- Yale Digestive DiseasesTemple Medical Center40 Temple Street, Ste Suite 1ANew Haven, CT 06510
- Yale Digestive DiseasesYale New Haven Hospital20 York StreetNew Haven, CT 06510
James Lorenzen Boyer, MD, FACEP
Biography
James L. Boyer, MD, specializes in liver diseases, a field he decided to pursue during a stint with the U.S. Health Service in Calcutta, India, during his medical residency. He views each case as unique and approaches each patient with flexibility. “It is important to emphasize that each patient's condition is different and not necessarily as described classically in a textbook or online, and that there is a great deal that we can do to help,” he says.
A professor of medicine (digestive diseases) at Yale School of Medicine, Dr. Boyer is also emeritus director of the Yale Liver Center, which he founded, and he has worked to improve care on a national level serving such organizations as the American Liver Foundation.
Dr. Boyer focuses his clinical practice on autoimmune and cholestatic liver diseases, which can lead to cirrhosis, and is optimistic about recent advances in the understanding of these ailments. “There are many new treatments in development that look promising,” he says. His most memorable patient was the first patient he recommended for a liver transplant. She was a young woman with cirrhosis who doctors predicted would die in several years. Under Dr. Boyer’s care, she lived another 46 years.
Titles
- Ensign Professor of Medicine (Digestive Diseases)
- Emeritus Director, Yale Liver Center
Education & Training
- FellowYale School of Medicine (1969)
- ResidentYale - New Haven Hospital (1967)
- ResidentNew York Hospital (1964)
- MDJohns Hopkins University (1962)
- ABHaverford College, Biology (1958)
Additional Information
- Emeritus Director, Yale Liver Center: (2020)
- International Recognition Award: European Association for the Study of Liver Disease (2019)
- Johns Hopkins Society of Scholars -2016: Johns Hopkins University (2016)
- Spinoza Profesesorship: University of Amsterdam, the Netherlands (2009)
- NIH MERIT Award: National Institutes of Health (2008)
- Distinguished Scientific Achievement Award: American Liver foundation (1999)
- Distinguished Achievement Award: American Association for the Study of the Liver (1998)
- Ismar-Boas Medal: German Society of Gastroenterology and Metabolism (1996)
- Ensign Professorship: Yale University (1996)
- Distinguished Achievement Award: American Gastroenterology Association (1989)
- AB of Internal Medicine, Internal Medicine (1969)
- Haverford College (2009 - Present): Board Member
- Mt Desert Island Biological Laboratory (1995 - 2013): Board Member
- American Liver Foundation (1976 - Present): voluntary health agency
- Yale University School of Medicine: Committee Member
- Du Y, de Jong I, Gupta K, Waisbourd-Zinman O, Har-Zahav A, Soroka C, Boyer J, Llewellyn J, Liu C, Naji A, Polacheck W, Wells R. Human vascularized bile duct-on-a chip: a multi-cellular micro-physiological system for studying cholestatic liver disease. Biofabrication 2023, 16: 015004. PMID: 37820623, PMCID: PMC10587873, DOI: 10.1088/1758-5090/ad0261.
- Boyer J. Bile Acid Induced Inflammation and the Role of β-Catenin. Cellular And Molecular Gastroenterology And Hepatology 2023, 16: 1033. PMID: 37690462, PMCID: PMC10685134, DOI: 10.1016/j.jcmgh.2023.08.009.
- Pan Q, Zhu G, Xu Z, Zhu J, Ouyang J, Tong Y, Zhao N, Zhang X, Cheng Y, Zhang L, Tan Y, Li J, Zhang C, Chen W, Cai S, Boyer J, Chai J. Organic Anion Transporting Polypeptide (OATP) 1B3 is a Significant Transporter for Hepatic Uptake of Conjugated Bile Acids in Humans. Cellular And Molecular Gastroenterology And Hepatology 2023, 16: 223-242. PMID: 37146714, PMCID: PMC10394288, DOI: 10.1016/j.jcmgh.2023.04.007.
- Li X, Li Y, Xiao J, Wang H, Guo Y, Mao X, Shi P, Hou Y, Zhang X, Zhao N, Zheng M, He Y, Ding J, Tan Y, Liao M, Li L, Peng Y, Li X, Pan Q, Xie Q, Li Q, Li J, Li Y, Chen Z, Huang Y, Assis DN, Cai SY, Boyer JL, Huang X, Tang CE, Liu X, Peng S, Chai J. Unique DUOX2(+)ACE2(+) small cholangiocytes are pathogenic targets for primary biliary cholangitis. Nat Commun 2023, 14: 29. PMID: 36759512, DOI: 10.1038/s41467-022-34606-w.
- Zhang L, Pan Q, Zhang L, Xia H, Liao J, Zhang X, Zhao N, Xie Q, Liao M, Tan Y, Li Q, Zhu J, Li L, Fan S, Li J, Zhang C, Cai S, Boyer J, Chai J. Runt-related transcription factor-1 ameliorates bile acid–induced hepatic inflammation in cholestasis through JAK/STAT3 signaling. Hepatology 2023, 77: 1866-1881. PMID: 36647589, PMCID: PMC10921919, DOI: 10.1097/hep.0000000000000041.
- Gallucci GM, Trottier J, Hemme C, Assis DN, Boyer JL, Barbier O, Ghonem NS. Adjunct Fenofibrate Up‐regulates Bile Acid Glucuronidation and Improves Treatment Response For Patients With Cholestasis. Hepatology Communications 2021, 5: 2035-2051. PMID: 34558841, PMCID: PMC8631103, DOI: 10.1002/hep4.1787.
- Stieger B, Boyer JL. In Memoriam: Peter J. Meier (1947–2021). Journal Of Hepatology 2021, 75: 761-762. DOI: 10.1016/j.jhep.2021.06.039.
- Efe C, Dhanasekaran R, Lammert C, Ebik B, la Tijera F, Aloman C, Calışkan A, Peralta M, Gerussi A, Massoumi H, Catana AM, Torgutalp M, Purnak T, Rigamonti C, Aldana A, Khakoo N, Kacmaz H, Nazal L, Frager S, Demir N, Irak K, Ellik ZM, Balaban Y, Atay K, Eren F, Cristoferi L, Batıbay E, Urzua Á, Snijders R, Kıyıcı M, Akyıldız M, Ekin N, Carr RM, Harputluoğlu M, Hatemi I, Mendizabal M, Silva M, Idilman R, Silveira M, Drenth JPH, Assis DN, Björnsson E, Boyer JL, Invernizzi P, Levy C, Schiano TD, Ridruejo E, Wahlin S. Outcome of COVID‐19 in Patients With Autoimmune Hepatitis: An International Multicenter Study. Hepatology 2021, 73: 2099-2109. PMID: 33713486, PMCID: PMC8250536, DOI: 10.1002/hep.31797.
- Soroka CJ, Roberts SJ, Boyer JL, Assis DN. Role of Biliary Organoids in Cholestasis Research and Regenerative Medicine. Seminars In Liver Disease 2021, 41: 206-212. PMID: 33957696, DOI: 10.1055/s-0041-1728663.
- Cai SY, Boyer JL. The role of bile acids in cholestatic liver injury. Annals Of Translational Medicine 2021, 9: 737-737. PMID: 33987435, PMCID: PMC8106037, DOI: 10.21037/atm-20-5110.
- Boyer JL, Soroka CJ. Bile formation and secretion: An update. Journal Of Hepatology 2021, 75: 190-201. PMID: 33617926, DOI: 10.1016/j.jhep.2021.02.011.
- Li B, Cai SY, Boyer JL. The role of the retinoid receptor, RAR/RXR heterodimer, in liver physiology. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease 2021, 1867: 166085. PMID: 33497820, DOI: 10.1016/j.bbadis.2021.166085.
- Cai SY, Yu D, Soroka CJ, Wang J, Boyer JL. Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis. Journal Of Hepatology 2020, 74: 550-559. PMID: 33039404, PMCID: PMC7897288, DOI: 10.1016/j.jhep.2020.09.035.
- Soroka C, Roberts S, Hohenester S, Boyer J, Assis D. AS055 Co-culture of bile-derived organoids from primary sclerosing cholangitis patients with CD4+ T cells replicates pathogenic, CCL20 dependent biliary-immune interactions. Journal Of Hepatology 2020, 73: s41. DOI: 10.1016/s0168-8278(20)30634-6.
- Ghonem NS, Auclair AM, Hemme CL, Gallucci GM, de la Rosa Rodriguez R, Boyer JL, Assis DN. Fenofibrate Improves Liver Function and Reduces the Toxicity of the Bile Acid Pool in Patients With Primary Biliary Cholangitis and Primary Sclerosing Cholangitis Who Are Partial Responders to Ursodiol. Clinical Pharmacology & Therapeutics 2020, 108: 1213-1223. PMID: 32480421, PMCID: PMC7886378, DOI: 10.1002/cpt.1930.
- Gao E, Cheema H, Waheed N, Mushtaq I, Erden N, Nelson‐Williams C, Jain D, Soroka CJ, Boyer JL, Khalil Y, Clayton PT, Mistry PK, Lifton RP, Vilarinho S. Organic Solute Transporter Alpha Deficiency: A Disorder With Cholestasis, Liver Fibrosis, and Congenital Diarrhea. Hepatology 2020, 71: 1879-1882. PMID: 31863603, PMCID: PMC8577800, DOI: 10.1002/hep.31087.
- Gigliozzi A, Fraioli F, Boyer J. Hormonal Regulation of Cholangiocyte Secretion. 2020, 89-95. DOI: 10.1201/9780367813888-8.
- Boyer J. Adaptive Regulation of Hepatocyte Transporters in Cholestasis. 2020, 378-389. DOI: 10.1002/9781119436812.ch31.
- Cai S, Li M, Boyer J. The Role of Bile Acid‐Mediated Inflammation in Cholestatic Liver Injury. 2020, 728-736. DOI: 10.1002/9781119436812.ch56.
- Lindor K, Bowlus C, Boyer J, Levy C, Mayo M. Primary Biliary Cholangitis: 2018 Practice Guidance From the American Association for the Study of Liver Diseases. Clinical Liver Disease 2020, 15: 1-2. PMCID: PMC7041951, DOI: 10.1002/cld.874.
- Cai SY, Ge M, Mennone A, Hoque R, Ouyang X, Boyer JL. Inflammasome Is Activated in the Liver of Cholestatic Patients and Aggravates Hepatic Injury in Bile Duct–Ligated Mouse. Cellular And Molecular Gastroenterology And Hepatology 2019, 9: 679-688. PMID: 31887435, PMCID: PMC7160576, DOI: 10.1016/j.jcmgh.2019.12.008.
- Soroka CJ, Assis DN, Alrabadi LS, Roberts S, Cusack L, Jaffe AB, Boyer JL. Bile‐Derived Organoids From Patients With Primary Sclerosing Cholangitis Recapitulate Their Inflammatory Immune Profile. Hepatology 2019, 70: 871-882. PMID: 30561836, DOI: 10.1002/hep.30470.
- Soroka CJ, Assis DN, Boyer JL. Patient-Derived Organoids from Human Bile: An In Vitro Method to Study Cholangiopathies. 2019, 1981: 363-372. PMID: 31016667, DOI: 10.1007/978-1-4939-9420-5_24.
- Cai S, Boyer JL. Bile Infarcts: New Insights Into the Pathogenesis of Obstructive Cholestasis. Hepatology 2019, 69: 473-475. PMID: 30251326, DOI: 10.1002/hep.30291.
- Lindor KD, Bowlus CL, Boyer J, Levy C, Mayo M. Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases. Hepatology 2019, 69: 394-419. PMID: 30070375, DOI: 10.1002/hep.30145.
- Pan Q, Zhang X, Zhang L, Cheng Y, Zhao N, Li F, Zhou X, Chen S, Li J, Xu S, Huang D, Chen Y, Li L, Wang H, Chen W, Cai SY, Boyer JL, Chai J. Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis. Gastroenterology 2018, 155: 1578-1592.e16. PMID: 30063921, PMCID: PMC6221191, DOI: 10.1053/j.gastro.2018.07.031.
- Yu D, Cai S, Mennone A, Vig P, Boyer JL. Cenicriviroc, a cytokine receptor antagonist, potentiates all‐trans retinoic acid in reducing liver injury in cholestatic rodents. Liver International 2018, 38: 1128-1138. PMID: 29356312, PMCID: PMC6032984, DOI: 10.1111/liv.13698.
- Boyer JL. OSTα-OSTβ Guards the Ileal Enterocyte From the Accumulation of Toxic Levels of Bile Acids. Cellular And Molecular Gastroenterology And Hepatology 2018, 5: 649-650. PMID: 29713669, PMCID: PMC5924743, DOI: 10.1016/j.jcmgh.2018.01.015.
- Goldberg DS, Levy C, Yimam K, Gordon SC, Forman L, Verna E, Yu L, Rahimi R, Schwarz K, Eksteen B, Pratt D, Boyer JL, Assis D, Bowlus C. Primary Sclerosing Cholangitis Is Not Rare Among Blacks in a Multicenter North American Consortium. Clinical Gastroenterology And Hepatology 2017, 16: 591-593. PMID: 29102704, PMCID: PMC5860952, DOI: 10.1016/j.cgh.2017.10.028.
- Li M, Cai SY, Boyer JL. Mechanisms of bile acid mediated inflammation in the liver. Molecular Aspects Of Medicine 2017, 56: 45-53. PMID: 28606651, PMCID: PMC5662014, DOI: 10.1016/j.mam.2017.06.001.
- Boyer JL. Maintaining a Vibrant and Productive Laboratory as a Senior Investigator. Cellular And Molecular Gastroenterology And Hepatology 2017, 4: 299-300. PMID: 28840184, PMCID: PMC5560913, DOI: 10.1016/j.jcmgh.2017.04.008.
- Cai SY, Ouyang X, Chen Y, Soroka CJ, Wang J, Mennone A, Wang Y, Mehal WZ, Jain D, Boyer JL. Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response. JCI Insight 2017, 2: e90780. PMID: 28289714, PMCID: PMC5333973, DOI: 10.1172/jci.insight.90780.
- Assis DN, Abdelghany O, Cai SY, Gossard AA, Eaton JE, Keach JC, Deng Y, Setchell KD, Ciarleglio M, Lindor KD, Boyer JL. Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis. Journal Of Clinical Gastroenterology 2017, 51: e11-e16. PMID: 27428727, PMCID: PMC5218875, DOI: 10.1097/mcg.0000000000000591.
- Roberts S, Leng L, Soroka C, Boyer J, Bucala R, Assis D. FRI-393 Macrophage migration inhibitory factor (MIF) modulates T-cell proliferation and hepatic inflammation in a model of autoimmune liver disease. Journal Of Hepatology 2017, 66: s363-s364. DOI: 10.1016/s0168-8278(17)31067-x.
- Cai SY, Boyer JL. Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury. Inflammation And Cell Signaling 2017, 4 PMID: 28804737, PMCID: PMC5553904, DOI: 10.14800/ics.1561.
- Kulkarni SR, Soroka CJ, Hagey LR, Boyer JL. Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid–fed mouse model of cholestasis. Hepatology 2016, 64: 2151-2164. PMID: 27639250, PMCID: PMC5115990, DOI: 10.1002/hep.28826.
- Li M, Soroka CJ, Harry K, Boyer JL. CFTR-associated ligand is a negative regulator of Mrp2 expression. American Journal Of Physiology - Cell Physiology 2016, 312: c40-c46. PMID: 27834195, PMCID: PMC5283898, DOI: 10.1152/ajpcell.00100.2016.
- Xu S, Soroka CJ, Sun AQ, Backos DS, Mennone A, Suchy FJ, Boyer JL. A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization. PLOS ONE 2016, 11: e0158269. PMID: 27351185, PMCID: PMC4924846, DOI: 10.1371/journal.pone.0158269.
- Li M, Mennone A, Soroka CJ, Hagey LR, Ouyang X, Weinman EJ, Boyer JL. Na+/H+ exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury. Hepatology 2015, 62: 1227-1236. PMID: 26108984, PMCID: PMC4589453, DOI: 10.1002/hep.27956.
- Ghonem NS, Assis DN, Boyer JL. Fibrates and cholestasis. Hepatology 2015, 62: 635-643. PMID: 25678132, PMCID: PMC4515188, DOI: 10.1002/hep.27744.
- Chai J, Cai SY, Liu X, Lian W, Chen S, Zhang L, Feng X, Cheng Y, He X, He Y, Chen L, Wang R, Wang H, Boyer JL, Chen W. Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis. Journal Of Hepatology 2015, 63: 1440-1448. PMID: 26212029, PMCID: PMC4686151, DOI: 10.1016/j.jhep.2015.07.016.
- Boyer JL. The origins of hepatobiliary and gastrointestinal physiology. Hepatology 2015, 61: 1452-1454. PMID: 25677183, PMCID: PMC4447183, DOI: 10.1002/hep.27737.
- Assis DN, Leng L, Du X, Zhang CK, Grieb G, Merk M, Garcia AB, McCrann C, Chapiro J, Meinhardt A, Mizue Y, Nikolic‐Paterson D, Bernhagen J, Kaplan MM, Zhao H, Boyer JL, Bucala R. The role of macrophage migration inhibitory factor in autoimmune liver disease. Hepatology 2013, 59: 580-591. PMID: 23913513, PMCID: PMC3877200, DOI: 10.1002/hep.26664.
- Boyer JL. Bile Formation and Secretion. 2013, 3: 1035-1078. PMID: 23897680, PMCID: PMC4091928, DOI: 10.1002/cphy.c120027.
- Plotkin E, Assis D, Boyer J. Now you see it, now you don't. Hepatology 2013, 58: 446-447. DOI: 10.1002/hep.26439.
- Cai S, Lionarons DA, Hagey L, Soroka CJ, Mennone A, Boyer JL. Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion. Hepatology 2013, 57: 2418-2426. PMID: 23175353, PMCID: PMC3604052, DOI: 10.1002/hep.26161.
- Soroka CJ, Boyer JL. Biosynthesis and trafficking of the bile salt export pump, BSEP: Therapeutic implications of BSEP mutations. Molecular Aspects Of Medicine 2013, 37: 3-14. PMID: 23685087, PMCID: PMC3784619, DOI: 10.1016/j.mam.2013.05.001.
- Lam P, Xu S, Soroka CJ, Boyer JL. A C‐terminal tyrosine‐based motif in the bile salt export pump directs clathrin‐dependent endocytosis. Hepatology 2012, 55: 1901-1911. PMID: 22161577, PMCID: PMC3319652, DOI: 10.1002/hep.25523.
- Boyer J, Garcia‐Tsao G, Groszmann R. In Memoriam: Harold O. Conn, M.D. Hepatology 2012, 55: 658-658. DOI: 10.1002/hep.25550.
- Soroka CJ, Velazquez H, Mennone A, Ballatori N, Boyer JL. Ostα depletion protects liver from oral bile acid load. AJP Gastrointestinal And Liver Physiology 2011, 301: g574-g579. PMID: 21719738, PMCID: PMC3174539, DOI: 10.1152/ajpgi.00141.2011.
- Padda MS, Sanchez M, Akhtar AJ, Boyer JL. Drug‐induced cholestasis. Hepatology 2011, 53: 1377-1387. PMID: 21480339, PMCID: PMC3089004, DOI: 10.1002/hep.24229.
- He H, Mennone A, Boyer JL, Cai S. Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct–ligated rats and human hepatic cells. Hepatology 2010, 53: 548-557. PMID: 21274875, PMCID: PMC3069505, DOI: 10.1002/hep.24047.
- Lam P, Soroka C, Boyer J. The Bile Salt Export Pump: Clinical and Experimental Aspects of Genetic and Acquired Cholestatic Liver Disease. Seminars In Liver Disease 2010, 30: 125-133. PMID: 20422495, PMCID: PMC3008346, DOI: 10.1055/s-0030-1253222.
- Boyer J. Cholestasis: Genetic and Acquired. Seminars In Liver Disease 2010, 30: 113-115. PMID: 20422493, DOI: 10.1055/s-0030-1253220.
- Azzaroli F, Mennone A, Raspanti M, Longo M, Turco L, Buonfiglioli F, Giandinoto M, Roda E, Mazzella N, Lodato F, Montagnani M, Boyer J, Mazzella G. 912 UDCA UP-REGULATES HUMAN PLACENTAL OATP-A MRNA EXPRESSION. Journal Of Hepatology 2010, 52: s354. DOI: 10.1016/s0168-8278(10)60913-0.
- Azzaroli F, Mennone A, Raspanti M, Longo M, Montagnani M, Turco L, Buonfiglioli F, Giandinoto M, Lodato F, Roda E, Lisotti A, Cecinato P, Boyer J, Mazzella G. P.237 UDCA UP-REGULATES HUMAN PLACENTAL OATP-A EXPRESSION IN INTRAHEPATIC CHOLESTASIS OF PREGNANCY. Digestive And Liver Disease 2010, 42: s185. DOI: 10.1016/s1590-8658(10)60349-0.
