- Yale Digestive DiseasesTemple Medical Center40 Temple Street, Ste Suite 1ANew Haven, CT 06510
- Yale Digestive DiseasesYale New Haven Hospital20 York StreetNew Haven, CT 06510
James Boyer, MD, FACEP
Biography
James L. Boyer, MD, specializes in liver diseases, a field he decided to pursue during a stint with the U.S. Health Service in Calcutta, India, during his medical residency. He views each case as unique and approaches each patient with flexibility. “It is important to emphasize that each patient's condition is different and not necessarily as described classically in a textbook or online, and that there is a great deal that we can do to help,” he says.
A professor of medicine (digestive diseases) at Yale School of Medicine, Dr. Boyer is also emeritus director of the Yale Liver Center, which he founded, and he has worked to improve care on a national level serving such organizations as the American Liver Foundation.
Dr. Boyer focuses his clinical practice on autoimmune and cholestatic liver diseases, which can lead to cirrhosis, and is optimistic about recent advances in the understanding of these ailments. “There are many new treatments in development that look promising,” he says. His most memorable patient was the first patient he recommended for a liver transplant. She was a young woman with cirrhosis who doctors predicted would die in several years. Under Dr. Boyer’s care, she lived another 46 years.
Titles
- Ensign Professor of Medicine (Digestive Diseases)
- Emeritus Director, Yale Liver Center
Education & Training
- FellowYale School of Medicine (1969)
- ResidentYale - New Haven Hospital (1967)
- ResidentNew York Hospital (1964)
- MDJohns Hopkins University (1962)
- ABHaverford College, Biology (1958)
Additional Information
- Emeritus Director, Yale Liver Center: (2020)
- International Recognition Award: European Association for the Study of Liver Disease (2019)
- Johns Hopkins Society of Scholars -2016: Johns Hopkins University (2016)
- Spinoza Profesesorship: University of Amsterdam, the Netherlands (2009)
- NIH MERIT Award: National Institutes of Health (2008)
- Distinguished Scientific Achievement Award: American Liver foundation (1999)
- Distinguished Achievement Award: American Association for the Study of the Liver (1998)
- Ismar-Boas Medal: German Society of Gastroenterology and Metabolism (1996)
- Ensign Professorship: Yale University (1996)
- Distinguished Achievement Award: American Gastroenterology Association (1989)
- AB of Internal Medicine, Internal Medicine (1969)
- Haverford College (2009 - Present): Board Member
- Mt Desert Island Biological Laboratory (1995 - 2013): Board Member
- American Liver Foundation (1976 - Present): voluntary health agency
- Yale University School of Medicine: Committee Member
- Zhao N, Zhang X, Ding J, Pan Q, Zheng MH, Liu WY, Luo G, Qu J, Li M, Li L, Cheng Y, Peng Y, Xie Q, Wei Q, Li Q, Zou L, Ouyang X, Cai SY, Boyer JL, Chai J. SEMA7AR148W mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface. JCI Insight 2022, 7 PMID: 35938531, DOI: 10.1172/jci.insight.154113.
- Gallucci GM, Alsuwayt B, Auclair AM, Boyer JL, Assis DN, Ghonem NS. Fenofibrate Downregulates NF-κB Signaling to Inhibit Pro-inflammatory Cytokine Secretion in Human THP-1 Macrophages and During Primary Biliary Cholangitis. Inflammation 2022 PMID: 35838934, DOI: 10.1007/s10753-022-01713-1.
- Alrabadi LS, Dutton A, Rabiee A, Roberts SJ, Deng Y, Cusack L, Silveira MG, Ciarleglio M, Bucala R, Sinha R, Boyer JL, Assis DN. Mindfulness-based stress reduction may decrease stress, disease activity, and inflammatory cytokine levels in patients with autoimmune hepatitis. JHEP Reports (Online) 2022, 4: 100450. PMID: 35434588, PMCID: PMC9011026, DOI: 10.1016/j.jhepr.2022.100450.
- Lindor KD, Bowlus CL, Boyer J, Levy C, Mayo M. Primary biliary cholangitis: 2021 practice guidance update from the American Association for the Study of Liver Diseases. Hepatology (Baltimore, Md.) 2022, 75: 1012-1013. PMID: 34431119, DOI: 10.1002/hep.32117.
- Efe C, Lammert C, Taşçılar K, Dhanasekaran R, Ebik B, Higuera-de la Tijera F, Calışkan AR, Peralta M, Gerussi A, Massoumi H, Catana AM, Purnak T, Rigamonti C, Aldana AJG, Khakoo N, Nazal L, Frager S, Demir N, Irak K, Melekoğlu-Ellik Z, Kacmaz H, Balaban Y, Atay K, Eren F, Alvares-da-Silva MR, Cristoferi L, Urzua Á, Eşkazan T, Magro B, Snijders R, Barutçu S, Lytvyak E, Zazueta GM, Demirezer-Bolat A, Aydın M, Heurgue-Berlot A, De Martin E, Ekin N, Yıldırım S, Yavuz A, Bıyık M, Narro GC, Kıyıcı M, Akyıldız M, Kahramanoğlu-Aksoy E, Vincent M, Carr RM, Günşar F, Reyes EC, Harputluoğlu M, Aloman C, Gatselis NK, Üstündağ Y, Brahm J, Vargas NCE, Güzelbulut F, Garcia SR, Aguirre J, Anders M, Ratusnu N, Hatemi I, Mendizabal M, Floreani A, Fagiuoli S, Silva M, Idilman R, Satapathy SK, Silveira M, Drenth JPH, Dalekos GN, Assis DN, Björnsson E, Boyer JL, Yoshida EM, Invernizzi P, Levy C, Montano-Loza AJ, Schiano TD, Ridruejo E, Wahlin S. Effects of immunosuppressive drugs on COVID-19 severity in patients with autoimmune hepatitis. Liver International : Official Journal Of The International Association For The Study Of The Liver 2022, 42: 607-614. PMID: 34846800, DOI: 10.1111/liv.15121.
