- Yale New Haven Hospital20 York StreetNew Haven, CT 06510
Erol Fikrig, MD, BA
Internal Medicine, Infectious Diseases
Telehealth is available
Patient type treated
Adult
Accepting new patients
No
Referral required
Not Applicable
Board Certified in
Internal Medicine
Titles
- Waldemar Von Zedtwitz Professor of Medicine (Infectious Diseases) and Professor of Epidemiology (Microbial Diseases) and of Microbial Pathogenesis
- Affiliated Faculty, Yale Institute for Global Health
- Section Chief, Infectious Diseases
Education & Training
- MDCornell University (1985)
- BACornell University (1981)
- ResidentVanderbilt University Hospital
- FellowYale University School of Medicine
Additional Information
Board Certifications
- AB of Internal Medicine, Internal Medicine (1988)
Publications
- Arora G, Lynn GE, Tang X, Rosen CE, Hoornstra D, Sajid A, Hovius JW, Palm NW, Ring AM, Fikrig E. CD55 Facilitates Immune Evasion by Borrelia crocidurae, an Agent of Relapsing Fever. MBio 2022, e0116122. PMID: 36036625, DOI: 10.1128/mbio.01161-22.
- Marin-Lopez A, Wang Y, Jiang J, Ledizet M, Fikrig E. Erratum to "AgBR1 and NeSt1 antisera protect mice from Aedes aegypti-borne Zika infection" [Vaccine 39(12) (2021) 1675-1679]. Vaccine 2022, 40: 5404-5405. PMID: 35907678, DOI: 10.1016/j.vaccine.2022.05.024.
- Lynn GE, Černý J, Kurokawa C, Diktaş H, Matias J, Sajid A, Arora G, DePonte K, Narasimhan S, Fikrig E. Immunization of guinea pigs with cement extract induces resistance against Ixodes scapularis ticks. Ticks And Tick-borne Diseases 2022, 13: 102017. PMID: 35963188, DOI: 10.1016/j.ttbdis.2022.102017.
- Arora G, Hart T, Fikrig E. Use of host lipids by the Lyme disease spirochete may lead to biomarkers. The Journal Of Clinical Investigation 2022, 132 PMID: 35289311, PMCID: PMC8920323, DOI: 10.1172/JCI158254.
- Tang X, Cao Y, Arora G, Hwang J, Sajid A, Brown CL, Mehta S, Marín-López A, Chuang YM, Wu MJ, Ma H, Pal U, Narasimhan S, Fikrig E. Correction: The Lyme disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector. ELife 2022, 11 PMID: 35179491, PMCID: PMC8856650, DOI: 10.7554/eLife.77794.
- Chuang YM, Tang XD, Fikrig E. A Mosquito AgTRIO Monoclonal Antibody Reduces Early Plasmodium Infection of Mice. Infection And Immunity 2022, 90: e0035921. PMID: 34724388, PMCID: PMC8788779, DOI: 10.1128/IAI.00359-21.
- Arora G, Sajid A, Chuang YM, Dong Y, Gupta A, Gambardella K, DePonte K, Almeras L, Dimopolous G, Fikrig E. Immunomodulation by Mosquito Salivary Protein AgSAP Contributes to Early Host Infection by Plasmodium. MBio 2021, 12: e0309121. PMID: 34903042, PMCID: PMC8669493, DOI: 10.1128/mBio.03091-21.
- Matias J, Kurokawa C, Sajid A, Narasimhan S, Arora G, Diktas H, Lynn GE, DePonte K, Pardi N, Valenzuela JG, Weissman D, Fikrig E. Tick immunity using mRNA, DNA and protein-based Salp14 delivery strategies. Vaccine 2021, 39: 7661-7668. PMID: 34862075, PMCID: PMC8671329, DOI: 10.1016/j.vaccine.2021.11.003.
- Sajid A, Matias J, Arora G, Kurokawa C, DePonte K, Tang X, Lynn G, Wu MJ, Pal U, Strank NO, Pardi N, Narasimhan S, Weissman D, Fikrig E. mRNA vaccination induces tick resistance and prevents transmission of the Lyme disease agent. Science Translational Medicine 2021, 13: eabj9827. PMID: 34788080, DOI: 10.1126/scitranslmed.abj9827.
- Tang X, Cao Y, Arora G, Hwang J, Sajid A, Brown CL, Mehta S, Marín-López A, Chuang YM, Wu MJ, Ma H, Pal U, Narasimhan S, Fikrig E. The Lyme disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector. ELife 2021, 10 PMID: 34783654, PMCID: PMC8639152, DOI: 10.7554/eLife.72568.
- Geng T, Yang D, Lin T, Harrison AG, Wang B, Torrance B, Wang K, Wang Y, Yang L, Haynes L, Cheng G, Vella AT, Fikrig E, Wang P. An Essential Role of UBXN3B in B Lymphopoiesis. BioRxiv : The Preprint Server For Biology 2021 PMID: 34462748, PMCID: PMC8404893, DOI: 10.1101/2021.03.04.433919.
- Trentelman JJA, Tomás-Cortázar J, Knorr S, Barriales D, Hajdusek O, Sima R, Ersoz JI, Narasimhan S, Fikrig E, Nijhof AM, Anguita J, Hovius JW. Probing an Ixodes ricinus salivary gland yeast surface display with tick-exposed human sera to identify novel candidates for an anti-tick vaccine. Scientific Reports 2021, 11: 15745. PMID: 34344917, PMCID: PMC8333314, DOI: 10.1038/s41598-021-92538-9.
- Chuang YM, Agunbiade TA, Tang XD, Freudzon M, Almeras L, Fikrig E. The Effects of A Mosquito Salivary Protein on Sporozoite Traversal of Host Cells. The Journal Of Infectious Diseases 2021, 224: 544-553. PMID: 33306099, PMCID: PMC8328219, DOI: 10.1093/infdis/jiaa759.
- Narasimhan S, Swei A, Abouneameh S, Pal U, Pedra JHF, Fikrig E. Grappling with the tick microbiome. Trends In Parasitology 2021, 37: 722-733. PMID: 33962878, PMCID: PMC8282638, DOI: 10.1016/j.pt.2021.04.004.
- Kitsou C, Fikrig E, Pal U. Tick host immunity: vector immunomodulation and acquired tick resistance. Trends In Immunology 2021, 42: 554-574. PMID: 34074602, DOI: 10.1016/j.it.2021.05.005.
- Geng T, Lin T, Yang D, Harrison AG, Vella AT, Fikrig E, Wang P. A Critical Role for STING Signaling in Limiting Pathogenesis of Chikungunya Virus. The Journal Of Infectious Diseases 2021, 223: 2186-2196. PMID: 33161431, PMCID: PMC8205639, DOI: 10.1093/infdis/jiaa694.
- Marin-Lopez A, Jiang J, Wang Y, Cao Y, MacNeil T, Hastings AK, Fikrig E. Aedes aegypti SNAP and a calcium transporter ATPase influence dengue virus dissemination. PLoS Neglected Tropical Diseases 2021, 15: e0009442. PMID: 34115766, PMCID: PMC8195420, DOI: 10.1371/journal.pntd.0009442.
- Narasimhan S, Kurokawa C, DeBlasio M, Matias J, Sajid A, Pal U, Lynn G, Fikrig E. Acquired tick resistance: The trail is hot. Parasite Immunology 2021, 43: e12808. PMID: 33187012, PMCID: PMC8058238, DOI: 10.1111/pim.12808.
- Marin-Lopez A, Wang Y, Jiang J, Ledizet M, Fikrig E. AgBR1 and NeSt1 antisera protect mice from Aedes aegypti-borne Zika infection. Vaccine 2021, 39: 1675-1679. PMID: 33622591, PMCID: PMC7990057, DOI: 10.1016/j.vaccine.2021.01.072.
- De S, Kitsou C, Sonenshine DE, Pedra JHF, Fikrig E, Kassis JA, Pal U. Epigenetic Regulation of Tick Biology and Vectorial Capacity. Trends In Genetics : TIG 2021, 37: 8-11. PMID: 33020021, PMCID: PMC8008791, DOI: 10.1016/j.tig.2020.09.012.
- Lynn GE, Diktas H, DePonte K, Fikrig E. Naturally Acquired Resistance to Ixodes scapularis Elicits Partial Immunity against Other Tick Vectors in a Laboratory Host. The American Journal Of Tropical Medicine And Hygiene 2021, 104: 175-183. PMID: 33258439, PMCID: PMC7790098, DOI: 10.4269/ajtmh.20-0776.
- Pal U, Kitsou C, Drecktrah D, Yaş ÖB, Fikrig E. Interactions Between Ticks and Lyme Disease Spirochetes. Current Issues In Molecular Biology 2021, 42: 113-144. PMID: 33289683, PMCID: PMC8045411, DOI: 10.21775/cimb.042.113.
- Černý J, Lynn G, DePonte K, Ledizet M, Narasimhan S, Fikrig E. Fractionation of tick saliva reveals proteins associated with the development of acquired resistance to Ixodes scapularis. Vaccine 2020, 38: 8121-8129. PMID: 33168347, DOI: 10.1016/j.vaccine.2020.10.087.
- Cao Y, Rosen C, Arora G, Gupta A, Booth CJ, Murfin KE, Cerny J, Marin Lopez A, Chuang YM, Tang X, Pal U, Ring A, Narasimhan S, Fikrig E. An Ixodes scapularis Protein Disulfide Isomerase Contributes to Borrelia burgdorferi Colonization of the Vector. Infection And Immunity 2020, 88 PMID: 32928964, PMCID: PMC7671890, DOI: 10.1128/IAI.00426-20.
- Lin T, Geng T, Harrison AG, Yang D, Vella AT, Fikrig E, Wang P. CXCL10 Signaling Contributes to the Pathogenesis of Arthritogenic Alphaviruses. Viruses 2020, 12 PMID: 33147869, PMCID: PMC7692144, DOI: 10.3390/v12111252.
- Kurokawa C, Narasimhan S, Vidyarthi A, Booth CJ, Mehta S, Meister L, Diktas H, Strank N, Lynn GE, DePonte K, Craft J, Fikrig E. Repeat tick exposure elicits distinct immune responses in guinea pigs and mice. Ticks And Tick-borne Diseases 2020, 11: 101529. PMID: 32993942, PMCID: PMC7530331, DOI: 10.1016/j.ttbdis.2020.101529.
- Gupta A, Arora G, Rosen CE, Kloos Z, Cao Y, Cerny J, Sajid A, Hoornstra D, Golovchenko M, Rudenko N, Munderloh U, Hovius JW, Booth CJ, Jacobs-Wagner C, Palm NW, Ring AM, Fikrig E. A human secretome library screen reveals a role for Peptidoglycan Recognition Protein 1 in Lyme borreliosis. PLoS Pathogens 2020, 16: e1009030. PMID: 33175909, PMCID: PMC7657531, DOI: 10.1371/journal.ppat.1009030.
- Yang L, Geng T, Yang G, Ma J, Wang L, Ketkar H, Yang D, Lin T, Hwang J, Zhu S, Wang Y, Dai J, You F, Cheng G, Vella AT, Flavell RA, Fikrig E, Wang P. Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice. Communications Biology 2020, 3: 556. PMID: 33033362, PMCID: PMC7545163, DOI: 10.1038/s42003-020-01285-6.
- Wang Y, Uraki R, Hwang J, Fikrig E. TRiC/CCT Complex, a Binding Partner of NS1 Protein, Supports the Replication of Zika Virus in Both Mammalians and Mosquitoes. Viruses 2020, 12 PMID: 32397176, PMCID: PMC7290343, DOI: 10.3390/v12050519.
- Narasimhan S, Kurokawa C, Diktas H, Strank NO, Černý J, Murfin K, Cao Y, Lynn G, Trentleman J, Wu MJ, DePonte K, Kantor F, Anguita J, Hovius J, Fikrig E. Ixodes scapularis saliva components that elicit responses associated with acquired tick-resistance. Ticks And Tick-borne Diseases 2020, 11: 101369. PMID: 31924502, PMCID: PMC7382422, DOI: 10.1016/j.ttbdis.2019.101369.
- Gomes-Solecki M, Arnaboldi PM, Backenson PB, Benach JL, Cooper CL, Dattwyler RJ, Diuk-Wasser M, Fikrig E, Hovius JW, Laegreid W, Lundberg U, Marconi RT, Marques AR, Molloy P, Narasimhan S, Pal U, Pedra JHF, Plotkin S, Rock DL, Rosa P, Telford SR, Tsao J, Yang XF, Schutzer SE. Protective Immunity and New Vaccines for Lyme Disease. Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America 2020, 70: 1768-1773. PMID: 31620776, PMCID: PMC7155782, DOI: 10.1093/cid/ciz872.
- Koetsveld J, Platonov AE, Kuleshov K, Wagemakers A, Hoornstra D, Ang W, Szekeres S, van Duijvendijk GLA, Fikrig E, Embers ME, Sprong H, Hovius JW. Borrelia miyamotoi infection leads to cross-reactive antibodies to the C6 peptide in mice and men. Clinical Microbiology And Infection : The Official Publication Of The European Society Of Clinical Microbiology And Infectious Diseases 2020, 26: 513.e1-513.e6. PMID: 31404672, DOI: 10.1016/j.cmi.2019.07.026.
- Wang Y, Marin-Lopez A, Jiang J, Ledizet M, Fikrig E. Vaccination with Aedes aegypti AgBR1 Delays Lethal Mosquito-Borne Zika Virus Infection in Mice. Vaccines 2020, 8 PMID: 32218189, PMCID: PMC7348886, DOI: 10.3390/vaccines8020145.
- Zhao Y, Amodio M, Vander Wyk B, Gerritsen B, Kumar MM, van Dijk D, Moon K, Wang X, Malawista A, Richards MM, Cahill ME, Desai A, Sivadasan J, Venkataswamy MM, Ravi V, Fikrig E, Kumar P, Kleinstein SH, Krishnaswamy S, Montgomery RR. Single cell immune profiling of dengue virus patients reveals intact immune responses to Zika virus with enrichment of innate immune signatures. PLoS Neglected Tropical Diseases 2020, 14: e0008112. PMID: 32150565, PMCID: PMC7082063, DOI: 10.1371/journal.pntd.0008112.
- Chuang YM, Freudzon M, Yang J, Dong Y, Dimopoulos G, Fikrig E. Anopheles gambiae Lacking AgTRIO Inefficiently Transmits Plasmodium berghei to Mice. Infection And Immunity 2019, 87 PMID: 31285253, PMCID: PMC6704594, DOI: 10.1128/IAI.00326-19.
- Hwang J, Wang Y, Fikrig E. Inhibition of Chikungunya Virus Replication in Primary Human Fibroblasts by Liver X Receptor Agonist. Antimicrobial Agents And Chemotherapy 2019, 63 PMID: 31307983, PMCID: PMC6709483, DOI: 10.1128/AAC.01220-19.
- Murfin KE, Kleinbard R, Aydin M, Salazar SA, Fikrig E. Borrelia burgdorferi chemotaxis toward tick protein Salp12 contributes to acquisition. Ticks And Tick-borne Diseases 2019, 10: 1124-1134. PMID: 31204044, PMCID: PMC7792743, DOI: 10.1016/j.ttbdis.2019.06.002.
- Hastings AK, Uraki R, Gaitsch H, Dhaliwal K, Stanley S, Sproch H, Williamson E, MacNeil T, Marin-Lopez A, Hwang J, Wang Y, Grover JR, Fikrig E. Aedes aegypti NeSt1 Protein Enhances Zika Virus Pathogenesis by Activating Neutrophils. Journal Of Virology 2019, 93 PMID: 30971475, PMCID: PMC6580965, DOI: 10.1128/JVI.00395-19.
- Uraki R, Hastings AK, Marin-Lopez A, Sumida T, Takahashi T, Grover JR, Iwasaki A, Hafler DA, Montgomery RR, Fikrig E. Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice. Nature Microbiology 2019, 4: 948-955. PMID: 30858571, PMCID: PMC6533137, DOI: 10.1038/s41564-019-0385-x.
- Wang D, Zhang Z, Cui S, Zhao Y, Craft S, Fikrig E, You F. ELF4 facilitates innate host defenses against Plasmodium by activating transcription of Pf4 and Ppbp. The Journal Of Biological Chemistry 2019, 294: 7787-7796. PMID: 30898878, PMCID: PMC6514618, DOI: 10.1074/jbc.RA118.006321.
- Hastings AK, Hastings K, Uraki R, Hwang J, Gaitsch H, Dhaliwal K, Williamson E, Fikrig E. Loss of the TAM Receptor Axl Ameliorates Severe Zika Virus Pathogenesis and Reduces Apoptosis in Microglia. IScience 2019, 13: 339-350. PMID: 30884311, PMCID: PMC6424058, DOI: 10.1016/j.isci.2019.03.003.
- Cao L, Yang G, Gao S, Jing C, Montgomery RR, Yin Y, Wang P, Fikrig E, You F. HIPK2 is necessary for type I interferon-mediated antiviral immunity. Science Signaling 2019, 12 PMID: 30890658, PMCID: PMC6893850, DOI: 10.1126/scisignal.aau4604.
- Schutzer SE, Body BA, Boyle J, Branson BM, Dattwyler RJ, Fikrig E, Gerald NJ, Gomes-Solecki M, Kintrup M, Ledizet M, Levin AE, Lewinski M, Liotta LA, Marques A, Mead PS, Mongodin EF, Pillai S, Rao P, Robinson WH, Roth KM, Schriefer ME, Slezak T, Snyder JL, Steere AC, Witkowski J, Wong SJ, Branda JA. Direct Diagnostic Tests for Lyme Disease. Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America 2019, 68: 1052-1057. PMID: 30307486, PMCID: PMC6399434, DOI: 10.1093/cid/ciy614.
- Coumou J, Wagemakers A, Narasimhan S, Schuijt TJ, Ersoz JI, Oei A, de Boer OJ, Roelofs JJTH, Fikrig E, Hovius JW. The role of Mannose Binding Lectin in the immune response against Borrelia burgdorferi sensu lato. Scientific Reports 2019, 9: 1431. PMID: 30723261, PMCID: PMC6363739, DOI: 10.1038/s41598-018-37922-8.
- Narasimhan S, Booth CJ, DePonte K, Wu MJ, Liang X, Mohanty S, Kantor F, Fikrig E. Host-specific expression of Ixodes scapularis salivary genes. Ticks And Tick-borne Diseases 2019, 10: 386-397. PMID: 30545615, DOI: 10.1016/j.ttbdis.2018.12.001.
- Marín-Lopez A, Calvo-Pinilla E, Moreno S, Utrilla-Trigo S, Nogales A, Brun A, Fikrig E, Ortego J. Modeling Arboviral Infection in Mice Lacking the Interferon Alpha/Beta Receptor. Viruses 2019, 11 PMID: 30625992, PMCID: PMC6356211, DOI: 10.3390/v11010035.
- Hwang J, Jiang A, Fikrig E. A potent prolyl tRNA synthetase inhibitor antagonizes Chikungunya and Dengue viruses. Antiviral Research 2019, 161: 163-168. PMID: 30521835, PMCID: PMC6345585, DOI: 10.1016/j.antiviral.2018.11.017.
- Uraki R, Hastings AK, Brackney DE, Armstrong PM, Fikrig E. AgBR1 antibodies delay lethal Aedes aegypti-borne West Nile virus infection in mice. NPJ Vaccines 2019, 4: 23. PMID: 31312526, PMCID: PMC6614468, DOI: 10.1038/s41541-019-0120-x.
- Hwang J, Jiang A, Fikrig E. Rev-erb Agonist Inhibits Chikungunya and O'nyong'nyong Virus Replication. Open Forum Infectious Diseases 2018, 5: ofy315. PMID: 30568983, PMCID: PMC6293476, DOI: 10.1093/ofid/ofy315.
- Shaw DK, Tate AT, Schneider DS, Levashina EA, Kagan JC, Pal U, Fikrig E, Pedra JHF. Vector Immunity and Evolutionary Ecology: The Harmonious Dissonance. Trends In Immunology 2018, 39: 862-873. PMID: 30301592, PMCID: PMC6218297, DOI: 10.1016/j.it.2018.09.003.
- Schleicher TR, Yang J, Freudzon M, Rembisz A, Craft S, Hamilton M, Graham M, Mlambo G, Tripathi AK, Li Y, Cresswell P, Sinnis P, Dimopoulos G, Fikrig E. A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission. Nature Communications 2018, 9: 2908. PMID: 30046053, PMCID: PMC6060088, DOI: 10.1038/s41467-018-05374-3.
- Baeza Garcia A, Siu E, Sun T, Exler V, Brito L, Hekele A, Otten G, Augustijn K, Janse CJ, Ulmer JB, Bernhagen J, Fikrig E, Geall A, Bucala R. Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection. Nature Communications 2018, 9: 2714. PMID: 30006528, PMCID: PMC6045615, DOI: 10.1038/s41467-018-05041-7.
- Heipertz EL, Harper J, Lopez CA, Fikrig E, Hughes ME, Walker WE. Circadian Rhythms Influence the Severity of Sepsis in Mice via a TLR2-Dependent, Leukocyte-Intrinsic Mechanism. Journal Of Immunology (Baltimore, Md. : 1950) 2018, 201: 193-201. PMID: 29760192, PMCID: PMC9351006, DOI: 10.4049/jimmunol.1701677.
- Yang L, Wang L, Ketkar H, Ma J, Yang G, Cui S, Geng T, Mordue DG, Fujimoto T, Cheng G, You F, Lin R, Fikrig E, Wang P. UBXN3B positively regulates STING-mediated antiviral immune responses. Nature Communications 2018, 9: 2329. PMID: 29899553, PMCID: PMC5998066, DOI: 10.1038/s41467-018-04759-8.
- Moss CE, Robson A, Fikrig E, Narasimhan S. Visualization of Microbiota in Tick Guts by Whole-mount In Situ Hybridization. Journal Of Visualized Experiments : JoVE 2018 PMID: 29912204, PMCID: PMC6101453, DOI: 10.3791/57758.
- Beloor J, Maes N, Ullah I, Uchil P, Jackson A, Fikrig E, Lee SK, Kumar P. Small Interfering RNA-Mediated Control of Virus Replication in the CNS Is Therapeutic and Enables Natural Immunity to West Nile Virus. Cell Host & Microbe 2018, 23: 549-556.e3. PMID: 29606496, PMCID: PMC6074029, DOI: 10.1016/j.chom.2018.03.001.
- Dragovic SM, Agunbiade TA, Freudzon M, Yang J, Hastings AK, Schleicher TR, Zhou X, Craft S, Chuang YM, Gonzalez F, Li Y, Hrebikova G, Tripathi A, Mlambo G, Almeras L, Ploss A, Dimopoulos G, Fikrig E. Immunization with AgTRIO, a Protein in Anopheles Saliva, Contributes to Protection against Plasmodium Infection in Mice. Cell Host & Microbe 2018, 23: 523-535.e5. PMID: 29649443, PMCID: PMC5998332, DOI: 10.1016/j.chom.2018.03.008.
- Branda JA, Body BA, Boyle J, Branson BM, Dattwyler RJ, Fikrig E, Gerald NJ, Gomes-Solecki M, Kintrup M, Ledizet M, Levin AE, Lewinski M, Liotta LA, Marques A, Mead PS, Mongodin EF, Pillai S, Rao P, Robinson WH, Roth KM, Schriefer ME, Slezak T, Snyder J, Steere AC, Witkowski J, Wong SJ, Schutzer SE. Advances in Serodiagnostic Testing for Lyme Disease Are at Hand. Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America 2018, 66: 1133-1139. PMID: 29228208, PMCID: PMC6019075, DOI: 10.1093/cid/cix943.
- Uraki R, Hastings AK, Gloria-Soria A, Powell JR, Fikrig E. Altered vector competence in an experimental mosquito-mouse transmission model of Zika infection. PLoS Neglected Tropical Diseases 2018, 12: e0006350. PMID: 29505571, PMCID: PMC5854422, DOI: 10.1371/journal.pntd.0006350.
- Silver AC, Buckley SM, Hughes ME, Hastings AK, Nitabach MN, Fikrig E. Daily oscillations in expression and responsiveness of Toll-like receptors in splenic immune cells. Heliyon 2018, 4: e00579. PMID: 29862343, PMCID: PMC5968137, DOI: 10.1016/j.heliyon.2018.e00579.
- Yockey LJ, Jurado KA, Arora N, Millet A, Rakib T, Milano KM, Hastings AK, Fikrig E, Kong Y, Horvath TL, Weatherbee S, Kliman HJ, Coyne CB, Iwasaki A. Type I interferons instigate fetal demise after Zika virus infection. Science Immunology 2018, 3 PMID: 29305462, PMCID: PMC6049088, DOI: 10.1126/sciimmunol.aao1680.
- Krause PJ, Carroll M, Fedorova N, Brancato J, Dumouchel C, Akosa F, Narasimhan S, Fikrig E, Lane RS. Human Borrelia miyamotoi infection in California: Serodiagnosis is complicated by multiple endemic Borrelia species. PloS One 2018, 13: e0191725. PMID: 29420552, PMCID: PMC5805228, DOI: 10.1371/journal.pone.0191725.
- Smith AA, Yang X, Fikrig E, Pal U. Artificial Infection of Ticks with Borrelia burgdorferi Using a Microinjection Method and Their Detection In Vivo Using Quantitative PCR Targeting flaB RNA. Methods In Molecular Biology (Clifton, N.J.) 2018, 1690: 105-114. PMID: 29032540, DOI: 10.1007/978-1-4939-7383-5_9.
- Du H, Cui S, Li Y, Yang G, Wang P, Fikrig E, You F. MiR-221 negatively regulates innate anti-viral response. PloS One 2018, 13: e0200385. PMID: 30089112, PMCID: PMC6082502, DOI: 10.1371/journal.pone.0200385.
- Narasimhan S, Schuijt TJ, Abraham NM, Rajeevan N, Coumou J, Graham M, Robson A, Wu MJ, Daffre S, Hovius JW, Fikrig E. Modulation of the tick gut milieu by a secreted tick protein favors Borrelia burgdorferi colonization. Nature Communications 2017, 8: 184. PMID: 28775250, PMCID: PMC5543126, DOI: 10.1038/s41467-017-00208-0.
- Abraham NM, Liu L, Jutras BL, Murfin K, Acar A, Yarovinsky TO, Sutton E, Heisig M, Jacobs-Wagner C, Fikrig E. A Tick Antivirulence Protein Potentiates Antibiotics against Staphylococcus aureus. Antimicrobial Agents And Chemotherapy 2017, 61 PMID: 28438938, PMCID: PMC5487661, DOI: 10.1128/AAC.00113-17.
- Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA. Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature 2017, 546: 667-670. PMID: 28636595, PMCID: PMC5787375, DOI: 10.1038/nature22967.
- Wang L, Yang L, Fikrig E, Wang P. An essential role of PI3K in the control of West Nile virus infection. Scientific Reports 2017, 7: 3724. PMID: 28623344, PMCID: PMC5473900, DOI: 10.1038/s41598-017-03912-5.
- Uraki R, Jurado KA, Hwang J, Szigeti-Buck K, Horvath TL, Iwasaki A, Fikrig E. Fetal Growth Restriction Caused by Sexual Transmission of Zika Virus in Mice. The Journal Of Infectious Diseases 2017, 215: 1720-1724. PMID: 28472297, PMCID: PMC5853330, DOI: 10.1093/infdis/jix204.
- Hastings AK, Fikrig E. Zika Virus and Sexual Transmission: A New Route of Transmission for Mosquito-borne Flaviviruses . The Yale Journal Of Biology And Medicine 2017, 90: 325-330. PMID: 28656018, PMCID: PMC5482308.
- Hastings AK, Yockey LJ, Jagger BW, Hwang J, Uraki R, Gaitsch HF, Parnell LA, Cao B, Mysorekar IU, Rothlin CV, Fikrig E, Diamond MS, Iwasaki A. TAM Receptors Are Not Required for Zika Virus Infection in Mice. Cell Reports 2017, 19: 558-568. PMID: 28423319, PMCID: PMC5485843, DOI: 10.1016/j.celrep.2017.03.058.
- Shaw DK, Wang X, Brown LJ, Chávez AS, Reif KE, Smith AA, Scott AJ, McClure EE, Boradia VM, Hammond HL, Sundberg EJ, Snyder GA, Liu L, DePonte K, Villar M, Ueti MW, de la Fuente J, Ernst RK, Pal U, Fikrig E, Pedra JH. Infection-derived lipids elicit an immune deficiency circuit in arthropods. Nature Communications 2017, 8: 14401. PMID: 28195158, PMCID: PMC5316886, DOI: 10.1038/ncomms14401.
- Simoni MK, Jurado KA, Abrahams VM, Fikrig E, Guller S. Zika virus infection of Hofbauer cells. American Journal Of Reproductive Immunology (New York, N.Y. : 1989) 2017, 77 PMID: 27966815, PMCID: PMC5299062, DOI: 10.1111/aji.12613.
- Hu Y, O'Boyle K, Auer J, Raju S, You F, Wang P, Fikrig E, Sutton RE. Multiple UBXN family members inhibit retrovirus and lentivirus production and canonical NFκΒ signaling by stabilizing IκBα. PLoS Pathogens 2017, 13: e1006187. PMID: 28152074, PMCID: PMC5308826, DOI: 10.1371/journal.ppat.1006187.
- Uraki R, Hwang J, Jurado KA, Householder S, Yockey LJ, Hastings AK, Homer RJ, Iwasaki A, Fikrig E. Zika virus causes testicular atrophy. Science Advances 2017, 3: e1602899. PMID: 28261663, PMCID: PMC5321463, DOI: 10.1126/sciadv.1602899.
- Abraham NM, Liu L, Jutras BL, Yadav AK, Narasimhan S, Gopalakrishnan V, Ansari JM, Jefferson KK, Cava F, Jacobs-Wagner C, Fikrig E. Pathogen-mediated manipulation of arthropod microbiota to promote infection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: E781-E790. PMID: 28096373, PMCID: PMC5293115, DOI: 10.1073/pnas.1613422114.
- Murfin KE, Fikrig E. Tick Bioactive Molecules as Novel Therapeutics: Beyond Vaccine Targets. Frontiers In Cellular And Infection Microbiology 2017, 7: 222. PMID: 28634573, PMCID: PMC5459892, DOI: 10.3389/fcimb.2017.00222.
- Acharya D, Wang P, Paul AM, Dai J, Gate D, Lowery JE, Stokic DS, Leis AA, Flavell RA, Town T, Fikrig E, Bai F. Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance. Journal Of Virology 2017, 91 PMID: 27795421, PMCID: PMC5165211, DOI: 10.1128/JVI.01529-16.
- Ansari JM, Abraham NM, Massaro J, Murphy K, Smith-Carpenter J, Fikrig E. Anti-Biofilm Activity of a Self-Aggregating Peptide against Streptococcus mutans. Frontiers In Microbiology 2017, 8: 488. PMID: 28392782, PMCID: PMC5364132, DOI: 10.3389/fmicb.2017.00488.
- Paul AM, Acharya D, Le L, Wang P, Stokic DS, Leis AA, Alexopoulou L, Town T, Flavell RA, Fikrig E, Bai F. TLR8 Couples SOCS-1 and Restrains TLR7-Mediated Antiviral Immunity, Exacerbating West Nile Virus Infection in Mice. Journal Of Immunology (Baltimore, Md. : 1950) 2016, 197: 4425-4435. PMID: 27798161, PMCID: PMC5123688, DOI: 10.4049/jimmunol.1600902.
- Troupin A, Londono-Renteria B, Conway MJ, Cloherty E, Jameson S, Higgs S, Vanlandingham DL, Fikrig E, Colpitts TM. A novel mosquito ubiquitin targets viral envelope protein for degradation and reduces virion production during dengue virus infection. Biochimica Et Biophysica Acta 2016, 1860: 1898-909. PMID: 27241849, PMCID: PMC4949077, DOI: 10.1016/j.bbagen.2016.05.033.
- Conway MJ, Londono-Renteria B, Troupin A, Watson AM, Klimstra WB, Fikrig E, Colpitts TM. Aedes aegypti D7 Saliva Protein Inhibits Dengue Virus Infection. PLoS Neglected Tropical Diseases 2016, 10: e0004941. PMID: 27632170, PMCID: PMC5025043, DOI: 10.1371/journal.pntd.0004941.
- Jurado KA, Simoni MK, Tang Z, Uraki R, Hwang J, Householder S, Wu M, Lindenbach BD, Abrahams VM, Guller S, Fikrig E. Zika virus productively infects primary human placenta-specific macrophages. JCI Insight 2016, 1 PMID: 27595140, PMCID: PMC5007065, DOI: 10.1172/jci.insight.88461.
- Wagemakers A, Koetsveld J, Narasimhan S, Wickel M, Deponte K, Bleijlevens B, Jahfari S, Sprong H, Karan LS, Sarksyan DS, van der Poll T, Bockenstedt LK, Bins AD, Platonov AE, Fikrig E, Hovius JW. Variable Major Proteins as Targets for Specific Antibodies against Borrelia miyamotoi. Journal Of Immunology (Baltimore, Md. : 1950) 2016, 196: 4185-95. PMID: 27076681, PMCID: PMC5008243, DOI: 10.4049/jimmunol.1600014.
- Hwang J, Jurado KA, Fikrig E. Genetics of War and Truce between Mosquitos and Emerging Viruses. Cell Host & Microbe 2016, 19: 583-7. PMID: 27173926, PMCID: PMC7063512, DOI: 10.1016/j.chom.2016.04.009.
- Coumou J, Narasimhan S, Trentelman JJ, Wagemakers A, Koetsveld J, Ersoz JI, Oei A, Fikrig E, Hovius JW. Ixodes scapularis dystroglycan-like protein promotes Borrelia burgdorferi migration from the gut. Journal Of Molecular Medicine (Berlin, Germany) 2016, 94: 361-70. PMID: 26594018, PMCID: PMC4803822, DOI: 10.1007/s00109-015-1365-0.
- Wang P, Zhu S, Yang L, Cui S, Pan W, Jackson R, Zheng Y, Rongvaux A, Sun Q, Yang G, Gao S, Lin R, You F, Flavell R, Fikrig E. Nlrp6 regulates intestinal antiviral innate immunity. Science (New York, N.Y.) 2015, 350: 826-30. PMID: 26494172, PMCID: PMC4927078, DOI: 10.1126/science.aab3145.
- Londono-Renteria B, Troupin A, Conway MJ, Vesely D, Ledizet M, Roundy CM, Cloherty E, Jameson S, Vanlandingham D, Higgs S, Fikrig E, Colpitts TM. Dengue Virus Infection of Aedes aegypti Requires a Putative Cysteine Rich Venom Protein. PLoS Pathogens 2015, 11: e1005202. PMID: 26491875, PMCID: PMC4619585, DOI: 10.1371/journal.ppat.1005202.
- Narasimhan S, Fikrig E. Tick microbiome: the force within. Trends In Parasitology 2015, 31: 315-23. PMID: 25936226, PMCID: PMC4492851, DOI: 10.1016/j.pt.2015.03.010.
- Walker WE, Kurscheid S, Joshi S, Lopez CA, Goh G, Choi M, Barakat L, Francis J, Fisher A, Kozal M, Zapata H, Shaw A, Lifton R, Sutton RE, Fikrig E. Increased Levels of Macrophage Inflammatory Proteins Result in Resistance to R5-Tropic HIV-1 in a Subset of Elite Controllers. Journal Of Virology 2015, 89: 5502-14. PMID: 25740989, PMCID: PMC4442529, DOI: 10.1128/JVI.00118-15.