- Azzaroli F, Mennone A, Raspanti M, Longo M, Montagnani M, Turco L, Buonfiglioli F, Giandinoto M, Lodato F, Lisotti A, Cecinato P, Roda E, Boyer J, Mazzella G. T.N.4 UDCA UP-REGULATES HUMAN PLACENTAL OATP-A EXPRESSION IN INTRAHEPATIC CHOLESTASIS OF PREGNANCY. Digestive And Liver Disease 2010, 42: s16. DOI: 10.1016/s1590-8658(10)60409-4.
- Boyer J. Adaptive Regulation of Hepatocyte Transporters in Cholestasis. 2009, 681-702. DOI: 10.1002/9780470747919.ch43.
- Boyer JL. It's all about bile. Hepatology 2009, 49: 711-723. PMID: 19242972, DOI: 10.1002/hep.22719.
- Cai S, Gautam S, Nguyen T, Soroka C, Rahner C, Boyer J. Fic1-deficient rat hepatocytes reveal structural and functional defects in the bile canalicular membrane when exposed to hydrophobic bile acids. 2009, 18-20. DOI: 10.1007/978-1-4020-9644-0_3.
- Cai S, Gautam S, Nguyen T, Soroka CJ, Rahner C, Boyer JL. ATP8B1 Deficiency Disrupts the Bile Canalicular Membrane Bilayer Structure in Hepatocytes, But FXR Expression and Activity Are Maintained. Gastroenterology 2008, 136: 1060-1069.e4. PMID: 19027009, PMCID: PMC3439851, DOI: 10.1053/j.gastro.2008.10.025.
- Nava G, Lee D, Cai S, Boyer J, Hernández‐Zavala A, Thomas D, Gaskins H. Arsenic (+3 oxidation state) methyltransferase and the methylation of arsenicals in the invertebrate chordate Ciona intestinalis. The FASEB Journal 2008, 22: 796.1-796.1. DOI: 10.1096/fasebj.22.1_supplement.796.1.
- AZZAROLI F, MENNONE A, FELETTI V, SIMONI P, BAGLIVO E, MONTAGNANI M, RIZZO N, PELUSI G, DE ALOYSIO D, LODATO F, FESTI D, COLECCHIA A, RODA E, BOYER J, MAZZELLA G. Clinical trial: modulation of human placental multidrug resistance proteins in cholestasis of pregnancy by ursodeoxycholic acid. Alimentary Pharmacology & Therapeutics 2007, 26: 1139-1146. PMID: 17894656, DOI: 10.1111/j.1365-2036.2007.03462.x.
- Soroka C, Xu S, Cai S, Ballatori N, Boyer J. Insights into the regulation of expression of human OSTα-OSTβ. 2007, 155: 53-56. DOI: 10.1007/978-1-4020-6252-0_7.
- Meier-Abt F, Hammann-Hänni A, Stieger B, Ballatori N, Boyer J. The organic anion transport polypeptide 1d1 (Oatp1d1) mediates hepatocellular uptake of phalloidin and microcystin into skate liver. Toxicology And Applied Pharmacology 2006, 218: 274-279. PMID: 17198718, DOI: 10.1016/j.taap.2006.11.015.
- Azzaroli F, Feletti V, Mennone A, Simoni P, Maglinolo M, Baglivo E, Rizzo N, Lodato F, Festi D, Colecchia A, Roda A, Roda E, Boyer J, Mazzella G. Modulation of placental bilirubin and bile acids transporters during cholestasis of pregnancy. Digestive And Liver Disease 2006, 38: s97-s98. DOI: 10.1016/s1590-8658(06)80260-4.
- Azzaroli E, Mennone A, Feletti V, Simoni P, Magliuolo M, Baglivo E, Rizzo N, Lodato E, Festi D, Colecchia A, Roda A, Roch E, Boyer J, Mazzella G. 627 Modulation of placental bilirubin and bile acids transporters during cholestasis of pregnancy. Journal Of Hepatology 2006, 44: s233. DOI: 10.1016/s0168-8278(06)80627-6.
- Boyer J, Chen W, Cai S, Denk G, Bohan A, Soroka C, Denson L. Adaptive regulation of bile salt transporters in cholestasis. 2005, 144: 186-188. DOI: 10.1007/1-4020-2916-0_16.
- Chen W, Bohan A, Denk G, Soroka C, Denson L, Boyer J. Adaptive regulation of bile salt transporters in cholestasis — the role of MRPs. 2005, 141: 130-131. DOI: 10.1007/1-4020-2913-6_17.
- Mattingly C, Colby G, Rosenstein M, Forrest J, Boyer J. Promoting comparative molecular studies in environmental health research: an overview of the comparative toxicogenomics database (CTD). The Pharmacogenomics Journal 2004, 4: 5-8. PMID: 14735110, DOI: 10.1038/sj.tpj.6500225.
- Bohan A, Chen W, Denson L, Held M, Boyer J. 27 MRP3/MRP3(ABCC3/ABCC3) is up-regulated by TNF α via (cholesterol 7 α hydroxylase promoter factor (CPF) and is hepatoprotective in obstructive cholestasis. Hepatology 2003, 38: 168. DOI: 10.1016/s0270-9139(03)80070-8.
- Chen W, Denson L, Bohan A, Cai S, Wang L, Soroka C, Boyer J. 82 The cholesterol-7α hydroxylase promoter factor (CPF) up-regulates the human multidrug resistance-associated protein 3 (MRP3) and is induced by bile salts in HEPG2 cells. Hepatology 2003, 38: 195. DOI: 10.1016/s0270-9139(03)80125-8.
- Mattingly C, Colby G, Forrest J, Boyer J. The Comparative Toxicogenomics Database (CTD). Environmental Health Perspectives 2003 DOI: 10.1289/txg.6028.
- Soroka C, Mennone A, Boyer J. 1102 Susceptibility to estrogen induced cholestasis in the female is associated with loss of radixin, an MRP2 tethering protein, from the canalicular membrane. Hepatology 2003, 38: 687. DOI: 10.1016/s0270-9139(03)81140-0.
- Denk G, Soroka C, Mennone A, Koepsell H, Beuers U, Boyer J. 26 Obstructive cholestasis results in down-regulation and functional impairment of the organic cation transporter 1 (OCT1) in rat. Hepatology 2003, 38: 168. DOI: 10.1016/s0270-9139(03)80069-1.
- Bohan A, Boyer J. Mechanisms of Hepatic Transport of Drugs: Implications for Cholestatic Drug Reactions. Seminars In Liver Disease 2002, 22: 123-136. PMID: 12016544, DOI: 10.1055/s-2002-30099.
- Lee J, Azzaroli F, Wang L, Soroka C, Gigliozzi A, Setchell K, Kramer W, Boyer J. Adaptive regulation of bile salt transporters in kidney and liver in obstructive cholestasis in the rat. Gastroenterology 2001, 121: 1473-1484. PMID: 11729126, DOI: 10.1053/gast.2001.29608.
- Singh S, Mennone A, Gigliozzi A, Fraioli F, Boyer J. Cl−-dependent secretory mechanisms in isolated rat bile duct epithelial units. AJP Gastrointestinal And Liver Physiology 2001, 281: g438-g446. PMID: 11447024, DOI: 10.1152/ajpgi.2001.281.2.g438.
- Cai S, Wang L, Ballatori N, Boyer J. Bile salt export pump is highly conserved during vertebrate evolution and its expression is inhibited by PFIC type II mutations. AJP Gastrointestinal And Liver Physiology 2001, 281: g316-g322. PMID: 11447010, DOI: 10.1152/ajpgi.2001.281.2.g316.
- Wang W, Seward D, Li L, Boyer J, Ballatori N. Expression cloning of two genes that together mediate organic solute and steroid transport in the liver of a marine vertebrate. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 9431-9436. PMID: 11470901, PMCID: PMC55438, DOI: 10.1073/pnas.161099898.
- Trauner M, Boyer J. Cholestatic syndromes. Current Opinion In Gastroenterology 2001, 17: 242-256. PMID: 17031165, DOI: 10.1097/00001574-200105000-00007.
- Soroka C, Lee J, Azzaroli F, Boyer J. Cellular localization and up‐regulation of multidrug resistance–associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver. Hepatology 2001, 33: 783-791. PMID: 11283840, DOI: 10.1053/jhep.2001.23501.
- Boyer J. Advancing the bile‐ology of cholestatic liver disease. Hepatology 2001, 33: 758-759. PMID: 11230758, DOI: 10.1053/jhep.2001.23034.
- Cho W, Mennone A, Boyer J. Isolation of functional polarized bile duct units from mouse liver. AJP Gastrointestinal And Liver Physiology 2001, 280: g241-g246. PMID: 11208546, DOI: 10.1152/ajpgi.2001.280.2.g241.
- Mennone A, Biemesderfer D, Negoianu D, Yang C, Abbiati T, Schultheis P, Shull G, Aronson P, Boyer J. Role of sodium/hydrogen exchanger isoform NHE3 in fluid secretion and absorption in mouse and rat cholangiocytes. AJP Gastrointestinal And Liver Physiology 2001, 280: g247-g254. PMID: 11208547, DOI: 10.1152/ajpgi.2001.280.2.g247.
- Schlosser S, Azzaroli F, Dao T, Hingorani R, Crispe I, Boyer J. Induction of murine hepatocyte death by membrane‐bound CD95 (Fas/APO‐1)‐ligand: Characterization of an in Vitro system. Hepatology 2000, 32: 779-785. PMID: 11003622, DOI: 10.1053/jhep.2000.18422.
- Gigliozzi A, Fraioli F, Sundaram P, Lee J, Mennone A, Alvaro D, Boyer J. Molecular identification and functional characterization of Mdr1a in rat cholangiocytes. Gastroenterology 2000, 119: 1113-1122. PMID: 11040198, DOI: 10.1053/gast.2000.18156.
- Dranoff J, O'Neill A, Franco A, Cai S, Connolly G, Ballatori N, Boyer J, Nathanson M. A Primitive ATP Receptor from the Little Skate Raja erinacea *. Journal Of Biological Chemistry 2000, 275: 30701-30706. PMID: 10900200, DOI: 10.1074/jbc.m003366200.
- Rebbeor J, Connolly G, Henson J, Boyer J, Ballatori N. ATP-dependent GSH and glutathioneS-conjugate transport in skate liver: role of an Mrp functional homologue. AJP Gastrointestinal And Liver Physiology 2000, 279: g417-g425. PMID: 10915652, DOI: 10.1152/ajpgi.2000.279.2.g417.
- Trauner M, Boyer J. Cholestatic syndromes. Current Opinion In Gastroenterology 2000, 16: 239-250. PMID: 17023881, DOI: 10.1097/00001574-200005000-00006.
- Dranoff J, O’Neill A, Cai S, Franco A, Connelly G, Ballatori N, Boyer J, Nathanson M. Molecular identification of a primitive P2Y ATP receptor in liver from the little skate Raja erinacea. Gastroenterology 2000, 118: a911. DOI: 10.1016/s0016-5085(00)85777-7.
- Ballatori N, Rebbeor J, Connolly G, Seward D, Lenth B, Henson J, Sundaram P, Boyer J. Bile salt excretion in skate liver is mediated by a functional analog of Bsep/Spgp, the bile salt export pump. AJP Gastrointestinal And Liver Physiology 2000, 278: g57-g63. PMID: 10644562, DOI: 10.1152/ajpgi.2000.278.1.g57.
- Lee J, Trauner M, Soroka C, Stieger B, Meier P, Boyer J. Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology 2000, 118: 163-172. PMID: 10611165, DOI: 10.1016/s0016-5085(00)70425-2.
- Ballatori N, Connolly G, Boyer J. Elasmobranch hepatocytes. 2000, 37-47. DOI: 10.1007/978-94-017-3345-8_5.
- Runnegar M, Seward D, Ballatori N, Crawford J, Boyer J. Hepatic Toxicity and Persistence of ser/thr Protein Phosphatase Inhibition by Microcystin in the Little Skate Raja erinacea. Toxicology And Applied Pharmacology 1999, 161: 40-49. PMID: 10558922, DOI: 10.1006/taap.1999.8783.
- Ballatori N, Hager D, Nundy S, Miller D, Boyer J. Carrier-mediated uptake of lucifer yellow in skate and rat hepatocytes: a fluid-phase marker revisited. American Journal Of Physiology 1999, 277: g896-g904. PMID: 10516157, DOI: 10.1152/ajpgi.1999.277.4.g896.
- Soroka C, Pate M, Boyer J. Canalicular Export Pumps Traffic with Polymeric Immunoglobulin A Receptor on the Same Microtubule-associated Vesicle in Rat Liver*. Journal Of Biological Chemistry 1999, 274: 26416-26424. PMID: 10473600, DOI: 10.1074/jbc.274.37.26416.
- Combes B, Markin R, Wheeler D, Rubin R, West A, Mills A, Eigenbrodt E, Maddrey W, Munoz S, Garcia‐Tsao G, Bonner G, Boyer J, Luketic V, Shiffman M, Peters M, White H, Zetterman R, Carithers R. The effect of ursodeoxycholic acid on the florid duct lesion of primary biliary cirrhosis. Hepatology 1999, 30: 602-605. PMID: 10462363, PMCID: PMC3935822, DOI: 10.1002/hep.510300315.
- Cho W, Boyer J. Vasoactive intestinal polypeptide is a potent regulator of bile secretion from rat cholangiocytes. Gastroenterology 1999, 117: 420-428. PMID: 10419925, DOI: 10.1053/gast.1999.0029900420.
- Trauner M, Meier P, Boyer J. Molecular regulation of hepatocellular transport systems in cholestasis. Journal Of Hepatology 1999, 31: 165-178. PMID: 10424299, DOI: 10.1016/s0168-8278(99)80179-2.
- Combes B, Carithers R, Maddrey W, Munoz S, Garcia‐Tsao G, Bonner G, Boyer J, Luketic V, Shiffman M, Peters M, White H, Zetterman R, Risser R, Rossi S, Hofmann A. Biliary bile acids in primary biliary cirrhosis: Effect of ursodeoxycholic acid. Hepatology 1999, 29: 1649-1654. PMID: 10347103, PMCID: PMC4004074, DOI: 10.1002/hep.510290618.
- Cho W, Boyer J. Characterization of ion transport mechanisms involved in bombesin-stimulated biliary secretion in rat cholangiocytes. Journal Of Hepatology 1999, 30: 1045-1051. PMID: 10406182, DOI: 10.1016/s0168-8278(99)80258-x.
- Trauner M, Boyer J. Cholestatic syndromes. Current Opinion In Gastroenterology 1999, 15: 217-228. PMID: 17023948, DOI: 10.1097/00001574-199905000-00006.
- Hayes J, Soroka C, Rios‐Velez L, Boyer J. Hepatic sequestration and modulation of the canalicular transport of the organic cation, daunorubicin, in the rat. Hepatology 1999, 29: 483-493. PMID: 9918926, DOI: 10.1002/hep.510290216.
- Beuers U, Probst I, Soroka C, Boyer J, Kullak‐Ublick G, Paumgartner G. Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes. Hepatology 1999, 29: 477-482. PMID: 9918925, DOI: 10.1002/hep.510290227.
- Trauner M, Mennone A, Gigliozzi A, Fraioli F, Boyer J. Nitric oxide and guanosine 3′,5′‐cyclic monophosphate stimulate bile secretion in isolated rat hepatocyte couplets, but not in isolated bile duct units. Hepatology 1998, 28: 1621-1628. PMID: 9828227, DOI: 10.1002/hep.510280623.
- Beuers U, Boyer J, Paumgartner G. Ursodeoxycholic acid in cholestasis: Potential mechanisms of action and therapeutic applications. Hepatology 1998, 28: 1449-1453. PMID: 9828205, DOI: 10.1002/hep.510280601.
- Wolkoff A, Suchy F, Moseley R, Meier P, Gollan J, Freimer N, Fitz J, Boyer J, Berk P, Scharschmidt B. Advances in hepatic transport: Molecular mechanisms, genetic disorders, and treatment. A summary of the 1998 AASLD single topic conference. Hepatology 1998, 28: 1713-1719. PMID: 9828241, DOI: 10.1002/hep.510280637.
- Zheng T, Schlosser S, Dao T, Hingorani R, Crispe I, Boyer J, Flavell R. Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 13618-13623. PMID: 9811849, PMCID: PMC24868, DOI: 10.1073/pnas.95.23.13618.
- Cho W, Mennone A, Boyer J. Intracellular pH regulation in bombesin-stimulated secretion in isolated bile duct units from rat liver. American Journal Of Physiology 1998, 275: g1028-g1036. PMID: 9815033, DOI: 10.1152/ajpgi.1998.275.5.g1028.
- Epstein F, Trauner M, Meier P, Boyer J. Molecular Pathogenesis of Cholestasis. New England Journal Of Medicine 1998, 339: 1217-1227. PMID: 9780343, DOI: 10.1056/nejm199810223391707.
- Arrese M, Trauner M, Ananthanarayanan M, Boyer J, Suchy F. Maternal cholestasis does not affect the ontogenic pattern of expression of the Na+/Taurocholate cotransporting polypeptide (ntcp) in the fetal and neonatal rat liver. Hepatology 1998, 28: 789-795. PMID: 9731574, DOI: 10.1002/hep.510280328.
- Crawford J, Boyer J. Clinicopathology conferences: Inflammation‐induced cholestasis. Hepatology 1998, 28: 253-260. PMID: 9657120, DOI: 10.1002/hep.510280133.
- Trauner M, Arrese M, Lee H, Boyer J, Karpen S. Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors. Journal Of Clinical Investigation 1998, 101: 2092-2100. PMID: 9593765, PMCID: PMC508797, DOI: 10.1172/jci1680.
- Koeppel T, Trauner M, Albert M, Arrese M, Rios-Velez L, Boyer J. Role of glutathione in hepatic bile formation during reperfusion after cold ischemia of the rat liver. Journal Of Hepatology 1998, 28: 812-819. PMID: 9625316, DOI: 10.1016/s0168-8278(98)80231-6.
- Roelofsen H, Soroka C, Keppler D, Boyer J. Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets. Journal Of Cell Science 1998, 111: 1137-1145. PMID: 9512509, DOI: 10.1242/jcs.111.8.1137.
- Ballatori N, Boyer J. ATP regulation of a swelling‐activated osmolyte channel in skate hepatocytes. Journal Of Experimental Zoology 1997, 279: 471-475. PMID: 9392868, DOI: 10.1002/(sici)1097-010x(19971201)279:5<471::aid-jez9>3.0.co;2-l.
- Fricker G, Wössner R, Drewe J, Fricker R, Boyer J. Enterohepatic circulation of scymnol sulfate in an elasmobranch, the little skate (Raja erinacea). American Journal Of Physiology 1997, 273: g1023-g1030. PMID: 9374698, DOI: 10.1152/ajpgi.1997.273.5.g1023.
- Koeppel T, Trauner M, Baas J, Thies J, Schlosser S, Post S, Gebhard M, Herfarth C, Boyer J, Otto G. Extrahepatic biliary obstruction impairs microvascular perfusion and increases leukocyte adhesion in rat liver. Hepatology 1997, 26: 1085-1091. PMID: 9362346, DOI: 10.1002/hep.510260501.
- Trauner M, Arrese M, Soroka C, Ananthanarayanan M, Koeppel T, Schlosser S, Suchy F, Keppler D, Boyer J. The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology 1997, 113: 255-264. PMID: 9207286, DOI: 10.1016/s0016-5085(97)70103-3.
- Cho W, Mennone A, Rydberg, Boyer J. Bombesin stimulates bicarbonate secretion from rat cholangiocytes: Implications for neural regulation of bile secretion. Gastroenterology 1997, 113: 311-321. PMID: 9207292, DOI: 10.1016/s0016-5085(97)70109-4.
- Gartung C, Schuele S, Schlosser S, Boyer J. Expression of the rat liver Na+/taurocholate cotransporter is regulated in vivo by retention of biliary constituents but not their depletion. Hepatology 1997, 25: 284-290. PMID: 9021935, DOI: 10.1002/hep.510250205.
- Setchell K, Rodrigues C, Clerici C, Solinas A, Morelli A, Gartung C, Boyer J. Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei. Gastroenterology 1997, 112: 226-235. PMID: 8978363, DOI: 10.1016/s0016-5085(97)70239-7.
- Ballatori N, Boyer J. Disruption of Cell Volume Regulation by Mercuric Chloride Is Mediated by an Increase in Sodium Permeability and Inhibition of an Osmolyte Channel in Skate Hepatocytes. Toxicology And Applied Pharmacology 1996, 140: 404-410. PMID: 8887458, DOI: 10.1006/taap.1996.0237.
- Boyer J. Bile secretion-models, mechanisms, and malfunctions. A perspective on the development of modern cellular and molecular concepts of bile secretion and cholestasis. Journal Of Gastroenterology 1996, 31: 475-481. PMID: 8726846, DOI: 10.1007/bf02355044.
- Miller D, Fricker G, Schramm U, Henson J, Hager D, Nundy S, Ballatori N, Boyer J. Active microtubule-dependent secretion of a fluorescent bile salt derivative in skate hepatocyte clusters. American Journal Of Physiology 1996, 270: g887-g896. PMID: 8764193, DOI: 10.1152/ajpgi.1996.270.6.g887.
