Robert Homer, MD, PhD
Pathology, Thoracic Pathology, Anatomic Pathology
Biography
Robert Homer, MD, PhD, a pathologist, specializes in detecting diseases including cancers in and around the lungs. He is particularly interested in lung diseases leading to fibrosis, including those from exposures to foreign materials. He became interested in pathology as a graduate student—he wanted to know more about the structure and mechanisms of disease.
Dr. Homer is a professor of pathology at Yale School of Medicine.
Titles
- Professor of Pathology
- Director, Thoracic Pathology
- Director of Medical Studies
- Director, Medical Student Course Module
Education & Training
- ResidentYale-New Haven Hospital (1992)
- PhDYale University (1987)
- MDYale University (1987)
Additional Information
Honors & Recognitions
- Keynote address: Pulmonary Pathology Society (2009)
Board Certifications
- AB of Pathology, Anatomic Pathology (1991)
Professional Service
- Yale School of Medicine (2009 - 2012): Term Appointments and Promotion committee
Publications
- Baine MK, Febres-Aldana CA, Chang JC, Jungbluth AA, Sethi S, Antonescu CR, Travis WD, Hsieh MS, Roh MS, Homer RJ, Ladanyi M, Egger JV, Lai WV, Rudin CM, Rekhtman N. POU2F3 in SCLC: Clinicopathologic and Genomic Analysis With a Focus on Its Diagnostic Utility in Neuroendocrine-Low SCLC. Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer 2022, 17: 1109-1121. PMID: 35760287, PMCID: PMC9427708, DOI: 10.1016/j.jtho.2022.06.004.
- Fernández-Castañeda A, Lu P, Geraghty AC, Song E, Lee MH, Wood J, O'Dea MR, Dutton S, Shamardani K, Nwangwu K, Mancusi R, Yalçın B, Taylor KR, Acosta-Alvarez L, Malacon K, Keough MB, Ni L, Woo PJ, Contreras-Esquivel D, Toland AMS, Gehlhausen JR, Klein J, Takahashi T, Silva J, Israelow B, Lucas C, Mao T, Peña-Hernández MA, Tabachnikova A, Homer RJ, Tabacof L, Tosto-Mancuso J, Breyman E, Kontorovich A, McCarthy D, Quezado M, Vogel H, Hefti MM, Perl DP, Liddelow S, Folkerth R, Putrino D, Nath A, Iwasaki A, Monje M. Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation. Cell 2022, 185: 2452-2468.e16. PMID: 35768006, PMCID: PMC9189143, DOI: 10.1016/j.cell.2022.06.008.
- Shafi S, Aung TN, Robbins C, Zugazagoitia J, Vathiotis I, Gavrielatou N, Yaghoobi V, Fernandez A, Niu S, Liu LN, Cusumano ZT, Leelatian N, Cole K, Wang H, Homer R, Herbst RS, Langermann S, Rimm DL. Development of an immunohistochemical assay for Siglec-15. Laboratory Investigation; A Journal Of Technical Methods And Pathology 2022, 102: 771-778. PMID: 35459795, PMCID: PMC9253057, DOI: 10.1038/s41374-022-00785-9.
- Damsky W, Wang A, Kim DJ, Young BD, Singh K, Murphy MJ, Daccache J, Clark A, Ayasun R, Ryu C, McGeary MK, Odell ID, Fazzone-Chettiar R, Pucar D, Homer R, Gulati M, Miller EJ, Bosenberg M, Flavell RA, King B. Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis. Nature Communications 2022, 13: 3140. PMID: 35668129, PMCID: PMC9170782, DOI: 10.1038/s41467-022-30615-x.
- Suberi A, Grun MK, Mao T, Israelow B, Reschke M, Grundler J, Akhtar L, Lee T, Shin K, Piotrowski-Daspit AS, Homer RJ, Iwasaki A, Suh HW, Saltzman WM. Inhalable polymer nanoparticles for versatile mRNA delivery and mucosal vaccination. BioRxiv : The Preprint Server For Biology 2022 PMID: 35350207, PMCID: PMC8963702, DOI: 10.1101/2022.03.22.485401.
- Kulkarni HS, Lee JS, Bastarache JA, Kuebler WM, Downey GP, Albaiceta GM, Altemeier WA, Artigas A, Bates JHT, Calfee CS, Dela Cruz CS, Dickson RP, Englert JA, Everitt JI, Fessler MB, Gelman AE, Gowdy KM, Groshong SD, Herold S, Homer RJ, Horowitz JC, Hsia CCW, Kurahashi K, Laubach VE, Looney MR, Lucas R, Mangalmurti NS, Manicone AM, Martin TR, Matalon S, Matthay MA, McAuley DF, McGrath-Morrow SA, Mizgerd JP, Montgomery SA, Moore BB, Noël A, Perlman CE, Reilly JP, Schmidt EP, Skerrett SJ, Suber TL, Summers C, Suratt BT, Takata M, Tuder R, Uhlig S, Witzenrath M, Zemans RL, Matute-Bello G. Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report. American Journal Of Respiratory Cell And Molecular Biology 2022, 66: e1-e14. PMID: 35103557, PMCID: PMC8845128, DOI: 10.1165/rcmb.2021-0531ST.
- Mao T, Israelow B, Suberi A, Zhou L, Reschke M, Peña-Hernández MA, Dong H, Homer RJ, Saltzman WM, Iwasaki A. Unadjuvanted intranasal spike vaccine booster elicits robust protective mucosal immunity against sarbecoviruses. BioRxiv : The Preprint Server For Biology 2022 PMID: 35118464, PMCID: PMC8811895, DOI: 10.1101/2022.01.24.477597.
- Robles-Oteiza C, Ayeni D, Levy S, Homer RJ, Kaech SM, Politi K. Elevated murine HB-EGF confers sensitivity to diphtheria toxin in EGFR-mutant lung adenocarcinoma. Disease Models & Mechanisms 2021, 14 PMID: 34494649, PMCID: PMC8617309, DOI: 10.1242/dmm.049072.
- Schupp JC, Adams TS, Cosme C, Raredon MSB, Yuan Y, Omote N, Poli S, Chioccioli M, Rose KA, Manning EP, Sauler M, DeIuliis G, Ahangari F, Neumark N, Habermann AC, Gutierrez AJ, Bui LT, Lafyatis R, Pierce RW, Meyer KB, Nawijn MC, Teichmann SA, Banovich NE, Kropski JA, Niklason LE, Pe'er D, Yan X, Homer RJ, Rosas IO, Kaminski N. Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung. Circulation 2021, 144: 286-302. PMID: 34030460, PMCID: PMC8300155, DOI: 10.1161/CIRCULATIONAHA.120.052318.
- Foggetti G, Li C, Cai H, Hellyer JA, Lin WY, Ayeni D, Hastings K, Choi J, Wurtz A, Andrejka L, Maghini DG, Rashleigh N, Levy S, Homer R, Gettinger SN, Diehn M, Wakelee HA, Petrov DA, Winslow MM, Politi K. Genetic Determinants of EGFR-Driven Lung Cancer Growth and Therapeutic Response In Vivo. Cancer Discovery 2021, 11: 1736-1753. PMID: 33707235, PMCID: PMC8530463, DOI: 10.1158/2159-8290.CD-20-1385.
- Uhlig J, Mehta S, Case MD, Dhanasopon A, Blasberg J, Homer RJ, Solomon SB, Kim HS. Effectiveness of Thermal Ablation and Stereotactic Radiotherapy Based on Stage I Lung Cancer Histology. Journal Of Vascular And Interventional Radiology : JVIR 2021, 32: 1022-1028.e4. PMID: 33811997, DOI: 10.1016/j.jvir.2021.02.025.
- Camp R, Smith ML, Larsen BT, Roden AC, Farver C, Moreira AL, Attanoos R, Pillappa R, Sansano I, Fabro AT, Homer RJ. Reliability of histopathologic diagnosis of fibrotic interstitial lung disease: an international collaborative standardization project. BMC Pulmonary Medicine 2021, 21: 184. PMID: 34074264, PMCID: PMC8170950, DOI: 10.1186/s12890-021-01522-6.
- Torres R, Olson E, Homer R, Martin DT, Levene MJ, Perincheri S, Sprenkle PC, Humphrey PA. Initial Evaluation of Rapid, Direct-to-Digital Prostate Biopsy Pathology. Archives Of Pathology & Laboratory Medicine 2021, 145: 583-591. PMID: 32991670, DOI: 10.5858/arpa.2020-0037-OA.
- Gao R, Peng X, Perry C, Sun H, Ntokou A, Ryu C, Gomez JL, Reeves BC, Walia A, Kaminski N, Neumark N, Ishikawa G, Black KE, Hariri LP, Moore MW, Gulati M, Homer RJ, Greif DM, Eltzschig HK, Herzog EL. Macrophage-derived netrin-1 drives adrenergic nerve-associated lung fibrosis. The Journal Of Clinical Investigation 2021, 131 PMID: 33393489, PMCID: PMC7773383, DOI: 10.1172/JCI136542.
- Pednekar P, Amoah K, Homer R, Ryu C, Lutchmansingh DD. Case Report: Bullous Lung Disease Following COVID-19. Frontiers In Medicine 2021, 8: 770778. PMID: 34869488, PMCID: PMC8635639, DOI: 10.3389/fmed.2021.770778.
- Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer RJ, Ring A, Wilen CB, Iwasaki A. Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. The Journal Of Experimental Medicine 2020, 217 PMID: 32750141, PMCID: PMC7401025, DOI: 10.1084/jem.20201241.
- Jiang R, Hoehn KB, Lee CS, Pham MC, Homer RJ, Detterbeck FC, Aban I, Jacobson L, Vincent A, Nowak RJ, Kaminski HJ, Kleinstein SH, O'Connor KC. Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 30649-30660. PMID: 33199596, PMCID: PMC7720237, DOI: 10.1073/pnas.2007206117.
- Adams TS, Schupp JC, Poli S, Ayaub EA, Neumark N, Ahangari F, Chu SG, Raby BA, DeIuliis G, Januszyk M, Duan Q, Arnett HA, Siddiqui A, Washko GR, Homer R, Yan X, Rosas IO, Kaminski N. Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis. Science Advances 2020, 6: eaba1983. PMID: 32832599, PMCID: PMC7439502, DOI: 10.1126/sciadv.aba1983.
- Adams TS, Schupp JC, Poli S, Ayaub EA, Neumark N, Ahangari F, Chu SG, Raby BA, DeIuliis G, Januszyk M, Duan Q, Arnett HA, Siddiqui A, Washko GR, Homer R, Yan X, Rosas IO, Kaminski N. Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis. Science Advances 2020, 6 PMID: 32937511, DOI: 10.1126/sciadv.aba1983.
- Goldman-Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer R, Ring A, Wilen C, Iwasaki A. Mouse Model of SARS-CoV-2 Reveals Inflammatory Role of Type I Interferon Signaling. SSRN 2020, 3628297. PMID: 32714125, PMCID: PMC7366812, DOI: 10.2139/ssrn.3628297.
- Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer RJ, Ring A, Wilen CB, Iwasaki A. Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. BioRxiv : The Preprint Server For Biology 2020 PMID: 32577647, PMCID: PMC7302201, DOI: 10.1101/2020.05.27.118893.
- Starrett JH, Guernet AA, Cuomo ME, Poels KE, van Alderwerelt van Rosenburgh IK, Nagelberg A, Farnsworth D, Price KS, Khan H, Ashtekar KD, Gaefele M, Ayeni D, Stewart TF, Kuhlmann A, Kaech S, Unni AM, Homer R, Lockwood WW, Michor F, Goldberg SB, Lemmon MA, Smith PD, Cross DA, Politi K. Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations. Cancer Research 2020, 80: 2017-2030. PMID: 32193290, PMCID: PMC7392201, DOI: 10.1158/0008-5472.CAN-19-3819.
- Baine MK, Sinard JH, Cai G, Homer RJ. A Semiquantitative Scoring System May Allow Biopsy Diagnosis of Pulmonary Large Cell Neuroendocrine Carcinoma. American Journal Of Clinical Pathology 2020, 153: 165-174. PMID: 31593583, PMCID: PMC7571487, DOI: 10.1093/ajcp/aqz149.
- McDonough JE, Ahangari F, Li Q, Jain S, Verleden SE, Herazo-Maya J, Vukmirovic M, DeIuliis G, Tzouvelekis A, Tanabe N, Chu F, Yan X, Verschakelen J, Homer RJ, Manatakis DV, Zhang J, Ding J, Maes K, De Sadeleer L, Vos R, Neyrinck A, Benos PV, Bar-Joseph Z, Tantin D, Hogg JC, Vanaudenaerde BM, Wuyts WA, Kaminski N. Transcriptional regulatory model of fibrosis progression in the human lung. JCI Insight 2019, 4 PMID: 31600171, PMCID: PMC6948862, DOI: 10.1172/jci.insight.131597.
- Mazer BL, Homer RJ, Rimm DL. False-positive pathology: improving reproducibility with the next generation of pathologists. Laboratory Investigation; A Journal Of Technical Methods And Pathology 2019, 99: 1260-1265. PMID: 31019290, DOI: 10.1038/s41374-019-0257-2.
- Ayeni D, Miller B, Kuhlmann A, Ho PC, Robles-Oteiza C, Gaefele M, Levy S, de Miguel FJ, Perry C, Guan T, Krystal G, Lockwood W, Zelterman D, Homer R, Liu Z, Kaech S, Politi K. Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration of inflammatory immune cells in EGFR mutant lung tumors. Journal For Immunotherapy Of Cancer 2019, 7: 172. PMID: 31291990, PMCID: PMC6617639, DOI: 10.1186/s40425-019-0643-8.
- Rimm DL, Han G, Taube JM, Yi ES, Bridge JA, Flieder DB, Homer R, Roden AC, Hirsch FR, Wistuba II, Pusztai L. Reanalysis of the NCCN PD-L1 companion diagnostic assay study for lung cancer in the context of PD-L1 expression findings in triple-negative breast cancer. Breast Cancer Research : BCR 2019, 21: 72. PMID: 31196152, PMCID: PMC6567382, DOI: 10.1186/s13058-019-1156-6.
- Kudo E, Song E, Yockey LJ, Rakib T, Wong PW, Homer RJ, Iwasaki A. Low ambient humidity impairs barrier function and innate resistance against influenza infection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 10905-10910. PMID: 31085641, PMCID: PMC6561219, DOI: 10.1073/pnas.1902840116.
- Kelleher DW, Yaggi M, Homer R, Herzog EL, Ryu C. A rare presentation of pulmonary sarcoidosis as a solitary lung mass: a case report. Journal Of Medical Case Reports 2018, 12: 94. PMID: 29650028, PMCID: PMC5897926, DOI: 10.1186/s13256-018-1632-0.