- Qian F, Goel G, Meng H, Wang X, You F, Devine L, Raddassi K, Garcia MN, Murray KO, Bolen CR, Gaujoux R, Shen-Orr SS, Hafler D, Fikrig E, Xavier R, Kleinstein SH, Montgomery RR. Systems immunology reveals markers of susceptibility to West Nile virus infection. Clinical And Vaccine Immunology : CVI 2015, 22: 6-16. PMID: 25355795, PMCID: PMC4278927, DOI: 10.1128/CVI.00508-14.
- Heisig M, Mattessich S, Rembisz A, Acar A, Shapiro M, Booth CJ, Neelakanta G, Fikrig E. Frostbite protection in mice expressing an antifreeze glycoprotein. PloS One 2015, 10: e0116562. PMID: 25714402, PMCID: PMC4340617, DOI: 10.1371/journal.pone.0116562.
- Fikrig E, Turchick A, Czochor J. Vaccine development: how scientific collaboration and communication help prevent the spread of disease: an interview with Erol Fikrig, MD. The Yale Journal Of Biology And Medicine 2014, 87: 519-25. PMID: 25506284, PMCID: PMC4257037.
- Conway MJ, Colpitts TM, Fikrig E. Role of the Vector in Arbovirus Transmission. Annual Review Of Virology 2014, 1: 71-88. PMID: 26958715, PMCID: PMC7809425, DOI: 10.1146/annurev-virology-031413-085513.
- Heisig M, Abraham NM, Liu L, Neelakanta G, Mattessich S, Sultana H, Shang Z, Ansari JM, Killiam C, Walker W, Cooley L, Flavell RA, Agaisse H, Fikrig E. Antivirulence properties of an antifreeze protein. Cell Reports 2014, 9: 417-24. PMID: 25373896, PMCID: PMC4223805, DOI: 10.1016/j.celrep.2014.09.034.
- Li MW, Wang J, Zhao YO, Fikrig E. Innexin AGAP001476 is critical for mediating anti-Plasmodium responses in Anopheles mosquitoes. The Journal Of Biological Chemistry 2014, 289: 24885-97. PMID: 25035430, PMCID: PMC4155657, DOI: 10.1074/jbc.M114.554519.
- Narasimhan S, Coumou J, Schuijt TJ, Boder E, Hovius JW, Fikrig E. A tick gut protein with fibronectin III domains aids Borrelia burgdorferi congregation to the gut during transmission. PLoS Pathogens 2014, 10: e1004278. PMID: 25102051, PMCID: PMC4125277, DOI: 10.1371/journal.ppat.1004278.
- Seidman D, Ojogun N, Walker NJ, Mastronunzio J, Kahlon A, Hebert KS, Karandashova S, Miller DP, Tegels BK, Marconi RT, Fikrig E, Borjesson DL, Carlyon JA. Anaplasma phagocytophilum surface protein AipA mediates invasion of mammalian host cells. Cellular Microbiology 2014, 16: 1133-45. PMID: 24612118, PMCID: PMC4115035, DOI: 10.1111/cmi.12286.
- Krause PJ, Narasimhan S, Wormser GP, Barbour AG, Platonov AE, Brancato J, Lepore T, Dardick K, Mamula M, Rollend L, Steeves TK, Diuk-Wasser M, Usmani-Brown S, Williamson P, Sarksyan DS, Fikrig E, Fish D. Borrelia miyamotoi sensu lato seroreactivity and seroprevalence in the northeastern United States. Emerging Infectious Diseases 2014, 20: 1183-90. PMID: 24960072, PMCID: PMC4073859, DOI: 10.3201/eid2007.131587.
- Qian F, Thakar J, Yuan X, Nolan M, Murray KO, Lee WT, Wong SJ, Meng H, Fikrig E, Kleinstein SH, Montgomery RR. Immune markers associated with host susceptibility to infection with West Nile virus. Viral Immunology 2014, 27: 39-47. PMID: 24605787, PMCID: PMC3949440, DOI: 10.1089/vim.2013.0074.
- Juthani-Mehta M, Guo X, Shaw AC, Towle V, Ning Y, Wang X, Allore HG, Fikrig E, Montgomery RR. Innate Immune Responses in the Neutrophils of Community Dwelling and Nursing Home Elders. Journal Of Aging Science 2014, 2 PMID: 25750929, PMCID: PMC4348001, DOI: 10.4172/2329-8847.1000115.
- Narasimhan S, Rajeevan N, Liu L, Zhao YO, Heisig J, Pan J, Eppler-Epstein R, Deponte K, Fish D, Fikrig E. Gut microbiota of the tick vector Ixodes scapularis modulate colonization of the Lyme disease spirochete. Cell Host & Microbe 2014, 15: 58-71. PMID: 24439898, PMCID: PMC3905459, DOI: 10.1016/j.chom.2013.12.001.
- Conway MJ, Watson AM, Colpitts TM, Dragovic SM, Li Z, Wang P, Feitosa F, Shepherd DT, Ryman KD, Klimstra WB, Anderson JF, Fikrig E. Mosquito saliva serine protease enhances dissemination of dengue virus into the mammalian host. Journal Of Virology 2014, 88: 164-75. PMID: 24131723, PMCID: PMC3911723, DOI: 10.1128/JVI.02235-13.
- You F, Wang P, Yang L, Yang G, Zhao YO, Qian F, Walker W, Sutton R, Montgomery R, Lin R, Iwasaki A, Fikrig E. ELF4 is critical for induction of type I interferon and the host antiviral response. Nature Immunology 2013, 14: 1237-46. PMID: 24185615, PMCID: PMC3939855, DOI: 10.1038/ni.2756.
- Bobenchik AM, Witola WH, Augagneur Y, Nic Lochlainn L, Garg A, Pachikara N, Choi JY, Zhao YO, Usmani-Brown S, Lee A, Adjalley SH, Samanta S, Fidock DA, Voelker DR, Fikrig E, Ben Mamoun C. Plasmodium falciparum phosphoethanolamine methyltransferase is essential for malaria transmission. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 18262-7. PMID: 24145416, PMCID: PMC3831454, DOI: 10.1073/pnas.1313965110.
- Wang J, Zhang Y, Zhao YO, Li MW, Zhang L, Dragovic S, Abraham NM, Fikrig E. Anopheles gambiae circumsporozoite protein-binding protein facilitates plasmodium infection of mosquito salivary glands. The Journal Of Infectious Diseases 2013, 208: 1161-9. PMID: 23801601, PMCID: PMC3762383, DOI: 10.1093/infdis/jit284.
- Yang X, Hegde S, Shroder DY, Smith AA, Promnares K, Neelakanta G, Anderson JF, Fikrig E, Pal U. The lipoprotein La7 contributes to Borrelia burgdorferi persistence in ticks and their transmission to naïve hosts. Microbes And Infection / Institut Pasteur 2013, 15: 729-37. PMID: 23774694, PMCID: PMC3769513, DOI: 10.1016/j.micinf.2013.06.001.
- Hovius JW, de Wever B, Sohne M, Brouwer MC, Coumou J, Wagemakers A, Oei A, Knol H, Narasimhan S, Hodiamont CJ, Jahfari S, Pals ST, Horlings HM, Fikrig E, Sprong H, van Oers MH. A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe. Lancet 2013, 382: 658. PMID: 23953389, PMCID: PMC3987849, DOI: 10.1016/S0140-6736(13)61644-X.
- Schuijt TJ, Bakhtiari K, Daffre S, Deponte K, Wielders SJ, Marquart JA, Hovius JW, van der Poll T, Fikrig E, Bunce MW, Camire RM, Nicolaes GA, Meijers JC, van 't Veer C. Factor Xa activation of factor V is of paramount importance in initiating the coagulation system: lessons from a tick salivary protein. Circulation 2013, 128: 254-66. PMID: 23817575, PMCID: PMC3826089, DOI: 10.1161/CIRCULATIONAHA.113.003191.
- Qian F, Chung L, Zheng W, Bruno V, Alexander RP, Wang Z, Wang X, Kurscheid S, Zhao H, Fikrig E, Gerstein M, Snyder M, Montgomery RR. Identification of genes critical for resistance to infection by West Nile virus using RNA-Seq analysis. Viruses 2013, 5: 1664-81. PMID: 23881275, PMCID: PMC3738954, DOI: 10.3390/v5071664.
- Wang P, Yang L, Cheng G, Yang G, Xu Z, You F, Sun Q, Lin R, Fikrig E, Sutton RE. UBXN1 interferes with Rig-I-like receptor-mediated antiviral immune response by targeting MAVS. Cell Reports 2013, 3: 1057-70. PMID: 23545497, PMCID: PMC3707122, DOI: 10.1016/j.celrep.2013.02.027.
- Magnarelli LA, Williams SC, Norris SJ, Fikrig E. Serum antibodies to Borrelia burgdorferi, Anaplasma phagocytophilum, and Babesia microti in recaptured white-footed mice. Journal Of Wildlife Diseases 2013, 49: 294-302. PMID: 23568904, PMCID: PMC3712766, DOI: 10.7589/2012-06-172.
- Qian F, Bolen CR, Jing C, Wang X, Zheng W, Zhao H, Fikrig E, Bruce RD, Kleinstein SH, Montgomery RR. Impaired toll-like receptor 3-mediated immune responses from macrophages of patients chronically infected with hepatitis C virus. Clinical And Vaccine Immunology : CVI 2013, 20: 146-55. PMID: 23220997, PMCID: PMC3571267, DOI: 10.1128/CVI.00530-12.
- Ullmann AJ, Dolan MC, Sackal CA, Fikrig E, Piesman J, Zeidner NS. Immunization with adenoviral-vectored tick salivary gland proteins (SALPs) in a murine model of Lyme borreliosis. Ticks And Tick-borne Diseases 2013, 4: 160-3. PMID: 23141105, PMCID: PMC4306421, DOI: 10.1016/j.ttbdis.2012.08.006.
- Krause PJ, Narasimhan S, Wormser GP, Rollend L, Fikrig E, Lepore T, Barbour A, Fish D. Human Borrelia miyamotoi infection in the United States. The New England Journal Of Medicine 2013, 368: 291-3. PMID: 23323920, PMCID: PMC3934646, DOI: 10.1056/NEJMc1215469.
- Silver AC, Dunne DW, Zeiss CJ, Bockenstedt LK, Radolf JD, Salazar JC, Fikrig E. MyD88 deficiency markedly worsens tissue inflammation and bacterial clearance in mice infected with Treponema pallidum, the agent of syphilis. PloS One 2013, 8: e71388. PMID: 23940747, PMCID: PMC3734110, DOI: 10.1371/journal.pone.0071388.
- Narasimhan S, Perez O, Mootien S, DePonte K, Koski RA, Fikrig E, Ledizet M. Characterization of Ixophilin, a thrombin inhibitor from the gut of Ixodes scapularis. PloS One 2013, 8: e68012. PMID: 23874485, PMCID: PMC3706618, DOI: 10.1371/journal.pone.0068012.
- Kahlon A, Ojogun N, Ragland SA, Seidman D, Troese MJ, Ottens AK, Mastronunzio JE, Truchan HK, Walker NJ, Borjesson DL, Fikrig E, Carlyon JA. Anaplasma phagocytophilum Asp14 is an invasin that interacts with mammalian host cells via its C terminus to facilitate infection. Infection And Immunity 2013, 81: 65-79. PMID: 23071137, PMCID: PMC3536139, DOI: 10.1128/IAI.00932-12.
- Arjona A, Silver AC, Walker WE, Fikrig E. Immunity's fourth dimension: approaching the circadian-immune connection. Trends In Immunology 2012, 33: 607-12. PMID: 23000010, PMCID: PMC3712756, DOI: 10.1016/j.it.2012.08.007.
- Sukumaran B, Ogura Y, Pedra JH, Kobayashi KS, Flavell RA, Fikrig E. Receptor interacting protein-2 contributes to host defense against Anaplasma phagocytophilum infection. FEMS Immunology And Medical Microbiology 2012, 66: 211-9. PMID: 22747758, PMCID: PMC3530031, DOI: 10.1111/j.1574-695X.2012.01001.x.
- Ojogun N, Kahlon A, Ragland SA, Troese MJ, Mastronunzio JE, Walker NJ, Viebrock L, Thomas RJ, Borjesson DL, Fikrig E, Carlyon JA. Anaplasma phagocytophilum outer membrane protein A interacts with sialylated glycoproteins to promote infection of mammalian host cells. Infection And Immunity 2012, 80: 3748-60. PMID: 22907813, PMCID: PMC3486060, DOI: 10.1128/IAI.00654-12.
- Colpitts TM, Conway MJ, Montgomery RR, Fikrig E. West Nile Virus: biology, transmission, and human infection. Clinical Microbiology Reviews 2012, 25: 635-48. PMID: 23034323, PMCID: PMC3485754, DOI: 10.1128/CMR.00045-12.
- Liu L, Dai J, Zhao YO, Narasimhan S, Yang Y, Zhang L, Fikrig E. Ixodes scapularis JAK-STAT pathway regulates tick antimicrobial peptides, thereby controlling the agent of human granulocytic anaplasmosis. The Journal Of Infectious Diseases 2012, 206: 1233-41. PMID: 22859824, PMCID: PMC3448968, DOI: 10.1093/infdis/jis484.
- Sultana H, Neelakanta G, Foellmer HG, Montgomery RR, Anderson JF, Koski RA, Medzhitov RM, Fikrig E. Semaphorin 7A contributes to West Nile virus pathogenesis through TGF-β1/Smad6 signaling. Journal Of Immunology (Baltimore, Md. : 1950) 2012, 189: 3150-8. PMID: 22896629, PMCID: PMC3496209, DOI: 10.4049/jimmunol.1201140.
- Mastronunzio JE, Kurscheid S, Fikrig E. Postgenomic analyses reveal development of infectious Anaplasma phagocytophilum during transmission from ticks to mice. Journal Of Bacteriology 2012, 194: 2238-47. PMID: 22389475, PMCID: PMC3347074, DOI: 10.1128/JB.06791-11.
- Ouyang Z, Narasimhan S, Neelakanta G, Kumar M, Pal U, Fikrig E, Norgard MV. Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi. BMC Microbiology 2012, 12: 44. PMID: 22443136, PMCID: PMC3320556, DOI: 10.1186/1471-2180-12-44.
- Silver AC, Arjona A, Hughes ME, Nitabach MN, Fikrig E. Circadian expression of clock genes in mouse macrophages, dendritic cells, and B cells. Brain, Behavior, And Immunity 2012, 26: 407-13. PMID: 22019350, PMCID: PMC3336152, DOI: 10.1016/j.bbi.2011.10.001.
- Silver AC, Arjona A, Walker WE, Fikrig E. The circadian clock controls toll-like receptor 9-mediated innate and adaptive immunity. Immunity 2012, 36: 251-61. PMID: 22342842, PMCID: PMC3315694, DOI: 10.1016/j.immuni.2011.12.017.
- Qian F, Wang X, Zhang L, Chen S, Piecychna M, Allore H, Bockenstedt L, Malawista S, Bucala R, Shaw AC, Fikrig E, Montgomery RR. Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly. Aging Cell 2012, 11: 104-10. PMID: 22023165, PMCID: PMC3257374, DOI: 10.1111/j.1474-9726.2011.00759.x.
- Wang P, Bai F, Zenewicz LA, Dai J, Gate D, Cheng G, Yang L, Qian F, Yuan X, Montgomery RR, Flavell RA, Town T, Fikrig E. IL-22 signaling contributes to West Nile encephalitis pathogenesis. PloS One 2012, 7: e44153. PMID: 22952908, PMCID: PMC3429482, DOI: 10.1371/journal.pone.0044153.
- Neelakanta G, Hudson AM, Sultana H, Cooley L, Fikrig E. Expression of Ixodes scapularis antifreeze glycoprotein enhances cold tolerance in Drosophila melanogaster. PloS One 2012, 7: e33447. PMID: 22428051, PMCID: PMC3302814, DOI: 10.1371/journal.pone.0033447.
- Zhao YO, Kurscheid S, Zhang Y, Liu L, Zhang L, Loeliger K, Fikrig E. Enhanced survival of Plasmodium-infected mosquitoes during starvation. PloS One 2012, 7: e40556. PMID: 22808193, PMCID: PMC3393683, DOI: 10.1371/journal.pone.0040556.
- da Silva Voorham JM, Rodenhuis-Zybert IA, Ayala Nuñez NV, Colpitts TM, van der Ende-Metselaar H, Fikrig E, Diamond MS, Wilschut J, Smit JM. Antibodies against the envelope glycoprotein promote infectivity of immature dengue virus serotype 2. PloS One 2012, 7: e29957. PMID: 22431958, PMCID: PMC3303773, DOI: 10.1371/journal.pone.0029957.
- Magnarelli LA, Norris SJ, Fikrig E. Serum antibodies to whole-cell and recombinant antigens of Borrelia burgdorferi in cottontail rabbits. Journal Of Wildlife Diseases 2012, 48: 12-20. PMID: 22247369, PMCID: PMC3261588, DOI: 10.7589/0090-3558-48.1.12.
- Anderson JF, Main AJ, Cheng G, Ferrandino FJ, Fikrig E. Horizontal and vertical transmission of West Nile virus genotype NY99 by Culex salinarius and genotypes NY99 and WN02 by Culex tarsalis. The American Journal Of Tropical Medicine And Hygiene 2012, 86: 134-9. PMID: 22232464, PMCID: PMC3247122, DOI: 10.4269/ajtmh.2012.11-0473.
- Biswas S, Chang H, Sarkis PT, Fikrig E, Zhu Q, Marasco WA. Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV-1 envelope proteins are largely mediated via human CD5+ B cells. Immunology 2011, 134: 419-33. PMID: 22044090, PMCID: PMC3230796, DOI: 10.1111/j.1365-2567.2011.03501.x.
- Arjona A, Wang P, Montgomery RR, Fikrig E. Innate immune control of West Nile virus infection. Cellular Microbiology 2011, 13: 1648-58. PMID: 21790942, PMCID: PMC3196381, DOI: 10.1111/j.1462-5822.2011.01649.x.
- Liu L, Narasimhan S, Dai J, Zhang L, Cheng G, Fikrig E. Ixodes scapularis salivary gland protein P11 facilitates migration of Anaplasma phagocytophilum from the tick gut to salivary glands. EMBO Reports 2011, 12: 1196-203. PMID: 21921936, PMCID: PMC3207102, DOI: 10.1038/embor.2011.177.
- Colpitts TM, Rodenhuis-Zybert I, Moesker B, Wang P, Fikrig E, Smit JM. prM-antibody renders immature West Nile virus infectious in vivo. The Journal Of General Virology 2011, 92: 2281-2285. PMID: 21697345, PMCID: PMC3347797, DOI: 10.1099/vir.0.031427-0.
- Colpitts TM, Cox J, Vanlandingham DL, Feitosa FM, Cheng G, Kurscheid S, Wang P, Krishnan MN, Higgs S, Fikrig E. Alterations in the Aedes aegypti transcriptome during infection with West Nile, dengue and yellow fever viruses. PLoS Pathogens 2011, 7: e1002189. PMID: 21909258, PMCID: PMC3164632, DOI: 10.1371/journal.ppat.1002189.
- Schuijt TJ, Coumou J, Narasimhan S, Dai J, Deponte K, Wouters D, Brouwer M, Oei A, Roelofs JJ, van Dam AP, van der Poll T, Van't Veer C, Hovius JW, Fikrig E. A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent. Cell Host & Microbe 2011, 10: 136-46. PMID: 21843870, PMCID: PMC3170916, DOI: 10.1016/j.chom.2011.06.010.
- Colpitts TM, Cox J, Nguyen A, Feitosa F, Krishnan MN, Fikrig E. Use of a tandem affinity purification assay to detect interactions between West Nile and dengue viral proteins and proteins of the mosquito vector. Virology 2011, 417: 179-87. PMID: 21700306, PMCID: PMC3166580, DOI: 10.1016/j.virol.2011.06.002.
- Zhang L, Zhang Y, Adusumilli S, Liu L, Narasimhan S, Dai J, Zhao YO, Fikrig E. Molecular interactions that enable movement of the Lyme disease agent from the tick gut into the hemolymph. PLoS Pathogens 2011, 7: e1002079. PMID: 21695244, PMCID: PMC3111543, DOI: 10.1371/journal.ppat.1002079.
- Qian F, Wang X, Zhang L, Lin A, Zhao H, Fikrig E, Montgomery RR. Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus. The Journal Of Infectious Diseases 2011, 203: 1415-24. PMID: 21398396, PMCID: PMC3080893, DOI: 10.1093/infdis/jir048.
- van Burgel ND, Balmus NC, Fikrig E, van Dam AP. Infectivity of Borrelia burgdorferi sensu lato is unaltered in C3-deficient mice. Ticks And Tick-borne Diseases 2011, 2: 20-6. PMID: 21771533, DOI: 10.1016/j.ttbdis.2010.10.003.
- Schuijt TJ, Narasimhan S, Daffre S, DePonte K, Hovius JW, Van't Veer C, van der Poll T, Bakhtiari K, Meijers JC, Boder ET, van Dam AP, Fikrig E. Identification and characterization of Ixodes scapularis antigens that elicit tick immunity using yeast surface display. PloS One 2011, 6: e15926. PMID: 21246036, PMCID: PMC3016337, DOI: 10.1371/journal.pone.0015926.
- Sukumaran B, Mastronunzio JE, Narasimhan S, Fankhauser S, Uchil PD, Levy R, Graham M, Colpitts TM, Lesser CF, Fikrig E. Anaplasma phagocytophilum AptA modulates Erk1/2 signalling. Cellular Microbiology 2011, 13: 47-61. PMID: 20716207, PMCID: PMC3005019, DOI: 10.1111/j.1462-5822.2010.01516.x.
- Cheng G, Liu L, Wang P, Zhang Y, Zhao YO, Colpitts TM, Feitosa F, Anderson JF, Fikrig E. An in vivo transfection approach elucidates a role for Aedes aegypti thioester-containing proteins in flaviviral infection. PloS One 2011, 6: e22786. PMID: 21818390, PMCID: PMC3144946, DOI: 10.1371/journal.pone.0022786.
- Colpitts TM, Barthel S, Wang P, Fikrig E. Dengue virus capsid protein binds core histones and inhibits nucleosome formation in human liver cells. PloS One 2011, 6: e24365. PMID: 21909430, PMCID: PMC3164731, DOI: 10.1371/journal.pone.0024365.
- Schuijt TJ, Hovius JW, van der Poll T, van Dam AP, Fikrig E. Lyme borreliosis vaccination: the facts, the challenge, the future. Trends In Parasitology 2011, 27: 40-7. PMID: 20594913, DOI: 10.1016/j.pt.2010.06.006.
- Bai F, Kong KF, Dai J, Qian F, Zhang L, Brown CR, Fikrig E, Montgomery RR. A paradoxical role for neutrophils in the pathogenesis of West Nile virus. The Journal Of Infectious Diseases 2010, 202: 1804-12. PMID: 21050124, PMCID: PMC3053000, DOI: 10.1086/657416.
- Dai J, Narasimhan S, Zhang L, Liu L, Wang P, Fikrig E. Tick histamine release factor is critical for Ixodes scapularis engorgement and transmission of the lyme disease agent. PLoS Pathogens 2010, 6: e1001205. PMID: 21124826, PMCID: PMC2991271, DOI: 10.1371/journal.ppat.1001205.
- Wang P, Arjona A, Zhang Y, Sultana H, Dai J, Yang L, LeBlanc PM, Doiron K, Saleh M, Fikrig E. Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I. Nature Immunology 2010, 11: 912-9. PMID: 20818395, PMCID: PMC3712356, DOI: 10.1038/ni.1933.
- Cheng G, Cox J, Wang P, Krishnan MN, Dai J, Qian F, Anderson JF, Fikrig E. A C-type lectin collaborates with a CD45 phosphatase homolog to facilitate West Nile virus infection of mosquitoes. Cell 2010, 142: 714-25. PMID: 20797779, PMCID: PMC2954371, DOI: 10.1016/j.cell.2010.07.038.
- Pedra JH, Narasimhan S, Rendić D, DePonte K, Bell-Sakyi L, Wilson IB, Fikrig E. Fucosylation enhances colonization of ticks by Anaplasma phagocytophilum. Cellular Microbiology 2010, 12: 1222-34. PMID: 20331643, PMCID: PMC3250644, DOI: 10.1111/j.1462-5822.2010.01464.x.
- Demento SL, Bonafé N, Cui W, Kaech SM, Caplan MJ, Fikrig E, Ledizet M, Fahmy TM. TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitis. Journal Of Immunology (Baltimore, Md. : 1950) 2010, 185: 2989-97. PMID: 20660705, PMCID: PMC3753007, DOI: 10.4049/jimmunol.1000768.
- Neelakanta G, Sultana H, Fish D, Anderson JF, Fikrig E. Anaplasma phagocytophilum induces Ixodes scapularis ticks to express an antifreeze glycoprotein gene that enhances their survival in the cold. The Journal Of Clinical Investigation 2010, 120: 3179-90. PMID: 20739755, PMCID: PMC2929727, DOI: 10.1172/JCI42868.
- Sultana H, Neelakanta G, Kantor FS, Malawista SE, Fish D, Montgomery RR, Fikrig E. Anaplasma phagocytophilum induces actin phosphorylation to selectively regulate gene transcription in Ixodes scapularis ticks. The Journal Of Experimental Medicine 2010, 207: 1727-43. PMID: 20660616, PMCID: PMC2916137, DOI: 10.1084/jem.20100276.
- Magnarelli LA, Williams SC, Fikrig E. Seasonal prevalence of serum antibodies to whole cell and recombinant antigens of Borrelia burgdorferi and Anaplasma phagocytophilum in white-tailed deer in Connecticut. Journal Of Wildlife Diseases 2010, 46: 781-90. PMID: 20688684, DOI: 10.7589/0090-3558-46.3.781.
- Dunne DW, Shaw A, Bockenstedt LK, Allore HG, Chen S, Malawista SE, Leng L, Mizue Y, Piecychna M, Zhang L, Towle V, Bucala R, Montgomery RR, Fikrig E. Increased TLR4 expression and downstream cytokine production in immunosuppressed adults compared to non-immunosuppressed adults. PloS One 2010, 5: e11343. PMID: 20596538, PMCID: PMC2893205, DOI: 10.1371/journal.pone.0011343.
- Panda A, Qian F, Mohanty S, van Duin D, Newman FK, Zhang L, Chen S, Towle V, Belshe RB, Fikrig E, Allore HG, Montgomery RR, Shaw AC. Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. Journal Of Immunology (Baltimore, Md. : 1950) 2010, 184: 2518-27. PMID: 20100933, PMCID: PMC3867271, DOI: 10.4049/jimmunol.0901022.
- Adusumilli S, Booth CJ, Anguita J, Fikrig E. Passage through Ixodes scapularis ticks enhances the virulence of a weakly pathogenic isolate of Borrelia burgdorferi. Infection And Immunity 2010, 78: 138-44. PMID: 19822652, PMCID: PMC2798202, DOI: 10.1128/IAI.00470-09.
- Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ. The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell 2009, 139: 1243-54. PMID: 20064371, PMCID: PMC2824905, DOI: 10.1016/j.cell.2009.12.017.
- Dai J, Wang P, Adusumilli S, Booth CJ, Narasimhan S, Anguita J, Fikrig E. Antibodies against a tick protein, Salp15, protect mice from the Lyme disease agent. Cell Host & Microbe 2009, 6: 482-92. PMID: 19917502, PMCID: PMC2843562, DOI: 10.1016/j.chom.2009.10.006.
- Fikrig E, Narasimhan S, Neelakanta G, Pal U, Chen M, Flavell R. Toll-like receptors 1 and 2 heterodimers alter Borrelia burgdorferi gene expression in mice and ticks. The Journal Of Infectious Diseases 2009, 200: 1331-40. PMID: 19754309, PMCID: PMC2846271, DOI: 10.1086/605950.
- Bai F, Town T, Qian F, Wang P, Kamanaka M, Connolly TM, Gate D, Montgomery RR, Flavell RA, Fikrig E. IL-10 signaling blockade controls murine West Nile virus infection. PLoS Pathogens 2009, 5: e1000610. PMID: 19816558, PMCID: PMC2749443, DOI: 10.1371/journal.ppat.1000610.
- Panda A, Arjona A, Sapey E, Bai F, Fikrig E, Montgomery RR, Lord JM, Shaw AC. Human innate immunosenescence: causes and consequences for immunity in old age. Trends In Immunology 2009, 30: 325-33. PMID: 19541535, PMCID: PMC4067971, DOI: 10.1016/j.it.2009.05.004.
- Sultana H, Foellmer HG, Neelakanta G, Oliphant T, Engle M, Ledizet M, Krishnan MN, Bonafé N, Anthony KG, Marasco WA, Kaplan P, Montgomery RR, Diamond MS, Koski RA, Fikrig E. Fusion loop peptide of the West Nile virus envelope protein is essential for pathogenesis and is recognized by a therapeutic cross-reactive human monoclonal antibody. Journal Of Immunology (Baltimore, Md. : 1950) 2009, 183: 650-60. PMID: 19535627, PMCID: PMC3690769, DOI: 10.4049/jimmunol.0900093.
- Anthony KG, Bai F, Krishnan MN, Fikrig E, Koski RA. Effective siRNA targeting of the 3' untranslated region of the West Nile virus genome. Antiviral Research 2009, 82: 166-8. PMID: 19135091, DOI: 10.1016/j.antiviral.2008.12.007.
- Guo X, Booth CJ, Paley MA, Wang X, DePonte K, Fikrig E, Narasimhan S, Montgomery RR. Inhibition of neutrophil function by two tick salivary proteins. Infection And Immunity 2009, 77: 2320-9. PMID: 19332533, PMCID: PMC2687334, DOI: 10.1128/IAI.01507-08.
- Demento SL, Eisenbarth SC, Foellmer HG, Platt C, Caplan MJ, Mark Saltzman W, Mellman I, Ledizet M, Fikrig E, Flavell RA, Fahmy TM. Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy. Vaccine 2009, 27: 3013-21. PMID: 19428913, PMCID: PMC2695996, DOI: 10.1016/j.vaccine.2009.03.034.
- Hovius JW, Bijlsma MF, van der Windt GJ, Wiersinga WJ, Boukens BJ, Coumou J, Oei A, de Beer R, de Vos AF, van 't Veer C, van Dam AP, Wang P, Fikrig E, Levi MM, Roelofs JJ, van der Poll T. The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi. PLoS Pathogens 2009, 5: e1000447. PMID: 19461880, PMCID: PMC2678258, DOI: 10.1371/journal.ppat.1000447.
- Town T, Bai F, Wang T, Kaplan AT, Qian F, Montgomery RR, Anderson JF, Flavell RA, Fikrig E. Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. Immunity 2009, 30: 242-53. PMID: 19200759, PMCID: PMC2707901, DOI: 10.1016/j.immuni.2008.11.012.
- Bonafé N, Rininger JA, Chubet RG, Foellmer HG, Fader S, Anderson JF, Bushmich SL, Anthony K, Ledizet M, Fikrig E, Koski RA, Kaplan P. A recombinant West Nile virus envelope protein vaccine candidate produced in Spodoptera frugiperda expresSF+ cells. Vaccine 2009, 27: 213-22. PMID: 18996430, PMCID: PMC2651515, DOI: 10.1016/j.vaccine.2008.10.046.
- Thomas V, Samanta S, Fikrig E. Anaplasma phagocytophilum increases cathepsin L activity, thereby globally influencing neutrophil function. Infection And Immunity 2008, 76: 4905-12. PMID: 18765732, PMCID: PMC2573316, DOI: 10.1128/IAI.00851-08.
- Hovius JW, Schuijt TJ, de Groot KA, Roelofs JJ, Oei GA, Marquart JA, de Beer R, van 't Veer C, van der Poll T, Ramamoorthi N, Fikrig E, van Dam AP. Preferential protection of Borrelia burgdorferi sensu stricto by a Salp15 homologue in Ixodes ricinus saliva. The Journal Of Infectious Diseases 2008, 198: 1189-97. PMID: 18752445, PMCID: PMC4317250, DOI: 10.1086/591917.
- Yang X, Izadi H, Coleman AS, Wang P, Ma Y, Fikrig E, Anguita J, Pal U. Borrelia burgdorferi lipoprotein BmpA activates pro-inflammatory responses in human synovial cells through a protein moiety. Microbes And Infection / Institut Pasteur 2008, 10: 1300-8. PMID: 18725314, PMCID: PMC2648844, DOI: 10.1016/j.micinf.2008.07.029.
- Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, Sultana H, Brass AL, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason PW, Koski RA, Elledge SJ, Xavier RJ, Agaisse H, Fikrig E. RNA interference screen for human genes associated with West Nile virus infection. Nature 2008, 455: 242-5. PMID: 18690214, PMCID: PMC3136529, DOI: 10.1038/nature07207.
- Wang P, Dai J, Bai F, Kong KF, Wong SJ, Montgomery RR, Madri JA, Fikrig E. Matrix metalloproteinase 9 facilitates West Nile virus entry into the brain. Journal Of Virology 2008, 82: 8978-85. PMID: 18632868, PMCID: PMC2546894, DOI: 10.1128/JVI.00314-08.
- Kong KF, Delroux K, Wang X, Qian F, Arjona A, Malawista SE, Fikrig E, Montgomery RR. Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly. Journal Of Virology 2008, 82: 7613-23. PMID: 18508883, PMCID: PMC2493309, DOI: 10.1128/JVI.00618-08.
- Wang S, Welte T, McGargill M, Town T, Thompson J, Anderson JF, Flavell RA, Fikrig E, Hedrick SM, Wang T. Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis. Journal Of Immunology (Baltimore, Md. : 1950) 2008, 181: 2084-91. PMID: 18641347, PMCID: PMC2494872, DOI: 10.4049/jimmunol.181.3.2084.
- Schuijt TJ, Hovius JW, van Burgel ND, Ramamoorthi N, Fikrig E, van Dam AP. The tick salivary protein Salp15 inhibits the killing of serum-sensitive Borrelia burgdorferi sensu lato isolates. Infection And Immunity 2008, 76: 2888-94. PMID: 18426890, PMCID: PMC2446733, DOI: 10.1128/IAI.00232-08.
- Anderson JF, Main AJ, Delroux K, Fikrig E. Extrinsic incubation periods for horizontal and vertical transmission of West Nile virus by Culex pipiens pipiens (Diptera: Culicidae). Journal Of Medical Entomology 2008, 45: 445-51. PMID: 18533438, DOI: 10.1603/0022-2585(2008)45[445:eipfha]2.0.co;2.
- Dai J, Wang P, Bai F, Town T, Fikrig E. Icam-1 participates in the entry of west nile virus into the central nervous system. Journal Of Virology 2008, 82: 4164-8. PMID: 18256150, PMCID: PMC2292986, DOI: 10.1128/JVI.02621-07.
- Kong KF, Wang X, Anderson JF, Fikrig E, Montgomery RR. West nile virus attenuates activation of primary human macrophages. Viral Immunology 2008, 21: 78-82. PMID: 18355125, PMCID: PMC2666911, DOI: 10.1089/vim.2007.0072.