- Strazzabosco M, Boyer J. Regulation of intracellular pH in the hepatocyte Mechanisms and physiological implications. Journal Of Hepatology 1996, 24: 631-644. PMID: 8773922, DOI: 10.1016/s0168-8278(96)80153-x.
- Beuers U, Throckmorton D, Anderson, Isales C, Thasler W, Kullak-Ublick G, Sauter G, Koebe H, Paumgartner G, Boyer J. Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes. Gastroenterology 1996, 110: 1553-1563. PMID: 8613063, DOI: 10.1053/gast.1996.v110.pm8613063.
- Boyer J. Bile duct epithelium: frontiers in transport physiology. American Journal Of Physiology 1996, 270: g1-g5. PMID: 8772494, DOI: 10.1152/ajpgi.1996.270.1.g1.
- Jackson P, Churchwell K, Ballatori N, Boyer J, Strange K. Swelling-activated anion conductance in skate hepatocytes: regulation by cell Cl- and ATP. American Journal Of Physiology 1996, 270: c57-c66. PMID: 8772430, DOI: 10.1152/ajpcell.1996.270.1.c57.
- Gartung C, Ananthanarayanan M, Rahman M, Schuele S, Nundy S, Soroka C, Stolz A, Suchy F, Boyer J. Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis. Gastroenterology 1996, 110: 199-209. PMID: 8536857, DOI: 10.1053/gast.1996.v110.pm8536857.
- Combes B, Carithers R, Maddrey W, Lin D, McDonald M, Wheeler D, Eigenbrodt E, Muñoz S, Rubin R, Garcia-Tsao G, Bonner G, West A, Boyer J, Luketic V, Shiffman M, Mills A, Peters M, White H, Zetterman R, Rossi S, Hofmann A, Markin R. A randomized double-blind, placebo-controlled trial ursodeoxycholic acid in primary biliary cirrhosis. European Journal Of Gastroenterology & Hepatology 1995, 7: 1132. DOI: 10.1097/00042737-199511000-00024.
- Boyer J, Soroka C. Vesicle targeting to the apical domain regulates bile excretory function in isolated rat hepatocyte couplets. Gastroenterology 1995, 109: 1600-1611. PMID: 7557144, DOI: 10.1016/0016-5085(95)90649-5.
- Nundy S, Hager D, Kaljuvee J, Rexroad J, Ballatori N, Miller D, Boyer J. Carrier mediated uptake of Lucifer Yellow in liver of Raja erinacea, the small skate and the rat: A fluid phase marker revisited. Hepatology 1995, 22: a309. DOI: 10.1016/0270-9139(95)94958-5.
- Ballatori N, Truong A, Jackson P, Strange K, Boyer J. ATP depletion and inactivation of an ATP-sensitive taurine channel by classic ion channel blockers. Molecular Pharmacology 1995, 48: 472-6. PMID: 7565627.
- Combes B, Carithers R, Maddrey W, Lin D, Mcdonald M, Wheeler D, Eigenbrodt E, Muñoz S, Rubin R, Garcia-tsao G, Bonner G, West A, Boyer J, Luketic V, Shiffman M, Mills A, Peters M, White H, Zetterman R, Rossi S, Hofmann A, Markin R. A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid in primary biliary cirrhosis. Hepatology 1995, 22: 759-766. DOI: 10.1016/0270-9139(95)90294-5.
- Combes B, Carithers R, Maddrey W, Lin D, McDonald M, Wheeler D, Eigenbrodt E, Muñoz S, Rubin R, Garcia‐Tsao G, Bonner G, West A, Boyer J, Luketic V, Shiffman M, Mills A, Peters M, White H, Zetterman R, Rossi S, Hofmann A, Markin R. A randomized, double‐blind, placebo‐controlled trial of ursodeoxycholic acid in primary biliary cirrhosis. Hepatology 1995, 22: 759-766. PMID: 7657280, DOI: 10.1002/hep.1840220311.
- Mennone A, Alvaro D, Cho W, Boyer J. Isolation of small polarized bile duct units. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 6527-6531. PMID: 7541542, PMCID: PMC41551, DOI: 10.1073/pnas.92.14.6527.
- Felig D, Brusilow S, Boyer J. Hyperammonemic coma due to parenteral nutrition in a woman with heterozygous ornithine transcarbamylase deficiency. Gastroenterology 1995, 109: 282-284. PMID: 7797025, DOI: 10.1016/0016-5085(95)90295-3.
- Henson J, Capuano S, Nesbitt D, Hager D, Nundy S, Miller D, Ballatori N, Boyer J. Cytoskeletal organization in clusters of isolated polarized skate hepatocytes: Structural and functional evidence for microtubule‐dependent transcytosis. Journal Of Experimental Zoology 1995, 271: 273-284. PMID: 7722471, DOI: 10.1002/jez.1402710405.
- MAHL T, SHOCKCOR W, BOYER J. Primary Biliary Cirrhosis. Survey Of Anesthesiology 1995, 39: 61. DOI: 10.1097/00132586-199502000-00074.
- Jacquemin E, Hagenbuch B, Wolkoff A, Meier P, Boyer J. Expression of sodium-independent organic anion uptake systems of skate liver in Xenopus laevis oocytes. American Journal Of Physiology 1995, 268: g18-g23. PMID: 7840202, DOI: 10.1152/ajpgi.1995.268.1.g18.
- Bruck R, Nathanson M, Roelofsen H, Boyer J. Effects of protein kinase C and cytosolic Ca2+ on exocytosis in the isolated perfused rat liver. Hepatology 1994, 20: 1032-1040. PMID: 7927205, DOI: 10.1002/hep.1840200436.
- Ananthanarayanan M, Ng O, Boyer J, Suchy F. Characterization of cloned rat liver Na(+)-bile acid cotransporter using peptide and fusion protein antibodies. American Journal Of Physiology 1994, 267: g637-g643. PMID: 7943329, DOI: 10.1152/ajpgi.1994.267.4.g637.
- Ballatori N, Simmons T, Boyer J. A volume-activated taurine channel in skate hepatocytes: membrane polarity and role of intracellular ATP. American Journal Of Physiology 1994, 267: g285-g291. PMID: 7521136, DOI: 10.1152/ajpgi.1994.267.2.g285.
- Fricker G, Dubost V, Finsterwald K, Boyer J. Characteristics of bile salt uptake into skate hepatocytes. Biochemical Journal 1994, 299: 665-670. PMID: 8192655, PMCID: PMC1138072, DOI: 10.1042/bj2990665.
- Boyer J, Ng O, Ananthanarayanan M, Hofmann A, Schteingart C, Hagenbuch B, Stieger B, Meier P. Expression and characterization of a functional rat liver Na+ bile acid cotransport system in COS-7 cells. American Journal Of Physiology 1994, 266: g382-g387. PMID: 8166278, DOI: 10.1152/ajpgi.1994.266.3.g382.
- Benedetti A, Strazzabosco M, Ng O, Boyer J. Regulation of activity and apical targeting of the Cl-/HCO3- exchanger in rat hepatocytes. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 792-796. PMID: 8290601, PMCID: PMC43035, DOI: 10.1073/pnas.91.2.792.
- Mahl T, Shockcor W, Boyer J. Primary biliary cirrhosis: survival of a large cohort of symptomatic and asymptomatic patients followed for 24 years. Journal Of Hepatology 1994, 20: 707-713. PMID: 7930469, DOI: 10.1016/s0168-8278(05)80139-4.
- Blumrich M, Petzinger E, Boyer J. Characterization of bumetanide transport in isolated skate hepatocytes. American Journal Of Physiology 1993, 265: g926-g933. PMID: 8238522, DOI: 10.1152/ajpgi.1993.265.5.g926.
- Alvaro D, Mennone A, Boyer J. Effect of ursodeoxycholic acid on intracellular pH regulation in isolated rat bile duct epithelial cells. American Journal Of Physiology 1993, 265: g783-g791. PMID: 8238362, DOI: 10.1152/ajpgi.1993.265.4.g783.
- Alvaro D, Cho W, Mennone A, Boyer J. Effect of secretion on intracellular pH regulation in isolated rat bile duct epithelial cells. Journal Of Clinical Investigation 1993, 92: 1314-1325. PMID: 8397224, PMCID: PMC288273, DOI: 10.1172/jci116705.
- Bruck R, Benedetti A, Strazzabosco M, Boyer J. Intracellular alkalinization stimulates bile flow and vesicular-mediated exocytosis in IPRL. American Journal Of Physiology 1993, 265: g347-g353. PMID: 8368316, DOI: 10.1152/ajpgi.1993.265.2.g347.
- Beuers U, Nathanson M, Boyer J. Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes. Gastroenterology 1993, 104: 604-612. PMID: 8425704, DOI: 10.1016/0016-5085(93)90433-d.
- Garcia-Tsao G, Boyer J. Outpatient liver biopsy: how safe is it? Annals Of Internal Medicine 1993, 118: 150-3. PMID: 8416312, DOI: 10.7326/0003-4819-118-2-199301150-00013.
- Boyer J, Hagenbuch B, Ananthanarayanan M, Suchy F, Stieger B, Meier P. Phylogenic and ontogenic expression of hepatocellular bile acid transport. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 435-438. PMID: 8421672, PMCID: PMC45677, DOI: 10.1073/pnas.90.2.435.
- Boyer J, Graf J, Meier P. Hepatic Transport Systems Regulating pHi, Cell Volume, and Bile Secretion. Annual Review Of Physiology 1992, 54: 415-438. PMID: 1562181, DOI: 10.1146/annurev.ph.54.030192.002215.
- Hayakawa T, Katagiri K, Hoshino M, Nakai T, Ohiwa T, Kumai T, Miyaji M, Takeuchi T, Corasanti J, Boyer J. Papaverine inhibits transcytotic vesicle transport and lipid excretion into bile in isolated perfused rat liver. Hepatology 1992, 16: 1036-1042. PMID: 1398483, DOI: 10.1002/hep.1840160429.
- Sellinger M, Weinman S, Henderson R, Zweifach A, Boyer J, Graf J. Anion channels in rat liver canalicular plasma membranes reconstituted into planar lipid bilayers. American Journal Of Physiology 1992, 262: g1027-g1032. PMID: 1377450, DOI: 10.1152/ajpgi.1992.262.6.g1027.
- Bruck R, Haddad P, Graf J, Boyer J. Regulatory volume decrease stimulates bile flow, bile acid excretion, and exocytosis in isolated perfused rat liver. American Journal Of Physiology 1992, 262: g806-g812. PMID: 1590390, DOI: 10.1152/ajpgi.1992.262.5.g806.
- Ballatori N, Boyer J. Taurine transport in skate hepatocytes. II. Volume activation, energy, and sulfhydryl dependence. American Journal Of Physiology 1992, 262: g451-g460. PMID: 1550235, DOI: 10.1152/ajpgi.1992.262.3.g451.
- Ballatori N, Boyer J. Taurine transport in skate hepatocytes. I. Uptake and efflux. American Journal Of Physiology 1992, 262: g445-g450. PMID: 1550234, DOI: 10.1152/ajpgi.1992.262.3.g445.
- Boyer J, Shockcor W, Mahl T. The natural history of primary biliary cirrhosis. Transactions Of The American Clinical And Climatological Association 1992, 103: 157-63. PMID: 1413375, PMCID: PMC2376687.
- Nathanson M, Gautam A, Bruck R, Isales C, Boyer J. Effects of Ca2+ agonists on cytosolic Ca2+ in isolated hepatocytes and on bile secretion in the isolated perfused rat liver. Hepatology 1992, 15: 107-116. PMID: 1727785, DOI: 10.1002/hep.1840150119.
- Benedetti A, Strazzabosco M, Corasanti J, Haddad P, Graf J, Boyer J. Cl(-)-HCO3- exchanger in isolated rat hepatocytes: role in regulation of intracellular pH. American Journal Of Physiology 1991, 261: g512-g522. PMID: 1887897, DOI: 10.1152/ajpgi.1991.261.3.g512.
- Nathanson M, Boyer J. Mechanisms and regulation of bile secretion. Hepatology 1991, 14: 551-566. PMID: 1874500, DOI: 10.1002/hep.1840140324.
- Haddad P, Beck J, Boyer J, Graf J. Role of chloride ions in liver cell volume regulation. American Journal Of Physiology 1991, 261: g340-g348. PMID: 1872402, DOI: 10.1152/ajpgi.1991.261.2.g340.
- Strazzabosco M, Boyer J, Crepaldi G. The use of isolated rat hepatocyte couplets, microscopic optical planimetry and quantitative microfluorimetry in hepatobiliary physiology. Cytotechnology 1991, 5: 88-89. PMID: 22358966, DOI: 10.1007/bf00736820.
- Sellinger M, Ballatori N, Boyer J. Mechanism of mercurial inhibition of sodium-coupled alanine uptake in liver plasma membrane vesicles from Raja erinacea. Toxicology And Applied Pharmacology 1991, 107: 369-376. PMID: 1994517, DOI: 10.1016/0041-008x(91)90216-2.
- Strazzabosco M, Sakisaka S, Hayakawa T, Boyer J. Effect of UDCA on intracellular and biliary pH in isolated rat hepatocyte couplets and perfused livers. American Journal Of Physiology 1991, 260: g58-g69. PMID: 1987808, DOI: 10.1152/ajpgi.1991.260.1.g58.
- Hayakawa T, Bruck R, Ng O, Boyer J. DBcAMP stimulates vesicle transport and HRP excretion in isolated perfused rat liver. American Journal Of Physiology 1990, 259: g727-g735. PMID: 2173414, DOI: 10.1152/ajpgi.1990.259.5.g727.
- Hayakawa T, Cheng O, Ma A, Boyer J. Taurocholate stimulates transcytotic vesicular pathways labeled by horseradish peroxidase in the isolated perfused rat liver. Gastroenterology 1990, 99: 216-228. PMID: 2344927, DOI: 10.1016/0016-5085(90)91251-z.
- Graf J, Boyer J. The use of isolated rat hepatocyte couplets in hepatobiliary physiology. Journal Of Hepatology 1990, 10: 387-394. PMID: 2195112, DOI: 10.1016/0168-8278(90)90152-h.
- Simmons T, Moseley R, Boyer J, Ballatori N. Modulation of Na+/alanine cotransport in liver sinusoidal membrane vesicles by internal divalent cations. Biochimica Et Biophysica Acta 1990, 1023: 462-468. PMID: 2110482, DOI: 10.1016/0005-2736(90)90140-j.
- Gleeson D, Corasanti J, Boyer J. Effects of osmotic stresses on isolated rat hepatocytes. II. Modulation of intracellular pH. American Journal Of Physiology 1990, 258: g299-g307. PMID: 2305896, DOI: 10.1152/ajpgi.1990.258.2.g299.
- Corasanti J, Gleeson D, Boyer J. Effects of osmotic stresses on isolated rat hepatocytes. I. Ionic mechanisms of cell volume regulation. American Journal Of Physiology 1990, 258: g290-g298. PMID: 2305895, DOI: 10.1152/ajpgi.1990.258.2.g290.
- Sellinger M, Barrett C, Malle P, Gordon E, Boyer J. Cryptic na+, k+‐atpase activity in rat liver canalicular plasma membranes: Evidence for its basolateral origin. Hepatology 1990, 11: 223-229. PMID: 2155168, DOI: 10.1002/hep.1840110211.
- Boyer J, Meier P. [33] Characterizing mechanisms of hepatic bile acid transport utilizing isolated membrane vesicles. 1990, 192: 517-533. PMID: 2074806, DOI: 10.1016/0076-6879(90)92091-q.
- Boyer J, Phillips J, Graf J. [32] Preparation and specific applications of isolated hepatocyte couplets. 1990, 192: 501-516. PMID: 1963665, DOI: 10.1016/0076-6879(90)92090-z.
- Meier P, Boyer J. [34] Preparation of basolateral (sinusoidal) and canalicular plasma membrane vesicles for the study of hepatic transport processes. 1990, 192: 534-545. PMID: 1963666, DOI: 10.1016/0076-6879(90)92092-r.
- CORASANTI J, GLEESON D, BOYER J. Ionic Mechanisms of Cell Volume Regulation in Isolated Rat Hepatocytes. Annals Of The New York Academy Of Sciences 1989, 574: 385-387. DOI: 10.1111/j.1749-6632.1989.tb25172.x.
- SELLINGER M, WEINMAN S, HENDERSON R, ZWEIFACH A, BOYER J, GRAF J. Properties of an Anion Channel in Rat Liver Canalicular Membranes. Annals Of The New York Academy Of Sciences 1989, 574: 57-59. DOI: 10.1111/j.1749-6632.1989.tb25134.x.
- Gleeson D, Smith N, Boyer J. Bicarbonate-dependent and -independent intracellular pH regulatory mechanisms in rat hepatocytes. Evidence for Na+-HCO3- cotransport. Journal Of Clinical Investigation 1989, 84: 312-321. PMID: 2544626, PMCID: PMC303984, DOI: 10.1172/jci114156.
- Corasanti J, Smith N, Gordon E, Boyer J. Protein kinase C agonists inhibit bile secretion independently of effects on the microcirculation in the isolated perfused rat liver. Hepatology 1989, 10: 8-13. PMID: 2737605, DOI: 10.1002/hep.1840100103.
- Henderson R, Graf J, Boyer J. Inward-rectifying potassium channels in rat hepatocytes. American Journal Of Physiology 1989, 256: g1028-g1035. PMID: 2735409, DOI: 10.1152/ajpgi.1989.256.6.g1028.
- Weinman S, Graf J, Boyer J. Voltage-driven, taurocholate-dependent secretion in isolated hepatocyte couplets. American Journal Of Physiology 1989, 256: g826-g832. PMID: 2719107, DOI: 10.1152/ajpgi.1989.256.5.g826.
- Anderson J, Glade J, Stevenson B, Boyer J, Mooseker M. Hepatic immunohistochemical localization of the tight junction protein ZO-1 in rat models of cholestasis. American Journal Of Pathology 1989, 134: 1055-62. PMID: 2719075, PMCID: PMC1879891.
- Ballatori N, Truong A, K. A, Boyer J. Determinants of glutathione efflux and biliary GSH/GSSG ratio in perfused rat liver. American Journal Of Physiology 1989, 256: g482-g490. PMID: 2564253, DOI: 10.1152/ajpgi.1989.256.3.g482.
- Gautam A, Ng O, Strazzabosco M, Boyer J. Quantitative assessment of canalicular bile formation in isolated hepatocyte couplets using microscopic optical planimetry. Journal Of Clinical Investigation 1989, 83: 565-573. PMID: 2913052, PMCID: PMC303716, DOI: 10.1172/jci113919.
- Sellinger M, Weinman S, Boyer J, Graf J. Ion channels in canalicular rat liver plasma membranes. Journal Of Hepatology 1989, 9: s84. DOI: 10.1016/0168-8278(89)90344-9.
- Ballatori N, Wondergem R, Boyer J. Effect of l-alanine on membrane potential, potassium (86Rb) permeability and cell volume in hepatocytes from Raja erinacea. Biochimica Et Biophysica Acta 1988, 946: 261-269. PMID: 3207743, DOI: 10.1016/0005-2736(88)90401-4.
- Boyer J, Gautam A, Graf J. Mechanisms of Bile Secretion: lnsights from the Isolated Rat Hepatocyte Couplet. Seminars In Liver Disease 1988, 8: 308-316. PMID: 2850606, DOI: 10.1055/s-2008-1040552.
- Sakisaka S, Ng O, Boyer J. Tubulovesicular Transcytotic Pathway in Isolated Rat Hepatocyte Couplets in Culture Effect of Colchicine and Taurocholate. Gastroenterology 1988, 95: 793-804. PMID: 3396824, DOI: 10.1016/s0016-5085(88)80030-1.
- Ballatori N, Shi C, Boyer J. Altered plasma membrane ion permeability in mercury-induced cell injury: Studies in hepatocytes of elasmobranch Raja erinacea. Toxicology And Applied Pharmacology 1988, 95: 279-291. PMID: 2844008, DOI: 10.1016/0041-008x(88)90164-0.
- Henderson R, Krumpholz B, Boyer J, Graf J. Effect of intracellular pH on potassium conductance in liver. Pflügers Archiv - European Journal Of Physiology 1988, 412: 334-335. PMID: 3186436, DOI: 10.1007/bf00582518.
- Ballatori N, Boyer J. Characteristics of L-alanine uptake in freshly isolated hepatocytes of elasmobranch Raja erinacea. American Journal Of Physiology 1988, 254: r801-r808. PMID: 3364608, DOI: 10.1152/ajpregu.1988.254.5.r801.
- Ballatori N, Jacob R, Barrett C, Boyer J. Biliary catabolism of glutathione and differential reabsorption of its amino acid constituents. American Journal Of Physiology 1988, 254: g1-g7. PMID: 2892423, DOI: 10.1152/ajpgi.1988.254.1.g1.
- Fricker G, Hugentobler G, Meier P, Kurz G, Boyer J. Identification of a single sinusoidal bile salt uptake system in skate liver. American Journal Of Physiology 1987, 253: g816-g822. PMID: 3425718, DOI: 10.1152/ajpgi.1987.253.6.g816.
