P, Akar J, Anderson K, Dasari R, Joshi S, Gauri A. 8. Different Mapping Systems and Approaches for Ablation of Atrial Fibrillation. EP Europace 2005, 7: s14-s14. DOI: 10.1016/j.eupc.2005.08.054.
- Patel R, DiMarco J, Akar J, Voros S, Kramer C. Chagas Myocarditis and Syncope. Journal Of Cardiovascular Magnetic Resonance 2005, 7: 685-688. DOI: 10.1081/jcmr-200065627.
- Santucci P, Joshi S, Lin A, Akar J, Tierney S, Dasari R, Gauri A, Lipman E, Wilber D. Rapid assessment of isthmus block in patients with atrial flutter. Heart Rhythm 2005, 2: s277. DOI: 10.1016/j.hrthm.2005.02.872.
- Lipman E, Madsen N, Lin A, Santucci P, Akar J, Anderson K, Dasari R, Joshi S, Gauri A, Wilber D. Incidence and determinants of left atrial scar in patients with paroxysmal and persistent atrial fibrillation undergoing catheter ablation. Heart Rhythm 2005, 2: s12. DOI: 10.1016/j.hrthm.2005.02.048.
- Lin A, Morton J, Joshi S, Dasari R, Gauri A, Lipman E, Santucci P, Akar J, Wilber D. Safety and efficacy of catheter ablation of repetitive monomorphic ventricular tachycardia arising from the sinus of Valsalva guided by intracardiac echocardiography. Heart Rhythm 2005, 2: s36. DOI: 10.1016/j.hrthm.2005.02.123.
- Patel RA, DiMarco JP, Akar JG, Voros S, Kramer CM. Chagas myocarditis and syncope. Journal Of Cardiovascular Magnetic Resonance 2005, 7: 685-8. PMID: 16136859, DOI: 10.1081/jcmr-65627.
- AKAR J, WILBER D. Amiodarone and the Excitable Gap:. Journal Of Cardiovascular Electrophysiology 2004, 15: 1424-1425. PMID: 15610290, DOI: 10.1046/j.1540-8167.2004.04679.x.
- Akar JG, Everett TH, Ho R, Craft J, Haines DE, Somlyo AP, Somlyo AV. Intracellular Chloride Accumulation and Subcellular Elemental Distribution During Atrial Fibrillation. Circulation 2003, 107: 1810-1815. PMID: 12665494, DOI: 10.1161/01.cir.0000058462.23347.93.
- KOK LC, EVERETT TH, AKAR JG, HAINES DE. Effect of Heating on Pulmonary Veins:. Journal Of Cardiovascular Electrophysiology 2003, 14: 250-254. PMID: 12716105, DOI: 10.1046/j.1540-8167.2003.02490.x.
- Mell J, Jordan D, Xiao Y, Zheng Y, Akar J, Haines D. Wavelet Analysis of Atrial Fibrillation Electrograms. 2003, 2: ii - 357-ii - 360. DOI: 10.1109/icassp.2003.1202369.
- Xiao Y, Zheng Y, Jordan D, Akar J, Haines D. Parameter Estimation of Spiral Waves from Atrial Electrograms. 2003, 5: v - 245-v - 248. DOI: 10.1109/icassp.2003.1199914.
- Everett TH, Akar JG, Kok LC, Moorman JR, Haines DE. Use of global atrial fibrillation organization to optimize the success of burst pace termination. Journal Of The American College Of Cardiology 2002, 40: 1831-1840. PMID: 12446068, DOI: 10.1016/s0735-1097(02)02476-2.
- AKAR JG, EVERETT TH, KOK L, MOORMAN JR, HAINES DE. Effect of Electrical and Structural Remodeling on Spatiotemporal Organization in Acute and Persistent Atrial Fibrillation. Journal Of Cardiovascular Electrophysiology 2002, 13: 1027-1034. PMID: 12435191, DOI: 10.1046/j.1540-8167.2002.01027.x.
- AKAR J, DIMARCO J. Tachycardia with Atrioventricular Dissociation after Surgery for Single Ventricle. Journal Of Cardiovascular Electrophysiology 2001, 12: 1092-1093. PMID: 11573704, DOI: 10.1046/j.1540-8167.2001.01092.x.
- Akar J, Kok L, Haines D, DiMarco J, Mounsey J. Coexistence of type I atrial flutter and intra-atrial re-entrant tachycardia in patients with surgically corrected congenital heart disease. Journal Of The American College Of Cardiology 2001, 38: 377-384. PMID: 11499727, DOI: 10.1016/s0735-1097(01)01392-4.
- Everett T, Moorman J, Kok L, Akar J, Haines D. Assessment of Global Atrial Fibrillation Organization to Optimize Timing of Atrial Defibrillation. Circulation 2001, 103: 2857-2861. PMID: 11401945, DOI: 10.1161/01.cir.103.23.2857.
- Yale Cardiac ElectrophysiologyYale Physicians Building800 Howard Avenue, Fl 2New Haven, CT 06519
- Yale CardiologyYale New Haven Hospital20 York StreetNew Haven, CT 06510
- Yale Heart & Vascular Center500 West Putnam AvenueGreenwich, CT 06830
- Yale Cardiac ElectrophysiologyYale Physicians Building800 Howard Avenue, Fl 2New Haven, CT 06519
- Yale CardiologyYale New Haven Hospital20 York StreetNew Haven, CT 06510
- Yale Heart & Vascular Center500 West Putnam AvenueGreenwich, CT 06830