- Smilow Cancer Hospital Gastrointestinal Cancers ProgramTrumbull Care Center5520 Park AvenueTrumbull, CT 06611
- Smilow Cancer Hospital Melanoma ProgramTrumbull Care Center5520 Park AvenueTrumbull, CT 06611
- Yale Surgical OncologySmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
- Yale Surgical OncologyBridgeport Hospital267 Grant StreetBridgeport, CT 06610
Sajid A Khan, MD, FACS, FSSO
Biography
Sajid A. Khan, MD, is a surgical oncologist who treats both malignant (cancer) and premalignant tumors. He specializes in complex general surgical oncology and general surgery, and is dedicated to improving the lives of cancer patients through his clinical practice and research endeavors. He specializes in the surgical management of tumors that affect the pancreas, liver, bile duct, gallbladder, stomach, colon and rectum. He also provides surgery for patients with skin cancer and soft tissue sarcomas.
Dr. Khan believes patients do best when medical professionals work cohesively as a team. He appreciates being able to draw upon the expertise of a variety of specialists to collaborate in identifying the best approach to each patient’s case. He uses minimally invasive surgical techniques whenever possible.
He says one of the most important aspects of his work as a surgeon—especially one who treats cancer—is his ability to develop relationships with patients and their family before any operation. Dr. Khan takes the time to get to know his patients, providing each with a detailed description of their diagnosis and an explanation of how treatment will proceed. He is careful to answer all of their questions about the surgery and other treatments they will undergo as part of their multidisciplinary cancer treatment plan.
“I tell my patients that my care for them is a long-term commitment that extends well beyond the perioperative period,” Dr. Khan says. “I communicate with other cancer specialists in Yale Medicine to provide a comprehensive, team approach to their care.”
As an assistant professor of surgery (oncology), Dr. Khan is also devoted to performing research that will help improve care for cancer patients. “I am very passionate about my work studying the tumor biology of cancer metastasis,” he says. He is currently working on research to identify which patients with a limited number of metastases (oligometastasis) will benefit most from curative therapies, including surgery.
Titles
- Associate Professor of Surgery (Oncology)
- Section Chief, Hepato-Pancreato-Biliary (HPB) and Mixed Tumors
- Co-Director of Team Science, Yale Center for Clinical Investigation (YCCI)
Education & Training
- Fellowship (Clinical)University of Chicago Medical Center (2013)
- Residency (Chief)Oregon Health and Science University (2010)
- ResidencyOregon Health and Science University (2009)
- Fellowship (Research)Memorial Sloan-Kettering Cancer Center (2007)
- ResidencyAlbert Einstein College of Medicine/Montefiore Medical Center (2005)
- MDState University of New York Upstate Medical University (2003)
- BSSiena College, Biology (1999)
Languages Spoken
- English
- हिन्दी (Hindi)
- اردو (Urdu)
Additional Information
- National Top Doctor Award: Castle Connolly (2022)
- Best Doctors: Connecticut Magazine (2021)
- Regional Top Doctor Award: Castle Connolly (2021)
- Fairfield County's Top Doctor: Westport Magazine, Fairfield Living Magazine, Greenwich Magazine, New-Canaan-Darien Magazine, Stamford Magazine (2020)
- Regional Top Doctor, Surgery: Castle Connolly (2020)
- Regional Top Doctor, Surgery: Castle Connolly (2019)
- Poster Grand Rounds Top 5 Scoring Posters: Society of Surgical Oncology Scientific Program (2019)
- New York Metro Area Top Doctor: Castle Connolly (2018)
- Fairfield County's Top Doctors: Westport Magazine and Greenwich Magazine (2018)
- Clinical Translational Science Award Scholar: National Institutes of Health/Yale Center for Clinical Investigation (2017)
- AB of Surgery, Complex General Surgical Oncology (2015)
- Association for Academic Surgery (2021 - Present): Member
- Society for Surgery of the Alimentary Tract (SSAT), Research Committee (2019 - Present): Committee Member
- Society of Surgical Oncology (SSO), Colorectal Disease Site Working Group (2019 - Present): Committee Member
- National Comprehensive Cancer Network (NCCN) (2017 - Present): Neuroendocrine Tumor Panel Committee, Member
- Yale School of Medicine (2017 - Present): Admissions Committee, Member
- Smilow Cancer Hospital (2016 - Present): Park Avenue Medical Center Advisory Board
- America Hepato-Pancreato-Biliary Association (AHPBA) (2016 - 2019): Research Committee, Member
- New England Surgical Society (NESS) (2015 - Present): Member
- Yale Cancer Center, Protocol Review Committee (2015 - 2019): Committee Member
- Society for Surgery of the Alimentary Tract (SSAT) (2015 - 2018): Program Subcommittee Small Bowel, Member
- Kerekes DM, Khan SA. Lipid Metabolism in Biliary Tract Cancer: A New Therapeutic Target? Annals Of Surgical Oncology 2022, 29: 2750-2751. PMID: 35243594, DOI: 10.1245/s10434-022-11383-w.
- Bakkila BF, Kerekes D, Nunez-Smith M, Billingsley KG, Ahuja N, Wang K, Oladele C, Johnson CH, Khan SA. Evaluation of Racial Disparities in Quality of Care for Patients With Gastrointestinal Tract Cancer Treated With Surgery. JAMA Network Open 2022, 5: e225664. PMID: 35377425, PMCID: PMC8980937, DOI: 10.1001/jamanetworkopen.2022.5664.
- Shen X, Cai Y, Lu L, Huang H, Yan H, Paty PB, Muca E, Ahuja N, Zhang Y, Johnson CH, Khan SA. Asparagine Metabolism in Tumors Is Linked to Poor Survival in Females with Colorectal Cancer: A Cohort Study. Metabolites 2022, 12 PMID: 35208238, PMCID: PMC8875032, DOI: 10.3390/metabo12020164.
- Hasan NM, Sharma A, Ruzgar NM, Deshpande H, Olino K, Khan S, Ahuja N. Epigenetic signatures differentiate uterine and soft tissue leiomyosarcoma. Oncotarget 2021, 12: 1566-1579. PMID: 34381562, PMCID: PMC8351604, DOI: 10.18632/oncotarget.28032.
- Shah MH, Goldner WS, Benson AB, Bergsland E, Blaszkowsky LS, Brock P, Chan J, Das S, Dickson PV, Fanta P, Giordano T, Halfdanarson TR, Halperin D, He J, Heaney A, Heslin MJ, Kandeel F, Kardan A, Khan SA, Kuvshinoff BW, Lieu C, Miller K, Pillarisetty VG, Reidy D, Salgado SA, Shaheen S, Soares HP, Soulen MC, Strosberg JR, Sussman CR, Trikalinos NA, Uboha NA, Vijayvergia N, Wong T, Lynn B, Hochstetler C. Neuroendocrine and Adrenal Tumors, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network : JNCCN 2021, 19: 839-868. PMID: 34340212, DOI: 10.6004/jnccn.2021.0032.
- Cai Y, Kim DJ, Takahashi T, Broadhurst DI, Yan H, Ma S, Rattray NJW, Casanovas-Massana A, Israelow B, Klein J, Lucas C, Mao T, Moore AJ, Muenker MC, Oh JE, Silva J, Wong P, Ko AI, Khan SA, Iwasaki A, Johnson CH. Kynurenic acid may underlie sex-specific immune responses to COVID-19. Science Signaling 2021, 14 PMID: 34230210, PMCID: PMC8432948, DOI: 10.1126/scisignal.abf8483.
- Zhu G, Su H, Johnson CH, Khan SA, Kluger H, Lu L. Intratumour microbiome associated with the infiltration of cytotoxic CD8+ T cells and patient survival in cutaneous melanoma. European Journal Of Cancer (Oxford, England : 1990) 2021, 151: 25-34. PMID: 33962358, PMCID: PMC8184628, DOI: 10.1016/j.ejca.2021.03.053.
- Tian J, Zhang D, Kurbatov V, Wang Q, Wang Y, Fang D, Wu L, Bosenberg M, Muzumdar MD, Khan S, Lu Q, Yan Q, Lu J. 5-Fluorouracil efficacy requires anti-tumor immunity triggered by cancer-cell-intrinsic STING. The EMBO Journal 2021, 40: e106065. PMID: 33615517, PMCID: PMC8013832, DOI: 10.15252/embj.2020106065.
- Miccio JA, Talcott WJ, Patel T, Park HS, Cecchini M, Salem RR, Khan SA, Stein S, Kortmansky JS, Lacy J, Narang A, Herman J, Jabbour SK, Hallemeier CL, Johung K, Jethwa KR. Margin negative resection and pathologic downstaging with multiagent chemotherapy with or without radiotherapy in patients with localized pancreas cancer: A national cancer database analysis. Clinical And Translational Radiation Oncology 2021, 27: 15-23. PMID: 33392398, PMCID: PMC7772693, DOI: 10.1016/j.ctro.2020.12.003.
- Cai Y, Kim DJ, Takahashi T, Broadhurst DI, Ma S, Rattray NJW, Casanovas-Massana A, Israelow B, Klein J, Lucas C, Mao T, Moore AJ, Muenker MC, Oh J, Silva J, Wong P, Ko AJ, Khan SA, Iwasaki A, Johnson CH. Kynurenic acid underlies sex-specific immune responses to COVID-19. MedRxiv : The Preprint Server For Health Sciences 2020 PMID: 32935119, PMCID: PMC7491534, DOI: 10.1101/2020.09.06.20189159.
- Liu S, Heller DR, Jean RA, Chiu AS, Khan SA, Dardik A. Palliative care is underutilized and affects healthcare costs in ruptured abdominal aortic aneurysms. Surgery 2020, 168: 234-236. PMID: 32139140, PMCID: PMC7748368, DOI: 10.1016/j.surg.2020.01.017.
- Cai Y, Rattray NJW, Zhang Q, Mironova V, Santos-Neto A, Muca E, Vollmar AKR, Hsu KS, Rattray Z, Cross JR, Zhang Y, Paty PB, Khan SA, Johnson CH. Tumor Tissue-Specific Biomarkers of Colorectal Cancer by Anatomic Location and Stage. Metabolites 2020, 10 PMID: 32575361, PMCID: PMC7345993, DOI: 10.3390/metabo10060257.
- Kurbatov V, Khan SA. Exploring Microsatellite Instability (MSI) in Colorectal Cancer at Elevated Microsatellite Alterations at Selected Tetranucleotides (EMAST). Annals Of Surgical Oncology 2020, 27: 973-974. PMID: 31788754, DOI: 10.1245/s10434-019-08051-x.
- Liu Z, Luo JJ, Pei KY, Khan SA, Wang XX, Zhao ZX, Yang M, Johnson CH, Wang XS, Zhang Y. Joint effect of pre-operative anemia and perioperative blood transfusion on outcomes of colon-cancer patients undergoing colectomy. Gastroenterology Report 2020, 8: 151-157. PMID: 32280475, PMCID: PMC7136710, DOI: 10.1093/gastro/goz033.
- Cai Y, Rattray NJW, Zhang Q, Mironova V, Santos-Neto A, Hsu KS, Rattray Z, Cross JR, Zhang Y, Paty PB, Khan SA, Johnson CH. Sex Differences in Colon Cancer Metabolism Reveal A Novel Subphenotype. Scientific Reports 2020, 10: 4905. PMID: 32184446, PMCID: PMC7078199, DOI: 10.1038/s41598-020-61851-0.
- Kurbatov V, Balayev A, Saffarzadeh A, Heller DR, Boffa DJ, Blasberg JD, Lu J, Khan SA. Digital Inference of Immune Microenvironment Reveals Low-Risk Subtype of Early Lung Adenocarcinoma. The Annals Of Thoracic Surgery 2020, 109: 343-349. PMID: 31568747, DOI: 10.1016/j.athoracsur.2019.08.050.
- Heller DR, Nicolson NG, Ahuja N, Khan S, Kunstman JW. Association of Treatment Inequity and Ancestry With Pancreatic Ductal Adenocarcinoma Survival. JAMA Surgery 2020, 155: e195047. PMID: 31800002, PMCID: PMC6902102, DOI: 10.1001/jamasurg.2019.5047.
- Kurbatov V, Resio BJ, Cama CA, Heller DR, Cha C, Zhang Y, Lu J, Khan SA. Liver-first approach to stage IV colon cancer with synchronous isolated liver metastases. Journal Of Gastrointestinal Oncology 2020, 11: 76-83. PMID: 32175108, PMCID: PMC7052756, DOI: 10.21037/jgo.2020.01.03.
- Sun Y, Mironova V, Chen Y, Lundh EPF, Zhang Q, Cai Y, Vasiliou V, Zhang Y, Garcia-Milian R, Khan SA, Johnson CH. Molecular Pathway Analysis Indicates a Distinct Metabolic Phenotype in Women With Right-Sided Colon Cancer. Translational Oncology 2020, 13: 42-56. PMID: 31760268, PMCID: PMC6883319, DOI: 10.1016/j.tranon.2019.09.004.
- Gene Alterations of N6-Methyladenosine (m6A) Regulators in Colorectal Cancer: A TCGA Database Study.Zhang Q, Cai Y, Kurbatov V, Khan SA, Lu L, Zhang Y, Johnson CH. Gene Alterations of N6-Methyladenosine (m6A) Regulators in Colorectal Cancer: A TCGA Database Study. BioMed Research International 2020, 2020: 8826456. PMID: 33415160, PMCID: PMC7769650, DOI: 10.1155/2020/8826456.
- Tang S, Liu F, Li Y, Zhao L, Wang X, Khan SA, Chen Y, Zhang Y. Treatment Selection and Survival Outcomes in Locally Advanced Proximal Gastric Cancer: A National Cancer Data Base Analysis. Frontiers In Oncology 2020, 10: 537051. PMID: 33102212, PMCID: PMC7546198, DOI: 10.3389/fonc.2020.537051.
- Uhlig J, Sellers CM, Khan SA, Cha C, Kim HS. Hepatocellular carcinoma: Impact of academic setting and hospital volume on patient survival. Surgical Oncology 2019, 31: 111-118. PMID: 31654956, DOI: 10.1016/j.suronc.2019.10.009.
- Heller DR, Jean RA, Khan SA. Appendiceal Carcinoid Tumors: In Reply to Sugarbaker. Journal Of The American College Of Surgeons 2019, 229: 519. PMID: 31655709, DOI: 10.1016/j.jamcollsurg.2019.07.005.
- Heller DR, Jean RA, Khan SA. Lymph Node Status: In Reply to Carr. Journal Of The American College Of Surgeons 2019, 229: 516-517. PMID: 31655706, DOI: 10.1016/j.jamcollsurg.2019.07.007.
- Miccio JA, Jairam V, Gao S, Augustyn A, Oladeru OT, Onderdonk BE, Chowdhary M, Han D, Khan S, Friedlaender G, Lindskog DM, Desphande HA, Osborn H, Roberts KB, Patel KR. Predictors of Lymph Node Involvement by Soft Tissue Sarcoma of the Trunk and Extremity: An Analysis of the National Cancer Database. Cure¯us 2019, 11: e6038. PMID: 31824805, PMCID: PMC6886621, DOI: 10.7759/cureus.6038.
- Luo J, Liu Z, Pei KY, Khan SA, Wang X, Yang M, Wang X, Zhang Y. The Role of Bowel Preparation in Open, Minimally Invasive, and Converted-to-Open Colectomy. The Journal Of Surgical Research 2019, 242: 183-192. PMID: 31085366, DOI: 10.1016/j.jss.2019.02.039.
- Rubinstein JC, Khan SA, Christison-Lagay ER, Cha C. APC Mutational Patterns in Gastric Adenocarcinoma are Enriched for Missense Variants with Associated Decreased Survival. Genes, Chromosomes & Cancer 2019 PMID: 31353684, DOI: 10.1002/gcc.22792.
- Klemen ND, Wang M, Feingold PL, Cooper K, Pavri SN, Han D, Detterbeck FC, Boffa DJ, Khan SA, Olino K, Clune J, Ariyan S, Salem RR, Weiss SA, Kluger HM, Sznol M, Cha C. Patterns of failure after immunotherapy with checkpoint inhibitors predict durable progression-free survival after local therapy for metastatic melanoma. Journal For Immunotherapy Of Cancer 2019, 7: 196. PMID: 31340861, PMCID: PMC6657062, DOI: 10.1186/s40425-019-0672-3.
- Uhlig J, Sellers CM, Cha C, Khan SA, Lacy J, Stein SM, Kim HS. Intrahepatic Cholangiocarcinoma: Socioeconomic Discrepancies, Contemporary Treatment Approaches and Survival Trends from the National Cancer Database. Annals Of Surgical Oncology 2019, 26: 1993-2000. PMID: 30693451, DOI: 10.1245/s10434-019-07175-4.
- Pavri SN, Han G, Khan S, Han D. Does sentinel lymph node status have prognostic significance in patients with acral lentiginous melanoma? Journal Of Surgical Oncology 2019, 119: 1060-1069. PMID: 30883783, DOI: 10.1002/jso.25445.
- Heller DR, Jean RA, Luo J, Kurbatov V, Grisotti G, Jacobs D, Chiu AS, Zhang Y, Khan SA. Practice Patterns and Guideline Non-Adherence in Surgical Management of Appendiceal Carcinoid Tumors. Journal Of The American College Of Surgeons 2019, 228: 839-851. PMID: 30898583, PMCID: PMC6751559, DOI: 10.1016/j.jamcollsurg.2019.02.050.
- How I Treat Gastric and Esophageal Cancer, Surgery.Khan SA, Kurbatov V, Posner MC. Handbook of Gastrointestinal Cancers: Evidence-Based Treatment and Multidisciplinary Patient Care 2019.
- Wang X, Liu F, Li Y, Tang S, Zhang Y, Chen Y, Khan SA. Comparison on Clinicopathological Features, Treatments and Prognosis between Proximal Gastric Cancer and Distal Gastric Cancer: A National Cancer Data Base Analysis. Journal Of Cancer 2019, 10: 3145-3153. PMID: 31289585, PMCID: PMC6603385, DOI: 10.7150/jca.30371.
- Heller DR, Jean RA, Chiu AS, Feder SI, Kurbatov V, Cha C, Khan SA. Regional Differences in Palliative Care Utilization Among Geriatric Colorectal Cancer Patients Needing Emergent Surgery. Journal Of Gastrointestinal Surgery : Official Journal Of The Society For Surgery Of The Alimentary Tract 2019, 23: 153-162. PMID: 30328071, PMCID: PMC6751557, DOI: 10.1007/s11605-018-3929-0.
- Blakaj A, Stein SM, Khan SA, Johung KL. Review and current state of radiation therapy for locally advanced pancreatic adenocarcinoma. Journal Of Gastrointestinal Oncology 2018, 9: 1027-1036. PMID: 30603121, PMCID: PMC6286948, DOI: 10.21037/jgo.2018.03.07.
- Pitroda SP, Khodarev NN, Huang L, Uppal A, Wightman SC, Ganai S, Joseph N, Pitt J, Brown M, Forde M, Mangold K, Xue L, Weber C, Segal JP, Kadri S, Stack ME, Khan S, Paty P, Kaul K, Andrade J, White KP, Talamonti M, Posner MC, Hellman S, Weichselbaum RR. Author Correction: Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis. Nature Communications 2018, 9: 4827. PMID: 30425251, PMCID: PMC6233186, DOI: 10.1038/s41467-018-07303-w.
- Shah MH, Goldner WS, Halfdanarson TR, Bergsland E, Berlin JD, Halperin D, Chan J, Kulke MH, Benson AB, Blaszkowsky LS, Eads J, Engstrom PF, Fanta P, Giordano T, He J, Heslin MJ, Kalemkerian GP, Kandeel F, Khan SA, Kidwai WZ, Kunz PL, Kuvshinoff BW, Lieu C, Pillarisetty VG, Saltz L, Sosa JA, Strosberg JR, Sussman CA, Trikalinos NA, Uboha NA, Whisenant J, Wong T, Yao JC, Burns JL, Ogba N, Zuccarino-Catania G. NCCN Guidelines Insights: Neuroendocrine and Adrenal Tumors, Version 2.2018. Journal Of The National Comprehensive Cancer Network : JNCCN 2018, 16: 693-702. PMID: 29891520, DOI: 10.6004/jnccn.2018.0056.
- Zhu R, Liu F, Grisotti G, Perez-Irizarry J, Salem RR, Cha CH, Johung KL, Boffa DJ, Zhang Y, Khan SA. Clinical impact of underutilization of adjuvant therapy in node positive gastric adenocarcinoma. Journal Of Gastrointestinal Oncology 2018, 9: 517-526. PMID: 29998017, PMCID: PMC6006033, DOI: 10.21037/jgo.2018.03.05.
- Pitroda SP, Khodarev NN, Huang L, Uppal A, Wightman SC, Ganai S, Joseph N, Pitt J, Brown M, Forde M, Mangold K, Xue L, Weber C, Segal JP, Kadri S, Stack ME, Khan S, Paty P, Kaul K, Andrade J, White KP, Talamonti M, Posner MC, Hellman S, Weichselbaum RR. Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis. Nature Communications 2018, 9: 1793. PMID: 29728604, PMCID: PMC5935683, DOI: 10.1038/s41467-018-04278-6.
- Zhu R, Liu F, Grisotti G, Pérez-Irizarry J, Cha CH, Johnson CH, Boffa DJ, Han D, Johung KL, Zhang Y, Khan SA. Distinctive features of gastrointestinal stromal tumors arising from the colon and rectum. Journal Of Gastrointestinal Oncology 2018, 9: 231-240. PMID: 29755761, PMCID: PMC5934147, DOI: 10.21037/jgo.2017.11.12.
- Rattray NJW, Deziel NC, Wallach JD, Khan SA, Vasiliou V, Ioannidis JPA, Johnson CH. Beyond genomics: understanding exposotypes through metabolomics. Human Genomics 2018, 12: 4. PMID: 29373992, PMCID: PMC5787293, DOI: 10.1186/s40246-018-0134-x.
- Jacobs D, Zhu R, Luo J, Grisotti G, Heller DR, Kurbatov V, Johnson CH, Zhang Y, Khan SA. Defining Early-Onset Colon and Rectal Cancers. Frontiers In Oncology 2018, 8: 504. PMID: 30460196, PMCID: PMC6232522, DOI: 10.3389/fonc.2018.00504.
- Gao SJ, Park HS, Corso CD, Rutter CE, Khan SA, Johung KL. Post-operative radiotherapy is associated with improved survival in esophageal cancer with positive surgical margins. Journal Of Gastrointestinal Oncology 2017, 8: 953-961. PMID: 29299354, PMCID: PMC5750177, DOI: 10.21037/jgo.2017.08.12.
- Pan W, Zhu S, Qu K, Meeth K, Cheng J, He K, Ma H, Liao Y, Wen X, Roden C, Tobiasova Z, Wei Z, Zhao J, Liu J, Zheng J, Guo B, Khan SA, Bosenberg M, Flavell RA, Lu J. The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression. Immunity 2017, 47: 284-297.e5. PMID: 28813659, PMCID: PMC5710009, DOI: 10.1016/j.immuni.2017.07.020.
- Khan SA, Zeng Z, Shia J, Paty PB. EGFR Gene Amplification and KRAS Mutation Predict Response to Combination Targeted Therapy in Metastatic Colorectal Cancer. Pathology Oncology Research : POR 2017, 23: 673-677. PMID: 28025786, PMCID: PMC5451302, DOI: 10.1007/s12253-016-0166-2.
- Rubinstein JC, Majumdar SK, Laskin W, Lazaga F, Prasad ML, Carling T, Khan SA. Hyperparathyroidism-Jaw Tumor Syndrome Associated With Large-Scale 1q31 Deletion. Journal Of The Endocrine Society 2017, 1: 926-930. PMID: 29264543, PMCID: PMC5686645, DOI: 10.1210/js.2016-1089.
- Liu J, Guo B, Chen Z, Wang N, Iacovino M, Cheng J, Roden C, Pan W, Khan S, Chen S, Kyba M, Fan R, Guo S, Lu J. miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism. Blood 2017, 129: 1491-1502. PMID: 28053194, PMCID: PMC5356452, DOI: 10.1182/blood-2016-06-721027.
- Kole AJ, Stahl JM, Park HS, Khan SA, Johung KL. Predictors of Nonadherence to NCCN Guideline Recommendations for the Management of Stage I Anal Canal Cancer. Journal Of The National Comprehensive Cancer Network : JNCCN 2017, 15: 355-362. PMID: 28275036, DOI: 10.6004/jnccn.2017.0035.
- Predictors of non-adherence to national comprehensive cancer network management guidelines for stage I anal canal cancerKole AJ, Stahl JM, Park HS, Khan SA, Johung KL. Predictors of non-adherence to national comprehensive cancer network management guidelines for stage I anal canal cancer. Journal of National Comprehensive Cancer Network 2017.
- Gastric volvulus after laparoscopic distal pancreatectomy and splenectomy: a case report of a rare post-operative complicationAlkukhun A, Grisotti G, Salem RR, Cha C, Khan SA. Gastric volvulus after laparoscopic distal pancreatectomy and splenectomy: a case report of a rare post-operative complication. In press at American College of Surgeons Case Reviews in Surgery 2017.
- Khan SA, Morris M, Idrees K, Gimbel MI, Rosenberg S, Zeng Z, Li F, Gan G, Shia J, LaQuaglia MP, Paty PB. Colorectal cancer in the very young: a comparative study of tumor markers, pathology and survival in early onset and adult onset patients. Journal Of Pediatric Surgery 2016, 51: 1812-1817. PMID: 27558481, PMCID: PMC5312708, DOI: 10.1016/j.jpedsurg.2016.07.015.
- Zhu R, Grisotti G, Salem RR, Khan SA. Pancreaticoduodenectomy for locally advanced colon cancer in hereditary nonpolyposis colorectal cancer. World Journal Of Surgical Oncology 2016, 14: 12. PMID: 26769110, PMCID: PMC4714509, DOI: 10.1186/s12957-015-0755-7.
- Wightman SC, Uppal A, Pitroda SP, Ganai S, Burnette B, Stack M, Oshima G, Khan S, Huang X, Posner MC, Weichselbaum RR, Khodarev NN. Oncogenic CXCL10 signalling drives metastasis development and poor clinical outcome. British Journal Of Cancer 2015, 113: 327-35. PMID: 26042934, PMCID: PMC4506383, DOI: 10.1038/bjc.2015.193.
- Management of Small Nonfunctional Pancreatic Neuroendocrine Tumor Molecular Cancer TherapeuticsGrisotti G, Khan SA. Management of Small Nonfunctional Pancreatic Neuroendocrine Tumor Molecular Cancer Therapeutics. Difficult Decisions in Hepatobiliary and Pancreatic Surgery – An Evidence Based Approach 2015
- Skin and Subcutaneous TissueKhan SA, Bank J, Choi E, Song D. Skin and Subcutaneous Tissue. Schwartz's Principles of Surgery, Tenth Edition, 2014.
- Khan SA, Matthews JB. Intraoperative margin re-resection for colorectal cancer liver metastases. Hepatobiliary Surgery And Nutrition 2013, 2: 108-12. PMID: 24570924, PMCID: PMC3924657, DOI: 10.3978/j.issn.2304-3881.2012.10.16.
- Pitroda SP, Zhou T, Sweis RF, Filippo M, Labay E, Beckett MA, Mauceri HJ, Liang H, Darga TE, Perakis S, Khan SA, Sutton HG, Zhang W, Khodarev NN, Garcia JG, Weichselbaum RR. Tumor endothelial inflammation predicts clinical outcome in diverse human cancers. PloS One 2012, 7: e46104. PMID: 23056240, PMCID: PMC3464251, DOI: 10.1371/journal.pone.0046104.
- Lussier YA, Khodarev NN, Regan K, Corbin K, Li H, Ganai S, Khan SA, Gnerlich JL, Darga TE, Fan H, Karpenko O, Paty PB, Posner MC, Chmura SJ, Hellman S, Ferguson MK, Weichselbaum RR. Oligo- and polymetastatic progression in lung metastasis(es) patients is associated with specific microRNAs. PloS One 2012, 7: e50141. PMID: 23251360, PMCID: PMC3518475, DOI: 10.1371/journal.pone.0050141.
- Owen RP, Khan SA, Negassa A, Beitler JJ, Bello JA, Brook A, Farinhas J, Garg MK, Haigentz M, Miller TS, Hsu MS, Ravikumar TS, Shifteh K, Smith RV, Silver CE. Radiofrequency ablation of advanced head and neck cancer. Archives Of Otolaryngology--head & Neck Surgery 2011, 137: 493-8. PMID: 21576561, DOI: 10.1001/archoto.2011.62.
- Lussier YA, Xing HR, Salama JK, Khodarev NN, Huang Y, Zhang Q, Khan SA, Yang X, Hasselle MD, Darga TE, Malik R, Fan H, Perakis S, Filippo M, Corbin K, Lee Y, Posner MC, Chmura SJ, Hellman S, Weichselbaum RR. MicroRNA expression characterizes oligometastasis(es). PloS One 2011, 6: e28650. PMID: 22174856, PMCID: PMC3236765, DOI: 10.1371/journal.pone.0028650.
- Esemuede I, Forslund A, Khan SA, Qin LX, Gimbel MI, Nash GM, Zeng Z, Rosenberg S, Shia J, Barany F, Paty PB. Improved testing for microsatellite instability in colorectal cancer using a simplified 3-marker assay. Annals Of Surgical Oncology 2010, 17: 3370-8. PMID: 20703819, PMCID: PMC3269820, DOI: 10.1245/s10434-010-1147-4.
- Cheng YW, Idrees K, Shattock R, Khan SA, Zeng Z, Brennan CW, Paty P, Barany F. Loss of imprinting and marked gene elevation are 2 forms of aberrant IGF2 expression in colorectal cancer. International Journal Of Cancer. Journal International Du Cancer 2010, 127: 568-77. PMID: 19957330, PMCID: PMC3270092, DOI: 10.1002/ijc.25086.
- Cheng YW, Pincas H, Bacolod MD, Schemmann G, Giardina SF, Huang J, Barral S, Idrees K, Khan SA, Zeng Z, Rosenberg S, Notterman DA, Ott J, Paty P, Barany F. CpG island methylator phenotype associates with low-degree chromosomal abnormalities in colorectal cancer. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2008, 14: 6005-13. PMID: 18829479, PMCID: PMC3268558, DOI: 10.1158/1078-0432.CCR-08-0216.
- Zeng ZS, Weiser MR, Kuntz E, Chen CT, Khan SA, Forslund A, Nash GM, Gimbel M, Yamaguchi Y, Culliford AT, D'Alessio M, Barany F, Paty PB. c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases. Cancer Letters 2008, 265: 258-69. PMID: 18395971, PMCID: PMC4367187, DOI: 10.1016/j.canlet.2008.02.049.
- Khan SA, Idrees K, Forslund A, Zeng Z, Rosenberg S, Pincas H, Barany F, Offit K, Laquaglia MP, Paty PB. Genetic variants in germline TP53 and MDM2 SNP309 are not associated with early onset colorectal cancer. Journal Of Surgical Oncology 2008, 97: 621-5. PMID: 18381604, PMCID: PMC4381874, DOI: 10.1002/jso.20996.
- Smilow Cancer Hospital Gastrointestinal Cancers ProgramTrumbull Care Center5520 Park AvenueTrumbull, CT 06611
- Smilow Cancer Hospital Melanoma ProgramTrumbull Care Center5520 Park AvenueTrumbull, CT 06611
- Yale Surgical OncologySmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
- Yale Surgical OncologyBridgeport Hospital267 Grant StreetBridgeport, CT 06610
Biography
Sajid A. Khan, MD, is a surgical oncologist who treats both malignant (cancer) and premalignant tumors. He specializes in complex general surgical oncology and general surgery, and is dedicated to improving the lives of cancer patients through his clinical practice and research endeavors. He specializes in the surgical management of tumors that affect the pancreas, liver, bile duct, gallbladder, stomach, colon and rectum. He also provides surgery for patients with skin cancer and soft tissue sarcomas.
Dr. Khan believes patients do best when medical professionals work cohesively as a team. He appreciates being able to draw upon the expertise of a variety of specialists to collaborate in identifying the best approach to each patient’s case. He uses minimally invasive surgical techniques whenever possible.
He says one of the most important aspects of his work as a surgeon—especially one who treats cancer—is his ability to develop relationships with patients and their family before any operation. Dr. Khan takes the time to get to know his patients, providing each with a detailed description of their diagnosis and an explanation of how treatment will proceed. He is careful to answer all of their questions about the surgery and other treatments they will undergo as part of their multidisciplinary cancer treatment plan.
“I tell my patients that my care for them is a long-term commitment that extends well beyond the perioperative period,” Dr. Khan says. “I communicate with other cancer specialists in Yale Medicine to provide a comprehensive, team approach to their care.”
As an assistant professor of surgery (oncology), Dr. Khan is also devoted to performing research that will help improve care for cancer patients. “I am very passionate about my work studying the tumor biology of cancer metastasis,” he says. He is currently working on research to identify which patients with a limited number of metastases (oligometastasis) will benefit most from curative therapies, including surgery.
Titles
- Associate Professor of Surgery (Oncology)
- Section Chief, Hepato-Pancreato-Biliary (HPB) and Mixed Tumors
- Co-Director of Team Science, Yale Center for Clinical Investigation (YCCI)
Education & Training
- Fellowship (Clinical)University of Chicago Medical Center (2013)
- Residency (Chief)Oregon Health and Science University (2010)
- ResidencyOregon Health and Science University (2009)
- Fellowship (Research)Memorial Sloan-Kettering Cancer Center (2007)
- ResidencyAlbert Einstein College of Medicine/Montefiore Medical Center (2005)
- MDState University of New York Upstate Medical University (2003)
- BSSiena College, Biology (1999)
Languages Spoken
- English
- हिन्दी (Hindi)
- اردو (Urdu)
Additional Information
- National Top Doctor Award: Castle Connolly (2022)
- Best Doctors: Connecticut Magazine (2021)
- Regional Top Doctor Award: Castle Connolly (2021)
- Fairfield County's Top Doctor: Westport Magazine, Fairfield Living Magazine, Greenwich Magazine, New-Canaan-Darien Magazine, Stamford Magazine (2020)
- Regional Top Doctor, Surgery: Castle Connolly (2020)
- Regional Top Doctor, Surgery: Castle Connolly (2019)
- Poster Grand Rounds Top 5 Scoring Posters: Society of Surgical Oncology Scientific Program (2019)
- New York Metro Area Top Doctor: Castle Connolly (2018)
- Fairfield County's Top Doctors: Westport Magazine and Greenwich Magazine (2018)
- Clinical Translational Science Award Scholar: National Institutes of Health/Yale Center for Clinical Investigation (2017)
- AB of Surgery, Complex General Surgical Oncology (2015)
- Association for Academic Surgery (2021 - Present): Member
- Society for Surgery of the Alimentary Tract (SSAT), Research Committee (2019 - Present): Committee Member
- Society of Surgical Oncology (SSO), Colorectal Disease Site Working Group (2019 - Present): Committee Member
- National Comprehensive Cancer Network (NCCN) (2017 - Present): Neuroendocrine Tumor Panel Committee, Member
- Yale School of Medicine (2017 - Present): Admissions Committee, Member
- Smilow Cancer Hospital (2016 - Present): Park Avenue Medical Center Advisory Board
- America Hepato-Pancreato-Biliary Association (AHPBA) (2016 - 2019): Research Committee, Member
- New England Surgical Society (NESS) (2015 - Present): Member
- Yale Cancer Center, Protocol Review Committee (2015 - 2019): Committee Member
- Society for Surgery of the Alimentary Tract (SSAT) (2015 - 2018): Program Subcommittee Small Bowel, Member
- Kerekes DM, Khan SA. Lipid Metabolism in Biliary Tract Cancer: A New Therapeutic Target? Annals Of Surgical Oncology 2022, 29: 2750-2751. PMID: 35243594, DOI: 10.1245/s10434-022-11383-w.
- Bakkila BF, Kerekes D, Nunez-Smith M, Billingsley KG, Ahuja N, Wang K, Oladele C, Johnson CH, Khan SA. Evaluation of Racial Disparities in Quality of Care for Patients With Gastrointestinal Tract Cancer Treated With Surgery. JAMA Network Open 2022, 5: e225664. PMID: 35377425, PMCID: PMC8980937, DOI: 10.1001/jamanetworkopen.2022.5664.
- Shen X, Cai Y, Lu L, Huang H, Yan H, Paty PB, Muca E, Ahuja N, Zhang Y, Johnson CH, Khan SA. Asparagine Metabolism in Tumors Is Linked to Poor Survival in Females with Colorectal Cancer: A Cohort Study. Metabolites 2022, 12 PMID: 35208238, PMCID: PMC8875032, DOI: 10.3390/metabo12020164.
- Hasan NM, Sharma A, Ruzgar NM, Deshpande H, Olino K, Khan S, Ahuja N. Epigenetic signatures differentiate uterine and soft tissue leiomyosarcoma. Oncotarget 2021, 12: 1566-1579. PMID: 34381562, PMCID: PMC8351604, DOI: 10.18632/oncotarget.28032.
- Shah MH, Goldner WS, Benson AB, Bergsland E, Blaszkowsky LS, Brock P, Chan J, Das S, Dickson PV, Fanta P, Giordano T, Halfdanarson TR, Halperin D, He J, Heaney A, Heslin MJ, Kandeel F, Kardan A, Khan SA, Kuvshinoff BW, Lieu C, Miller K, Pillarisetty VG, Reidy D, Salgado SA, Shaheen S, Soares HP, Soulen MC, Strosberg JR, Sussman CR, Trikalinos NA, Uboha NA, Vijayvergia N, Wong T, Lynn B, Hochstetler C. Neuroendocrine and Adrenal Tumors, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network : JNCCN 2021, 19: 839-868. PMID: 34340212, DOI: 10.6004/jnccn.2021.0032.
- Cai Y, Kim DJ, Takahashi T, Broadhurst DI, Yan H, Ma S, Rattray NJW, Casanovas-Massana A, Israelow B, Klein J, Lucas C, Mao T, Moore AJ, Muenker MC, Oh JE, Silva J, Wong P, Ko AI, Khan SA, Iwasaki A, Johnson CH. Kynurenic acid may underlie sex-specific immune responses to COVID-19. Science Signaling 2021, 14 PMID: 34230210, PMCID: PMC8432948, DOI: 10.1126/scisignal.abf8483.
- Zhu G, Su H, Johnson CH, Khan SA, Kluger H, Lu L. Intratumour microbiome associated with the infiltration of cytotoxic CD8+ T cells and patient survival in cutaneous melanoma. European Journal Of Cancer (Oxford, England : 1990) 2021, 151: 25-34. PMID: 33962358, PMCID: PMC8184628, DOI: 10.1016/j.ejca.2021.03.053.
- Tian J, Zhang D, Kurbatov V, Wang Q, Wang Y, Fang D, Wu L, Bosenberg M, Muzumdar MD, Khan S, Lu Q, Yan Q, Lu J. 5-Fluorouracil efficacy requires anti-tumor immunity triggered by cancer-cell-intrinsic STING. The EMBO Journal 2021, 40: e106065. PMID: 33615517, PMCID: PMC8013832, DOI: 10.15252/embj.2020106065.
- Miccio JA, Talcott WJ, Patel T, Park HS, Cecchini M, Salem RR, Khan SA, Stein S, Kortmansky JS, Lacy J, Narang A, Herman J, Jabbour SK, Hallemeier CL, Johung K, Jethwa KR. Margin negative resection and pathologic downstaging with multiagent chemotherapy with or without radiotherapy in patients with localized pancreas cancer: A national cancer database analysis. Clinical And Translational Radiation Oncology 2021, 27: 15-23. PMID: 33392398, PMCID: PMC7772693, DOI: 10.1016/j.ctro.2020.12.003.
- Cai Y, Kim DJ, Takahashi T, Broadhurst DI, Ma S, Rattray NJW, Casanovas-Massana A, Israelow B, Klein J, Lucas C, Mao T, Moore AJ, Muenker MC, Oh J, Silva J, Wong P, Ko AJ, Khan SA, Iwasaki A, Johnson CH. Kynurenic acid underlies sex-specific immune responses to COVID-19. MedRxiv : The Preprint Server For Health Sciences 2020 PMID: 32935119, PMCID: PMC7491534, DOI: 10.1101/2020.09.06.20189159.
- Liu S, Heller DR, Jean RA, Chiu AS, Khan SA, Dardik A. Palliative care is underutilized and affects healthcare costs in ruptured abdominal aortic aneurysms. Surgery 2020, 168: 234-236. PMID: 32139140, PMCID: PMC7748368, DOI: 10.1016/j.surg.2020.01.017.
- Cai Y, Rattray NJW, Zhang Q, Mironova V, Santos-Neto A, Muca E, Vollmar AKR, Hsu KS, Rattray Z, Cross JR, Zhang Y, Paty PB, Khan SA, Johnson CH. Tumor Tissue-Specific Biomarkers of Colorectal Cancer by Anatomic Location and Stage. Metabolites 2020, 10 PMID: 32575361, PMCID: PMC7345993, DOI: 10.3390/metabo10060257.
- Kurbatov V, Khan SA. Exploring Microsatellite Instability (MSI) in Colorectal Cancer at Elevated Microsatellite Alterations at Selected Tetranucleotides (EMAST). Annals Of Surgical Oncology 2020, 27: 973-974. PMID: 31788754, DOI: 10.1245/s10434-019-08051-x.
- Liu Z, Luo JJ, Pei KY, Khan SA, Wang XX, Zhao ZX, Yang M, Johnson CH, Wang XS, Zhang Y. Joint effect of pre-operative anemia and perioperative blood transfusion on outcomes of colon-cancer patients undergoing colectomy. Gastroenterology Report 2020, 8: 151-157. PMID: 32280475, PMCID: PMC7136710, DOI: 10.1093/gastro/goz033.
- Cai Y, Rattray NJW, Zhang Q, Mironova V, Santos-Neto A, Hsu KS, Rattray Z, Cross JR, Zhang Y, Paty PB, Khan SA, Johnson CH. Sex Differences in Colon Cancer Metabolism Reveal A Novel Subphenotype. Scientific Reports 2020, 10: 4905. PMID: 32184446, PMCID: PMC7078199, DOI: 10.1038/s41598-020-61851-0.
- Kurbatov V, Balayev A, Saffarzadeh A, Heller DR, Boffa DJ, Blasberg JD, Lu J, Khan SA. Digital Inference of Immune Microenvironment Reveals Low-Risk Subtype of Early Lung Adenocarcinoma. The Annals Of Thoracic Surgery 2020, 109: 343-349. PMID: 31568747, DOI: 10.1016/j.athoracsur.2019.08.050.
- Heller DR, Nicolson NG, Ahuja N, Khan S, Kunstman JW. Association of Treatment Inequity and Ancestry With Pancreatic Ductal Adenocarcinoma Survival. JAMA Surgery 2020, 155: e195047. PMID: 31800002, PMCID: PMC6902102, DOI: 10.1001/jamasurg.2019.5047.
- Kurbatov V, Resio BJ, Cama CA, Heller DR, Cha C, Zhang Y, Lu J, Khan SA. Liver-first approach to stage IV colon cancer with synchronous isolated liver metastases. Journal Of Gastrointestinal Oncology 2020, 11: 76-83. PMID: 32175108, PMCID: PMC7052756, DOI: 10.21037/jgo.2020.01.03.
- Sun Y, Mironova V, Chen Y, Lundh EPF, Zhang Q, Cai Y, Vasiliou V, Zhang Y, Garcia-Milian R, Khan SA, Johnson CH. Molecular Pathway Analysis Indicates a Distinct Metabolic Phenotype in Women With Right-Sided Colon Cancer. Translational Oncology 2020, 13: 42-56. PMID: 31760268, PMCID: PMC6883319, DOI: 10.1016/j.tranon.2019.09.004.
- Gene Alterations of N6-Methyladenosine (m6A) Regulators in Colorectal Cancer: A TCGA Database Study.Zhang Q, Cai Y, Kurbatov V, Khan SA, Lu L, Zhang Y, Johnson CH. Gene Alterations of N6-Methyladenosine (m6A) Regulators in Colorectal Cancer: A TCGA Database Study. BioMed Research International 2020, 2020: 8826456. PMID: 33415160, PMCID: PMC7769650, DOI: 10.1155/2020/8826456.
- Tang S, Liu F, Li Y, Zhao L, Wang X, Khan SA, Chen Y, Zhang Y. Treatment Selection and Survival Outcomes in Locally Advanced Proximal Gastric Cancer: A National Cancer Data Base Analysis. Frontiers In Oncology 2020, 10: 537051. PMID: 33102212, PMCID: PMC7546198, DOI: 10.3389/fonc.2020.537051.
- Uhlig J, Sellers CM, Khan SA, Cha C, Kim HS. Hepatocellular carcinoma: Impact of academic setting and hospital volume on patient survival. Surgical Oncology 2019, 31: 111-118. PMID: 31654956, DOI: 10.1016/j.suronc.2019.10.009.
- Heller DR, Jean RA, Khan SA. Appendiceal Carcinoid Tumors: In Reply to Sugarbaker. Journal Of The American College Of Surgeons 2019, 229: 519. PMID: 31655709, DOI: 10.1016/j.jamcollsurg.2019.07.005.
- Heller DR, Jean RA, Khan SA. Lymph Node Status: In Reply to Carr. Journal Of The American College Of Surgeons 2019, 229: 516-517. PMID: 31655706, DOI: 10.1016/j.jamcollsurg.2019.07.007.
- Miccio JA, Jairam V, Gao S, Augustyn A, Oladeru OT, Onderdonk BE, Chowdhary M, Han D, Khan S, Friedlaender G, Lindskog DM, Desphande HA, Osborn H, Roberts KB, Patel KR. Predictors of Lymph Node Involvement by Soft Tissue Sarcoma of the Trunk and Extremity: An Analysis of the National Cancer Database. Cure¯us 2019, 11: e6038. PMID: 31824805, PMCID: PMC6886621, DOI: 10.7759/cureus.6038.