- Hugentobler G, Fricker G, Boyer J, Meier P. Anion transport in basolateral (sinusoidal) liver plasma-membrane vesicles of the little skate (Raja erinacea). Biochemical Journal 1987, 247: 589-595. PMID: 3426551, PMCID: PMC1148453, DOI: 10.1042/bj2470589.
- Graf J, Henderson R, Krumpholz B, Boyer J. Cell membrane and transepithelial voltages and resistances in isolated rat hepatocyte couplets. The Journal Of Membrane Biology 1987, 95: 241-254. PMID: 3585979, DOI: 10.1007/bf01869486.
- Moseley R, Ballatori N, Smith D, Boyer J. Ursodeoxycholate stimulates Na+-H+ exchange in rat liver basolateral plasma membrane vesicles. Journal Of Clinical Investigation 1987, 80: 684-690. PMID: 3040805, PMCID: PMC442291, DOI: 10.1172/jci113122.
- Helzberg J, Petersen J, Boyer J. Improved survival with primary sclerosing cholangitis A review of clinicopathologic features and comparison of symptomatic and asymptomatic patients. Gastroenterology 1987, 92: 1869-1875. PMID: 3569762, DOI: 10.1016/0016-5085(87)90618-4.
- Smith D, Grossbard M, Gordon E, Boyer J. Taurocholate uptake by isolated skate hepatocytes: effect of albumin. American Journal Of Physiology 1987, 252: g479-g484. PMID: 3565567, DOI: 10.1152/ajpgi.1987.252.4.g479.
- Meier P, Meier-Abt A, Boyer J. Properties of the canalicular bile acid transport system in rat liver. Biochemical Journal 1987, 242: 465-469. PMID: 3593261, PMCID: PMC1147728, DOI: 10.1042/bj2420465.
- Gautam A, Ng O, Boyer J. Isolated rat hepatocyte couplets in short‐term culture: Structural characteristics and plasma membrane reorganization. Hepatology 1987, 7: 216-223. PMID: 3557300, DOI: 10.1002/hep.1840070203.
- Smith D, Grossbard M, Gordon E, Boyer J. Isolation and characterization of a polarized isolated hepatocyte preparation in the skate Raja erinacea. Journal Of Experimental Zoology 1987, 241: 291-296. PMID: 3585270, DOI: 10.1002/jez.1402410303.
- Witzleben C, Boyer J, Ng O. Manganese-bilirubin cholestasis. Further studies in pathogenesis. Laboratory Investigation 1987, 56: 151-4. PMID: 3807313.
- Henderson R, Graf J, Boyer J. Na-H exchange regulates intracellular pH in isolated rat hepatocyte couplets. American Journal Of Physiology 1987, 252: g109-g113. PMID: 3028151, DOI: 10.1152/ajpgi.1987.252.1.g109.
- Grossbard M, Boyer J, Gordon E. The excretion pattern of biliverdin and bilirubin in bile of the small skate (Raja erinacea). Journal Of Comparative Physiology B 1987, 157: 61-66. PMID: 3571566, DOI: 10.1007/bf00702729.
- Boyer J. Mechanisms of Bile Secretion and Hepatic Transport. 1987, 225-252. DOI: 10.1007/978-1-4684-5404-8_12.
- Mills P, Meier P, Smith D, Ballatori N, Boyer J, Gordon E. The effect of changes in the fluid state of rat liver plasma membrane on the transport of taurocholate. Hepatology 1987, 7: 61-66. PMID: 3804206, DOI: 10.1002/hep.1840070114.
- Lorenzini I, Sakisaka S, Meier P, Boyer J. Demonstration of a Transcellular Vesicle Pathway for Biliary Excretion of Inulin in Rat Liver. Gastroenterology 1986, 91: 1278-1288. PMID: 3758619, DOI: 10.1016/s0016-5085(86)80028-2.
- Ballatori N, Boyer J. Slow biliary elimination of methyl mercury in the marine elasmobranchs, Raja erinacea and Squalus acanthias. Toxicology And Applied Pharmacology 1986, 85: 407-415. PMID: 3764924, DOI: 10.1016/0041-008x(86)90348-0.
- Ballatori N, Jacob R, Boyer J. Intrabiliary glutathione hydrolysis. A source of glutamate in bile. Journal Of Biological Chemistry 1986, 261: 7860-7865. PMID: 2872220, DOI: 10.1016/s0021-9258(19)57482-8.
- Ballatori N, Moseley R, Boyer J. Sodium gradient-dependent L-glutamate transport is localized to the canalicular domain of liver plasma membranes. Studies in rat liver sinusoidal and canalicular membrane vesicles. Journal Of Biological Chemistry 1986, 261: 6216-6221. PMID: 2871024, DOI: 10.1016/s0021-9258(19)84550-7.
- Boyer J. Mechanisms of Bile Secretion and Hepatic Transport. 1986, 609-636. DOI: 10.1007/978-1-4613-2097-5_35.
- Beswick D, Klatskin G, Boyer J. Asymptomatic primary biliary cirrhosis A progress report on long-term follow-up and natural history. Gastroenterology 1985, 89: 267-271. PMID: 4007417, DOI: 10.1016/0016-5085(85)90325-7.
- Meier P, Knickelbein R, Moseley R, Dobbins J, Boyer J. Evidence for carrier-mediated chloride/bicarbonate exchange in canalicular rat liver plasma membrane vesicles. Journal Of Clinical Investigation 1985, 75: 1256-1263. PMID: 2985654, PMCID: PMC425453, DOI: 10.1172/jci111824.
- Boyer J, Ng O, Gautam A. Formation of canalicular spaces in isolated rat hepatocyte couplets. Proceedings Of The Association Of American Physicians 1985, 98: 21-9. PMID: 2430357.
- Moseley R, Boyer J. Mechanisms of Electrolyte Transport in the Liver Their Functional Significance. Seminars In Liver Disease 1985, 5: 122-135. PMID: 3161181, DOI: 10.1055/s-2008-1063917.
- Mills P, Meier P, Boyer J, Gordon E. The effect of ethanol and calcium on fluid state of plasma membranes of rat hepatocytes. Alcohol 1985, 2: 153-156. PMID: 4015830, DOI: 10.1016/0741-8329(85)90034-5.
- Blitzer B, Boyer J. Localization of Na+,K+-ATPase on the Hepatocyte Plasma Membrane. Gastroenterology 1984, 87: 1206-1207. PMID: 6090261, DOI: 10.1016/s0016-5085(84)80097-9.
- Graf J, Gautam A, Boyer J. Isolated rat hepatocyte couplets: a primary secretory unit for electrophysiologic studies of bile secretory function. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 6516-6520. PMID: 6149546, PMCID: PMC391955, DOI: 10.1073/pnas.81.20.6516.
- Meier P, St Meier-Abt A, Barrett C, Boyer J. Mechanisms of taurocholate transport in canalicular and basolateral rat liver plasma membrane vesicles. Evidence for an electrogenic canalicular organic anion carrier. Journal Of Biological Chemistry 1984, 259: 10614-10622. PMID: 6469975, DOI: 10.1016/s0021-9258(18)91006-9.
- Gordon E, Meier P, Goresky C, Boyer J. Mechanism and subcellular site of bilirubin diglucuronide formation in rat liver. Journal Of Biological Chemistry 1984, 259: 5500-5506. PMID: 6715357, DOI: 10.1016/s0021-9258(18)91040-9.
- Weisiger R, Zacks C, Smith N, Boyer J. Effect of Albumin Binding on Extraction of Sulfobromophthalein by Perfused Elasmobranch Liver: Evidence for Dissociation‐Limited Uptake. Hepatology 1984, 4: 492-501. PMID: 6724517, DOI: 10.1002/hep.1840040323.
- Meier P, Sztul E, Reuben A, Boyer J. Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liver. Journal Of Cell Biology 1984, 98: 991-1000. PMID: 6699096, PMCID: PMC2113129, DOI: 10.1083/jcb.98.3.991.
- Beswick D, Boyer J. Primary Biliary Cirrhosis. Hepatology 1984, 4: 29s-32s. PMID: 6363257, DOI: 10.1002/hep.1840040710.
- Primor N, Zadunaisky J, Murdaugh H, Boyer J, Forrest J. Pardaxin increases solute permeability of gills and rectal gland in the dogfish shark (Squalus acanthias). Comparative Biochemistry And Physiology Part C Toxicology & Pharmacology 1984, 78: 483-490. PMID: 6149101, DOI: 10.1016/0742-8413(84)90119-1.
- Duffy M, Blitzer B, Boyer J. Direct determination of the driving forces for taurocholate uptake into rat liver plasma membrane vesicles. Journal Of Clinical Investigation 1983, 72: 1470-1481. PMID: 6630516, PMCID: PMC370431, DOI: 10.1172/jci111103.
- Easter D, Wade J, Boyer J. Structural integrity of hepatocyte tight junctions. Journal Of Cell Biology 1983, 96: 745-749. PMID: 6833382, PMCID: PMC2112395, DOI: 10.1083/jcb.96.3.745.
- Roll J, Boyer J, Barry D, Klatskin G. The Prognostic Importance of Clinical and Histologic Features in Asymptomatic and Symptomatic Primary Biliary Cirrhosis. New England Journal Of Medicine 1983, 308: 1-7. PMID: 6847917, DOI: 10.1056/nejm198301063080101.
- Boyer J, Allen R, Ng O. Biochemical Separation of Na+, K+‐ATPase from a “Purified” Light Density, “Canalicular”‐Enriched Plasma Membrane Fraction from Rat Liver. Hepatology 1983, 3: 18-28. PMID: 6130040, DOI: 10.1002/hep.1840030103.
- Reuben A, Howell K, Boyer J. Effects of taurocholate on the size of mixed lipid micelles and their associations with pigment and proteins in rat bile. Journal Of Lipid Research 1982, 23: 1039-1052. PMID: 7142812, DOI: 10.1016/s0022-2275(20)38077-9.
- Tavoloni N, Reed J, Boyer J. Effect of Chlorpromazine on Hepatic Clearance and Excretion of Bile Acids by the Isolated Perfused Rat Liver 1. Experimental Biology And Medicine 1982, 170: 486-492. PMID: 7122478, DOI: 10.3181/00379727-170-41463.
- Blitzer B, Boyer J. Reply. Gastroenterology 1982, 83: 160. DOI: 10.1016/s0016-5085(82)80320-x.
- Blitzer B, Boyer J. Reply. Gastroenterology 1982, 83: 161. DOI: 10.1016/s0016-5085(82)80322-3.
- Blitzer B, Ratoosh S, Donovan C, Boyer J. Effects of inhibitors of Na+-coupled ion transport on bile acid uptake by isolated rat hepatocytes. American Journal Of Physiology 1982, 243: g48-g53. PMID: 6283917, DOI: 10.1152/ajpgi.1982.243.1.g48.
- Forrest J, Boyer J, Ardito T, Murdaugh H, Wade J. Structure of tight junctions during Cl secretion in the perfused rectal gland of the dogfish shark. American Journal Of Physiology 1982, 242: c388-c392. PMID: 7081428, DOI: 10.1152/ajpcell.1982.242.5.c388.
- Reed J, Smith N, Boyer J. Determinants of biliary secretion in isolated perfused skate liver. American Journal Of Physiology 1982, 242: g319-g325. PMID: 7065254, DOI: 10.1152/ajpgi.1982.242.4.g319.
- Reed J, Smith N, Boyer J. Hemodynamic effects on oxygen consumption and bile flow in isolated skate liver. American Journal Of Physiology 1982, 242: g313-g318. PMID: 7065253, DOI: 10.1152/ajpgi.1982.242.4.g313.
- Blitzer B, Boyer J. Cellular mechanisms of bile formation. Gastroenterology 1982, 82: 346-357. PMID: 6274732, DOI: 10.1016/0016-5085(82)90027-0.
- Smith N, Boyer J. Permeability characteristics of bile duct in the rat. American Journal Of Physiology 1982, 242: g52-g57. PMID: 7058899, DOI: 10.1152/ajpgi.1982.242.1.g52.
- Lagarde S, Elias E, Wade J, Boyer J. Structural heterogeneity of hepatocyte “tight” junctions: A quantitative analysis. Hepatology 1981, 1: 193-203. PMID: 7286900, DOI: 10.1002/hep.1840010302.
- Haines N, Baker A, Boyer J, Glagov S, Schneir H, Jaspan J, Ferguson D. Prognostic indicators of hepatic injury following jejunoileal bypass performed for refractory obesity: A prospective study. Hepatology 1981, 1: 161-167. PMID: 7286895, DOI: 10.1002/hep.1840010212.
- Schneider J, Baker A, Haines N, Hatfield G, Boyer J. Aminopyrine n-Demethylation: A Prognostic test of liver function in patients with alcoholic liver disease. Gastroenterology 1980, 79: 1145-1150. PMID: 6777231, DOI: 10.1016/0016-5085(80)90906-3.
- Tavoloni N, Boyer J. Relationship between hepatic metabolism of chlorpromazine and cholestatic effects in the isolated perfused rat liver. Journal Of Pharmacology And Experimental Therapeutics 1980, 214: 269-74. PMID: 7391977.
- Reed J, Meredith S, Nemchausky B, Rosenberg I, Boyer J. Bone disease in primary biliary cirrhosis: Reversal of osteomalacia with oral 25-hydroxyvitamin D. Gastroenterology 1980, 78: 512-517. PMID: 7351289, DOI: 10.1016/0016-5085(80)90865-3.
- Elias E, Boyer J. Chlorpromazine and Its Metabolites Alter Polymerization and Gelation of Actin. Science 1979, 206: 1404-1406. PMID: 574316, DOI: 10.1126/science.574316.
- Stellaard F, Bolt M, Boyer J, Klein P. Phenobarbital treatment in primary biliary cirrhosis. Differences in bile acid composition between responders and nonresponders. Translational Research 1979, 94: 853-61. PMID: 501209.
- Tavoloni N, Reed J, Hruban Z, Boyer J. Effect of chlorpromazine on hepatic perfusion and bile secretory function in the isolated perfused rat liver. Translational Research 1979, 94: 726-41. PMID: 227976.
- Baker A, Wood R, Moossa A, Boyer J. Sodium Taurocholate Modifies the Bile Acid-Independent Fraction of Canalicular Bile Flow in the Rhesus Monkey. Journal Of Clinical Investigation 1979, 64: 312-320. PMID: 109471, PMCID: PMC372119, DOI: 10.1172/jci109453.
- Levin D, Baker A, Riddell R, Rochman H, Boyer J. Nonalcoholic liver disease Overlooked causes of liver injury in patients with heavy alcohol consumption. The American Journal Of Medicine 1979, 66: 429-434. PMID: 433949, DOI: 10.1016/0002-9343(79)91064-7.
- Baker A, Elson C, Jaspan J, Boyer J. Liver Failure With Steatonecrosis After Jejunoileal Bypass: Recovery With Parenteral Nutrition and Reanastomosis. JAMA Internal Medicine 1979, 139: 289-292. PMID: 106783, DOI: 10.1001/archinte.1979.03630400021012.
- Boyer J, Elias E, Layden T. The paracellular pathway and bile formation. The Yale Journal Of Biology And Medicine 1979, 52: 61-7. PMID: 452623, PMCID: PMC2595701.
- Hruban Z, Tavoloni N, Reed J, Boyer J. Ultrastructural changes during cholestasis induced by chlorpromazine in the isolated perfused rat liver. Cell Pathology 1978, 26: 289-305. DOI: 10.1007/bf02889557.
- Tavoloni N, Nemchausky B, Reed J, Boyer J. Metabolism affects the hepatic toxicity of chlorprohazine (CPZ) in the isolated perfused rat liver (IPRL). Gastroenterology 1978, 75: 990. DOI: 10.1016/0016-5085(78)90661-3.
- Blitzer B, Boyer J. Cytochemical localization of Na+, K+-ATPase in the rat hepatocyte. Journal Of Clinical Investigation 1978, 62: 1104-1108. PMID: 213446, PMCID: PMC371871, DOI: 10.1172/jci109216.
- Tavoloni N, Reed J, Boyer J. Hemodynamic effects on determinants of bile secretion in isolated rat liver. American Journal Of Physiology 1978, 234: e584. PMID: 665761, DOI: 10.1152/ajpendo.1978.234.6.e584.
- Haines N, Baker A, Glagov S, Ferguson D, Landau R, Boyer J. A prospective study of prognostic indicators of liver disease following jejunoileal bypass (JIB). Gastroenterology 1978, 74: 1170. DOI: 10.1016/0016-5085(78)93666-1.
- Schneider J, Schoeller D, Nemchausky B, Boyer J, Klein P. Validation of 13CO2 breath analysis as a measurement of demethylation of stable isotope labeled aminopyrine in man. Clinica Chimica Acta 1978, 84: 153-162. PMID: 639299, DOI: 10.1016/0009-8981(78)90489-8.
- Hruban Z, Tavoloni N, Reed J, Boyer J. Ultrastructural changes during cholestasis induced by chlorpromazine in the isolated perfused rat liver. Cell Pathology 1978, 26: 289-305. PMID: 416590, DOI: 10.1007/bf02889557.
- Bagheri S, Bolt M, Boyer J, Palmer R. Stimulation of thymidine incorporation in mouse liver and biliary tract epithelium by lithocholate and deoxycholate. Gastroenterology 1978, 74: 188-192. PMID: 620891, DOI: 10.1016/0016-5085(78)90793-x.
- Layden T, Boyer J. Taurolithocholate-Induced Cholestasis: Taurocholate, but not Dehydrocholate, Reverses Cholestasis and Bile Canalicular Membrane Injury. Gastroenterology 1977, 73: 120-128. PMID: 863183, DOI: 10.1016/s0016-5085(19)32283-8.
- Nemchausky B, Layden T, Boyer J. Effects of chronic choleretic infusions of bile acids on the membrane of the bile canaliculus. A biochemical and morphologic study. Laboratory Investigation 1977, 36: 259-67. PMID: 138767.
- WOOD R, BAKER A, HALL A, BOYER J, MOOSSA A. Evaluation of a New Monkey Model for the Repeated Study of Bile Secretory Physiology. Annals Of Surgery 1977, 185: 349-355. PMID: 402891, PMCID: PMC1396621, DOI: 10.1097/00000658-197703000-00017.
- Boyer J, Schwarz J, Smith N. Selective Hepatic Uptake and Biliary Excretion of 35S-Sulfobromophthalein in Marine Elasmobranchs. Gastroenterology 1976, 70: 254-256. PMID: 1248686, DOI: 10.1016/s0016-5085(76)80019-4.
- Layden T, Schwarz J, Boyer J. Scanning Electron Microscopy of the Rat Liver Studies of the effect of taurolithocholate and other models of cholestasis. Gastroenterology 1975, 69: 724-738. PMID: 1158090, DOI: 10.1016/s0016-5085(19)32475-8.
- Boyer J, Bloomer J, Maddrey W, Tilson D. Variation in hepatic bile composition following cholecystectomy in patients with previous gallstones. The Yale Journal Of Biology And Medicine 1974, 47: 211-7. PMID: 4456833, PMCID: PMC2595121.
- Hruban Z, Russell R, Boyer J, Glagov S, Bagheri S. Ultrastructural changes in livers of two patients with hypervitaminosis A. American Journal Of Pathology 1974, 76: 451-61. PMID: 4416771, PMCID: PMC1910880.
- Russell R, Boyer J, Bagheri S, Hruban Z. Hepatic Injury from Chronic Hypervitaminosis a Resulting in Portal Hypertension and Ascites. New England Journal Of Medicine 1974, 291: 435-440. PMID: 4843409, DOI: 10.1056/nejm197408292910903.
- Bloomer J, Boyer J, Klatskin G. Inhibition of Bilirubin Excretion in Man During Dehydrocholate Choleresis. Gastroenterology 1973, 65: 929-935. PMID: 4753351, DOI: 10.1016/s0016-5085(19)32986-5.
- Boyer J, Klatskin G. Canalicular Bile flow and Bile Secretory Pressure Evidence for a non-bile salt dependent fraction in the isolated perfused rat liver. Gastroenterology 1970, 59: 853-859. PMID: 5486271, DOI: 10.1016/s0016-5085(19)33645-5.
- Boyer J, Scheig R. Inhibition of Postheparin Lipolytic Activity in Uremia and its Relationship to Hypertriglyceridemia 1. Experimental Biology And Medicine 1970, 134: 603-605. PMID: 5431345, DOI: 10.3181/00379727-134-34842.
- Boyer J, Scheig R, Klatskin G. The effect of sodium taurocholate on the hepatic metabolism of sulfobromophthalein sodium (BSP). The role of bile flow. Journal Of Clinical Investigation 1970, 49: 206-215. PMID: 5411780, PMCID: PMC322462, DOI: 10.1172/jci106229.
- Boyer J, Scheig R. Hepatic metabolism of 1‐14C octanoic and 1‐14C margaric acids. Lipids 1969, 4: 615-617. PMID: 5367946, DOI: 10.1007/bf02531049.