- Yu G, Tzouvelekis A, Wang R, Herazo-Maya JD, Ibarra GH, Srivastava A, de Castro JPW, DeIuliis G, Ahangari F, Woolard T, Aurelien N, Arrojo E Drigo R, Gan Y, Graham M, Liu X, Homer RJ, Scanlan TS, Mannam P, Lee PJ, Herzog EL, Bianco AC, Kaminski N. Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function. Nature Medicine 2018, 24: 39-49. PMID: 29200204, PMCID: PMC5760280, DOI: 10.1038/nm.4447.
- Rimm DL, Han G, Taube JM, Yi ES, Bridge JA, Flieder DB, Homer R, West WW, Wu H, Roden AC, Fujimoto J, Yu H, Anders R, Kowalewski A, Rivard C, Rehman J, Batenchuk C, Burns V, Hirsch FR, Wistuba II. A Prospective, Multi-institutional, Pathologist-Based Assessment of 4 Immunohistochemistry Assays for PD-L1 Expression in Non-Small Cell Lung Cancer. JAMA Oncology 2017, 3: 1051-1058. PMID: 28278348, PMCID: PMC5650234, DOI: 10.1001/jamaoncol.2017.0013.
- Homer R, Lederer DJ. Diagnosing idiopathic pulmonary fibrosis without a lung biopsy: honeycombing not required. Thorax 2017, 72: 391-392. PMID: 28280234, DOI: 10.1136/thoraxjnl-2016-209831.
- Tzouvelekis A, Yu G, Lino Cardenas CL, Herazo-Maya JD, Wang R, Woolard T, Zhang Y, Sakamoto K, Lee H, Yi JS, DeIuliis G, Xylourgidis N, Ahangari F, Lee PJ, Aidinis V, Herzog EL, Homer R, Bennett AM, Kaminski N. SH2 Domain-Containing Phosphatase-2 Is a Novel Antifibrotic Regulator in Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2017, 195: 500-514. PMID: 27736153, PMCID: PMC5378419, DOI: 10.1164/rccm.201602-0329OC.
- Ryu C, Herzog EL, Pan H, Homer R, Gulati M. Upper Airway Obstruction Requiring Emergent Tracheostomy Secondary to Laryngeal Sarcoidosis: A Case Report. The American Journal Of Case Reports 2017, 18: 157-159. PMID: 28190872, PMCID: PMC5319306, DOI: 10.12659/ajcr.902231.
- Uraki R, Hwang J, Jurado KA, Householder S, Yockey LJ, Hastings AK, Homer RJ, Iwasaki A, Fikrig E. Zika virus causes testicular atrophy. Science Advances 2017, 3: e1602899. PMID: 28261663, PMCID: PMC5321463, DOI: 10.1126/sciadv.1602899.
- Vukmirovic M, Herazo-Maya JD, Blackmon J, Skodric-Trifunovic V, Jovanovic D, Pavlovic S, Stojsic J, Zeljkovic V, Yan X, Homer R, Stefanovic B, Kaminski N. Identification and validation of differentially expressed transcripts by RNA-sequencing of formalin-fixed, paraffin-embedded (FFPE) lung tissue from patients with Idiopathic Pulmonary Fibrosis. BMC Pulmonary Medicine 2017, 17: 15. PMID: 28081703, PMCID: PMC5228096, DOI: 10.1186/s12890-016-0356-4.
- Golestani R, Razavian M, Ye Y, Zhang J, Jung JJ, Toczek J, Gona K, Kim HY, Elias JA, Lee CG, Homer RJ, Sadeghi MM. Matrix Metalloproteinase-Targeted Imaging of Lung Inflammation and Remodeling. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2017, 58: 138-143. PMID: 27469361, PMCID: PMC5209638, DOI: 10.2967/jnumed.116.176198.
- Peng X, Moore M, Mathur A, Zhou Y, Sun H, Gan Y, Herazo-Maya JD, Kaminski N, Hu X, Pan H, Ryu C, Osafo-Addo A, Homer RJ, Feghali-Bostwick C, Fares W, Gulati M, Hu B, Lee CG, Elias JA, Herzog EL. Plexin C1 deficiency permits synaptotagmin 7-mediated macrophage migration and enhances mammalian lung fibrosis. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2016, 30: 4056-4070. PMID: 27609773, PMCID: PMC5102121, DOI: 10.1096/fj.201600373R.
- Sureshbabu A, Syed M, Das P, Janér C, Pryhuber G, Rahman A, Andersson S, Homer RJ, Bhandari V. Inhibition of Regulatory-Associated Protein of Mechanistic Target of Rapamycin Prevents Hyperoxia-Induced Lung Injury by Enhancing Autophagy and Reducing Apoptosis in Neonatal Mice. American Journal Of Respiratory Cell And Molecular Biology 2016, 55: 722-735. PMID: 27374190, PMCID: PMC5105179, DOI: 10.1165/rcmb.2015-0349OC.
- Rimm D, Han G, Taube JM, Yi ES, Bridge JA, Flieder DB, Homer R, West WW, Wu H, Roden AC, Fujimoto J, Yu H, Anders R, Kowalewski A, Rivard C, Rehman J, Hirsch F, Wistuba II. ORAL01.01: A Prospective, Multi-Institutional Assessment of Four Assays for PD-L1 Expression in NSCLC by Immunohistochemistry: Topic: Pathology. Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer 2016, 11: S249. PMID: 27969440, DOI: 10.1016/j.jtho.2016.09.006.
- Forloni M, Gupta R, Nagarajan A, Sun LS, Dong Y, Pirazzoli V, Toki M, Wurtz A, Melnick MA, Kobayashi S, Homer RJ, Rimm DL, Gettinger SJ, Politi K, Dogra SK, Wajapeyee N. Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells. Cell Reports 2016, 16: 457-471. PMID: 27346347, PMCID: PMC4945411, DOI: 10.1016/j.celrep.2016.05.087.
- Ryu C, Homer RJ, Herzog EL. The Airway in Idiopathic Pulmonary Fibrosis: Protecting the Lung or Promoting Disease? American Journal Of Respiratory And Critical Care Medicine 2016, 193: 1081-2. PMID: 27174477, PMCID: PMC4872674, DOI: 10.1164/rccm.201601-0055ED.
- Bramley K, Pisani MA, Murphy TE, Araujo KL, Homer RJ, Puchalski JT. Endobronchial Ultrasound-Guided Cautery-Assisted Transbronchial Forceps Biopsies: Safety and Sensitivity Relative to Transbronchial Needle Aspiration. The Annals Of Thoracic Surgery 2016, 101: 1870-6. PMID: 26912301, PMCID: PMC4861078, DOI: 10.1016/j.athoracsur.2015.11.051.
- Pillai PS, Molony RD, Martinod K, Dong H, Pang IK, Tal MC, Solis AG, Bielecki P, Mohanty S, Trentalange M, Homer RJ, Flavell RA, Wagner DD, Montgomery RR, Shaw AC, Staeheli P, Iwasaki A. Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease. Science (New York, N.Y.) 2016, 352: 463-6. PMID: 27102485, PMCID: PMC5465864, DOI: 10.1126/science.aaf3926.
- Bruscia E, Zhang PX, Barone C, Scholte B, Homer RJ, Krause D, Egan ME. Increased susceptibility of Cftr-/- mice to LPS-induced lung remodeling. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2016, 310: L711-9. PMID: 26851259, PMCID: PMC4836110, DOI: 10.1152/ajplung.00284.2015.
- Ramaswamy A, Homer R, Killam J, Pisani MA, Murphy TE, Araujo K, Puchalski J. Comparison of Transbronchial and Cryobiopsies in Evaluation of Diffuse Parenchymal Lung Disease. Journal Of Bronchology & Interventional Pulmonology 2016, 23: 14-21. PMID: 26705007, PMCID: PMC4864578, DOI: 10.1097/LBR.0000000000000246.
- Syed MA, Choo-Wing R, Homer RJ, Bhandari V. Role of Nitric Oxide Isoforms in Vascular and Alveolar Development and Lung Injury in Vascular Endothelial Growth Factor Overexpressing Neonatal Mice Lungs. PloS One 2016, 11: e0147588. PMID: 26799210, PMCID: PMC4723240, DOI: 10.1371/journal.pone.0147588.
- Kang MJ, Yoon CM, Kim BH, Lee CM, Zhou Y, Sauler M, Homer R, Dhamija A, Boffa D, West AP, Shadel GS, Ting JP, Tedrow JR, Kaminski N, Kim WJ, Lee CG, Oh YM, Elias JA. Suppression of NLRX1 in chronic obstructive pulmonary disease. The Journal Of Clinical Investigation 2015, 125: 2458-62. PMID: 25938787, PMCID: PMC4497738, DOI: 10.1172/JCI71747.
- Homer RJ. Pathologists' staging of multiple foci of lung cancer: poor concordance in absence of dramatic histologic or molecular differences. American Journal Of Clinical Pathology 2015, 143: 701-6. PMID: 25873504, DOI: 10.1309/AJCPNBWF55VGKOIW.
- Sureshbabu A, Syed MA, Boddupalli CS, Dhodapkar MV, Homer RJ, Minoo P, Bhandari V. Conditional overexpression of TGFβ1 promotes pulmonary inflammation, apoptosis and mortality via TGFβR2 in the developing mouse lung. Respiratory Research 2015, 16: 4. PMID: 25591994, PMCID: PMC4307226, DOI: 10.1186/s12931-014-0162-6.
- Lee N, You S, Shin MS, Lee WW, Kang KS, Kim SH, Kim WU, Homer RJ, Kang MJ, Montgomery RR, Dela Cruz CS, Shaw AC, Lee PJ, Chupp GL, Hwang D, Kang I. IL-6 receptor α defines effector memory CD8+ T cells producing Th2 cytokines and expanding in asthma. American Journal Of Respiratory And Critical Care Medicine 2014, 190: 1383-94. PMID: 25390970, PMCID: PMC4299645, DOI: 10.1164/rccm.201403-0601OC.
- Zhang X, Shan P, Homer R, Zhang Y, Petrache I, Mannam P, Lee PJ. Cathepsin E promotes pulmonary emphysema via mitochondrial fission. The American Journal Of Pathology 2014, 184: 2730-41. PMID: 25239563, PMCID: PMC4188869, DOI: 10.1016/j.ajpath.2014.06.017.
- Lafferty EI, Flaczyk A, Angers I, Homer R, d'Hennezel E, Malo D, Piccirillo CA, Vidal SM, Qureshi ST. An ENU-induced splicing mutation reveals a role for Unc93b1 in early immune cell activation following influenza A H1N1 infection. Genes And Immunity 2014, 15: 320-32. PMID: 24848930, PMCID: PMC4978536, DOI: 10.1038/gene.2014.22.
- Zhou Y, Peng H, Sun H, Peng X, Tang C, Gan Y, Chen X, Mathur A, Hu B, Slade MD, Montgomery RR, Shaw AC, Homer RJ, White ES, Lee CM, Moore MW, Gulati M, Lee CG, Elias JA, Herzog EL. Chitinase 3-like 1 suppresses injury and promotes fibroproliferative responses in Mammalian lung fibrosis. Science Translational Medicine 2014, 6: 240ra76. PMID: 24920662, PMCID: PMC4340473, DOI: 10.1126/scitranslmed.3007096.
- Peng X, Moore MW, Peng H, Sun H, Gan Y, Homer RJ, Herzog EL. CD4+CD25+FoxP3+ Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-β1 exposed murine lung. Frontiers In Pharmacology 2014, 5: 80. PMID: 24904415, PMCID: PMC4032896, DOI: 10.3389/fphar.2014.00080.
- Cai G, Wong R, Chhieng D, Levy GH, Gettinger SN, Herbst RS, Puchalski JT, Homer RJ, Hui P. Identification of EGFR mutation, KRAS mutation, and ALK gene rearrangement in cytological specimens of primary and metastatic lung adenocarcinoma. Cancer Cytopathology 2013, 121: 500-7. PMID: 23495083, DOI: 10.1002/cncy.21288.
- Jamieson AM, Pasman L, Yu S, Gamradt P, Homer RJ, Decker T, Medzhitov R. Role of tissue protection in lethal respiratory viral-bacterial coinfection. Science (New York, N.Y.) 2013, 340: 1230-4. PMID: 23618765, PMCID: PMC3933032, DOI: 10.1126/science.1233632.
- Choo-Wing R, Syed MA, Harijith A, Bowen B, Pryhuber G, Janér C, Andersson S, Homer RJ, Bhandari V. Hyperoxia and interferon-γ-induced injury in developing lungs occur via cyclooxygenase-2 and the endoplasmic reticulum stress-dependent pathway. American Journal Of Respiratory Cell And Molecular Biology 2013, 48: 749-57. PMID: 23470621, PMCID: PMC3727872, DOI: 10.1165/rcmb.2012-0381OC.
- Reilkoff RA, Peng H, Murray LA, Peng X, Russell T, Montgomery R, Feghali-Bostwick C, Shaw A, Homer RJ, Gulati M, Mathur A, Elias JA, Herzog EL. Semaphorin 7a+ regulatory T cells are associated with progressive idiopathic pulmonary fibrosis and are implicated in transforming growth factor-β1-induced pulmonary fibrosis. American Journal Of Respiratory And Critical Care Medicine 2013, 187: 180-8. PMID: 23220917, PMCID: PMC3570653, DOI: 10.1164/rccm.201206-1109OC.
- Cho WK, Lee CM, Kang MJ, Huang Y, Giordano FJ, Lee PJ, Trow TK, Homer RJ, Sessa WC, Elias JA, Lee CG. IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2013, 304: L112-24. PMID: 23125252, PMCID: PMC3543640, DOI: 10.1152/ajplung.00101.2012.
- Sun H, Choo-Wing R, Sureshbabu A, Fan J, Leng L, Yu S, Jiang D, Noble P, Homer RJ, Bucala R, Bhandari V. A critical regulatory role for macrophage migration inhibitory factor in hyperoxia-induced injury in the developing murine lung. PloS One 2013, 8: e60560. PMID: 23637753, PMCID: PMC3639272, DOI: 10.1371/journal.pone.0060560.
- Carroll SF, Lafferty EI, Flaczyk A, Fujiwara TM, Homer R, Morgan K, Loredo-Osti JC, Qureshi ST. Susceptibility to progressive Cryptococcus neoformans pulmonary infection is regulated by loci on mouse chromosomes 1 and 9. Infection And Immunity 2012, 80: 4167-76. PMID: 22988020, PMCID: PMC3497416, DOI: 10.1128/IAI.00417-12.
- Gifford AH, Matsuoka M, Ghoda LY, Homer RJ, Enelow RI. Chronic inflammation and lung fibrosis: pleotropic syndromes but limited distinct phenotypes. Mucosal Immunology 2012, 5: 480-4. PMID: 22806097, DOI: 10.1038/mi.2012.68.
- Bhandari V, Choo-Wing R, Harijith A, Sun H, Syed MA, Homer RJ, Elias JA. Increased hyperoxia-induced lung injury in nitric oxide synthase 2 null mice is mediated via angiopoietin 2. American Journal Of Respiratory Cell And Molecular Biology 2012, 46: 668-76. PMID: 22227562, PMCID: PMC3359903, DOI: 10.1165/rcmb.2011-0074OC.
- Anagnostou VK, Dimou AT, Botsis T, Killiam EJ, Gustavson MD, Homer RJ, Boffa D, Zolota V, Dougenis D, Tanoue L, Gettinger SN, Detterbeck FC, Syrigos KN, Bepler G, Rimm DL. Molecular classification of nonsmall cell lung cancer using a 4-protein quantitative assay. Cancer 2012, 118: 1607-18. PMID: 22009766, DOI: 10.1002/cncr.26450.
- Antin-Ozerkis D, Rubinowitz A, Evans J, Homer RJ, Matthay RA. Interstitial lung disease in the connective tissue diseases. Clinics In Chest Medicine 2012, 33: 123-49. PMID: 22365251, DOI: 10.1016/j.ccm.2012.01.004.
- Detterbeck FC, Homer RJ. Approach to the ground-glass nodule. Clinics In Chest Medicine 2011, 32: 799-810. PMID: 22054887, DOI: 10.1016/j.ccm.2011.08.002.
- Mitchell C, Provost K, Niu N, Homer R, Cohn L. IFN-γ acts on the airway epithelium to inhibit local and systemic pathology in allergic airway disease. Journal Of Immunology (Baltimore, Md. : 1950) 2011, 187: 3815-20. PMID: 21873527, PMCID: PMC3178669, DOI: 10.4049/jimmunol.1100436.
- Gan Y, Reilkoff R, Peng X, Russell T, Chen Q, Mathai SK, Homer R, Gulati M, Siner J, Elias J, Bucala R, Herzog E. Role of semaphorin 7a signaling in transforming growth factor β1-induced lung fibrosis and scleroderma-related interstitial lung disease. Arthritis And Rheumatism 2011, 63: 2484-94. PMID: 21484765, PMCID: PMC3651701, DOI: 10.1002/art.30386.
- Mijares LA, Wangdi T, Sokol C, Homer R, Medzhitov R, Kazmierczak BI. Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an IL-1-dependent pathway. Journal Of Immunology (Baltimore, Md. : 1950) 2011, 186: 7080-8. PMID: 21572023, PMCID: PMC3110630, DOI: 10.4049/jimmunol.1003687.
- Matsuura H, Hartl D, Kang MJ, Dela Cruz CS, Koller B, Chupp GL, Homer RJ, Zhou Y, Cho WK, Elias JA, Lee CG. Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema. American Journal Of Respiratory Cell And Molecular Biology 2011, 44: 777-86. PMID: 20656949, PMCID: PMC3135840, DOI: 10.1165/rcmb.2010-0081OC.
- Homer RJ, Elias JA, Lee CG, Herzog E. Modern concepts on the role of inflammation in pulmonary fibrosis. Archives Of Pathology & Laboratory Medicine 2011, 135: 780-8. PMID: 21631273, DOI: 10.5858/2010-0296-RA.1.
- Ma B, Dela Cruz CS, Hartl D, Kang MJ, Takyar S, Homer RJ, Lee CG, Elias JA. RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism. American Journal Of Respiratory And Critical Care Medicine 2011, 183: 1322-35. PMID: 21278304, PMCID: PMC3114061, DOI: 10.1164/rccm.201008-1276OC.
- Harijith A, Choo-Wing R, Cataltepe S, Yasumatsu R, Aghai ZH, Janér J, Andersson S, Homer RJ, Bhandari V. A role for matrix metalloproteinase 9 in IFNγ-mediated injury in developing lungs: relevance to bronchopulmonary dysplasia. American Journal Of Respiratory Cell And Molecular Biology 2011, 44: 621-30. PMID: 21216975, PMCID: PMC3095982, DOI: 10.1165/rcmb.2010-0058OC.
- Murray LA, Chen Q, Kramer MS, Hesson DP, Argentieri RL, Peng X, Gulati M, Homer RJ, Russell T, van Rooijen N, Elias JA, Hogaboam CM, Herzog EL. TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P. The International Journal Of Biochemistry & Cell Biology 2011, 43: 154-62. PMID: 21044893, DOI: 10.1016/j.biocel.2010.10.013.
- Wright PL, Yu J, Di YP, Homer RJ, Chupp G, Elias JA, Cohn L, Sessa WC. Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation. The Journal Of Experimental Medicine 2010, 207: 2595-607. PMID: 20975041, PMCID: PMC2989775, DOI: 10.1084/jem.20100786.
- Homer RJ, Herzog EL. Recent advances in pulmonary fibrosis: implications for scleroderma. Current Opinion In Rheumatology 2010, 22: 683-9. PMID: 20693906, DOI: 10.1097/BOR.0b013e32833ddcc9.
- Antin-Ozerkis D, Evans J, Rubinowitz A, Homer RJ, Matthay RA. Pulmonary manifestations of rheumatoid arthritis. Clinics In Chest Medicine 2010, 31: 451-78. PMID: 20692539, DOI: 10.1016/j.ccm.2010.04.003.
- Jiang D, Liang J, Campanella GS, Guo R, Yu S, Xie T, Liu N, Jung Y, Homer R, Meltzer EB, Li Y, Tager AM, Goetinck PF, Luster AD, Noble PW. Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4. The Journal Of Clinical Investigation 2010, 120: 2049-57. PMID: 20484822, PMCID: PMC2877927, DOI: 10.1172/JCI38644.
- Anagnostou VK, Lowery FJ, Zolota V, Tzelepi V, Gopinath A, Liceaga C, Panagopoulos N, Frangia K, Tanoue L, Boffa D, Gettinger S, Detterbeck F, Homer RJ, Dougenis D, Rimm DL, Syrigos KN. High expression of BCL-2 predicts favorable outcome in non-small cell lung cancer patients with non squamous histology. BMC Cancer 2010, 10: 186. PMID: 20459695, PMCID: PMC2875218, DOI: 10.1186/1471-2407-10-186.
- Trang P, Medina PP, Wiggins JF, Ruffino L, Kelnar K, Omotola M, Homer R, Brown D, Bader AG, Weidhaas JB, Slack FJ. Regression of murine lung tumors by the let-7 microRNA. Oncogene 2010, 29: 1580-7. PMID: 19966857, PMCID: PMC2841713, DOI: 10.1038/onc.2009.445.
- Mathai SK, Rubinowitz AN, Homer RJ, Detterbeck F, Herzog EL. Of lungs, lipids, and lollipops. Chest 2009, 136: 1420-1423. PMID: 19892683, DOI: 10.1378/chest.08-2133.
- Niu N, Laufer T, Homer RJ, Cohn L. Cutting edge: Limiting MHC class II expression to dendritic cells alters the ability to develop Th2- dependent allergic airway inflammation. Journal Of Immunology (Baltimore, Md. : 1950) 2009, 183: 1523-7. PMID: 19596982, DOI: 10.4049/jimmunol.0901349.
- Anagnostou VK, Bepler G, Syrigos KN, Tanoue L, Gettinger S, Homer RJ, Boffa D, Detterbeck F, Rimm DL. High expression of mammalian target of rapamycin is associated with better outcome for patients with early stage lung adenocarcinoma. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2009, 15: 4157-64. PMID: 19509151, DOI: 10.1158/1078-0432.CCR-09-0099.
- Caceres AI, Brackmann M, Elia MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM, Jordt SE. A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 9099-104. PMID: 19458046, PMCID: PMC2684498, DOI: 10.1073/pnas.0900591106.
- Trow TK, Morris DG, Miller CR, Homer RJ. Granulomatous bronchiolitis of Crohn's disease successfully treated with inhaled budesonide. Thorax 2009, 64: 546-7. PMID: 19478123, DOI: 10.1136/thx.2008.107185.
- Lee CG, Hartl D, Lee GR, Koller B, Matsuura H, Da Silva CA, Sohn MH, Cohn L, Homer RJ, Kozhich AA, Humbles A, Kearley J, Coyle A, Chupp G, Reed J, Flavell RA, Elias JA. Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. The Journal Of Experimental Medicine 2009, 206: 1149-66. PMID: 19414556, PMCID: PMC2715037, DOI: 10.1084/jem.20081271.
- Oh SY, Zheng T, Kim YK, Cohn L, Homer RJ, McKenzie AN, Zhu Z. A critical role of SHP-1 in regulation of type 2 inflammation in the lung. American Journal Of Respiratory Cell And Molecular Biology 2009, 40: 568-74. PMID: 18952567, PMCID: PMC2677436, DOI: 10.1165/rcmb.2008-0225OC.
- Anagnostou VK, Syrigos KN, Bepler G, Homer RJ, Rimm DL. Thyroid transcription factor 1 is an independent prognostic factor for patients with stage I lung adenocarcinoma. Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology 2009, 27: 271-8. PMID: 19064983, DOI: 10.1200/JCO.2008.17.0043.
- Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production.Lee CG, Hartl D, Matsuura H, Dunlop FM, Scotney PD, Fabri LJ, Nash AD, Chen NY, Tang CY, Chen Q, Homer RJ, Baca M, Elias JA. Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production. American Journal Of Respiratory Cell And Molecular Biology 2008, 39: 739-46. PMID: 18617680, PMCID: PMC2586049, DOI: 10.1165/rcmb.2008-0053OC.
- Hartl D, He CH, Koller B, Da Silva CA, Homer R, Lee CG, Elias JA. Acidic mammalian chitinase is secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by pulmonary epithelial cells. The Journal Of Biological Chemistry 2008, 283: 33472-82. PMID: 18824549, PMCID: PMC2586247, DOI: 10.1074/jbc.M805574200.
- Chin LJ, Ratner E, Leng S, Zhai R, Nallur S, Babar I, Muller RU, Straka E, Su L, Burki EA, Crowell RE, Patel R, Kulkarni T, Homer R, Zelterman D, Kidd KK, Zhu Y, Christiani DC, Belinsky SA, Slack FJ, Weidhaas JB. A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. Cancer Research 2008, 68: 8535-40. PMID: 18922928, PMCID: PMC2672193, DOI: 10.1158/0008-5472.CAN-08-2129.
- Bhandari V, Choo-Wing R, Lee CG, Yusuf K, Nedrelow JH, Ambalavanan N, Malkus H, Homer RJ, Elias JA. Developmental regulation of NO-mediated VEGF-induced effects in the lung. American Journal Of Respiratory Cell And Molecular Biology 2008, 39: 420-30. PMID: 18441284, PMCID: PMC2551703, DOI: 10.1165/rcmb.2007-0024OC.
- Guillot L, Carroll SF, Homer R, Qureshi ST. Enhanced innate immune responsiveness to pulmonary Cryptococcus neoformans infection is associated with resistance to progressive infection. Infection And Immunity 2008, 76: 4745-56. PMID: 18678664, PMCID: PMC2546841, DOI: 10.1128/IAI.00341-08.
- Rubinowitz AN, Moon M, Homer R. A 34-year-old man presenting with gradual onset of shortness of breath and interstitial lung disease. Chest 2008, 133: 1041-7. PMID: 18398129, DOI: 10.1378/chest.07-2235.
- Yamasaki M, Kang HR, Homer RJ, Chapoval SP, Cho SJ, Lee BJ, Elias JA, Lee CG. P21 regulates TGF-beta1-induced pulmonary responses via a TNF-alpha-signaling pathway. American Journal Of Respiratory Cell And Molecular Biology 2008, 38: 346-53. PMID: 17932374, PMCID: PMC2258454, DOI: 10.1165/rcmb.2007-0276OC.
- Zhou J, Matsuoka M, Cantor H, Homer R, Enelow RI. Cutting edge: engagement of NKG2A on CD8+ effector T cells limits immunopathology in influenza pneumonia. Journal Of Immunology (Baltimore, Md. : 1950) 2008, 180: 25-9. PMID: 18096998, DOI: 10.4049/jimmunol.180.1.25.
- Zheng T, Liu W, Oh SY, Zhu Z, Hu B, Homer RJ, Cohn L, Grusby MJ, Elias JA. IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung. Journal Of Immunology (Baltimore, Md. : 1950) 2008, 180: 522-9. PMID: 18097054, DOI: 10.4049/jimmunol.180.1.522.
- Chapoval SP, Al-Garawi A, Lora JM, Strickland I, Ma B, Lee PJ, Homer RJ, Ghosh S, Coyle AJ, Elias JA. Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 179: 7030-41. PMID: 17982094, DOI: 10.4049/jimmunol.179.10.7030.
- Kenney B, Dotto J, Homer R, Shafi N, Davydova L. Primary malignant melanoma of the transverse colon: report of a case and review of the literature. International Journal Of Surgical Pathology 2007, 15: 401-7. PMID: 17913951, DOI: 10.1177/1066896907302370.
- Homer RJ. Airway remodeling and RELM-beta. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2007, 293: L303-4. PMID: 17586697, DOI: 10.1152/ajplung.00226.2007.
- Choo-Wing R, Nedrelow JH, Homer RJ, Elias JA, Bhandari V. Developmental differences in the responses of IL-6 and IL-13 transgenic mice exposed to hyperoxia. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2007, 293: L142-50. PMID: 17400600, DOI: 10.1152/ajplung.00434.2006.
- Kenney B, Pinto M, Homer R. Benign pulmonary epithelial inclusions within the pleura: a case report. Diagnostic Pathology 2007, 2: 21. PMID: 17603877, PMCID: PMC1914110, DOI: 10.1186/1746-1596-2-21.
- Simeone-Penney MC, Severgnini M, Tu P, Homer RJ, Mariani TJ, Cohn L, Simon AR. Airway epithelial STAT3 is required for allergic inflammation in a murine model of asthma. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 178: 6191-9. PMID: 17475846, DOI: 10.4049/jimmunol.178.10.6191.
- Kang HR, Lee CG, Homer RJ, Elias JA. Semaphorin 7A plays a critical role in TGF-beta1-induced pulmonary fibrosis. The Journal Of Experimental Medicine 2007, 204: 1083-93. PMID: 17485510, PMCID: PMC2118575, DOI: 10.1084/jem.20061273.