- Hovius JW, de Jong MA, den Dunnen J, Litjens M, Fikrig E, van der Poll T, Gringhuis SI, Geijtenbeek TB. Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization. PLoS Pathogens 2008, 4: e31. PMID: 18282094, PMCID: PMC2242833, DOI: 10.1371/journal.ppat.0040031.
- Hovius JW, Levi M, Fikrig E. Salivating for knowledge: potential pharmacological agents in tick saliva. PLoS Medicine 2008, 5: e43. PMID: 18271624, PMCID: PMC2235897, DOI: 10.1371/journal.pmed.0050043.
- Pal U, Wang P, Bao F, Yang X, Samanta S, Schoen R, Wormser GP, Schwartz I, Fikrig E. Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis. The Journal Of Experimental Medicine 2008, 205: 133-41. PMID: 18166585, PMCID: PMC2234379, DOI: 10.1084/jem.20070962.
- Pedra JH, Mattner J, Tao J, Kerfoot SM, Davis RJ, Flavell RA, Askenase PW, Yin Z, Fikrig E. c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection. Infection And Immunity 2008, 76: 308-16. PMID: 17998313, PMCID: PMC2223674, DOI: 10.1128/IAI.00599-07.
- Pal U, Dai J, Li X, Neelakanta G, Luo P, Kumar M, Wang P, Yang X, Anderson JF, Fikrig E. A differential role for BB0365 in the persistence of Borrelia burgdorferi in mice and ticks. The Journal Of Infectious Diseases 2008, 197: 148-55. PMID: 18171298, DOI: 10.1086/523764.
- Arjona A, Ledizet M, Anthony K, Bonafé N, Modis Y, Town T, Fikrig E. West Nile virus envelope protein inhibits dsRNA-induced innate immune responses. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 179: 8403-9. PMID: 18056386, DOI: 10.4049/jimmunol.179.12.8403.
- Ledizet M, Kar K, Foellmer HG, Bonafé N, Anthony KG, Gould LH, Bushmich SL, Fikrig E, Koski RA. Antibodies targeting linear determinants of the envelope protein protect mice against West Nile virus. The Journal Of Infectious Diseases 2007, 196: 1741-8. PMID: 18190253, DOI: 10.1086/523654.
- Arjona A, Foellmer HG, Town T, Leng L, McDonald C, Wang T, Wong SJ, Montgomery RR, Fikrig E, Bucala R. Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion. The Journal Of Clinical Investigation 2007, 117: 3059-66. PMID: 17909632, PMCID: PMC1994625, DOI: 10.1172/JCI32218.
- Pedra JH, Sutterwala FS, Sukumaran B, Ogura Y, Qian F, Montgomery RR, Flavell RA, Fikrig E. ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 179: 4783-91. PMID: 17878377, DOI: 10.4049/jimmunol.179.7.4783.
- Hovius JW, Ramamoorthi N, Van't Veer C, de Groot KA, Nijhof AM, Jongejan F, van Dam AP, Fikrig E. Identification of Salp15 homologues in Ixodes ricinus ticks. Vector Borne And Zoonotic Diseases (Larchmont, N.Y.) 2007, 7: 296-303. PMID: 17896872, DOI: 10.1089/vbz.2006.0624.
- Li X, Neelakanta G, Liu X, Beck DS, Kantor FS, Fish D, Anderson JF, Fikrig E. Role of outer surface protein D in the Borrelia burgdorferi life cycle. Infection And Immunity 2007, 75: 4237-44. PMID: 17620358, PMCID: PMC1951184, DOI: 10.1128/IAI.00632-07.
- Hovius JW, van Dam AP, Fikrig E. Tick-host-pathogen interactions in Lyme borreliosis. Trends In Parasitology 2007, 23: 434-8. PMID: 17656156, DOI: 10.1016/j.pt.2007.07.001.
- Pedra JH, Tao J, Sutterwala FS, Sukumaran B, Berliner N, Bockenstedt LK, Flavell RA, Yin Z, Fikrig E. IL-12/23p40-dependent clearance of Anaplasma phagocytophilum in the murine model of human anaplasmosis. FEMS Immunology And Medical Microbiology 2007, 50: 401-10. PMID: 17521390, DOI: 10.1111/j.1574-695X.2007.00270.x.
- Tyson K, Elkins C, Patterson H, Fikrig E, de Silva A. Biochemical and functional characterization of Salp20, an Ixodes scapularis tick salivary protein that inhibits the complement pathway. Insect Molecular Biology 2007, 16: 469-79. PMID: 17651236, DOI: 10.1111/j.1365-2583.2007.00742.x.
- Narasimhan S, Sukumaran B, Bozdogan U, Thomas V, Liang X, DePonte K, Marcantonio N, Koski RA, Anderson JF, Kantor F, Fikrig E. A tick antioxidant facilitates the Lyme disease agent's successful migration from the mammalian host to the arthropod vector. Cell Host & Microbe 2007, 2: 7-18. PMID: 18005713, PMCID: PMC2699493, DOI: 10.1016/j.chom.2007.06.001.
- Thomas V, Fikrig E. Anaplasma phagocytophilum specifically induces tyrosine phosphorylation of ROCK1 during infection. Cellular Microbiology 2007, 9: 1730-7. PMID: 17346310, DOI: 10.1111/j.1462-5822.2007.00908.x.
- McDonald WF, Huleatt JW, Foellmer HG, Hewitt D, Tang J, Desai P, Price A, Jacobs A, Takahashi VN, Huang Y, Nakaar V, Alexopoulou L, Fikrig E, Powell TJ. A West Nile virus recombinant protein vaccine that coactivates innate and adaptive immunity. The Journal Of Infectious Diseases 2007, 195: 1607-17. PMID: 17471430, DOI: 10.1086/517613.
- Narasimhan S, Deponte K, Marcantonio N, Liang X, Royce TE, Nelson KF, Booth CJ, Koski B, Anderson JF, Kantor F, Fikrig E. Immunity against Ixodes scapularis salivary proteins expressed within 24 hours of attachment thwarts tick feeding and impairs Borrelia transmission. PloS One 2007, 2: e451. PMID: 17505544, PMCID: PMC1866177, DOI: 10.1371/journal.pone.0000451.
- Krishnan MN, Sukumaran B, Pal U, Agaisse H, Murray JL, Hodge TW, Fikrig E. Rab 5 is required for the cellular entry of dengue and West Nile viruses. Journal Of Virology 2007, 81: 4881-5. PMID: 17301152, PMCID: PMC1900185, DOI: 10.1128/JVI.02210-06.
- Neelakanta G, Li X, Pal U, Liu X, Beck DS, DePonte K, Fish D, Kantor FS, Fikrig E. Outer surface protein B is critical for Borrelia burgdorferi adherence and survival within Ixodes ticks. PLoS Pathogens 2007, 3: e33. PMID: 17352535, PMCID: PMC1817655, DOI: 10.1371/journal.ppat.0030033.
- Hovius JW, Li X, Ramamoorthi N, van Dam AP, Barthold SW, van der Poll T, Speelman P, Fikrig E. Coinfection with Borrelia burgdorferi sensu stricto and Borrelia garinii alters the course of murine Lyme borreliosis. FEMS Immunology And Medical Microbiology 2007, 49: 224-34. PMID: 17328756, DOI: 10.1111/j.1574-695X.2006.00177.x.
- Bai F, Town T, Pradhan D, Cox J, Ashish, Ledizet M, Anderson JF, Flavell RA, Krueger JK, Koski RA, Fikrig E. Antiviral peptides targeting the west nile virus envelope protein. Journal Of Virology 2007, 81: 2047-55. PMID: 17151121, PMCID: PMC1797586, DOI: 10.1128/JVI.01840-06.
- Li X, Pal U, Ramamoorthi N, Liu X, Desrosiers DC, Eggers CH, Anderson JF, Radolf JD, Fikrig E. The Lyme disease agent Borrelia burgdorferi requires BB0690, a Dps homologue, to persist within ticks. Molecular Microbiology 2007, 63: 694-710. PMID: 17181780, DOI: 10.1111/j.1365-2958.2006.05550.x.
- van Duin D, Mohanty S, Thomas V, Ginter S, Montgomery RR, Fikrig E, Allore HG, Medzhitov R, Shaw AC. Age-associated defect in human TLR-1/2 function. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 178: 970-5. PMID: 17202359, DOI: 10.4049/jimmunol.178.2.970.
- Garg R, Juncadella IJ, Ramamoorthi N, Ashish, Ananthanarayanan SK, Thomas V, Rincón M, Krueger JK, Fikrig E, Yengo CM, Anguita J. Cutting edge: CD4 is the receptor for the tick saliva immunosuppressor, Salp15. Journal Of Immunology (Baltimore, Md. : 1950) 2006, 177: 6579-83. PMID: 17082567, PMCID: PMC4302324, DOI: 10.4049/jimmunol.177.10.6579.
- Kanai R, Kar K, Anthony K, Gould LH, Ledizet M, Fikrig E, Marasco WA, Koski RA, Modis Y. Crystal structure of west nile virus envelope glycoprotein reveals viral surface epitopes. Journal Of Virology 2006, 80: 11000-8. PMID: 16943291, PMCID: PMC1642136, DOI: 10.1128/JVI.01735-06.
- Pedra JH, Narasimhan S, Deponte K, Marcantonio N, Kantor FS, Fikrig E. Disruption of the salivary protein 14 in Ixodes scapularis nymphs and impact on pathogen acquisition. The American Journal Of Tropical Medicine And Hygiene 2006, 75: 677-82. PMID: 17038693.
- Magnarelli LA, Stafford KC, Ijdo JW, Fikrig E. Antibodies to whole-cell or recombinant antigens of Borrelia burgdorferi, Anaplasma phagocytophilum, and Babesia microti in white-footed mice. Journal Of Wildlife Diseases 2006, 42: 732-8. PMID: 17255439, DOI: 10.7589/0090-3558-42.4.732.
- Wang T, Gao Y, Scully E, Davis CT, Anderson JF, Welte T, Ledizet M, Koski R, Madri JA, Barrett A, Yin Z, Craft J, Fikrig E. Gamma delta T cells facilitate adaptive immunity against West Nile virus infection in mice. Journal Of Immunology (Baltimore, Md. : 1950) 2006, 177: 1825-32. PMID: 16849493, DOI: 10.4049/jimmunol.177.3.1825.
- Sukumaran B, Narasimhan S, Anderson JF, DePonte K, Marcantonio N, Krishnan MN, Fish D, Telford SR, Kantor FS, Fikrig E. An Ixodes scapularis protein required for survival of Anaplasma phagocytophilum in tick salivary glands. The Journal Of Experimental Medicine 2006, 203: 1507-17. PMID: 16717118, PMCID: PMC2118316, DOI: 10.1084/jem.20060208.
- Shrestha B, Wang T, Samuel MA, Whitby K, Craft J, Fikrig E, Diamond MS. Gamma interferon plays a crucial early antiviral role in protection against West Nile virus infection. Journal Of Virology 2006, 80: 5338-48. PMID: 16699014, PMCID: PMC1472130, DOI: 10.1128/JVI.00274-06.
- Li X, Liu X, Beck DS, Kantor FS, Fikrig E. Borrelia burgdorferi lacking BBK32, a fibronectin-binding protein, retains full pathogenicity. Infection And Immunity 2006, 74: 3305-13. PMID: 16714558, PMCID: PMC1479267, DOI: 10.1128/IAI.02035-05.
- Fikrig E, Narasimhan S. Borrelia burgdorferi--traveling incognito? Microbes And Infection / Institut Pasteur 2006, 8: 1390-9. PMID: 16698304, DOI: 10.1016/j.micinf.2005.12.022.
- Carlyon JA, Fikrig E. Mechanisms of evasion of neutrophil killing by Anaplasma phagocytophilum. Current Opinion In Hematology 2006, 13: 28-33. PMID: 16319684, DOI: 10.1097/01.moh.0000190109.00532.56.
- Sukumaran B, Carlyon JA, Cai JL, Berliner N, Fikrig E. Early transcriptional response of human neutrophils to Anaplasma phagocytophilum infection. Infection And Immunity 2005, 73: 8089-99. PMID: 16299303, PMCID: PMC1307096, DOI: 10.1128/IAI.73.12.8089-8099.2005.
- Gould LH, Sui J, Foellmer H, Oliphant T, Wang T, Ledizet M, Murakami A, Noonan K, Lambeth C, Kar K, Anderson JF, de Silva AM, Diamond MS, Koski RA, Marasco WA, Fikrig E. Protective and therapeutic capacity of human single-chain Fv-Fc fusion proteins against West Nile virus. Journal Of Virology 2005, 79: 14606-13. PMID: 16282460, PMCID: PMC1287547, DOI: 10.1128/JVI.79.23.14606-14613.2005.
- Carlyon JA, Ryan D, Archer K, Fikrig E. Effects of Anaplasma phagocytophilum on host cell ferritin mRNA and protein levels. Infection And Immunity 2005, 73: 7629-36. PMID: 16239567, PMCID: PMC1273867, DOI: 10.1128/IAI.73.11.7629-7636.2005.
- Xu Q, Seemanapalli SV, Lomax L, McShan K, Li X, Fikrig E, Liang FT. Association of linear plasmid 28-1 with an arthritic phenotype of Borrelia burgdorferi. Infection And Immunity 2005, 73: 7208-15. PMID: 16239515, PMCID: PMC1273894, DOI: 10.1128/IAI.73.11.7208-7215.2005.
- Magnarelli LA, Bushmich SL, IJdo JW, Fikrig E. Seroprevalence of antibodies against Borrelia burgdorferi and Anaplasma phagocytophilum in cats. American Journal Of Veterinary Research 2005, 66: 1895-9. PMID: 16334946, DOI: 10.2460/ajvr.2005.66.1895.
- Magnarelli L, Fikrig E. Detection of antibodies to Borrelia burgdorferi in naturally infected horses in the USA by enzyme-linked immunosorbent assay using whole-cell and recombinant antigens. Research In Veterinary Science 2005, 79: 99-103. PMID: 15924926, DOI: 10.1016/j.rvsc.2004.11.009.
- Pedra JH, Sukumaran B, Carlyon JA, Berliner N, Fikrig E. Modulation of NB4 promyelocytic leukemic cell machinery by Anaplasma phagocytophilum. Genomics 2005, 86: 365-77. PMID: 16005178, DOI: 10.1016/j.ygeno.2005.05.008.
- Ramamoorthi N, Narasimhan S, Pal U, Bao F, Yang XF, Fish D, Anguita J, Norgard MV, Kantor FS, Anderson JF, Koski RA, Fikrig E. The Lyme disease agent exploits a tick protein to infect the mammalian host. Nature 2005, 436: 573-7. PMID: 16049492, PMCID: PMC4306560, DOI: 10.1038/nature03812.
- Ledizet M, Kar K, Foellmer HG, Wang T, Bushmich SL, Anderson JF, Fikrig E, Koski RA. A recombinant envelope protein vaccine against West Nile virus. Vaccine 2005, 23: 3915-24. PMID: 15917113, DOI: 10.1016/j.vaccine.2005.03.006.
- Bai F, Wang T, Pal U, Bao F, Gould LH, Fikrig E. Use of RNA interference to prevent lethal murine west nile virus infection. The Journal Of Infectious Diseases 2005, 191: 1148-54. PMID: 15747251, DOI: 10.1086/428507.
- Thomas V, Samanta S, Wu C, Berliner N, Fikrig E. Anaplasma phagocytophilum modulates gp91phox gene expression through altered interferon regulatory factor 1 and PU.1 levels and binding of CCAAT displacement protein. Infection And Immunity 2005, 73: 208-18. PMID: 15618156, PMCID: PMC538944, DOI: 10.1128/IAI.73.1.208-218.2005.
- Wang T, Town T, Alexopoulou L, Anderson JF, Fikrig E, Flavell RA. Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nature Medicine 2004, 10: 1366-73. PMID: 15558055, DOI: 10.1038/nm1140.
- Pal U, Li X, Wang T, Montgomery RR, Ramamoorthi N, Desilva AM, Bao F, Yang X, Pypaert M, Pradhan D, Kantor FS, Telford S, Anderson JF, Fikrig E. TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi. Cell 2004, 119: 457-68. PMID: 15537536, DOI: 10.1016/j.cell.2004.10.027.
- Wang T, Akkoyunlu M, Banerjee R, Fikrig E. Interferon-gamma deficiency reveals that 129Sv mice are inherently more susceptible to Anaplasma phagocytophilum than C57BL/6 mice. FEMS Immunology And Medical Microbiology 2004, 42: 299-305. PMID: 15477043, DOI: 10.1016/j.femsim.2004.06.001.
- Liang FT, Yan J, Mbow ML, Sviat SL, Gilmore RD, Mamula M, Fikrig E. Borrelia burgdorferi changes its surface antigenic expression in response to host immune responses. Infection And Immunity 2004, 72: 5759-67. PMID: 15385475, PMCID: PMC517580, DOI: 10.1128/IAI.72.10.5759-5767.2004.
- Liang FT, Brown EL, Wang T, Iozzo RV, Fikrig E. Protective niche for Borrelia burgdorferi to evade humoral immunity. The American Journal Of Pathology 2004, 165: 977-85. PMID: 15331421, PMCID: PMC1618599, DOI: 10.1016/S0002-9440(10)63359-7.
- Scorpio DG, Akkoyunlu M, Fikrig E, Dumler JS. CXCR2 blockade influences Anaplasma phagocytophilum propagation but not histopathology in the mouse model of human granulocytic anaplasmosis. Clinical And Diagnostic Laboratory Immunology 2004, 11: 963-8. PMID: 15358660, PMCID: PMC515272, DOI: 10.1128/CDLI.11.5.963-968.2004.
- Magnarelli LA, Bushmich SL, Sherman BA, Fikrig E. A comparison of serologic tests for the detection of serum antibodies to whole-cell and recombinant Borrelia burgdorferi antigens in cattle. The Canadian Veterinary Journal = La Revue Veterinaire Canadienne 2004, 45: 667-73. PMID: 15368740, PMCID: PMC546445.
- Carlyon JA, Abdel-Latif D, Pypaert M, Lacy P, Fikrig E. Anaplasma phagocytophilum utilizes multiple host evasion mechanisms to thwart NADPH oxidase-mediated killing during neutrophil infection. Infection And Immunity 2004, 72: 4772-83. PMID: 15271939, PMCID: PMC470610, DOI: 10.1128/IAI.72.8.4772-4783.2004.
- Wang T, Fikrig E. Immunity to West Nile virus. Current Opinion In Immunology 2004, 16: 519-23. PMID: 15245749, DOI: 10.1016/j.coi.2004.05.008.
- Liang FT, Caimano MJ, Radolf JD, Fikrig E. Borrelia burgdorferi outer surface protein (osp) B expression independent of ospA. Microbial Pathogenesis 2004, 37: 35-40. PMID: 15194158, DOI: 10.1016/j.micpath.2004.02.007.
- Gould LH, Fikrig E. West Nile virus: a growing concern? The Journal Of Clinical Investigation 2004, 113: 1102-7. PMID: 15085186, PMCID: PMC385414, DOI: 10.1172/JCI21623.
- Magnarelli LA, IJdo JW, Ramakrishnan U, Henderson DW, Stafford KC, Fikrig E. Use of recombinant antigens of Borrelia burgdorferi and Anaplasma phagocytophilum in enzyme-linked immunosorbent assays to detect antibodies in white-tailed deer. Journal Of Wildlife Diseases 2004, 40: 249-58. PMID: 15362824, DOI: 10.7589/0090-3558-40.2.249.
- Fikrig E, Pal U, Chen M, Anderson JF, Flavell RA. OspB antibody prevents Borrelia burgdorferi colonization of Ixodes scapularis. Infection And Immunity 2004, 72: 1755-9. PMID: 14977984, PMCID: PMC356050, DOI: 10.1128/iai.72.3.1755-1759.2004.
- Fikrig E, Coyle PK, Schutzer SE, Chen M, Deng Z, Flavell RA. Preferential presence of decorin-binding protein B (BBA25) and BBA50 antibodies in cerebrospinal fluid of patients with neurologic Lyme disease. Journal Of Clinical Microbiology 2004, 42: 1243-6. PMID: 15004083, PMCID: PMC356844, DOI: 10.1128/jcm.42.3.1243-1246.2004.
- Yang XF, Pal U, Alani SM, Fikrig E, Norgard MV. Essential role for OspA/B in the life cycle of the Lyme disease spirochete. The Journal Of Experimental Medicine 2004, 199: 641-8. PMID: 14981112, PMCID: PMC2213294, DOI: 10.1084/jem.20031960.
- Narasimhan S, Montgomery RR, DePonte K, Tschudi C, Marcantonio N, Anderson JF, Sauer JR, Cappello M, Kantor FS, Fikrig E. Disruption of Ixodes scapularis anticoagulation by using RNA interference. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 1141-6. PMID: 14745044, PMCID: PMC337020, DOI: 10.1073/pnas.0307669100.
- Pal U, Yang X, Chen M, Bockenstedt LK, Anderson JF, Flavell RA, Norgard MV, Fikrig E. OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands. The Journal Of Clinical Investigation 2004, 113: 220-30. PMID: 14722614, PMCID: PMC311436, DOI: 10.1172/JCI19894.
- Wong SJ, Demarest VL, Boyle RH, Wang T, Ledizet M, Kar K, Kramer LD, Fikrig E, Koski RA. Detection of human anti-flavivirus antibodies with a west nile virus recombinant antigen microsphere immunoassay. Journal Of Clinical Microbiology 2004, 42: 65-72. PMID: 14715733, PMCID: PMC321652, DOI: 10.1128/jcm.42.1.65-72.2004.
- Narasimhan S, Caimano MJ, Liang FT, Santiago F, Laskowski M, Philipp MT, Pachner AR, Radolf JD, Fikrig E. Borrelia burgdorferi transcriptome in the central nervous system of non-human primates. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 15953-8. PMID: 14671329, PMCID: PMC307674, DOI: 10.1073/pnas.2432412100.
- Carlyon JA, Fikrig E. Invasion and survival strategies of Anaplasma phagocytophilum. Cellular Microbiology 2003, 5: 743-54. PMID: 14531890, DOI: 10.1046/j.1462-5822.2003.00323.x.
- Carlyon JA, Akkoyunlu M, Xia L, Yago T, Wang T, Cummings RD, McEver RP, Fikrig E. Murine neutrophils require alpha1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum. Blood 2003, 102: 3387-95. PMID: 12869507, DOI: 10.1182/blood-2003-02-0621.
- Anguita J, Hedrick MN, Fikrig E. Adaptation of Borrelia burgdorferi in the tick and the mammalian host. FEMS Microbiology Reviews 2003, 27: 493-504. PMID: 14550942, DOI: 10.1016/S0168-6445(03)00036-6.
- Yago T, Leppänen A, Carlyon JA, Akkoyunlu M, Karmakar S, Fikrig E, Cummings RD, McEver RP. Structurally distinct requirements for binding of P-selectin glycoprotein ligand-1 and sialyl Lewis x to Anaplasma phagocytophilum and P-selectin. The Journal Of Biological Chemistry 2003, 278: 37987-97. PMID: 12847092, DOI: 10.1074/jbc.M305778200.
- Wang T, Scully E, Yin Z, Kim JH, Wang S, Yan J, Mamula M, Anderson JF, Craft J, Fikrig E. IFN-gamma-producing gamma delta T cells help control murine West Nile virus infection. Journal Of Immunology (Baltimore, Md. : 1950) 2003, 171: 2524-31. PMID: 12928402, DOI: 10.4049/jimmunol.171.5.2524.
- Wong SJ, Boyle RH, Demarest VL, Woodmansee AN, Kramer LD, Li H, Drebot M, Koski RA, Fikrig E, Martin DA, Shi PY. Immunoassay targeting nonstructural protein 5 to differentiate West Nile virus infection from dengue and St. Louis encephalitis virus infections and from flavivirus vaccination. Journal Of Clinical Microbiology 2003, 41: 4217-23. PMID: 12958248, PMCID: PMC193845, DOI: 10.1128/jcm.41.9.4217-4223.2003.
- Pal U, Fikrig E. Adaptation of Borrelia burgdorferi in the vector and vertebrate host. Microbes And Infection / Institut Pasteur 2003, 5: 659-66. PMID: 12787742, DOI: 10.1016/s1286-4579(03)00097-2.
- Welte T, Zhang SS, Wang T, Zhang Z, Hesslein DG, Yin Z, Kano A, Iwamoto Y, Li E, Craft JE, Bothwell AL, Fikrig E, Koni PA, Flavell RA, Fu XY. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 1879-84. PMID: 12571365, PMCID: PMC149927, DOI: 10.1073/pnas.0237137100.
- Schoen RT, Deshefy-Longhi T, Van-Hoecke C, Buscarino C, Fikrig E. An open-label, nonrandomized, single-center, prospective extension, clinical trial of booster dose schedules to assess the safety profile and immunogenicity of recombinant outer-surface protein A (OspA) Lyme disease vaccine. Clinical Therapeutics 2003, 25: 210-24. PMID: 12637121, DOI: 10.1016/s0149-2918(03)90027-0.
- Carlyon JA, Chan WT, Galán J, Roos D, Fikrig E. Repression of rac2 mRNA expression by Anaplasma phagocytophila is essential to the inhibition of superoxide production and bacterial proliferation. Journal Of Immunology (Baltimore, Md. : 1950) 2002, 169: 7009-18. PMID: 12471136, DOI: 10.4049/jimmunol.169.12.7009.
- Narasimhan S, Koski RA, Beaulieu B, Anderson JF, Ramamoorthi N, Kantor F, Cappello M, Fikrig E. A novel family of anticoagulants from the saliva of Ixodes scapularis. Insect Molecular Biology 2002, 11: 641-50. PMID: 12421422, DOI: 10.1046/j.1365-2583.2002.00375.x.
- Anguita J, Samanta S, Ananthanarayanan SK, Revilla B, Geba GP, Barthold SW, Fikrig E. Cyclooxygenase 2 activity modulates the severity of murine Lyme arthritis. FEMS Immunology And Medical Microbiology 2002, 34: 187-91. PMID: 12423770, PMCID: PMC4307933, DOI: 10.1111/j.1574-695X.2002.tb00623.x.
- IJdo JW, Wu C, Telford SR, Fikrig E. Differential expression of the p44 gene family in the agent of human granulocytic ehrlichiosis. Infection And Immunity 2002, 70: 5295-8. PMID: 12183586, PMCID: PMC128253, DOI: 10.1128/iai.70.9.5295-5298.2002.
- Alexopoulou L, Thomas V, Schnare M, Lobet Y, Anguita J, Schoen RT, Medzhitov R, Fikrig E, Flavell RA. Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nature Medicine 2002, 8: 878-84. PMID: 12091878, DOI: 10.1038/nm732.
- Magnarelli LA, Lawrenz M, Norris SJ, Fikrig E. Comparative reactivity of human sera to recombinant VlsE and other Borrelia burgdorferi antigens in class-specific enzyme-linked immunosorbent assays for Lyme borreliosis. Journal Of Medical Microbiology 2002, 51: 649-655. PMID: 12171295, DOI: 10.1099/0022-1317-51-8-649.
- Liang FT, Nelson FK, Fikrig E. Molecular adaptation of Borrelia burgdorferi in the murine host. The Journal Of Experimental Medicine 2002, 196: 275-80. PMID: 12119353, PMCID: PMC2193918, DOI: 10.1084/jem.20020770.
- Wang T, Malawista SE, Pal U, Grey M, Meek J, Akkoyunlu M, Thomas V, Fikrig E. Superoxide anion production during Anaplasma phagocytophila infection. The Journal Of Infectious Diseases 2002, 186: 274-80. PMID: 12134266, DOI: 10.1086/341451.
- Wang T, Magnarelli LA, Anderson JF, Gould LH, Bushmich SL, Wong SJ, Fikrig E. A recombinant envelope protein-based enzyme-linked immunosorbent assay for West Nile virus serodiagnosis. Vector Borne And Zoonotic Diseases (Larchmont, N.Y.) 2002, 2: 105-9. PMID: 12653304, DOI: 10.1089/153036602321131904.
- Anguita J, Barthold SW, Persinski R, Hedrick MN, Huy CA, Davis RJ, Flavell RA, Fikrig E. Murine Lyme arthritis development mediated by p38 mitogen-activated protein kinase activity. Journal Of Immunology (Baltimore, Md. : 1950) 2002, 168: 6352-7. PMID: 12055252, PMCID: PMC4309983, DOI: 10.4049/jimmunol.168.12.6352.
- Anguita J, Ramamoorthi N, Hovius JW, Das S, Thomas V, Persinski R, Conze D, Askenase PW, Rincón M, Kantor FS, Fikrig E. Salp15, an ixodes scapularis salivary protein, inhibits CD4(+) T cell activation. Immunity 2002, 16: 849-59. PMID: 12121666, DOI: 10.1016/s1074-7613(02)00325-4.
- Liang FT, Nelson FK, Fikrig E. DNA microarray assessment of putative Borrelia burgdorferi lipoprotein genes. Infection And Immunity 2002, 70: 3300-3. PMID: 12011030, PMCID: PMC128019, DOI: 10.1128/iai.70.6.3300-3303.2002.
- Narasimhan S, Santiago F, Koski RA, Brei B, Anderson JF, Fish D, Fikrig E. Examination of the Borrelia burgdorferi transcriptome in Ixodes scapularis during feeding. Journal Of Bacteriology 2002, 184: 3122-5. PMID: 12003955, PMCID: PMC135063, DOI: 10.1128/jb.184.11.3122-3125.2002.
- Magnarelli LA, Ijdo JW, Shermant BA, Bushmich SL, Levy SA, Fikrig E. Antibodies to granulocytic ehrlichiae in cattle from Connecticut. Journal Of Medical Microbiology 2002, 51: 326-331. PMID: 11926738, DOI: 10.1099/0022-1317-51-4-326.
- Thomas V, Fikrig E. The Lyme disease vaccine takes its toll. Vector Borne And Zoonotic Diseases (Larchmont, N.Y.) 2002, 2: 217-22. PMID: 12804162, DOI: 10.1089/153036602321653798.
- Wang T, Anderson JF, Magnarelli LA, Bushmich S, Wong S, Koski RA, Fikrig E. West Nile virus envelope protein: role in diagnosis and immunity. Annals Of The New York Academy Of Sciences 2001, 951: 325-7. PMID: 11797789.
- Wang T, Anderson JF, Magnarelli LA, Wong SJ, Koski RA, Fikrig E. Immunization of mice against West Nile virus with recombinant envelope protein. Journal Of Immunology (Baltimore, Md. : 1950) 2001, 167: 5273-7. PMID: 11673542, DOI: 10.4049/jimmunol.167.9.5273.
- Das S, Banerjee G, DePonte K, Marcantonio N, Kantor FS, Fikrig E. Salp25D, an Ixodes scapularis antioxidant, is 1 of 14 immunodominant antigens in engorged tick salivary glands. The Journal Of Infectious Diseases 2001, 184: 1056-64. PMID: 11574922, DOI: 10.1086/323351.
- Magnarelli LA, Levy SA, Ijdo JW, Wu C, Padula SJ, Fikrig E. Reactivity of dog sera to whole-cell or recombinant antigens of Borrelia burgdorferi by ELISA and immunoblot analysis. Journal Of Medical Microbiology 2001, 50: 889-895. PMID: 11599738, DOI: 10.1099/0022-1317-50-10-889.
- Anguita J, Thomas V, Samanta S, Persinski R, Hernanz C, Barthold SW, Fikrig E. Borrelia burgdorferi-induced inflammation facilitates spirochete adaptation and variable major protein-like sequence locus recombination. Journal Of Immunology (Baltimore, Md. : 1950) 2001, 167: 3383-90. PMID: 11544329, PMCID: PMC4309988, DOI: 10.4049/jimmunol.167.6.3383.
- Akkoyunlu M, Malawista SE, Anguita J, Fikrig E. Exploitation of interleukin-8-induced neutrophil chemotaxis by the agent of human granulocytic ehrlichiosis. Infection And Immunity 2001, 69: 5577-88. PMID: 11500432, PMCID: PMC98672, DOI: 10.1128/iai.69.9.5577-5588.2001.
- Magnarelli LA, Ijdo JW, Van Andel AE, Wu C, Oliver JH, Fikrig E. Reactivity of serum samples of dogs and horses tested by use of class-specific recombinant-based enzyme-linked immunosorbent assays for detection of granulocytic ehrlichiosis. American Journal Of Veterinary Research 2001, 62: 1365-9. PMID: 11560261, DOI: 10.2460/ajvr.2001.62.1365.
- De Martino SJ, Carlyon JA, Fikrig E. Coinfection with Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis. The New England Journal Of Medicine 2001, 345: 150-1. PMID: 11450674, DOI: 10.1056/NEJM200107123450218.
- Magnarelli L, Ijdo J, Wu C, Fikrig E. Recombinant protein-44-based class-specific enzyme-linked immunosorbent assays for serologic diagnosis of human granulocytic ehrlichiosis. European Journal Of Clinical Microbiology & Infectious Diseases : Official Publication Of The European Society Of Clinical Microbiology 2001, 20: 482-5. PMID: 11561804, DOI: 10.1007/s100960100542.
- Pal U, Montgomery RR, Lusitani D, Voet P, Weynants V, Malawista SE, Lobet Y, Fikrig E. Inhibition of Borrelia burgdorferi-tick interactions in vivo by outer surface protein A antibody. Journal Of Immunology (Baltimore, Md. : 1950) 2001, 166: 7398-403. PMID: 11390491, DOI: 10.4049/jimmunol.166.12.7398.
- Thomas V, Anguita J, Samanta S, Rosa PA, Stewart P, Barthold SW, Fikrig E. Dissociation of infectivity and pathogenicity in Borrelia burgdorferi. Infection And Immunity 2001, 69: 3507-9. PMID: 11292785, PMCID: PMC98321, DOI: 10.1128/IAI.69.5.3507-3509.2001.
- Thomas V, Anguita J, Barthold SW, Fikrig E. Coinfection with Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis alters murine immune responses, pathogen burden, and severity of Lyme arthritis. Infection And Immunity 2001, 69: 3359-71. PMID: 11292759, PMCID: PMC98295, DOI: 10.1128/IAI.69.5.3359-3371.2001.
- Tsao J, Barbour AG, Luke CJ, Fikrig E, Fish D. OspA immunization decreases transmission of Borrelia burgdorferi spirochetes from infected Peromyscus leucopus mice to larval Ixodes scapularis ticks. Vector Borne And Zoonotic Diseases (Larchmont, N.Y.) 2001, 1: 65-74. PMID: 12653137, DOI: 10.1089/153036601750137705.
- Magnarelli LA, Ijdo JW, Van Andel AE, Wu C, Fikrig E. Evaluation of a polyvalent enzyme-linked immunosorbent assay incorporating a recombinant p44 antigen for diagnosis of granulocytic ehrlichiosis in dogs and horses. American Journal Of Veterinary Research 2001, 62: 29-32. PMID: 11197555, DOI: 10.2460/ajvr.2001.62.29.
- Diehl S, Anguita J, Hoffmeyer A, Zapton T, Ihle JN, Fikrig E, Rincón M. Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1. Immunity 2000, 13: 805-15. PMID: 11163196, DOI: 10.1016/s1074-7613(00)00078-9.
- Ijdo JW, Wu C, Magnarelli LA, Stafford KC, Anderson JF, Fikrig E. Detection of Ehrlichia chaffeensis DNA in Amblyomma americanum ticks in Connecticut and Rhode Island. Journal Of Clinical Microbiology 2000, 38: 4655-6. PMID: 11101616, PMCID: PMC87657, DOI: 10.1128/JCM.38.12.4655-4656.2000.
- Magnarelli LA, Ijdo JW, Van Andel AE, Wu C, Padula SJ, Fikrig E. Serologic confirmation of Ehrlichia equi and Borrelia burgdorferi infections in horses from the northeastern United States. Journal Of The American Veterinary Medical Association 2000, 217: 1045-50. PMID: 11019714, DOI: 10.2460/javma.2000.217.1045.
- Pal U, de Silva AM, Montgomery RR, Fish D, Anguita J, Anderson JF, Lobet Y, Fikrig E. Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A. The Journal Of Clinical Investigation 2000, 106: 561-9. PMID: 10953031, PMCID: PMC380253, DOI: 10.1172/JCI9427.
- Granulocytic ehrlichiosis in mice deficient in phagocyte oxidase or inducible nitric oxide synthase.Banerjee R, Anguita J, Fikrig E. Granulocytic ehrlichiosis in mice deficient in phagocyte oxidase or inducible nitric oxide synthase. Infection And Immunity 2000, 68: 4361-2. PMID: 10858261, PMCID: PMC101771, DOI: 10.1128/iai.68.7.4361-4362.2000.
- Fikrig E, Feng W, Barthold SW, Telford SR, Flavell RA. Arthropod- and host-specific Borrelia burgdorferi bbk32 expression and the inhibition of spirochete transmission. Journal Of Immunology (Baltimore, Md. : 1950) 2000, 164: 5344-51. PMID: 10799897, DOI: 10.4049/jimmunol.164.10.5344.
- Magnarelli LA, Ijdo JW, Padula SJ, Flavell RA, Fikrig E. Serologic diagnosis of Lyme borreliosis by using enzyme-linked immunosorbent assays with recombinant antigens. Journal Of Clinical Microbiology 2000, 38: 1735-9. PMID: 10790090, PMCID: PMC86574, DOI: 10.1128/JCM.38.5.1735-1739.2000.
- Banerjee R, Anguita J, Roos D, Fikrig E. Cutting edge: infection by the agent of human granulocytic ehrlichiosis prevents the respiratory burst by down-regulating gp91phox. Journal Of Immunology (Baltimore, Md. : 1950) 2000, 164: 3946-9. PMID: 10754283, DOI: 10.4049/jimmunol.164.8.3946.
- IJdo JW, Meek JI, Cartter ML, Magnarelli LA, Wu C, Tenuta SW, Fikrig E, Ryder RW. The emergence of another tickborne infection in the 12-town area around Lyme, Connecticut: human granulocytic ehrlichiosis. The Journal Of Infectious Diseases 2000, 181: 1388-93. PMID: 10751139, DOI: 10.1086/315389.
- Akkoyunlu M, Fikrig E. Gamma interferon dominates the murine cytokine response to the agent of human granulocytic ehrlichiosis and helps to control the degree of early rickettsemia. Infection And Immunity 2000, 68: 1827-33. PMID: 10722570, PMCID: PMC97354, DOI: 10.1128/iai.68.4.1827-1833.2000.
- Anguita J, Samanta S, Revilla B, Suk K, Das S, Barthold SW, Fikrig E. Borrelia burgdorferi gene expression in vivo and spirochete pathogenicity. Infection And Immunity 2000, 68: 1222-30. PMID: 10678930, PMCID: PMC97271, DOI: 10.1128/iai.68.3.1222-1230.2000.
- Das S, Marcantonio N, Deponte K, Telford SR, Anderson JF, Kantor FS, Fikrig E. SALP16, a gene induced in Ixodes scapularis salivary glands during tick feeding. The American Journal Of Tropical Medicine And Hygiene 2000, 62: 99-105. PMID: 10761732, DOI: 10.4269/ajtmh.2000.62.99.
- IJdo JW, Wu C, Magnarelli LA, Fikrig E. Serodiagnosis of human granulocytic ehrlichiosis by a recombinant HGE-44-based enzyme-linked immunosorbent assay. Journal Of Clinical Microbiology 1999, 37: 3540-4. PMID: 10523549, PMCID: PMC85687, DOI: 10.1128/JCM.37.11.3540-3544.1999.
- Magnarelli LA, Van Andel AE, Ijdo JW, Heimer R, Fikrig E. Serologic testing of horses for granulocytic ehrlichiosis, using indirect fluorescent antibody staining and immunoblot analysis. American Journal Of Veterinary Research 1999, 60: 631-5. PMID: 10328436.
- van Dobbenburgh A, van Dam AP, Fikrig E. Human granulocytic ehrlichiosis in western Europe. The New England Journal Of Medicine 1999, 340: 1214-6. PMID: 10206853, DOI: 10.1056/NEJM199904153401517.
- Magnarelli LA, Ijdo JW, Stafford KC, Fikrig E. Infections of granulocytic ehrlichiae and Borrelia burgdorferi in white-tailed deer in Connecticut. Journal Of Wildlife Diseases 1999, 35: 266-74. PMID: 10231753, DOI: 10.7589/0090-3558-35.2.266.
- Magnarelli LA, Stafford KC, Ijdo JW, Fikrig E, Oliver JH, Hutcheson HJ, Boone JL. Antibodies to granulocytic ehrlichiae in white-footed and cotton mice in eastern United States. Journal Of Wildlife Diseases 1999, 35: 259-65. PMID: 10231752, DOI: 10.7589/0090-3558-35.2.259.
- Anguita J, Barthold SW, Samanta S, Ryan J, Fikrig E. Selective anti-inflammatory action of interleukin-11 in murine Lyme disease: arthritis decreases while carditis persists. The Journal Of Infectious Diseases 1999, 179: 734-7. PMID: 9952389, DOI: 10.1086/314613.
- Fikrig E, Chen M, Barthold SW, Anguita J, Feng W, Telford SR, Flavell RA. Borrelia burgdorferi erpT expression in the arthropod vector and murine host. Molecular Microbiology 1999, 31: 281-90. PMID: 9987129, DOI: 10.1046/j.1365-2958.1999.01171.x.
- Akin E, McHugh GL, Flavell RA, Fikrig E, Steere AC. The immunoglobulin (IgG) antibody response to OspA and OspB correlates with severe and prolonged Lyme arthritis and the IgG response to P35 correlates with mild and brief arthritis. Infection And Immunity 1999, 67: 173-81. PMID: 9864212, PMCID: PMC96293, DOI: 10.1128/IAI.67.1.173-181.1999.
- de Silva AM, Zeidner NS, Zhang Y, Dolan MC, Piesman J, Fikrig E. Influence of outer surface protein A antibody on Borrelia burgdorferi within feeding ticks. Infection And Immunity 1999, 67: 30-5. PMID: 9864192, PMCID: PMC96273, DOI: 10.1128/IAI.67.1.30-35.1999.
- Reactivity of human sera to different strains of granulocytic ehrlichiae in immunodiagnostic assays.Magnarelli LA, IJdo JW, Dumler JS, Heimer R, Fikrig E. Reactivity of human sera to different strains of granulocytic ehrlichiae in immunodiagnostic assays. The Journal Of Infectious Diseases 1998, 178: 1835-8. PMID: 9815246, DOI: 10.1086/314516.
- Anguita J, Rincón M, Samanta S, Barthold SW, Flavell RA, Fikrig E. Borrelia burgdorferi-infected, interleukin-6-deficient mice have decreased Th2 responses and increased lyme arthritis. The Journal Of Infectious Diseases 1998, 178: 1512-5. PMID: 9780277, DOI: 10.1086/314448.
- Magnarelli LA, Ijdo JW, Anderson JF, Padula SJ, Flavell RA, Fikrig E. Human exposure to a granulocytic Ehrlichia and other tick-borne agents in Connecticut. Journal Of Clinical Microbiology 1998, 36: 2823-7. PMID: 9738027, PMCID: PMC105071, DOI: 10.1128/JCM.36.10.2823-2827.1998.
- Fikrig E, Feng W, Aversa J, Schoen RT, Flavell RA. Differential expression of Borrelia burgdorferi genes during erythema migrans and Lyme arthritis. The Journal Of Infectious Diseases 1998, 178: 1198-201. PMID: 9806060, DOI: 10.1086/515684.
- Ijdo JW, Fikrig E. [Human granulocytic ehrlichiosis, a tick-borne disease]. Nederlands Tijdschrift Voor Geneeskunde 1998, 142: 1778-81. PMID: 9856144.
- Steere AC, Sikand VK, Meurice F, Parenti DL, Fikrig E, Schoen RT, Nowakowski J, Schmid CH, Laukamp S, Buscarino C, Krause DS. Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. Lyme Disease Vaccine Study Group. The New England Journal Of Medicine 1998, 339: 209-15. PMID: 9673298, DOI: 10.1056/NEJM199807233390401.
- Buitrago MI, Ijdo JW, Rinaudo P, Simon H, Copel J, Gadbaw J, Heimer R, Fikrig E, Bia FJ. Human granulocytic ehrlichiosis during pregnancy treated successfully with rifampin. Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America 1998, 27: 213-5. PMID: 9675481.
- Ijdo JW, Sun W, Zhang Y, Magnarelli LA, Fikrig E. Cloning of the gene encoding the 44-kilodalton antigen of the agent of human granulocytic ehrlichiosis and characterization of the humoral response. Infection And Immunity 1998, 66: 3264-9. PMID: 9632594, PMCID: PMC108341, DOI: 10.1128/IAI.66.7.3264-3269.1998.
- Nazario S, Das S, de Silva AM, Deponte K, Marcantonio N, Anderson JF, Fish D, Fikrig E, Kantor FS. Prevention of Borrelia burgdorferi transmission in guinea pigs by tick immunity. The American Journal Of Tropical Medicine And Hygiene 1998, 58: 780-5. PMID: 9660463, DOI: 10.4269/ajtmh.1998.58.780.
- Webster P, IJdo JW, Chicoine LM, Fikrig E. The agent of Human Granulocytic Ehrlichiosis resides in an endosomal compartment. The Journal Of Clinical Investigation 1998, 101: 1932-41. PMID: 9576758, PMCID: PMC508780, DOI: 10.1172/JCI1544.
- Das S, Deponte K, Marcantonio NL, Ijdo JW, Hodzic E, Katavolos P, Barthold SW, Telford SR, Kantor FS, Fikrig E. Granulocytic ehrlichiosis in tick-immune guinea pigs. Infection And Immunity 1998, 66: 1803-5. PMID: 9529119, PMCID: PMC108126, DOI: 10.1128/IAI.66.4.1803-1805.1998.
- Hodzic E, Ijdo JW, Feng S, Katavolos P, Sun W, Maretzki CH, Fish D, Fikrig E, Telford SR, Barthold SW. Granulocytic ehrlichiosis in the laboratory mouse. The Journal Of Infectious Diseases 1998, 177: 737-45. PMID: 9498456, DOI: 10.1086/514236.
- de Silva AM, Fikrig E, Hodzic E, Kantor FS, Telford SR, Barthold SW. Immune evasion by tickborne and host-adapted Borrelia burgdorferi. The Journal Of Infectious Diseases 1998, 177: 395-400. PMID: 9466527, DOI: 10.1086/514200.
- Ijdo JW, Zhang Y, Anderson ML, Goldberg D, Fikrig E. Heat shock protein 70 of the agent of human granulocytic ehrlichiosis binds to Borrelia burgdorferi antibodies. Clinical And Diagnostic Laboratory Immunology 1998, 5: 118-20. PMID: 9455892, PMCID: PMC121403.
- Sun W, IJdo JW, Telford SR, Hodzic E, Zhang Y, Barthold SW, Fikrig E. Immunization against the agent of human granulocytic ehrlichiosis in a murine model. The Journal Of Clinical Investigation 1997, 100: 3014-8. PMID: 9399947, PMCID: PMC508513, DOI: 10.1172/JCI119855.
- Fikrig E, Barthold SW, Chen M, Chang CH, Flavell RA. Protective antibodies develop, and murine Lyme arthritis regresses, in the absence of MHC class II and CD4+ T cells. Journal Of Immunology (Baltimore, Md. : 1950) 1997, 159: 5682-6. PMID: 9548512.
- Bockenstedt LK, Hodzic E, Feng S, Bourrel KW, de Silva A, Montgomery RR, Fikrig E, Radolf JD, Barthold SW. Borrelia burgdorferi strain-specific Osp C-mediated immunity in mice. Infection And Immunity 1997, 65: 4661-7. PMID: 9353047, PMCID: PMC175668.
- Magnarelli LA, Ijdo JW, Anderson JF, Madigan JE, Dumler JS, Fikrig E. Antibodies to Ehrlichia equi in dogs from the northeastern United States. Journal Of The American Veterinary Medical Association 1997, 211: 1134-7. PMID: 9364226.
- Anguita J, Samanta S, Barthold SW, Fikrig E. Ablation of interleukin-12 exacerbates Lyme arthritis in SCID mice. Infection And Immunity 1997, 65: 4334-6. PMID: 9317045, PMCID: PMC175621, DOI: 10.1128/IAI.65.10.4334-4336.1997.
- IJdo JW, Zhang Y, Hodzic E, Magnarelli LA, Wilson ML, Telford SR, Barthold SW, Fikrig E. The early humoral response in human granulocytic ehrlichiosis. The Journal Of Infectious Diseases 1997, 176: 687-92. PMID: 9291316, DOI: 10.1086/514091.
- de Silva AM, Fish D, Burkot TR, Zhang Y, Fikrig E. OspA antibodies inhibit the acquisition of Borrelia burgdorferi by Ixodes ticks. Infection And Immunity 1997, 65: 3146-50. PMID: 9234767, PMCID: PMC175444, DOI: 10.1128/IAI.65.8.3146-3150.1997.
- Anguita J, Roth R, Samanta S, Gee RJ, Barthold SW, Mamula M, Fikrig E. B7-1 and B7-2 monoclonal antibodies modulate the severity of murine Lyme arthritis. Infection And Immunity 1997, 65: 3037-41. PMID: 9234751, PMCID: PMC175428, DOI: 10.1128/IAI.65.8.3037-3041.1997.
- Barthold SW, Feng S, Bockenstedt LK, Fikrig E, Feen K. Protective and arthritis-resolving activity in sera of mice infected with Borrelia burgdorferi. Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America 1997, 25 Suppl 1: S9-17. PMID: 9233658, DOI: 10.1086/516166.
- De Silva AM, Fikrig E. Borrelia burgdorferi genes selectively expressed in ticks and mammals. Parasitology Today (Personal Ed.) 1997, 13: 267-70. PMID: 15275064, DOI: 10.1016/s0169-4758(97)01074-0.
- Brunet LR, Spielman A, Fikrig E, Telford SR. Heterogeneity of Lyme disease spirochaetes within individual vector ticks. Research In Microbiology 1997, 148: 437-45. PMID: 9765822, DOI: 10.1016/s0923-2508(97)83874-0.
- Fikrig E, Barthold SW, Sun W, Feng W, Telford SR, Flavell RA. Borrelia burgdorferi P35 and P37 proteins, expressed in vivo, elicit protective immunity. Immunity 1997, 6: 531-9. PMID: 9175831, DOI: 10.1016/s1074-7613(00)80341-6.
- Fikrig E, Barthold SW, Chen M, Tao H, Ali-Salaam P, Bockenstedt LK, Flavell RA. Lyme borreliosis in transgenic mice tolerant to OspA from Borrelia burgdorferi 25015. The Journal Of Infectious Diseases 1997, 175: 1000-3. PMID: 9086169, DOI: 10.1086/513958.
- Fikrig E, Barthold SW. Lyme disease in transgenic mice expressing the Borrelia burgdorferi flagellin epitope implicated in human neuroborreliosis. FEMS Microbiology Letters 1997, 148: 137-43. PMID: 9084140, DOI: 10.1111/j.1574-6968.1997.tb10279.x.
- Das S, Barthold SW, Giles SS, Montgomery RR, Telford SR, Fikrig E. Temporal pattern of Borrelia burgdorferi p21 expression in ticks and the mammalian host. The Journal Of Clinical Investigation 1997, 99: 987-95. PMID: 9062357, PMCID: PMC507907, DOI: 10.1172/JCI119264.
- Rincón M, Anguita J, Nakamura T, Fikrig E, Flavell RA. Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells. The Journal Of Experimental Medicine 1997, 185: 461-9. PMID: 9053446, PMCID: PMC2196041, DOI: 10.1084/jem.185.3.461.
- de Silva AM, Fikrig E. Arthropod- and host-specific gene expression by Borrelia burgdorferi. The Journal Of Clinical Investigation 1997, 99: 377-9. PMID: 9022068, PMCID: PMC507808, DOI: 10.1172/JCI119169.
- Magnarelli LA, Flavell RA, Padula SJ, Anderson JF, Fikrig E. Serologic diagnosis of canine and equine borreliosis: use of recombinant antigens in enzyme-linked immunosorbent assays. Journal Of Clinical Microbiology 1997, 35: 169-73. PMID: 8968901, PMCID: PMC229532, DOI: 10.1128/jcm.35.1.169-173.1997.
- Zhang YQ, Mathiesen D, Kolbert CP, Anderson J, Schoen RT, Fikrig E, Persing DH. Borrelia burgdorferi enzyme-linked immunosorbent assay for discrimination of OspA vaccination from spirochete infection. Journal Of Clinical Microbiology 1997, 35: 233-8. PMID: 8968914, PMCID: PMC229545, DOI: 10.1128/JCM.35.1.233-238.1997.
- Bockenstedt LK, Fikrig E, Barthold SW, Flavell RA, Kantor FS. Identification of a Borrelia burgdorferi OspA T cell epitope that promotes anti-OspA IgG in mice. Journal Of Immunology (Baltimore, Md. : 1950) 1996, 157: 5496-502. PMID: 8955199.
- Das S, Shraga D, Gannon C, Lam TT, Feng S, Brunet LR, Telford SR, Barthold SW, Flavell RA, Fikrig E. Characterization of a 30-kDa Borrelia burgdorferi substrate-binding protein homologue. Research In Microbiology 1996, 147: 739-51. PMID: 9296108, DOI: 10.1016/s0923-2508(97)85121-2.
- Feng S, Das S, Barthold SW, Fikrig E. Characterization of two genes, p11 and p5, on the Borrelia burgdorferi 49-kilo base linear plasmid. Biochimica Et Biophysica Acta 1996, 1307: 270-2. PMID: 8688460, DOI: 10.1016/0167-4781(96)00076-0.
- Fikrig E, Barthold SW, Chen M, Grewal IS, Craft J, Flavell RA. Protective antibodies in murine Lyme disease arise independently of CD40 ligand. Journal Of Immunology (Baltimore, Md. : 1950) 1996, 157: 1-3. PMID: 8683101.
- Anderson JF, Flavell RA, Magnarelli LA, Barthold SW, Kantor FS, Wallich R, Persing DH, Mathiesen D, Fikrig E. Novel Borrelia burgdorferi isolates from Ixodes scapularis and Ixodes dentatus ticks feeding on humans. Journal Of Clinical Microbiology 1996, 34: 524-9. PMID: 8904407, PMCID: PMC228839, DOI: 10.1128/jcm.34.3.524-529.1996.
- Anguita J, Persing DH, Rincon M, Barthold SW, Fikrig E. Effect of anti-interleukin 12 treatment on murine lyme borreliosis. The Journal Of Clinical Investigation 1996, 97: 1028-34. PMID: 8613525, PMCID: PMC507149, DOI: 10.1172/JCI118494.
- Magnarelli LA, Fikrig E, Padula SJ, Anderson JF, Flavell RA. Use of recombinant antigens of Borrelia burgdorferi in serologic tests for diagnosis of lyme borreliosis. Journal Of Clinical Microbiology 1996, 34: 237-40. PMID: 8788993, PMCID: PMC228775, DOI: 10.1128/jcm.34.2.237-240.1996.
- Feng S, Barthold SW, Telford SR, Fikrig E. P55, an immunogenic but nonprotective 55-kilodalton Borrelia burgdorferi protein in murine Lyme disease. Infection And Immunity 1996, 64: 363-5. PMID: 8557366, PMCID: PMC173770, DOI: 10.1128/IAI.64.1.363-365.1996.
- de Silva AM, Telford SR, Brunet LR, Barthold SW, Fikrig E. Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine. The Journal Of Experimental Medicine 1996, 183: 271-5. PMID: 8551231, PMCID: PMC2192397, DOI: 10.1084/jem.183.1.271.
- Fikrig E, Liu B, Fu LL, Das S, Smallwood JI, Flavell RA, Persing DH, Schoen RT, Barthold SW, Malawista SE. An ospA frame shift, identified from DNA in Lyme arthritis synovial fluid, results in an outer surface protein A that does not bind protective antibodies. Journal Of Immunology (Baltimore, Md. : 1950) 1995, 155: 5700-4. PMID: 7499856.
- Barthold SW, Levy SA, Fikrig E, Bockenstedt LK, Smith AL. Serologic responses of dogs naturally exposed to or vaccinated against Borrelia burgdorferi infection. Journal Of The American Veterinary Medical Association 1995, 207: 1435-40. PMID: 7493871.
- Schoen RT, Meurice F, Brunet CM, Cretella S, Krause DS, Craft JE, Fikrig E. Safety and immunogenicity of an outer surface protein A vaccine in subjects with previous Lyme disease. The Journal Of Infectious Diseases 1995, 172: 1324-9. PMID: 7594671, DOI: 10.1093/infdis/172.5.1324.
- Magnarelli LA, Dumler JS, Anderson JF, Johnson RC, Fikrig E. Coexistence of antibodies to tick-borne pathogens of babesiosis, ehrlichiosis, and Lyme borreliosis in human sera. Journal Of Clinical Microbiology 1995, 33: 3054-7. PMID: 8576376, PMCID: PMC228637, DOI: 10.1128/JCM.33.11.3054-3057.1995.
- Fikrig E, Tao H, Chen M, Barthold SW, Flavell RA. Lyme borreliosis in transgenic mice tolerant to Borrelia burgdorferi OspA or B. The Journal Of Clinical Investigation 1995, 96: 1706-14. PMID: 7560061, PMCID: PMC185806, DOI: 10.1172/JCI118215.
- De Silva AM, Fikrig E. Growth and migration of Borrelia burgdorferi in Ixodes ticks during blood feeding. The American Journal Of Tropical Medicine And Hygiene 1995, 53: 397-404. PMID: 7485694, DOI: 10.4269/ajtmh.1995.53.397.
- Jwang B, Dewing P, Fikrig E, Flavell RA. The hook protein of Borrelia burgdorferi, encoded by the flgE gene, is serologically recognized in Lyme disease. Clinical And Diagnostic Laboratory Immunology 1995, 2: 609-15. PMID: 8548542, PMCID: PMC170207, DOI: 10.1128/cdli.2.5.609-615.1995.
- Feng S, Das S, Lam T, Flavell RA, Fikrig E. A 55-kilodalton antigen encoded by a gene on a Borrelia burgdorferi 49-kilobase plasmid is recognized by antibodies in sera from patients with Lyme disease. Infection And Immunity 1995, 63: 3459-66. PMID: 7642278, PMCID: PMC173477, DOI: 10.1128/iai.63.9.3459-3466.1995.
- Cretella S, Gordon S, Flavell RA, Fikrig E. Evaluation of a Lyme disease enzyme immunoassay using the 41-G fragment of flagellin. European Journal Of Clinical Microbiology & Infectious Diseases : Official Publication Of The European Society Of Clinical Microbiology 1995, 14: 609-13. PMID: 7588849, DOI: 10.1007/BF01690736.
- Magnarelli LA, Anderson JF, Flavell RA, Fikrig E. Reactivity of white-footed mouse and raccoon sera to whole cell and recombinant antigens of Borrelia burgdorferi. Journal Of Wildlife Diseases 1995, 31: 339-44. PMID: 8592354, DOI: 10.7589/0090-3558-31.3.339.
- Feng S, Barthold SW, Bockenstedt LK, Zaller DM, Fikrig E. Lyme disease in human DR4Dw4-transgenic mice. The Journal Of Infectious Diseases 1995, 172: 286-9. PMID: 7797933, DOI: 10.1093/infdis/172.1.286.
- Barthold SW, Fikrig E, Bockenstedt LK, Persing DH. Circumvention of outer surface protein A immunity by host-adapted Borrelia burgdorferi. Infection And Immunity 1995, 63: 2255-61. PMID: 7768606, PMCID: PMC173294.
- Suk K, Das S, Sun W, Jwang B, Barthold SW, Flavell RA, Fikrig E. Borrelia burgdorferi genes selectively expressed in the infected host. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 4269-73. PMID: 7753795, PMCID: PMC41925, DOI: 10.1073/pnas.92.10.4269.
- Fikrig E, Tao H, Barthold SW, Flavell RA. Selection of variant Borrelia burgdorferi isolates from mice immunized with outer surface protein A or B. Infection And Immunity 1995, 63: 1658-62. PMID: 7729870, PMCID: PMC173206, DOI: 10.1128/iai.63.5.1658-1662.1995.
- Telford SR, Kantor FS, Lobet Y, Barthold SW, Spielman A, Flavell RA, Fikrig E. Efficacy of human Lyme disease vaccine formulations in a mouse model. The Journal Of Infectious Diseases 1995, 171: 1368-70. PMID: 7751719, DOI: 10.1093/infdis/171.5.1368.
- Dunne M, al-Ramadi BK, Barthold SW, Flavell RA, Fikrig E. Oral vaccination with an attenuated Salmonella typhimurium strain expressing Borrelia burgdorferi OspA prevents murine Lyme borreliosis. Infection And Immunity 1995, 63: 1611-4. PMID: 7890431, PMCID: PMC173199, DOI: 10.1128/iai.63.4.1611-1614.1995.
- Fikrig E, Telford SR, Wallich R, Chen M, Lobet Y, Matuschka FR, Kimsey RB, Kantor FS, Barthold SW, Spielman A, Flavell RA. Vaccination against Lyme disease caused by diverse Borrelia burgdorferi. The Journal Of Experimental Medicine 1995, 181: 215-21. PMID: 7807004, PMCID: PMC2191810, DOI: 10.1084/jem.181.1.215.
- McMillen MA, Cunningham ME, Schoen R, Fikrig E. Gout in patients with systemic lupus erythematosus. British Journal Of Rheumatology 1994, 33: 595-6. PMID: 8205413, DOI: 10.1093/rheumatology/33.6.595.
- Nguyen TP, Lam TT, Barthold SW, Telford SR, Flavell RA, Fikrig E. Partial destruction of Borrelia burgdorferi within ticks that engorged on OspE- or OspF-immunized mice. Infection And Immunity 1994, 62: 2079-84. PMID: 8168973, PMCID: PMC186469, DOI: 10.1128/iai.62.5.2079-2084.1994.
- Lam TT, Nguyen TP, Fikrig E, Flavell RA. A chromosomal Borrelia burgdorferi gene encodes a 22-kilodalton lipoprotein, P22, that is serologically recognized in Lyme disease. Journal Of Clinical Microbiology 1994, 32: 876-83. PMID: 8027338, PMCID: PMC263156, DOI: 10.1128/jcm.32.4.876-883.1994.
- Fikrig E, Bockenstedt LK, Barthold SW, Chen M, Tao H, Ali-Salaam P, Telford SR, Flavell RA. Sera from patients with chronic Lyme disease protect mice from Lyme borreliosis. The Journal Of Infectious Diseases 1994, 169: 568-74. PMID: 8158028, DOI: 10.1093/infdis/169.3.568.
- Persing DH, Rutledge BJ, Rys PN, Podzorski DS, Mitchell PD, Reed KD, Liu B, Fikrig E, Malawista SE. Target imbalance: disparity of Borrelia burgdorferi genetic material in synovial fluid from Lyme arthritis patients. The Journal Of Infectious Diseases 1994, 169: 668-72. PMID: 8158048, DOI: 10.1093/infdis/169.3.668.
- Roessner K, Fikrig E, Russell JQ, Cooper SM, Flavell RA, Budd RC. Prominent T lymphocyte response to Borrelia burgdorferi from peripheral blood of unexposed donors. European Journal Of Immunology 1994, 24: 320-4. PMID: 7905415, DOI: 10.1002/eji.1830240207.
- Lam TT, Nguyen TP, Montgomery RR, Kantor FS, Fikrig E, Flavell RA. Outer surface proteins E and F of Borrelia burgdorferi, the agent of Lyme disease. Infection And Immunity 1994, 62: 290-8. PMID: 8262642, PMCID: PMC186099, DOI: 10.1128/iai.62.1.290-298.1994.
- Fikrig E, Magnarelli LA, Chen M, Anderson JF, Flavell RA. Serologic analysis of dogs, horses, and cottontail rabbits for antibodies to an antigenic flagellar epitope of Borrelia burgdorferi. Journal Of Clinical Microbiology 1993, 31: 2451-5. PMID: 7691874, PMCID: PMC265777, DOI: 10.1128/jcm.31.9.2451-2455.1993.
- Telford SR, Fikrig E, Barthold SW, Brunet LR, Spielman A, Flavell RA. Protection against antigenically variable Borrelia burgdorferi conferred by recombinant vaccines. The Journal Of Experimental Medicine 1993, 178: 755-8. PMID: 8340764, PMCID: PMC2191140, DOI: 10.1084/jem.178.2.755.
- Bockenstedt LK, Fikrig E, Barthold SW, Kantor FS, Flavell RA. Inability of truncated recombinant Osp A proteins to elicit protective immunity to Borrelia burgdorferi in mice. Journal Of Immunology (Baltimore, Md. : 1950) 1993, 151: 900-6. PMID: 8335917.
- Fikrig E, Barthold SW, Flavell RA. OspA vaccination of mice with established Borrelia burgdorferi infection alters disease but not infection. Infection And Immunity 1993, 61: 2553-7. PMID: 8500891, PMCID: PMC280883, DOI: 10.1128/iai.61.6.2553-2557.1993.
- Fikrig E, Tao H, Kantor FS, Barthold SW, Flavell RA. Evasion of protective immunity by Borrelia burgdorferi by truncation of outer surface protein B. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 4092-6. PMID: 7683420, PMCID: PMC46452, DOI: 10.1073/pnas.90.9.4092.
- de Souza MS, Smith AL, Beck DS, Terwilliger GA, Fikrig E, Barthold SW. Long-term study of cell-mediated responses to Borrelia burgdorferi in the laboratory mouse. Infection And Immunity 1993, 61: 1814-22. PMID: 8478071, PMCID: PMC280770, DOI: 10.1128/IAI.61.5.1814-1822.1993.
- Fikrig E, Kantor FS, Barthold SW, Flavell RA. Protective immunity in lyme borreliosis. Parasitology Today (Personal Ed.) 1993, 9: 129-31. PMID: 15463734, DOI: 10.1016/0169-4758(93)90176-g.
- Comstock LE, Fikrig E, Shoberg RJ, Flavell RA, Thomas DD. A monoclonal antibody to OspA inhibits association of Borrelia burgdorferi with human endothelial cells. Infection And Immunity 1993, 61: 423-31. PMID: 7678585, PMCID: PMC302746, DOI: 10.1128/iai.61.2.423-431.1993.
- Fikrig E, Berland R, Chen M, Williams S, Sigal LH, Flavell RA. Serologic response to the Borrelia burgdorferi flagellin demonstrates an epitope common to a neuroblastoma cell line. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 183-7. PMID: 7678336, PMCID: PMC45624, DOI: 10.1073/pnas.90.1.183.
- Magnarelli LA, Fikrig E, Berland R, Anderson JF, Flavell RA. Comparison of whole-cell antibodies and an antigenic flagellar epitope of Borrelia burgdorferi in serologic tests for diagnosis of Lyme borreliosis. Journal Of Clinical Microbiology 1992, 30: 3158-62. PMID: 1280650, PMCID: PMC270607, DOI: 10.1128/jcm.30.12.3158-3162.1992.
- Simon M, Milward F, Lefebvre R, Schouls L, Fikrig E, Wasmoen T, Stover K, Menefee B, Robinson J. Spirochetes: vaccines, animal models and diagnostics. Research In Microbiology 1992, 143: 641-7. PMID: 1475524.
- Fikrig E, Telford SR, Barthold SW, Kantor FS, Spielman A, Flavell RA. Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 5418-21. PMID: 1608951, PMCID: PMC49303, DOI: 10.1073/pnas.89.12.5418.
- Fikrig E, Huguenel ED, Berland R, Rahn DW, Hardin JA, Flavell RA. Serologic diagnosis of Lyme disease using recombinant outer surface proteins A and B and flagellin. The Journal Of Infectious Diseases 1992, 165: 1127-32. PMID: 1583333, DOI: 10.1093/infdis/165.6.1127.
- Fikrig E, Barthold SW, Persing DH, Sun X, Kantor FS, Flavell RA. Borrelia burgdorferi strain 25015: characterization of outer surface protein A and vaccination against infection. Journal Of Immunology (Baltimore, Md. : 1950) 1992, 148: 2256-60. PMID: 1545130.
- de Souza MS, Fikrig E, Smith AL, Flavell RA, Barthold SW. Nonspecific proliferative responses of murine lymphocytes to Borrelia burgdorferi antigens. The Journal Of Infectious Diseases 1992, 165: 471-8. PMID: 1531672, DOI: 10.1093/infdis/165.3.471.
- Fikrig E, Barthold SW, Kantor FS, Flavell RA. Long-term protection of mice from Lyme disease by vaccination with OspA. Infection And Immunity 1992, 60: 773-7. PMID: 1541551, PMCID: PMC257553, DOI: 10.1128/iai.60.3.773-777.1992.
- Fikrig E, Barthold SW, Marcantonio N, Deponte K, Kantor FS, Flavell RA. Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice. Infection And Immunity 1992, 60: 657-61. PMID: 1730500, PMCID: PMC257680, DOI: 10.1128/iai.60.2.657-661.1992.
- Fikrig E, Barthold SW, Kantor FS, Flavell RA. Protection of mice from Lyme borreliosis by oral vaccination with Escherichia coli expressing OspA. The Journal Of Infectious Diseases 1991, 164: 1224-7. PMID: 1955724, DOI: 10.1093/infdis/164.6.1224.
- Berland R, Fikrig E, Rahn D, Hardin J, Flavell RA. Molecular characterization of the humoral response to the 41-kilodalton flagellar antigen of Borrelia burgdorferi, the Lyme disease agent. Infection And Immunity 1991, 59: 3531-5. PMID: 1894359, PMCID: PMC258917, DOI: 10.1128/iai.59.10.3531-3535.1991.
- Sears JE, Fikrig E, Nakagawa TY, Deponte K, Marcantonio N, Kantor FS, Flavell RA. Molecular mapping of Osp-A mediated immunity against Borrelia burgdorferi, the agent of Lyme disease. Journal Of Immunology (Baltimore, Md. : 1950) 1991, 147: 1995-2000. PMID: 1716290.
- Fikrig E, Barthold SW, Kantor FS, Flavell RA. Protection of mice against the Lyme disease agent by immunizing with recombinant OspA. Science (New York, N.Y.) 1990, 250: 553-6. PMID: 2237407, DOI: 10.1126/science.2237407.
- Fikrig E, Barg NL. Varicella associated intracerebral hemorrhage in the absence of thrombocytopenia. Diagnostic Microbiology And Infectious Disease 1989, 12: 357-9. PMID: 2591170, DOI: 10.1016/0732-8893(89)90103-x.
- Fikrig E, Worthington MT, Lefkowitz LB. Septic shock and acute respiratory distress syndrome after salpingitis caused by Streptococcus pyogenes group A. Southern Medical Journal 1989, 82: 634-5. PMID: 2655106, DOI: 10.1097/00007611-198905000-00024.
Patient Care Organizations
Titles
- Waldemar Von Zedtwitz Professor of Medicine (Infectious Diseases) and Professor of Epidemiology (Microbial Diseases) and of Microbial Pathogenesis
- Affiliated Faculty, Yale Institute for Global Health
- Section Chief, Infectious Diseases
Education & Training
- MDCornell University (1985)
- BACornell University (1981)
- ResidentVanderbilt University Hospital
- FellowYale University School of Medicine
Additional Information
Board Certifications
- AB of Internal Medicine, Internal Medicine (1988)
Publications
- Arora G, Lynn GE, Tang X, Rosen CE, Hoornstra D, Sajid A, Hovius JW, Palm NW, Ring AM, Fikrig E. CD55 Facilitates Immune Evasion by Borrelia crocidurae, an Agent of Relapsing Fever. MBio 2022, e0116122. PMID: 36036625, DOI: 10.1128/mbio.01161-22.
- Marin-Lopez A, Wang Y, Jiang J, Ledizet M, Fikrig E. Erratum to "AgBR1 and NeSt1 antisera protect mice from Aedes aegypti-borne Zika infection" [Vaccine 39(12) (2021) 1675-1679]. Vaccine 2022, 40: 5404-5405. PMID: 35907678, DOI: 10.1016/j.vaccine.2022.05.024.
- Lynn GE, Černý J, Kurokawa C, Diktaş H, Matias J, Sajid A, Arora G, DePonte K, Narasimhan S, Fikrig E. Immunization of guinea pigs with cement extract induces resistance against Ixodes scapularis ticks. Ticks And Tick-borne Diseases 2022, 13: 102017. PMID: 35963188, DOI: 10.1016/j.ttbdis.2022.102017.
- Arora G, Hart T, Fikrig E. Use of host lipids by the Lyme disease spirochete may lead to biomarkers. The Journal Of Clinical Investigation 2022, 132 PMID: 35289311, PMCID: PMC8920323, DOI: 10.1172/JCI158254.
- Tang X, Cao Y, Arora G, Hwang J, Sajid A, Brown CL, Mehta S, Marín-López A, Chuang YM, Wu MJ, Ma H, Pal U, Narasimhan S, Fikrig E. Correction: The Lyme disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector. ELife 2022, 11 PMID: 35179491, PMCID: PMC8856650, DOI: 10.7554/eLife.77794.
- Chuang YM, Tang XD, Fikrig E. A Mosquito AgTRIO Monoclonal Antibody Reduces Early Plasmodium Infection of Mice. Infection And Immunity 2022, 90: e0035921. PMID: 34724388, PMCID: PMC8788779, DOI: 10.1128/IAI.00359-21.
- Arora G, Sajid A, Chuang YM, Dong Y, Gupta A, Gambardella K, DePonte K, Almeras L, Dimopolous G, Fikrig E. Immunomodulation by Mosquito Salivary Protein AgSAP Contributes to Early Host Infection by Plasmodium. MBio 2021, 12: e0309121. PMID: 34903042, PMCID: PMC8669493, DOI: 10.1128/mBio.03091-21.
- Matias J, Kurokawa C, Sajid A, Narasimhan S, Arora G, Diktas H, Lynn GE, DePonte K, Pardi N, Valenzuela JG, Weissman D, Fikrig E. Tick immunity using mRNA, DNA and protein-based Salp14 delivery strategies. Vaccine 2021, 39: 7661-7668. PMID: 34862075, PMCID: PMC8671329, DOI: 10.1016/j.vaccine.2021.11.003.
- Sajid A, Matias J, Arora G, Kurokawa C, DePonte K, Tang X, Lynn G, Wu MJ, Pal U, Strank NO, Pardi N, Narasimhan S, Weissman D, Fikrig E. mRNA vaccination induces tick resistance and prevents transmission of the Lyme disease agent. Science Translational Medicine 2021, 13: eabj9827. PMID: 34788080, DOI: 10.1126/scitranslmed.abj9827.
- Tang X, Cao Y, Arora G, Hwang J, Sajid A, Brown CL, Mehta S, Marín-López A, Chuang YM, Wu MJ, Ma H, Pal U, Narasimhan S, Fikrig E. The Lyme disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector. ELife 2021, 10 PMID: 34783654, PMCID: PMC8639152, DOI: 10.7554/eLife.72568.
- Geng T, Yang D, Lin T, Harrison AG, Wang B, Torrance B, Wang K, Wang Y, Yang L, Haynes L, Cheng G, Vella AT, Fikrig E, Wang P. An Essential Role of UBXN3B in B Lymphopoiesis. BioRxiv : The Preprint Server For Biology 2021 PMID: 34462748, PMCID: PMC8404893, DOI: 10.1101/2021.03.04.433919.
- Trentelman JJA, Tomás-Cortázar J, Knorr S, Barriales D, Hajdusek O, Sima R, Ersoz JI, Narasimhan S, Fikrig E, Nijhof AM, Anguita J, Hovius JW. Probing an Ixodes ricinus salivary gland yeast surface display with tick-exposed human sera to identify novel candidates for an anti-tick vaccine. Scientific Reports 2021, 11: 15745. PMID: 34344917, PMCID: PMC8333314, DOI: 10.1038/s41598-021-92538-9.
- Chuang YM, Agunbiade TA, Tang XD, Freudzon M, Almeras L, Fikrig E. The Effects of A Mosquito Salivary Protein on Sporozoite Traversal of Host Cells. The Journal Of Infectious Diseases 2021, 224: 544-553. PMID: 33306099, PMCID: PMC8328219, DOI: 10.1093/infdis/jiaa759.
- Narasimhan S, Swei A, Abouneameh S, Pal U, Pedra JHF, Fikrig E. Grappling with the tick microbiome. Trends In Parasitology 2021, 37: 722-733. PMID: 33962878, PMCID: PMC8282638, DOI: 10.1016/j.pt.2021.04.004.
- Kitsou C, Fikrig E, Pal U. Tick host immunity: vector immunomodulation and acquired tick resistance. Trends In Immunology 2021, 42: 554-574. PMID: 34074602, DOI: 10.1016/j.it.2021.05.005.
- Geng T, Lin T, Yang D, Harrison AG, Vella AT, Fikrig E, Wang P. A Critical Role for STING Signaling in Limiting Pathogenesis of Chikungunya Virus. The Journal Of Infectious Diseases 2021, 223: 2186-2196. PMID: 33161431, PMCID: PMC8205639, DOI: 10.1093/infdis/jiaa694.
- Marin-Lopez A, Jiang J, Wang Y, Cao Y, MacNeil T, Hastings AK, Fikrig E. Aedes aegypti SNAP and a calcium transporter ATPase influence dengue virus dissemination. PLoS Neglected Tropical Diseases 2021, 15: e0009442. PMID: 34115766, PMCID: PMC8195420, DOI: 10.1371/journal.pntd.0009442.
- Narasimhan S, Kurokawa C, DeBlasio M, Matias J, Sajid A, Pal U, Lynn G, Fikrig E. Acquired tick resistance: The trail is hot. Parasite Immunology 2021, 43: e12808. PMID: 33187012, PMCID: PMC8058238, DOI: 10.1111/pim.12808.
- Marin-Lopez A, Wang Y, Jiang J, Ledizet M, Fikrig E. AgBR1 and NeSt1 antisera protect mice from Aedes aegypti-borne Zika infection. Vaccine 2021, 39: 1675-1679. PMID: 33622591, PMCID: PMC7990057, DOI: 10.1016/j.vaccine.2021.01.072.
- De S, Kitsou C, Sonenshine DE, Pedra JHF, Fikrig E, Kassis JA, Pal U. Epigenetic Regulation of Tick Biology and Vectorial Capacity. Trends In Genetics : TIG 2021, 37: 8-11. PMID: 33020021, PMCID: PMC8008791, DOI: 10.1016/j.tig.2020.09.012.
- Lynn GE, Diktas H, DePonte K, Fikrig E. Naturally Acquired Resistance to Ixodes scapularis Elicits Partial Immunity against Other Tick Vectors in a Laboratory Host. The American Journal Of Tropical Medicine And Hygiene 2021, 104: 175-183. PMID: 33258439, PMCID: PMC7790098, DOI: 10.4269/ajtmh.20-0776.
- Pal U, Kitsou C, Drecktrah D, Yaş ÖB, Fikrig E. Interactions Between Ticks and Lyme Disease Spirochetes. Current Issues In Molecular Biology 2021, 42: 113-144. PMID: 33289683, PMCID: PMC8045411, DOI: 10.21775/cimb.042.113.
- Černý J, Lynn G, DePonte K, Ledizet M, Narasimhan S, Fikrig E. Fractionation of tick saliva reveals proteins associated with the development of acquired resistance to Ixodes scapularis. Vaccine 2020, 38: 8121-8129. PMID: 33168347, DOI: 10.1016/j.vaccine.2020.10.087.
- Cao Y, Rosen C, Arora G, Gupta A, Booth CJ, Murfin KE, Cerny J, Marin Lopez A, Chuang YM, Tang X, Pal U, Ring A, Narasimhan S, Fikrig E. An Ixodes scapularis Protein Disulfide Isomerase Contributes to Borrelia burgdorferi Colonization of the Vector. Infection And Immunity 2020, 88 PMID: 32928964, PMCID: PMC7671890, DOI: 10.1128/IAI.00426-20.
- Lin T, Geng T, Harrison AG, Yang D, Vella AT, Fikrig E, Wang P. CXCL10 Signaling Contributes to the Pathogenesis of Arthritogenic Alphaviruses. Viruses 2020, 12 PMID: 33147869, PMCID: PMC7692144, DOI: 10.3390/v12111252.
- Kurokawa C, Narasimhan S, Vidyarthi A, Booth CJ, Mehta S, Meister L, Diktas H, Strank N, Lynn GE, DePonte K, Craft J, Fikrig E. Repeat tick exposure elicits distinct immune responses in guinea pigs and mice. Ticks And Tick-borne Diseases 2020, 11: 101529. PMID: 32993942, PMCID: PMC7530331, DOI: 10.1016/j.ttbdis.2020.101529.
- Gupta A, Arora G, Rosen CE, Kloos Z, Cao Y, Cerny J, Sajid A, Hoornstra D, Golovchenko M, Rudenko N, Munderloh U, Hovius JW, Booth CJ, Jacobs-Wagner C, Palm NW, Ring AM, Fikrig E. A human secretome library screen reveals a role for Peptidoglycan Recognition Protein 1 in Lyme borreliosis. PLoS Pathogens 2020, 16: e1009030. PMID: 33175909, PMCID: PMC7657531, DOI: 10.1371/journal.ppat.1009030.
- Yang L, Geng T, Yang G, Ma J, Wang L, Ketkar H, Yang D, Lin T, Hwang J, Zhu S, Wang Y, Dai J, You F, Cheng G, Vella AT, Flavell RA, Fikrig E, Wang P. Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice. Communications Biology 2020, 3: 556. PMID: 33033362, PMCID: PMC7545163, DOI: 10.1038/s42003-020-01285-6.
- Wang Y, Uraki R, Hwang J, Fikrig E. TRiC/CCT Complex, a Binding Partner of NS1 Protein, Supports the Replication of Zika Virus in Both Mammalians and Mosquitoes. Viruses 2020, 12 PMID: 32397176, PMCID: PMC7290343, DOI: 10.3390/v12050519.
- Narasimhan S, Kurokawa C, Diktas H, Strank NO, Černý J, Murfin K, Cao Y, Lynn G, Trentleman J, Wu MJ, DePonte K, Kantor F, Anguita J, Hovius J, Fikrig E. Ixodes scapularis saliva components that elicit responses associated with acquired tick-resistance. Ticks And Tick-borne Diseases 2020, 11: 101369. PMID: 31924502, PMCID: PMC7382422, DOI: 10.1016/j.ttbdis.2019.101369.
- Gomes-Solecki M, Arnaboldi PM, Backenson PB, Benach JL, Cooper CL, Dattwyler RJ, Diuk-Wasser M, Fikrig E, Hovius JW, Laegreid W, Lundberg U, Marconi RT, Marques AR, Molloy P, Narasimhan S, Pal U, Pedra JHF, Plotkin S, Rock DL, Rosa P, Telford SR, Tsao J, Yang XF, Schutzer SE. Protective Immunity and New Vaccines for Lyme Disease. Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America 2020, 70: 1768-1773. PMID: 31620776, PMCID: PMC7155782, DOI: 10.1093/cid/ciz872.
- Koetsveld J, Platonov AE, Kuleshov K, Wagemakers A, Hoornstra D, Ang W, Szekeres S, van Duijvendijk GLA, Fikrig E, Embers ME, Sprong H, Hovius JW. Borrelia miyamotoi infection leads to cross-reactive antibodies to the C6 peptide in mice and men. Clinical Microbiology And Infection : The Official Publication Of The European Society Of Clinical Microbiology And Infectious Diseases 2020, 26: 513.e1-513.e6. PMID: 31404672, DOI: 10.1016/j.cmi.2019.07.026.
- Wang Y, Marin-Lopez A, Jiang J, Ledizet M, Fikrig E. Vaccination with Aedes aegypti AgBR1 Delays Lethal Mosquito-Borne Zika Virus Infection in Mice. Vaccines 2020, 8 PMID: 32218189, PMCID: PMC7348886, DOI: 10.3390/vaccines8020145.
- Zhao Y, Amodio M, Vander Wyk B, Gerritsen B, Kumar MM, van Dijk D, Moon K, Wang X, Malawista A, Richards MM, Cahill ME, Desai A, Sivadasan J, Venkataswamy MM, Ravi V, Fikrig E, Kumar P, Kleinstein SH, Krishnaswamy S, Montgomery RR. Single cell immune profiling of dengue virus patients reveals intact immune responses to Zika virus with enrichment of innate immune signatures. PLoS Neglected Tropical Diseases 2020, 14: e0008112. PMID: 32150565, PMCID: PMC7082063, DOI: 10.1371/journal.pntd.0008112.
- Chuang YM, Freudzon M, Yang J, Dong Y, Dimopoulos G, Fikrig E. Anopheles gambiae Lacking AgTRIO Inefficiently Transmits Plasmodium berghei to Mice. Infection And Immunity 2019, 87 PMID: 31285253, PMCID: PMC6704594, DOI: 10.1128/IAI.00326-19.
- Hwang J, Wang Y, Fikrig E. Inhibition of Chikungunya Virus Replication in Primary Human Fibroblasts by Liver X Receptor Agonist. Antimicrobial Agents And Chemotherapy 2019, 63 PMID: 31307983, PMCID: PMC6709483, DOI: 10.1128/AAC.01220-19.
- Murfin KE, Kleinbard R, Aydin M, Salazar SA, Fikrig E. Borrelia burgdorferi chemotaxis toward tick protein Salp12 contributes to acquisition. Ticks And Tick-borne Diseases 2019, 10: 1124-1134. PMID: 31204044, PMCID: PMC7792743, DOI: 10.1016/j.ttbdis.2019.06.002.
- Hastings AK, Uraki R, Gaitsch H, Dhaliwal K, Stanley S, Sproch H, Williamson E, MacNeil T, Marin-Lopez A, Hwang J, Wang Y, Grover JR, Fikrig E. Aedes aegypti NeSt1 Protein Enhances Zika Virus Pathogenesis by Activating Neutrophils. Journal Of Virology 2019, 93 PMID: 30971475, PMCID: PMC6580965, DOI: 10.1128/JVI.00395-19.
- Uraki R, Hastings AK, Marin-Lopez A, Sumida T, Takahashi T, Grover JR, Iwasaki A, Hafler DA, Montgomery RR, Fikrig E. Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice. Nature Microbiology 2019, 4: 948-955. PMID: 30858571, PMCID: PMC6533137, DOI: 10.1038/s41564-019-0385-x.
- Wang D, Zhang Z, Cui S, Zhao Y, Craft S, Fikrig E, You F. ELF4 facilitates innate host defenses against Plasmodium by activating transcription of Pf4 and Ppbp. The Journal Of Biological Chemistry 2019, 294: 7787-7796. PMID: 30898878, PMCID: PMC6514618, DOI: 10.1074/jbc.RA118.006321.
- Hastings AK, Hastings K, Uraki R, Hwang J, Gaitsch H, Dhaliwal K, Williamson E, Fikrig E. Loss of the TAM Receptor Axl Ameliorates Severe Zika Virus Pathogenesis and Reduces Apoptosis in Microglia. IScience 2019, 13: 339-350. PMID: 30884311, PMCID: PMC6424058, DOI: 10.1016/j.isci.2019.03.003.
- Cao L, Yang G, Gao S, Jing C, Montgomery RR, Yin Y, Wang P, Fikrig E, You F. HIPK2 is necessary for type I interferon-mediated antiviral immunity. Science Signaling 2019, 12 PMID: 30890658, PMCID: PMC6893850, DOI: 10.1126/scisignal.aau4604.
- Schutzer SE, Body BA, Boyle J, Branson BM, Dattwyler RJ, Fikrig E, Gerald NJ, Gomes-Solecki M, Kintrup M, Ledizet M, Levin AE, Lewinski M, Liotta LA, Marques A, Mead PS, Mongodin EF, Pillai S, Rao P, Robinson WH, Roth KM, Schriefer ME, Slezak T, Snyder JL, Steere AC, Witkowski J, Wong SJ, Branda JA. Direct Diagnostic Tests for Lyme Disease. Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America 2019, 68: 1052-1057. PMID: 30307486, PMCID: PMC6399434, DOI: 10.1093/cid/ciy614.
- Coumou J, Wagemakers A, Narasimhan S, Schuijt TJ, Ersoz JI, Oei A, de Boer OJ, Roelofs JJTH, Fikrig E, Hovius JW. The role of Mannose Binding Lectin in the immune response against Borrelia burgdorferi sensu lato. Scientific Reports 2019, 9: 1431. PMID: 30723261, PMCID: PMC6363739, DOI: 10.1038/s41598-018-37922-8.
- Narasimhan S, Booth CJ, DePonte K, Wu MJ, Liang X, Mohanty S, Kantor F, Fikrig E. Host-specific expression of Ixodes scapularis salivary genes. Ticks And Tick-borne Diseases 2019, 10: 386-397. PMID: 30545615, DOI: 10.1016/j.ttbdis.2018.12.001.
- Marín-Lopez A, Calvo-Pinilla E, Moreno S, Utrilla-Trigo S, Nogales A, Brun A, Fikrig E, Ortego J. Modeling Arboviral Infection in Mice Lacking the Interferon Alpha/Beta Receptor. Viruses 2019, 11 PMID: 30625992, PMCID: PMC6356211, DOI: 10.3390/v11010035.
- Hwang J, Jiang A, Fikrig E. A potent prolyl tRNA synthetase inhibitor antagonizes Chikungunya and Dengue viruses. Antiviral Research 2019, 161: 163-168. PMID: 30521835, PMCID: PMC6345585, DOI: 10.1016/j.antiviral.2018.11.017.
- Uraki R, Hastings AK, Brackney DE, Armstrong PM, Fikrig E. AgBR1 antibodies delay lethal Aedes aegypti-borne West Nile virus infection in mice. NPJ Vaccines 2019, 4: 23. PMID: 31312526, PMCID: PMC6614468, DOI: 10.1038/s41541-019-0120-x.
- Hwang J, Jiang A, Fikrig E. Rev-erb Agonist Inhibits Chikungunya and O'nyong'nyong Virus Replication. Open Forum Infectious Diseases 2018, 5: ofy315. PMID: 30568983, PMCID: PMC6293476, DOI: 10.1093/ofid/ofy315.
- Shaw DK, Tate AT, Schneider DS, Levashina EA, Kagan JC, Pal U, Fikrig E, Pedra JHF. Vector Immunity and Evolutionary Ecology: The Harmonious Dissonance. Trends In Immunology 2018, 39: 862-873. PMID: 30301592, PMCID: PMC6218297, DOI: 10.1016/j.it.2018.09.003.
- Schleicher TR, Yang J, Freudzon M, Rembisz A, Craft S, Hamilton M, Graham M, Mlambo G, Tripathi AK, Li Y, Cresswell P, Sinnis P, Dimopoulos G, Fikrig E. A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission. Nature Communications 2018, 9: 2908. PMID: 30046053, PMCID: PMC6060088, DOI: 10.1038/s41467-018-05374-3.
- Baeza Garcia A, Siu E, Sun T, Exler V, Brito L, Hekele A, Otten G, Augustijn K, Janse CJ, Ulmer JB, Bernhagen J, Fikrig E, Geall A, Bucala R. Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection. Nature Communications 2018, 9: 2714. PMID: 30006528, PMCID: PMC6045615, DOI: 10.1038/s41467-018-05041-7.
- Heipertz EL, Harper J, Lopez CA, Fikrig E, Hughes ME, Walker WE. Circadian Rhythms Influence the Severity of Sepsis in Mice via a TLR2-Dependent, Leukocyte-Intrinsic Mechanism. Journal Of Immunology (Baltimore, Md. : 1950) 2018, 201: 193-201. PMID: 29760192, PMCID: PMC9351006, DOI: 10.4049/jimmunol.1701677.
- Yang L, Wang L, Ketkar H, Ma J, Yang G, Cui S, Geng T, Mordue DG, Fujimoto T, Cheng G, You F, Lin R, Fikrig E, Wang P. UBXN3B positively regulates STING-mediated antiviral immune responses. Nature Communications 2018, 9: 2329. PMID: 29899553, PMCID: PMC5998066, DOI: 10.1038/s41467-018-04759-8.
- Moss CE, Robson A, Fikrig E, Narasimhan S. Visualization of Microbiota in Tick Guts by Whole-mount In Situ Hybridization. Journal Of Visualized Experiments : JoVE 2018 PMID: 29912204, PMCID: PMC6101453, DOI: 10.3791/57758.
- Beloor J, Maes N, Ullah I, Uchil P, Jackson A, Fikrig E, Lee SK, Kumar P. Small Interfering RNA-Mediated Control of Virus Replication in the CNS Is Therapeutic and Enables Natural Immunity to West Nile Virus. Cell Host & Microbe 2018, 23: 549-556.e3. PMID: 29606496, PMCID: PMC6074029, DOI: 10.1016/j.chom.2018.03.001.
- Dragovic SM, Agunbiade TA, Freudzon M, Yang J, Hastings AK, Schleicher TR, Zhou X, Craft S, Chuang YM, Gonzalez F, Li Y, Hrebikova G, Tripathi A, Mlambo G, Almeras L, Ploss A, Dimopoulos G, Fikrig E. Immunization with AgTRIO, a Protein in Anopheles Saliva, Contributes to Protection against Plasmodium Infection in Mice. Cell Host & Microbe 2018, 23: 523-535.e5. PMID: 29649443, PMCID: PMC5998332, DOI: 10.1016/j.chom.2018.03.008.
- Branda JA, Body BA, Boyle J, Branson BM, Dattwyler RJ, Fikrig E, Gerald NJ, Gomes-Solecki M, Kintrup M, Ledizet M, Levin AE, Lewinski M, Liotta LA, Marques A, Mead PS, Mongodin EF, Pillai S, Rao P, Robinson WH, Roth KM, Schriefer ME, Slezak T, Snyder J, Steere AC, Witkowski J, Wong SJ, Schutzer SE. Advances in Serodiagnostic Testing for Lyme Disease Are at Hand. Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America 2018, 66: 1133-1139. PMID: 29228208, PMCID: PMC6019075, DOI: 10.1093/cid/cix943.
- Uraki R, Hastings AK, Gloria-Soria A, Powell JR, Fikrig E. Altered vector competence in an experimental mosquito-mouse transmission model of Zika infection. PLoS Neglected Tropical Diseases 2018, 12: e0006350. PMID: 29505571, PMCID: PMC5854422, DOI: 10.1371/journal.pntd.0006350.
- Silver AC, Buckley SM, Hughes ME, Hastings AK, Nitabach MN, Fikrig E. Daily oscillations in expression and responsiveness of Toll-like receptors in splenic immune cells. Heliyon 2018, 4: e00579. PMID: 29862343, PMCID: PMC5968137, DOI: 10.1016/j.heliyon.2018.e00579.
- Yockey LJ, Jurado KA, Arora N, Millet A, Rakib T, Milano KM, Hastings AK, Fikrig E, Kong Y, Horvath TL, Weatherbee S, Kliman HJ, Coyne CB, Iwasaki A. Type I interferons instigate fetal demise after Zika virus infection. Science Immunology 2018, 3 PMID: 29305462, PMCID: PMC6049088, DOI: 10.1126/sciimmunol.aao1680.
- Krause PJ, Carroll M, Fedorova N, Brancato J, Dumouchel C, Akosa F, Narasimhan S, Fikrig E, Lane RS. Human Borrelia miyamotoi infection in California: Serodiagnosis is complicated by multiple endemic Borrelia species. PloS One 2018, 13: e0191725. PMID: 29420552, PMCID: PMC5805228, DOI: 10.1371/journal.pone.0191725.
- Smith AA, Yang X, Fikrig E, Pal U. Artificial Infection of Ticks with Borrelia burgdorferi Using a Microinjection Method and Their Detection In Vivo Using Quantitative PCR Targeting flaB RNA. Methods In Molecular Biology (Clifton, N.J.) 2018, 1690: 105-114. PMID: 29032540, DOI: 10.1007/978-1-4939-7383-5_9.
- Du H, Cui S, Li Y, Yang G, Wang P, Fikrig E, You F. MiR-221 negatively regulates innate anti-viral response. PloS One 2018, 13: e0200385. PMID: 30089112, PMCID: PMC6082502, DOI: 10.1371/journal.pone.0200385.
- Narasimhan S, Schuijt TJ, Abraham NM, Rajeevan N, Coumou J, Graham M, Robson A, Wu MJ, Daffre S, Hovius JW, Fikrig E. Modulation of the tick gut milieu by a secreted tick protein favors Borrelia burgdorferi colonization. Nature Communications 2017, 8: 184. PMID: 28775250, PMCID: PMC5543126, DOI: 10.1038/s41467-017-00208-0.
- Abraham NM, Liu L, Jutras BL, Murfin K, Acar A, Yarovinsky TO, Sutton E, Heisig M, Jacobs-Wagner C, Fikrig E. A Tick Antivirulence Protein Potentiates Antibiotics against Staphylococcus aureus. Antimicrobial Agents And Chemotherapy 2017, 61 PMID: 28438938, PMCID: PMC5487661, DOI: 10.1128/AAC.00113-17.
- Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA. Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature 2017, 546: 667-670. PMID: 28636595, PMCID: PMC5787375, DOI: 10.1038/nature22967.
- Wang L, Yang L, Fikrig E, Wang P. An essential role of PI3K in the control of West Nile virus infection. Scientific Reports 2017, 7: 3724. PMID: 28623344, PMCID: PMC5473900, DOI: 10.1038/s41598-017-03912-5.
- Uraki R, Jurado KA, Hwang J, Szigeti-Buck K, Horvath TL, Iwasaki A, Fikrig E. Fetal Growth Restriction Caused by Sexual Transmission of Zika Virus in Mice. The Journal Of Infectious Diseases 2017, 215: 1720-1724. PMID: 28472297, PMCID: PMC5853330, DOI: 10.1093/infdis/jix204.
- Hastings AK, Fikrig E. Zika Virus and Sexual Transmission: A New Route of Transmission for Mosquito-borne Flaviviruses . The Yale Journal Of Biology And Medicine 2017, 90: 325-330. PMID: 28656018, PMCID: PMC5482308.
- Hastings AK, Yockey LJ, Jagger BW, Hwang J, Uraki R, Gaitsch HF, Parnell LA, Cao B, Mysorekar IU, Rothlin CV, Fikrig E, Diamond MS, Iwasaki A. TAM Receptors Are Not Required for Zika Virus Infection in Mice. Cell Reports 2017, 19: 558-568. PMID: 28423319, PMCID: PMC5485843, DOI: 10.1016/j.celrep.2017.03.058.
- Shaw DK, Wang X, Brown LJ, Chávez AS, Reif KE, Smith AA, Scott AJ, McClure EE, Boradia VM, Hammond HL, Sundberg EJ, Snyder GA, Liu L, DePonte K, Villar M, Ueti MW, de la Fuente J, Ernst RK, Pal U, Fikrig E, Pedra JH. Infection-derived lipids elicit an immune deficiency circuit in arthropods. Nature Communications 2017, 8: 14401. PMID: 28195158, PMCID: PMC5316886, DOI: 10.1038/ncomms14401.
- Simoni MK, Jurado KA, Abrahams VM, Fikrig E, Guller S. Zika virus infection of Hofbauer cells. American Journal Of Reproductive Immunology (New York, N.Y. : 1989) 2017, 77 PMID: 27966815, PMCID: PMC5299062, DOI: 10.1111/aji.12613.
- Hu Y, O'Boyle K, Auer J, Raju S, You F, Wang P, Fikrig E, Sutton RE. Multiple UBXN family members inhibit retrovirus and lentivirus production and canonical NFκΒ signaling by stabilizing IκBα. PLoS Pathogens 2017, 13: e1006187. PMID: 28152074, PMCID: PMC5308826, DOI: 10.1371/journal.ppat.1006187.
- Uraki R, Hwang J, Jurado KA, Householder S, Yockey LJ, Hastings AK, Homer RJ, Iwasaki A, Fikrig E. Zika virus causes testicular atrophy. Science Advances 2017, 3: e1602899. PMID: 28261663, PMCID: PMC5321463, DOI: 10.1126/sciadv.1602899.
- Abraham NM, Liu L, Jutras BL, Yadav AK, Narasimhan S, Gopalakrishnan V, Ansari JM, Jefferson KK, Cava F, Jacobs-Wagner C, Fikrig E. Pathogen-mediated manipulation of arthropod microbiota to promote infection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: E781-E790. PMID: 28096373, PMCID: PMC5293115, DOI: 10.1073/pnas.1613422114.
- Murfin KE, Fikrig E. Tick Bioactive Molecules as Novel Therapeutics: Beyond Vaccine Targets. Frontiers In Cellular And Infection Microbiology 2017, 7: 222. PMID: 28634573, PMCID: PMC5459892, DOI: 10.3389/fcimb.2017.00222.
- Acharya D, Wang P, Paul AM, Dai J, Gate D, Lowery JE, Stokic DS, Leis AA, Flavell RA, Town T, Fikrig E, Bai F. Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance. Journal Of Virology 2017, 91 PMID: 27795421, PMCID: PMC5165211, DOI: 10.1128/JVI.01529-16.
- Ansari JM, Abraham NM, Massaro J, Murphy K, Smith-Carpenter J, Fikrig E. Anti-Biofilm Activity of a Self-Aggregating Peptide against Streptococcus mutans. Frontiers In Microbiology 2017, 8: 488. PMID: 28392782, PMCID: PMC5364132, DOI: 10.3389/fmicb.2017.00488.
- Paul AM, Acharya D, Le L, Wang P, Stokic DS, Leis AA, Alexopoulou L, Town T, Flavell RA, Fikrig E, Bai F. TLR8 Couples SOCS-1 and Restrains TLR7-Mediated Antiviral Immunity, Exacerbating West Nile Virus Infection in Mice. Journal Of Immunology (Baltimore, Md. : 1950) 2016, 197: 4425-4435. PMID: 27798161, PMCID: PMC5123688, DOI: 10.4049/jimmunol.1600902.
- Troupin A, Londono-Renteria B, Conway MJ, Cloherty E, Jameson S, Higgs S, Vanlandingham DL, Fikrig E, Colpitts TM. A novel mosquito ubiquitin targets viral envelope protein for degradation and reduces virion production during dengue virus infection. Biochimica Et Biophysica Acta 2016, 1860: 1898-909. PMID: 27241849, PMCID: PMC4949077, DOI: 10.1016/j.bbagen.2016.05.033.
- Conway MJ, Londono-Renteria B, Troupin A, Watson AM, Klimstra WB, Fikrig E, Colpitts TM. Aedes aegypti D7 Saliva Protein Inhibits Dengue Virus Infection. PLoS Neglected Tropical Diseases 2016, 10: e0004941. PMID: 27632170, PMCID: PMC5025043, DOI: 10.1371/journal.pntd.0004941.
- Jurado KA, Simoni MK, Tang Z, Uraki R, Hwang J, Householder S, Wu M, Lindenbach BD, Abrahams VM, Guller S, Fikrig E. Zika virus productively infects primary human placenta-specific macrophages. JCI Insight 2016, 1 PMID: 27595140, PMCID: PMC5007065, DOI: 10.1172/jci.insight.88461.
- Wagemakers A, Koetsveld J, Narasimhan S, Wickel M, Deponte K, Bleijlevens B, Jahfari S, Sprong H, Karan LS, Sarksyan DS, van der Poll T, Bockenstedt LK, Bins AD, Platonov AE, Fikrig E, Hovius JW. Variable Major Proteins as Targets for Specific Antibodies against Borrelia miyamotoi. Journal Of Immunology (Baltimore, Md. : 1950) 2016, 196: 4185-95. PMID: 27076681, PMCID: PMC5008243, DOI: 10.4049/jimmunol.1600014.
- Hwang J, Jurado KA, Fikrig E. Genetics of War and Truce between Mosquitos and Emerging Viruses. Cell Host & Microbe 2016, 19: 583-7. PMID: 27173926, PMCID: PMC7063512, DOI: 10.1016/j.chom.2016.04.009.
- Coumou J, Narasimhan S, Trentelman JJ, Wagemakers A, Koetsveld J, Ersoz JI, Oei A, Fikrig E, Hovius JW. Ixodes scapularis dystroglycan-like protein promotes Borrelia burgdorferi migration from the gut. Journal Of Molecular Medicine (Berlin, Germany) 2016, 94: 361-70. PMID: 26594018, PMCID: PMC4803822, DOI: 10.1007/s00109-015-1365-0.
- Wang P, Zhu S, Yang L, Cui S, Pan W, Jackson R, Zheng Y, Rongvaux A, Sun Q, Yang G, Gao S, Lin R, You F, Flavell R, Fikrig E. Nlrp6 regulates intestinal antiviral innate immunity. Science (New York, N.Y.) 2015, 350: 826-30. PMID: 26494172, PMCID: PMC4927078, DOI: 10.1126/science.aab3145.
- Londono-Renteria B, Troupin A, Conway MJ, Vesely D, Ledizet M, Roundy CM, Cloherty E, Jameson S, Vanlandingham D, Higgs S, Fikrig E, Colpitts TM. Dengue Virus Infection of Aedes aegypti Requires a Putative Cysteine Rich Venom Protein. PLoS Pathogens 2015, 11: e1005202. PMID: 26491875, PMCID: PMC4619585, DOI: 10.1371/journal.ppat.1005202.
- Narasimhan S, Fikrig E. Tick microbiome: the force within. Trends In Parasitology 2015, 31: 315-23. PMID: 25936226, PMCID: PMC4492851, DOI: 10.1016/j.pt.2015.03.010.
- Walker WE, Kurscheid S, Joshi S, Lopez CA, Goh G, Choi M, Barakat L, Francis J, Fisher A, Kozal M, Zapata H, Shaw A, Lifton R, Sutton RE, Fikrig E. Increased Levels of Macrophage Inflammatory Proteins Result in Resistance to R5-Tropic HIV-1 in a Subset of Elite Controllers. Journal Of Virology 2015, 89: 5502-14. PMID: 25740989, PMCID: PMC4442529, DOI: 10.1128/JVI.00118-15.
- Qian F, Goel G, Meng H, Wang X, You F, Devine L, Raddassi K, Garcia MN, Murray KO, Bolen CR, Gaujoux R, Shen-Orr SS, Hafler D, Fikrig E, Xavier R, Kleinstein SH, Montgomery RR. Systems immunology reveals markers of susceptibility to West Nile virus infection. Clinical And Vaccine Immunology : CVI 2015, 22: 6-16. PMID: 25355795, PMCID: PMC4278927, DOI: 10.1128/CVI.00508-14.
- Heisig M, Mattessich S, Rembisz A, Acar A, Shapiro M, Booth CJ, Neelakanta G, Fikrig E. Frostbite protection in mice expressing an antifreeze glycoprotein. PloS One 2015, 10: e0116562. PMID: 25714402, PMCID: PMC4340617, DOI: 10.1371/journal.pone.0116562.
- Fikrig E, Turchick A, Czochor J. Vaccine development: how scientific collaboration and communication help prevent the spread of disease: an interview with Erol Fikrig, MD. The Yale Journal Of Biology And Medicine 2014, 87: 519-25. PMID: 25506284, PMCID: PMC4257037.
- Conway MJ, Colpitts TM, Fikrig E. Role of the Vector in Arbovirus Transmission. Annual Review Of Virology 2014, 1: 71-88. PMID: 26958715, PMCID: PMC7809425, DOI: 10.1146/annurev-virology-031413-085513.
- Heisig M, Abraham NM, Liu L, Neelakanta G, Mattessich S, Sultana H, Shang Z, Ansari JM, Killiam C, Walker W, Cooley L, Flavell RA, Agaisse H, Fikrig E. Antivirulence properties of an antifreeze protein. Cell Reports 2014, 9: 417-24. PMID: 25373896, PMCID: PMC4223805, DOI: 10.1016/j.celrep.2014.09.034.
- Li MW, Wang J, Zhao YO, Fikrig E. Innexin AGAP001476 is critical for mediating anti-Plasmodium responses in Anopheles mosquitoes. The Journal Of Biological Chemistry 2014, 289: 24885-97. PMID: 25035430, PMCID: PMC4155657, DOI: 10.1074/jbc.M114.554519.
- Narasimhan S, Coumou J, Schuijt TJ, Boder E, Hovius JW, Fikrig E. A tick gut protein with fibronectin III domains aids Borrelia burgdorferi congregation to the gut during transmission. PLoS Pathogens 2014, 10: e1004278. PMID: 25102051, PMCID: PMC4125277, DOI: 10.1371/journal.ppat.1004278.
- Seidman D, Ojogun N, Walker NJ, Mastronunzio J, Kahlon A, Hebert KS, Karandashova S, Miller DP, Tegels BK, Marconi RT, Fikrig E, Borjesson DL, Carlyon JA. Anaplasma phagocytophilum surface protein AipA mediates invasion of mammalian host cells. Cellular Microbiology 2014, 16: 1133-45. PMID: 24612118, PMCID: PMC4115035, DOI: 10.1111/cmi.12286.
- Krause PJ, Narasimhan S, Wormser GP, Barbour AG, Platonov AE, Brancato J, Lepore T, Dardick K, Mamula M, Rollend L, Steeves TK, Diuk-Wasser M, Usmani-Brown S, Williamson P, Sarksyan DS, Fikrig E, Fish D. Borrelia miyamotoi sensu lato seroreactivity and seroprevalence in the northeastern United States. Emerging Infectious Diseases 2014, 20: 1183-90. PMID: 24960072, PMCID: PMC4073859, DOI: 10.3201/eid2007.131587.
- Qian F, Thakar J, Yuan X, Nolan M, Murray KO, Lee WT, Wong SJ, Meng H, Fikrig E, Kleinstein SH, Montgomery RR. Immune markers associated with host susceptibility to infection with West Nile virus. Viral Immunology 2014, 27: 39-47. PMID: 24605787, PMCID: PMC3949440, DOI: 10.1089/vim.2013.0074.
- Juthani-Mehta M, Guo X, Shaw AC, Towle V, Ning Y, Wang X, Allore HG, Fikrig E, Montgomery RR. Innate Immune Responses in the Neutrophils of Community Dwelling and Nursing Home Elders. Journal Of Aging Science 2014, 2 PMID: 25750929, PMCID: PMC4348001, DOI: 10.4172/2329-8847.1000115.
- Narasimhan S, Rajeevan N, Liu L, Zhao YO, Heisig J, Pan J, Eppler-Epstein R, Deponte K, Fish D, Fikrig E. Gut microbiota of the tick vector Ixodes scapularis modulate colonization of the Lyme disease spirochete. Cell Host & Microbe 2014, 15: 58-71. PMID: 24439898, PMCID: PMC3905459, DOI: 10.1016/j.chom.2013.12.001.
- Conway MJ, Watson AM, Colpitts TM, Dragovic SM, Li Z, Wang P, Feitosa F, Shepherd DT, Ryman KD, Klimstra WB, Anderson JF, Fikrig E. Mosquito saliva serine protease enhances dissemination of dengue virus into the mammalian host. Journal Of Virology 2014, 88: 164-75. PMID: 24131723, PMCID: PMC3911723, DOI: 10.1128/JVI.02235-13.
- You F, Wang P, Yang L, Yang G, Zhao YO, Qian F, Walker W, Sutton R, Montgomery R, Lin R, Iwasaki A, Fikrig E. ELF4 is critical for induction of type I interferon and the host antiviral response. Nature Immunology 2013, 14: 1237-46. PMID: 24185615, PMCID: PMC3939855, DOI: 10.1038/ni.2756.
- Bobenchik AM, Witola WH, Augagneur Y, Nic Lochlainn L, Garg A, Pachikara N, Choi JY, Zhao YO, Usmani-Brown S, Lee A, Adjalley SH, Samanta S, Fidock DA, Voelker DR, Fikrig E, Ben Mamoun C. Plasmodium falciparum phosphoethanolamine methyltransferase is essential for malaria transmission. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 18262-7. PMID: 24145416, PMCID: PMC3831454, DOI: 10.1073/pnas.1313965110.
- Wang J, Zhang Y, Zhao YO, Li MW, Zhang L, Dragovic S, Abraham NM, Fikrig E. Anopheles gambiae circumsporozoite protein-binding protein facilitates plasmodium infection of mosquito salivary glands. The Journal Of Infectious Diseases 2013, 208: 1161-9. PMID: 23801601, PMCID: PMC3762383, DOI: 10.1093/infdis/jit284.
- Yang X, Hegde S, Shroder DY, Smith AA, Promnares K, Neelakanta G, Anderson JF, Fikrig E, Pal U. The lipoprotein La7 contributes to Borrelia burgdorferi persistence in ticks and their transmission to naïve hosts. Microbes And Infection / Institut Pasteur 2013, 15: 729-37. PMID: 23774694, PMCID: PMC3769513, DOI: 10.1016/j.micinf.2013.06.001.
- Hovius JW, de Wever B, Sohne M, Brouwer MC, Coumou J, Wagemakers A, Oei A, Knol H, Narasimhan S, Hodiamont CJ, Jahfari S, Pals ST, Horlings HM, Fikrig E, Sprong H, van Oers MH. A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe. Lancet 2013, 382: 658. PMID: 23953389, PMCID: PMC3987849, DOI: 10.1016/S0140-6736(13)61644-X.
- Schuijt TJ, Bakhtiari K, Daffre S, Deponte K, Wielders SJ, Marquart JA, Hovius JW, van der Poll T, Fikrig E, Bunce MW, Camire RM, Nicolaes GA, Meijers JC, van 't Veer C. Factor Xa activation of factor V is of paramount importance in initiating the coagulation system: lessons from a tick salivary protein. Circulation 2013, 128: 254-66. PMID: 23817575, PMCID: PMC3826089, DOI: 10.1161/CIRCULATIONAHA.113.003191.
- Qian F, Chung L, Zheng W, Bruno V, Alexander RP, Wang Z, Wang X, Kurscheid S, Zhao H, Fikrig E, Gerstein M, Snyder M, Montgomery RR. Identification of genes critical for resistance to infection by West Nile virus using RNA-Seq analysis. Viruses 2013, 5: 1664-81. PMID: 23881275, PMCID: PMC3738954, DOI: 10.3390/v5071664.
- Wang P, Yang L, Cheng G, Yang G, Xu Z, You F, Sun Q, Lin R, Fikrig E, Sutton RE. UBXN1 interferes with Rig-I-like receptor-mediated antiviral immune response by targeting MAVS. Cell Reports 2013, 3: 1057-70. PMID: 23545497, PMCID: PMC3707122, DOI: 10.1016/j.celrep.2013.02.027.
- Magnarelli LA, Williams SC, Norris SJ, Fikrig E. Serum antibodies to Borrelia burgdorferi, Anaplasma phagocytophilum, and Babesia microti in recaptured white-footed mice. Journal Of Wildlife Diseases 2013, 49: 294-302. PMID: 23568904, PMCID: PMC3712766, DOI: 10.7589/2012-06-172.
- Qian F, Bolen CR, Jing C, Wang X, Zheng W, Zhao H, Fikrig E, Bruce RD, Kleinstein SH, Montgomery RR. Impaired toll-like receptor 3-mediated immune responses from macrophages of patients chronically infected with hepatitis C virus. Clinical And Vaccine Immunology : CVI 2013, 20: 146-55. PMID: 23220997, PMCID: PMC3571267, DOI: 10.1128/CVI.00530-12.
- Ullmann AJ, Dolan MC, Sackal CA, Fikrig E, Piesman J, Zeidner NS. Immunization with adenoviral-vectored tick salivary gland proteins (SALPs) in a murine model of Lyme borreliosis. Ticks And Tick-borne Diseases 2013, 4: 160-3. PMID: 23141105, PMCID: PMC4306421, DOI: 10.1016/j.ttbdis.2012.08.006.
- Krause PJ, Narasimhan S, Wormser GP, Rollend L, Fikrig E, Lepore T, Barbour A, Fish D. Human Borrelia miyamotoi infection in the United States. The New England Journal Of Medicine 2013, 368: 291-3. PMID: 23323920, PMCID: PMC3934646, DOI: 10.1056/NEJMc1215469.
- Silver AC, Dunne DW, Zeiss CJ, Bockenstedt LK, Radolf JD, Salazar JC, Fikrig E. MyD88 deficiency markedly worsens tissue inflammation and bacterial clearance in mice infected with Treponema pallidum, the agent of syphilis. PloS One 2013, 8: e71388. PMID: 23940747, PMCID: PMC3734110, DOI: 10.1371/journal.pone.0071388.
- Narasimhan S, Perez O, Mootien S, DePonte K, Koski RA, Fikrig E, Ledizet M. Characterization of Ixophilin, a thrombin inhibitor from the gut of Ixodes scapularis. PloS One 2013, 8: e68012. PMID: 23874485, PMCID: PMC3706618, DOI: 10.1371/journal.pone.0068012.
- Kahlon A, Ojogun N, Ragland SA, Seidman D, Troese MJ, Ottens AK, Mastronunzio JE, Truchan HK, Walker NJ, Borjesson DL, Fikrig E, Carlyon JA. Anaplasma phagocytophilum Asp14 is an invasin that interacts with mammalian host cells via its C terminus to facilitate infection. Infection And Immunity 2013, 81: 65-79. PMID: 23071137, PMCID: PMC3536139, DOI: 10.1128/IAI.00932-12.
- Arjona A, Silver AC, Walker WE, Fikrig E. Immunity's fourth dimension: approaching the circadian-immune connection. Trends In Immunology 2012, 33: 607-12. PMID: 23000010, PMCID: PMC3712756, DOI: 10.1016/j.it.2012.08.007.
- Sukumaran B, Ogura Y, Pedra JH, Kobayashi KS, Flavell RA, Fikrig E. Receptor interacting protein-2 contributes to host defense against Anaplasma phagocytophilum infection. FEMS Immunology And Medical Microbiology 2012, 66: 211-9. PMID: 22747758, PMCID: PMC3530031, DOI: 10.1111/j.1574-695X.2012.01001.x.
- Ojogun N, Kahlon A, Ragland SA, Troese MJ, Mastronunzio JE, Walker NJ, Viebrock L, Thomas RJ, Borjesson DL, Fikrig E, Carlyon JA. Anaplasma phagocytophilum outer membrane protein A interacts with sialylated glycoproteins to promote infection of mammalian host cells. Infection And Immunity 2012, 80: 3748-60. PMID: 22907813, PMCID: PMC3486060, DOI: 10.1128/IAI.00654-12.
- Colpitts TM, Conway MJ, Montgomery RR, Fikrig E. West Nile Virus: biology, transmission, and human infection. Clinical Microbiology Reviews 2012, 25: 635-48. PMID: 23034323, PMCID: PMC3485754, DOI: 10.1128/CMR.00045-12.
- Liu L, Dai J, Zhao YO, Narasimhan S, Yang Y, Zhang L, Fikrig E. Ixodes scapularis JAK-STAT pathway regulates tick antimicrobial peptides, thereby controlling the agent of human granulocytic anaplasmosis. The Journal Of Infectious Diseases 2012, 206: 1233-41. PMID: 22859824, PMCID: PMC3448968, DOI: 10.1093/infdis/jis484.
- Sultana H, Neelakanta G, Foellmer HG, Montgomery RR, Anderson JF, Koski RA, Medzhitov RM, Fikrig E. Semaphorin 7A contributes to West Nile virus pathogenesis through TGF-β1/Smad6 signaling. Journal Of Immunology (Baltimore, Md. : 1950) 2012, 189: 3150-8. PMID: 22896629, PMCID: PMC3496209, DOI: 10.4049/jimmunol.1201140.
- Mastronunzio JE, Kurscheid S, Fikrig E. Postgenomic analyses reveal development of infectious Anaplasma phagocytophilum during transmission from ticks to mice. Journal Of Bacteriology 2012, 194: 2238-47. PMID: 22389475, PMCID: PMC3347074, DOI: 10.1128/JB.06791-11.
- Ouyang Z, Narasimhan S, Neelakanta G, Kumar M, Pal U, Fikrig E, Norgard MV. Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi. BMC Microbiology 2012, 12: 44. PMID: 22443136, PMCID: PMC3320556, DOI: 10.1186/1471-2180-12-44.
- Silver AC, Arjona A, Hughes ME, Nitabach MN, Fikrig E. Circadian expression of clock genes in mouse macrophages, dendritic cells, and B cells. Brain, Behavior, And Immunity 2012, 26: 407-13. PMID: 22019350, PMCID: PMC3336152, DOI: 10.1016/j.bbi.2011.10.001.
- Silver AC, Arjona A, Walker WE, Fikrig E. The circadian clock controls toll-like receptor 9-mediated innate and adaptive immunity. Immunity 2012, 36: 251-61. PMID: 22342842, PMCID: PMC3315694, DOI: 10.1016/j.immuni.2011.12.017.
- Qian F, Wang X, Zhang L, Chen S, Piecychna M, Allore H, Bockenstedt L, Malawista S, Bucala R, Shaw AC, Fikrig E, Montgomery RR. Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly. Aging Cell 2012, 11: 104-10. PMID: 22023165, PMCID: PMC3257374, DOI: 10.1111/j.1474-9726.2011.00759.x.
- Wang P, Bai F, Zenewicz LA, Dai J, Gate D, Cheng G, Yang L, Qian F, Yuan X, Montgomery RR, Flavell RA, Town T, Fikrig E. IL-22 signaling contributes to West Nile encephalitis pathogenesis. PloS One 2012, 7: e44153. PMID: 22952908, PMCID: PMC3429482, DOI: 10.1371/journal.pone.0044153.
- Neelakanta G, Hudson AM, Sultana H, Cooley L, Fikrig E. Expression of Ixodes scapularis antifreeze glycoprotein enhances cold tolerance in Drosophila melanogaster. PloS One 2012, 7: e33447. PMID: 22428051, PMCID: PMC3302814, DOI: 10.1371/journal.pone.0033447.
- Zhao YO, Kurscheid S, Zhang Y, Liu L, Zhang L, Loeliger K, Fikrig E. Enhanced survival of Plasmodium-infected mosquitoes during starvation. PloS One 2012, 7: e40556. PMID: 22808193, PMCID: PMC3393683, DOI: 10.1371/journal.pone.0040556.
- da Silva Voorham JM, Rodenhuis-Zybert IA, Ayala Nuñez NV, Colpitts TM, van der Ende-Metselaar H, Fikrig E, Diamond MS, Wilschut J, Smit JM. Antibodies against the envelope glycoprotein promote infectivity of immature dengue virus serotype 2. PloS One 2012, 7: e29957. PMID: 22431958, PMCID: PMC3303773, DOI: 10.1371/journal.pone.0029957.
- Magnarelli LA, Norris SJ, Fikrig E. Serum antibodies to whole-cell and recombinant antigens of Borrelia burgdorferi in cottontail rabbits. Journal Of Wildlife Diseases 2012, 48: 12-20. PMID: 22247369, PMCID: PMC3261588, DOI: 10.7589/0090-3558-48.1.12.
- Anderson JF, Main AJ, Cheng G, Ferrandino FJ, Fikrig E. Horizontal and vertical transmission of West Nile virus genotype NY99 by Culex salinarius and genotypes NY99 and WN02 by Culex tarsalis. The American Journal Of Tropical Medicine And Hygiene 2012, 86: 134-9. PMID: 22232464, PMCID: PMC3247122, DOI: 10.4269/ajtmh.2012.11-0473.
- Biswas S, Chang H, Sarkis PT, Fikrig E, Zhu Q, Marasco WA. Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV-1 envelope proteins are largely mediated via human CD5+ B cells. Immunology 2011, 134: 419-33. PMID: 22044090, PMCID: PMC3230796, DOI: 10.1111/j.1365-2567.2011.03501.x.
- Arjona A, Wang P, Montgomery RR, Fikrig E. Innate immune control of West Nile virus infection. Cellular Microbiology 2011, 13: 1648-58. PMID: 21790942, PMCID: PMC3196381, DOI: 10.1111/j.1462-5822.2011.01649.x.
- Liu L, Narasimhan S, Dai J, Zhang L, Cheng G, Fikrig E. Ixodes scapularis salivary gland protein P11 facilitates migration of Anaplasma phagocytophilum from the tick gut to salivary glands. EMBO Reports 2011, 12: 1196-203. PMID: 21921936, PMCID: PMC3207102, DOI: 10.1038/embor.2011.177.
- Colpitts TM, Rodenhuis-Zybert I, Moesker B, Wang P, Fikrig E, Smit JM. prM-antibody renders immature West Nile virus infectious in vivo. The Journal Of General Virology 2011, 92: 2281-2285. PMID: 21697345, PMCID: PMC3347797, DOI: 10.1099/vir.0.031427-0.
- Colpitts TM, Cox J, Vanlandingham DL, Feitosa FM, Cheng G, Kurscheid S, Wang P, Krishnan MN, Higgs S, Fikrig E. Alterations in the Aedes aegypti transcriptome during infection with West Nile, dengue and yellow fever viruses. PLoS Pathogens 2011, 7: e1002189. PMID: 21909258, PMCID: PMC3164632, DOI: 10.1371/journal.ppat.1002189.
- Schuijt TJ, Coumou J, Narasimhan S, Dai J, Deponte K, Wouters D, Brouwer M, Oei A, Roelofs JJ, van Dam AP, van der Poll T, Van't Veer C, Hovius JW, Fikrig E. A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent. Cell Host & Microbe 2011, 10: 136-46. PMID: 21843870, PMCID: PMC3170916, DOI: 10.1016/j.chom.2011.06.010.
- Colpitts TM, Cox J, Nguyen A, Feitosa F, Krishnan MN, Fikrig E. Use of a tandem affinity purification assay to detect interactions between West Nile and dengue viral proteins and proteins of the mosquito vector. Virology 2011, 417: 179-87. PMID: 21700306, PMCID: PMC3166580, DOI: 10.1016/j.virol.2011.06.002.
- Zhang L, Zhang Y, Adusumilli S, Liu L, Narasimhan S, Dai J, Zhao YO, Fikrig E. Molecular interactions that enable movement of the Lyme disease agent from the tick gut into the hemolymph. PLoS Pathogens 2011, 7: e1002079. PMID: 21695244, PMCID: PMC3111543, DOI: 10.1371/journal.ppat.1002079.
- Qian F, Wang X, Zhang L, Lin A, Zhao H, Fikrig E, Montgomery RR. Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus. The Journal Of Infectious Diseases 2011, 203: 1415-24. PMID: 21398396, PMCID: PMC3080893, DOI: 10.1093/infdis/jir048.
- van Burgel ND, Balmus NC, Fikrig E, van Dam AP. Infectivity of Borrelia burgdorferi sensu lato is unaltered in C3-deficient mice. Ticks And Tick-borne Diseases 2011, 2: 20-6. PMID: 21771533, DOI: 10.1016/j.ttbdis.2010.10.003.
- Schuijt TJ, Narasimhan S, Daffre S, DePonte K, Hovius JW, Van't Veer C, van der Poll T, Bakhtiari K, Meijers JC, Boder ET, van Dam AP, Fikrig E. Identification and characterization of Ixodes scapularis antigens that elicit tick immunity using yeast surface display. PloS One 2011, 6: e15926. PMID: 21246036, PMCID: PMC3016337, DOI: 10.1371/journal.pone.0015926.
- Sukumaran B, Mastronunzio JE, Narasimhan S, Fankhauser S, Uchil PD, Levy R, Graham M, Colpitts TM, Lesser CF, Fikrig E. Anaplasma phagocytophilum AptA modulates Erk1/2 signalling. Cellular Microbiology 2011, 13: 47-61. PMID: 20716207, PMCID: PMC3005019, DOI: 10.1111/j.1462-5822.2010.01516.x.
- Cheng G, Liu L, Wang P, Zhang Y, Zhao YO, Colpitts TM, Feitosa F, Anderson JF, Fikrig E. An in vivo transfection approach elucidates a role for Aedes aegypti thioester-containing proteins in flaviviral infection. PloS One 2011, 6: e22786. PMID: 21818390, PMCID: PMC3144946, DOI: 10.1371/journal.pone.0022786.
- Colpitts TM, Barthel S, Wang P, Fikrig E. Dengue virus capsid protein binds core histones and inhibits nucleosome formation in human liver cells. PloS One 2011, 6: e24365. PMID: 21909430, PMCID: PMC3164731, DOI: 10.1371/journal.pone.0024365.
- Schuijt TJ, Hovius JW, van der Poll T, van Dam AP, Fikrig E. Lyme borreliosis vaccination: the facts, the challenge, the future. Trends In Parasitology 2011, 27: 40-7. PMID: 20594913, DOI: 10.1016/j.pt.2010.06.006.
- Bai F, Kong KF, Dai J, Qian F, Zhang L, Brown CR, Fikrig E, Montgomery RR. A paradoxical role for neutrophils in the pathogenesis of West Nile virus. The Journal Of Infectious Diseases 2010, 202: 1804-12. PMID: 21050124, PMCID: PMC3053000, DOI: 10.1086/657416.
- Dai J, Narasimhan S, Zhang L, Liu L, Wang P, Fikrig E. Tick histamine release factor is critical for Ixodes scapularis engorgement and transmission of the lyme disease agent. PLoS Pathogens 2010, 6: e1001205. PMID: 21124826, PMCID: PMC2991271, DOI: 10.1371/journal.ppat.1001205.
- Wang P, Arjona A, Zhang Y, Sultana H, Dai J, Yang L, LeBlanc PM, Doiron K, Saleh M, Fikrig E. Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I. Nature Immunology 2010, 11: 912-9. PMID: 20818395, PMCID: PMC3712356, DOI: 10.1038/ni.1933.
- Cheng G, Cox J, Wang P, Krishnan MN, Dai J, Qian F, Anderson JF, Fikrig E. A C-type lectin collaborates with a CD45 phosphatase homolog to facilitate West Nile virus infection of mosquitoes. Cell 2010, 142: 714-25. PMID: 20797779, PMCID: PMC2954371, DOI: 10.1016/j.cell.2010.07.038.
- Pedra JH, Narasimhan S, Rendić D, DePonte K, Bell-Sakyi L, Wilson IB, Fikrig E. Fucosylation enhances colonization of ticks by Anaplasma phagocytophilum. Cellular Microbiology 2010, 12: 1222-34. PMID: 20331643, PMCID: PMC3250644, DOI: 10.1111/j.1462-5822.2010.01464.x.
- Demento SL, Bonafé N, Cui W, Kaech SM, Caplan MJ, Fikrig E, Ledizet M, Fahmy TM. TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitis. Journal Of Immunology (Baltimore, Md. : 1950) 2010, 185: 2989-97. PMID: 20660705, PMCID: PMC3753007, DOI: 10.4049/jimmunol.1000768.
- Neelakanta G, Sultana H, Fish D, Anderson JF, Fikrig E. Anaplasma phagocytophilum induces Ixodes scapularis ticks to express an antifreeze glycoprotein gene that enhances their survival in the cold. The Journal Of Clinical Investigation 2010, 120: 3179-90. PMID: 20739755, PMCID: PMC2929727, DOI: 10.1172/JCI42868.
- Sultana H, Neelakanta G, Kantor FS, Malawista SE, Fish D, Montgomery RR, Fikrig E. Anaplasma phagocytophilum induces actin phosphorylation to selectively regulate gene transcription in Ixodes scapularis ticks. The Journal Of Experimental Medicine 2010, 207: 1727-43. PMID: 20660616, PMCID: PMC2916137, DOI: 10.1084/jem.20100276.
- Magnarelli LA, Williams SC, Fikrig E. Seasonal prevalence of serum antibodies to whole cell and recombinant antigens of Borrelia burgdorferi and Anaplasma phagocytophilum in white-tailed deer in Connecticut. Journal Of Wildlife Diseases 2010, 46: 781-90. PMID: 20688684, DOI: 10.7589/0090-3558-46.3.781.
- Dunne DW, Shaw A, Bockenstedt LK, Allore HG, Chen S, Malawista SE, Leng L, Mizue Y, Piecychna M, Zhang L, Towle V, Bucala R, Montgomery RR, Fikrig E. Increased TLR4 expression and downstream cytokine production in immunosuppressed adults compared to non-immunosuppressed adults. PloS One 2010, 5: e11343. PMID: 20596538, PMCID: PMC2893205, DOI: 10.1371/journal.pone.0011343.
- Panda A, Qian F, Mohanty S, van Duin D, Newman FK, Zhang L, Chen S, Towle V, Belshe RB, Fikrig E, Allore HG, Montgomery RR, Shaw AC. Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. Journal Of Immunology (Baltimore, Md. : 1950) 2010, 184: 2518-27. PMID: 20100933, PMCID: PMC3867271, DOI: 10.4049/jimmunol.0901022.
- Adusumilli S, Booth CJ, Anguita J, Fikrig E. Passage through Ixodes scapularis ticks enhances the virulence of a weakly pathogenic isolate of Borrelia burgdorferi. Infection And Immunity 2010, 78: 138-44. PMID: 19822652, PMCID: PMC2798202, DOI: 10.1128/IAI.00470-09.
- Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ. The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell 2009, 139: 1243-54. PMID: 20064371, PMCID: PMC2824905, DOI: 10.1016/j.cell.2009.12.017.
- Dai J, Wang P, Adusumilli S, Booth CJ, Narasimhan S, Anguita J, Fikrig E. Antibodies against a tick protein, Salp15, protect mice from the Lyme disease agent. Cell Host & Microbe 2009, 6: 482-92. PMID: 19917502, PMCID: PMC2843562, DOI: 10.1016/j.chom.2009.10.006.
- Fikrig E, Narasimhan S, Neelakanta G, Pal U, Chen M, Flavell R. Toll-like receptors 1 and 2 heterodimers alter Borrelia burgdorferi gene expression in mice and ticks. The Journal Of Infectious Diseases 2009, 200: 1331-40. PMID: 19754309, PMCID: PMC2846271, DOI: 10.1086/605950.
- Bai F, Town T, Qian F, Wang P, Kamanaka M, Connolly TM, Gate D, Montgomery RR, Flavell RA, Fikrig E. IL-10 signaling blockade controls murine West Nile virus infection. PLoS Pathogens 2009, 5: e1000610. PMID: 19816558, PMCID: PMC2749443, DOI: 10.1371/journal.ppat.1000610.
- Panda A, Arjona A, Sapey E, Bai F, Fikrig E, Montgomery RR, Lord JM, Shaw AC. Human innate immunosenescence: causes and consequences for immunity in old age. Trends In Immunology 2009, 30: 325-33. PMID: 19541535, PMCID: PMC4067971, DOI: 10.1016/j.it.2009.05.004.
- Sultana H, Foellmer HG, Neelakanta G, Oliphant T, Engle M, Ledizet M, Krishnan MN, Bonafé N, Anthony KG, Marasco WA, Kaplan P, Montgomery RR, Diamond MS, Koski RA, Fikrig E. Fusion loop peptide of the West Nile virus envelope protein is essential for pathogenesis and is recognized by a therapeutic cross-reactive human monoclonal antibody. Journal Of Immunology (Baltimore, Md. : 1950) 2009, 183: 650-60. PMID: 19535627, PMCID: PMC3690769, DOI: 10.4049/jimmunol.0900093.
- Anthony KG, Bai F, Krishnan MN, Fikrig E, Koski RA. Effective siRNA targeting of the 3' untranslated region of the West Nile virus genome. Antiviral Research 2009, 82: 166-8. PMID: 19135091, DOI: 10.1016/j.antiviral.2008.12.007.
- Guo X, Booth CJ, Paley MA, Wang X, DePonte K, Fikrig E, Narasimhan S, Montgomery RR. Inhibition of neutrophil function by two tick salivary proteins. Infection And Immunity 2009, 77: 2320-9. PMID: 19332533, PMCID: PMC2687334, DOI: 10.1128/IAI.01507-08.
- Demento SL, Eisenbarth SC, Foellmer HG, Platt C, Caplan MJ, Mark Saltzman W, Mellman I, Ledizet M, Fikrig E, Flavell RA, Fahmy TM. Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy. Vaccine 2009, 27: 3013-21. PMID: 19428913, PMCID: PMC2695996, DOI: 10.1016/j.vaccine.2009.03.034.
- Hovius JW, Bijlsma MF, van der Windt GJ, Wiersinga WJ, Boukens BJ, Coumou J, Oei A, de Beer R, de Vos AF, van 't Veer C, van Dam AP, Wang P, Fikrig E, Levi MM, Roelofs JJ, van der Poll T. The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi. PLoS Pathogens 2009, 5: e1000447. PMID: 19461880, PMCID: PMC2678258, DOI: 10.1371/journal.ppat.1000447.
- Town T, Bai F, Wang T, Kaplan AT, Qian F, Montgomery RR, Anderson JF, Flavell RA, Fikrig E. Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. Immunity 2009, 30: 242-53. PMID: 19200759, PMCID: PMC2707901, DOI: 10.1016/j.immuni.2008.11.012.
- Bonafé N, Rininger JA, Chubet RG, Foellmer HG, Fader S, Anderson JF, Bushmich SL, Anthony K, Ledizet M, Fikrig E, Koski RA, Kaplan P. A recombinant West Nile virus envelope protein vaccine candidate produced in Spodoptera frugiperda expresSF+ cells. Vaccine 2009, 27: 213-22. PMID: 18996430, PMCID: PMC2651515, DOI: 10.1016/j.vaccine.2008.10.046.
- Thomas V, Samanta S, Fikrig E. Anaplasma phagocytophilum increases cathepsin L activity, thereby globally influencing neutrophil function. Infection And Immunity 2008, 76: 4905-12. PMID: 18765732, PMCID: PMC2573316, DOI: 10.1128/IAI.00851-08.
- Hovius JW, Schuijt TJ, de Groot KA, Roelofs JJ, Oei GA, Marquart JA, de Beer R, van 't Veer C, van der Poll T, Ramamoorthi N, Fikrig E, van Dam AP. Preferential protection of Borrelia burgdorferi sensu stricto by a Salp15 homologue in Ixodes ricinus saliva. The Journal Of Infectious Diseases 2008, 198: 1189-97. PMID: 18752445, PMCID: PMC4317250, DOI: 10.1086/591917.
- Yang X, Izadi H, Coleman AS, Wang P, Ma Y, Fikrig E, Anguita J, Pal U. Borrelia burgdorferi lipoprotein BmpA activates pro-inflammatory responses in human synovial cells through a protein moiety. Microbes And Infection / Institut Pasteur 2008, 10: 1300-8. PMID: 18725314, PMCID: PMC2648844, DOI: 10.1016/j.micinf.2008.07.029.
- Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, Sultana H, Brass AL, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason PW, Koski RA, Elledge SJ, Xavier RJ, Agaisse H, Fikrig E. RNA interference screen for human genes associated with West Nile virus infection. Nature 2008, 455: 242-5. PMID: 18690214, PMCID: PMC3136529, DOI: 10.1038/nature07207.
- Wang P, Dai J, Bai F, Kong KF, Wong SJ, Montgomery RR, Madri JA, Fikrig E. Matrix metalloproteinase 9 facilitates West Nile virus entry into the brain. Journal Of Virology 2008, 82: 8978-85. PMID: 18632868, PMCID: PMC2546894, DOI: 10.1128/JVI.00314-08.
- Kong KF, Delroux K, Wang X, Qian F, Arjona A, Malawista SE, Fikrig E, Montgomery RR. Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly. Journal Of Virology 2008, 82: 7613-23. PMID: 18508883, PMCID: PMC2493309, DOI: 10.1128/JVI.00618-08.
- Wang S, Welte T, McGargill M, Town T, Thompson J, Anderson JF, Flavell RA, Fikrig E, Hedrick SM, Wang T. Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis. Journal Of Immunology (Baltimore, Md. : 1950) 2008, 181: 2084-91. PMID: 18641347, PMCID: PMC2494872, DOI: 10.4049/jimmunol.181.3.2084.
- Schuijt TJ, Hovius JW, van Burgel ND, Ramamoorthi N, Fikrig E, van Dam AP. The tick salivary protein Salp15 inhibits the killing of serum-sensitive Borrelia burgdorferi sensu lato isolates. Infection And Immunity 2008, 76: 2888-94. PMID: 18426890, PMCID: PMC2446733, DOI: 10.1128/IAI.00232-08.
- Anderson JF, Main AJ, Delroux K, Fikrig E. Extrinsic incubation periods for horizontal and vertical transmission of West Nile virus by Culex pipiens pipiens (Diptera: Culicidae). Journal Of Medical Entomology 2008, 45: 445-51. PMID: 18533438, DOI: 10.1603/0022-2585(2008)45[445:eipfha]2.0.co;2.
- Dai J, Wang P, Bai F, Town T, Fikrig E. Icam-1 participates in the entry of west nile virus into the central nervous system. Journal Of Virology 2008, 82: 4164-8. PMID: 18256150, PMCID: PMC2292986, DOI: 10.1128/JVI.02621-07.
- Kong KF, Wang X, Anderson JF, Fikrig E, Montgomery RR. West nile virus attenuates activation of primary human macrophages. Viral Immunology 2008, 21: 78-82. PMID: 18355125, PMCID: PMC2666911, DOI: 10.1089/vim.2007.0072.
- Hovius JW, de Jong MA, den Dunnen J, Litjens M, Fikrig E, van der Poll T, Gringhuis SI, Geijtenbeek TB. Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization. PLoS Pathogens 2008, 4: e31. PMID: 18282094, PMCID: PMC2242833, DOI: 10.1371/journal.ppat.0040031.
- Hovius JW, Levi M, Fikrig E. Salivating for knowledge: potential pharmacological agents in tick saliva. PLoS Medicine 2008, 5: e43. PMID: 18271624, PMCID: PMC2235897, DOI: 10.1371/journal.pmed.0050043.
- Pal U, Wang P, Bao F, Yang X, Samanta S, Schoen R, Wormser GP, Schwartz I, Fikrig E. Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis. The Journal Of Experimental Medicine 2008, 205: 133-41. PMID: 18166585, PMCID: PMC2234379, DOI: 10.1084/jem.20070962.
- Pedra JH, Mattner J, Tao J, Kerfoot SM, Davis RJ, Flavell RA, Askenase PW, Yin Z, Fikrig E. c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection. Infection And Immunity 2008, 76: 308-16. PMID: 17998313, PMCID: PMC2223674, DOI: 10.1128/IAI.00599-07.
- Pal U, Dai J, Li X, Neelakanta G, Luo P, Kumar M, Wang P, Yang X, Anderson JF, Fikrig E. A differential role for BB0365 in the persistence of Borrelia burgdorferi in mice and ticks. The Journal Of Infectious Diseases 2008, 197: 148-55. PMID: 18171298, DOI: 10.1086/523764.
- Arjona A, Ledizet M, Anthony K, Bonafé N, Modis Y, Town T, Fikrig E. West Nile virus envelope protein inhibits dsRNA-induced innate immune responses. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 179: 8403-9. PMID: 18056386, DOI: 10.4049/jimmunol.179.12.8403.
- Ledizet M, Kar K, Foellmer HG, Bonafé N, Anthony KG, Gould LH, Bushmich SL, Fikrig E, Koski RA. Antibodies targeting linear determinants of the envelope protein protect mice against West Nile virus. The Journal Of Infectious Diseases 2007, 196: 1741-8. PMID: 18190253, DOI: 10.1086/523654.
- Arjona A, Foellmer HG, Town T, Leng L, McDonald C, Wang T, Wong SJ, Montgomery RR, Fikrig E, Bucala R. Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion. The Journal Of Clinical Investigation 2007, 117: 3059-66. PMID: 17909632, PMCID: PMC1994625, DOI: 10.1172/JCI32218.
- Pedra JH, Sutterwala FS, Sukumaran B, Ogura Y, Qian F, Montgomery RR, Flavell RA, Fikrig E. ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 179: 4783-91. PMID: 17878377, DOI: 10.4049/jimmunol.179.7.4783.
- Hovius JW, Ramamoorthi N, Van't Veer C, de Groot KA, Nijhof AM, Jongejan F, van Dam AP, Fikrig E. Identification of Salp15 homologues in Ixodes ricinus ticks. Vector Borne And Zoonotic Diseases (Larchmont, N.Y.) 2007, 7: 296-303. PMID: 17896872, DOI: 10.1089/vbz.2006.0624.
- Li X, Neelakanta G, Liu X, Beck DS, Kantor FS, Fish D, Anderson JF, Fikrig E. Role of outer surface protein D in the Borrelia burgdorferi life cycle. Infection And Immunity 2007, 75: 4237-44. PMID: 17620358, PMCID: PMC1951184, DOI: 10.1128/IAI.00632-07.
- Hovius JW, van Dam AP, Fikrig E. Tick-host-pathogen interactions in Lyme borreliosis. Trends In Parasitology 2007, 23: 434-8. PMID: 17656156, DOI: 10.1016/j.pt.2007.07.001.
- Pedra JH, Tao J, Sutterwala FS, Sukumaran B, Berliner N, Bockenstedt LK, Flavell RA, Yin Z, Fikrig E. IL-12/23p40-dependent clearance of Anaplasma phagocytophilum in the murine model of human anaplasmosis. FEMS Immunology And Medical Microbiology 2007, 50: 401-10. PMID: 17521390, DOI: 10.1111/j.1574-695X.2007.00270.x.
- Tyson K, Elkins C, Patterson H, Fikrig E, de Silva A. Biochemical and functional characterization of Salp20, an Ixodes scapularis tick salivary protein that inhibits the complement pathway. Insect Molecular Biology 2007, 16: 469-79. PMID: 17651236, DOI: 10.1111/j.1365-2583.2007.00742.x.
- Narasimhan S, Sukumaran B, Bozdogan U, Thomas V, Liang X, DePonte K, Marcantonio N, Koski RA, Anderson JF, Kantor F, Fikrig E. A tick antioxidant facilitates the Lyme disease agent's successful migration from the mammalian host to the arthropod vector. Cell Host & Microbe 2007, 2: 7-18. PMID: 18005713, PMCID: PMC2699493, DOI: 10.1016/j.chom.2007.06.001.
- Thomas V, Fikrig E. Anaplasma phagocytophilum specifically induces tyrosine phosphorylation of ROCK1 during infection. Cellular Microbiology 2007, 9: 1730-7. PMID: 17346310, DOI: 10.1111/j.1462-5822.2007.00908.x.
- McDonald WF, Huleatt JW, Foellmer HG, Hewitt D, Tang J, Desai P, Price A, Jacobs A, Takahashi VN, Huang Y, Nakaar V, Alexopoulou L, Fikrig E, Powell TJ. A West Nile virus recombinant protein vaccine that coactivates innate and adaptive immunity. The Journal Of Infectious Diseases 2007, 195: 1607-17. PMID: 17471430, DOI: 10.1086/517613.
- Narasimhan S, Deponte K, Marcantonio N, Liang X, Royce TE, Nelson KF, Booth CJ, Koski B, Anderson JF, Kantor F, Fikrig E. Immunity against Ixodes scapularis salivary proteins expressed within 24 hours of attachment thwarts tick feeding and impairs Borrelia transmission. PloS One 2007, 2: e451. PMID: 17505544, PMCID: PMC1866177, DOI: 10.1371/journal.pone.0000451.
- Krishnan MN, Sukumaran B, Pal U, Agaisse H, Murray JL, Hodge TW, Fikrig E. Rab 5 is required for the cellular entry of dengue and West Nile viruses. Journal Of Virology 2007, 81: 4881-5. PMID: 17301152, PMCID: PMC1900185, DOI: 10.1128/JVI.02210-06.
- Neelakanta G, Li X, Pal U, Liu X, Beck DS, DePonte K, Fish D, Kantor FS, Fikrig E. Outer surface protein B is critical for Borrelia burgdorferi adherence and survival within Ixodes ticks. PLoS Pathogens 2007, 3: e33. PMID: 17352535, PMCID: PMC1817655, DOI: 10.1371/journal.ppat.0030033.
- Hovius JW, Li X, Ramamoorthi N, van Dam AP, Barthold SW, van der Poll T, Speelman P, Fikrig E. Coinfection with Borrelia burgdorferi sensu stricto and Borrelia garinii alters the course of murine Lyme borreliosis. FEMS Immunology And Medical Microbiology 2007, 49: 224-34. PMID: 17328756, DOI: 10.1111/j.1574-695X.2006.00177.x.
- Bai F, Town T, Pradhan D, Cox J, Ashish, Ledizet M, Anderson JF, Flavell RA, Krueger JK, Koski RA, Fikrig E. Antiviral peptides targeting the west nile virus envelope protein. Journal Of Virology 2007, 81: 2047-55. PMID: 17151121, PMCID: PMC1797586, DOI: 10.1128/JVI.01840-06.
- Li X, Pal U, Ramamoorthi N, Liu X, Desrosiers DC, Eggers CH, Anderson JF, Radolf JD, Fikrig E. The Lyme disease agent Borrelia burgdorferi requires BB0690, a Dps homologue, to persist within ticks. Molecular Microbiology 2007, 63: 694-710. PMID: 17181780, DOI: 10.1111/j.1365-2958.2006.05550.x.
- van Duin D, Mohanty S, Thomas V, Ginter S, Montgomery RR, Fikrig E, Allore HG, Medzhitov R, Shaw AC. Age-associated defect in human TLR-1/2 function. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 178: 970-5. PMID: 17202359, DOI: 10.4049/jimmunol.178.2.970.
- Garg R, Juncadella IJ, Ramamoorthi N, Ashish, Ananthanarayanan SK, Thomas V, Rincón M, Krueger JK, Fikrig E, Yengo CM, Anguita J. Cutting edge: CD4 is the receptor for the tick saliva immunosuppressor, Salp15. Journal Of Immunology (Baltimore, Md. : 1950) 2006, 177: 6579-83. PMID: 17082567, PMCID: PMC4302324, DOI: 10.4049/jimmunol.177.10.6579.
- Kanai R, Kar K, Anthony K, Gould LH, Ledizet M, Fikrig E, Marasco WA, Koski RA, Modis Y. Crystal structure of west nile virus envelope glycoprotein reveals viral surface epitopes. Journal Of Virology 2006, 80: 11000-8. PMID: 16943291, PMCID: PMC1642136, DOI: 10.1128/JVI.01735-06.
- Pedra JH, Narasimhan S, Deponte K, Marcantonio N, Kantor FS, Fikrig E. Disruption of the salivary protein 14 in Ixodes scapularis nymphs and impact on pathogen acquisition. The American Journal Of Tropical Medicine And Hygiene 2006, 75: 677-82. PMID: 17038693.
- Magnarelli LA, Stafford KC, Ijdo JW, Fikrig E. Antibodies to whole-cell or recombinant antigens of Borrelia burgdorferi, Anaplasma phagocytophilum, and Babesia microti in white-footed mice. Journal Of Wildlife Diseases 2006, 42: 732-8. PMID: 17255439, DOI: 10.7589/0090-3558-42.4.732.
- Wang T, Gao Y, Scully E, Davis CT, Anderson JF, Welte T, Ledizet M, Koski R, Madri JA, Barrett A, Yin Z, Craft J, Fikrig E. Gamma delta T cells facilitate adaptive immunity against West Nile virus infection in mice. Journal Of Immunology (Baltimore, Md. : 1950) 2006, 177: 1825-32. PMID: 16849493, DOI: 10.4049/jimmunol.177.3.1825.
- Sukumaran B, Narasimhan S, Anderson JF, DePonte K, Marcantonio N, Krishnan MN, Fish D, Telford SR, Kantor FS, Fikrig E. An Ixodes scapularis protein required for survival of Anaplasma phagocytophilum in tick salivary glands. The Journal Of Experimental Medicine 2006, 203: 1507-17. PMID: 16717118, PMCID: PMC2118316, DOI: 10.1084/jem.20060208.
- Shrestha B, Wang T, Samuel MA, Whitby K, Craft J, Fikrig E, Diamond MS. Gamma interferon plays a crucial early antiviral role in protection against West Nile virus infection. Journal Of Virology 2006, 80: 5338-48. PMID: 16699014, PMCID: PMC1472130, DOI: 10.1128/JVI.00274-06.
- Li X, Liu X, Beck DS, Kantor FS, Fikrig E. Borrelia burgdorferi lacking BBK32, a fibronectin-binding protein, retains full pathogenicity. Infection And Immunity 2006, 74: 3305-13. PMID: 16714558, PMCID: PMC1479267, DOI: 10.1128/IAI.02035-05.
- Fikrig E, Narasimhan S. Borrelia burgdorferi--traveling incognito? Microbes And Infection / Institut Pasteur 2006, 8: 1390-9. PMID: 16698304, DOI: 10.1016/j.micinf.2005.12.022.
- Carlyon JA, Fikrig E. Mechanisms of evasion of neutrophil killing by Anaplasma phagocytophilum. Current Opinion In Hematology 2006, 13: 28-33. PMID: 16319684, DOI: 10.1097/01.moh.0000190109.00532.56.
- Sukumaran B, Carlyon JA, Cai JL, Berliner N, Fikrig E. Early transcriptional response of human neutrophils to Anaplasma phagocytophilum infection. Infection And Immunity 2005, 73: 8089-99. PMID: 16299303, PMCID: PMC1307096, DOI: 10.1128/IAI.73.12.8089-8099.2005.
- Gould LH, Sui J, Foellmer H, Oliphant T, Wang T, Ledizet M, Murakami A, Noonan K, Lambeth C, Kar K, Anderson JF, de Silva AM, Diamond MS, Koski RA, Marasco WA, Fikrig E. Protective and therapeutic capacity of human single-chain Fv-Fc fusion proteins against West Nile virus. Journal Of Virology 2005, 79: 14606-13. PMID: 16282460, PMCID: PMC1287547, DOI: 10.1128/JVI.79.23.14606-14613.2005.
- Carlyon JA, Ryan D, Archer K, Fikrig E. Effects of Anaplasma phagocytophilum on host cell ferritin mRNA and protein levels. Infection And Immunity 2005, 73: 7629-36. PMID: 16239567, PMCID: PMC1273867, DOI: 10.1128/IAI.73.11.7629-7636.2005.
- Xu Q, Seemanapalli SV, Lomax L, McShan K, Li X, Fikrig E, Liang FT. Association of linear plasmid 28-1 with an arthritic phenotype of Borrelia burgdorferi. Infection And Immunity 2005, 73: 7208-15. PMID: 16239515, PMCID: PMC1273894, DOI: 10.1128/IAI.73.11.7208-7215.2005.
- Magnarelli LA, Bushmich SL, IJdo JW, Fikrig E. Seroprevalence of antibodies against Borrelia burgdorferi and Anaplasma phagocytophilum in cats. American Journal Of Veterinary Research 2005, 66: 1895-9. PMID: 16334946, DOI: 10.2460/ajvr.2005.66.1895.
- Magnarelli L, Fikrig E. Detection of antibodies to Borrelia burgdorferi in naturally infected horses in the USA by enzyme-linked immunosorbent assay using whole-cell and recombinant antigens. Research In Veterinary Science 2005, 79: 99-103. PMID: 15924926, DOI: 10.1016/j.rvsc.2004.11.009.
- Pedra JH, Sukumaran B, Carlyon JA, Berliner N, Fikrig E. Modulation of NB4 promyelocytic leukemic cell machinery by Anaplasma phagocytophilum. Genomics 2005, 86: 365-77. PMID: 16005178, DOI: 10.1016/j.ygeno.2005.05.008.
- Ramamoorthi N, Narasimhan S, Pal U, Bao F, Yang XF, Fish D, Anguita J, Norgard MV, Kantor FS, Anderson JF, Koski RA, Fikrig E. The Lyme disease agent exploits a tick protein to infect the mammalian host. Nature 2005, 436: 573-7. PMID: 16049492, PMCID: PMC4306560, DOI: 10.1038/nature03812.
- Ledizet M, Kar K, Foellmer HG, Wang T, Bushmich SL, Anderson JF, Fikrig E, Koski RA. A recombinant envelope protein vaccine against West Nile virus. Vaccine 2005, 23: 3915-24. PMID: 15917113, DOI: 10.1016/j.vaccine.2005.03.006.
- Bai F, Wang T, Pal U, Bao F, Gould LH, Fikrig E. Use of RNA interference to prevent lethal murine west nile virus infection. The Journal Of Infectious Diseases 2005, 191: 1148-54. PMID: 15747251, DOI: 10.1086/428507.
- Thomas V, Samanta S, Wu C, Berliner N, Fikrig E. Anaplasma phagocytophilum modulates gp91phox gene expression through altered interferon regulatory factor 1 and PU.1 levels and binding of CCAAT displacement protein. Infection And Immunity 2005, 73: 208-18. PMID: 15618156, PMCID: PMC538944, DOI: 10.1128/IAI.73.1.208-218.2005.
- Wang T, Town T, Alexopoulou L, Anderson JF, Fikrig E, Flavell RA. Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nature Medicine 2004, 10: 1366-73. PMID: 15558055, DOI: 10.1038/nm1140.
- Pal U, Li X, Wang T, Montgomery RR, Ramamoorthi N, Desilva AM, Bao F, Yang X, Pypaert M, Pradhan D, Kantor FS, Telford S, Anderson JF, Fikrig E. TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi. Cell 2004, 119: 457-68. PMID: 15537536, DOI: 10.1016/j.cell.2004.10.027.
- Wang T, Akkoyunlu M, Banerjee R, Fikrig E. Interferon-gamma deficiency reveals that 129Sv mice are inherently more susceptible to Anaplasma phagocytophilum than C57BL/6 mice. FEMS Immunology And Medical Microbiology 2004, 42: 299-305. PMID: 15477043, DOI: 10.1016/j.femsim.2004.06.001.
- Liang FT, Yan J, Mbow ML, Sviat SL, Gilmore RD, Mamula M, Fikrig E. Borrelia burgdorferi changes its surface antigenic expression in response to host immune responses. Infection And Immunity 2004, 72: 5759-67. PMID: 15385475, PMCID: PMC517580, DOI: 10.1128/IAI.72.10.5759-5767.2004.
- Liang FT, Brown EL, Wang T, Iozzo RV, Fikrig E. Protective niche for Borrelia burgdorferi to evade humoral immunity. The American Journal Of Pathology 2004, 165: 977-85. PMID: 15331421, PMCID: PMC1618599, DOI: 10.1016/S0002-9440(10)63359-7.
- Scorpio DG, Akkoyunlu M, Fikrig E, Dumler JS. CXCR2 blockade influences Anaplasma phagocytophilum propagation but not histopathology in the mouse model of human granulocytic anaplasmosis. Clinical And Diagnostic Laboratory Immunology 2004, 11: 963-8. PMID: 15358660, PMCID: PMC515272, DOI: 10.1128/CDLI.11.5.963-968.2004.
- Magnarelli LA, Bushmich SL, Sherman BA, Fikrig E. A comparison of serologic tests for the detection of serum antibodies to whole-cell and recombinant Borrelia burgdorferi antigens in cattle. The Canadian Veterinary Journal = La Revue Veterinaire Canadienne 2004, 45: 667-73. PMID: 15368740, PMCID: PMC546445.
- Carlyon JA, Abdel-Latif D, Pypaert M, Lacy P, Fikrig E. Anaplasma phagocytophilum utilizes multiple host evasion mechanisms to thwart NADPH oxidase-mediated killing during neutrophil infection. Infection And Immunity 2004, 72: 4772-83. PMID: 15271939, PMCID: PMC470610, DOI: 10.1128/IAI.72.8.4772-4783.2004.
- Wang T, Fikrig E. Immunity to West Nile virus. Current Opinion In Immunology 2004, 16: 519-23. PMID: 15245749, DOI: 10.1016/j.coi.2004.05.008.
- Liang FT, Caimano MJ, Radolf JD, Fikrig E. Borrelia burgdorferi outer surface protein (osp) B expression independent of ospA. Microbial Pathogenesis 2004, 37: 35-40. PMID: 15194158, DOI: 10.1016/j.micpath.2004.02.007.
- Gould LH, Fikrig E. West Nile virus: a growing concern? The Journal Of Clinical Investigation 2004, 113: 1102-7. PMID: 15085186, PMCID: PMC385414, DOI: 10.1172/JCI21623.
- Magnarelli LA, IJdo JW, Ramakrishnan U, Henderson DW, Stafford KC, Fikrig E. Use of recombinant antigens of Borrelia burgdorferi and Anaplasma phagocytophilum in enzyme-linked immunosorbent assays to detect antibodies in white-tailed deer. Journal Of Wildlife Diseases 2004, 40: 249-58. PMID: 15362824, DOI: 10.7589/0090-3558-40.2.249.
- Fikrig E, Pal U, Chen M, Anderson JF, Flavell RA. OspB antibody prevents Borrelia burgdorferi colonization of Ixodes scapularis. Infection And Immunity 2004, 72: 1755-9. PMID: 14977984, PMCID: PMC356050, DOI: 10.1128/iai.72.3.1755-1759.2004.
- Fikrig E, Coyle PK, Schutzer SE, Chen M, Deng Z, Flavell RA. Preferential presence of decorin-binding protein B (BBA25) and BBA50 antibodies in cerebrospinal fluid of patients with neurologic Lyme disease. Journal Of Clinical Microbiology 2004, 42: 1243-6. PMID: 15004083, PMCID: PMC356844, DOI: 10.1128/jcm.42.3.1243-1246.2004.
- Yang XF, Pal U, Alani SM, Fikrig E, Norgard MV. Essential role for OspA/B in the life cycle of the Lyme disease spirochete. The Journal Of Experimental Medicine 2004, 199: 641-8. PMID: 14981112, PMCID: PMC2213294, DOI: 10.1084/jem.20031960.
- Narasimhan S, Montgomery RR, DePonte K, Tschudi C, Marcantonio N, Anderson JF, Sauer JR, Cappello M, Kantor FS, Fikrig E. Disruption of Ixodes scapularis anticoagulation by using RNA interference. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 1141-6. PMID: 14745044, PMCID: PMC337020, DOI: 10.1073/pnas.0307669100.
- Pal U, Yang X, Chen M, Bockenstedt LK, Anderson JF, Flavell RA, Norgard MV, Fikrig E. OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands. The Journal Of Clinical Investigation 2004, 113: 220-30. PMID: 14722614, PMCID: PMC311436, DOI: 10.1172/JCI19894.
- Wong SJ, Demarest VL, Boyle RH, Wang T, Ledizet M, Kar K, Kramer LD, Fikrig E, Koski RA. Detection of human anti-flavivirus antibodies with a west nile virus recombinant antigen microsphere immunoassay. Journal Of Clinical Microbiology 2004, 42: 65-72. PMID: 14715733, PMCID: PMC321652, DOI: 10.1128/jcm.42.1.65-72.2004.
- Narasimhan S, Caimano MJ, Liang FT, Santiago F, Laskowski M, Philipp MT, Pachner AR, Radolf JD, Fikrig E. Borrelia burgdorferi transcriptome in the central nervous system of non-human primates. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 15953-8. PMID: 14671329, PMCID: PMC307674, DOI: 10.1073/pnas.2432412100.
- Carlyon JA, Fikrig E. Invasion and survival strategies of Anaplasma phagocytophilum. Cellular Microbiology 2003, 5: 743-54. PMID: 14531890, DOI: 10.1046/j.1462-5822.2003.00323.x.
- Carlyon JA, Akkoyunlu M, Xia L, Yago T, Wang T, Cummings RD, McEver RP, Fikrig E. Murine neutrophils require alpha1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum. Blood 2003, 102: 3387-95. PMID: 12869507, DOI: 10.1182/blood-2003-02-0621.
- Anguita J, Hedrick MN, Fikrig E. Adaptation of Borrelia burgdorferi in the tick and the mammalian host. FEMS Microbiology Reviews 2003, 27: 493-504. PMID: 14550942, DOI: 10.1016/S0168-6445(03)00036-6.
- Yago T, Leppänen A, Carlyon JA, Akkoyunlu M, Karmakar S, Fikrig E, Cummings RD, McEver RP. Structurally distinct requirements for binding of P-selectin glycoprotein ligand-1 and sialyl Lewis x to Anaplasma phagocytophilum and P-selectin. The Journal Of Biological Chemistry 2003, 278: 37987-97. PMID: 12847092, DOI: 10.1074/jbc.M305778200.
- Wang T, Scully E, Yin Z, Kim JH, Wang S, Yan J, Mamula M, Anderson JF, Craft J, Fikrig E. IFN-gamma-producing gamma delta T cells help control murine West Nile virus infection. Journal Of Immunology (Baltimore, Md. : 1950) 2003, 171: 2524-31. PMID: 12928402, DOI: 10.4049/jimmunol.171.5.2524.
- Wong SJ, Boyle RH, Demarest VL, Woodmansee AN, Kramer LD, Li H, Drebot M, Koski RA, Fikrig E, Martin DA, Shi PY. Immunoassay targeting nonstructural protein 5 to differentiate West Nile virus infection from dengue and St. Louis encephalitis virus infections and from flavivirus vaccination. Journal Of Clinical Microbiology 2003, 41: 4217-23. PMID: 12958248, PMCID: PMC193845, DOI: 10.1128/jcm.41.9.4217-4223.2003.
- Pal U, Fikrig E. Adaptation of Borrelia burgdorferi in the vector and vertebrate host. Microbes And Infection / Institut Pasteur 2003, 5: 659-66. PMID: 12787742, DOI: 10.1016/s1286-4579(03)00097-2.
- Welte T, Zhang SS, Wang T, Zhang Z, Hesslein DG, Yin Z, Kano A, Iwamoto Y, Li E, Craft JE, Bothwell AL, Fikrig E, Koni PA, Flavell RA, Fu XY. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 1879-84. PMID: 12571365, PMCID: PMC149927, DOI: 10.1073/pnas.0237137100.
- Schoen RT, Deshefy-Longhi T, Van-Hoecke C, Buscarino C, Fikrig E. An open-label, nonrandomized, single-center, prospective extension, clinical trial of booster dose schedules to assess the safety profile and immunogenicity of recombinant outer-surface protein A (OspA) Lyme disease vaccine. Clinical Therapeutics 2003, 25: 210-24. PMID: 12637121, DOI: 10.1016/s0149-2918(03)90027-0.
- Carlyon JA, Chan WT, Galán J, Roos D, Fikrig E. Repression of rac2 mRNA expression by Anaplasma phagocytophila is essential to the inhibition of superoxide production and bacterial proliferation. Journal Of Immunology (Baltimore, Md. : 1950) 2002, 169: 7009-18. PMID: 12471136, DOI: 10.4049/jimmunol.169.12.7009.
- Narasimhan S, Koski RA, Beaulieu B, Anderson JF, Ramamoorthi N, Kantor F, Cappello M, Fikrig E. A novel family of anticoagulants from the saliva of Ixodes scapularis. Insect Molecular Biology 2002, 11: 641-50. PMID: 12421422, DOI: 10.1046/j.1365-2583.2002.00375.x.
- Anguita J, Samanta S, Ananthanarayanan SK, Revilla B, Geba GP, Barthold SW, Fikrig E. Cyclooxygenase 2 activity modulates the severity of murine Lyme arthritis. FEMS Immunology And Medical Microbiology 2002, 34: 187-91. PMID: 12423770, PMCID: PMC4307933, DOI: 10.1111/j.1574-695X.2002.tb00623.x.
- IJdo JW, Wu C, Telford SR, Fikrig E. Differential expression of the p44 gene family in the agent of human granulocytic ehrlichiosis. Infection And Immunity 2002, 70: 5295-8. PMID: 12183586, PMCID: PMC128253, DOI: 10.1128/iai.70.9.5295-5298.2002.
- Alexopoulou L, Thomas V, Schnare M, Lobet Y, Anguita J, Schoen RT, Medzhitov R, Fikrig E, Flavell RA. Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nature Medicine 2002, 8: 878-84. PMID: 12091878, DOI: 10.1038/nm732.
- Magnarelli LA, Lawrenz M, Norris SJ, Fikrig E. Comparative reactivity of human sera to recombinant VlsE and other Borrelia burgdorferi antigens in class-specific enzyme-linked immunosorbent assays for Lyme borreliosis. Journal Of Medical Microbiology 2002, 51: 649-655. PMID: 12171295, DOI: 10.1099/0022-1317-51-8-649.
- Liang FT, Nelson FK, Fikrig E. Molecular adaptation of Borrelia burgdorferi in the murine host. The Journal Of Experimental Medicine 2002, 196: 275-80. PMID: 12119353, PMCID: PMC2193918, DOI: 10.1084/jem.20020770.
- Wang T, Malawista SE, Pal U, Grey M, Meek J, Akkoyunlu M, Thomas V, Fikrig E. Superoxide anion production during Anaplasma phagocytophila infection. The Journal Of Infectious Diseases 2002, 186: 274-80. PMID: 12134266, DOI: 10.1086/341451.
- Wang T, Magnarelli LA, Anderson JF, Gould LH, Bushmich SL, Wong SJ, Fikrig E. A recombinant envelope protein-based enzyme-linked immunosorbent assay for West Nile virus serodiagnosis. Vector Borne And Zoonotic Diseases (Larchmont, N.Y.) 2002, 2: 105-9. PMID: 12653304, DOI: 10.1089/153036602321131904.
- Anguita J, Barthold SW, Persinski R, Hedrick MN, Huy CA, Davis RJ, Flavell RA, Fikrig E. Murine Lyme arthritis development mediated by p38 mitogen-activated protein kinase activity. Journal Of Immunology (Baltimore, Md. : 1950) 2002, 168: 6352-7. PMID: 12055252, PMCID: PMC4309983, DOI: 10.4049/jimmunol.168.12.6352.
- Anguita J, Ramamoorthi N, Hovius JW, Das S, Thomas V, Persinski R, Conze D, Askenase PW, Rincón M, Kantor FS, Fikrig E. Salp15, an ixodes scapularis salivary protein, inhibits CD4(+) T cell activation. Immunity 2002, 16: 849-59. PMID: 12121666, DOI: 10.1016/s1074-7613(02)00325-4.
- Liang FT, Nelson FK, Fikrig E. DNA microarray assessment of putative Borrelia burgdorferi lipoprotein genes. Infection And Immunity 2002, 70: 3300-3. PMID: 12011030, PMCID: PMC128019, DOI: 10.1128/iai.70.6.3300-3303.2002.
- Narasimhan S, Santiago F, Koski RA, Brei B, Anderson JF, Fish D, Fikrig E. Examination of the Borrelia burgdorferi transcriptome in Ixodes scapularis during feeding. Journal Of Bacteriology 2002, 184: 3122-5. PMID: 12003955, PMCID: PMC135063, DOI: 10.1128/jb.184.11.3122-3125.2002.
- Magnarelli LA, Ijdo JW, Shermant BA, Bushmich SL, Levy SA, Fikrig E. Antibodies to granulocytic ehrlichiae in cattle from Connecticut. Journal Of Medical Microbiology 2002, 51: 326-331. PMID: 11926738, DOI: 10.1099/0022-1317-51-4-326.
- Thomas V, Fikrig E. The Lyme disease vaccine takes its toll. Vector Borne And Zoonotic Diseases (Larchmont, N.Y.) 2002, 2: 217-22. PMID: 12804162, DOI: 10.1089/153036602321653798.
- Wang T, Anderson JF, Magnarelli LA, Bushmich S, Wong S, Koski RA, Fikrig E. West Nile virus envelope protein: role in diagnosis and immunity. Annals Of The New York Academy Of Sciences 2001, 951: 325-7. PMID: 11797789.
- Wang T, Anderson JF, Magnarelli LA, Wong SJ, Koski RA, Fikrig E. Immunization of mice against West Nile virus with recombinant envelope protein. Journal Of Immunology (Baltimore, Md. : 1950) 2001, 167: 5273-7. PMID: 11673542, DOI: 10.4049/jimmunol.167.9.5273.
- Das S, Banerjee G, DePonte K, Marcantonio N, Kantor FS, Fikrig E. Salp25D, an Ixodes scapularis antioxidant, is 1 of 14 immunodominant antigens in engorged tick salivary glands. The Journal Of Infectious Diseases 2001, 184: 1056-64. PMID: 11574922, DOI: 10.1086/323351.
- Magnarelli LA, Levy SA, Ijdo JW, Wu C, Padula SJ, Fikrig E. Reactivity of dog sera to whole-cell or recombinant antigens of Borrelia burgdorferi by ELISA and immunoblot analysis. Journal Of Medical Microbiology 2001, 50: 889-895. PMID: 11599738, DOI: 10.1099/0022-1317-50-10-889.
- Anguita J, Thomas V, Samanta S, Persinski R, Hernanz C, Barthold SW, Fikrig E. Borrelia burgdorferi-induced inflammation facilitates spirochete adaptation and variable major protein-like sequence locus recombination. Journal Of Immunology (Baltimore, Md. : 1950) 2001, 167: 3383-90. PMID: 11544329, PMCID: PMC4309988, DOI: 10.4049/jimmunol.167.6.3383.
- Akkoyunlu M, Malawista SE, Anguita J, Fikrig E. Exploitation of interleukin-8-induced neutrophil chemotaxis by the agent of human granulocytic ehrlichiosis. Infection And Immunity 2001, 69: 5577-88. PMID: 11500432, PMCID: PMC98672, DOI: 10.1128/iai.69.9.5577-5588.2001.
- Magnarelli LA, Ijdo JW, Van Andel AE, Wu C, Oliver JH, Fikrig E. Reactivity of serum samples of dogs and horses tested by use of class-specific recombinant-based enzyme-linked immunosorbent assays for detection of granulocytic ehrlichiosis. American Journal Of Veterinary Research 2001, 62: 1365-9. PMID: 11560261, DOI: 10.2460/ajvr.2001.62.1365.
- De Martino SJ, Carlyon JA, Fikrig E. Coinfection with Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis. The New England Journal Of Medicine 2001, 345: 150-1. PMID: 11450674, DOI: 10.1056/NEJM200107123450218.
- Magnarelli L, Ijdo J, Wu C, Fikrig E. Recombinant protein-44-based class-specific enzyme-linked immunosorbent assays for serologic diagnosis of human granulocytic ehrlichiosis. European Journal Of Clinical Microbiology & Infectious Diseases : Official Publication Of The European Society Of Clinical Microbiology 2001, 20: 482-5. PMID: 11561804, DOI: 10.1007/s100960100542.
- Pal U, Montgomery RR, Lusitani D, Voet P, Weynants V, Malawista SE, Lobet Y, Fikrig E. Inhibition of Borrelia burgdorferi-tick interactions in vivo by outer surface protein A antibody. Journal Of Immunology (Baltimore, Md. : 1950) 2001, 166: 7398-403. PMID: 11390491, DOI: 10.4049/jimmunol.166.12.7398.
- Thomas V, Anguita J, Samanta S, Rosa PA, Stewart P, Barthold SW, Fikrig E. Dissociation of infectivity and pathogenicity in Borrelia burgdorferi. Infection And Immunity 2001, 69: 3507-9. PMID: 11292785, PMCID: PMC98321, DOI: 10.1128/IAI.69.5.3507-3509.2001.
- Thomas V, Anguita J, Barthold SW, Fikrig E. Coinfection with Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis alters murine immune responses, pathogen burden, and severity of Lyme arthritis. Infection And Immunity 2001, 69: 3359-71. PMID: 11292759, PMCID: PMC98295, DOI: 10.1128/IAI.69.5.3359-3371.2001.
- Tsao J, Barbour AG, Luke CJ, Fikrig E, Fish D. OspA immunization decreases transmission of Borrelia burgdorferi spirochetes from infected Peromyscus leucopus mice to larval Ixodes scapularis ticks. Vector Borne And Zoonotic Diseases (Larchmont, N.Y.) 2001, 1: 65-74. PMID: 12653137, DOI: 10.1089/153036601750137705.
- Magnarelli LA, Ijdo JW, Van Andel AE, Wu C, Fikrig E. Evaluation of a polyvalent enzyme-linked immunosorbent assay incorporating a recombinant p44 antigen for diagnosis of granulocytic ehrlichiosis in dogs and horses. American Journal Of Veterinary Research 2001, 62: 29-32. PMID: 11197555, DOI: 10.2460/ajvr.2001.62.29.
- Diehl S, Anguita J, Hoffmeyer A, Zapton T, Ihle JN, Fikrig E, Rincón M. Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1. Immunity 2000, 13: 805-15. PMID: 11163196, DOI: 10.1016/s1074-7613(00)00078-9.
- Ijdo JW, Wu C, Magnarelli LA, Stafford KC, Anderson JF, Fikrig E. Detection of Ehrlichia chaffeensis DNA in Amblyomma americanum ticks in Connecticut and Rhode Island. Journal Of Clinical Microbiology 2000, 38: 4655-6. PMID: 11101616, PMCID: PMC87657, DOI: 10.1128/JCM.38.12.4655-4656.2000.