- Javitt NB, Boyer JL. Letter to the Editor: On the mechanisms of biliary flux. Hepatology (Baltimore, Md.) 2022, 75: 492-493. PMID: 34543482, DOI: 10.1002/hep.32167.
- Boyer JL, Wolkoff AW. Paul David Berk, editor extraordinaire and bilirubinologist. Hepatology (Baltimore, Md.) 2022, 75: 236-237. PMID: 34403150, DOI: 10.1002/hep.32104.
- Gallucci GM, Trottier J, Hemme C, Assis DN, Boyer JL, Barbier O, Ghonem NS. Adjunct Fenofibrate Up-regulates Bile Acid Glucuronidation and Improves Treatment Response For Patients With Cholestasis. Hepatology Communications 2021, 5: 2035-2051. PMID: 34558841, PMCID: PMC8631103, DOI: 10.1002/hep4.1787.
- Pan Q, Luo G, Qu J, Chen S, Zhang X, Zhao N, Ding J, Yang H, Li M, Li L, Cheng Y, Li X, Xie Q, Li Q, Zhou X, Zou H, Fan S, Zou L, Liu W, Deng G, Cai SY, Boyer JL, Chai J. A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis. EMBO Molecular Medicine 2021, 13: e14563. PMID: 34585848, PMCID: PMC8573601, DOI: 10.15252/emmm.202114563.
- Shah V, Iwakiri Y, Boyer JL. Obituary for Roberto J. Groszmann-The Father of Portal Hypertension. Hepatology (Baltimore, Md.) 2021, 74: 1724-1726. PMID: 34105802, DOI: 10.1002/hep.31996.
- Stieger B, Boyer JL. In Memoriam: Peter J. Meier (1947-2021). Journal Of Hepatology 2021 PMID: 34332756, DOI: 10.1016/j.jhep.2021.06.039.
- Boyer JL, Soroka CJ. Bile formation and secretion: An update. Journal Of Hepatology 2021, 75: 190-201. PMID: 33617926, DOI: 10.1016/j.jhep.2021.02.011.
- Efe C, Dhanasekaran R, Lammert C, Ebik B, Higuera-de la Tijera F, Aloman C, Rıza Calışkan A, Peralta M, Gerussi A, Massoumi H, Catana AM, Torgutalp M, Purnak T, Rigamonti C, Gomez Aldana AJ, Khakoo N, Kacmaz H, Nazal L, Frager S, Demir N, Irak K, Ellik ZM, Balaban Y, Atay K, Eren F, Cristoferi L, Batıbay E, Urzua Á, Snijders R, Kıyıcı M, Akyıldız M, Ekin N, Carr RM, Harputluoğlu M, Hatemi I, Mendizabal M, Silva M, Idilman R, Silveira M, Drenth JPH, Assis DN, Björnsson E, Boyer JL, Invernizzi P, Levy C, Schiano TD, Ridruejo E, Wahlin S. Outcome of COVID-19 in Patients With Autoimmune Hepatitis: An International Multicenter Study. Hepatology (Baltimore, Md.) 2021, 73: 2099-2109. PMID: 33713486, PMCID: PMC8250536, DOI: 10.1002/hep.31797.
- Li B, Cai SY, Boyer JL. The role of the retinoid receptor, RAR/RXR heterodimer, in liver physiology. Biochimica Et Biophysica Acta. Molecular Basis Of Disease 2021, 1867: 166085. PMID: 33497820, DOI: 10.1016/j.bbadis.2021.166085.
- Soroka CJ, Roberts SJ, Boyer JL, Assis DN. Role of Biliary Organoids in Cholestasis Research and Regenerative Medicine. Seminars In Liver Disease 2021, 41: 206-212. PMID: 33957696, DOI: 10.1055/s-0041-1728663.
- Cai SY, Boyer JL. The role of bile acids in cholestatic liver injury. Annals Of Translational Medicine 2021, 9: 737. PMID: 33987435, PMCID: PMC8106037, DOI: 10.21037/atm-20-5110.
- Cai SY, Yu D, Soroka CJ, Wang J, Boyer JL. Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis. Journal Of Hepatology 2021, 74: 550-559. PMID: 33039404, PMCID: PMC7897288, DOI: 10.1016/j.jhep.2020.09.035.
- Ghonem NS, Auclair AM, Hemme CL, Gallucci GM, de la Rosa Rodriguez R, Boyer JL, Assis DN. Fenofibrate Improves Liver Function and Reduces the Toxicity of the Bile Acid Pool in Patients With Primary Biliary Cholangitis and Primary Sclerosing Cholangitis Who Are Partial Responders to Ursodiol. Clinical Pharmacology And Therapeutics 2020, 108: 1213-1223. PMID: 32480421, PMCID: PMC7886378, DOI: 10.1002/cpt.1930.