- Bhandari V, Choo-Wing R, Homer RJ, Elias JA. Increased hyperoxia-induced mortality and acute lung injury in IL-13 null mice. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 178: 4993-5000. PMID: 17404281, DOI: 10.4049/jimmunol.178.8.4993.
- Grigoriyan A, Rishi A, Molina J, Homer R, Manthous CA. Diffuse alveolar damage and hemorrhage in acute myelogenous leukemia treated with corticosteroids. Connecticut Medicine 2007, 71: 201-4. PMID: 17487004.
- Niu N, Le Goff MK, Li F, Rahman M, Homer RJ, Cohn L. A novel pathway that regulates inflammatory disease in the respiratory tract. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 178: 3846-55. PMID: 17339484, DOI: 10.4049/jimmunol.178.6.3846.
- Kang HR, Cho SJ, Lee CG, Homer RJ, Elias JA. Transforming growth factor (TGF)-beta1 stimulates pulmonary fibrosis and inflammation via a Bax-dependent, bid-activated pathway that involves matrix metalloproteinase-12. The Journal Of Biological Chemistry 2007, 282: 7723-32. PMID: 17209037, DOI: 10.1074/jbc.M610764200.
- Kang MJ, Homer RJ, Gallo A, Lee CG, Crothers KA, Cho SJ, Rochester C, Cain H, Chupp G, Yoon HJ, Elias JA. IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 178: 1948-59. PMID: 17237446, DOI: 10.4049/jimmunol.178.3.1948.
- Temann UA, Laouar Y, Eynon EE, Homer R, Flavell RA. IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells. International Immunology 2007, 19: 1-10. PMID: 17101709, DOI: 10.1093/intimm/dxl117.
- Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA. Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nature Medicine 2006, 12: 1286-93. PMID: 17086189, PMCID: PMC2768268, DOI: 10.1038/nm1494.
- Khazeni N, Homer RJ, Rubinowitz AN, Chupp GL. Massive cavitary pulmonary rheumatoid nodules in a patient with HIV. The European Respiratory Journal 2006, 28: 872-4. PMID: 17012633, DOI: 10.1183/09031936.06.00144105.
- Homer RJ, Zhu Z, Cohn L, Lee CG, White WI, Chen S, Elias JA. Differential expression of chitinases identify subsets of murine airway epithelial cells in allergic inflammation. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2006, 291: L502-11. PMID: 16556727, DOI: 10.1152/ajplung.00364.2005.
- Elias JA, Kang MJ, Crothers K, Homer R, Lee CG. State of the art. Mechanistic heterogeneity in chronic obstructive pulmonary disease: insights from transgenic mice. Proceedings Of The American Thoracic Society 2006, 3: 494-8. PMID: 16921126, DOI: 10.1513/pats.200603-068MS.
- Lee CG, Cho S, Homer RJ, Elias JA. Genetic control of transforming growth factor-beta1-induced emphysema and fibrosis in the murine lung. Proceedings Of The American Thoracic Society 2006, 3: 476-477. PMID: 16921114, DOI: 10.1513/pats.200603-040MS.
- Kang MJ, Lee CG, Cho SJ, Homer RJ, Elias JA. IFN-gamma-dependent DNA injury and/or apoptosis are critical in cigarette smoke-induced murine emphysema. Proceedings Of The American Thoracic Society 2006, 3: 517-8. PMID: 16921135, DOI: 10.1513/pats.200603-075MS.
- Shim YM, Zhu Z, Zheng T, Lee CG, Homer RJ, Ma B, Elias JA. Role of 5-lipoxygenase in IL-13-induced pulmonary inflammation and remodeling. Journal Of Immunology (Baltimore, Md. : 1950) 2006, 177: 1918-24. PMID: 16849505, DOI: 10.4049/jimmunol.177.3.1918.
- Bhandari V, Choo-Wing R, Chapoval SP, Lee CG, Tang C, Kim YK, Ma B, Baluk P, Lin MI, McDonald DM, Homer RJ, Sessa WC, Elias JA. Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 11021-6. PMID: 16832062, PMCID: PMC1544167, DOI: 10.1073/pnas.0601057103.
- Lee CG, Kang HR, Homer RJ, Chupp G, Elias JA. Transgenic modeling of transforming growth factor-beta(1): role of apoptosis in fibrosis and alveolar remodeling. Proceedings Of The American Thoracic Society 2006, 3: 418-23. PMID: 16799085, PMCID: PMC2658706, DOI: 10.1513/pats.200602-017AW.
- Ma B, Blackburn MR, Lee CG, Homer RJ, Liu W, Flavell RA, Boyden L, Lifton RP, Sun CX, Young HW, Elias JA. Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis. The Journal Of Clinical Investigation 2006, 116: 1274-83. PMID: 16670768, PMCID: PMC1451205, DOI: 10.1172/JCI26372.
- Ma B, Liu W, Homer RJ, Lee PJ, Coyle AJ, Lora JM, Lee CG, Elias JA. Role of CCR5 in the pathogenesis of IL-13-induced inflammation and remodeling. Journal Of Immunology (Baltimore, Md. : 1950) 2006, 176: 4968-78. PMID: 16585593, DOI: 10.4049/jimmunol.176.8.4968.
- Cho SJ, Kang MJ, Homer RJ, Kang HR, Zhang X, Lee PJ, Elias JA, Lee CG. Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling. The Journal Of Biological Chemistry 2006, 281: 8161-8. PMID: 16439363, DOI: 10.1074/jbc.M506770200.
- Lee PJ, Zhang X, Shan P, Ma B, Lee CG, Homer RJ, Zhu Z, Rincon M, Mossman BT, Elias JA. ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. The Journal Of Clinical Investigation 2006, 116: 163-73. PMID: 16374521, PMCID: PMC1319220, DOI: 10.1172/JCI25711.
- Ma B, Kang MJ, Lee CG, Chapoval S, Liu W, Chen Q, Coyle AJ, Lora JM, Picarella D, Homer RJ, Elias JA. Role of CCR5 in IFN-gamma-induced and cigarette smoke-induced emphysema. The Journal Of Clinical Investigation 2005, 115: 3460-72. PMID: 16284650, PMCID: PMC1280966, DOI: 10.1172/JCI24858.
- Noble PW, Tanoue L, Homer R. Case study review. Chest 2005, 128: 540S-546S. PMID: 16304245, DOI: 10.1378/chest.128.5_suppl_1.540S.
- Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y, Prestwich GD, Mascarenhas MM, Garg HG, Quinn DA, Homer RJ, Goldstein DR, Bucala R, Lee PJ, Medzhitov R, Noble PW. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nature Medicine 2005, 11: 1173-9. PMID: 16244651, DOI: 10.1038/nm1315.
- Zhang X, Shan P, Qureshi S, Homer R, Medzhitov R, Noble PW, Lee PJ. Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury. Journal Of Immunology (Baltimore, Md. : 1950) 2005, 175: 4834-8. PMID: 16210584, DOI: 10.4049/jimmunol.175.8.4834.
- Elias JA, Homer RJ, Hamid Q, Lee CG. Chitinases and chitinase-like proteins in T(H)2 inflammation and asthma. The Journal Of Allergy And Clinical Immunology 2005, 116: 497-500. PMID: 16159614, DOI: 10.1016/j.jaci.2005.06.028.
- Noble PW, Homer RJ. Back to the future: historical perspective on the pathogenesis of idiopathic pulmonary fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2005, 33: 113-20. PMID: 16024580, DOI: 10.1165/rcmb.F301.
- Zheng T, Kang MJ, Crothers K, Zhu Z, Liu W, Lee CG, Rabach LA, Chapman HA, Homer RJ, Aldous D, De Sanctis GT, Underwood S, Graupe M, Flavell RA, Schmidt JA, Elias JA. Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema. Journal Of Immunology (Baltimore, Md. : 1950) 2005, 174: 8106-15. PMID: 15944319, DOI: 10.4049/jimmunol.174.12.8106.
- Inhibition of the Src and Jak kinases protects against lipopolysaccharide-induced acute lung injury.Severgnini M, Takahashi S, Tu P, Perides G, Homer RJ, Jhung JW, Bhavsar D, Cochran BH, Simon AR. Inhibition of the Src and Jak kinases protects against lipopolysaccharide-induced acute lung injury. American Journal Of Respiratory And Critical Care Medicine 2005, 171: 858-67. PMID: 15665321, DOI: 10.1164/rccm.200407-981OC.
- He CH, Waxman AB, Lee CG, Link H, Rabach ME, Ma B, Chen Q, Zhu Z, Zhong M, Nakayama K, Nakayama KI, Homer R, Elias JA. Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury. The Journal Of Clinical Investigation 2005, 115: 1039-48. PMID: 15841185, PMCID: PMC1070412, DOI: 10.1172/JCI23004.
- Chen Q, Rabach L, Noble P, Zheng T, Lee CG, Homer RJ, Elias JA. IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling. Journal Of Immunology (Baltimore, Md. : 1950) 2005, 174: 2305-13. PMID: 15699166, DOI: 10.4049/jimmunol.174.4.2305.
- Homer RJ, Elias JA. Airway remodeling in asthma: therapeutic implications of mechanisms. Physiology (Bethesda, Md.) 2005, 20: 28-35. PMID: 15653837, DOI: 10.1152/physiol.00035.2004.
- Noble PW, Homer RJ. Idiopathic pulmonary fibrosis: new insights into pathogenesis. Clinics In Chest Medicine 2004, 25: 749-58, vii. PMID: 15564020, DOI: 10.1016/j.ccm.2004.04.003.
- Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, Bhandari V, Kang MJ, Cohn L, Kim YK, McDonald DM, Elias JA. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nature Medicine 2004, 10: 1095-103. PMID: 15378055, PMCID: PMC3434232, DOI: 10.1038/nm1105.
- Kawikova I, Paliwal V, Szczepanik M, Itakura A, Fukui M, Campos RA, Geba GP, Homer RJ, Iliopoulou BP, Pober JS, Tsuji RF, Askenase PW. Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma. Immunology 2004, 113: 234-45. PMID: 15379984, PMCID: PMC1782564, DOI: 10.1111/j.1365-2567.2004.01936.x.
- Lee CG, Cho SJ, Kang MJ, Chapoval SP, Lee PJ, Noble PW, Yehualaeshet T, Lu B, Flavell RA, Milbrandt J, Homer RJ, Elias JA. Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. The Journal Of Experimental Medicine 2004, 200: 377-89. PMID: 15289506, PMCID: PMC2211975, DOI: 10.1084/jem.20040104.
- Jiang D, Liang J, Hodge J, Lu B, Zhu Z, Yu S, Fan J, Gao Y, Yin Z, Homer R, Gerard C, Noble PW. Regulation of pulmonary fibrosis by chemokine receptor CXCR3. The Journal Of Clinical Investigation 2004, 114: 291-9. PMID: 15254596, PMCID: PMC449741, DOI: 10.1172/JCI16861.
- Zhu Z, Zheng T, Homer RJ, Kim YK, Chen NY, Cohn L, Hamid Q, Elias JA. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science (New York, N.Y.) 2004, 304: 1678-82. PMID: 15192232, DOI: 10.1126/science.1095336.
- Severgnini M, Takahashi S, Rozo LM, Homer RJ, Kuhn C, Jhung JW, Perides G, Steer M, Hassoun PM, Fanburg BL, Cochran BH, Simon AR. Activation of the STAT pathway in acute lung injury. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2004, 286: L1282-92. PMID: 14729509, DOI: 10.1152/ajplung.00349.2003.
- Ma B, Zhu Z, Homer RJ, Gerard C, Strieter R, Elias JA. The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling. Journal Of Immunology (Baltimore, Md. : 1950) 2004, 172: 1872-81. PMID: 14734772, DOI: 10.4049/jimmunol.172.3.1872.
- Wang J, Chen Q, Corne J, Zhu Z, Lee CG, Bhandari V, Homer RJ, Elias JA. Pulmonary expression of leukemia inhibitory factor induces B cell hyperplasia and confers protection in hyperoxia. The Journal Of Biological Chemistry 2003, 278: 31226-32. PMID: 12782633, DOI: 10.1074/jbc.M301820200.
- Zheng T, Zhu Z, Liu W, Lee CG, Chen Q, Homer RJ, Elias JA. Cytokine regulation of IL-13Ralpha2 and IL-13Ralpha1 in vivo and in vitro. The Journal Of Allergy And Clinical Immunology 2003, 111: 720-8. PMID: 12704349, DOI: 10.1067/mai.2003.1383.
- Zhu Z, Enhorning G, Zheng T, Chen Q, Chen NY, Homer R, Elias JA. Interleukin-13 induces surfactant function abnormality in the murine lung. Chest 2003, 123: 375S-6S. PMID: 12628990.
- Elias JA, Zheng T, Lee CG, Homer RJ, Chen Q, Ma B, Blackburn M, Zhu Z. Transgenic modeling of interleukin-13 in the lung. Chest 2003, 123: 339S-45S. PMID: 12628967.
- Elias JA, Lee CG, Zheng T, Ma B, Homer RJ, Zhu Z. New insights into the pathogenesis of asthma. The Journal Of Clinical Investigation 2003, 111: 291-7. PMID: 12569150, PMCID: PMC151878, DOI: 10.1172/JCI17748.
- Whittaker L, Niu N, Temann UA, Stoddard A, Flavell RA, Ray A, Homer RJ, Cohn L. Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9. American Journal Of Respiratory Cell And Molecular Biology 2002, 27: 593-602. PMID: 12397019, DOI: 10.1165/rcmb.4838.
- Lee CG, Homer RJ, Cohn L, Link H, Jung S, Craft JE, Graham BS, Johnson TR, Elias JA. Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways. The Journal Of Biological Chemistry 2002, 277: 35466-74. PMID: 12107190, DOI: 10.1074/jbc.M206395200.
- Lanone S, Zheng T, Zhu Z, Liu W, Lee CG, Ma B, Chen Q, Homer RJ, Wang J, Rabach LA, Rabach ME, Shipley JM, Shapiro SD, Senior RM, Elias JA. Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling. The Journal Of Clinical Investigation 2002, 110: 463-74. PMID: 12189240, PMCID: PMC150413, DOI: 10.1172/JCI14136.
- Homer RJ, Zheng T, Chupp G, He S, Zhu Z, Chen Q, Ma B, Hite RD, Gobran LI, Rooney SA, Elias JA. Pulmonary type II cell hypertrophy and pulmonary lipoproteinosis are features of chronic IL-13 exposure. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2002, 283: L52-9. PMID: 12060560, DOI: 10.1152/ajplung.00438.2001.
- Zhu Z, Zheng T, Lee CG, Homer RJ, Elias JA. Tetracycline-controlled transcriptional regulation systems: advances and application in transgenic animal modeling. Seminars In Cell & Developmental Biology 2002, 13: 121-8. PMID: 12127145, DOI: 10.1016/s1084-9521(02)00018-6.
- Zhu Z, Ma B, Zheng T, Homer RJ, Lee CG, Charo IF, Noble P, Elias JA. IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling. Journal Of Immunology (Baltimore, Md. : 1950) 2002, 168: 2953-62. PMID: 11884467, DOI: 10.4049/jimmunol.168.6.2953.
- Cohn L, Whittaker L, Niu N, Homer RJ. Cytokine regulation of mucus production in a model of allergic asthma. Novartis Foundation Symposium 2002, 248: 201-13; discussion 213-20, 277-82. PMID: 12568496.
- Zhu Z, Lee CG, Zheng T, Chupp G, Wang J, Homer RJ, Noble PW, Hamid Q, Elias JA. Airway inflammation and remodeling in asthma. Lessons from interleukin 11 and interleukin 13 transgenic mice. American Journal Of Respiratory And Critical Care Medicine 2001, 164: S67-70. PMID: 11734470, DOI: 10.1164/ajrccm.164.supplement_2.2106070.
- Zheng T, Zhu Z, Wang J, Homer RJ, Elias JA. IL-11: insights in asthma from overexpression transgenic modeling. The Journal Of Allergy And Clinical Immunology 2001, 108: 489-96. PMID: 11590369, DOI: 10.1067/mai.2001.118510.
- Lee CG, Homer RJ, Zhu Z, Lanone S, Wang X, Koteliansky V, Shipley JM, Gotwals P, Noble P, Chen Q, Senior RM, Elias JA. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). The Journal Of Experimental Medicine 2001, 194: 809-21. PMID: 11560996, PMCID: PMC2195954, DOI: 10.1084/jem.194.6.809.
- Zhu Z, Ma B, Homer RJ, Zheng T, Elias JA. Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice. The Journal Of Biological Chemistry 2001, 276: 25222-9. PMID: 11331286, DOI: 10.1074/jbc.M101512200.
- Cohn L, Herrick C, Niu N, Homer R, Bottomly K. IL-4 promotes airway eosinophilia by suppressing IFN-gamma production: defining a novel role for IFN-gamma in the regulation of allergic airway inflammation. Journal Of Immunology (Baltimore, Md. : 1950) 2001, 166: 2760-7. PMID: 11160342, DOI: 10.4049/jimmunol.166.4.2760.
- Wang Z, Zheng T, Zhu Z, Homer RJ, Riese RJ, Chapman HA, Shapiro SD, Elias JA. Interferon gamma induction of pulmonary emphysema in the adult murine lung. The Journal Of Experimental Medicine 2000, 192: 1587-600. PMID: 11104801, PMCID: PMC2193095, DOI: 10.1084/jem.192.11.1587.
- Zheng T, Zhu Z, Wang Z, Homer RJ, Ma B, Riese RJ, Chapman HA, Shapiro SD, Elias JA. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. The Journal Of Clinical Investigation 2000, 106: 1081-93. PMID: 11067861, PMCID: PMC301418, DOI: 10.1172/JCI10458.
- Wang J, Homer RJ, Chen Q, Elias JA. Endogenous and exogenous IL-6 inhibit aeroallergen-induced Th2 inflammation. Journal Of Immunology (Baltimore, Md. : 1950) 2000, 165: 4051-61. PMID: 11034416, DOI: 10.4049/jimmunol.165.7.4051.
- Corne J, Chupp G, Lee CG, Homer RJ, Zhu Z, Chen Q, Ma B, Du Y, Roux F, McArdle J, Waxman AB, Elias JA. IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury. The Journal Of Clinical Investigation 2000, 106: 783-91. PMID: 10995789, PMCID: PMC381393, DOI: 10.1172/JCI9674.
- Wang J, Homer RJ, Hong L, Cohn L, Lee CG, Jung S, Elias JA. IL-11 selectively inhibits aeroallergen-induced pulmonary eosinophilia and Th2 cytokine production. Journal Of Immunology (Baltimore, Md. : 1950) 2000, 165: 2222-31. PMID: 10925310, DOI: 10.4049/jimmunol.165.4.2222.
- Jain D, Sarode VR, Abdul-Karim FW, Homer R, Robert ME. Evidence for the neoplastic transformation of Von-Meyenburg complexes. The American Journal Of Surgical Pathology 2000, 24: 1131-9. PMID: 10935654, DOI: 10.1097/00000478-200008000-00011.
- Powsner SM, Costa J, Homer RJ. Clinicians are from Mars and pathologists are from Venus. Archives Of Pathology & Laboratory Medicine 2000, 124: 1040-6. PMID: 10888781, DOI: 10.1043/0003-9985(2000)124<1040:CAFMAP>2.0.CO;2.
- Homer RJ, Elias JA. Consequences of long-term inflammation. Airway remodeling. Clinics In Chest Medicine 2000, 21: 331-43, ix. PMID: 10907592, DOI: 10.1016/s0272-5231(05)70270-7.
- Ward NS, Waxman AB, Homer RJ, Mantell LL, Einarsson O, Du Y, Elias JA. Interleukin-6-induced protection in hyperoxic acute lung injury. American Journal Of Respiratory Cell And Molecular Biology 2000, 22: 535-42. PMID: 10783124, DOI: 10.1165/ajrcmb.22.5.3808.
- Kuhn C, Homer RJ, Zhu Z, Ward N, Elias JA. Morphometry explains variation in airway responsiveness in transgenic mice overexpressing interleukin-6 and interleukin-11 in the lung. Chest 2000, 117: 260S-2S. PMID: 10843940.
- Kuhn C, Homer RJ, Zhu Z, Ward N, Flavell RA, Geba GP, Elias JA. Airway hyperresponsiveness and airway obstruction in transgenic mice. Morphologic correlates in mice overexpressing interleukin (IL)-11 and IL-6 in the lung. American Journal Of Respiratory Cell And Molecular Biology 2000, 22: 289-95. PMID: 10696065, DOI: 10.1165/ajrcmb.22.3.3690.
- Cohn L, Homer RJ, Niu N, Bottomly K. T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production. The Journal Of Experimental Medicine 1999, 190: 1309-18. PMID: 10544202, PMCID: PMC2195688, DOI: 10.1084/jem.190.9.1309.
- Zhang DH, Yang L, Cohn L, Parkyn L, Homer R, Ray P, Ray A. Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3. Immunity 1999, 11: 473-82. PMID: 10549629.
- Elias JA, Zhu Z, Chupp G, Homer RJ. Airway remodeling in asthma. The Journal Of Clinical Investigation 1999, 104: 1001-6. PMID: 10525034, PMCID: PMC408860, DOI: 10.1172/JCI8124.
- Waxman AB, Einarsson O, Seres T, Knickelbein RG, Homer R, Warshaw JB, Johnston R, Elias JA. Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation. Chest 1999, 116: 8S-9S. PMID: 10424559, DOI: 10.1378/chest.116.suppl_1.8s.
- Bromberg ME, Sundaram R, Homer RJ, Garen A, Konigsberg WH. Role of tissue factor in metastasis: functions of the cytoplasmic and extracellular domains of the molecule. Thrombosis And Haemostasis 1999, 82: 88-92. PMID: 10456459.
- Cohn L, Homer RJ, MacLeod H, Mohrs M, Brombacher F, Bottomly K. Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils. Journal Of Immunology (Baltimore, Md. : 1950) 1999, 162: 6178-83. PMID: 10229862.
- Zhu Z, Homer RJ, Wang Z, Chen Q, Geba GP, Wang J, Zhang Y, Elias JA. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. The Journal Of Clinical Investigation 1999, 103: 779-88. PMID: 10079098, PMCID: PMC408149, DOI: 10.1172/JCI5909.
- Homer RJ. Antineutrophil cytoplasmic antibodies as markers for systemic autoimmune disease. Clinics In Chest Medicine 1998, 19: 627-39, viii. PMID: 9917957, DOI: 10.1016/s0272-5231(05)70107-6.
- Yang L, Cohn L, Zhang DH, Homer R, Ray A, Ray P. Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation. The Journal Of Experimental Medicine 1998, 188: 1739-50. PMID: 9802985, PMCID: PMC2212522, DOI: 10.1084/jem.188.9.1739.
- Waxman AB, Einarsson O, Seres T, Knickelbein RG, Warshaw JB, Johnston R, Homer RJ, Elias JA. Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation. The Journal Of Clinical Investigation 1998, 101: 1970-82. PMID: 9576762, PMCID: PMC508784, DOI: 10.1172/JCI1337.
- Panzini L, Homer RJ. Duodenal hemangioendothelioma: a case report. The American Journal Of Gastroenterology 1998, 93: 832-3. PMID: 9625139, DOI: 10.1111/j.1572-0241.1998.236_a.x.
- Cohn L, Homer RJ, Marinov A, Rankin J, Bottomly K. Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. The Journal Of Experimental Medicine 1997, 186: 1737-47. PMID: 9362533, PMCID: PMC2199146, DOI: 10.1084/jem.186.10.1737.
- Ray P, Tang W, Wang P, Homer R, Kuhn C, Flavell RA, Elias JA. Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes. The Journal Of Clinical Investigation 1997, 100: 2501-11. PMID: 9366564, PMCID: PMC508450, DOI: 10.1172/JCI119792.
- Trawick D, Kotch A, Matthay R, Homer RJ. Eosinophilic pneumonia as a presentation of occult chronic granulomatous disease. The European Respiratory Journal 1997, 10: 2166-70. PMID: 9311521, DOI: 10.1183/09031936.97.10092166.
- Redlich CA, Karol MH, Graham C, Homer RJ, Holm CT, Wirth JA, Cullen MR. Airway isocyanate-adducts in asthma induced by exposure to hexamethylene diisocyanate. Scandinavian Journal Of Work, Environment & Health 1997, 23: 227-31. PMID: 9243734, DOI: 10.5271/sjweh.203.
- Tang W, Geba GP, Zheng T, Ray P, Homer RJ, Kuhn C, Flavell RA, Elias JA. Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction. The Journal Of Clinical Investigation 1996, 98: 2845-53. PMID: 8981933, PMCID: PMC507752, DOI: 10.1172/JCI119113.
- Redlich CA, Homer RJ, Smith BR, Wirth JA, Cullen MR. Immunologic responses to isocyanates in sensitized asthmatic subjects. Chest 1996, 109: 6S-8S. PMID: 8598159.
- Homer RJ, Khoo L, Smith GJ. Diffuse panbronchiolitis in a Hispanic man with travel history to Japan. Chest 1995, 107: 1176-8. PMID: 7705137, DOI: 10.1378/chest.107.4.1176.
- Homer RJ. Hubert Humphrey's bladder cancer. The New England Journal Of Medicine 1994, 331: 880; author reply 880-1. PMID: 8078544.
- Azrin MA, Ling FS, Chen Q, Pawashe A, Migliaccio F, Homer R, Todd M, Ezekowitz MD. Preparation, characterization, and evaluation of a monoclonal antibody against the rabbit platelet glycoprotein IIb/IIIa in an experimental angioplasty model. Circulation Research 1994, 75: 268-77. PMID: 8033340.
- Homer RJ, Mamalaki C, Kioussis D, Flavell RA. T cell unresponsiveness correlates with quantitative TCR levels in a transgenic model. International Immunology 1993, 5: 1495-500. PMID: 7906139, DOI: 10.1093/intimm/5.12.1495.
- Ruddle NH, Homer R. The role of lymphotoxin in inflammation. Progress In Allergy 1988, 40: 162-82. PMID: 3281169.
- Homer RJ, Murphy DB. Qc-1, a novel Q-region-controlled CTL determinant expressed on B lymphocytes. Journal Of Immunology (Baltimore, Md. : 1950) 1987, 138: 4322-8. PMID: 2438340.
- Murphy DB, Horowitz MC, Homer RJ, Flood PM. Genetic, serological and functional analysis of I-J molecules. Immunological Reviews 1985, 83: 79-103. PMID: 3160653, DOI: 10.1111/j.1600-065x.1985.tb00471.x.
Biography
Robert Homer, MD, PhD, a pathologist, specializes in detecting diseases including cancers in and around the lungs. He is particularly interested in lung diseases leading to fibrosis, including those from exposures to foreign materials. He became interested in pathology as a graduate student—he wanted to know more about the structure and mechanisms of disease.
Dr. Homer is a professor of pathology at Yale School of Medicine.
Titles
- Professor of Pathology
- Director, Thoracic Pathology
- Director of Medical Studies
- Director, Medical Student Course Module
Education & Training
- ResidentYale-New Haven Hospital (1992)
- PhDYale University (1987)
- MDYale University (1987)
Additional Information
Honors & Recognitions
- Keynote address: Pulmonary Pathology Society (2009)
Board Certifications
- AB of Pathology, Anatomic Pathology (1991)
Professional Service
- Yale School of Medicine (2009 - 2012): Term Appointments and Promotion committee
Publications
- Baine MK, Febres-Aldana CA, Chang JC, Jungbluth AA, Sethi S, Antonescu CR, Travis WD, Hsieh MS, Roh MS, Homer RJ, Ladanyi M, Egger JV, Lai WV, Rudin CM, Rekhtman N. POU2F3 in SCLC: Clinicopathologic and Genomic Analysis With a Focus on Its Diagnostic Utility in Neuroendocrine-Low SCLC. Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer 2022, 17: 1109-1121. PMID: 35760287, PMCID: PMC9427708, DOI: 10.1016/j.jtho.2022.06.004.
- Fernández-Castañeda A, Lu P, Geraghty AC, Song E, Lee MH, Wood J, O'Dea MR, Dutton S, Shamardani K, Nwangwu K, Mancusi R, Yalçın B, Taylor KR, Acosta-Alvarez L, Malacon K, Keough MB, Ni L, Woo PJ, Contreras-Esquivel D, Toland AMS, Gehlhausen JR, Klein J, Takahashi T, Silva J, Israelow B, Lucas C, Mao T, Peña-Hernández MA, Tabachnikova A, Homer RJ, Tabacof L, Tosto-Mancuso J, Breyman E, Kontorovich A, McCarthy D, Quezado M, Vogel H, Hefti MM, Perl DP, Liddelow S, Folkerth R, Putrino D, Nath A, Iwasaki A, Monje M. Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation. Cell 2022, 185: 2452-2468.e16. PMID: 35768006, PMCID: PMC9189143, DOI: 10.1016/j.cell.2022.06.008.
- Shafi S, Aung TN, Robbins C, Zugazagoitia J, Vathiotis I, Gavrielatou N, Yaghoobi V, Fernandez A, Niu S, Liu LN, Cusumano ZT, Leelatian N, Cole K, Wang H, Homer R, Herbst RS, Langermann S, Rimm DL. Development of an immunohistochemical assay for Siglec-15. Laboratory Investigation; A Journal Of Technical Methods And Pathology 2022, 102: 771-778. PMID: 35459795, PMCID: PMC9253057, DOI: 10.1038/s41374-022-00785-9.
- Damsky W, Wang A, Kim DJ, Young BD, Singh K, Murphy MJ, Daccache J, Clark A, Ayasun R, Ryu C, McGeary MK, Odell ID, Fazzone-Chettiar R, Pucar D, Homer R, Gulati M, Miller EJ, Bosenberg M, Flavell RA, King B. Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis. Nature Communications 2022, 13: 3140. PMID: 35668129, PMCID: PMC9170782, DOI: 10.1038/s41467-022-30615-x.
- Suberi A, Grun MK, Mao T, Israelow B, Reschke M, Grundler J, Akhtar L, Lee T, Shin K, Piotrowski-Daspit AS, Homer RJ, Iwasaki A, Suh HW, Saltzman WM. Inhalable polymer nanoparticles for versatile mRNA delivery and mucosal vaccination. BioRxiv : The Preprint Server For Biology 2022 PMID: 35350207, PMCID: PMC8963702, DOI: 10.1101/2022.03.22.485401.
- Kulkarni HS, Lee JS, Bastarache JA, Kuebler WM, Downey GP, Albaiceta GM, Altemeier WA, Artigas A, Bates JHT, Calfee CS, Dela Cruz CS, Dickson RP, Englert JA, Everitt JI, Fessler MB, Gelman AE, Gowdy KM, Groshong SD, Herold S, Homer RJ, Horowitz JC, Hsia CCW, Kurahashi K, Laubach VE, Looney MR, Lucas R, Mangalmurti NS, Manicone AM, Martin TR, Matalon S, Matthay MA, McAuley DF, McGrath-Morrow SA, Mizgerd JP, Montgomery SA, Moore BB, Noël A, Perlman CE, Reilly JP, Schmidt EP, Skerrett SJ, Suber TL, Summers C, Suratt BT, Takata M, Tuder R, Uhlig S, Witzenrath M, Zemans RL, Matute-Bello G. Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report. American Journal Of Respiratory Cell And Molecular Biology 2022, 66: e1-e14. PMID: 35103557, PMCID: PMC8845128, DOI: 10.1165/rcmb.2021-0531ST.
- Mao T, Israelow B, Suberi A, Zhou L, Reschke M, Peña-Hernández MA, Dong H, Homer RJ, Saltzman WM, Iwasaki A. Unadjuvanted intranasal spike vaccine booster elicits robust protective mucosal immunity against sarbecoviruses. BioRxiv : The Preprint Server For Biology 2022 PMID: 35118464, PMCID: PMC8811895, DOI: 10.1101/2022.01.24.477597.
- Robles-Oteiza C, Ayeni D, Levy S, Homer RJ, Kaech SM, Politi K. Elevated murine HB-EGF confers sensitivity to diphtheria toxin in EGFR-mutant lung adenocarcinoma. Disease Models & Mechanisms 2021, 14 PMID: 34494649, PMCID: PMC8617309, DOI: 10.1242/dmm.049072.
- Schupp JC, Adams TS, Cosme C, Raredon MSB, Yuan Y, Omote N, Poli S, Chioccioli M, Rose KA, Manning EP, Sauler M, DeIuliis G, Ahangari F, Neumark N, Habermann AC, Gutierrez AJ, Bui LT, Lafyatis R, Pierce RW, Meyer KB, Nawijn MC, Teichmann SA, Banovich NE, Kropski JA, Niklason LE, Pe'er D, Yan X, Homer RJ, Rosas IO, Kaminski N. Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung. Circulation 2021, 144: 286-302. PMID: 34030460, PMCID: PMC8300155, DOI: 10.1161/CIRCULATIONAHA.120.052318.
- Foggetti G, Li C, Cai H, Hellyer JA, Lin WY, Ayeni D, Hastings K, Choi J, Wurtz A, Andrejka L, Maghini DG, Rashleigh N, Levy S, Homer R, Gettinger SN, Diehn M, Wakelee HA, Petrov DA, Winslow MM, Politi K. Genetic Determinants of EGFR-Driven Lung Cancer Growth and Therapeutic Response In Vivo. Cancer Discovery 2021, 11: 1736-1753. PMID: 33707235, PMCID: PMC8530463, DOI: 10.1158/2159-8290.CD-20-1385.
- Uhlig J, Mehta S, Case MD, Dhanasopon A, Blasberg J, Homer RJ, Solomon SB, Kim HS. Effectiveness of Thermal Ablation and Stereotactic Radiotherapy Based on Stage I Lung Cancer Histology. Journal Of Vascular And Interventional Radiology : JVIR 2021, 32: 1022-1028.e4. PMID: 33811997, DOI: 10.1016/j.jvir.2021.02.025.
- Camp R, Smith ML, Larsen BT, Roden AC, Farver C, Moreira AL, Attanoos R, Pillappa R, Sansano I, Fabro AT, Homer RJ. Reliability of histopathologic diagnosis of fibrotic interstitial lung disease: an international collaborative standardization project. BMC Pulmonary Medicine 2021, 21: 184. PMID: 34074264, PMCID: PMC8170950, DOI: 10.1186/s12890-021-01522-6.
- Torres R, Olson E, Homer R, Martin DT, Levene MJ, Perincheri S, Sprenkle PC, Humphrey PA. Initial Evaluation of Rapid, Direct-to-Digital Prostate Biopsy Pathology. Archives Of Pathology & Laboratory Medicine 2021, 145: 583-591. PMID: 32991670, DOI: 10.5858/arpa.2020-0037-OA.
- Gao R, Peng X, Perry C, Sun H, Ntokou A, Ryu C, Gomez JL, Reeves BC, Walia A, Kaminski N, Neumark N, Ishikawa G, Black KE, Hariri LP, Moore MW, Gulati M, Homer RJ, Greif DM, Eltzschig HK, Herzog EL. Macrophage-derived netrin-1 drives adrenergic nerve-associated lung fibrosis. The Journal Of Clinical Investigation 2021, 131 PMID: 33393489, PMCID: PMC7773383, DOI: 10.1172/JCI136542.
- Pednekar P, Amoah K, Homer R, Ryu C, Lutchmansingh DD. Case Report: Bullous Lung Disease Following COVID-19. Frontiers In Medicine 2021, 8: 770778. PMID: 34869488, PMCID: PMC8635639, DOI: 10.3389/fmed.2021.770778.
- Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer RJ, Ring A, Wilen CB, Iwasaki A. Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. The Journal Of Experimental Medicine 2020, 217 PMID: 32750141, PMCID: PMC7401025, DOI: 10.1084/jem.20201241.
- Jiang R, Hoehn KB, Lee CS, Pham MC, Homer RJ, Detterbeck FC, Aban I, Jacobson L, Vincent A, Nowak RJ, Kaminski HJ, Kleinstein SH, O'Connor KC. Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 30649-30660. PMID: 33199596, PMCID: PMC7720237, DOI: 10.1073/pnas.2007206117.
- Adams TS, Schupp JC, Poli S, Ayaub EA, Neumark N, Ahangari F, Chu SG, Raby BA, DeIuliis G, Januszyk M, Duan Q, Arnett HA, Siddiqui A, Washko GR, Homer R, Yan X, Rosas IO, Kaminski N. Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis. Science Advances 2020, 6: eaba1983. PMID: 32832599, PMCID: PMC7439502, DOI: 10.1126/sciadv.aba1983.
- Adams TS, Schupp JC, Poli S, Ayaub EA, Neumark N, Ahangari F, Chu SG, Raby BA, DeIuliis G, Januszyk M, Duan Q, Arnett HA, Siddiqui A, Washko GR, Homer R, Yan X, Rosas IO, Kaminski N. Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis. Science Advances 2020, 6 PMID: 32937511, DOI: 10.1126/sciadv.aba1983.
- Goldman-Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer R, Ring A, Wilen C, Iwasaki A. Mouse Model of SARS-CoV-2 Reveals Inflammatory Role of Type I Interferon Signaling. SSRN 2020, 3628297. PMID: 32714125, PMCID: PMC7366812, DOI: 10.2139/ssrn.3628297.
- Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer RJ, Ring A, Wilen CB, Iwasaki A. Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. BioRxiv : The Preprint Server For Biology 2020 PMID: 32577647, PMCID: PMC7302201, DOI: 10.1101/2020.05.27.118893.
- Starrett JH, Guernet AA, Cuomo ME, Poels KE, van Alderwerelt van Rosenburgh IK, Nagelberg A, Farnsworth D, Price KS, Khan H, Ashtekar KD, Gaefele M, Ayeni D, Stewart TF, Kuhlmann A, Kaech S, Unni AM, Homer R, Lockwood WW, Michor F, Goldberg SB, Lemmon MA, Smith PD, Cross DA, Politi K. Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations. Cancer Research 2020, 80: 2017-2030. PMID: 32193290, PMCID: PMC7392201, DOI: 10.1158/0008-5472.CAN-19-3819.
- Baine MK, Sinard JH, Cai G, Homer RJ. A Semiquantitative Scoring System May Allow Biopsy Diagnosis of Pulmonary Large Cell Neuroendocrine Carcinoma. American Journal Of Clinical Pathology 2020, 153: 165-174. PMID: 31593583, PMCID: PMC7571487, DOI: 10.1093/ajcp/aqz149.
- McDonough JE, Ahangari F, Li Q, Jain S, Verleden SE, Herazo-Maya J, Vukmirovic M, DeIuliis G, Tzouvelekis A, Tanabe N, Chu F, Yan X, Verschakelen J, Homer RJ, Manatakis DV, Zhang J, Ding J, Maes K, De Sadeleer L, Vos R, Neyrinck A, Benos PV, Bar-Joseph Z, Tantin D, Hogg JC, Vanaudenaerde BM, Wuyts WA, Kaminski N. Transcriptional regulatory model of fibrosis progression in the human lung. JCI Insight 2019, 4 PMID: 31600171, PMCID: PMC6948862, DOI: 10.1172/jci.insight.131597.
- Mazer BL, Homer RJ, Rimm DL. False-positive pathology: improving reproducibility with the next generation of pathologists. Laboratory Investigation; A Journal Of Technical Methods And Pathology 2019, 99: 1260-1265. PMID: 31019290, DOI: 10.1038/s41374-019-0257-2.
- Ayeni D, Miller B, Kuhlmann A, Ho PC, Robles-Oteiza C, Gaefele M, Levy S, de Miguel FJ, Perry C, Guan T, Krystal G, Lockwood W, Zelterman D, Homer R, Liu Z, Kaech S, Politi K. Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration of inflammatory immune cells in EGFR mutant lung tumors. Journal For Immunotherapy Of Cancer 2019, 7: 172. PMID: 31291990, PMCID: PMC6617639, DOI: 10.1186/s40425-019-0643-8.
- Rimm DL, Han G, Taube JM, Yi ES, Bridge JA, Flieder DB, Homer R, Roden AC, Hirsch FR, Wistuba II, Pusztai L. Reanalysis of the NCCN PD-L1 companion diagnostic assay study for lung cancer in the context of PD-L1 expression findings in triple-negative breast cancer. Breast Cancer Research : BCR 2019, 21: 72. PMID: 31196152, PMCID: PMC6567382, DOI: 10.1186/s13058-019-1156-6.
- Kudo E, Song E, Yockey LJ, Rakib T, Wong PW, Homer RJ, Iwasaki A. Low ambient humidity impairs barrier function and innate resistance against influenza infection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 10905-10910. PMID: 31085641, PMCID: PMC6561219, DOI: 10.1073/pnas.1902840116.
- Kelleher DW, Yaggi M, Homer R, Herzog EL, Ryu C. A rare presentation of pulmonary sarcoidosis as a solitary lung mass: a case report. Journal Of Medical Case Reports 2018, 12: 94. PMID: 29650028, PMCID: PMC5897926, DOI: 10.1186/s13256-018-1632-0.
- Yu G, Tzouvelekis A, Wang R, Herazo-Maya JD, Ibarra GH, Srivastava A, de Castro JPW, DeIuliis G, Ahangari F, Woolard T, Aurelien N, Arrojo E Drigo R, Gan Y, Graham M, Liu X, Homer RJ, Scanlan TS, Mannam P, Lee PJ, Herzog EL, Bianco AC, Kaminski N. Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function. Nature Medicine 2018, 24: 39-49. PMID: 29200204, PMCID: PMC5760280, DOI: 10.1038/nm.4447.
- Rimm DL, Han G, Taube JM, Yi ES, Bridge JA, Flieder DB, Homer R, West WW, Wu H, Roden AC, Fujimoto J, Yu H, Anders R, Kowalewski A, Rivard C, Rehman J, Batenchuk C, Burns V, Hirsch FR, Wistuba II. A Prospective, Multi-institutional, Pathologist-Based Assessment of 4 Immunohistochemistry Assays for PD-L1 Expression in Non-Small Cell Lung Cancer. JAMA Oncology 2017, 3: 1051-1058. PMID: 28278348, PMCID: PMC5650234, DOI: 10.1001/jamaoncol.2017.0013.
- Homer R, Lederer DJ. Diagnosing idiopathic pulmonary fibrosis without a lung biopsy: honeycombing not required. Thorax 2017, 72: 391-392. PMID: 28280234, DOI: 10.1136/thoraxjnl-2016-209831.
- Tzouvelekis A, Yu G, Lino Cardenas CL, Herazo-Maya JD, Wang R, Woolard T, Zhang Y, Sakamoto K, Lee H, Yi JS, DeIuliis G, Xylourgidis N, Ahangari F, Lee PJ, Aidinis V, Herzog EL, Homer R, Bennett AM, Kaminski N. SH2 Domain-Containing Phosphatase-2 Is a Novel Antifibrotic Regulator in Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2017, 195: 500-514. PMID: 27736153, PMCID: PMC5378419, DOI: 10.1164/rccm.201602-0329OC.
- Ryu C, Herzog EL, Pan H, Homer R, Gulati M. Upper Airway Obstruction Requiring Emergent Tracheostomy Secondary to Laryngeal Sarcoidosis: A Case Report. The American Journal Of Case Reports 2017, 18: 157-159. PMID: 28190872, PMCID: PMC5319306, DOI: 10.12659/ajcr.902231.
- Uraki R, Hwang J, Jurado KA, Householder S, Yockey LJ, Hastings AK, Homer RJ, Iwasaki A, Fikrig E. Zika virus causes testicular atrophy. Science Advances 2017, 3: e1602899. PMID: 28261663, PMCID: PMC5321463, DOI: 10.1126/sciadv.1602899.
- Vukmirovic M, Herazo-Maya JD, Blackmon J, Skodric-Trifunovic V, Jovanovic D, Pavlovic S, Stojsic J, Zeljkovic V, Yan X, Homer R, Stefanovic B, Kaminski N. Identification and validation of differentially expressed transcripts by RNA-sequencing of formalin-fixed, paraffin-embedded (FFPE) lung tissue from patients with Idiopathic Pulmonary Fibrosis. BMC Pulmonary Medicine 2017, 17: 15. PMID: 28081703, PMCID: PMC5228096, DOI: 10.1186/s12890-016-0356-4.
- Golestani R, Razavian M, Ye Y, Zhang J, Jung JJ, Toczek J, Gona K, Kim HY, Elias JA, Lee CG, Homer RJ, Sadeghi MM. Matrix Metalloproteinase-Targeted Imaging of Lung Inflammation and Remodeling. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2017, 58: 138-143. PMID: 27469361, PMCID: PMC5209638, DOI: 10.2967/jnumed.116.176198.
- Peng X, Moore M, Mathur A, Zhou Y, Sun H, Gan Y, Herazo-Maya JD, Kaminski N, Hu X, Pan H, Ryu C, Osafo-Addo A, Homer RJ, Feghali-Bostwick C, Fares W, Gulati M, Hu B, Lee CG, Elias JA, Herzog EL. Plexin C1 deficiency permits synaptotagmin 7-mediated macrophage migration and enhances mammalian lung fibrosis. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2016, 30: 4056-4070. PMID: 27609773, PMCID: PMC5102121, DOI: 10.1096/fj.201600373R.
- Sureshbabu A, Syed M, Das P, Janér C, Pryhuber G, Rahman A, Andersson S, Homer RJ, Bhandari V. Inhibition of Regulatory-Associated Protein of Mechanistic Target of Rapamycin Prevents Hyperoxia-Induced Lung Injury by Enhancing Autophagy and Reducing Apoptosis in Neonatal Mice. American Journal Of Respiratory Cell And Molecular Biology 2016, 55: 722-735. PMID: 27374190, PMCID: PMC5105179, DOI: 10.1165/rcmb.2015-0349OC.
- Rimm D, Han G, Taube JM, Yi ES, Bridge JA, Flieder DB, Homer R, West WW, Wu H, Roden AC, Fujimoto J, Yu H, Anders R, Kowalewski A, Rivard C, Rehman J, Hirsch F, Wistuba II. ORAL01.01: A Prospective, Multi-Institutional Assessment of Four Assays for PD-L1 Expression in NSCLC by Immunohistochemistry: Topic: Pathology. Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer 2016, 11: S249. PMID: 27969440, DOI: 10.1016/j.jtho.2016.09.006.
- Forloni M, Gupta R, Nagarajan A, Sun LS, Dong Y, Pirazzoli V, Toki M, Wurtz A, Melnick MA, Kobayashi S, Homer RJ, Rimm DL, Gettinger SJ, Politi K, Dogra SK, Wajapeyee N. Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells. Cell Reports 2016, 16: 457-471. PMID: 27346347, PMCID: PMC4945411, DOI: 10.1016/j.celrep.2016.05.087.
- Ryu C, Homer RJ, Herzog EL. The Airway in Idiopathic Pulmonary Fibrosis: Protecting the Lung or Promoting Disease? American Journal Of Respiratory And Critical Care Medicine 2016, 193: 1081-2. PMID: 27174477, PMCID: PMC4872674, DOI: 10.1164/rccm.201601-0055ED.
- Bramley K, Pisani MA, Murphy TE, Araujo KL, Homer RJ, Puchalski JT. Endobronchial Ultrasound-Guided Cautery-Assisted Transbronchial Forceps Biopsies: Safety and Sensitivity Relative to Transbronchial Needle Aspiration. The Annals Of Thoracic Surgery 2016, 101: 1870-6. PMID: 26912301, PMCID: PMC4861078, DOI: 10.1016/j.athoracsur.2015.11.051.
- Pillai PS, Molony RD, Martinod K, Dong H, Pang IK, Tal MC, Solis AG, Bielecki P, Mohanty S, Trentalange M, Homer RJ, Flavell RA, Wagner DD, Montgomery RR, Shaw AC, Staeheli P, Iwasaki A. Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease. Science (New York, N.Y.) 2016, 352: 463-6. PMID: 27102485, PMCID: PMC5465864, DOI: 10.1126/science.aaf3926.
- Bruscia E, Zhang PX, Barone C, Scholte B, Homer RJ, Krause D, Egan ME. Increased susceptibility of Cftr-/- mice to LPS-induced lung remodeling. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2016, 310: L711-9. PMID: 26851259, PMCID: PMC4836110, DOI: 10.1152/ajplung.00284.2015.
- Ramaswamy A, Homer R, Killam J, Pisani MA, Murphy TE, Araujo K, Puchalski J. Comparison of Transbronchial and Cryobiopsies in Evaluation of Diffuse Parenchymal Lung Disease. Journal Of Bronchology & Interventional Pulmonology 2016, 23: 14-21. PMID: 26705007, PMCID: PMC4864578, DOI: 10.1097/LBR.0000000000000246.
- Syed MA, Choo-Wing R, Homer RJ, Bhandari V. Role of Nitric Oxide Isoforms in Vascular and Alveolar Development and Lung Injury in Vascular Endothelial Growth Factor Overexpressing Neonatal Mice Lungs. PloS One 2016, 11: e0147588. PMID: 26799210, PMCID: PMC4723240, DOI: 10.1371/journal.pone.0147588.
- Kang MJ, Yoon CM, Kim BH, Lee CM, Zhou Y, Sauler M, Homer R, Dhamija A, Boffa D, West AP, Shadel GS, Ting JP, Tedrow JR, Kaminski N, Kim WJ, Lee CG, Oh YM, Elias JA. Suppression of NLRX1 in chronic obstructive pulmonary disease. The Journal Of Clinical Investigation 2015, 125: 2458-62. PMID: 25938787, PMCID: PMC4497738, DOI: 10.1172/JCI71747.
- Homer RJ. Pathologists' staging of multiple foci of lung cancer: poor concordance in absence of dramatic histologic or molecular differences. American Journal Of Clinical Pathology 2015, 143: 701-6. PMID: 25873504, DOI: 10.1309/AJCPNBWF55VGKOIW.
- Sureshbabu A, Syed MA, Boddupalli CS, Dhodapkar MV, Homer RJ, Minoo P, Bhandari V. Conditional overexpression of TGFβ1 promotes pulmonary inflammation, apoptosis and mortality via TGFβR2 in the developing mouse lung. Respiratory Research 2015, 16: 4. PMID: 25591994, PMCID: PMC4307226, DOI: 10.1186/s12931-014-0162-6.
- Lee N, You S, Shin MS, Lee WW, Kang KS, Kim SH, Kim WU, Homer RJ, Kang MJ, Montgomery RR, Dela Cruz CS, Shaw AC, Lee PJ, Chupp GL, Hwang D, Kang I. IL-6 receptor α defines effector memory CD8+ T cells producing Th2 cytokines and expanding in asthma. American Journal Of Respiratory And Critical Care Medicine 2014, 190: 1383-94. PMID: 25390970, PMCID: PMC4299645, DOI: 10.1164/rccm.201403-0601OC.
- Zhang X, Shan P, Homer R, Zhang Y, Petrache I, Mannam P, Lee PJ. Cathepsin E promotes pulmonary emphysema via mitochondrial fission. The American Journal Of Pathology 2014, 184: 2730-41. PMID: 25239563, PMCID: PMC4188869, DOI: 10.1016/j.ajpath.2014.06.017.
- Lafferty EI, Flaczyk A, Angers I, Homer R, d'Hennezel E, Malo D, Piccirillo CA, Vidal SM, Qureshi ST. An ENU-induced splicing mutation reveals a role for Unc93b1 in early immune cell activation following influenza A H1N1 infection. Genes And Immunity 2014, 15: 320-32. PMID: 24848930, PMCID: PMC4978536, DOI: 10.1038/gene.2014.22.
- Zhou Y, Peng H, Sun H, Peng X, Tang C, Gan Y, Chen X, Mathur A, Hu B, Slade MD, Montgomery RR, Shaw AC, Homer RJ, White ES, Lee CM, Moore MW, Gulati M, Lee CG, Elias JA, Herzog EL. Chitinase 3-like 1 suppresses injury and promotes fibroproliferative responses in Mammalian lung fibrosis. Science Translational Medicine 2014, 6: 240ra76. PMID: 24920662, PMCID: PMC4340473, DOI: 10.1126/scitranslmed.3007096.
- Peng X, Moore MW, Peng H, Sun H, Gan Y, Homer RJ, Herzog EL. CD4+CD25+FoxP3+ Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-β1 exposed murine lung. Frontiers In Pharmacology 2014, 5: 80. PMID: 24904415, PMCID: PMC4032896, DOI: 10.3389/fphar.2014.00080.
- Cai G, Wong R, Chhieng D, Levy GH, Gettinger SN, Herbst RS, Puchalski JT, Homer RJ, Hui P. Identification of EGFR mutation, KRAS mutation, and ALK gene rearrangement in cytological specimens of primary and metastatic lung adenocarcinoma. Cancer Cytopathology 2013, 121: 500-7. PMID: 23495083, DOI: 10.1002/cncy.21288.
- Jamieson AM, Pasman L, Yu S, Gamradt P, Homer RJ, Decker T, Medzhitov R. Role of tissue protection in lethal respiratory viral-bacterial coinfection. Science (New York, N.Y.) 2013, 340: 1230-4. PMID: 23618765, PMCID: PMC3933032, DOI: 10.1126/science.1233632.
- Choo-Wing R, Syed MA, Harijith A, Bowen B, Pryhuber G, Janér C, Andersson S, Homer RJ, Bhandari V. Hyperoxia and interferon-γ-induced injury in developing lungs occur via cyclooxygenase-2 and the endoplasmic reticulum stress-dependent pathway. American Journal Of Respiratory Cell And Molecular Biology 2013, 48: 749-57. PMID: 23470621, PMCID: PMC3727872, DOI: 10.1165/rcmb.2012-0381OC.
- Reilkoff RA, Peng H, Murray LA, Peng X, Russell T, Montgomery R, Feghali-Bostwick C, Shaw A, Homer RJ, Gulati M, Mathur A, Elias JA, Herzog EL. Semaphorin 7a+ regulatory T cells are associated with progressive idiopathic pulmonary fibrosis and are implicated in transforming growth factor-β1-induced pulmonary fibrosis. American Journal Of Respiratory And Critical Care Medicine 2013, 187: 180-8. PMID: 23220917, PMCID: PMC3570653, DOI: 10.1164/rccm.201206-1109OC.
- Cho WK, Lee CM, Kang MJ, Huang Y, Giordano FJ, Lee PJ, Trow TK, Homer RJ, Sessa WC, Elias JA, Lee CG. IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2013, 304: L112-24. PMID: 23125252, PMCID: PMC3543640, DOI: 10.1152/ajplung.00101.2012.
- Sun H, Choo-Wing R, Sureshbabu A, Fan J, Leng L, Yu S, Jiang D, Noble P, Homer RJ, Bucala R, Bhandari V. A critical regulatory role for macrophage migration inhibitory factor in hyperoxia-induced injury in the developing murine lung. PloS One 2013, 8: e60560. PMID: 23637753, PMCID: PMC3639272, DOI: 10.1371/journal.pone.0060560.
- Carroll SF, Lafferty EI, Flaczyk A, Fujiwara TM, Homer R, Morgan K, Loredo-Osti JC, Qureshi ST. Susceptibility to progressive Cryptococcus neoformans pulmonary infection is regulated by loci on mouse chromosomes 1 and 9. Infection And Immunity 2012, 80: 4167-76. PMID: 22988020, PMCID: PMC3497416, DOI: 10.1128/IAI.00417-12.
- Gifford AH, Matsuoka M, Ghoda LY, Homer RJ, Enelow RI. Chronic inflammation and lung fibrosis: pleotropic syndromes but limited distinct phenotypes. Mucosal Immunology 2012, 5: 480-4. PMID: 22806097, DOI: 10.1038/mi.2012.68.
- Bhandari V, Choo-Wing R, Harijith A, Sun H, Syed MA, Homer RJ, Elias JA. Increased hyperoxia-induced lung injury in nitric oxide synthase 2 null mice is mediated via angiopoietin 2. American Journal Of Respiratory Cell And Molecular Biology 2012, 46: 668-76. PMID: 22227562, PMCID: PMC3359903, DOI: 10.1165/rcmb.2011-0074OC.
- Anagnostou VK, Dimou AT, Botsis T, Killiam EJ, Gustavson MD, Homer RJ, Boffa D, Zolota V, Dougenis D, Tanoue L, Gettinger SN, Detterbeck FC, Syrigos KN, Bepler G, Rimm DL. Molecular classification of nonsmall cell lung cancer using a 4-protein quantitative assay. Cancer 2012, 118: 1607-18. PMID: 22009766, DOI: 10.1002/cncr.26450.
- Antin-Ozerkis D, Rubinowitz A, Evans J, Homer RJ, Matthay RA. Interstitial lung disease in the connective tissue diseases. Clinics In Chest Medicine 2012, 33: 123-49. PMID: 22365251, DOI: 10.1016/j.ccm.2012.01.004.
- Detterbeck FC, Homer RJ. Approach to the ground-glass nodule. Clinics In Chest Medicine 2011, 32: 799-810. PMID: 22054887, DOI: 10.1016/j.ccm.2011.08.002.
- Mitchell C, Provost K, Niu N, Homer R, Cohn L. IFN-γ acts on the airway epithelium to inhibit local and systemic pathology in allergic airway disease. Journal Of Immunology (Baltimore, Md. : 1950) 2011, 187: 3815-20. PMID: 21873527, PMCID: PMC3178669, DOI: 10.4049/jimmunol.1100436.
- Gan Y, Reilkoff R, Peng X, Russell T, Chen Q, Mathai SK, Homer R, Gulati M, Siner J, Elias J, Bucala R, Herzog E. Role of semaphorin 7a signaling in transforming growth factor β1-induced lung fibrosis and scleroderma-related interstitial lung disease. Arthritis And Rheumatism 2011, 63: 2484-94. PMID: 21484765, PMCID: PMC3651701, DOI: 10.1002/art.30386.
- Mijares LA, Wangdi T, Sokol C, Homer R, Medzhitov R, Kazmierczak BI. Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an IL-1-dependent pathway. Journal Of Immunology (Baltimore, Md. : 1950) 2011, 186: 7080-8. PMID: 21572023, PMCID: PMC3110630, DOI: 10.4049/jimmunol.1003687.
- Matsuura H, Hartl D, Kang MJ, Dela Cruz CS, Koller B, Chupp GL, Homer RJ, Zhou Y, Cho WK, Elias JA, Lee CG. Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema. American Journal Of Respiratory Cell And Molecular Biology 2011, 44: 777-86. PMID: 20656949, PMCID: PMC3135840, DOI: 10.1165/rcmb.2010-0081OC.
- Homer RJ, Elias JA, Lee CG, Herzog E. Modern concepts on the role of inflammation in pulmonary fibrosis. Archives Of Pathology & Laboratory Medicine 2011, 135: 780-8. PMID: 21631273, DOI: 10.5858/2010-0296-RA.1.
- Ma B, Dela Cruz CS, Hartl D, Kang MJ, Takyar S, Homer RJ, Lee CG, Elias JA. RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism. American Journal Of Respiratory And Critical Care Medicine 2011, 183: 1322-35. PMID: 21278304, PMCID: PMC3114061, DOI: 10.1164/rccm.201008-1276OC.
- Harijith A, Choo-Wing R, Cataltepe S, Yasumatsu R, Aghai ZH, Janér J, Andersson S, Homer RJ, Bhandari V. A role for matrix metalloproteinase 9 in IFNγ-mediated injury in developing lungs: relevance to bronchopulmonary dysplasia. American Journal Of Respiratory Cell And Molecular Biology 2011, 44: 621-30. PMID: 21216975, PMCID: PMC3095982, DOI: 10.1165/rcmb.2010-0058OC.
- Murray LA, Chen Q, Kramer MS, Hesson DP, Argentieri RL, Peng X, Gulati M, Homer RJ, Russell T, van Rooijen N, Elias JA, Hogaboam CM, Herzog EL. TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P. The International Journal Of Biochemistry & Cell Biology 2011, 43: 154-62. PMID: 21044893, DOI: 10.1016/j.biocel.2010.10.013.
- Wright PL, Yu J, Di YP, Homer RJ, Chupp G, Elias JA, Cohn L, Sessa WC. Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation. The Journal Of Experimental Medicine 2010, 207: 2595-607. PMID: 20975041, PMCID: PMC2989775, DOI: 10.1084/jem.20100786.
- Homer RJ, Herzog EL. Recent advances in pulmonary fibrosis: implications for scleroderma. Current Opinion In Rheumatology 2010, 22: 683-9. PMID: 20693906, DOI: 10.1097/BOR.0b013e32833ddcc9.
- Antin-Ozerkis D, Evans J, Rubinowitz A, Homer RJ, Matthay RA. Pulmonary manifestations of rheumatoid arthritis. Clinics In Chest Medicine 2010, 31: 451-78. PMID: 20692539, DOI: 10.1016/j.ccm.2010.04.003.
- Jiang D, Liang J, Campanella GS, Guo R, Yu S, Xie T, Liu N, Jung Y, Homer R, Meltzer EB, Li Y, Tager AM, Goetinck PF, Luster AD, Noble PW. Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4. The Journal Of Clinical Investigation 2010, 120: 2049-57. PMID: 20484822, PMCID: PMC2877927, DOI: 10.1172/JCI38644.
- Anagnostou VK, Lowery FJ, Zolota V, Tzelepi V, Gopinath A, Liceaga C, Panagopoulos N, Frangia K, Tanoue L, Boffa D, Gettinger S, Detterbeck F, Homer RJ, Dougenis D, Rimm DL, Syrigos KN. High expression of BCL-2 predicts favorable outcome in non-small cell lung cancer patients with non squamous histology. BMC Cancer 2010, 10: 186. PMID: 20459695, PMCID: PMC2875218, DOI: 10.1186/1471-2407-10-186.
- Trang P, Medina PP, Wiggins JF, Ruffino L, Kelnar K, Omotola M, Homer R, Brown D, Bader AG, Weidhaas JB, Slack FJ. Regression of murine lung tumors by the let-7 microRNA. Oncogene 2010, 29: 1580-7. PMID: 19966857, PMCID: PMC2841713, DOI: 10.1038/onc.2009.445.
- Mathai SK, Rubinowitz AN, Homer RJ, Detterbeck F, Herzog EL. Of lungs, lipids, and lollipops. Chest 2009, 136: 1420-1423. PMID: 19892683, DOI: 10.1378/chest.08-2133.
- Niu N, Laufer T, Homer RJ, Cohn L. Cutting edge: Limiting MHC class II expression to dendritic cells alters the ability to develop Th2- dependent allergic airway inflammation. Journal Of Immunology (Baltimore, Md. : 1950) 2009, 183: 1523-7. PMID: 19596982, DOI: 10.4049/jimmunol.0901349.
- Anagnostou VK, Bepler G, Syrigos KN, Tanoue L, Gettinger S, Homer RJ, Boffa D, Detterbeck F, Rimm DL. High expression of mammalian target of rapamycin is associated with better outcome for patients with early stage lung adenocarcinoma. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2009, 15: 4157-64. PMID: 19509151, DOI: 10.1158/1078-0432.CCR-09-0099.
- Caceres AI, Brackmann M, Elia MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM, Jordt SE. A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 9099-104. PMID: 19458046, PMCID: PMC2684498, DOI: 10.1073/pnas.0900591106.
- Trow TK, Morris DG, Miller CR, Homer RJ. Granulomatous bronchiolitis of Crohn's disease successfully treated with inhaled budesonide. Thorax 2009, 64: 546-7. PMID: 19478123, DOI: 10.1136/thx.2008.107185.
- Lee CG, Hartl D, Lee GR, Koller B, Matsuura H, Da Silva CA, Sohn MH, Cohn L, Homer RJ, Kozhich AA, Humbles A, Kearley J, Coyle A, Chupp G, Reed J, Flavell RA, Elias JA. Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. The Journal Of Experimental Medicine 2009, 206: 1149-66. PMID: 19414556, PMCID: PMC2715037, DOI: 10.1084/jem.20081271.
- Oh SY, Zheng T, Kim YK, Cohn L, Homer RJ, McKenzie AN, Zhu Z. A critical role of SHP-1 in regulation of type 2 inflammation in the lung. American Journal Of Respiratory Cell And Molecular Biology 2009, 40: 568-74. PMID: 18952567, PMCID: PMC2677436, DOI: 10.1165/rcmb.2008-0225OC.
- Anagnostou VK, Syrigos KN, Bepler G, Homer RJ, Rimm DL. Thyroid transcription factor 1 is an independent prognostic factor for patients with stage I lung adenocarcinoma. Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology 2009, 27: 271-8. PMID: 19064983, DOI: 10.1200/JCO.2008.17.0043.
- Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production.Lee CG, Hartl D, Matsuura H, Dunlop FM, Scotney PD, Fabri LJ, Nash AD, Chen NY, Tang CY, Chen Q, Homer RJ, Baca M, Elias JA. Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production. American Journal Of Respiratory Cell And Molecular Biology 2008, 39: 739-46. PMID: 18617680, PMCID: PMC2586049, DOI: 10.1165/rcmb.2008-0053OC.
- Hartl D, He CH, Koller B, Da Silva CA, Homer R, Lee CG, Elias JA. Acidic mammalian chitinase is secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by pulmonary epithelial cells. The Journal Of Biological Chemistry 2008, 283: 33472-82. PMID: 18824549, PMCID: PMC2586247, DOI: 10.1074/jbc.M805574200.
- Chin LJ, Ratner E, Leng S, Zhai R, Nallur S, Babar I, Muller RU, Straka E, Su L, Burki EA, Crowell RE, Patel R, Kulkarni T, Homer R, Zelterman D, Kidd KK, Zhu Y, Christiani DC, Belinsky SA, Slack FJ, Weidhaas JB. A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. Cancer Research 2008, 68: 8535-40. PMID: 18922928, PMCID: PMC2672193, DOI: 10.1158/0008-5472.CAN-08-2129.
- Bhandari V, Choo-Wing R, Lee CG, Yusuf K, Nedrelow JH, Ambalavanan N, Malkus H, Homer RJ, Elias JA. Developmental regulation of NO-mediated VEGF-induced effects in the lung. American Journal Of Respiratory Cell And Molecular Biology 2008, 39: 420-30. PMID: 18441284, PMCID: PMC2551703, DOI: 10.1165/rcmb.2007-0024OC.
- Guillot L, Carroll SF, Homer R, Qureshi ST. Enhanced innate immune responsiveness to pulmonary Cryptococcus neoformans infection is associated with resistance to progressive infection. Infection And Immunity 2008, 76: 4745-56. PMID: 18678664, PMCID: PMC2546841, DOI: 10.1128/IAI.00341-08.
- Rubinowitz AN, Moon M, Homer R. A 34-year-old man presenting with gradual onset of shortness of breath and interstitial lung disease. Chest 2008, 133: 1041-7. PMID: 18398129, DOI: 10.1378/chest.07-2235.
- Yamasaki M, Kang HR, Homer RJ, Chapoval SP, Cho SJ, Lee BJ, Elias JA, Lee CG. P21 regulates TGF-beta1-induced pulmonary responses via a TNF-alpha-signaling pathway. American Journal Of Respiratory Cell And Molecular Biology 2008, 38: 346-53. PMID: 17932374, PMCID: PMC2258454, DOI: 10.1165/rcmb.2007-0276OC.
- Zhou J, Matsuoka M, Cantor H, Homer R, Enelow RI. Cutting edge: engagement of NKG2A on CD8+ effector T cells limits immunopathology in influenza pneumonia. Journal Of Immunology (Baltimore, Md. : 1950) 2008, 180: 25-9. PMID: 18096998, DOI: 10.4049/jimmunol.180.1.25.
- Zheng T, Liu W, Oh SY, Zhu Z, Hu B, Homer RJ, Cohn L, Grusby MJ, Elias JA. IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung. Journal Of Immunology (Baltimore, Md. : 1950) 2008, 180: 522-9. PMID: 18097054, DOI: 10.4049/jimmunol.180.1.522.
- Chapoval SP, Al-Garawi A, Lora JM, Strickland I, Ma B, Lee PJ, Homer RJ, Ghosh S, Coyle AJ, Elias JA. Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 179: 7030-41. PMID: 17982094, DOI: 10.4049/jimmunol.179.10.7030.
- Kenney B, Dotto J, Homer R, Shafi N, Davydova L. Primary malignant melanoma of the transverse colon: report of a case and review of the literature. International Journal Of Surgical Pathology 2007, 15: 401-7. PMID: 17913951, DOI: 10.1177/1066896907302370.
- Homer RJ. Airway remodeling and RELM-beta. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2007, 293: L303-4. PMID: 17586697, DOI: 10.1152/ajplung.00226.2007.
- Choo-Wing R, Nedrelow JH, Homer RJ, Elias JA, Bhandari V. Developmental differences in the responses of IL-6 and IL-13 transgenic mice exposed to hyperoxia. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2007, 293: L142-50. PMID: 17400600, DOI: 10.1152/ajplung.00434.2006.
- Kenney B, Pinto M, Homer R. Benign pulmonary epithelial inclusions within the pleura: a case report. Diagnostic Pathology 2007, 2: 21. PMID: 17603877, PMCID: PMC1914110, DOI: 10.1186/1746-1596-2-21.
- Simeone-Penney MC, Severgnini M, Tu P, Homer RJ, Mariani TJ, Cohn L, Simon AR. Airway epithelial STAT3 is required for allergic inflammation in a murine model of asthma. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 178: 6191-9. PMID: 17475846, DOI: 10.4049/jimmunol.178.10.6191.
- Kang HR, Lee CG, Homer RJ, Elias JA. Semaphorin 7A plays a critical role in TGF-beta1-induced pulmonary fibrosis. The Journal Of Experimental Medicine 2007, 204: 1083-93. PMID: 17485510, PMCID: PMC2118575, DOI: 10.1084/jem.20061273.
- Bhandari V, Choo-Wing R, Homer RJ, Elias JA. Increased hyperoxia-induced mortality and acute lung injury in IL-13 null mice. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 178: 4993-5000. PMID: 17404281, DOI: 10.4049/jimmunol.178.8.4993.
- Grigoriyan A, Rishi A, Molina J, Homer R, Manthous CA. Diffuse alveolar damage and hemorrhage in acute myelogenous leukemia treated with corticosteroids. Connecticut Medicine 2007, 71: 201-4. PMID: 17487004.
- Niu N, Le Goff MK, Li F, Rahman M, Homer RJ, Cohn L. A novel pathway that regulates inflammatory disease in the respiratory tract. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 178: 3846-55. PMID: 17339484, DOI: 10.4049/jimmunol.178.6.3846.
- Kang HR, Cho SJ, Lee CG, Homer RJ, Elias JA. Transforming growth factor (TGF)-beta1 stimulates pulmonary fibrosis and inflammation via a Bax-dependent, bid-activated pathway that involves matrix metalloproteinase-12. The Journal Of Biological Chemistry 2007, 282: 7723-32. PMID: 17209037, DOI: 10.1074/jbc.M610764200.
- Kang MJ, Homer RJ, Gallo A, Lee CG, Crothers KA, Cho SJ, Rochester C, Cain H, Chupp G, Yoon HJ, Elias JA. IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 178: 1948-59. PMID: 17237446, DOI: 10.4049/jimmunol.178.3.1948.
- Temann UA, Laouar Y, Eynon EE, Homer R, Flavell RA. IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells. International Immunology 2007, 19: 1-10. PMID: 17101709, DOI: 10.1093/intimm/dxl117.
- Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA. Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nature Medicine 2006, 12: 1286-93. PMID: 17086189, PMCID: PMC2768268, DOI: 10.1038/nm1494.
- Khazeni N, Homer RJ, Rubinowitz AN, Chupp GL. Massive cavitary pulmonary rheumatoid nodules in a patient with HIV. The European Respiratory Journal 2006, 28: 872-4. PMID: 17012633, DOI: 10.1183/09031936.06.00144105.
- Homer RJ, Zhu Z, Cohn L, Lee CG, White WI, Chen S, Elias JA. Differential expression of chitinases identify subsets of murine airway epithelial cells in allergic inflammation. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2006, 291: L502-11. PMID: 16556727, DOI: 10.1152/ajplung.00364.2005.
- