- Yale Dermatologic SurgeryTemple Medical Center40 Temple Street, Ste 5th Floor, Suite 5ANew Haven, CT 06510
David Leffell, MD, MHS, AuD
Biography
rumson David J. Leffell, MD, is an internationally recognized expert in skin health and the founder and chief of the Dermatologic Surgery Program at Yale Medicine. The program, which began in 1988, is a national leader, combining the highest level of patient-focused care with ongoing research into the causes of skin cancer and melanoma.
“I was privileged to be able to pursue my vision of providing exceptional patient care, research and training,” says Dr. Leffell.
Dr. Leffell has treated over 35,000 skin cancer and melanoma patients in his 30-year career. By specializing in the diagnosis, treatment and prevention of skin cancer, melanoma and rare skin tumors, he has developed a unique expertise which he has been able to share with generations of future doctors.
Dr. Leffell, a professor of dermatology, plastic surgery and otolaryngology at Yale School of Medicine, derives great satisfaction from the daily opportunity to pass on his knowledge and skill to fellows and other doctors in training. He emphasizes the importance of communication in the doctor-patient relationship. “Everything central to being a doctor flows from that: compassion, understanding, and effectiveness as a healer,” he says.
An internationally known researcher in the field of skin cancer, Dr. Leffell was involved with the discovery of the gene (PTCH) for the most common form of skin cancer, called basal cell cancer.
He has collaborated in research focused on understanding skin cancer in young women. Important new research into why women are developing skin cancer more often than expected was triggered following Dr. Leffell’s observation of the phenomenon. He holds three patents, including one for a laser device which measures aging of skin.
In addition to his clinical and research work, Dr. Leffell has published over 170 papers and has been an editor of the world’s leading textbook of dermatology, Fitzpatrick’s Dermatology in General Medicine. He is the author of Manual of Skin Surgery and Total Skin: The Definitive Guide to Whole Skin Care for Life.
Beauty and creativity also inform his personal life. In his spare time, Dr. Leffell builds furniture from locally harvested wood, and is an avid photographer. He recently published a collection of photographs of northwest Connecticut titled Connecticut Pastoral.
“Art, scientific research and clinical diagnosis—at the microscope or with the patient—all have in common the fundamental element of seeing or extracting a pattern. Once you can see the pattern, you can understand,” says Dr. Leffell.
Titles
- David P. Smith Professor of Dermatology and Professor of Surgery (Otolaryngology and Plastic)
- Section Chief, Dermatologic Surgery and Cutaneous Oncology, Acute Interventions for Stroke
- set end date, 1st Year Fellows
Education & Training
- MHSs, s (2023)
- AuDintitution , dept (2023)
- FellowUniversity of Michigan Medical School, Ann Arbor, MI (1988)
- N.I.H Postdoctoral FellowYale University School of Medicine, New Haven, CT (1987)
- ResidentYale-New Haven Hospital, New Haven, CT (1986)
- ResidentCornell Cooperating Hospitals (1984)
- InternCornell Cooperating Hospitals (1982)
- MDMcGill University (1981)
- BSYale College, Biology (1977)
Languages Spoken
- English
- Français (French)
Additional Information
- award : org (2023)
- award: org (2023)
- award : org (2023), (2023), (2023)
- tretret: ertertret (2023)
- award: org (2023)
- Connecticut Magazine Top Docs 2016: Connecticut Magazine (2019)
- Best Doctors in New York: Castle and Connolly (2016)
- Best Doctors in America: Castle & Connolly (2014), (2015), (2016), (2017), (2018), (2019), (2020), (2020), (2022), (2023)
- Best Cancer Doctors in America: (2010), (2011), (2012), (2012), (2013), (2014), (2015), (2016), (2017), (2018)
- AB of Dermatology, Dermatology (1987, recertified: 2009)
- AB of Internal Medicine, Internal Medicine (1984)
- mewdia presence (2022): Treasurer
- Society for Investigative Dermatology, Committee on Resident/ Fellow Programs (2004 - 2008)
- Women's Dermatologic Society, Networking Committee (1998 - 2001)
- Women's Dermatologic Society, Mentorship Award Committee (1998 - 2001)
- prof orgs (1959 - 2031): test
- Beltrami EJ, Brown AC, Salmon PJM, Leffell DJ, Ko JM, Grant-Kels JM. Artificial Intelligence in the Detection of Skin Cancer. Journal Of The American Academy Of Dermatology 2022 PMID: 35998842, DOI: 10.1016/j.jaad.2022.08.028.
- Prassinos A, Glusac E, Leffell DJ. Melanoma in situ: Don't make the cure worse than the disease. Journal Of The American Academy Of Dermatology 2021, 85: 520. PMID: 32387662, DOI: 10.1016/j.jaad.2020.04.168.
- Kibbi N, Khan Y, Leffell DJ, Christensen SR, Suozzi KC. Predicting outcomes following second intent healing of periocular surgical defects. Archives Of Dermatological Research 2021, 313: 483-489. PMID: 32833078, DOI: 10.1007/s00403-020-02122-w.
- Kibbi N, Zhang Y, Leffell DJ, Christensen SR. Photodynamic therapy for cutaneous squamous cell carcinoma in situ: Impact of anatomic location, tumor diameter, and incubation time on effectiveness. Journal Of The American Academy Of Dermatology 2020, 82: 1124-1130. PMID: 31712171, DOI: 10.1016/j.jaad.2019.10.079.
- Rodriguez-Diaz E, Manolakos D, Christman H, Bonning MA, Geisse JK, A'Amar OM, Leffell DJ, Bigio IJ. Optical Spectroscopy as a Method for Skin Cancer Risk Assessment. Photochemistry And Photobiology 2019, 95: 1441-1445. PMID: 31287160, DOI: 10.1111/php.13140.
- Kibbi N, Suozzi KC, Ko CJ, Leffell DJ. Squamous Cell Carcinoma of the Lip in a Patient With Graft-Versus-Host Disease. Dermatologic Surgery : Official Publication For American Society For Dermatologic Surgery [et Al.] 2019, 45: 1002-1005. PMID: 31260417, DOI: 10.1097/DSS.0000000000001706.
- Ko CJ, Myung P, Leffell DJ, Bourdon JC. Cutaneous immunohistochemical staining pattern of p53β isoforms. Journal Of Clinical Pathology 2018, 71: 1120-1122. PMID: 30305316, DOI: 10.1136/jclinpath-2018-205098.
- Totonchy MB, Leventhal JS, Ko CJ, Leffell DJ. Hypertrophic Lichen Planus and Well-Differentiated Squamous Cell Carcinoma: A Diagnostic Conundrum. Dermatologic Surgery : Official Publication For American Society For Dermatologic Surgery [et Al.] 2018, 44: 1466-1470. PMID: 29360655, DOI: 10.1097/DSS.0000000000001465.
- Ferrucci LM, Cartmel B, Clare RA, Choy CC, Kershaw T, Leffell DJ, Mayne ST. Cross-sectional assessment of ultraviolet radiation-related behaviors among young people after a diagnosis of melanoma or basal cell carcinoma. Journal Of The American Academy Of Dermatology 2018, 79: 149-152. PMID: 29291957, PMCID: PMC6004335, DOI: 10.1016/j.jaad.2017.12.056.
- Ezaldein HH, Scott JF, Yin ES, Ventura A, DeRuyter NP, Leffell DJ. Transparency and Dermatologic Device Approval by the US Food and Drug Administration. JAMA Dermatology 2018, 154: 273-280. PMID: 29365020, PMCID: PMC5885836, DOI: 10.1001/jamadermatol.2017.5757.
- Ko CJ, Glusac EJ, McNiff JM, Rodic N, Leffell DJ. Squamous proliferations on the legs of women: Qualitative examination of histopathology, TP53 sequencing, and implications for diagnosis in a series of 30 cases. Journal Of The American Academy Of Dermatology 2017, 77: 1126-1132.e1. PMID: 28709693, DOI: 10.1016/j.jaad.2017.04.1119.
- Cartmel B, Bale AE, Mayne ST, Gelernter JE, DeWan AT, Spain P, Leffell DJ, Pagoto S, Ferrucci LM. Predictors of tanning dependence in white non-Hispanic females and males. Journal Of The European Academy Of Dermatology And Venereology : JEADV 2017, 31: 1223-1228. PMID: 28129487, PMCID: PMC5522341, DOI: 10.1111/jdv.14138.
- Panse G, Cowper SE, Leffell DJ, Pulitzer M, Ko CJ. Well-differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63. Journal Of Cutaneous Pathology 2017, 44: 557-562. PMID: 28417484, DOI: 10.1111/cup.12952.
- Zhang Y, Cartmel B, Choy CC, Molinaro AM, Leffell DJ, Bale AE, Mayne ST, Ferrucci LM. Body mass index, height and early-onset basal cell carcinoma in a case-control study. Cancer Epidemiology 2017, 46: 66-72. PMID: 28039770, PMCID: PMC5272867, DOI: 10.1016/j.canep.2016.12.007.
- Totonchy M, Leffell D. Emerging concepts and recent advances in basal cell carcinoma. F1000Research 2017, 6: 2085. PMID: 29259776, PMCID: PMC5717469, DOI: 10.12688/f1000research.11314.1.
- Munday WR, Leffell DJ, McNiff JM, Ko CJ. Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity. Journal Of Cutaneous Pathology 2016, 43: 759-65. PMID: 27220356, DOI: 10.1111/cup.12738.
- Christensen SR, McNiff JM, Cool AJ, Aasi SZ, Hanlon AM, Leffell DJ. Histopathologic assessment of depth of follicular invasion of squamous cell carcinoma (SCC) in situ (SCCis): Implications for treatment approach. Journal Of The American Academy Of Dermatology 2016, 74: 356-62. PMID: 26670714, DOI: 10.1016/j.jaad.2015.09.060.
- Berlin NL, Cartmel B, Leffell DJ, Bale AE, Mayne ST, Ferrucci LM. Family history of skin cancer is associated with early-onset basal cell carcinoma independent of MC1R genotype. Cancer Epidemiology 2015, 39: 1078-83. PMID: 26381319, PMCID: PMC4679454, DOI: 10.1016/j.canep.2015.09.005.
- Izikson R, Leffell DJ, Bock SA, Patriarca PA, Post P, Dunkle LM, Cox MM. Randomized comparison of the safety of Flublok(®) versus licensed inactivated influenza vaccine in healthy, medically stable adults ≥ 50 years of age. Vaccine 2015, 33: 6622-8. PMID: 26529070, DOI: 10.1016/j.vaccine.2015.10.097.
- Higgins HW, Lee KC, Galan A, Leffell DJ. Melanoma in situ: Part I. Epidemiology, screening, and clinical features. Journal Of The American Academy Of Dermatology 2015, 73: 181-90, quiz 191-2. PMID: 26183967, DOI: 10.1016/j.jaad.2015.04.014.
- Berlin NL, Ferrucci LM, Cartmel B, Wang SY, Leffell DJ, McNiff JM, Mayne ST. Subsequent skin cancer in patients with early-onset basal cell carcinoma. The Australasian Journal Of Dermatology 2015, 56: 236-7. PMID: 26201376, DOI: 10.1111/ajd.12338.
- Higgins HW, Lee KC, Galan A, Leffell DJ. Melanoma in situ: Part II. Histopathology, treatment, and clinical management. Journal Of The American Academy Of Dermatology 2015, 73: 193-203; quiz 203-4. PMID: 26183968, DOI: 10.1016/j.jaad.2015.03.057.
- Indoor tanning and the MC1R genotype: risk prediction for basal cell carcinoma risk in young people.Molinaro AM, Ferrucci LM, Cartmel B, Loftfield E, Leffell DJ, Bale AE, Mayne ST. Indoor tanning and the MC1R genotype: risk prediction for basal cell carcinoma risk in young people. American Journal Of Epidemiology 2015, 181: 908-16. PMID: 25858289, PMCID: PMC4445390, DOI: 10.1093/aje/kwu356.
- Mendez JJ, Ghaedi M, Sivarapatna A, Dimitrievska S, Shao Z, Osuji CO, Steinbacher DM, Leffell DJ, Niklason LE. Mesenchymal stromal cells form vascular tubes when placed in fibrin sealant and accelerate wound healing in vivo. Biomaterials 2015, 40: 61-71. PMID: 25433608, PMCID: PMC4268422, DOI: 10.1016/j.biomaterials.2014.11.011.
- Kim J, Singh Maan H, Cool AJ, Hanlon AM, Leffell DJ. Fast Absorbing Gut Suture versus Cyanoacrylate Tissue Adhesive in the Epidermal Closure of Linear Repairs Following Mohs Micrographic Surgery. The Journal Of Clinical And Aesthetic Dermatology 2015, 8: 24-9. PMID: 25741400, PMCID: PMC4345930.
- Goldberg C, Hoang D, McRae M, Chung C, Leffell DJ, Narayan D. A strategy for the successful management of dermatofibrosarcoma protuberans. Annals Of Plastic Surgery 2015, 74: 80-4. PMID: 23788146, DOI: 10.1097/SAP.0b013e3182898692.
- Zhang Y, Ferrucci LM, Cartmel B, Molinaro AM, Leffell DJ, Bale AE, Mayne ST. Alcohol intake and early-onset basal cell carcinoma in a case-control study. The British Journal Of Dermatology 2014, 171: 1451-7. PMID: 25059635, PMCID: PMC4272627, DOI: 10.1111/bjd.13291.
- Cartmel B, Dewan A, Ferrucci LM, Gelernter J, Stapleton J, Leffell DJ, Mayne ST, Bale AE. Novel gene identified in an exome-wide association study of tanning dependence. Experimental Dermatology 2014, 23: 757-9. PMID: 25041255, PMCID: PMC4204712, DOI: 10.1111/exd.12503.
- Troche JR, Ferrucci LM, Cartmel B, Leffell DJ, Bale AE, Mayne ST. Systemic glucocorticoid use and early-onset basal cell carcinoma. Annals Of Epidemiology 2014, 24: 625-7. PMID: 24958637, PMCID: PMC4119504, DOI: 10.1016/j.annepidem.2014.05.009.
- Ferrucci LM, Cartmel B, Molinaro AM, Leffell DJ, Bale AE, Mayne ST. Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case-control study. European Journal Of Cancer Prevention : The Official Journal Of The European Cancer Prevention Organisation (ECP) 2014, 23: 296-302. PMID: 24841641, PMCID: PMC4059399, DOI: 10.1097/CEJ.0000000000000037.
- Kim C, Ko CJ, Leffell DJ. Cutaneous squamous cell carcinomas of the lower extremity: a distinct subset of squamous cell carcinomas. Journal Of The American Academy Of Dermatology 2014, 70: 70-4. PMID: 24210370, DOI: 10.1016/j.jaad.2013.09.026.
- Higgins HW, Lee KC, Leffell DJ. Point of care cutaneous imaging technology in melanoma screening and mole mapping. F1000prime Reports 2014, 6: 34. PMID: 24860656, PMCID: PMC4017910, DOI: 10.12703/P6-34.
- Hanlon A, Kim J, Leffell DJ. Intralesional interferon alfa-2b for refractory, recurrent squamous cell carcinoma of the face. Journal Of The American Academy Of Dermatology 2013, 69: 1070-2. PMID: 24238178, DOI: 10.1016/j.jaad.2013.02.032.
- Scarmo S, Cartmel B, Lin H, Leffell DJ, Ermakov IV, Gellermann W, Bernstein PS, Mayne ST. Single v. multiple measures of skin carotenoids by resonance Raman spectroscopy as a biomarker of usual carotenoid status. The British Journal Of Nutrition 2013, 110: 911-7. PMID: 23351238, PMCID: PMC3696054, DOI: 10.1017/S000711451200582X.
- Cartmel B, Ferrucci LM, Spain P, Bale AE, Pagoto SL, Leffell DJ, Gelernter J, Mayne ST. Indoor tanning and tanning dependence in young people after a diagnosis of basal cell carcinoma. JAMA Dermatology 2013, 149: 1110-1. PMID: 23824273, PMCID: PMC3782995, DOI: 10.1001/jamadermatol.2013.5104.
- Bunick CG, Leffell D, Bosenberg M, Yahalom J, Choi JN. Cutaneous Rosai-Dorfman disease of the right ear responsive to radiotherapy. Journal Of The American Academy Of Dermatology 2012, 67: e225-6. PMID: 23062927, DOI: 10.1016/j.jaad.2012.04.025.
- Ferrucci LM, Cartmel B, Molinaro AM, Leffell DJ, Bale AE, Mayne ST. Indoor tanning and risk of early-onset basal cell carcinoma. Journal Of The American Academy Of Dermatology 2012, 67: 552-62. PMID: 22153793, PMCID: PMC3307842, DOI: 10.1016/j.jaad.2011.11.940.
- Ferrucci LM, Cartmel B, Molinaro AM, Gordon PB, Leffell DJ, Bale AE, Mayne ST. Host phenotype characteristics and MC1R in relation to early-onset basal cell carcinoma. The Journal Of Investigative Dermatology 2012, 132: 1272-9. PMID: 22158557, PMCID: PMC3305835, DOI: 10.1038/jid.2011.402.
- Jedrych J, Leffell D, McNiff JM. Desmoplastic trichoepithelioma with perineural involvement: a series of seven cases. Journal Of Cutaneous Pathology 2012, 39: 317-23. PMID: 22335590, DOI: 10.1111/j.1600-0560.2012.01876.x.
- Lostritto K, Ferrucci LM, Cartmel B, Leffell DJ, Molinaro AM, Bale AE, Mayne ST. Lifetime history of indoor tanning in young people: a retrospective assessment of initiation, persistence, and correlates. BMC Public Health 2012, 12: 118. PMID: 22324969, PMCID: PMC3340300, DOI: 10.1186/1471-2458-12-118.
- Heffelfinger C, Ouyang Z, Engberg A, Leffell DJ, Hanlon AM, Gordon PB, Zheng W, Zhao H, Snyder MP, Bale AE. Correlation of Global MicroRNA Expression With Basal Cell Carcinoma Subtype. G3 (Bethesda, Md.) 2012, 2: 279-86. PMID: 22384406, PMCID: PMC3284335, DOI: 10.1534/g3.111.001115.
- Choi JN, Hanlon A, Leffell D. Melanoma and nevi: detection and diagnosis. Current Problems In Cancer 2011, 35: 138-61. PMID: 21911179, DOI: 10.1016/j.currproblcancer.2011.07.005.
- Scarmo S, Cartmel B, Lin H, Leffell DJ, Welch E, Bhosale P, Bernstein PS, Mayne ST. Significant correlations of dermal total carotenoids and dermal lycopene with their respective plasma levels in healthy adults. Archives Of Biochemistry And Biophysics 2010, 504: 34-9. PMID: 20637178, PMCID: PMC2957565, DOI: 10.1016/j.abb.2010.07.004.
- Mayne ST, Cartmel B, Scarmo S, Lin H, Leffell DJ, Welch E, Ermakov I, Bhosale P, Bernstein PS, Gellermann W. Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake. The American Journal Of Clinical Nutrition 2010, 92: 794-800. PMID: 20685953, PMCID: PMC3133234, DOI: 10.3945/ajcn.2010.29707.
- Terushkin E, Leffell DJ, Futoryan T, Cowper S, Lazova R. Squamoid eccrine ductal carcinoma: a case report and review of the literature. The American Journal Of Dermatopathology 2010, 32: 287-292. PMID: 20010402, DOI: 10.1097/DAD.0b013e3181b623c4.
- Ko CJ, Leffell DJ, McNiff JM. Adenosquamous carcinoma: a report of nine cases with p63 and cytokeratin 5/6 staining. Journal Of Cutaneous Pathology 2009, 36: 448-52. PMID: 19278431, DOI: 10.1111/j.1600-0560.2008.01083.x.
- Mariwalla K, Aasi SZ, Glusac EJ, Leffell DJ. Mohs micrographic surgery histopathology concordance. Journal Of The American Academy Of Dermatology 2009, 60: 94-8. PMID: 19103361, PMCID: PMC2632938, DOI: 10.1016/j.jaad.2008.09.061.
- Neville JA, Welch E, Leffell DJ. Management of nonmelanoma skin cancer in 2007. Nature Clinical Practice. Oncology 2007, 4: 462-9. PMID: 17657251, DOI: 10.1038/ncponc0883.
- Newman JC, Leffell DJ. Correlation of embryonic fusion planes with the anatomical distribution of basal cell carcinoma. Dermatologic Surgery : Official Publication For American Society For Dermatologic Surgery [et Al.] 2007, 33: 957-64; discussion 965. PMID: 17661939, DOI: 10.1111/j.1524-4725.2007.33198.x.
- Bhattacharjee P, Leffell D, McNiff JM. Primary cutaneous carcinosarcoma arising in a patient with nevoid basal cell carcinoma syndrome. Journal Of Cutaneous Pathology 2005, 32: 638-41. PMID: 16176303, DOI: 10.1111/j.0303-6987.2005.00384.x.
- Pennington BE, Leffell DJ. Mohs micrographic surgery: established uses and emerging trends. Oncology (Williston Park, N.Y.) 2005, 19: 1165-71; discussion 1171-2, 1175. PMID: 16255133.
- Asplund A, Gustafsson AC, Wikonkal NM, Sela A, Leffell DJ, Kidd K, Lundeberg J, Brash DE, Pontén F. PTCH codon 1315 polymorphism and risk for nonmelanoma skin cancer. The British Journal Of Dermatology 2005, 152: 868-73. PMID: 15888139, DOI: 10.1111/j.1365-2133.2005.06464.x.
- Aasi SZ, Leffell DJ. Bilobed transposition flap. Dermatologic Clinics 2005, 23: 55-64, vi. PMID: 15620619, DOI: 10.1016/j.det.2004.08.004.
- Aasi SZ, Leffell DJ. Complications in dermatologic surgery: how safe is safe? Archives Of Dermatology 2003, 139: 213-4. PMID: 12588228, DOI: 10.1001/archderm.139.2.213.
- Leffell DJ. Clinical efficacy of devices for nonablative photorejuvenation. Archives Of Dermatology 2002, 138: 1503-8. PMID: 12437458, DOI: 10.1001/archderm.138.11.1503.
- Olhoffer IH, Lazova R, Leffell DJ. Histopathologic misdiagnoses and their clinical consequences. Archives Of Dermatology 2002, 138: 1381-3. PMID: 12374557, DOI: 10.1001/archderm.138.10.1381.
- Carucci JA, Kolenik SA, Leffell DJ. Human cadaveric allograft for repair of nasal defects after extirpation of Basal cell carcinoma by Mohs micrographic surgery. Dermatologic Surgery : Official Publication For American Society For Dermatologic Surgery [et Al.] 2002, 28: 340-3. PMID: 11966793, DOI: 10.1046/j.1524-4725.2002.01143.x.
- Carucci JA, Kolenik SA, Leffell DJ. Repair of a defect of the lower lip. Dermatologic Surgery : Official Publication For American Society For Dermatologic Surgery [et Al.] 2002, 28: 195-6. PMID: 11860438, DOI: 10.1046/j.1524-4725.2002.01250.x.
- Chen T, Yan W, Wells RG, Rimm DL, McNiff J, Leffell D, Reiss M. Novel inactivating mutations of transforming growth factor-beta type I receptor gene in head-and-neck cancer metastases. International Journal Of Cancer. Journal International Du Cancer 2001, 93: 653-61. PMID: 11477574, DOI: 10.1002/ijc.1381.
- Alexey TestSome citation
- Leffell DJ, Arndt KA. The dermatologic surgery issue: A new face for the ARCHIVES Archives Of Dermatology 2000, 136: 1404. PMID: 11074706, DOI: 10.1001/archderm.136.11.1404.
- Hahn H, Wicking C, Zaphiropoulous PG, Gailani MR, Shanley S, Chidambaram A, Vorechovsky I, Holmberg E, Unden AB, Gillies S, Negus K, Smyth I, Pressman C, Leffell DJ, Gerrard B, Goldstein AM, Dean M, Toftgard R, Chenevix-Trench G, Wainwright B, Bale AE. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 1996, 85: 841-51. PMID: 8681379.
- Ziegler A, Jonason A, Simon J, Leffell D, Brash DE. Tumor suppressor gene mutations and photocarcinogenesis. Photochemistry And Photobiology 1996, 63: 432-5. PMID: 8934758.
- Gailani MR, Leffell DJ, Ziegler A, Gross EG, Brash DE, Bale AE. Relationship between sunlight exposure and a key genetic alteration in basal cell carcinoma. Journal Of The National Cancer Institute 1996, 88: 349-54. PMID: 8609643.
- Ziegler A, Jonason AS, Leffell DJ, Simon JA, Sharma HW, Kimmelman J, Remington L, Jacks T, Brash DE. Sunburn and p53 in the onset of skin cancer. Nature 1994, 372: 773-6. PMID: 7997263, DOI: 10.1038/372773a0.
- Ziegler A, Leffell DJ, Kunala S, Sharma HW, Gailani M, Simon JA, Halperin AJ, Baden HP, Shapiro PE, Bale AE. Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 4216-20. PMID: 8483937, PMCID: PMC46477.
- Leffell DJ, Headington JT, Wong DS, Swanson NA. Aggressive-growth basal cell carcinoma in young adults. Archives Of Dermatology 1991, 127: 1663-7. PMID: 1952969.
- Leffell DJ, Stetz ML, Milstone LM, Deckelbaum LI. In vivo fluorescence of human skin. A potential marker of photoaging. Archives Of Dermatology 1988, 124: 1514-8. PMID: 3421727.
- Dillon JG, Wade CW, Daly WH. Enzyme immobilization on fibrin. Biotechnol Bioeng 1976, 18: 133-9. PMID: 2354, DOI: 10.1002/bit.260180112.
- Goss DJ, Parkhurst LJ, Görisch H. Kinetic light scattering studies on the dissociation of hemoglobin from Lumbricus terrestris. Biochemistry 1975, 14: 5461-4. PMID: 56, DOI: 10.1021/bi00696a012.
- Kaizu T, Margolius HS. Studies on rat renal cortical cell kallikrein. I. Separation and measurement. Biochim Biophys Acta 1975, 411: 305-15. PMID: 78, DOI: 10.1016/0304-4165(75)90310-4.
- McPhie P. The origin of the alkaline inactivation of pepsinogen. Biochemistry 1975, 14: 5253-6. PMID: 44, DOI: 10.1021/bi00695a003.
- Hattori M, Frazier J, Miles HT. Poly(8-aminoguanylic acid): formation of ordered self-structures and interaction with poly(cytidylic acid). Biochemistry 1975, 14: 5033-45. PMID: 37, DOI: 10.1021/bi00694a002.
- Garner CW, Behal FJ. Effect of pH on substrate and inhibitor kinetic constants of human liver alanine aminopeptidase. Evidence for two ionizable active center groups. Biochemistry 1975, 14: 5084-8. PMID: 38, DOI: 10.1021/bi00694a009.
- Sanner T. Formation of transient complexes in the glutamate dehydrogenase catalyzed reaction. Biochemistry 1975, 14: 5094-8. PMID: 39, DOI: 10.1021/bi00694a011.
- Stellwagen E, Babul J. Stabilization of the globular structure of ferricytochrome c by chloride in acidic solvents. Biochemistry 1975, 14: 5135-40. PMID: 41, DOI: 10.1021/bi00694a018.
- Orskov ER, Fraser C. The effects of processing of barley-based supplements on rumen pH, rate of digestion of voluntary intake of dried grass in sheep. Br J Nutr 1975, 34: 493-500. PMID: 36, DOI: 10.1017/s0007114575000530.
- Christensen H, Felby S. Dibenzepine and its metabolites in blood, muscle, liver, vitreous body and urine from fatal poisoning. Acta Pharmacol Toxicol (Copenh) 1975, 37: 393-401. PMID: 888, DOI: 10.1111/j.1600-0773.1975.tb00858.x.
- Abraham KA, Eikhom TS. Determination of polyadenylate-rich ribonucleic acid in the nucleus and in the cytoplasm of plasmacytoma cells. Biochem J 1975, 149: 669-74. PMID: 999, DOI: 10.1042/bj1490669.
- Runcan V, Oproiu A, State I, Vlădăreanu S. [Prolonged treatment with prednisone and azathioprine in chronic hepatitis with immunological disorders]. Rev Med Interna Neurol Psihiatr Neurochir Dermatovenerol Med Interna 1975, 27: 273-7. PMID: 777.
- Worathumrong N, Grimes AJ. The effect of o-salicylate upon pentose phosphate pathway activity in normal and G6PD-deficient red cells. Br J Haematol 1975, 30: 225-31. PMID: 35, DOI: 10.1111/j.1365-2141.1975.tb00536.x.
- . Gastroduodenal emptying and motility. Scand J Gastroenterol Suppl 1975, 35: 1-87. PMID: 787.
Biography
rumson David J. Leffell, MD, is an internationally recognized expert in skin health and the founder and chief of the Dermatologic Surgery Program at Yale Medicine. The program, which began in 1988, is a national leader, combining the highest level of patient-focused care with ongoing research into the causes of skin cancer and melanoma.
“I was privileged to be able to pursue my vision of providing exceptional patient care, research and training,” says Dr. Leffell.
Dr. Leffell has treated over 35,000 skin cancer and melanoma patients in his 30-year career. By specializing in the diagnosis, treatment and prevention of skin cancer, melanoma and rare skin tumors, he has developed a unique expertise which he has been able to share with generations of future doctors.
Dr. Leffell, a professor of dermatology, plastic surgery and otolaryngology at Yale School of Medicine, derives great satisfaction from the daily opportunity to pass on his knowledge and skill to fellows and other doctors in training. He emphasizes the importance of communication in the doctor-patient relationship. “Everything central to being a doctor flows from that: compassion, understanding, and effectiveness as a healer,” he says.
An internationally known researcher in the field of skin cancer, Dr. Leffell was involved with the discovery of the gene (PTCH) for the most common form of skin cancer, called basal cell cancer.
He has collaborated in research focused on understanding skin cancer in young women. Important new research into why women are developing skin cancer more often than expected was triggered following Dr. Leffell’s observation of the phenomenon. He holds three patents, including one for a laser device which measures aging of skin.
In addition to his clinical and research work, Dr. Leffell has published over 170 papers and has been an editor of the world’s leading textbook of dermatology, Fitzpatrick’s Dermatology in General Medicine. He is the author of Manual of Skin Surgery and Total Skin: The Definitive Guide to Whole Skin Care for Life.
Beauty and creativity also inform his personal life. In his spare time, Dr. Leffell builds furniture from locally harvested wood, and is an avid photographer. He recently published a collection of photographs of northwest Connecticut titled Connecticut Pastoral.
“Art, scientific research and clinical diagnosis—at the microscope or with the patient—all have in common the fundamental element of seeing or extracting a pattern. Once you can see the pattern, you can understand,” says Dr. Leffell.
Titles
- David P. Smith Professor of Dermatology and Professor of Surgery (Otolaryngology and Plastic)
- Section Chief, Dermatologic Surgery and Cutaneous Oncology, Acute Interventions for Stroke
- set end date, 1st Year Fellows
Education & Training
- MHSs, s (2023)
- AuDintitution , dept (2023)
- FellowUniversity of Michigan Medical School, Ann Arbor, MI (1988)
- N.I.H Postdoctoral FellowYale University School of Medicine, New Haven, CT (1987)
- ResidentYale-New Haven Hospital, New Haven, CT (1986)
- ResidentCornell Cooperating Hospitals (1984)
- InternCornell Cooperating Hospitals (1982)
- MDMcGill University (1981)
- BSYale College, Biology (1977)
Languages Spoken
- English
- Français (French)
Additional Information
- award : org (2023)
- award: org (2023)
- award : org (2023), (2023), (2023)
- tretret: ertertret (2023)
- award: org (2023)
- Connecticut Magazine Top Docs 2016: Connecticut Magazine (2019)
- Best Doctors in New York: Castle and Connolly (2016)
- Best Doctors in America: Castle & Connolly (2014), (2015), (2016), (2017), (2018), (2019), (2020), (2020), (2022), (2023)
- Best Cancer Doctors in America: (2010), (2011), (2012), (2012), (2013), (2014), (2015), (2016), (2017), (2018)
- AB of Dermatology, Dermatology (1987, recertified: 2009)
- AB of Internal Medicine, Internal Medicine (1984)
- mewdia presence (2022): Treasurer
- Society for Investigative Dermatology, Committee on Resident/ Fellow Programs (2004 - 2008)
- Women's Dermatologic Society, Networking Committee (1998 - 2001)
- Women's Dermatologic Society, Mentorship Award Committee (1998 - 2001)
- prof orgs (1959 - 2031): test
- Beltrami EJ, Brown AC, Salmon PJM, Leffell DJ, Ko JM, Grant-Kels JM. Artificial Intelligence in the Detection of Skin Cancer. Journal Of The American Academy Of Dermatology 2022 PMID: 35998842, DOI: 10.1016/j.jaad.2022.08.028.
- Prassinos A, Glusac E, Leffell DJ. Melanoma in situ: Don't make the cure worse than the disease. Journal Of The American Academy Of Dermatology 2021, 85: 520. PMID: 32387662, DOI: 10.1016/j.jaad.2020.04.168.
- Kibbi N, Khan Y, Leffell DJ, Christensen SR, Suozzi KC. Predicting outcomes following second intent healing of periocular surgical defects. Archives Of Dermatological Research 2021, 313: 483-489. PMID: 32833078, DOI: 10.1007/s00403-020-02122-w.
- Kibbi N, Zhang Y, Leffell DJ, Christensen SR. Photodynamic therapy for cutaneous squamous cell carcinoma in situ: Impact of anatomic location, tumor diameter, and incubation time on effectiveness. Journal Of The American Academy Of Dermatology 2020, 82: 1124-1130. PMID: 31712171, DOI: 10.1016/j.jaad.2019.10.079.
- Rodriguez-Diaz E, Manolakos D, Christman H, Bonning MA, Geisse JK, A'Amar OM, Leffell DJ, Bigio IJ. Optical Spectroscopy as a Method for Skin Cancer Risk Assessment. Photochemistry And Photobiology 2019, 95: 1441-1445. PMID: 31287160, DOI: 10.1111/php.13140.
- Kibbi N, Suozzi KC, Ko CJ, Leffell DJ. Squamous Cell Carcinoma of the Lip in a Patient With Graft-Versus-Host Disease. Dermatologic Surgery : Official Publication For American Society For Dermatologic Surgery [et Al.] 2019, 45: 1002-1005. PMID: 31260417, DOI: 10.1097/DSS.0000000000001706.
- Ko CJ, Myung P, Leffell DJ, Bourdon JC. Cutaneous immunohistochemical staining pattern of p53β isoforms. Journal Of Clinical Pathology 2018, 71: 1120-1122. PMID: 30305316, DOI: 10.1136/jclinpath-2018-205098.
- Totonchy MB, Leventhal JS, Ko CJ, Leffell DJ. Hypertrophic Lichen Planus and Well-Differentiated Squamous Cell Carcinoma: A Diagnostic Conundrum. Dermatologic Surgery : Official Publication For American Society For Dermatologic Surgery [et Al.] 2018, 44: 1466-1470. PMID: 29360655, DOI: 10.1097/DSS.0000000000001465.
- Ferrucci LM, Cartmel B, Clare RA, Choy CC, Kershaw T, Leffell DJ, Mayne ST. Cross-sectional assessment of ultraviolet radiation-related behaviors among young people after a diagnosis of melanoma or basal cell carcinoma. Journal Of The American Academy Of Dermatology 2018, 79: 149-152. PMID: 29291957, PMCID: PMC6004335, DOI: 10.1016/j.jaad.2017.12.056.
- Ezaldein HH, Scott JF, Yin ES, Ventura A, DeRuyter NP, Leffell DJ. Transparency and Dermatologic Device Approval by the US Food and Drug Administration. JAMA Dermatology 2018, 154: 273-280. PMID: 29365020, PMCID: PMC5885836, DOI: 10.1001/jamadermatol.2017.5757.
- Ko CJ, Glusac EJ, McNiff JM, Rodic N, Leffell DJ. Squamous proliferations on the legs of women: Qualitative examination of histopathology, TP53 sequencing, and implications for diagnosis in a series of 30 cases. Journal Of The American Academy Of Dermatology 2017, 77: 1126-1132.e1. PMID: 28709693, DOI: 10.1016/j.jaad.2017.04.1119.
- Cartmel B, Bale AE, Mayne ST, Gelernter JE, DeWan AT, Spain P, Leffell DJ, Pagoto S, Ferrucci LM. Predictors of tanning dependence in white non-Hispanic females and males. Journal Of The European Academy Of Dermatology And Venereology : JEADV 2017, 31: 1223-1228. PMID: 28129487, PMCID: PMC5522341, DOI: 10.1111/jdv.14138.
- Panse G, Cowper SE, Leffell DJ, Pulitzer M, Ko CJ. Well-differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63. Journal Of Cutaneous Pathology 2017, 44: 557-562. PMID: 28417484, DOI: 10.1111/cup.12952.
- Zhang Y, Cartmel B, Choy CC, Molinaro AM, Leffell DJ, Bale AE, Mayne ST, Ferrucci LM. Body mass index, height and early-onset basal cell carcinoma in a case-control study. Cancer Epidemiology 2017, 46: 66-72. PMID: 28039770, PMCID: PMC5272867, DOI: 10.1016/j.canep.2016.12.007.
- Totonchy M, Leffell D. Emerging concepts and recent advances in basal cell carcinoma. F1000Research 2017, 6: 2085. PMID: 29259776, PMCID: PMC5717469, DOI: 10.12688/f1000research.11314.1.
- Munday WR, Leffell DJ, McNiff JM, Ko CJ. Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity. Journal Of Cutaneous Pathology 2016, 43: 759-65. PMID: 27220356, DOI: 10.1111/cup.12738.
- Christensen SR, McNiff JM, Cool AJ, Aasi SZ, Hanlon AM, Leffell DJ. Histopathologic assessment of depth of follicular invasion of squamous cell carcinoma (SCC) in situ (SCCis): Implications for treatment approach. Journal Of The American Academy Of Dermatology 2016, 74: 356-62. PMID: 26670714, DOI: 10.1016/j.jaad.2015.09.060.
- Berlin NL, Cartmel B, Leffell DJ, Bale AE, Mayne ST, Ferrucci LM. Family history of skin cancer is associated with early-onset basal cell carcinoma independent of MC1R genotype. Cancer Epidemiology 2015, 39: 1078-83. PMID: 26381319, PMCID: PMC4679454, DOI: 10.1016/j.canep.2015.09.005.
- Izikson R, Leffell DJ, Bock SA, Patriarca PA, Post P, Dunkle LM, Cox MM. Randomized comparison of the safety of Flublok(®) versus licensed inactivated influenza vaccine in healthy, medically stable adults ≥ 50 years of age. Vaccine 2015, 33: 6622-8. PMID: 26529070, DOI: 10.1016/j.vaccine.2015.10.097.
- Higgins HW, Lee KC, Galan A, Leffell DJ. Melanoma in situ: Part I. Epidemiology, screening, and clinical features. Journal Of The American Academy Of Dermatology 2015, 73: 181-90, quiz 191-2. PMID: 26183967, DOI: 10.1016/j.jaad.2015.04.014.
- Berlin NL, Ferrucci LM, Cartmel B, Wang SY, Leffell DJ, McNiff JM, Mayne ST. Subsequent skin cancer in patients with early-onset basal cell carcinoma. The Australasian Journal Of Dermatology 2015, 56: 236-7. PMID: 26201376, DOI: 10.1111/ajd.12338.
- Higgins HW, Lee KC, Galan A, Leffell DJ. Melanoma in situ: Part II. Histopathology, treatment, and clinical management. Journal Of The American Academy Of Dermatology 2015, 73: 193-203; quiz 203-4. PMID: 26183968, DOI: 10.1016/j.jaad.2015.03.057.
- Indoor tanning and the MC1R genotype: risk prediction for basal cell carcinoma risk in young people.Molinaro AM, Ferrucci LM, Cartmel B, Loftfield E, Leffell DJ, Bale AE, Mayne ST. Indoor tanning and the MC1R genotype: risk prediction for basal cell carcinoma risk in young people. American Journal Of Epidemiology 2015, 181: 908-16. PMID: 25858289, PMCID: PMC4445390, DOI: 10.1093/aje/kwu356.
- Mendez JJ, Ghaedi M, Sivarapatna A, Dimitrievska S, Shao Z, Osuji CO, Steinbacher DM, Leffell DJ, Niklason LE. Mesenchymal stromal cells form vascular tubes when placed in fibrin sealant and accelerate wound healing in vivo. Biomaterials 2015, 40: 61-71. PMID: 25433608, PMCID: PMC4268422, DOI: 10.1016/j.biomaterials.2014.11.011.
- Kim J, Singh Maan H, Cool AJ, Hanlon AM, Leffell DJ. Fast Absorbing Gut Suture versus Cyanoacrylate Tissue Adhesive in the Epidermal Closure of Linear Repairs Following Mohs Micrographic Surgery. The Journal Of Clinical And Aesthetic Dermatology 2015, 8: 24-9. PMID: 25741400, PMCID: PMC4345930.
- Goldberg C, Hoang D, McRae M, Chung C, Leffell DJ, Narayan D. A strategy for the successful management of dermatofibrosarcoma protuberans. Annals Of Plastic Surgery 2015, 74: 80-4. PMID: 23788146, DOI: 10.1097/SAP.0b013e3182898692.
- Zhang Y, Ferrucci LM, Cartmel B, Molinaro AM, Leffell DJ, Bale AE, Mayne ST. Alcohol intake and early-onset basal cell carcinoma in a case-control study. The British Journal Of Dermatology 2014, 171: 1451-7. PMID: 25059635, PMCID: PMC4272627, DOI: 10.1111/bjd.13291.
- Cartmel B, Dewan A, Ferrucci LM, Gelernter J, Stapleton J, Leffell DJ, Mayne ST, Bale AE. Novel gene identified in an exome-wide association study of tanning dependence. Experimental Dermatology 2014, 23: 757-9. PMID: 25041255, PMCID: PMC4204712, DOI: 10.1111/exd.12503.
- Troche JR, Ferrucci LM, Cartmel B, Leffell DJ, Bale AE, Mayne ST. Systemic glucocorticoid use and early-onset basal cell carcinoma. Annals Of Epidemiology 2014, 24: 625-7. PMID: 24958637, PMCID: PMC4119504, DOI: 10.1016/j.annepidem.2014.05.009.
- Ferrucci LM, Cartmel B, Molinaro AM, Leffell DJ, Bale AE, Mayne ST. Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case-control study. European Journal Of Cancer Prevention : The Official Journal Of The European Cancer Prevention Organisation (ECP) 2014, 23: 296-302. PMID: 24841641, PMCID: PMC4059399, DOI: 10.1097/CEJ.0000000000000037.
- Kim C, Ko CJ, Leffell DJ. Cutaneous squamous cell carcinomas of the lower extremity: a distinct subset of squamous cell carcinomas. Journal Of The American Academy Of Dermatology 2014, 70: 70-4. PMID: 24210370, DOI: 10.1016/j.jaad.2013.09.026.
- Higgins HW, Lee KC, Leffell DJ. Point of care cutaneous imaging technology in melanoma screening and mole mapping. F1000prime Reports 2014, 6: 34. PMID: 24860656, PMCID: PMC4017910, DOI: 10.12703/P6-34.
- Hanlon A, Kim J, Leffell DJ. Intralesional interferon alfa-2b for refractory, recurrent squamous cell carcinoma of the face. Journal Of The American Academy Of Dermatology 2013, 69: 1070-2. PMID: 24238178, DOI: 10.1016/j.jaad.2013.02.032.
- Scarmo S, Cartmel B, Lin H, Leffell DJ, Ermakov IV, Gellermann W, Bernstein PS, Mayne ST. Single v. multiple measures of skin carotenoids by resonance Raman spectroscopy as a biomarker of usual carotenoid status. The British Journal Of Nutrition 2013, 110: 911-7. PMID: 23351238, PMCID: PMC3696054, DOI: 10.1017/S000711451200582X.
- Cartmel B, Ferrucci LM, Spain P, Bale AE, Pagoto SL, Leffell DJ, Gelernter J, Mayne ST. Indoor tanning and tanning dependence in young people after a diagnosis of basal cell carcinoma. JAMA Dermatology 2013, 149: 1110-1. PMID: 23824273, PMCID: PMC3782995, DOI: 10.1001/jamadermatol.2013.5104.
- Bunick CG, Leffell D, Bosenberg M, Yahalom J, Choi JN. Cutaneous Rosai-Dorfman disease of the right ear responsive to radiotherapy. Journal Of The American Academy Of Dermatology 2012, 67: e225-6. PMID: 23062927, DOI: 10.1016/j.jaad.2012.04.025.
- Ferrucci LM, Cartmel B, Molinaro AM, Leffell DJ, Bale AE, Mayne ST. Indoor tanning and risk of early-onset basal cell carcinoma. Journal Of The American Academy Of Dermatology 2012, 67: 552-62. PMID: 22153793, PMCID: PMC3307842, DOI: 10.1016/j.jaad.2011.11.940.
- Ferrucci LM, Cartmel B, Molinaro AM, Gordon PB, Leffell DJ, Bale AE, Mayne ST. Host phenotype characteristics and MC1R in relation to early-onset basal cell carcinoma. The Journal Of Investigative Dermatology 2012, 132: 1272-9. PMID: 22158557, PMCID: PMC3305835, DOI: 10.1038/jid.2011.402.
- Jedrych J, Leffell D, McNiff JM. Desmoplastic trichoepithelioma with perineural involvement: a series of seven cases. Journal Of Cutaneous Pathology 2012, 39: 317-23. PMID: 22335590, DOI: 10.1111/j.1600-0560.2012.01876.x.
- Lostritto K, Ferrucci LM, Cartmel B, Leffell DJ, Molinaro AM, Bale AE, Mayne ST. Lifetime history of indoor tanning in young people: a retrospective assessment of initiation, persistence, and correlates. BMC Public Health 2012, 12: 118. PMID: 22324969, PMCID: PMC3340300, DOI: 10.1186/1471-2458-12-118.
- Heffelfinger C, Ouyang Z, Engberg A, Leffell DJ, Hanlon AM, Gordon PB, Zheng W, Zhao H, Snyder MP, Bale AE. Correlation of Global MicroRNA Expression With Basal Cell Carcinoma Subtype. G3 (Bethesda, Md.) 2012, 2: 279-86. PMID: 22384406, PMCID: PMC3284335, DOI: 10.1534/g3.111.001115.
- Choi JN, Hanlon A, Leffell D. Melanoma and nevi: detection and diagnosis. Current Problems In Cancer 2011, 35: 138-61. PMID: 21911179, DOI: 10.1016/j.currproblcancer.2011.07.005.
- Scarmo S, Cartmel B, Lin H, Leffell DJ, Welch E, Bhosale P, Bernstein PS, Mayne ST. Significant correlations of dermal total carotenoids and dermal lycopene with their respective plasma levels in healthy adults. Archives Of Biochemistry And Biophysics 2010, 504: 34-9. PMID: 20637178, PMCID: PMC2957565, DOI: 10.1016/j.abb.2010.07.004.
- Mayne ST, Cartmel B, Scarmo S, Lin H, Leffell DJ, Welch E, Ermakov I, Bhosale P, Bernstein PS, Gellermann W. Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake. The American Journal Of Clinical Nutrition 2010, 92: 794-800. PMID: 20685953, PMCID: PMC3133234, DOI: 10.3945/ajcn.2010.29707.
- Terushkin E, Leffell DJ, Futoryan T, Cowper S, Lazova R. Squamoid eccrine ductal carcinoma: a case report and review of the literature. The American Journal Of Dermatopathology 2010, 32: 287-292. PMID: 20010402, DOI: 10.1097/DAD.0b013e3181b623c4.
- Ko CJ, Leffell DJ, McNiff JM. Adenosquamous carcinoma: a report of nine cases with p63 and cytokeratin 5/6 staining. Journal Of Cutaneous Pathology 2009, 36: 448-52. PMID: 19278431, DOI: 10.1111/j.1600-0560.2008.01083.x.
- Mariwalla K, Aasi SZ, Glusac EJ, Leffell DJ. Mohs micrographic surgery histopathology concordance. Journal Of The American Academy Of Dermatology 2009, 60: 94-8. PMID: 19103361, PMCID: PMC2632938, DOI: 10.1016/j.jaad.2008.09.061.
- Neville JA, Welch E, Leffell DJ. Management of nonmelanoma skin cancer in 2007. Nature Clinical Practice. Oncology 2007, 4: 462-9. PMID: 17657251, DOI: 10.1038/ncponc0883.
- Newman JC, Leffell DJ. Correlation of embryonic fusion planes with the anatomical distribution of basal cell carcinoma. Dermatologic Surgery : Official Publication For American Society For Dermatologic Surgery [et Al.] 2007, 33: 957-64; discussion 965. PMID: 17661939, DOI: 10.1111/j.1524-4725.2007.33198.x.
- Bhattacharjee P, Leffell D, McNiff JM. Primary cutaneous carcinosarcoma arising in a patient with nevoid basal cell carcinoma syndrome. Journal Of Cutaneous Pathology 2005, 32: 638-41. PMID: 16176303, DOI: 10.1111/j.0303-6987.2005.00384.x.
- Pennington BE, Leffell DJ. Mohs micrographic surgery: established uses and emerging trends. Oncology (Williston Park, N.Y.) 2005, 19: 1165-71; discussion 1171-2, 1175. PMID: 16255133.
- Asplund A, Gustafsson AC, Wikonkal NM, Sela A, Leffell DJ, Kidd K, Lundeberg J, Brash DE, Pontén F. PTCH codon 1315 polymorphism and risk for nonmelanoma skin cancer. The British Journal Of Dermatology 2005, 152: 868-73. PMID: 15888139, DOI: 10.1111/j.1365-2133.2005.06464.x.
- Aasi SZ, Leffell DJ. Bilobed transposition flap. Dermatologic Clinics 2005, 23: 55-64, vi. PMID: 15620619, DOI: 10.1016/j.det.2004.08.004.
- Aasi SZ, Leffell DJ. Complications in dermatologic surgery: how safe is safe? Archives Of Dermatology 2003, 139: 213-4. PMID: 12588228, DOI: 10.1001/archderm.139.2.213.
- Leffell DJ. Clinical efficacy of devices for nonablative photorejuvenation. Archives Of Dermatology 2002, 138: 1503-8. PMID: 12437458, DOI: 10.1001/archderm.138.11.1503.
- Olhoffer IH, Lazova R, Leffell DJ. Histopathologic misdiagnoses and their clinical consequences. Archives Of Dermatology 2002, 138: 1381-3. PMID: 12374557, DOI: 10.1001/archderm.138.10.1381.
- Carucci JA, Kolenik SA, Leffell DJ. Human cadaveric allograft for repair of nasal defects after extirpation of Basal cell carcinoma by Mohs micrographic surgery. Dermatologic Surgery : Official Publication For American Society For Dermatologic Surgery [et Al.] 2002, 28: 340-3. PMID: 11966793, DOI: 10.1046/j.1524-4725.2002.01143.x.
- Carucci JA, Kolenik SA, Leffell DJ. Repair of a defect of the lower lip. Dermatologic Surgery : Official Publication For American Society For Dermatologic Surgery [et Al.] 2002, 28: 195-6. PMID: 11860438, DOI: 10.1046/j.1524-4725.2002.01250.x.
- Chen T, Yan W, Wells RG, Rimm DL, McNiff J, Leffell D, Reiss M. Novel inactivating mutations of transforming growth factor-beta type I receptor gene in head-and-neck cancer metastases. International Journal Of Cancer. Journal International Du Cancer 2001, 93: 653-61. PMID: 11477574, DOI: 10.1002/ijc.1381.
- Alexey TestSome citation
- Leffell DJ, Arndt KA. The dermatologic surgery issue: A new face for the ARCHIVES Archives Of Dermatology 2000, 136: 1404. PMID: 11074706, DOI: 10.1001/archderm.136.11.1404.
- Hahn H, Wicking C, Zaphiropoulous PG, Gailani MR, Shanley S, Chidambaram A, Vorechovsky I, Holmberg E, Unden AB, Gillies S, Negus K, Smyth I, Pressman C, Leffell DJ, Gerrard B, Goldstein AM, Dean M, Toftgard R, Chenevix-Trench G, Wainwright B, Bale AE. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 1996, 85: 841-51. PMID: 8681379.
- Ziegler A, Jonason A, Simon J, Leffell D, Brash DE. Tumor suppressor gene mutations and photocarcinogenesis. Photochemistry And Photobiology 1996, 63: 432-5. PMID: 8934758.
- Gailani MR, Leffell DJ, Ziegler A, Gross EG, Brash DE, Bale AE. Relationship between sunlight exposure and a key genetic alteration in basal cell carcinoma. Journal Of The National Cancer Institute 1996, 88: 349-54. PMID: 8609643.
- Ziegler A, Jonason AS, Leffell DJ, Simon JA, Sharma HW, Kimmelman J, Remington L, Jacks T, Brash DE. Sunburn and p53 in the onset of skin cancer. Nature 1994, 372: 773-6. PMID: 7997263, DOI: 10.1038/372773a0.
- Ziegler A, Leffell DJ, Kunala S, Sharma HW, Gailani M, Simon JA, Halperin AJ, Baden HP, Shapiro PE, Bale AE. Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 4216-20. PMID: 8483937, PMCID: PMC46477.
- Leffell DJ, Headington JT, Wong DS, Swanson NA. Aggressive-growth basal cell carcinoma in young adults. Archives Of Dermatology 1991, 127: 1663-7. PMID: 1952969.
- Leffell DJ, Stetz ML, Milstone LM, Deckelbaum LI. In vivo fluorescence of human skin. A potential marker of photoaging. Archives Of Dermatology 1988, 124: 1514-8. PMID: 3421727.
- Dillon JG, Wade CW, Daly WH. Enzyme immobilization on fibrin. Biotechnol Bioeng 1976, 18: 133-9. PMID: 2354, DOI: 10.1002/bit.260180112.
- Goss DJ, Parkhurst LJ, Görisch H. Kinetic light scattering studies on the dissociation of hemoglobin from Lumbricus terrestris. Biochemistry 1975, 14: 5461-4. PMID: 56, DOI: 10.1021/bi00696a012.
- Kaizu T, Margolius HS. Studies on rat renal cortical cell kallikrein. I. Separation and measurement. Biochim Biophys Acta 1975, 411: 305-15. PMID: 78, DOI: 10.1016/0304-4165(75)90310-4.
- McPhie P. The origin of the alkaline inactivation of pepsinogen. Biochemistry 1975, 14: 5253-6. PMID: 44, DOI: 10.1021/bi00695a003.
- Hattori M, Frazier J, Miles HT. Poly(8-aminoguanylic acid): formation of ordered self-structures and interaction with poly(cytidylic acid). Biochemistry 1975, 14: 5033-45. PMID: 37, DOI: 10.1021/bi00694a002.
- Garner CW, Behal FJ. Effect of pH on substrate and inhibitor kinetic constants of human liver alanine aminopeptidase. Evidence for two ionizable active center groups. Biochemistry 1975, 14: 5084-8. PMID: 38, DOI: 10.1021/bi00694a009.
- Sanner T. Formation of transient complexes in the glutamate dehydrogenase catalyzed reaction. Biochemistry 1975, 14: 5094-8. PMID: 39, DOI: 10.1021/bi00694a011.
- Stellwagen E, Babul J. Stabilization of the globular structure of ferricytochrome c by chloride in acidic solvents. Biochemistry 1975, 14: 5135-40. PMID: 41, DOI: 10.1021/bi00694a018.
- Orskov ER, Fraser C. The effects of processing of barley-based supplements on rumen pH, rate of digestion of voluntary intake of dried grass in sheep. Br J Nutr 1975, 34: 493-500. PMID: 36, DOI: 10.1017/s0007114575000530.
- Christensen H, Felby S. Dibenzepine and its metabolites in blood, muscle, liver, vitreous body and urine from fatal poisoning. Acta Pharmacol Toxicol (Copenh) 1975, 37: 393-401. PMID: 888, DOI: 10.1111/j.1600-0773.1975.tb00858.x.
- Abraham KA, Eikhom TS. Determination of polyadenylate-rich ribonucleic acid in the nucleus and in the cytoplasm of plasmacytoma cells. Biochem J 1975, 149: 669-74. PMID: 999, DOI: 10.1042/bj1490669.
- Runcan V, Oproiu A, State I, Vlădăreanu S. [Prolonged treatment with prednisone and azathioprine in chronic hepatitis with immunological disorders]. Rev Med Interna Neurol Psihiatr Neurochir Dermatovenerol Med Interna 1975, 27: 273-7. PMID: 777.
- Worathumrong N, Grimes AJ. The effect of o-salicylate upon pentose phosphate pathway activity in normal and G6PD-deficient red cells. Br J Haematol 1975, 30: 225-31. PMID: 35, DOI: 10.1111/j.1365-2141.1975.tb00536.x.
- . Gastroduodenal emptying and motility. Scand J Gastroenterol Suppl 1975, 35: 1-87. PMID: 787.
- Yale Dermatologic SurgeryTemple Medical Center40 Temple Street, Ste 5th Floor, Suite 5ANew Haven, CT 06510