- Gao E, Cheema H, Waheed N, Mushtaq I, Erden N, Nelson-Williams C, Jain D, Soroka CJ, Boyer JL, Khalil Y, Clayton PT, Mistry PK, Lifton RP, Vilarinho S. Organic Solute Transporter Alpha Deficiency: A Disorder With Cholestasis, Liver Fibrosis, and Congenital Diarrhea. Hepatology (Baltimore, Md.) 2020, 71: 1879-1882. PMID: 31863603, PMCID: PMC8577800, DOI: 10.1002/hep.31087.
- Cai SY, Ge M, Mennone A, Hoque R, Ouyang X, Boyer JL. Inflammasome Is Activated in the Liver of Cholestatic Patients and Aggravates Hepatic Injury in Bile Duct-Ligated Mouse. Cellular And Molecular Gastroenterology And Hepatology 2020, 9: 679-688. PMID: 31887435, PMCID: PMC7160576, DOI: 10.1016/j.jcmgh.2019.12.008.
- Soroka CJ, Assis DN, Alrabadi LS, Roberts S, Cusack L, Jaffe AB, Boyer JL. Bile-Derived Organoids From Patients With Primary Sclerosing Cholangitis Recapitulate Their Inflammatory Immune Profile. Hepatology (Baltimore, Md.) 2019, 70: 871-882. PMID: 30561836, DOI: 10.1002/hep.30470.
- Cai SY, Boyer JL. Bile Infarcts: New Insights Into the Pathogenesis of Obstructive Cholestasis. Hepatology (Baltimore, Md.) 2019, 69: 473-475. PMID: 30251326, DOI: 10.1002/hep.30291.
- Lindor KD, Bowlus CL, Boyer J, Levy C, Mayo M. Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases. Hepatology (Baltimore, Md.) 2019, 69: 394-419. PMID: 30070375, DOI: 10.1002/hep.30145.
- Soroka CJ, Assis DN, Boyer JL. Patient-Derived Organoids from Human Bile: An In Vitro Method to Study Cholangiopathies. Methods In Molecular Biology (Clifton, N.J.) 2019, 1981: 363-372. PMID: 31016667, DOI: 10.1007/978-1-4939-9420-5_24.
- Pan Q, Zhang X, Zhang L, Cheng Y, Zhao N, Li F, Zhou X, Chen S, Li J, Xu S, Huang D, Chen Y, Li L, Wang H, Chen W, Cai SY, Boyer JL, Chai J. Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis. Gastroenterology 2018, 155: 1578-1592.e16. PMID: 30063921, PMCID: PMC6221191, DOI: 10.1053/j.gastro.2018.07.031.
- Yu D, Cai SY, Mennone A, Vig P, Boyer JL. Cenicriviroc, a cytokine receptor antagonist, potentiates all-trans retinoic acid in reducing liver injury in cholestatic rodents. Liver International : Official Journal Of The International Association For The Study Of The Liver 2018, 38: 1128-1138. PMID: 29356312, PMCID: PMC6032984, DOI: 10.1111/liv.13698.
- Goldberg DS, Levy C, Yimam K, Gordon SC, Forman L, Verna E, Yu L, Rahimi R, Schwarz K, Eksteen B, Pratt D, Boyer JL, Assis D, Bowlus C. Primary Sclerosing Cholangitis Is Not Rare Among Blacks in a Multicenter North American Consortium. Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association 2018, 16: 591-593. PMID: 29102704, PMCID: PMC5860952, DOI: 10.1016/j.cgh.2017.10.028.
- Boyer JL. OSTα-OSTβ Guards the Ileal Enterocyte From the Accumulation of Toxic Levels of Bile Acids. Cellular And Molecular Gastroenterology And Hepatology 2018, 5: 649-650. PMID: 29713669, PMCID: PMC5924743, DOI: 10.1016/j.jcmgh.2018.01.015.
- Boyer JL. Maintaining a Vibrant and Productive Laboratory as a Senior Investigator. Cellular And Molecular Gastroenterology And Hepatology 2017, 4: 299-300. PMID: 28840184, PMCID: PMC5560913, DOI: 10.1016/j.jcmgh.2017.04.008.
- Li M, Cai SY, Boyer JL. Mechanisms of bile acid mediated inflammation in the liver. Molecular Aspects Of Medicine 2017, 56: 45-53. PMID: 28606651, PMCID: PMC5662014, DOI: 10.1016/j.mam.2017.06.001.
- Cai SY, Ouyang X, Chen Y, Soroka CJ, Wang J, Mennone A, Wang Y, Mehal WZ, Jain D, Boyer JL. Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response. JCI Insight 2017, 2: e90780. PMID: 28289714, PMCID: PMC5333973, DOI: 10.1172/jci.insight.90780.
- Assis DN, Abdelghany O, Cai SY, Gossard AA, Eaton JE, Keach JC, Deng Y, Setchell KD, Ciarleglio M, Lindor KD, Boyer JL. Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis: A Human Pilot Study. Journal Of Clinical Gastroenterology 2017, 51: e11-e16. PMID: 27428727, PMCID: PMC5218875, DOI: 10.1097/MCG.0000000000000591.
- Li M, Soroka CJ, Harry K, Boyer JL. CFTR-associated ligand is a negative regulator of Mrp2 expression. American Journal Of Physiology. Cell Physiology 2017, 312: C40-C46. PMID: 27834195, PMCID: PMC5283898, DOI: 10.1152/ajpcell.00100.2016.