- Luo J, Liu Z, Pei KY, Khan SA, Wang X, Yang M, Wang X, Zhang Y. The Role of Bowel Preparation in Open, Minimally Invasive, and Converted-to-Open Colectomy. The Journal Of Surgical Research 2019, 242: 183-192. PMID: 31085366, DOI: 10.1016/j.jss.2019.02.039.
- Rubinstein JC, Khan SA, Christison-Lagay ER, Cha C. APC Mutational Patterns in Gastric Adenocarcinoma are Enriched for Missense Variants with Associated Decreased Survival. Genes, Chromosomes & Cancer 2019 PMID: 31353684, DOI: 10.1002/gcc.22792.
- Klemen ND, Wang M, Feingold PL, Cooper K, Pavri SN, Han D, Detterbeck FC, Boffa DJ, Khan SA, Olino K, Clune J, Ariyan S, Salem RR, Weiss SA, Kluger HM, Sznol M, Cha C. Patterns of failure after immunotherapy with checkpoint inhibitors predict durable progression-free survival after local therapy for metastatic melanoma. Journal For Immunotherapy Of Cancer 2019, 7: 196. PMID: 31340861, PMCID: PMC6657062, DOI: 10.1186/s40425-019-0672-3.
- Uhlig J, Sellers CM, Cha C, Khan SA, Lacy J, Stein SM, Kim HS. Intrahepatic Cholangiocarcinoma: Socioeconomic Discrepancies, Contemporary Treatment Approaches and Survival Trends from the National Cancer Database. Annals Of Surgical Oncology 2019, 26: 1993-2000. PMID: 30693451, DOI: 10.1245/s10434-019-07175-4.
- Pavri SN, Han G, Khan S, Han D. Does sentinel lymph node status have prognostic significance in patients with acral lentiginous melanoma? Journal Of Surgical Oncology 2019, 119: 1060-1069. PMID: 30883783, DOI: 10.1002/jso.25445.
- Heller DR, Jean RA, Luo J, Kurbatov V, Grisotti G, Jacobs D, Chiu AS, Zhang Y, Khan SA. Practice Patterns and Guideline Non-Adherence in Surgical Management of Appendiceal Carcinoid Tumors. Journal Of The American College Of Surgeons 2019, 228: 839-851. PMID: 30898583, PMCID: PMC6751559, DOI: 10.1016/j.jamcollsurg.2019.02.050.
- How I Treat Gastric and Esophageal Cancer, Surgery.Khan SA, Kurbatov V, Posner MC. Handbook of Gastrointestinal Cancers: Evidence-Based Treatment and Multidisciplinary Patient Care 2019.
- Wang X, Liu F, Li Y, Tang S, Zhang Y, Chen Y, Khan SA. Comparison on Clinicopathological Features, Treatments and Prognosis between Proximal Gastric Cancer and Distal Gastric Cancer: A National Cancer Data Base Analysis. Journal Of Cancer 2019, 10: 3145-3153. PMID: 31289585, PMCID: PMC6603385, DOI: 10.7150/jca.30371.
- Heller DR, Jean RA, Chiu AS, Feder SI, Kurbatov V, Cha C, Khan SA. Regional Differences in Palliative Care Utilization Among Geriatric Colorectal Cancer Patients Needing Emergent Surgery. Journal Of Gastrointestinal Surgery : Official Journal Of The Society For Surgery Of The Alimentary Tract 2019, 23: 153-162. PMID: 30328071, PMCID: PMC6751557, DOI: 10.1007/s11605-018-3929-0.
- Blakaj A, Stein SM, Khan SA, Johung KL. Review and current state of radiation therapy for locally advanced pancreatic adenocarcinoma. Journal Of Gastrointestinal Oncology 2018, 9: 1027-1036. PMID: 30603121, PMCID: PMC6286948, DOI: 10.21037/jgo.2018.03.07.
- Pitroda SP, Khodarev NN, Huang L, Uppal A, Wightman SC, Ganai S, Joseph N, Pitt J, Brown M, Forde M, Mangold K, Xue L, Weber C, Segal JP, Kadri S, Stack ME, Khan S, Paty P, Kaul K, Andrade J, White KP, Talamonti M, Posner MC, Hellman S, Weichselbaum RR. Author Correction: Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis. Nature Communications 2018, 9: 4827. PMID: 30425251, PMCID: PMC6233186, DOI: 10.1038/s41467-018-07303-w.
- Shah MH, Goldner WS, Halfdanarson TR, Bergsland E, Berlin JD, Halperin D, Chan J, Kulke MH, Benson AB, Blaszkowsky LS, Eads J, Engstrom PF, Fanta P, Giordano T, He J, Heslin MJ, Kalemkerian GP, Kandeel F, Khan SA, Kidwai WZ, Kunz PL, Kuvshinoff BW, Lieu C, Pillarisetty VG, Saltz L, Sosa JA, Strosberg JR, Sussman CA, Trikalinos NA, Uboha NA, Whisenant J, Wong T, Yao JC, Burns JL, Ogba N, Zuccarino-Catania G. NCCN Guidelines Insights: Neuroendocrine and Adrenal Tumors, Version 2.2018. Journal Of The National Comprehensive Cancer Network : JNCCN 2018, 16: 693-702. PMID: 29891520, DOI: 10.6004/jnccn.2018.0056.
- Zhu R, Liu F, Grisotti G, Perez-Irizarry J, Salem RR, Cha CH, Johung KL, Boffa DJ, Zhang Y, Khan SA. Clinical impact of underutilization of adjuvant therapy in node positive gastric adenocarcinoma. Journal Of Gastrointestinal Oncology 2018, 9: 517-526. PMID: 29998017, PMCID: PMC6006033, DOI: 10.21037/jgo.2018.03.05.
- Pitroda SP, Khodarev NN, Huang L, Uppal A, Wightman SC, Ganai S, Joseph N, Pitt J, Brown M, Forde M, Mangold K, Xue L, Weber C, Segal JP, Kadri S, Stack ME, Khan S, Paty P, Kaul K, Andrade J, White KP, Talamonti M, Posner MC, Hellman S, Weichselbaum RR. Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis. Nature Communications 2018, 9: 1793. PMID: 29728604, PMCID: PMC5935683, DOI: 10.1038/s41467-018-04278-6.
- Zhu R, Liu F, Grisotti G, Pérez-Irizarry J, Cha CH, Johnson CH, Boffa DJ, Han D, Johung KL, Zhang Y, Khan SA. Distinctive features of gastrointestinal stromal tumors arising from the colon and rectum. Journal Of Gastrointestinal Oncology 2018, 9: 231-240. PMID: 29755761, PMCID: PMC5934147, DOI: 10.21037/jgo.2017.11.12.
- Rattray NJW, Deziel NC, Wallach JD, Khan SA, Vasiliou V, Ioannidis JPA, Johnson CH. Beyond genomics: understanding exposotypes through metabolomics. Human Genomics 2018, 12: 4. PMID: 29373992, PMCID: PMC5787293, DOI: 10.1186/s40246-018-0134-x.
- Jacobs D, Zhu R, Luo J, Grisotti G, Heller DR, Kurbatov V, Johnson CH, Zhang Y, Khan SA. Defining Early-Onset Colon and Rectal Cancers. Frontiers In Oncology 2018, 8: 504. PMID: 30460196, PMCID: PMC6232522, DOI: 10.3389/fonc.2018.00504.
- Gao SJ, Park HS, Corso CD, Rutter CE, Khan SA, Johung KL. Post-operative radiotherapy is associated with improved survival in esophageal cancer with positive surgical margins. Journal Of Gastrointestinal Oncology 2017, 8: 953-961. PMID: 29299354, PMCID: PMC5750177, DOI: 10.21037/jgo.2017.08.12.
- Pan W, Zhu S, Qu K, Meeth K, Cheng J, He K, Ma H, Liao Y, Wen X, Roden C, Tobiasova Z, Wei Z, Zhao J, Liu J, Zheng J, Guo B, Khan SA, Bosenberg M, Flavell RA, Lu J. The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression. Immunity 2017, 47: 284-297.e5. PMID: 28813659, PMCID: PMC5710009, DOI: 10.1016/j.immuni.2017.07.020.
- Khan SA, Zeng Z, Shia J, Paty PB. EGFR Gene Amplification and KRAS Mutation Predict Response to Combination Targeted Therapy in Metastatic Colorectal Cancer. Pathology Oncology Research : POR 2017, 23: 673-677. PMID: 28025786, PMCID: PMC5451302, DOI: 10.1007/s12253-016-0166-2.
- Rubinstein JC, Majumdar SK, Laskin W, Lazaga F, Prasad ML, Carling T, Khan SA. Hyperparathyroidism-Jaw Tumor Syndrome Associated With Large-Scale 1q31 Deletion. Journal Of The Endocrine Society 2017, 1: 926-930. PMID: 29264543, PMCID: PMC5686645, DOI: 10.1210/js.2016-1089.
- Liu J, Guo B, Chen Z, Wang N, Iacovino M, Cheng J, Roden C, Pan W, Khan S, Chen S, Kyba M, Fan R, Guo S, Lu J. miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism. Blood 2017, 129: 1491-1502. PMID: 28053194, PMCID: PMC5356452, DOI: 10.1182/blood-2016-06-721027.
- Kole AJ, Stahl JM, Park HS, Khan SA, Johung KL. Predictors of Nonadherence to NCCN Guideline Recommendations for the Management of Stage I Anal Canal Cancer. Journal Of The National Comprehensive Cancer Network : JNCCN 2017, 15: 355-362. PMID: 28275036, DOI: 10.6004/jnccn.2017.0035.
- Predictors of non-adherence to national comprehensive cancer network management guidelines for stage I anal canal cancerKole AJ, Stahl JM, Park HS, Khan SA, Johung KL. Predictors of non-adherence to national comprehensive cancer network management guidelines for stage I anal canal cancer. Journal of National Comprehensive Cancer Network 2017.
- Gastric volvulus after laparoscopic distal pancreatectomy and splenectomy: a case report of a rare post-operative complicationAlkukhun A, Grisotti G, Salem RR, Cha C, Khan SA. Gastric volvulus after laparoscopic distal pancreatectomy and splenectomy: a case report of a rare post-operative complication. In press at American College of Surgeons Case Reviews in Surgery 2017.
- Khan SA, Morris M, Idrees K, Gimbel MI, Rosenberg S, Zeng Z, Li F, Gan G, Shia J, LaQuaglia MP, Paty PB. Colorectal cancer in the very young: a comparative study of tumor markers, pathology and survival in early onset and adult onset patients. Journal Of Pediatric Surgery 2016, 51: 1812-1817. PMID: 27558481, PMCID: PMC5312708, DOI: 10.1016/j.jpedsurg.2016.07.015.
- Zhu R, Grisotti G, Salem RR, Khan SA. Pancreaticoduodenectomy for locally advanced colon cancer in hereditary nonpolyposis colorectal cancer. World Journal Of Surgical Oncology 2016, 14: 12. PMID: 26769110, PMCID: PMC4714509, DOI: 10.1186/s12957-015-0755-7.
- Wightman SC, Uppal A, Pitroda SP, Ganai S, Burnette B, Stack M, Oshima G, Khan S, Huang X, Posner MC, Weichselbaum RR, Khodarev NN. Oncogenic CXCL10 signalling drives metastasis development and poor clinical outcome. British Journal Of Cancer 2015, 113: 327-35. PMID: 26042934, PMCID: PMC4506383, DOI: 10.1038/bjc.2015.193.
- Management of Small Nonfunctional Pancreatic Neuroendocrine Tumor Molecular Cancer TherapeuticsGrisotti G, Khan SA. Management of Small Nonfunctional Pancreatic Neuroendocrine Tumor Molecular Cancer Therapeutics. Difficult Decisions in Hepatobiliary and Pancreatic Surgery – An Evidence Based Approach 2015
- Skin and Subcutaneous TissueKhan SA, Bank J, Choi E, Song D. Skin and Subcutaneous Tissue. Schwartz's Principles of Surgery, Tenth Edition, 2014.
- Khan SA, Matthews JB. Intraoperative margin re-resection for colorectal cancer liver metastases. Hepatobiliary Surgery And Nutrition 2013, 2: 108-12. PMID: 24570924, PMCID: PMC3924657, DOI: 10.3978/j.issn.2304-3881.2012.10.16.
- Pitroda SP, Zhou T, Sweis RF, Filippo M, Labay E, Beckett MA, Mauceri HJ, Liang H, Darga TE, Perakis S, Khan SA, Sutton HG, Zhang W, Khodarev NN, Garcia JG, Weichselbaum RR. Tumor endothelial inflammation predicts clinical outcome in diverse human cancers. PloS One 2012, 7: e46104. PMID: 23056240, PMCID: PMC3464251, DOI: 10.1371/journal.pone.0046104.
- Lussier YA, Khodarev NN, Regan K, Corbin K, Li H, Ganai S, Khan SA, Gnerlich JL, Darga TE, Fan H, Karpenko O, Paty PB, Posner MC, Chmura SJ, Hellman S, Ferguson MK, Weichselbaum RR. Oligo- and polymetastatic progression in lung metastasis(es) patients is associated with specific microRNAs. PloS One 2012, 7: e50141. PMID: 23251360, PMCID: PMC3518475, DOI: 10.1371/journal.pone.0050141.
- Owen RP, Khan SA, Negassa A, Beitler JJ, Bello JA, Brook A, Farinhas J, Garg MK, Haigentz M, Miller TS, Hsu MS, Ravikumar TS, Shifteh K, Smith RV, Silver CE. Radiofrequency ablation of advanced head and neck cancer. Archives Of Otolaryngology--head & Neck Surgery 2011, 137: 493-8. PMID: 21576561, DOI: 10.1001/archoto.2011.62.
- Lussier YA, Xing HR, Salama JK, Khodarev NN, Huang Y, Zhang Q, Khan SA, Yang X, Hasselle MD, Darga TE, Malik R, Fan H, Perakis S, Filippo M, Corbin K, Lee Y, Posner MC, Chmura SJ, Hellman S, Weichselbaum RR. MicroRNA expression characterizes oligometastasis(es). PloS One 2011, 6: e28650. PMID: 22174856, PMCID: PMC3236765, DOI: 10.1371/journal.pone.0028650.
- Esemuede I, Forslund A, Khan SA, Qin LX, Gimbel MI, Nash GM, Zeng Z, Rosenberg S, Shia J, Barany F, Paty PB. Improved testing for microsatellite instability in colorectal cancer using a simplified 3-marker assay. Annals Of Surgical Oncology 2010, 17: 3370-8. PMID: 20703819, PMCID: PMC3269820, DOI: 10.1245/s10434-010-1147-4.
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- Smilow Cancer Hospital Gastrointestinal Cancers ProgramTrumbull Care Center5520 Park AvenueTrumbull, CT 06611
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- Yale Surgical OncologySmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
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- Smilow Cancer Hospital Gastrointestinal Cancers ProgramTrumbull Care Center5520 Park AvenueTrumbull, CT 06611
- Smilow Cancer Hospital Melanoma ProgramTrumbull Care Center5520 Park AvenueTrumbull, CT 06611
- Yale Surgical OncologySmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
- Yale Surgical OncologyBridgeport Hospital267 Grant StreetBridgeport, CT 06610