- Yale Digestive DiseasesTemple Medical Center40 Temple Street, Ste Suite 1ANew Haven, CT 06510
- Yale Digestive DiseasesYale New Haven Hospital20 York StreetNew Haven, CT 06510
Biography
James L. Boyer, MD, specializes in liver diseases, a field he decided to pursue during a stint with the U.S. Health Service in Calcutta, India, during his medical residency. He views each case as unique and approaches each patient with flexibility. “It is important to emphasize that each patient's condition is different and not necessarily as described classically in a textbook or online, and that there is a great deal that we can do to help,” he says.
A professor of medicine (digestive diseases) at Yale School of Medicine, Dr. Boyer is also emeritus director of the Yale Liver Center, which he founded, and he has worked to improve care on a national level serving such organizations as the American Liver Foundation.
Dr. Boyer focuses his clinical practice on autoimmune and cholestatic liver diseases, which can lead to cirrhosis, and is optimistic about recent advances in the understanding of these ailments. “There are many new treatments in development that look promising,” he says. His most memorable patient was the first patient he recommended for a liver transplant. She was a young woman with cirrhosis who doctors predicted would die in several years. Under Dr. Boyer’s care, she lived another 46 years.
Titles
- Ensign Professor of Medicine (Digestive Diseases)
- Emeritus Director, Yale Liver Center
Education & Training
- FellowYale School of Medicine (1969)
- ResidentYale - New Haven Hospital (1967)
- ResidentNew York Hospital (1964)
- MDJohns Hopkins University (1962)
- ABHaverford College, Biology (1958)
Additional Information
- Emeritus Director, Yale Liver Center: (2020)
- International Recognition Award: European Association for the Study of Liver Disease (2019)
- Johns Hopkins Society of Scholars -2016: Johns Hopkins University (2016)
- Spinoza Profesesorship: University of Amsterdam, the Netherlands (2009)
- NIH MERIT Award: National Institutes of Health (2008)
- Distinguished Scientific Achievement Award: American Liver foundation (1999)
- Distinguished Achievement Award: American Association for the Study of the Liver (1998)
- Ismar-Boas Medal: German Society of Gastroenterology and Metabolism (1996)
- Ensign Professorship: Yale University (1996)
- Distinguished Achievement Award: American Gastroenterology Association (1989)
- AB of Internal Medicine, Internal Medicine (1969)
- Haverford College (2009 - Present): Board Member
- Mt Desert Island Biological Laboratory (1995 - 2013): Board Member
- American Liver Foundation (1976 - Present): voluntary health agency
- Yale University School of Medicine: Committee Member
- Du Y, de Jong I, Gupta K, Waisbourd-Zinman O, Har-Zahav A, Soroka C, Boyer J, Llewellyn J, Liu C, Naji A, Polacheck W, Wells R. Human vascularized bile duct-on-a chip: a multi-cellular micro-physiological system for studying cholestatic liver disease. Biofabrication 2023, 16: 015004. PMID: 37820623, PMCID: PMC10587873, DOI: 10.1088/1758-5090/ad0261.
- Boyer J. Bile Acid Induced Inflammation and the Role of β-Catenin. Cellular And Molecular Gastroenterology And Hepatology 2023, 16: 1033. PMID: 37690462, PMCID: PMC10685134, DOI: 10.1016/j.jcmgh.2023.08.009.
- Pan Q, Zhu G, Xu Z, Zhu J, Ouyang J, Tong Y, Zhao N, Zhang X, Cheng Y, Zhang L, Tan Y, Li J, Zhang C, Chen W, Cai S, Boyer J, Chai J. Organic Anion Transporting Polypeptide (OATP) 1B3 is a Significant Transporter for Hepatic Uptake of Conjugated Bile Acids in Humans. Cellular And Molecular Gastroenterology And Hepatology 2023, 16: 223-242. PMID: 37146714, PMCID: PMC10394288, DOI: 10.1016/j.jcmgh.2023.04.007.
- Li X, Li Y, Xiao J, Wang H, Guo Y, Mao X, Shi P, Hou Y, Zhang X, Zhao N, Zheng M, He Y, Ding J, Tan Y, Liao M, Li L, Peng Y, Li X, Pan Q, Xie Q, Li Q, Li J, Li Y, Chen Z, Huang Y, Assis DN, Cai SY, Boyer JL, Huang X, Tang CE, Liu X, Peng S, Chai J. Unique DUOX2(+)ACE2(+) small cholangiocytes are pathogenic targets for primary biliary cholangitis. Nat Commun 2023, 14: 29. PMID: 36759512, DOI: 10.1038/s41467-022-34606-w.
- Zhang L, Pan Q, Zhang L, Xia H, Liao J, Zhang X, Zhao N, Xie Q, Liao M, Tan Y, Li Q, Zhu J, Li L, Fan S, Li J, Zhang C, Cai S, Boyer J, Chai J. Runt-related transcription factor-1 ameliorates bile acid–induced hepatic inflammation in cholestasis through JAK/STAT3 signaling. Hepatology 2023, 77: 1866-1881. PMID: 36647589, PMCID: PMC10921919, DOI: 10.1097/hep.0000000000000041.
- Gallucci GM, Trottier J, Hemme C, Assis DN, Boyer JL, Barbier O, Ghonem NS. Adjunct Fenofibrate Up‐regulates Bile Acid Glucuronidation and Improves Treatment Response For Patients With Cholestasis. Hepatology Communications 2021, 5: 2035-2051. PMID: 34558841, PMCID: PMC8631103, DOI: 10.1002/hep4.1787.
- Stieger B, Boyer JL. In Memoriam: Peter J. Meier (1947–2021). Journal Of Hepatology 2021, 75: 761-762. DOI: 10.1016/j.jhep.2021.06.039.
- Efe C, Dhanasekaran R, Lammert C, Ebik B, la Tijera F, Aloman C, Calışkan A, Peralta M, Gerussi A, Massoumi H, Catana AM, Torgutalp M, Purnak T, Rigamonti C, Aldana A, Khakoo N, Kacmaz H, Nazal L, Frager S, Demir N, Irak K, Ellik ZM, Balaban Y, Atay K, Eren F, Cristoferi L, Batıbay E, Urzua Á, Snijders R, Kıyıcı M, Akyıldız M, Ekin N, Carr RM, Harputluoğlu M, Hatemi I, Mendizabal M, Silva M, Idilman R, Silveira M, Drenth JPH, Assis DN, Björnsson E, Boyer JL, Invernizzi P, Levy C, Schiano TD, Ridruejo E, Wahlin S. Outcome of COVID‐19 in Patients With Autoimmune Hepatitis: An International Multicenter Study. Hepatology 2021, 73: 2099-2109. PMID: 33713486, PMCID: PMC8250536, DOI: 10.1002/hep.31797.
- Soroka CJ, Roberts SJ, Boyer JL, Assis DN. Role of Biliary Organoids in Cholestasis Research and Regenerative Medicine. Seminars In Liver Disease 2021, 41: 206-212. PMID: 33957696, DOI: 10.1055/s-0041-1728663.
- Cai SY, Boyer JL. The role of bile acids in cholestatic liver injury. Annals Of Translational Medicine 2021, 9: 737-737. PMID: 33987435, PMCID: PMC8106037, DOI: 10.21037/atm-20-5110.
- Boyer JL, Soroka CJ. Bile formation and secretion: An update. Journal Of Hepatology 2021, 75: 190-201. PMID: 33617926, DOI: 10.1016/j.jhep.2021.02.011.
- Li B, Cai SY, Boyer JL. The role of the retinoid receptor, RAR/RXR heterodimer, in liver physiology. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease 2021, 1867: 166085. PMID: 33497820, DOI: 10.1016/j.bbadis.2021.166085.
- Cai SY, Yu D, Soroka CJ, Wang J, Boyer JL. Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis. Journal Of Hepatology 2020, 74: 550-559. PMID: 33039404, PMCID: PMC7897288, DOI: 10.1016/j.jhep.2020.09.035.
- Soroka C, Roberts S, Hohenester S, Boyer J, Assis D. AS055 Co-culture of bile-derived organoids from primary sclerosing cholangitis patients with CD4+ T cells replicates pathogenic, CCL20 dependent biliary-immune interactions. Journal Of Hepatology 2020, 73: s41. DOI: 10.1016/s0168-8278(20)30634-6.
- Ghonem NS, Auclair AM, Hemme CL, Gallucci GM, de la Rosa Rodriguez R, Boyer JL, Assis DN. Fenofibrate Improves Liver Function and Reduces the Toxicity of the Bile Acid Pool in Patients With Primary Biliary Cholangitis and Primary Sclerosing Cholangitis Who Are Partial Responders to Ursodiol. Clinical Pharmacology & Therapeutics 2020, 108: 1213-1223. PMID: 32480421, PMCID: PMC7886378, DOI: 10.1002/cpt.1930.
- Gao E, Cheema H, Waheed N, Mushtaq I, Erden N, Nelson‐Williams C, Jain D, Soroka CJ, Boyer JL, Khalil Y, Clayton PT, Mistry PK, Lifton RP, Vilarinho S. Organic Solute Transporter Alpha Deficiency: A Disorder With Cholestasis, Liver Fibrosis, and Congenital Diarrhea. Hepatology 2020, 71: 1879-1882. PMID: 31863603, PMCID: PMC8577800, DOI: 10.1002/hep.31087.
- Gigliozzi A, Fraioli F, Boyer J. Hormonal Regulation of Cholangiocyte Secretion. 2020, 89-95. DOI: 10.1201/9780367813888-8.
- Boyer J. Adaptive Regulation of Hepatocyte Transporters in Cholestasis. 2020, 378-389. DOI: 10.1002/9781119436812.ch31.
- Cai S, Li M, Boyer J. The Role of Bile Acid‐Mediated Inflammation in Cholestatic Liver Injury. 2020, 728-736. DOI: 10.1002/9781119436812.ch56.
- Lindor K, Bowlus C, Boyer J, Levy C, Mayo M. Primary Biliary Cholangitis: 2018 Practice Guidance From the American Association for the Study of Liver Diseases. Clinical Liver Disease 2020, 15: 1-2. PMCID: PMC7041951, DOI: 10.1002/cld.874.
- Cai SY, Ge M, Mennone A, Hoque R, Ouyang X, Boyer JL. Inflammasome Is Activated in the Liver of Cholestatic Patients and Aggravates Hepatic Injury in Bile Duct–Ligated Mouse. Cellular And Molecular Gastroenterology And Hepatology 2019, 9: 679-688. PMID: 31887435, PMCID: PMC7160576, DOI: 10.1016/j.jcmgh.2019.12.008.
- Soroka CJ, Assis DN, Alrabadi LS, Roberts S, Cusack L, Jaffe AB, Boyer JL. Bile‐Derived Organoids From Patients With Primary Sclerosing Cholangitis Recapitulate Their Inflammatory Immune Profile. Hepatology 2019, 70: 871-882. PMID: 30561836, DOI: 10.1002/hep.30470.
- Soroka CJ, Assis DN, Boyer JL. Patient-Derived Organoids from Human Bile: An In Vitro Method to Study Cholangiopathies. 2019, 1981: 363-372. PMID: 31016667, DOI: 10.1007/978-1-4939-9420-5_24.
- Cai S, Boyer JL. Bile Infarcts: New Insights Into the Pathogenesis of Obstructive Cholestasis. Hepatology 2019, 69: 473-475. PMID: 30251326, DOI: 10.1002/hep.30291.
- Lindor KD, Bowlus CL, Boyer J, Levy C, Mayo M. Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases. Hepatology 2019, 69: 394-419. PMID: 30070375, DOI: 10.1002/hep.30145.
- Pan Q, Zhang X, Zhang L, Cheng Y, Zhao N, Li F, Zhou X, Chen S, Li J, Xu S, Huang D, Chen Y, Li L, Wang H, Chen W, Cai SY, Boyer JL, Chai J. Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis. Gastroenterology 2018, 155: 1578-1592.e16. PMID: 30063921, PMCID: PMC6221191, DOI: 10.1053/j.gastro.2018.07.031.
- Yu D, Cai S, Mennone A, Vig P, Boyer JL. Cenicriviroc, a cytokine receptor antagonist, potentiates all‐trans retinoic acid in reducing liver injury in cholestatic rodents. Liver International 2018, 38: 1128-1138. PMID: 29356312, PMCID: PMC6032984, DOI: 10.1111/liv.13698.
- Boyer JL. OSTα-OSTβ Guards the Ileal Enterocyte From the Accumulation of Toxic Levels of Bile Acids. Cellular And Molecular Gastroenterology And Hepatology 2018, 5: 649-650. PMID: 29713669, PMCID: PMC5924743, DOI: 10.1016/j.jcmgh.2018.01.015.
- Goldberg DS, Levy C, Yimam K, Gordon SC, Forman L, Verna E, Yu L, Rahimi R, Schwarz K, Eksteen B, Pratt D, Boyer JL, Assis D, Bowlus C. Primary Sclerosing Cholangitis Is Not Rare Among Blacks in a Multicenter North American Consortium. Clinical Gastroenterology And Hepatology 2017, 16: 591-593. PMID: 29102704, PMCID: PMC5860952, DOI: 10.1016/j.cgh.2017.10.028.
- Li M, Cai SY, Boyer JL. Mechanisms of bile acid mediated inflammation in the liver. Molecular Aspects Of Medicine 2017, 56: 45-53. PMID: 28606651, PMCID: PMC5662014, DOI: 10.1016/j.mam.2017.06.001.
- Boyer JL. Maintaining a Vibrant and Productive Laboratory as a Senior Investigator. Cellular And Molecular Gastroenterology And Hepatology 2017, 4: 299-300. PMID: 28840184, PMCID: PMC5560913, DOI: 10.1016/j.jcmgh.2017.04.008.
- Cai SY, Ouyang X, Chen Y, Soroka CJ, Wang J, Mennone A, Wang Y, Mehal WZ, Jain D, Boyer JL. Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response. JCI Insight 2017, 2: e90780. PMID: 28289714, PMCID: PMC5333973, DOI: 10.1172/jci.insight.90780.
- Assis DN, Abdelghany O, Cai SY, Gossard AA, Eaton JE, Keach JC, Deng Y, Setchell KD, Ciarleglio M, Lindor KD, Boyer JL. Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis. Journal Of Clinical Gastroenterology 2017, 51: e11-e16. PMID: 27428727, PMCID: PMC5218875, DOI: 10.1097/mcg.0000000000000591.
- Roberts S, Leng L, Soroka C, Boyer J, Bucala R, Assis D. FRI-393 Macrophage migration inhibitory factor (MIF) modulates T-cell proliferation and hepatic inflammation in a model of autoimmune liver disease. Journal Of Hepatology 2017, 66: s363-s364. DOI: 10.1016/s0168-8278(17)31067-x.
- Cai SY, Boyer JL. Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury. Inflammation And Cell Signaling 2017, 4 PMID: 28804737, PMCID: PMC5553904, DOI: 10.14800/ics.1561.
- Kulkarni SR, Soroka CJ, Hagey LR, Boyer JL. Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid–fed mouse model of cholestasis. Hepatology 2016, 64: 2151-2164. PMID: 27639250, PMCID: PMC5115990, DOI: 10.1002/hep.28826.
- Li M, Soroka CJ, Harry K, Boyer JL. CFTR-associated ligand is a negative regulator of Mrp2 expression. American Journal Of Physiology - Cell Physiology 2016, 312: c40-c46. PMID: 27834195, PMCID: PMC5283898, DOI: 10.1152/ajpcell.00100.2016.
- Xu S, Soroka CJ, Sun AQ, Backos DS, Mennone A, Suchy FJ, Boyer JL. A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization. PLOS ONE 2016, 11: e0158269. PMID: 27351185, PMCID: PMC4924846, DOI: 10.1371/journal.pone.0158269.
- Li M, Mennone A, Soroka CJ, Hagey LR, Ouyang X, Weinman EJ, Boyer JL. Na+/H+ exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury. Hepatology 2015, 62: 1227-1236. PMID: 26108984, PMCID: PMC4589453, DOI: 10.1002/hep.27956.
- Ghonem NS, Assis DN, Boyer JL. Fibrates and cholestasis. Hepatology 2015, 62: 635-643. PMID: 25678132, PMCID: PMC4515188, DOI: 10.1002/hep.27744.
- Chai J, Cai SY, Liu X, Lian W, Chen S, Zhang L, Feng X, Cheng Y, He X, He Y, Chen L, Wang R, Wang H, Boyer JL, Chen W. Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis. Journal Of Hepatology 2015, 63: 1440-1448. PMID: 26212029, PMCID: PMC4686151, DOI: 10.1016/j.jhep.2015.07.016.
- Boyer JL. The origins of hepatobiliary and gastrointestinal physiology. Hepatology 2015, 61: 1452-1454. PMID: 25677183, PMCID: PMC4447183, DOI: 10.1002/hep.27737.
- Assis DN, Leng L, Du X, Zhang CK, Grieb G, Merk M, Garcia AB, McCrann C, Chapiro J, Meinhardt A, Mizue Y, Nikolic‐Paterson D, Bernhagen J, Kaplan MM, Zhao H, Boyer JL, Bucala R. The role of macrophage migration inhibitory factor in autoimmune liver disease. Hepatology 2013, 59: 580-591. PMID: 23913513, PMCID: PMC3877200, DOI: 10.1002/hep.26664.
- Boyer JL. Bile Formation and Secretion. 2013, 3: 1035-1078. PMID: 23897680, PMCID: PMC4091928, DOI: 10.1002/cphy.c120027.
- Plotkin E, Assis D, Boyer J. Now you see it, now you don't. Hepatology 2013, 58: 446-447. DOI: 10.1002/hep.26439.
- Cai S, Lionarons DA, Hagey L, Soroka CJ, Mennone A, Boyer JL. Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion. Hepatology 2013, 57: 2418-2426. PMID: 23175353, PMCID: PMC3604052, DOI: 10.1002/hep.26161.
- Soroka CJ, Boyer JL. Biosynthesis and trafficking of the bile salt export pump, BSEP: Therapeutic implications of BSEP mutations. Molecular Aspects Of Medicine 2013, 37: 3-14. PMID: 23685087, PMCID: PMC3784619, DOI: 10.1016/j.mam.2013.05.001.
- Lam P, Xu S, Soroka CJ, Boyer JL. A C‐terminal tyrosine‐based motif in the bile salt export pump directs clathrin‐dependent endocytosis. Hepatology 2012, 55: 1901-1911. PMID: 22161577, PMCID: PMC3319652, DOI: 10.1002/hep.25523.
- Boyer J, Garcia‐Tsao G, Groszmann R. In Memoriam: Harold O. Conn, M.D. Hepatology 2012, 55: 658-658. DOI: 10.1002/hep.25550.
- Soroka CJ, Velazquez H, Mennone A, Ballatori N, Boyer JL. Ostα depletion protects liver from oral bile acid load. AJP Gastrointestinal And Liver Physiology 2011, 301: g574-g579. PMID: 21719738, PMCID: PMC3174539, DOI: 10.1152/ajpgi.00141.2011.
- Padda MS, Sanchez M, Akhtar AJ, Boyer JL. Drug‐induced cholestasis. Hepatology 2011, 53: 1377-1387. PMID: 21480339, PMCID: PMC3089004, DOI: 10.1002/hep.24229.
- He H, Mennone A, Boyer JL, Cai S. Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct–ligated rats and human hepatic cells. Hepatology 2010, 53: 548-557. PMID: 21274875, PMCID: PMC3069505, DOI: 10.1002/hep.24047.
- Lam P, Soroka C, Boyer J. The Bile Salt Export Pump: Clinical and Experimental Aspects of Genetic and Acquired Cholestatic Liver Disease. Seminars In Liver Disease 2010, 30: 125-133. PMID: 20422495, PMCID: PMC3008346, DOI: 10.1055/s-0030-1253222.
- Boyer J. Cholestasis: Genetic and Acquired. Seminars In Liver Disease 2010, 30: 113-115. PMID: 20422493, DOI: 10.1055/s-0030-1253220.
- Azzaroli F, Mennone A, Raspanti M, Longo M, Turco L, Buonfiglioli F, Giandinoto M, Roda E, Mazzella N, Lodato F, Montagnani M, Boyer J, Mazzella G. 912 UDCA UP-REGULATES HUMAN PLACENTAL OATP-A MRNA EXPRESSION. Journal Of Hepatology 2010, 52: s354. DOI: 10.1016/s0168-8278(10)60913-0.
- Azzaroli F, Mennone A, Raspanti M, Longo M, Montagnani M, Turco L, Buonfiglioli F, Giandinoto M, Lodato F, Roda E, Lisotti A, Cecinato P, Boyer J, Mazzella G. P.237 UDCA UP-REGULATES HUMAN PLACENTAL OATP-A EXPRESSION IN INTRAHEPATIC CHOLESTASIS OF PREGNANCY. Digestive And Liver Disease 2010, 42: s185. DOI: 10.1016/s1590-8658(10)60349-0.