- Cai SY, Boyer JL. Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury. Inflammation And Cell Signaling 2017, 4 PMID: 28804737, PMCID: PMC5553904.
- Kulkarni SR, Soroka CJ, Hagey LR, Boyer JL. Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid-fed mouse model of cholestasis. Hepatology (Baltimore, Md.) 2016, 64: 2151-2164. PMID: 27639250, PMCID: PMC5115990, DOI: 10.1002/hep.28826.
- Xu S, Soroka CJ, Sun AQ, Backos DS, Mennone A, Suchy FJ, Boyer JL. A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization. PloS One 2016, 11: e0158269. PMID: 27351185, PMCID: PMC4924846, DOI: 10.1371/journal.pone.0158269.
- Chai J, Cai SY, Liu X, Lian W, Chen S, Zhang L, Feng X, Cheng Y, He X, He Y, Chen L, Wang R, Wang H, Boyer JL, Chen W. Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis. Journal Of Hepatology 2015, 63: 1440-8. PMID: 26212029, PMCID: PMC4686151, DOI: 10.1016/j.jhep.2015.07.016.
- Li M, Mennone A, Soroka CJ, Hagey LR, Ouyang X, Weinman EJ, Boyer JL. Na(+) /H(+) exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury. Hepatology (Baltimore, Md.) 2015, 62: 1227-36. PMID: 26108984, PMCID: PMC4589453, DOI: 10.1002/hep.27956.
- Ghonem NS, Assis DN, Boyer JL. Fibrates and cholestasis. Hepatology (Baltimore, Md.) 2015, 62: 635-43. PMID: 25678132, PMCID: PMC4515188, DOI: 10.1002/hep.27744.
- Boyer JL. The origins of hepatobiliary and gastrointestinal physiology. Hepatology (Baltimore, Md.) 2015, 61: 1452-4. PMID: 25677183, PMCID: PMC4447183, DOI: 10.1002/hep.27737.
- Soroka CJ, Boyer JL. Biosynthesis and trafficking of the bile salt export pump, BSEP: therapeutic implications of BSEP mutations. Molecular Aspects Of Medicine 2014, 37: 3-14. PMID: 23685087, PMCID: PMC3784619, DOI: 10.1016/j.mam.2013.05.001.
- Assis DN, Leng L, Du X, Zhang CK, Grieb G, Merk M, Garcia AB, McCrann C, Chapiro J, Meinhardt A, Mizue Y, Nikolic-Paterson DJ, Bernhagen J, Kaplan MM, Zhao H, Boyer JL, Bucala R. The role of macrophage migration inhibitory factor in autoimmune liver disease. Hepatology (Baltimore, Md.) 2014, 59: 580-91. PMID: 23913513, PMCID: PMC3877200, DOI: 10.1002/hep.26664.
- Boyer JL. Bile formation and secretion. Comprehensive Physiology 2013, 3: 1035-78. PMID: 23897680, PMCID: PMC4091928, DOI: 10.1002/cphy.c120027.
- Cai SY, Lionarons DA, Hagey L, Soroka CJ, Mennone A, Boyer JL. Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion. Hepatology (Baltimore, Md.) 2013, 57: 2418-26. PMID: 23175353, PMCID: PMC3604052, DOI: 10.1002/hep.26161.
- Lam P, Xu S, Soroka CJ, Boyer JL. A C-terminal tyrosine-based motif in the bile salt export pump directs clathrin-dependent endocytosis. Hepatology (Baltimore, Md.) 2012, 55: 1901-11. PMID: 22161577, PMCID: PMC3319652, DOI: 10.1002/hep.25523.
- Soroka CJ, Velazquez H, Mennone A, Ballatori N, Boyer JL. Ostα depletion protects liver from oral bile acid load. American Journal Of Physiology. Gastrointestinal And Liver Physiology 2011, 301: G574-9. PMID: 21719738, PMCID: PMC3174539, DOI: 10.1152/ajpgi.00141.2011.
- Padda MS, Sanchez M, Akhtar AJ, Boyer JL. Drug-induced cholestasis. Hepatology (Baltimore, Md.) 2011, 53: 1377-87. PMID: 21480339, PMCID: PMC3089004, DOI: 10.1002/hep.24229.
- He H, Mennone A, Boyer JL, Cai SY. Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells. Hepatology (Baltimore, Md.) 2011, 53: 548-57. PMID: 21274875, PMCID: PMC3069505, DOI: 10.1002/hep.24047.
- Boyer JL. It's all about bile. Hepatology (Baltimore, Md.) 2009, 49: 711-23. PMID: 19242972, DOI: 10.1002/hep.22719.
- Cai SY, Gautam S, Nguyen T, Soroka CJ, Rahner C, Boyer JL. ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained. Gastroenterology 2009, 136: 1060-9. PMID: 19027009, PMCID: PMC3439851, DOI: 10.1053/j.gastro.2008.10.025.
- Cai SY, Wang L, Ballatori N, Boyer JL. Bile salt export pump is highly conserved during vertebrate evolution and its expression is inhibited by PFIC type II mutations. American Journal Of Physiology. Gastrointestinal And Liver Physiology 2001, 281: G316-22. PMID: 11447010, DOI: 10.1152/ajpgi.2001.281.2.G316.