- Magnarelli LA, Ijdo JW, Van Andel AE, Wu C, Padula SJ, Fikrig E. Serologic confirmation of Ehrlichia equi and Borrelia burgdorferi infections in horses from the northeastern United States. Journal Of The American Veterinary Medical Association 2000, 217: 1045-50. PMID: 11019714, DOI: 10.2460/javma.2000.217.1045.
- Pal U, de Silva AM, Montgomery RR, Fish D, Anguita J, Anderson JF, Lobet Y, Fikrig E. Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A. The Journal Of Clinical Investigation 2000, 106: 561-9. PMID: 10953031, PMCID: PMC380253, DOI: 10.1172/JCI9427.
- Granulocytic ehrlichiosis in mice deficient in phagocyte oxidase or inducible nitric oxide synthase.Banerjee R, Anguita J, Fikrig E. Granulocytic ehrlichiosis in mice deficient in phagocyte oxidase or inducible nitric oxide synthase. Infection And Immunity 2000, 68: 4361-2. PMID: 10858261, PMCID: PMC101771, DOI: 10.1128/iai.68.7.4361-4362.2000.
- Fikrig E, Feng W, Barthold SW, Telford SR, Flavell RA. Arthropod- and host-specific Borrelia burgdorferi bbk32 expression and the inhibition of spirochete transmission. Journal Of Immunology (Baltimore, Md. : 1950) 2000, 164: 5344-51. PMID: 10799897, DOI: 10.4049/jimmunol.164.10.5344.
- Magnarelli LA, Ijdo JW, Padula SJ, Flavell RA, Fikrig E. Serologic diagnosis of Lyme borreliosis by using enzyme-linked immunosorbent assays with recombinant antigens. Journal Of Clinical Microbiology 2000, 38: 1735-9. PMID: 10790090, PMCID: PMC86574, DOI: 10.1128/JCM.38.5.1735-1739.2000.
- Banerjee R, Anguita J, Roos D, Fikrig E. Cutting edge: infection by the agent of human granulocytic ehrlichiosis prevents the respiratory burst by down-regulating gp91phox. Journal Of Immunology (Baltimore, Md. : 1950) 2000, 164: 3946-9. PMID: 10754283, DOI: 10.4049/jimmunol.164.8.3946.
- IJdo JW, Meek JI, Cartter ML, Magnarelli LA, Wu C, Tenuta SW, Fikrig E, Ryder RW. The emergence of another tickborne infection in the 12-town area around Lyme, Connecticut: human granulocytic ehrlichiosis. The Journal Of Infectious Diseases 2000, 181: 1388-93. PMID: 10751139, DOI: 10.1086/315389.
- Akkoyunlu M, Fikrig E. Gamma interferon dominates the murine cytokine response to the agent of human granulocytic ehrlichiosis and helps to control the degree of early rickettsemia. Infection And Immunity 2000, 68: 1827-33. PMID: 10722570, PMCID: PMC97354, DOI: 10.1128/iai.68.4.1827-1833.2000.
- Anguita J, Samanta S, Revilla B, Suk K, Das S, Barthold SW, Fikrig E. Borrelia burgdorferi gene expression in vivo and spirochete pathogenicity. Infection And Immunity 2000, 68: 1222-30. PMID: 10678930, PMCID: PMC97271, DOI: 10.1128/iai.68.3.1222-1230.2000.
- Das S, Marcantonio N, Deponte K, Telford SR, Anderson JF, Kantor FS, Fikrig E. SALP16, a gene induced in Ixodes scapularis salivary glands during tick feeding. The American Journal Of Tropical Medicine And Hygiene 2000, 62: 99-105. PMID: 10761732, DOI: 10.4269/ajtmh.2000.62.99.
- IJdo JW, Wu C, Magnarelli LA, Fikrig E. Serodiagnosis of human granulocytic ehrlichiosis by a recombinant HGE-44-based enzyme-linked immunosorbent assay. Journal Of Clinical Microbiology 1999, 37: 3540-4. PMID: 10523549, PMCID: PMC85687, DOI: 10.1128/JCM.37.11.3540-3544.1999.
- Magnarelli LA, Van Andel AE, Ijdo JW, Heimer R, Fikrig E. Serologic testing of horses for granulocytic ehrlichiosis, using indirect fluorescent antibody staining and immunoblot analysis. American Journal Of Veterinary Research 1999, 60: 631-5. PMID: 10328436.
- van Dobbenburgh A, van Dam AP, Fikrig E. Human granulocytic ehrlichiosis in western Europe. The New England Journal Of Medicine 1999, 340: 1214-6. PMID: 10206853, DOI: 10.1056/NEJM199904153401517.
- Magnarelli LA, Ijdo JW, Stafford KC, Fikrig E. Infections of granulocytic ehrlichiae and Borrelia burgdorferi in white-tailed deer in Connecticut. Journal Of Wildlife Diseases 1999, 35: 266-74. PMID: 10231753, DOI: 10.7589/0090-3558-35.2.266.
- Magnarelli LA, Stafford KC, Ijdo JW, Fikrig E, Oliver JH, Hutcheson HJ, Boone JL. Antibodies to granulocytic ehrlichiae in white-footed and cotton mice in eastern United States. Journal Of Wildlife Diseases 1999, 35: 259-65. PMID: 10231752, DOI: 10.7589/0090-3558-35.2.259.
- Anguita J, Barthold SW, Samanta S, Ryan J, Fikrig E. Selective anti-inflammatory action of interleukin-11 in murine Lyme disease: arthritis decreases while carditis persists. The Journal Of Infectious Diseases 1999, 179: 734-7. PMID: 9952389, DOI: 10.1086/314613.
- Fikrig E, Chen M, Barthold SW, Anguita J, Feng W, Telford SR, Flavell RA. Borrelia burgdorferi erpT expression in the arthropod vector and murine host. Molecular Microbiology 1999, 31: 281-90. PMID: 9987129, DOI: 10.1046/j.1365-2958.1999.01171.x.
- Akin E, McHugh GL, Flavell RA, Fikrig E, Steere AC. The immunoglobulin (IgG) antibody response to OspA and OspB correlates with severe and prolonged Lyme arthritis and the IgG response to P35 correlates with mild and brief arthritis. Infection And Immunity 1999, 67: 173-81. PMID: 9864212, PMCID: PMC96293, DOI: 10.1128/IAI.67.1.173-181.1999.
- de Silva AM, Zeidner NS, Zhang Y, Dolan MC, Piesman J, Fikrig E. Influence of outer surface protein A antibody on Borrelia burgdorferi within feeding ticks. Infection And Immunity 1999, 67: 30-5. PMID: 9864192, PMCID: PMC96273, DOI: 10.1128/IAI.67.1.30-35.1999.
- Reactivity of human sera to different strains of granulocytic ehrlichiae in immunodiagnostic assays.Magnarelli LA, IJdo JW, Dumler JS, Heimer R, Fikrig E. Reactivity of human sera to different strains of granulocytic ehrlichiae in immunodiagnostic assays. The Journal Of Infectious Diseases 1998, 178: 1835-8. PMID: 9815246, DOI: 10.1086/314516.
- Anguita J, Rincón M, Samanta S, Barthold SW, Flavell RA, Fikrig E. Borrelia burgdorferi-infected, interleukin-6-deficient mice have decreased Th2 responses and increased lyme arthritis. The Journal Of Infectious Diseases 1998, 178: 1512-5. PMID: 9780277, DOI: 10.1086/314448.
- Magnarelli LA, Ijdo JW, Anderson JF, Padula SJ, Flavell RA, Fikrig E. Human exposure to a granulocytic Ehrlichia and other tick-borne agents in Connecticut. Journal Of Clinical Microbiology 1998, 36: 2823-7. PMID: 9738027, PMCID: PMC105071, DOI: 10.1128/JCM.36.10.2823-2827.1998.
- Fikrig E, Feng W, Aversa J, Schoen RT, Flavell RA. Differential expression of Borrelia burgdorferi genes during erythema migrans and Lyme arthritis. The Journal Of Infectious Diseases 1998, 178: 1198-201. PMID: 9806060, DOI: 10.1086/515684.
- Ijdo JW, Fikrig E. [Human granulocytic ehrlichiosis, a tick-borne disease]. Nederlands Tijdschrift Voor Geneeskunde 1998, 142: 1778-81. PMID: 9856144.
- Steere AC, Sikand VK, Meurice F, Parenti DL, Fikrig E, Schoen RT, Nowakowski J, Schmid CH, Laukamp S, Buscarino C, Krause DS. Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. Lyme Disease Vaccine Study Group. The New England Journal Of Medicine 1998, 339: 209-15. PMID: 9673298, DOI: 10.1056/NEJM199807233390401.
- Buitrago MI, Ijdo JW, Rinaudo P, Simon H, Copel J, Gadbaw J, Heimer R, Fikrig E, Bia FJ. Human granulocytic ehrlichiosis during pregnancy treated successfully with rifampin. Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America 1998, 27: 213-5. PMID: 9675481.
- Ijdo JW, Sun W, Zhang Y, Magnarelli LA, Fikrig E. Cloning of the gene encoding the 44-kilodalton antigen of the agent of human granulocytic ehrlichiosis and characterization of the humoral response. Infection And Immunity 1998, 66: 3264-9. PMID: 9632594, PMCID: PMC108341, DOI: 10.1128/IAI.66.7.3264-3269.1998.
- Nazario S, Das S, de Silva AM, Deponte K, Marcantonio N, Anderson JF, Fish D, Fikrig E, Kantor FS. Prevention of Borrelia burgdorferi transmission in guinea pigs by tick immunity. The American Journal Of Tropical Medicine And Hygiene 1998, 58: 780-5. PMID: 9660463, DOI: 10.4269/ajtmh.1998.58.780.
- Webster P, IJdo JW, Chicoine LM, Fikrig E. The agent of Human Granulocytic Ehrlichiosis resides in an endosomal compartment. The Journal Of Clinical Investigation 1998, 101: 1932-41. PMID: 9576758, PMCID: PMC508780, DOI: 10.1172/JCI1544.
- Das S, Deponte K, Marcantonio NL, Ijdo JW, Hodzic E, Katavolos P, Barthold SW, Telford SR, Kantor FS, Fikrig E. Granulocytic ehrlichiosis in tick-immune guinea pigs. Infection And Immunity 1998, 66: 1803-5. PMID: 9529119, PMCID: PMC108126, DOI: 10.1128/IAI.66.4.1803-1805.1998.
- Hodzic E, Ijdo JW, Feng S, Katavolos P, Sun W, Maretzki CH, Fish D, Fikrig E, Telford SR, Barthold SW. Granulocytic ehrlichiosis in the laboratory mouse. The Journal Of Infectious Diseases 1998, 177: 737-45. PMID: 9498456, DOI: 10.1086/514236.
- de Silva AM, Fikrig E, Hodzic E, Kantor FS, Telford SR, Barthold SW. Immune evasion by tickborne and host-adapted Borrelia burgdorferi. The Journal Of Infectious Diseases 1998, 177: 395-400. PMID: 9466527, DOI: 10.1086/514200.
- Ijdo JW, Zhang Y, Anderson ML, Goldberg D, Fikrig E. Heat shock protein 70 of the agent of human granulocytic ehrlichiosis binds to Borrelia burgdorferi antibodies. Clinical And Diagnostic Laboratory Immunology 1998, 5: 118-20. PMID: 9455892, PMCID: PMC121403.
- Sun W, IJdo JW, Telford SR, Hodzic E, Zhang Y, Barthold SW, Fikrig E. Immunization against the agent of human granulocytic ehrlichiosis in a murine model. The Journal Of Clinical Investigation 1997, 100: 3014-8. PMID: 9399947, PMCID: PMC508513, DOI: 10.1172/JCI119855.
- Fikrig E, Barthold SW, Chen M, Chang CH, Flavell RA. Protective antibodies develop, and murine Lyme arthritis regresses, in the absence of MHC class II and CD4+ T cells. Journal Of Immunology (Baltimore, Md. : 1950) 1997, 159: 5682-6. PMID: 9548512.
- Bockenstedt LK, Hodzic E, Feng S, Bourrel KW, de Silva A, Montgomery RR, Fikrig E, Radolf JD, Barthold SW. Borrelia burgdorferi strain-specific Osp C-mediated immunity in mice. Infection And Immunity 1997, 65: 4661-7. PMID: 9353047, PMCID: PMC175668.
- Magnarelli LA, Ijdo JW, Anderson JF, Madigan JE, Dumler JS, Fikrig E. Antibodies to Ehrlichia equi in dogs from the northeastern United States. Journal Of The American Veterinary Medical Association 1997, 211: 1134-7. PMID: 9364226.
- Anguita J, Samanta S, Barthold SW, Fikrig E. Ablation of interleukin-12 exacerbates Lyme arthritis in SCID mice. Infection And Immunity 1997, 65: 4334-6. PMID: 9317045, PMCID: PMC175621, DOI: 10.1128/IAI.65.10.4334-4336.1997.
- IJdo JW, Zhang Y, Hodzic E, Magnarelli LA, Wilson ML, Telford SR, Barthold SW, Fikrig E. The early humoral response in human granulocytic ehrlichiosis. The Journal Of Infectious Diseases 1997, 176: 687-92. PMID: 9291316, DOI: 10.1086/514091.
- de Silva AM, Fish D, Burkot TR, Zhang Y, Fikrig E. OspA antibodies inhibit the acquisition of Borrelia burgdorferi by Ixodes ticks. Infection And Immunity 1997, 65: 3146-50. PMID: 9234767, PMCID: PMC175444, DOI: 10.1128/IAI.65.8.3146-3150.1997.
- Anguita J, Roth R, Samanta S, Gee RJ, Barthold SW, Mamula M, Fikrig E. B7-1 and B7-2 monoclonal antibodies modulate the severity of murine Lyme arthritis. Infection And Immunity 1997, 65: 3037-41. PMID: 9234751, PMCID: PMC175428, DOI: 10.1128/IAI.65.8.3037-3041.1997.
- Barthold SW, Feng S, Bockenstedt LK, Fikrig E, Feen K. Protective and arthritis-resolving activity in sera of mice infected with Borrelia burgdorferi. Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America 1997, 25 Suppl 1: S9-17. PMID: 9233658, DOI: 10.1086/516166.
- De Silva AM, Fikrig E. Borrelia burgdorferi genes selectively expressed in ticks and mammals. Parasitology Today (Personal Ed.) 1997, 13: 267-70. PMID: 15275064, DOI: 10.1016/s0169-4758(97)01074-0.
- Brunet LR, Spielman A, Fikrig E, Telford SR. Heterogeneity of Lyme disease spirochaetes within individual vector ticks. Research In Microbiology 1997, 148: 437-45. PMID: 9765822, DOI: 10.1016/s0923-2508(97)83874-0.
- Fikrig E, Barthold SW, Sun W, Feng W, Telford SR, Flavell RA. Borrelia burgdorferi P35 and P37 proteins, expressed in vivo, elicit protective immunity. Immunity 1997, 6: 531-9. PMID: 9175831, DOI: 10.1016/s1074-7613(00)80341-6.
- Fikrig E, Barthold SW, Chen M, Tao H, Ali-Salaam P, Bockenstedt LK, Flavell RA. Lyme borreliosis in transgenic mice tolerant to OspA from Borrelia burgdorferi 25015. The Journal Of Infectious Diseases 1997, 175: 1000-3. PMID: 9086169, DOI: 10.1086/513958.
- Fikrig E, Barthold SW. Lyme disease in transgenic mice expressing the Borrelia burgdorferi flagellin epitope implicated in human neuroborreliosis. FEMS Microbiology Letters 1997, 148: 137-43. PMID: 9084140, DOI: 10.1111/j.1574-6968.1997.tb10279.x.
- Das S, Barthold SW, Giles SS, Montgomery RR, Telford SR, Fikrig E. Temporal pattern of Borrelia burgdorferi p21 expression in ticks and the mammalian host. The Journal Of Clinical Investigation 1997, 99: 987-95. PMID: 9062357, PMCID: PMC507907, DOI: 10.1172/JCI119264.
- Rincón M, Anguita J, Nakamura T, Fikrig E, Flavell RA. Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells. The Journal Of Experimental Medicine 1997, 185: 461-9. PMID: 9053446, PMCID: PMC2196041, DOI: 10.1084/jem.185.3.461.
- de Silva AM, Fikrig E. Arthropod- and host-specific gene expression by Borrelia burgdorferi. The Journal Of Clinical Investigation 1997, 99: 377-9. PMID: 9022068, PMCID: PMC507808, DOI: 10.1172/JCI119169.
- Magnarelli LA, Flavell RA, Padula SJ, Anderson JF, Fikrig E. Serologic diagnosis of canine and equine borreliosis: use of recombinant antigens in enzyme-linked immunosorbent assays. Journal Of Clinical Microbiology 1997, 35: 169-73. PMID: 8968901, PMCID: PMC229532, DOI: 10.1128/jcm.35.1.169-173.1997.
- Zhang YQ, Mathiesen D, Kolbert CP, Anderson J, Schoen RT, Fikrig E, Persing DH. Borrelia burgdorferi enzyme-linked immunosorbent assay for discrimination of OspA vaccination from spirochete infection. Journal Of Clinical Microbiology 1997, 35: 233-8. PMID: 8968914, PMCID: PMC229545, DOI: 10.1128/JCM.35.1.233-238.1997.
- Bockenstedt LK, Fikrig E, Barthold SW, Flavell RA, Kantor FS. Identification of a Borrelia burgdorferi OspA T cell epitope that promotes anti-OspA IgG in mice. Journal Of Immunology (Baltimore, Md. : 1950) 1996, 157: 5496-502. PMID: 8955199.
- Das S, Shraga D, Gannon C, Lam TT, Feng S, Brunet LR, Telford SR, Barthold SW, Flavell RA, Fikrig E. Characterization of a 30-kDa Borrelia burgdorferi substrate-binding protein homologue. Research In Microbiology 1996, 147: 739-51. PMID: 9296108, DOI: 10.1016/s0923-2508(97)85121-2.
- Feng S, Das S, Barthold SW, Fikrig E. Characterization of two genes, p11 and p5, on the Borrelia burgdorferi 49-kilo base linear plasmid. Biochimica Et Biophysica Acta 1996, 1307: 270-2. PMID: 8688460, DOI: 10.1016/0167-4781(96)00076-0.
- Fikrig E, Barthold SW, Chen M, Grewal IS, Craft J, Flavell RA. Protective antibodies in murine Lyme disease arise independently of CD40 ligand. Journal Of Immunology (Baltimore, Md. : 1950) 1996, 157: 1-3. PMID: 8683101.
- Anderson JF, Flavell RA, Magnarelli LA, Barthold SW, Kantor FS, Wallich R, Persing DH, Mathiesen D, Fikrig E. Novel Borrelia burgdorferi isolates from Ixodes scapularis and Ixodes dentatus ticks feeding on humans. Journal Of Clinical Microbiology 1996, 34: 524-9. PMID: 8904407, PMCID: PMC228839, DOI: 10.1128/jcm.34.3.524-529.1996.
- Anguita J, Persing DH, Rincon M, Barthold SW, Fikrig E. Effect of anti-interleukin 12 treatment on murine lyme borreliosis. The Journal Of Clinical Investigation 1996, 97: 1028-34. PMID: 8613525, PMCID: PMC507149, DOI: 10.1172/JCI118494.
- Magnarelli LA, Fikrig E, Padula SJ, Anderson JF, Flavell RA. Use of recombinant antigens of Borrelia burgdorferi in serologic tests for diagnosis of lyme borreliosis. Journal Of Clinical Microbiology 1996, 34: 237-40. PMID: 8788993, PMCID: PMC228775, DOI: 10.1128/jcm.34.2.237-240.1996.
- Feng S, Barthold SW, Telford SR, Fikrig E. P55, an immunogenic but nonprotective 55-kilodalton Borrelia burgdorferi protein in murine Lyme disease. Infection And Immunity 1996, 64: 363-5. PMID: 8557366, PMCID: PMC173770, DOI: 10.1128/IAI.64.1.363-365.1996.
- de Silva AM, Telford SR, Brunet LR, Barthold SW, Fikrig E. Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine. The Journal Of Experimental Medicine 1996, 183: 271-5. PMID: 8551231, PMCID: PMC2192397, DOI: 10.1084/jem.183.1.271.
- Fikrig E, Liu B, Fu LL, Das S, Smallwood JI, Flavell RA, Persing DH, Schoen RT, Barthold SW, Malawista SE. An ospA frame shift, identified from DNA in Lyme arthritis synovial fluid, results in an outer surface protein A that does not bind protective antibodies. Journal Of Immunology (Baltimore, Md. : 1950) 1995, 155: 5700-4. PMID: 7499856.
- Barthold SW, Levy SA, Fikrig E, Bockenstedt LK, Smith AL. Serologic responses of dogs naturally exposed to or vaccinated against Borrelia burgdorferi infection. Journal Of The American Veterinary Medical Association 1995, 207: 1435-40. PMID: 7493871.
- Schoen RT, Meurice F, Brunet CM, Cretella S, Krause DS, Craft JE, Fikrig E. Safety and immunogenicity of an outer surface protein A vaccine in subjects with previous Lyme disease. The Journal Of Infectious Diseases 1995, 172: 1324-9. PMID: 7594671, DOI: 10.1093/infdis/172.5.1324.
- Magnarelli LA, Dumler JS, Anderson JF, Johnson RC, Fikrig E. Coexistence of antibodies to tick-borne pathogens of babesiosis, ehrlichiosis, and Lyme borreliosis in human sera. Journal Of Clinical Microbiology 1995, 33: 3054-7. PMID: 8576376, PMCID: PMC228637, DOI: 10.1128/JCM.33.11.3054-3057.1995.
- Fikrig E, Tao H, Chen M, Barthold SW, Flavell RA. Lyme borreliosis in transgenic mice tolerant to Borrelia burgdorferi OspA or B. The Journal Of Clinical Investigation 1995, 96: 1706-14. PMID: 7560061, PMCID: PMC185806, DOI: 10.1172/JCI118215.
- De Silva AM, Fikrig E. Growth and migration of Borrelia burgdorferi in Ixodes ticks during blood feeding. The American Journal Of Tropical Medicine And Hygiene 1995, 53: 397-404. PMID: 7485694, DOI: 10.4269/ajtmh.1995.53.397.
- Jwang B, Dewing P, Fikrig E, Flavell RA. The hook protein of Borrelia burgdorferi, encoded by the flgE gene, is serologically recognized in Lyme disease. Clinical And Diagnostic Laboratory Immunology 1995, 2: 609-15. PMID: 8548542, PMCID: PMC170207, DOI: 10.1128/cdli.2.5.609-615.1995.
- Feng S, Das S, Lam T, Flavell RA, Fikrig E. A 55-kilodalton antigen encoded by a gene on a Borrelia burgdorferi 49-kilobase plasmid is recognized by antibodies in sera from patients with Lyme disease. Infection And Immunity 1995, 63: 3459-66. PMID: 7642278, PMCID: PMC173477, DOI: 10.1128/iai.63.9.3459-3466.1995.
- Cretella S, Gordon S, Flavell RA, Fikrig E. Evaluation of a Lyme disease enzyme immunoassay using the 41-G fragment of flagellin. European Journal Of Clinical Microbiology & Infectious Diseases : Official Publication Of The European Society Of Clinical Microbiology 1995, 14: 609-13. PMID: 7588849, DOI: 10.1007/BF01690736.
- Magnarelli LA, Anderson JF, Flavell RA, Fikrig E. Reactivity of white-footed mouse and raccoon sera to whole cell and recombinant antigens of Borrelia burgdorferi. Journal Of Wildlife Diseases 1995, 31: 339-44. PMID: 8592354, DOI: 10.7589/0090-3558-31.3.339.
- Feng S, Barthold SW, Bockenstedt LK, Zaller DM, Fikrig E. Lyme disease in human DR4Dw4-transgenic mice. The Journal Of Infectious Diseases 1995, 172: 286-9. PMID: 7797933, DOI: 10.1093/infdis/172.1.286.
- Barthold SW, Fikrig E, Bockenstedt LK, Persing DH. Circumvention of outer surface protein A immunity by host-adapted Borrelia burgdorferi. Infection And Immunity 1995, 63: 2255-61. PMID: 7768606, PMCID: PMC173294.
- Suk K, Das S, Sun W, Jwang B, Barthold SW, Flavell RA, Fikrig E. Borrelia burgdorferi genes selectively expressed in the infected host. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 4269-73. PMID: 7753795, PMCID: PMC41925, DOI: 10.1073/pnas.92.10.4269.
- Fikrig E, Tao H, Barthold SW, Flavell RA. Selection of variant Borrelia burgdorferi isolates from mice immunized with outer surface protein A or B. Infection And Immunity 1995, 63: 1658-62. PMID: 7729870, PMCID: PMC173206, DOI: 10.1128/iai.63.5.1658-1662.1995.
- Telford SR, Kantor FS, Lobet Y, Barthold SW, Spielman A, Flavell RA, Fikrig E. Efficacy of human Lyme disease vaccine formulations in a mouse model. The Journal Of Infectious Diseases 1995, 171: 1368-70. PMID: 7751719, DOI: 10.1093/infdis/171.5.1368.
- Dunne M, al-Ramadi BK, Barthold SW, Flavell RA, Fikrig E. Oral vaccination with an attenuated Salmonella typhimurium strain expressing Borrelia burgdorferi OspA prevents murine Lyme borreliosis. Infection And Immunity 1995, 63: 1611-4. PMID: 7890431, PMCID: PMC173199, DOI: 10.1128/iai.63.4.1611-1614.1995.
- Fikrig E, Telford SR, Wallich R, Chen M, Lobet Y, Matuschka FR, Kimsey RB, Kantor FS, Barthold SW, Spielman A, Flavell RA. Vaccination against Lyme disease caused by diverse Borrelia burgdorferi. The Journal Of Experimental Medicine 1995, 181: 215-21. PMID: 7807004, PMCID: PMC2191810, DOI: 10.1084/jem.181.1.215.
- McMillen MA, Cunningham ME, Schoen R, Fikrig E. Gout in patients with systemic lupus erythematosus. British Journal Of Rheumatology 1994, 33: 595-6. PMID: 8205413, DOI: 10.1093/rheumatology/33.6.595.
- Nguyen TP, Lam TT, Barthold SW, Telford SR, Flavell RA, Fikrig E. Partial destruction of Borrelia burgdorferi within ticks that engorged on OspE- or OspF-immunized mice. Infection And Immunity 1994, 62: 2079-84. PMID: 8168973, PMCID: PMC186469, DOI: 10.1128/iai.62.5.2079-2084.1994.
- Lam TT, Nguyen TP, Fikrig E, Flavell RA. A chromosomal Borrelia burgdorferi gene encodes a 22-kilodalton lipoprotein, P22, that is serologically recognized in Lyme disease. Journal Of Clinical Microbiology 1994, 32: 876-83. PMID: 8027338, PMCID: PMC263156, DOI: 10.1128/jcm.32.4.876-883.1994.
- Fikrig E, Bockenstedt LK, Barthold SW, Chen M, Tao H, Ali-Salaam P, Telford SR, Flavell RA. Sera from patients with chronic Lyme disease protect mice from Lyme borreliosis. The Journal Of Infectious Diseases 1994, 169: 568-74. PMID: 8158028, DOI: 10.1093/infdis/169.3.568.
- Persing DH, Rutledge BJ, Rys PN, Podzorski DS, Mitchell PD, Reed KD, Liu B, Fikrig E, Malawista SE. Target imbalance: disparity of Borrelia burgdorferi genetic material in synovial fluid from Lyme arthritis patients. The Journal Of Infectious Diseases 1994, 169: 668-72. PMID: 8158048, DOI: 10.1093/infdis/169.3.668.
- Roessner K, Fikrig E, Russell JQ, Cooper SM, Flavell RA, Budd RC. Prominent T lymphocyte response to Borrelia burgdorferi from peripheral blood of unexposed donors. European Journal Of Immunology 1994, 24: 320-4. PMID: 7905415, DOI: 10.1002/eji.1830240207.
- Lam TT, Nguyen TP, Montgomery RR, Kantor FS, Fikrig E, Flavell RA. Outer surface proteins E and F of Borrelia burgdorferi, the agent of Lyme disease. Infection And Immunity 1994, 62: 290-8. PMID: 8262642, PMCID: PMC186099, DOI: 10.1128/iai.62.1.290-298.1994.
- Fikrig E, Magnarelli LA, Chen M, Anderson JF, Flavell RA. Serologic analysis of dogs, horses, and cottontail rabbits for antibodies to an antigenic flagellar epitope of Borrelia burgdorferi. Journal Of Clinical Microbiology 1993, 31: 2451-5. PMID: 7691874, PMCID: PMC265777, DOI: 10.1128/jcm.31.9.2451-2455.1993.
- Telford SR, Fikrig E, Barthold SW, Brunet LR, Spielman A, Flavell RA. Protection against antigenically variable Borrelia burgdorferi conferred by recombinant vaccines. The Journal Of Experimental Medicine 1993, 178: 755-8. PMID: 8340764, PMCID: PMC2191140, DOI: 10.1084/jem.178.2.755.
- Bockenstedt LK, Fikrig E, Barthold SW, Kantor FS, Flavell RA. Inability of truncated recombinant Osp A proteins to elicit protective immunity to Borrelia burgdorferi in mice. Journal Of Immunology (Baltimore, Md. : 1950) 1993, 151: 900-6. PMID: 8335917.
- Fikrig E, Barthold SW, Flavell RA. OspA vaccination of mice with established Borrelia burgdorferi infection alters disease but not infection. Infection And Immunity 1993, 61: 2553-7. PMID: 8500891, PMCID: PMC280883, DOI: 10.1128/iai.61.6.2553-2557.1993.
- Fikrig E, Tao H, Kantor FS, Barthold SW, Flavell RA. Evasion of protective immunity by Borrelia burgdorferi by truncation of outer surface protein B. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 4092-6. PMID: 7683420, PMCID: PMC46452, DOI: 10.1073/pnas.90.9.4092.
- de Souza MS, Smith AL, Beck DS, Terwilliger GA, Fikrig E, Barthold SW. Long-term study of cell-mediated responses to Borrelia burgdorferi in the laboratory mouse. Infection And Immunity 1993, 61: 1814-22. PMID: 8478071, PMCID: PMC280770, DOI: 10.1128/IAI.61.5.1814-1822.1993.
- Fikrig E, Kantor FS, Barthold SW, Flavell RA. Protective immunity in lyme borreliosis. Parasitology Today (Personal Ed.) 1993, 9: 129-31. PMID: 15463734, DOI: 10.1016/0169-4758(93)90176-g.
- Comstock LE, Fikrig E, Shoberg RJ, Flavell RA, Thomas DD. A monoclonal antibody to OspA inhibits association of Borrelia burgdorferi with human endothelial cells. Infection And Immunity 1993, 61: 423-31. PMID: 7678585, PMCID: PMC302746, DOI: 10.1128/iai.61.2.423-431.1993.
- Fikrig E, Berland R, Chen M, Williams S, Sigal LH, Flavell RA. Serologic response to the Borrelia burgdorferi flagellin demonstrates an epitope common to a neuroblastoma cell line. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 183-7. PMID: 7678336, PMCID: PMC45624, DOI: 10.1073/pnas.90.1.183.
- Magnarelli LA, Fikrig E, Berland R, Anderson JF, Flavell RA. Comparison of whole-cell antibodies and an antigenic flagellar epitope of Borrelia burgdorferi in serologic tests for diagnosis of Lyme borreliosis. Journal Of Clinical Microbiology 1992, 30: 3158-62. PMID: 1280650, PMCID: PMC270607, DOI: 10.1128/jcm.30.12.3158-3162.1992.
- Simon M, Milward F, Lefebvre R, Schouls L, Fikrig E, Wasmoen T, Stover K, Menefee B, Robinson J. Spirochetes: vaccines, animal models and diagnostics. Research In Microbiology 1992, 143: 641-7. PMID: 1475524.
- Fikrig E, Telford SR, Barthold SW, Kantor FS, Spielman A, Flavell RA. Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 5418-21. PMID: 1608951, PMCID: PMC49303, DOI: 10.1073/pnas.89.12.5418.
- Fikrig E, Huguenel ED, Berland R, Rahn DW, Hardin JA, Flavell RA. Serologic diagnosis of Lyme disease using recombinant outer surface proteins A and B and flagellin. The Journal Of Infectious Diseases 1992, 165: 1127-32. PMID: 1583333, DOI: 10.1093/infdis/165.6.1127.
- Fikrig E, Barthold SW, Persing DH, Sun X, Kantor FS, Flavell RA. Borrelia burgdorferi strain 25015: characterization of outer surface protein A and vaccination against infection. Journal Of Immunology (Baltimore, Md. : 1950) 1992, 148: 2256-60. PMID: 1545130.
- de Souza MS, Fikrig E, Smith AL, Flavell RA, Barthold SW. Nonspecific proliferative responses of murine lymphocytes to Borrelia burgdorferi antigens. The Journal Of Infectious Diseases 1992, 165: 471-8. PMID: 1531672, DOI: 10.1093/infdis/165.3.471.
- Fikrig E, Barthold SW, Kantor FS, Flavell RA. Long-term protection of mice from Lyme disease by vaccination with OspA. Infection And Immunity 1992, 60: 773-7. PMID: 1541551, PMCID: PMC257553, DOI: 10.1128/iai.60.3.773-777.1992.
- Fikrig E, Barthold SW, Marcantonio N, Deponte K, Kantor FS, Flavell RA. Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice. Infection And Immunity 1992, 60: 657-61. PMID: 1730500, PMCID: PMC257680, DOI: 10.1128/iai.60.2.657-661.1992.
- Fikrig E, Barthold SW, Kantor FS, Flavell RA. Protection of mice from Lyme borreliosis by oral vaccination with Escherichia coli expressing OspA. The Journal Of Infectious Diseases 1991, 164: 1224-7. PMID: 1955724, DOI: 10.1093/infdis/164.6.1224.
- Berland R, Fikrig E, Rahn D, Hardin J, Flavell RA. Molecular characterization of the humoral response to the 41-kilodalton flagellar antigen of Borrelia burgdorferi, the Lyme disease agent. Infection And Immunity 1991, 59: 3531-5. PMID: 1894359, PMCID: PMC258917, DOI: 10.1128/iai.59.10.3531-3535.1991.
- Sears JE, Fikrig E, Nakagawa TY, Deponte K, Marcantonio N, Kantor FS, Flavell RA. Molecular mapping of Osp-A mediated immunity against Borrelia burgdorferi, the agent of Lyme disease. Journal Of Immunology (Baltimore, Md. : 1950) 1991, 147: 1995-2000. PMID: 1716290.
- Fikrig E, Barthold SW, Kantor FS, Flavell RA. Protection of mice against the Lyme disease agent by immunizing with recombinant OspA. Science (New York, N.Y.) 1990, 250: 553-6. PMID: 2237407, DOI: 10.1126/science.2237407.
- Fikrig E, Barg NL. Varicella associated intracerebral hemorrhage in the absence of thrombocytopenia. Diagnostic Microbiology And Infectious Disease 1989, 12: 357-9. PMID: 2591170, DOI: 10.1016/0732-8893(89)90103-x.
- Fikrig E, Worthington MT, Lefkowitz LB. Septic shock and acute respiratory distress syndrome after salpingitis caused by Streptococcus pyogenes group A. Southern Medical Journal 1989, 82: 634-5. PMID: 2655106, DOI: 10.1097/00007611-198905000-00024.
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