- Azzaroli F, Mennone A, Raspanti M, Longo M, Montagnani M, Turco L, Buonfiglioli F, Giandinoto M, Lodato F, Lisotti A, Cecinato P, Roda E, Boyer J, Mazzella G. T.N.4 UDCA UP-REGULATES HUMAN PLACENTAL OATP-A EXPRESSION IN INTRAHEPATIC CHOLESTASIS OF PREGNANCY. Digestive And Liver Disease 2010, 42: s16. DOI: 10.1016/s1590-8658(10)60409-4.
- Boyer J. Adaptive Regulation of Hepatocyte Transporters in Cholestasis. 2009, 681-702. DOI: 10.1002/9780470747919.ch43.
- Boyer JL. It's all about bile. Hepatology 2009, 49: 711-723. PMID: 19242972, DOI: 10.1002/hep.22719.
- Cai S, Gautam S, Nguyen T, Soroka C, Rahner C, Boyer J. Fic1-deficient rat hepatocytes reveal structural and functional defects in the bile canalicular membrane when exposed to hydrophobic bile acids. 2009, 18-20. DOI: 10.1007/978-1-4020-9644-0_3.
- Cai S, Gautam S, Nguyen T, Soroka CJ, Rahner C, Boyer JL. ATP8B1 Deficiency Disrupts the Bile Canalicular Membrane Bilayer Structure in Hepatocytes, But FXR Expression and Activity Are Maintained. Gastroenterology 2008, 136: 1060-1069.e4. PMID: 19027009, PMCID: PMC3439851, DOI: 10.1053/j.gastro.2008.10.025.
- Nava G, Lee D, Cai S, Boyer J, Hernández‐Zavala A, Thomas D, Gaskins H. Arsenic (+3 oxidation state) methyltransferase and the methylation of arsenicals in the invertebrate chordate Ciona intestinalis. The FASEB Journal 2008, 22: 796.1-796.1. DOI: 10.1096/fasebj.22.1_supplement.796.1.
- AZZAROLI F, MENNONE A, FELETTI V, SIMONI P, BAGLIVO E, MONTAGNANI M, RIZZO N, PELUSI G, DE ALOYSIO D, LODATO F, FESTI D, COLECCHIA A, RODA E, BOYER J, MAZZELLA G. Clinical trial: modulation of human placental multidrug resistance proteins in cholestasis of pregnancy by ursodeoxycholic acid. Alimentary Pharmacology & Therapeutics 2007, 26: 1139-1146. PMID: 17894656, DOI: 10.1111/j.1365-2036.2007.03462.x.
- Soroka C, Xu S, Cai S, Ballatori N, Boyer J. Insights into the regulation of expression of human OSTα-OSTβ. 2007, 155: 53-56. DOI: 10.1007/978-1-4020-6252-0_7.
- Meier-Abt F, Hammann-Hänni A, Stieger B, Ballatori N, Boyer J. The organic anion transport polypeptide 1d1 (Oatp1d1) mediates hepatocellular uptake of phalloidin and microcystin into skate liver. Toxicology And Applied Pharmacology 2006, 218: 274-279. PMID: 17198718, DOI: 10.1016/j.taap.2006.11.015.
- Azzaroli F, Feletti V, Mennone A, Simoni P, Maglinolo M, Baglivo E, Rizzo N, Lodato F, Festi D, Colecchia A, Roda A, Roda E, Boyer J, Mazzella G. Modulation of placental bilirubin and bile acids transporters during cholestasis of pregnancy. Digestive And Liver Disease 2006, 38: s97-s98. DOI: 10.1016/s1590-8658(06)80260-4.
- Azzaroli E, Mennone A, Feletti V, Simoni P, Magliuolo M, Baglivo E, Rizzo N, Lodato E, Festi D, Colecchia A, Roda A, Roch E, Boyer J, Mazzella G. 627 Modulation of placental bilirubin and bile acids transporters during cholestasis of pregnancy. Journal Of Hepatology 2006, 44: s233. DOI: 10.1016/s0168-8278(06)80627-6.
- Boyer J, Chen W, Cai S, Denk G, Bohan A, Soroka C, Denson L. Adaptive regulation of bile salt transporters in cholestasis. 2005, 144: 186-188. DOI: 10.1007/1-4020-2916-0_16.
- Chen W, Bohan A, Denk G, Soroka C, Denson L, Boyer J. Adaptive regulation of bile salt transporters in cholestasis — the role of MRPs. 2005, 141: 130-131. DOI: 10.1007/1-4020-2913-6_17.
- Mattingly C, Colby G, Rosenstein M, Forrest J, Boyer J. Promoting comparative molecular studies in environmental health research: an overview of the comparative toxicogenomics database (CTD). The Pharmacogenomics Journal 2004, 4: 5-8. PMID: 14735110, DOI: 10.1038/sj.tpj.6500225.
- Bohan A, Chen W, Denson L, Held M, Boyer J. 27 MRP3/MRP3(ABCC3/ABCC3) is up-regulated by TNF α via (cholesterol 7 α hydroxylase promoter factor (CPF) and is hepatoprotective in obstructive cholestasis. Hepatology 2003, 38: 168. DOI: 10.1016/s0270-9139(03)80070-8.
- Chen W, Denson L, Bohan A, Cai S, Wang L, Soroka C, Boyer J. 82 The cholesterol-7α hydroxylase promoter factor (CPF) up-regulates the human multidrug resistance-associated protein 3 (MRP3) and is induced by bile salts in HEPG2 cells. Hepatology 2003, 38: 195. DOI: 10.1016/s0270-9139(03)80125-8.
- Mattingly C, Colby G, Forrest J, Boyer J. The Comparative Toxicogenomics Database (CTD). Environmental Health Perspectives 2003 DOI: 10.1289/txg.6028.
- Soroka C, Mennone A, Boyer J. 1102 Susceptibility to estrogen induced cholestasis in the female is associated with loss of radixin, an MRP2 tethering protein, from the canalicular membrane. Hepatology 2003, 38: 687. DOI: 10.1016/s0270-9139(03)81140-0.
- Denk G, Soroka C, Mennone A, Koepsell H, Beuers U, Boyer J. 26 Obstructive cholestasis results in down-regulation and functional impairment of the organic cation transporter 1 (OCT1) in rat. Hepatology 2003, 38: 168. DOI: 10.1016/s0270-9139(03)80069-1.
- Bohan A, Boyer J. Mechanisms of Hepatic Transport of Drugs: Implications for Cholestatic Drug Reactions. Seminars In Liver Disease 2002, 22: 123-136. PMID: 12016544, DOI: 10.1055/s-2002-30099.
- Lee J, Azzaroli F, Wang L, Soroka C, Gigliozzi A, Setchell K, Kramer W, Boyer J. Adaptive regulation of bile salt transporters in kidney and liver in obstructive cholestasis in the rat. Gastroenterology 2001, 121: 1473-1484. PMID: 11729126, DOI: 10.1053/gast.2001.29608.
- Singh S, Mennone A, Gigliozzi A, Fraioli F, Boyer J. Cl−-dependent secretory mechanisms in isolated rat bile duct epithelial units. AJP Gastrointestinal And Liver Physiology 2001, 281: g438-g446. PMID: 11447024, DOI: 10.1152/ajpgi.2001.281.2.g438.
- Cai S, Wang L, Ballatori N, Boyer J. Bile salt export pump is highly conserved during vertebrate evolution and its expression is inhibited by PFIC type II mutations. AJP Gastrointestinal And Liver Physiology 2001, 281: g316-g322. PMID: 11447010, DOI: 10.1152/ajpgi.2001.281.2.g316.
- Wang W, Seward D, Li L, Boyer J, Ballatori N. Expression cloning of two genes that together mediate organic solute and steroid transport in the liver of a marine vertebrate. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 9431-9436. PMID: 11470901, PMCID: PMC55438, DOI: 10.1073/pnas.161099898.
- Trauner M, Boyer J. Cholestatic syndromes. Current Opinion In Gastroenterology 2001, 17: 242-256. PMID: 17031165, DOI: 10.1097/00001574-200105000-00007.
- Soroka C, Lee J, Azzaroli F, Boyer J. Cellular localization and up‐regulation of multidrug resistance–associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver. Hepatology 2001, 33: 783-791. PMID: 11283840, DOI: 10.1053/jhep.2001.23501.
- Boyer J. Advancing the bile‐ology of cholestatic liver disease. Hepatology 2001, 33: 758-759. PMID: 11230758, DOI: 10.1053/jhep.2001.23034.
- Cho W, Mennone A, Boyer J. Isolation of functional polarized bile duct units from mouse liver. AJP Gastrointestinal And Liver Physiology 2001, 280: g241-g246. PMID: 11208546, DOI: 10.1152/ajpgi.2001.280.2.g241.
- Mennone A, Biemesderfer D, Negoianu D, Yang C, Abbiati T, Schultheis P, Shull G, Aronson P, Boyer J. Role of sodium/hydrogen exchanger isoform NHE3 in fluid secretion and absorption in mouse and rat cholangiocytes. AJP Gastrointestinal And Liver Physiology 2001, 280: g247-g254. PMID: 11208547, DOI: 10.1152/ajpgi.2001.280.2.g247.
- Schlosser S, Azzaroli F, Dao T, Hingorani R, Crispe I, Boyer J. Induction of murine hepatocyte death by membrane‐bound CD95 (Fas/APO‐1)‐ligand: Characterization of an in Vitro system. Hepatology 2000, 32: 779-785. PMID: 11003622, DOI: 10.1053/jhep.2000.18422.
- Gigliozzi A, Fraioli F, Sundaram P, Lee J, Mennone A, Alvaro D, Boyer J. Molecular identification and functional characterization of Mdr1a in rat cholangiocytes. Gastroenterology 2000, 119: 1113-1122. PMID: 11040198, DOI: 10.1053/gast.2000.18156.
- Dranoff J, O'Neill A, Franco A, Cai S, Connolly G, Ballatori N, Boyer J, Nathanson M. A Primitive ATP Receptor from the Little Skate Raja erinacea *. Journal Of Biological Chemistry 2000, 275: 30701-30706. PMID: 10900200, DOI: 10.1074/jbc.m003366200.
- Rebbeor J, Connolly G, Henson J, Boyer J, Ballatori N. ATP-dependent GSH and glutathioneS-conjugate transport in skate liver: role of an Mrp functional homologue. AJP Gastrointestinal And Liver Physiology 2000, 279: g417-g425. PMID: 10915652, DOI: 10.1152/ajpgi.2000.279.2.g417.
- Trauner M, Boyer J. Cholestatic syndromes. Current Opinion In Gastroenterology 2000, 16: 239-250. PMID: 17023881, DOI: 10.1097/00001574-200005000-00006.
- Dranoff J, O’Neill A, Cai S, Franco A, Connelly G, Ballatori N, Boyer J, Nathanson M. Molecular identification of a primitive P2Y ATP receptor in liver from the little skate Raja erinacea. Gastroenterology 2000, 118: a911. DOI: 10.1016/s0016-5085(00)85777-7.
- Ballatori N, Rebbeor J, Connolly G, Seward D, Lenth B, Henson J, Sundaram P, Boyer J. Bile salt excretion in skate liver is mediated by a functional analog of Bsep/Spgp, the bile salt export pump. AJP Gastrointestinal And Liver Physiology 2000, 278: g57-g63. PMID: 10644562, DOI: 10.1152/ajpgi.2000.278.1.g57.
- Lee J, Trauner M, Soroka C, Stieger B, Meier P, Boyer J. Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology 2000, 118: 163-172. PMID: 10611165, DOI: 10.1016/s0016-5085(00)70425-2.
- Ballatori N, Connolly G, Boyer J. Elasmobranch hepatocytes. 2000, 37-47. DOI: 10.1007/978-94-017-3345-8_5.
- Runnegar M, Seward D, Ballatori N, Crawford J, Boyer J. Hepatic Toxicity and Persistence of ser/thr Protein Phosphatase Inhibition by Microcystin in the Little Skate Raja erinacea. Toxicology And Applied Pharmacology 1999, 161: 40-49. PMID: 10558922, DOI: 10.1006/taap.1999.8783.
- Ballatori N, Hager D, Nundy S, Miller D, Boyer J. Carrier-mediated uptake of lucifer yellow in skate and rat hepatocytes: a fluid-phase marker revisited. American Journal Of Physiology 1999, 277: g896-g904. PMID: 10516157, DOI: 10.1152/ajpgi.1999.277.4.g896.
- Soroka C, Pate M, Boyer J. Canalicular Export Pumps Traffic with Polymeric Immunoglobulin A Receptor on the Same Microtubule-associated Vesicle in Rat Liver*. Journal Of Biological Chemistry 1999, 274: 26416-26424. PMID: 10473600, DOI: 10.1074/jbc.274.37.26416.
- Combes B, Markin R, Wheeler D, Rubin R, West A, Mills A, Eigenbrodt E, Maddrey W, Munoz S, Garcia‐Tsao G, Bonner G, Boyer J, Luketic V, Shiffman M, Peters M, White H, Zetterman R, Carithers R. The effect of ursodeoxycholic acid on the florid duct lesion of primary biliary cirrhosis. Hepatology 1999, 30: 602-605. PMID: 10462363, PMCID: PMC3935822, DOI: 10.1002/hep.510300315.
- Cho W, Boyer J. Vasoactive intestinal polypeptide is a potent regulator of bile secretion from rat cholangiocytes. Gastroenterology 1999, 117: 420-428. PMID: 10419925, DOI: 10.1053/gast.1999.0029900420.
- Trauner M, Meier P, Boyer J. Molecular regulation of hepatocellular transport systems in cholestasis. Journal Of Hepatology 1999, 31: 165-178. PMID: 10424299, DOI: 10.1016/s0168-8278(99)80179-2.
- Combes B, Carithers R, Maddrey W, Munoz S, Garcia‐Tsao G, Bonner G, Boyer J, Luketic V, Shiffman M, Peters M, White H, Zetterman R, Risser R, Rossi S, Hofmann A. Biliary bile acids in primary biliary cirrhosis: Effect of ursodeoxycholic acid. Hepatology 1999, 29: 1649-1654. PMID: 10347103, PMCID: PMC4004074, DOI: 10.1002/hep.510290618.
- Cho W, Boyer J. Characterization of ion transport mechanisms involved in bombesin-stimulated biliary secretion in rat cholangiocytes. Journal Of Hepatology 1999, 30: 1045-1051. PMID: 10406182, DOI: 10.1016/s0168-8278(99)80258-x.
- Trauner M, Boyer J. Cholestatic syndromes. Current Opinion In Gastroenterology 1999, 15: 217-228. PMID: 17023948, DOI: 10.1097/00001574-199905000-00006.
- Hayes J, Soroka C, Rios‐Velez L, Boyer J. Hepatic sequestration and modulation of the canalicular transport of the organic cation, daunorubicin, in the rat. Hepatology 1999, 29: 483-493. PMID: 9918926, DOI: 10.1002/hep.510290216.
- Beuers U, Probst I, Soroka C, Boyer J, Kullak‐Ublick G, Paumgartner G. Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes. Hepatology 1999, 29: 477-482. PMID: 9918925, DOI: 10.1002/hep.510290227.
- Trauner M, Mennone A, Gigliozzi A, Fraioli F, Boyer J. Nitric oxide and guanosine 3′,5′‐cyclic monophosphate stimulate bile secretion in isolated rat hepatocyte couplets, but not in isolated bile duct units. Hepatology 1998, 28: 1621-1628. PMID: 9828227, DOI: 10.1002/hep.510280623.
- Beuers U, Boyer J, Paumgartner G. Ursodeoxycholic acid in cholestasis: Potential mechanisms of action and therapeutic applications. Hepatology 1998, 28: 1449-1453. PMID: 9828205, DOI: 10.1002/hep.510280601.
- Wolkoff A, Suchy F, Moseley R, Meier P, Gollan J, Freimer N, Fitz J, Boyer J, Berk P, Scharschmidt B. Advances in hepatic transport: Molecular mechanisms, genetic disorders, and treatment. A summary of the 1998 AASLD single topic conference. Hepatology 1998, 28: 1713-1719. PMID: 9828241, DOI: 10.1002/hep.510280637.
- Zheng T, Schlosser S, Dao T, Hingorani R, Crispe I, Boyer J, Flavell R. Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 13618-13623. PMID: 9811849, PMCID: PMC24868, DOI: 10.1073/pnas.95.23.13618.
- Cho W, Mennone A, Boyer J. Intracellular pH regulation in bombesin-stimulated secretion in isolated bile duct units from rat liver. American Journal Of Physiology 1998, 275: g1028-g1036. PMID: 9815033, DOI: 10.1152/ajpgi.1998.275.5.g1028.
- Epstein F, Trauner M, Meier P, Boyer J. Molecular Pathogenesis of Cholestasis. New England Journal Of Medicine 1998, 339: 1217-1227. PMID: 9780343, DOI: 10.1056/nejm199810223391707.
- Arrese M, Trauner M, Ananthanarayanan M, Boyer J, Suchy F. Maternal cholestasis does not affect the ontogenic pattern of expression of the Na+/Taurocholate cotransporting polypeptide (ntcp) in the fetal and neonatal rat liver. Hepatology 1998, 28: 789-795. PMID: 9731574, DOI: 10.1002/hep.510280328.
- Crawford J, Boyer J. Clinicopathology conferences: Inflammation‐induced cholestasis. Hepatology 1998, 28: 253-260. PMID: 9657120, DOI: 10.1002/hep.510280133.
- Trauner M, Arrese M, Lee H, Boyer J, Karpen S. Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors. Journal Of Clinical Investigation 1998, 101: 2092-2100. PMID: 9593765, PMCID: PMC508797, DOI: 10.1172/jci1680.
- Koeppel T, Trauner M, Albert M, Arrese M, Rios-Velez L, Boyer J. Role of glutathione in hepatic bile formation during reperfusion after cold ischemia of the rat liver. Journal Of Hepatology 1998, 28: 812-819. PMID: 9625316, DOI: 10.1016/s0168-8278(98)80231-6.
- Roelofsen H, Soroka C, Keppler D, Boyer J. Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets. Journal Of Cell Science 1998, 111: 1137-1145. PMID: 9512509, DOI: 10.1242/jcs.111.8.1137.
- Ballatori N, Boyer J. ATP regulation of a swelling‐activated osmolyte channel in skate hepatocytes. Journal Of Experimental Zoology 1997, 279: 471-475. PMID: 9392868, DOI: 10.1002/(sici)1097-010x(19971201)279:5<471::aid-jez9>3.0.co;2-l.
- Fricker G, Wössner R, Drewe J, Fricker R, Boyer J. Enterohepatic circulation of scymnol sulfate in an elasmobranch, the little skate (Raja erinacea). American Journal Of Physiology 1997, 273: g1023-g1030. PMID: 9374698, DOI: 10.1152/ajpgi.1997.273.5.g1023.
- Koeppel T, Trauner M, Baas J, Thies J, Schlosser S, Post S, Gebhard M, Herfarth C, Boyer J, Otto G. Extrahepatic biliary obstruction impairs microvascular perfusion and increases leukocyte adhesion in rat liver. Hepatology 1997, 26: 1085-1091. PMID: 9362346, DOI: 10.1002/hep.510260501.
- Trauner M, Arrese M, Soroka C, Ananthanarayanan M, Koeppel T, Schlosser S, Suchy F, Keppler D, Boyer J. The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology 1997, 113: 255-264. PMID: 9207286, DOI: 10.1016/s0016-5085(97)70103-3.
- Cho W, Mennone A, Rydberg, Boyer J. Bombesin stimulates bicarbonate secretion from rat cholangiocytes: Implications for neural regulation of bile secretion. Gastroenterology 1997, 113: 311-321. PMID: 9207292, DOI: 10.1016/s0016-5085(97)70109-4.
- Gartung C, Schuele S, Schlosser S, Boyer J. Expression of the rat liver Na+/taurocholate cotransporter is regulated in vivo by retention of biliary constituents but not their depletion. Hepatology 1997, 25: 284-290. PMID: 9021935, DOI: 10.1002/hep.510250205.
- Setchell K, Rodrigues C, Clerici C, Solinas A, Morelli A, Gartung C, Boyer J. Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei. Gastroenterology 1997, 112: 226-235. PMID: 8978363, DOI: 10.1016/s0016-5085(97)70239-7.
- Ballatori N, Boyer J. Disruption of Cell Volume Regulation by Mercuric Chloride Is Mediated by an Increase in Sodium Permeability and Inhibition of an Osmolyte Channel in Skate Hepatocytes. Toxicology And Applied Pharmacology 1996, 140: 404-410. PMID: 8887458, DOI: 10.1006/taap.1996.0237.
- Boyer J. Bile secretion-models, mechanisms, and malfunctions. A perspective on the development of modern cellular and molecular concepts of bile secretion and cholestasis. Journal Of Gastroenterology 1996, 31: 475-481. PMID: 8726846, DOI: 10.1007/bf02355044.
- Miller D, Fricker G, Schramm U, Henson J, Hager D, Nundy S, Ballatori N, Boyer J. Active microtubule-dependent secretion of a fluorescent bile salt derivative in skate hepatocyte clusters. American Journal Of Physiology 1996, 270: g887-g896. PMID: 8764193, DOI: 10.1152/ajpgi.1996.270.6.g887.
- Strazzabosco M, Boyer J. Regulation of intracellular pH in the hepatocyte Mechanisms and physiological implications. Journal Of Hepatology 1996, 24: 631-644. PMID: 8773922, DOI: 10.1016/s0168-8278(96)80153-x.
- Beuers U, Throckmorton D, Anderson, Isales C, Thasler W, Kullak-Ublick G, Sauter G, Koebe H, Paumgartner G, Boyer J. Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes. Gastroenterology 1996, 110: 1553-1563. PMID: 8613063, DOI: 10.1053/gast.1996.v110.pm8613063.
- Boyer J. Bile duct epithelium: frontiers in transport physiology. American Journal Of Physiology 1996, 270: g1-g5. PMID: 8772494, DOI: 10.1152/ajpgi.1996.270.1.g1.
- Jackson P, Churchwell K, Ballatori N, Boyer J, Strange K. Swelling-activated anion conductance in skate hepatocytes: regulation by cell Cl- and ATP. American Journal Of Physiology 1996, 270: c57-c66. PMID: 8772430, DOI: 10.1152/ajpcell.1996.270.1.c57.
- Gartung C, Ananthanarayanan M, Rahman M, Schuele S, Nundy S, Soroka C, Stolz A, Suchy F, Boyer J. Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis. Gastroenterology 1996, 110: 199-209. PMID: 8536857, DOI: 10.1053/gast.1996.v110.pm8536857.
- Combes B, Carithers R, Maddrey W, Lin D, McDonald M, Wheeler D, Eigenbrodt E, Muñoz S, Rubin R, Garcia-Tsao G, Bonner G, West A, Boyer J, Luketic V, Shiffman M, Mills A, Peters M, White H, Zetterman R, Rossi S, Hofmann A, Markin R. A randomized double-blind, placebo-controlled trial ursodeoxycholic acid in primary biliary cirrhosis. European Journal Of Gastroenterology & Hepatology 1995, 7: 1132. DOI: 10.1097/00042737-199511000-00024.
- Boyer J, Soroka C. Vesicle targeting to the apical domain regulates bile excretory function in isolated rat hepatocyte couplets. Gastroenterology 1995, 109: 1600-1611. PMID: 7557144, DOI: 10.1016/0016-5085(95)90649-5.
- Nundy S, Hager D, Kaljuvee J, Rexroad J, Ballatori N, Miller D, Boyer J. Carrier mediated uptake of Lucifer Yellow in liver of Raja erinacea, the small skate and the rat: A fluid phase marker revisited. Hepatology 1995, 22: a309. DOI: 10.1016/0270-9139(95)94958-5.
- Ballatori N, Truong A, Jackson P, Strange K, Boyer J. ATP depletion and inactivation of an ATP-sensitive taurine channel by classic ion channel blockers. Molecular Pharmacology 1995, 48: 472-6. PMID: 7565627.
- Combes B, Carithers R, Maddrey W, Lin D, Mcdonald M, Wheeler D, Eigenbrodt E, Muñoz S, Rubin R, Garcia-tsao G, Bonner G, West A, Boyer J, Luketic V, Shiffman M, Mills A, Peters M, White H, Zetterman R, Rossi S, Hofmann A, Markin R. A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid in primary biliary cirrhosis. Hepatology 1995, 22: 759-766. DOI: 10.1016/0270-9139(95)90294-5.
- Combes B, Carithers R, Maddrey W, Lin D, McDonald M, Wheeler D, Eigenbrodt E, Muñoz S, Rubin R, Garcia‐Tsao G, Bonner G, West A, Boyer J, Luketic V, Shiffman M, Mills A, Peters M, White H, Zetterman R, Rossi S, Hofmann A, Markin R. A randomized, double‐blind, placebo‐controlled trial of ursodeoxycholic acid in primary biliary cirrhosis. Hepatology 1995, 22: 759-766. PMID: 7657280, DOI: 10.1002/hep.1840220311.
- Mennone A, Alvaro D, Cho W, Boyer J. Isolation of small polarized bile duct units. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 6527-6531. PMID: 7541542, PMCID: PMC41551, DOI: 10.1073/pnas.92.14.6527.
- Felig D, Brusilow S, Boyer J. Hyperammonemic coma due to parenteral nutrition in a woman with heterozygous ornithine transcarbamylase deficiency. Gastroenterology 1995, 109: 282-284. PMID: 7797025, DOI: 10.1016/0016-5085(95)90295-3.
- Henson J, Capuano S, Nesbitt D, Hager D, Nundy S, Miller D, Ballatori N, Boyer J. Cytoskeletal organization in clusters of isolated polarized skate hepatocytes: Structural and functional evidence for microtubule‐dependent transcytosis. Journal Of Experimental Zoology 1995, 271: 273-284. PMID: 7722471, DOI: 10.1002/jez.1402710405.
- MAHL T, SHOCKCOR W, BOYER J. Primary Biliary Cirrhosis. Survey Of Anesthesiology 1995, 39: 61. DOI: 10.1097/00132586-199502000-00074.
- Jacquemin E, Hagenbuch B, Wolkoff A, Meier P, Boyer J. Expression of sodium-independent organic anion uptake systems of skate liver in Xenopus laevis oocytes. American Journal Of Physiology 1995, 268: g18-g23. PMID: 7840202, DOI: 10.1152/ajpgi.1995.268.1.g18.
- Bruck R, Nathanson M, Roelofsen H, Boyer J. Effects of protein kinase C and cytosolic Ca2+ on exocytosis in the isolated perfused rat liver. Hepatology 1994, 20: 1032-1040. PMID: 7927205, DOI: 10.1002/hep.1840200436.
- Ananthanarayanan M, Ng O, Boyer J, Suchy F. Characterization of cloned rat liver Na(+)-bile acid cotransporter using peptide and fusion protein antibodies. American Journal Of Physiology 1994, 267: g637-g643. PMID: 7943329, DOI: 10.1152/ajpgi.1994.267.4.g637.
- Ballatori N, Simmons T, Boyer J. A volume-activated taurine channel in skate hepatocytes: membrane polarity and role of intracellular ATP. American Journal Of Physiology 1994, 267: g285-g291. PMID: 7521136, DOI: 10.1152/ajpgi.1994.267.2.g285.
- Fricker G, Dubost V, Finsterwald K, Boyer J. Characteristics of bile salt uptake into skate hepatocytes. Biochemical Journal 1994, 299: 665-670. PMID: 8192655, PMCID: PMC1138072, DOI: 10.1042/bj2990665.
- Boyer J, Ng O, Ananthanarayanan M, Hofmann A, Schteingart C, Hagenbuch B, Stieger B, Meier P. Expression and characterization of a functional rat liver Na+ bile acid cotransport system in COS-7 cells. American Journal Of Physiology 1994, 266: g382-g387. PMID: 8166278, DOI: 10.1152/ajpgi.1994.266.3.g382.
- Benedetti A, Strazzabosco M, Ng O, Boyer J. Regulation of activity and apical targeting of the Cl-/HCO3- exchanger in rat hepatocytes. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 792-796. PMID: 8290601, PMCID: PMC43035, DOI: 10.1073/pnas.91.2.792.
- Mahl T, Shockcor W, Boyer J. Primary biliary cirrhosis: survival of a large cohort of symptomatic and asymptomatic patients followed for 24 years. Journal Of Hepatology 1994, 20: 707-713. PMID: 7930469, DOI: 10.1016/s0168-8278(05)80139-4.
- Blumrich M, Petzinger E, Boyer J. Characterization of bumetanide transport in isolated skate hepatocytes. American Journal Of Physiology 1993, 265: g926-g933. PMID: 8238522, DOI: 10.1152/ajpgi.1993.265.5.g926.
- Alvaro D, Mennone A, Boyer J. Effect of ursodeoxycholic acid on intracellular pH regulation in isolated rat bile duct epithelial cells. American Journal Of Physiology 1993, 265: g783-g791. PMID: 8238362, DOI: 10.1152/ajpgi.1993.265.4.g783.
- Alvaro D, Cho W, Mennone A, Boyer J. Effect of secretion on intracellular pH regulation in isolated rat bile duct epithelial cells. Journal Of Clinical Investigation 1993, 92: 1314-1325. PMID: 8397224, PMCID: PMC288273, DOI: 10.1172/jci116705.
- Bruck R, Benedetti A, Strazzabosco M, Boyer J. Intracellular alkalinization stimulates bile flow and vesicular-mediated exocytosis in IPRL. American Journal Of Physiology 1993, 265: g347-g353. PMID: 8368316, DOI: 10.1152/ajpgi.1993.265.2.g347.
- Beuers U, Nathanson M, Boyer J. Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes. Gastroenterology 1993, 104: 604-612. PMID: 8425704, DOI: 10.1016/0016-5085(93)90433-d.
- Garcia-Tsao G, Boyer J. Outpatient liver biopsy: how safe is it? Annals Of Internal Medicine 1993, 118: 150-3. PMID: 8416312, DOI: 10.7326/0003-4819-118-2-199301150-00013.
- Boyer J, Hagenbuch B, Ananthanarayanan M, Suchy F, Stieger B, Meier P. Phylogenic and ontogenic expression of hepatocellular bile acid transport. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 435-438. PMID: 8421672, PMCID: PMC45677, DOI: 10.1073/pnas.90.2.435.
- Boyer J, Graf J, Meier P. Hepatic Transport Systems Regulating pHi, Cell Volume, and Bile Secretion. Annual Review Of Physiology 1992, 54: 415-438. PMID: 1562181, DOI: 10.1146/annurev.ph.54.030192.002215.
- Hayakawa T, Katagiri K, Hoshino M, Nakai T, Ohiwa T, Kumai T, Miyaji M, Takeuchi T, Corasanti J, Boyer J. Papaverine inhibits transcytotic vesicle transport and lipid excretion into bile in isolated perfused rat liver. Hepatology 1992, 16: 1036-1042. PMID: 1398483, DOI: 10.1002/hep.1840160429.
- Sellinger M, Weinman S, Henderson R, Zweifach A, Boyer J, Graf J. Anion channels in rat liver canalicular plasma membranes reconstituted into planar lipid bilayers. American Journal Of Physiology 1992, 262: g1027-g1032. PMID: 1377450, DOI: 10.1152/ajpgi.1992.262.6.g1027.
- Bruck R, Haddad P, Graf J, Boyer J. Regulatory volume decrease stimulates bile flow, bile acid excretion, and exocytosis in isolated perfused rat liver. American Journal Of Physiology 1992, 262: g806-g812. PMID: 1590390, DOI: 10.1152/ajpgi.1992.262.5.g806.
- Ballatori N, Boyer J. Taurine transport in skate hepatocytes. II. Volume activation, energy, and sulfhydryl dependence. American Journal Of Physiology 1992, 262: g451-g460. PMID: 1550235, DOI: 10.1152/ajpgi.1992.262.3.g451.
- Ballatori N, Boyer J. Taurine transport in skate hepatocytes. I. Uptake and efflux. American Journal Of Physiology 1992, 262: g445-g450. PMID: 1550234, DOI: 10.1152/ajpgi.1992.262.3.g445.
- Boyer J, Shockcor W, Mahl T. The natural history of primary biliary cirrhosis. Transactions Of The American Clinical And Climatological Association 1992, 103: 157-63. PMID: 1413375, PMCID: PMC2376687.
- Nathanson M, Gautam A, Bruck R, Isales C, Boyer J. Effects of Ca2+ agonists on cytosolic Ca2+ in isolated hepatocytes and on bile secretion in the isolated perfused rat liver. Hepatology 1992, 15: 107-116. PMID: 1727785, DOI: 10.1002/hep.1840150119.
- Benedetti A, Strazzabosco M, Corasanti J, Haddad P, Graf J, Boyer J. Cl(-)-HCO3- exchanger in isolated rat hepatocytes: role in regulation of intracellular pH. American Journal Of Physiology 1991, 261: g512-g522. PMID: 1887897, DOI: 10.1152/ajpgi.1991.261.3.g512.
- Nathanson M, Boyer J. Mechanisms and regulation of bile secretion. Hepatology 1991, 14: 551-566. PMID: 1874500, DOI: 10.1002/hep.1840140324.
- Haddad P, Beck J, Boyer J, Graf J. Role of chloride ions in liver cell volume regulation. American Journal Of Physiology 1991, 261: g340-g348. PMID: 1872402, DOI: 10.1152/ajpgi.1991.261.2.g340.
- Strazzabosco M, Boyer J, Crepaldi G. The use of isolated rat hepatocyte couplets, microscopic optical planimetry and quantitative microfluorimetry in hepatobiliary physiology. Cytotechnology 1991, 5: 88-89. PMID: 22358966, DOI: 10.1007/bf00736820.
- Sellinger M, Ballatori N, Boyer J. Mechanism of mercurial inhibition of sodium-coupled alanine uptake in liver plasma membrane vesicles from Raja erinacea. Toxicology And Applied Pharmacology 1991, 107: 369-376. PMID: 1994517, DOI: 10.1016/0041-008x(91)90216-2.
- Strazzabosco M, Sakisaka S, Hayakawa T, Boyer J. Effect of UDCA on intracellular and biliary pH in isolated rat hepatocyte couplets and perfused livers. American Journal Of Physiology 1991, 260: g58-g69. PMID: 1987808, DOI: 10.1152/ajpgi.1991.260.1.g58.
- Hayakawa T, Bruck R, Ng O, Boyer J. DBcAMP stimulates vesicle transport and HRP excretion in isolated perfused rat liver. American Journal Of Physiology 1990, 259: g727-g735. PMID: 2173414, DOI: 10.1152/ajpgi.1990.259.5.g727.
- Hayakawa T, Cheng O, Ma A, Boyer J. Taurocholate stimulates transcytotic vesicular pathways labeled by horseradish peroxidase in the isolated perfused rat liver. Gastroenterology 1990, 99: 216-228. PMID: 2344927, DOI: 10.1016/0016-5085(90)91251-z.
- Graf J, Boyer J. The use of isolated rat hepatocyte couplets in hepatobiliary physiology. Journal Of Hepatology 1990, 10: 387-394. PMID: 2195112, DOI: 10.1016/0168-8278(90)90152-h.
- Simmons T, Moseley R, Boyer J, Ballatori N. Modulation of Na+/alanine cotransport in liver sinusoidal membrane vesicles by internal divalent cations. Biochimica Et Biophysica Acta 1990, 1023: 462-468. PMID: 2110482, DOI: 10.1016/0005-2736(90)90140-j.
- Gleeson D, Corasanti J, Boyer J. Effects of osmotic stresses on isolated rat hepatocytes. II. Modulation of intracellular pH. American Journal Of Physiology 1990, 258: g299-g307. PMID: 2305896, DOI: 10.1152/ajpgi.1990.258.2.g299.
- Corasanti J, Gleeson D, Boyer J. Effects of osmotic stresses on isolated rat hepatocytes. I. Ionic mechanisms of cell volume regulation. American Journal Of Physiology 1990, 258: g290-g298. PMID: 2305895, DOI: 10.1152/ajpgi.1990.258.2.g290.
- Sellinger M, Barrett C, Malle P, Gordon E, Boyer J. Cryptic na+, k+‐atpase activity in rat liver canalicular plasma membranes: Evidence for its basolateral origin. Hepatology 1990, 11: 223-229. PMID: 2155168, DOI: 10.1002/hep.1840110211.
- Boyer J, Meier P. [33] Characterizing mechanisms of hepatic bile acid transport utilizing isolated membrane vesicles. 1990, 192: 517-533. PMID: 2074806, DOI: 10.1016/0076-6879(90)92091-q.
- Boyer J, Phillips J, Graf J. [32] Preparation and specific applications of isolated hepatocyte couplets. 1990, 192: 501-516. PMID: 1963665, DOI: 10.1016/0076-6879(90)92090-z.
- Meier P, Boyer J. [34] Preparation of basolateral (sinusoidal) and canalicular plasma membrane vesicles for the study of hepatic transport processes. 1990, 192: 534-545. PMID: 1963666, DOI: 10.1016/0076-6879(90)92092-r.
- CORASANTI J, GLEESON D, BOYER J. Ionic Mechanisms of Cell Volume Regulation in Isolated Rat Hepatocytes. Annals Of The New York Academy Of Sciences 1989, 574: 385-387. DOI: 10.1111/j.1749-6632.1989.tb25172.x.
- SELLINGER M, WEINMAN S, HENDERSON R, ZWEIFACH A, BOYER J, GRAF J. Properties of an Anion Channel in Rat Liver Canalicular Membranes. Annals Of The New York Academy Of Sciences 1989, 574: 57-59. DOI: 10.1111/j.1749-6632.1989.tb25134.x.
- Gleeson D, Smith N, Boyer J. Bicarbonate-dependent and -independent intracellular pH regulatory mechanisms in rat hepatocytes. Evidence for Na+-HCO3- cotransport. Journal Of Clinical Investigation 1989, 84: 312-321. PMID: 2544626, PMCID: PMC303984, DOI: 10.1172/jci114156.
- Corasanti J, Smith N, Gordon E, Boyer J. Protein kinase C agonists inhibit bile secretion independently of effects on the microcirculation in the isolated perfused rat liver. Hepatology 1989, 10: 8-13. PMID: 2737605, DOI: 10.1002/hep.1840100103.
- Henderson R, Graf J, Boyer J. Inward-rectifying potassium channels in rat hepatocytes. American Journal Of Physiology 1989, 256: g1028-g1035. PMID: 2735409, DOI: 10.1152/ajpgi.1989.256.6.g1028.
- Weinman S, Graf J, Boyer J. Voltage-driven, taurocholate-dependent secretion in isolated hepatocyte couplets. American Journal Of Physiology 1989, 256: g826-g832. PMID: 2719107, DOI: 10.1152/ajpgi.1989.256.5.g826.
- Anderson J, Glade J, Stevenson B, Boyer J, Mooseker M. Hepatic immunohistochemical localization of the tight junction protein ZO-1 in rat models of cholestasis. American Journal Of Pathology 1989, 134: 1055-62. PMID: 2719075, PMCID: PMC1879891.
- Ballatori N, Truong A, K. A, Boyer J. Determinants of glutathione efflux and biliary GSH/GSSG ratio in perfused rat liver. American Journal Of Physiology 1989, 256: g482-g490. PMID: 2564253, DOI: 10.1152/ajpgi.1989.256.3.g482.
- Gautam A, Ng O, Strazzabosco M, Boyer J. Quantitative assessment of canalicular bile formation in isolated hepatocyte couplets using microscopic optical planimetry. Journal Of Clinical Investigation 1989, 83: 565-573. PMID: 2913052, PMCID: PMC303716, DOI: 10.1172/jci113919.
- Sellinger M, Weinman S, Boyer J, Graf J. Ion channels in canalicular rat liver plasma membranes. Journal Of Hepatology 1989, 9: s84. DOI: 10.1016/0168-8278(89)90344-9.
- Ballatori N, Wondergem R, Boyer J. Effect of l-alanine on membrane potential, potassium (86Rb) permeability and cell volume in hepatocytes from Raja erinacea. Biochimica Et Biophysica Acta 1988, 946: 261-269. PMID: 3207743, DOI: 10.1016/0005-2736(88)90401-4.
- Boyer J, Gautam A, Graf J. Mechanisms of Bile Secretion: lnsights from the Isolated Rat Hepatocyte Couplet. Seminars In Liver Disease 1988, 8: 308-316. PMID: 2850606, DOI: 10.1055/s-2008-1040552.
- Sakisaka S, Ng O, Boyer J. Tubulovesicular Transcytotic Pathway in Isolated Rat Hepatocyte Couplets in Culture Effect of Colchicine and Taurocholate. Gastroenterology 1988, 95: 793-804. PMID: 3396824, DOI: 10.1016/s0016-5085(88)80030-1.
- Ballatori N, Shi C, Boyer J. Altered plasma membrane ion permeability in mercury-induced cell injury: Studies in hepatocytes of elasmobranch Raja erinacea. Toxicology And Applied Pharmacology 1988, 95: 279-291. PMID: 2844008, DOI: 10.1016/0041-008x(88)90164-0.
- Henderson R, Krumpholz B, Boyer J, Graf J. Effect of intracellular pH on potassium conductance in liver. Pflügers Archiv - European Journal Of Physiology 1988, 412: 334-335. PMID: 3186436, DOI: 10.1007/bf00582518.
- Ballatori N, Boyer J. Characteristics of L-alanine uptake in freshly isolated hepatocytes of elasmobranch Raja erinacea. American Journal Of Physiology 1988, 254: r801-r808. PMID: 3364608, DOI: 10.1152/ajpregu.1988.254.5.r801.
- Ballatori N, Jacob R, Barrett C, Boyer J. Biliary catabolism of glutathione and differential reabsorption of its amino acid constituents. American Journal Of Physiology 1988, 254: g1-g7. PMID: 2892423, DOI: 10.1152/ajpgi.1988.254.1.g1.
- Fricker G, Hugentobler G, Meier P, Kurz G, Boyer J. Identification of a single sinusoidal bile salt uptake system in skate liver. American Journal Of Physiology 1987, 253: g816-g822. PMID: 3425718, DOI: 10.1152/ajpgi.1987.253.6.g816.
- Hugentobler G, Fricker G, Boyer J, Meier P. Anion transport in basolateral (sinusoidal) liver plasma-membrane vesicles of the little skate (Raja erinacea). Biochemical Journal 1987, 247: 589-595. PMID: 3426551, PMCID: PMC1148453, DOI: 10.1042/bj2470589.
- Graf J, Henderson R, Krumpholz B, Boyer J. Cell membrane and transepithelial voltages and resistances in isolated rat hepatocyte couplets. The Journal Of Membrane Biology 1987, 95: 241-254. PMID: 3585979, DOI: 10.1007/bf01869486.
- Moseley R, Ballatori N, Smith D, Boyer J. Ursodeoxycholate stimulates Na+-H+ exchange in rat liver basolateral plasma membrane vesicles. Journal Of Clinical Investigation 1987, 80: 684-690. PMID: 3040805, PMCID: PMC442291, DOI: 10.1172/jci113122.
- Helzberg J, Petersen J, Boyer J. Improved survival with primary sclerosing cholangitis A review of clinicopathologic features and comparison of symptomatic and asymptomatic patients. Gastroenterology 1987, 92: 1869-1875. PMID: 3569762, DOI: 10.1016/0016-5085(87)90618-4.
- Smith D, Grossbard M, Gordon E, Boyer J. Taurocholate uptake by isolated skate hepatocytes: effect of albumin. American Journal Of Physiology 1987, 252: g479-g484. PMID: 3565567, DOI: 10.1152/ajpgi.1987.252.4.g479.
- Meier P, Meier-Abt A, Boyer J. Properties of the canalicular bile acid transport system in rat liver. Biochemical Journal 1987, 242: 465-469. PMID: 3593261, PMCID: PMC1147728, DOI: 10.1042/bj2420465.
- Gautam A, Ng O, Boyer J. Isolated rat hepatocyte couplets in short‐term culture: Structural characteristics and plasma membrane reorganization. Hepatology 1987, 7: 216-223. PMID: 3557300, DOI: 10.1002/hep.1840070203.
- Smith D, Grossbard M, Gordon E, Boyer J. Isolation and characterization of a polarized isolated hepatocyte preparation in the skate Raja erinacea. Journal Of Experimental Zoology 1987, 241: 291-296. PMID: 3585270, DOI: 10.1002/jez.1402410303.
- Witzleben C, Boyer J, Ng O. Manganese-bilirubin cholestasis. Further studies in pathogenesis. Laboratory Investigation 1987, 56: 151-4. PMID: 3807313.
- Henderson R, Graf J, Boyer J. Na-H exchange regulates intracellular pH in isolated rat hepatocyte couplets. American Journal Of Physiology 1987, 252: g109-g113. PMID: 3028151, DOI: 10.1152/ajpgi.1987.252.1.g109.
- Grossbard M, Boyer J, Gordon E. The excretion pattern of biliverdin and bilirubin in bile of the small skate (Raja erinacea). Journal Of Comparative Physiology B 1987, 157: 61-66. PMID: 3571566, DOI: 10.1007/bf00702729.
- Boyer J. Mechanisms of Bile Secretion and Hepatic Transport. 1987, 225-252. DOI: 10.1007/978-1-4684-5404-8_12.
- Mills P, Meier P, Smith D, Ballatori N, Boyer J, Gordon E. The effect of changes in the fluid state of rat liver plasma membrane on the transport of taurocholate. Hepatology 1987, 7: 61-66. PMID: 3804206, DOI: 10.1002/hep.1840070114.
- Lorenzini I, Sakisaka S, Meier P, Boyer J. Demonstration of a Transcellular Vesicle Pathway for Biliary Excretion of Inulin in Rat Liver. Gastroenterology 1986, 91: 1278-1288. PMID: 3758619, DOI: 10.1016/s0016-5085(86)80028-2.
- Ballatori N, Boyer J. Slow biliary elimination of methyl mercury in the marine elasmobranchs, Raja erinacea and Squalus acanthias. Toxicology And Applied Pharmacology 1986, 85: 407-415. PMID: 3764924, DOI: 10.1016/0041-008x(86)90348-0.
- Ballatori N, Jacob R, Boyer J. Intrabiliary glutathione hydrolysis. A source of glutamate in bile. Journal Of Biological Chemistry 1986, 261: 7860-7865. PMID: 2872220, DOI: 10.1016/s0021-9258(19)57482-8.
- Ballatori N, Moseley R, Boyer J. Sodium gradient-dependent L-glutamate transport is localized to the canalicular domain of liver plasma membranes. Studies in rat liver sinusoidal and canalicular membrane vesicles. Journal Of Biological Chemistry 1986, 261: 6216-6221. PMID: 2871024, DOI: 10.1016/s0021-9258(19)84550-7.
- Boyer J. Mechanisms of Bile Secretion and Hepatic Transport. 1986, 609-636. DOI: 10.1007/978-1-4613-2097-5_35.
- Beswick D, Klatskin G, Boyer J. Asymptomatic primary biliary cirrhosis A progress report on long-term follow-up and natural history. Gastroenterology 1985, 89: 267-271. PMID: 4007417, DOI: 10.1016/0016-5085(85)90325-7.
- Meier P, Knickelbein R, Moseley R, Dobbins J, Boyer J. Evidence for carrier-mediated chloride/bicarbonate exchange in canalicular rat liver plasma membrane vesicles. Journal Of Clinical Investigation 1985, 75: 1256-1263. PMID: 2985654, PMCID: PMC425453, DOI: 10.1172/jci111824.
- Boyer J, Ng O, Gautam A. Formation of canalicular spaces in isolated rat hepatocyte couplets. Proceedings Of The Association Of American Physicians 1985, 98: 21-9. PMID: 2430357.
- Moseley R, Boyer J. Mechanisms of Electrolyte Transport in the Liver Their Functional Significance. Seminars In Liver Disease 1985, 5: 122-135. PMID: 3161181, DOI: 10.1055/s-2008-1063917.
- Mills P, Meier P, Boyer J, Gordon E. The effect of ethanol and calcium on fluid state of plasma membranes of rat hepatocytes. Alcohol 1985, 2: 153-156. PMID: 4015830, DOI: 10.1016/0741-8329(85)90034-5.
- Blitzer B, Boyer J. Localization of Na+,K+-ATPase on the Hepatocyte Plasma Membrane. Gastroenterology 1984, 87: 1206-1207. PMID: 6090261, DOI: 10.1016/s0016-5085(84)80097-9.
- Graf J, Gautam A, Boyer J. Isolated rat hepatocyte couplets: a primary secretory unit for electrophysiologic studies of bile secretory function. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 6516-6520. PMID: 6149546, PMCID: PMC391955, DOI: 10.1073/pnas.81.20.6516.
- Meier P, St Meier-Abt A, Barrett C, Boyer J. Mechanisms of taurocholate transport in canalicular and basolateral rat liver plasma membrane vesicles. Evidence for an electrogenic canalicular organic anion carrier. Journal Of Biological Chemistry 1984, 259: 10614-10622. PMID: 6469975, DOI: 10.1016/s0021-9258(18)91006-9.
- Gordon E, Meier P, Goresky C, Boyer J. Mechanism and subcellular site of bilirubin diglucuronide formation in rat liver. Journal Of Biological Chemistry 1984, 259: 5500-5506. PMID: 6715357, DOI: 10.1016/s0021-9258(18)91040-9.
- Weisiger R, Zacks C, Smith N, Boyer J. Effect of Albumin Binding on Extraction of Sulfobromophthalein by Perfused Elasmobranch Liver: Evidence for Dissociation‐Limited Uptake. Hepatology 1984, 4: 492-501. PMID: 6724517, DOI: 10.1002/hep.1840040323.
- Meier P, Sztul E, Reuben A, Boyer J. Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liver. Journal Of Cell Biology 1984, 98: 991-1000. PMID: 6699096, PMCID: PMC2113129, DOI: 10.1083/jcb.98.3.991.
- Beswick D, Boyer J. Primary Biliary Cirrhosis. Hepatology 1984, 4: 29s-32s. PMID: 6363257, DOI: 10.1002/hep.1840040710.
- Primor N, Zadunaisky J, Murdaugh H, Boyer J, Forrest J. Pardaxin increases solute permeability of gills and rectal gland in the dogfish shark (Squalus acanthias). Comparative Biochemistry And Physiology Part C Toxicology & Pharmacology 1984, 78: 483-490. PMID: 6149101, DOI: 10.1016/0742-8413(84)90119-1.
- Duffy M, Blitzer B, Boyer J. Direct determination of the driving forces for taurocholate uptake into rat liver plasma membrane vesicles. Journal Of Clinical Investigation 1983, 72: 1470-1481. PMID: 6630516, PMCID: PMC370431, DOI: 10.1172/jci111103.
- Easter D, Wade J, Boyer J. Structural integrity of hepatocyte tight junctions. Journal Of Cell Biology 1983, 96: 745-749. PMID: 6833382, PMCID: PMC2112395, DOI: 10.1083/jcb.96.3.745.
- Roll J, Boyer J, Barry D, Klatskin G. The Prognostic Importance of Clinical and Histologic Features in Asymptomatic and Symptomatic Primary Biliary Cirrhosis. New England Journal Of Medicine 1983, 308: 1-7. PMID: 6847917, DOI: 10.1056/nejm198301063080101.
- Boyer J, Allen R, Ng O. Biochemical Separation of Na+, K+‐ATPase from a “Purified” Light Density, “Canalicular”‐Enriched Plasma Membrane Fraction from Rat Liver. Hepatology 1983, 3: 18-28. PMID: 6130040, DOI: 10.1002/hep.1840030103.
- Reuben A, Howell K, Boyer J. Effects of taurocholate on the size of mixed lipid micelles and their associations with pigment and proteins in rat bile. Journal Of Lipid Research 1982, 23: 1039-1052. PMID: 7142812, DOI: 10.1016/s0022-2275(20)38077-9.
- Tavoloni N, Reed J, Boyer J. Effect of Chlorpromazine on Hepatic Clearance and Excretion of Bile Acids by the Isolated Perfused Rat Liver 1. Experimental Biology And Medicine 1982, 170: 486-492. PMID: 7122478, DOI: 10.3181/00379727-170-41463.
- Blitzer B, Boyer J. Reply. Gastroenterology 1982, 83: 160. DOI: 10.1016/s0016-5085(82)80320-x.
- Blitzer B, Boyer J. Reply. Gastroenterology 1982, 83: 161. DOI: 10.1016/s0016-5085(82)80322-3.
- Blitzer B, Ratoosh S, Donovan C, Boyer J. Effects of inhibitors of Na+-coupled ion transport on bile acid uptake by isolated rat hepatocytes. American Journal Of Physiology 1982, 243: g48-g53. PMID: 6283917, DOI: 10.1152/ajpgi.1982.243.1.g48.
- Forrest J, Boyer J, Ardito T, Murdaugh H, Wade J. Structure of tight junctions during Cl secretion in the perfused rectal gland of the dogfish shark. American Journal Of Physiology 1982, 242: c388-c392. PMID: 7081428, DOI: 10.1152/ajpcell.1982.242.5.c388.
- Reed J, Smith N, Boyer J. Determinants of biliary secretion in isolated perfused skate liver. American Journal Of Physiology 1982, 242: g319-g325. PMID: 7065254, DOI: 10.1152/ajpgi.1982.242.4.g319.
- Reed J, Smith N, Boyer J. Hemodynamic effects on oxygen consumption and bile flow in isolated skate liver. American Journal Of Physiology 1982, 242: g313-g318. PMID: 7065253, DOI: 10.1152/ajpgi.1982.242.4.g313.
- Blitzer B, Boyer J. Cellular mechanisms of bile formation. Gastroenterology 1982, 82: 346-357. PMID: 6274732, DOI: 10.1016/0016-5085(82)90027-0.
- Smith N, Boyer J. Permeability characteristics of bile duct in the rat. American Journal Of Physiology 1982, 242: g52-g57. PMID: 7058899, DOI: 10.1152/ajpgi.1982.242.1.g52.
- Lagarde S, Elias E, Wade J, Boyer J. Structural heterogeneity of hepatocyte “tight” junctions: A quantitative analysis. Hepatology 1981, 1: 193-203. PMID: 7286900, DOI: 10.1002/hep.1840010302.
- Haines N, Baker A, Boyer J, Glagov S, Schneir H, Jaspan J, Ferguson D. Prognostic indicators of hepatic injury following jejunoileal bypass performed for refractory obesity: A prospective study. Hepatology 1981, 1: 161-167. PMID: 7286895, DOI: 10.1002/hep.1840010212.
- Schneider J, Baker A, Haines N, Hatfield G, Boyer J. Aminopyrine n-Demethylation: A Prognostic test of liver function in patients with alcoholic liver disease. Gastroenterology 1980, 79: 1145-1150. PMID: 6777231, DOI: 10.1016/0016-5085(80)90906-3.
- Tavoloni N, Boyer J. Relationship between hepatic metabolism of chlorpromazine and cholestatic effects in the isolated perfused rat liver. Journal Of Pharmacology And Experimental Therapeutics 1980, 214: 269-74. PMID: 7391977.
- Reed J, Meredith S, Nemchausky B, Rosenberg I, Boyer J. Bone disease in primary biliary cirrhosis: Reversal of osteomalacia with oral 25-hydroxyvitamin D. Gastroenterology 1980, 78: 512-517. PMID: 7351289, DOI: 10.1016/0016-5085(80)90865-3.
- Elias E, Boyer J. Chlorpromazine and Its Metabolites Alter Polymerization and Gelation of Actin. Science 1979, 206: 1404-1406. PMID: 574316, DOI: 10.1126/science.574316.
- Stellaard F, Bolt M, Boyer J, Klein P. Phenobarbital treatment in primary biliary cirrhosis. Differences in bile acid composition between responders and nonresponders. Translational Research 1979, 94: 853-61. PMID: 501209.
- Tavoloni N, Reed J, Hruban Z, Boyer J. Effect of chlorpromazine on hepatic perfusion and bile secretory function in the isolated perfused rat liver. Translational Research 1979, 94: 726-41. PMID: 227976.
- Baker A, Wood R, Moossa A, Boyer J. Sodium Taurocholate Modifies the Bile Acid-Independent Fraction of Canalicular Bile Flow in the Rhesus Monkey. Journal Of Clinical Investigation 1979, 64: 312-320. PMID: 109471, PMCID: PMC372119, DOI: 10.1172/jci109453.
- Levin D, Baker A, Riddell R, Rochman H, Boyer J. Nonalcoholic liver disease Overlooked causes of liver injury in patients with heavy alcohol consumption. The American Journal Of Medicine 1979, 66: 429-434. PMID: 433949, DOI: 10.1016/0002-9343(79)91064-7.
- Baker A, Elson C, Jaspan J, Boyer J. Liver Failure With Steatonecrosis After Jejunoileal Bypass: Recovery With Parenteral Nutrition and Reanastomosis. JAMA Internal Medicine 1979, 139: 289-292. PMID: 106783, DOI: 10.1001/archinte.1979.03630400021012.
- Boyer J, Elias E, Layden T. The paracellular pathway and bile formation. The Yale Journal Of Biology And Medicine 1979, 52: 61-7. PMID: 452623, PMCID: PMC2595701.
- Hruban Z, Tavoloni N, Reed J, Boyer J. Ultrastructural changes during cholestasis induced by chlorpromazine in the isolated perfused rat liver. Cell Pathology 1978, 26: 289-305. DOI: 10.1007/bf02889557.
- Tavoloni N, Nemchausky B, Reed J, Boyer J. Metabolism affects the hepatic toxicity of chlorprohazine (CPZ) in the isolated perfused rat liver (IPRL). Gastroenterology 1978, 75: 990. DOI: 10.1016/0016-5085(78)90661-3.
- Blitzer B, Boyer J. Cytochemical localization of Na+, K+-ATPase in the rat hepatocyte. Journal Of Clinical Investigation 1978, 62: 1104-1108. PMID: 213446, PMCID: PMC371871, DOI: 10.1172/jci109216.
- Tavoloni N, Reed J, Boyer J. Hemodynamic effects on determinants of bile secretion in isolated rat liver. American Journal Of Physiology 1978, 234: e584. PMID: 665761, DOI: 10.1152/ajpendo.1978.234.6.e584.
- Haines N, Baker A, Glagov S, Ferguson D, Landau R, Boyer J. A prospective study of prognostic indicators of liver disease following jejunoileal bypass (JIB). Gastroenterology 1978, 74: 1170. DOI: 10.1016/0016-5085(78)93666-1.
- Schneider J, Schoeller D, Nemchausky B, Boyer J, Klein P. Validation of 13CO2 breath analysis as a measurement of demethylation of stable isotope labeled aminopyrine in man. Clinica Chimica Acta 1978, 84: 153-162. PMID: 639299, DOI: 10.1016/0009-8981(78)90489-8.
- Hruban Z, Tavoloni N, Reed J, Boyer J. Ultrastructural changes during cholestasis induced by chlorpromazine in the isolated perfused rat liver. Cell Pathology 1978, 26: 289-305. PMID: 416590, DOI: 10.1007/bf02889557.
- Bagheri S, Bolt M, Boyer J, Palmer R. Stimulation of thymidine incorporation in mouse liver and biliary tract epithelium by lithocholate and deoxycholate. Gastroenterology 1978, 74: 188-192. PMID: 620891, DOI: 10.1016/0016-5085(78)90793-x.
- Layden T, Boyer J. Taurolithocholate-Induced Cholestasis: Taurocholate, but not Dehydrocholate, Reverses Cholestasis and Bile Canalicular Membrane Injury. Gastroenterology 1977, 73: 120-128. PMID: 863183, DOI: 10.1016/s0016-5085(19)32283-8.
- Nemchausky B, Layden T, Boyer J. Effects of chronic choleretic infusions of bile acids on the membrane of the bile canaliculus. A biochemical and morphologic study. Laboratory Investigation 1977, 36: 259-67. PMID: 138767.
- WOOD R, BAKER A, HALL A, BOYER J, MOOSSA A. Evaluation of a New Monkey Model for the Repeated Study of Bile Secretory Physiology. Annals Of Surgery 1977, 185: 349-355. PMID: 402891, PMCID: PMC1396621, DOI: 10.1097/00000658-197703000-00017.
- Boyer J, Schwarz J, Smith N. Selective Hepatic Uptake and Biliary Excretion of 35S-Sulfobromophthalein in Marine Elasmobranchs. Gastroenterology 1976, 70: 254-256. PMID: 1248686, DOI: 10.1016/s0016-5085(76)80019-4.
- Layden T, Schwarz J, Boyer J. Scanning Electron Microscopy of the Rat Liver Studies of the effect of taurolithocholate and other models of cholestasis. Gastroenterology 1975, 69: 724-738. PMID: 1158090, DOI: 10.1016/s0016-5085(19)32475-8.
- Boyer J, Bloomer J, Maddrey W, Tilson D. Variation in hepatic bile composition following cholecystectomy in patients with previous gallstones. The Yale Journal Of Biology And Medicine 1974, 47: 211-7. PMID: 4456833, PMCID: PMC2595121.
- Hruban Z, Russell R, Boyer J, Glagov S, Bagheri S. Ultrastructural changes in livers of two patients with hypervitaminosis A. American Journal Of Pathology 1974, 76: 451-61. PMID: 4416771, PMCID: PMC1910880.
- Russell R, Boyer J, Bagheri S, Hruban Z. Hepatic Injury from Chronic Hypervitaminosis a Resulting in Portal Hypertension and Ascites. New England Journal Of Medicine 1974, 291: 435-440. PMID: 4843409, DOI: 10.1056/nejm197408292910903.
- Bloomer J, Boyer J, Klatskin G. Inhibition of Bilirubin Excretion in Man During Dehydrocholate Choleresis. Gastroenterology 1973, 65: 929-935. PMID: 4753351, DOI: 10.1016/s0016-5085(19)32986-5.
- Boyer J, Klatskin G. Canalicular Bile flow and Bile Secretory Pressure Evidence for a non-bile salt dependent fraction in the isolated perfused rat liver. Gastroenterology 1970, 59: 853-859. PMID: 5486271, DOI: 10.1016/s0016-5085(19)33645-5.
- Boyer J, Scheig R. Inhibition of Postheparin Lipolytic Activity in Uremia and its Relationship to Hypertriglyceridemia 1. Experimental Biology And Medicine 1970, 134: 603-605. PMID: 5431345, DOI: 10.3181/00379727-134-34842.
- Boyer J, Scheig R, Klatskin G. The effect of sodium taurocholate on the hepatic metabolism of sulfobromophthalein sodium (BSP). The role of bile flow. Journal Of Clinical Investigation 1970, 49: 206-215. PMID: 5411780, PMCID: PMC322462, DOI: 10.1172/jci106229.
- Boyer J, Scheig R. Hepatic metabolism of 1‐14C octanoic and 1‐14C margaric acids. Lipids 1969, 4: 615-617. PMID: 5367946, DOI: 10.1007/bf02531049.
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