- Yale Digestive DiseasesTemple Medical Center40 Temple Street, Ste Suite 1ANew Haven, CT 06510
- Yale Digestive DiseasesYale New Haven Hospital20 York StreetNew Haven, CT 06510
Biography
James L. Boyer, MD, specializes in liver diseases, a field he decided to pursue during a stint with the U.S. Health Service in Calcutta, India, during his medical residency. He views each case as unique and approaches each patient with flexibility. “It is important to emphasize that each patient's condition is different and not necessarily as described classically in a textbook or online, and that there is a great deal that we can do to help,” he says.
A professor of medicine (digestive diseases) at Yale School of Medicine, Dr. Boyer is also emeritus director of the Yale Liver Center, which he founded, and he has worked to improve care on a national level serving such organizations as the American Liver Foundation.
Dr. Boyer focuses his clinical practice on autoimmune and cholestatic liver diseases, which can lead to cirrhosis, and is optimistic about recent advances in the understanding of these ailments. “There are many new treatments in development that look promising,” he says. His most memorable patient was the first patient he recommended for a liver transplant. She was a young woman with cirrhosis who doctors predicted would die in several years. Under Dr. Boyer’s care, she lived another 46 years.
Titles
- Ensign Professor of Medicine (Digestive Diseases)
- Emeritus Director, Yale Liver Center
Education & Training
- FellowYale School of Medicine (1969)
- ResidentYale - New Haven Hospital (1967)
- ResidentNew York Hospital (1964)
- MDJohns Hopkins University (1962)
- ABHaverford College, Biology (1958)
Additional Information
- Emeritus Director, Yale Liver Center: (2020)
- International Recognition Award: European Association for the Study of Liver Disease (2019)
- Johns Hopkins Society of Scholars -2016: Johns Hopkins University (2016)
- Spinoza Profesesorship: University of Amsterdam, the Netherlands (2009)
- NIH MERIT Award: National Institutes of Health (2008)
- Distinguished Scientific Achievement Award: American Liver foundation (1999)
- Distinguished Achievement Award: American Association for the Study of the Liver (1998)
- Ismar-Boas Medal: German Society of Gastroenterology and Metabolism (1996)
- Ensign Professorship: Yale University (1996)
- Distinguished Achievement Award: American Gastroenterology Association (1989)
- AB of Internal Medicine, Internal Medicine (1969)
- Haverford College (2009 - Present): Board Member
- Mt Desert Island Biological Laboratory (1995 - 2013): Board Member
- American Liver Foundation (1976 - Present): voluntary health agency
- Yale University School of Medicine: Committee Member
- Zhao N, Zhang X, Ding J, Pan Q, Zheng MH, Liu WY, Luo G, Qu J, Li M, Li L, Cheng Y, Peng Y, Xie Q, Wei Q, Li Q, Zou L, Ouyang X, Cai SY, Boyer JL, Chai J. SEMA7AR148W mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface. JCI Insight 2022, 7 PMID: 35938531, DOI: 10.1172/jci.insight.154113.
- Gallucci GM, Alsuwayt B, Auclair AM, Boyer JL, Assis DN, Ghonem NS. Fenofibrate Downregulates NF-κB Signaling to Inhibit Pro-inflammatory Cytokine Secretion in Human THP-1 Macrophages and During Primary Biliary Cholangitis. Inflammation 2022 PMID: 35838934, DOI: 10.1007/s10753-022-01713-1.
- Alrabadi LS, Dutton A, Rabiee A, Roberts SJ, Deng Y, Cusack L, Silveira MG, Ciarleglio M, Bucala R, Sinha R, Boyer JL, Assis DN. Mindfulness-based stress reduction may decrease stress, disease activity, and inflammatory cytokine levels in patients with autoimmune hepatitis. JHEP Reports (Online) 2022, 4: 100450. PMID: 35434588, PMCID: PMC9011026, DOI: 10.1016/j.jhepr.2022.100450.
- Lindor KD, Bowlus CL, Boyer J, Levy C, Mayo M. Primary biliary cholangitis: 2021 practice guidance update from the American Association for the Study of Liver Diseases. Hepatology (Baltimore, Md.) 2022, 75: 1012-1013. PMID: 34431119, DOI: 10.1002/hep.32117.
- Efe C, Lammert C, Taşçılar K, Dhanasekaran R, Ebik B, Higuera-de la Tijera F, Calışkan AR, Peralta M, Gerussi A, Massoumi H, Catana AM, Purnak T, Rigamonti C, Aldana AJG, Khakoo N, Nazal L, Frager S, Demir N, Irak K, Melekoğlu-Ellik Z, Kacmaz H, Balaban Y, Atay K, Eren F, Alvares-da-Silva MR, Cristoferi L, Urzua Á, Eşkazan T, Magro B, Snijders R, Barutçu S, Lytvyak E, Zazueta GM, Demirezer-Bolat A, Aydın M, Heurgue-Berlot A, De Martin E, Ekin N, Yıldırım S, Yavuz A, Bıyık M, Narro GC, Kıyıcı M, Akyıldız M, Kahramanoğlu-Aksoy E, Vincent M, Carr RM, Günşar F, Reyes EC, Harputluoğlu M, Aloman C, Gatselis NK, Üstündağ Y, Brahm J, Vargas NCE, Güzelbulut F, Garcia SR, Aguirre J, Anders M, Ratusnu N, Hatemi I, Mendizabal M, Floreani A, Fagiuoli S, Silva M, Idilman R, Satapathy SK, Silveira M, Drenth JPH, Dalekos GN, Assis DN, Björnsson E, Boyer JL, Yoshida EM, Invernizzi P, Levy C, Montano-Loza AJ, Schiano TD, Ridruejo E, Wahlin S. Effects of immunosuppressive drugs on COVID-19 severity in patients with autoimmune hepatitis. Liver International : Official Journal Of The International Association For The Study Of The Liver 2022, 42: 607-614. PMID: 34846800, DOI: 10.1111/liv.15121.
- Javitt NB, Boyer JL. Letter to the Editor: On the mechanisms of biliary flux. Hepatology (Baltimore, Md.) 2022, 75: 492-493. PMID: 34543482, DOI: 10.1002/hep.32167.
- Boyer JL, Wolkoff AW. Paul David Berk, editor extraordinaire and bilirubinologist. Hepatology (Baltimore, Md.) 2022, 75: 236-237. PMID: 34403150, DOI: 10.1002/hep.32104.
- Gallucci GM, Trottier J, Hemme C, Assis DN, Boyer JL, Barbier O, Ghonem NS. Adjunct Fenofibrate Up-regulates Bile Acid Glucuronidation and Improves Treatment Response For Patients With Cholestasis. Hepatology Communications 2021, 5: 2035-2051. PMID: 34558841, PMCID: PMC8631103, DOI: 10.1002/hep4.1787.
- Pan Q, Luo G, Qu J, Chen S, Zhang X, Zhao N, Ding J, Yang H, Li M, Li L, Cheng Y, Li X, Xie Q, Li Q, Zhou X, Zou H, Fan S, Zou L, Liu W, Deng G, Cai SY, Boyer JL, Chai J. A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis. EMBO Molecular Medicine 2021, 13: e14563. PMID: 34585848, PMCID: PMC8573601, DOI: 10.15252/emmm.202114563.
- Shah V, Iwakiri Y, Boyer JL. Obituary for Roberto J. Groszmann-The Father of Portal Hypertension. Hepatology (Baltimore, Md.) 2021, 74: 1724-1726. PMID: 34105802, DOI: 10.1002/hep.31996.
- Stieger B, Boyer JL. In Memoriam: Peter J. Meier (1947-2021). Journal Of Hepatology 2021 PMID: 34332756, DOI: 10.1016/j.jhep.2021.06.039.
- Boyer JL, Soroka CJ. Bile formation and secretion: An update. Journal Of Hepatology 2021, 75: 190-201. PMID: 33617926, DOI: 10.1016/j.jhep.2021.02.011.
- Efe C, Dhanasekaran R, Lammert C, Ebik B, Higuera-de la Tijera F, Aloman C, Rıza Calışkan A, Peralta M, Gerussi A, Massoumi H, Catana AM, Torgutalp M, Purnak T, Rigamonti C, Gomez Aldana AJ, Khakoo N, Kacmaz H, Nazal L, Frager S, Demir N, Irak K, Ellik ZM, Balaban Y, Atay K, Eren F, Cristoferi L, Batıbay E, Urzua Á, Snijders R, Kıyıcı M, Akyıldız M, Ekin N, Carr RM, Harputluoğlu M, Hatemi I, Mendizabal M, Silva M, Idilman R, Silveira M, Drenth JPH, Assis DN, Björnsson E, Boyer JL, Invernizzi P, Levy C, Schiano TD, Ridruejo E, Wahlin S. Outcome of COVID-19 in Patients With Autoimmune Hepatitis: An International Multicenter Study. Hepatology (Baltimore, Md.) 2021, 73: 2099-2109. PMID: 33713486, PMCID: PMC8250536, DOI: 10.1002/hep.31797.
- Li B, Cai SY, Boyer JL. The role of the retinoid receptor, RAR/RXR heterodimer, in liver physiology. Biochimica Et Biophysica Acta. Molecular Basis Of Disease 2021, 1867: 166085. PMID: 33497820, DOI: 10.1016/j.bbadis.2021.166085.
- Soroka CJ, Roberts SJ, Boyer JL, Assis DN. Role of Biliary Organoids in Cholestasis Research and Regenerative Medicine. Seminars In Liver Disease 2021, 41: 206-212. PMID: 33957696, DOI: 10.1055/s-0041-1728663.
- Cai SY, Boyer JL. The role of bile acids in cholestatic liver injury. Annals Of Translational Medicine 2021, 9: 737. PMID: 33987435, PMCID: PMC8106037, DOI: 10.21037/atm-20-5110.
- Cai SY, Yu D, Soroka CJ, Wang J, Boyer JL. Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis. Journal Of Hepatology 2021, 74: 550-559. PMID: 33039404, PMCID: PMC7897288, DOI: 10.1016/j.jhep.2020.09.035.
- Ghonem NS, Auclair AM, Hemme CL, Gallucci GM, de la Rosa Rodriguez R, Boyer JL, Assis DN. Fenofibrate Improves Liver Function and Reduces the Toxicity of the Bile Acid Pool in Patients With Primary Biliary Cholangitis and Primary Sclerosing Cholangitis Who Are Partial Responders to Ursodiol. Clinical Pharmacology And Therapeutics 2020, 108: 1213-1223. PMID: 32480421, PMCID: PMC7886378, DOI: 10.1002/cpt.1930.
- Gao E, Cheema H, Waheed N, Mushtaq I, Erden N, Nelson-Williams C, Jain D, Soroka CJ, Boyer JL, Khalil Y, Clayton PT, Mistry PK, Lifton RP, Vilarinho S. Organic Solute Transporter Alpha Deficiency: A Disorder With Cholestasis, Liver Fibrosis, and Congenital Diarrhea. Hepatology (Baltimore, Md.) 2020, 71: 1879-1882. PMID: 31863603, PMCID: PMC8577800, DOI: 10.1002/hep.31087.
- Cai SY, Ge M, Mennone A, Hoque R, Ouyang X, Boyer JL. Inflammasome Is Activated in the Liver of Cholestatic Patients and Aggravates Hepatic Injury in Bile Duct-Ligated Mouse. Cellular And Molecular Gastroenterology And Hepatology 2020, 9: 679-688. PMID: 31887435, PMCID: PMC7160576, DOI: 10.1016/j.jcmgh.2019.12.008.
- Soroka CJ, Assis DN, Alrabadi LS, Roberts S, Cusack L, Jaffe AB, Boyer JL. Bile-Derived Organoids From Patients With Primary Sclerosing Cholangitis Recapitulate Their Inflammatory Immune Profile. Hepatology (Baltimore, Md.) 2019, 70: 871-882. PMID: 30561836, DOI: 10.1002/hep.30470.
- Cai SY, Boyer JL. Bile Infarcts: New Insights Into the Pathogenesis of Obstructive Cholestasis. Hepatology (Baltimore, Md.) 2019, 69: 473-475. PMID: 30251326, DOI: 10.1002/hep.30291.
- Lindor KD, Bowlus CL, Boyer J, Levy C, Mayo M. Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases. Hepatology (Baltimore, Md.) 2019, 69: 394-419. PMID: 30070375, DOI: 10.1002/hep.30145.
- Soroka CJ, Assis DN, Boyer JL. Patient-Derived Organoids from Human Bile: An In Vitro Method to Study Cholangiopathies. Methods In Molecular Biology (Clifton, N.J.) 2019, 1981: 363-372. PMID: 31016667, DOI: 10.1007/978-1-4939-9420-5_24.
- Pan Q, Zhang X, Zhang L, Cheng Y, Zhao N, Li F, Zhou X, Chen S, Li J, Xu S, Huang D, Chen Y, Li L, Wang H, Chen W, Cai SY, Boyer JL, Chai J. Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis. Gastroenterology 2018, 155: 1578-1592.e16. PMID: 30063921, PMCID: PMC6221191, DOI: 10.1053/j.gastro.2018.07.031.
- Yu D, Cai SY, Mennone A, Vig P, Boyer JL. Cenicriviroc, a cytokine receptor antagonist, potentiates all-trans retinoic acid in reducing liver injury in cholestatic rodents. Liver International : Official Journal Of The International Association For The Study Of The Liver 2018, 38: 1128-1138. PMID: 29356312, PMCID: PMC6032984, DOI: 10.1111/liv.13698.
- Goldberg DS, Levy C, Yimam K, Gordon SC, Forman L, Verna E, Yu L, Rahimi R, Schwarz K, Eksteen B, Pratt D, Boyer JL, Assis D, Bowlus C. Primary Sclerosing Cholangitis Is Not Rare Among Blacks in a Multicenter North American Consortium. Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association 2018, 16: 591-593. PMID: 29102704, PMCID: PMC5860952, DOI: 10.1016/j.cgh.2017.10.028.
- Boyer JL. OSTα-OSTβ Guards the Ileal Enterocyte From the Accumulation of Toxic Levels of Bile Acids. Cellular And Molecular Gastroenterology And Hepatology 2018, 5: 649-650. PMID: 29713669, PMCID: PMC5924743, DOI: 10.1016/j.jcmgh.2018.01.015.
- Boyer JL. Maintaining a Vibrant and Productive Laboratory as a Senior Investigator. Cellular And Molecular Gastroenterology And Hepatology 2017, 4: 299-300. PMID: 28840184, PMCID: PMC5560913, DOI: 10.1016/j.jcmgh.2017.04.008.
- Li M, Cai SY, Boyer JL. Mechanisms of bile acid mediated inflammation in the liver. Molecular Aspects Of Medicine 2017, 56: 45-53. PMID: 28606651, PMCID: PMC5662014, DOI: 10.1016/j.mam.2017.06.001.
- Cai SY, Ouyang X, Chen Y, Soroka CJ, Wang J, Mennone A, Wang Y, Mehal WZ, Jain D, Boyer JL. Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response. JCI Insight 2017, 2: e90780. PMID: 28289714, PMCID: PMC5333973, DOI: 10.1172/jci.insight.90780.
- Assis DN, Abdelghany O, Cai SY, Gossard AA, Eaton JE, Keach JC, Deng Y, Setchell KD, Ciarleglio M, Lindor KD, Boyer JL. Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis: A Human Pilot Study. Journal Of Clinical Gastroenterology 2017, 51: e11-e16. PMID: 27428727, PMCID: PMC5218875, DOI: 10.1097/MCG.0000000000000591.
- Li M, Soroka CJ, Harry K, Boyer JL. CFTR-associated ligand is a negative regulator of Mrp2 expression. American Journal Of Physiology. Cell Physiology 2017, 312: C40-C46. PMID: 27834195, PMCID: PMC5283898, DOI: 10.1152/ajpcell.00100.2016.
- Cai SY, Boyer JL. Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury. Inflammation And Cell Signaling 2017, 4 PMID: 28804737, PMCID: PMC5553904.
- Kulkarni SR, Soroka CJ, Hagey LR, Boyer JL. Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid-fed mouse model of cholestasis. Hepatology (Baltimore, Md.) 2016, 64: 2151-2164. PMID: 27639250, PMCID: PMC5115990, DOI: 10.1002/hep.28826.
- Xu S, Soroka CJ, Sun AQ, Backos DS, Mennone A, Suchy FJ, Boyer JL. A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization. PloS One 2016, 11: e0158269. PMID: 27351185, PMCID: PMC4924846, DOI: 10.1371/journal.pone.0158269.
- Chai J, Cai SY, Liu X, Lian W, Chen S, Zhang L, Feng X, Cheng Y, He X, He Y, Chen L, Wang R, Wang H, Boyer JL, Chen W. Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis. Journal Of Hepatology 2015, 63: 1440-8. PMID: 26212029, PMCID: PMC4686151, DOI: 10.1016/j.jhep.2015.07.016.
- Li M, Mennone A, Soroka CJ, Hagey LR, Ouyang X, Weinman EJ, Boyer JL. Na(+) /H(+) exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury. Hepatology (Baltimore, Md.) 2015, 62: 1227-36. PMID: 26108984, PMCID: PMC4589453, DOI: 10.1002/hep.27956.
- Ghonem NS, Assis DN, Boyer JL. Fibrates and cholestasis. Hepatology (Baltimore, Md.) 2015, 62: 635-43. PMID: 25678132, PMCID: PMC4515188, DOI: 10.1002/hep.27744.
- Boyer JL. The origins of hepatobiliary and gastrointestinal physiology. Hepatology (Baltimore, Md.) 2015, 61: 1452-4. PMID: 25677183, PMCID: PMC4447183, DOI: 10.1002/hep.27737.
- Soroka CJ, Boyer JL. Biosynthesis and trafficking of the bile salt export pump, BSEP: therapeutic implications of BSEP mutations. Molecular Aspects Of Medicine 2014, 37: 3-14. PMID: 23685087, PMCID: PMC3784619, DOI: 10.1016/j.mam.2013.05.001.
- Assis DN, Leng L, Du X, Zhang CK, Grieb G, Merk M, Garcia AB, McCrann C, Chapiro J, Meinhardt A, Mizue Y, Nikolic-Paterson DJ, Bernhagen J, Kaplan MM, Zhao H, Boyer JL, Bucala R. The role of macrophage migration inhibitory factor in autoimmune liver disease. Hepatology (Baltimore, Md.) 2014, 59: 580-91. PMID: 23913513, PMCID: PMC3877200, DOI: 10.1002/hep.26664.
- Boyer JL. Bile formation and secretion. Comprehensive Physiology 2013, 3: 1035-78. PMID: 23897680, PMCID: PMC4091928, DOI: 10.1002/cphy.c120027.
- Cai SY, Lionarons DA, Hagey L, Soroka CJ, Mennone A, Boyer JL. Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion. Hepatology (Baltimore, Md.) 2013, 57: 2418-26. PMID: 23175353, PMCID: PMC3604052, DOI: 10.1002/hep.26161.
- Lam P, Xu S, Soroka CJ, Boyer JL. A C-terminal tyrosine-based motif in the bile salt export pump directs clathrin-dependent endocytosis. Hepatology (Baltimore, Md.) 2012, 55: 1901-11. PMID: 22161577, PMCID: PMC3319652, DOI: 10.1002/hep.25523.
- Soroka CJ, Velazquez H, Mennone A, Ballatori N, Boyer JL. Ostα depletion protects liver from oral bile acid load. American Journal Of Physiology. Gastrointestinal And Liver Physiology 2011, 301: G574-9. PMID: 21719738, PMCID: PMC3174539, DOI: 10.1152/ajpgi.00141.2011.
- Padda MS, Sanchez M, Akhtar AJ, Boyer JL. Drug-induced cholestasis. Hepatology (Baltimore, Md.) 2011, 53: 1377-87. PMID: 21480339, PMCID: PMC3089004, DOI: 10.1002/hep.24229.
- He H, Mennone A, Boyer JL, Cai SY. Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells. Hepatology (Baltimore, Md.) 2011, 53: 548-57. PMID: 21274875, PMCID: PMC3069505, DOI: 10.1002/hep.24047.
- Boyer JL. It's all about bile. Hepatology (Baltimore, Md.) 2009, 49: 711-23. PMID: 19242972, DOI: 10.1002/hep.22719.
- Cai SY, Gautam S, Nguyen T, Soroka CJ, Rahner C, Boyer JL. ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained. Gastroenterology 2009, 136: 1060-9. PMID: 19027009, PMCID: PMC3439851, DOI: 10.1053/j.gastro.2008.10.025.
- Cai SY, Wang L, Ballatori N, Boyer JL. Bile salt export pump is highly conserved during vertebrate evolution and its expression is inhibited by PFIC type II mutations. American Journal Of Physiology. Gastrointestinal And Liver Physiology 2001, 281: G316-22. PMID: 11447010, DOI: 10.1152/ajpgi.2001.281.2.G316.
- Yale Digestive DiseasesTemple Medical Center40 Temple Street, Ste Suite 1ANew Haven, CT 06510
- Yale Digestive DiseasesYale New Haven Hospital20 York StreetNew Haven, CT 06510
- Yale Digestive DiseasesTemple Medical Center40 Temple Street, Ste Suite 1ANew Haven, CT 06510
- Yale Digestive DiseasesYale New Haven Hospital20 York StreetNew Haven, CT 06510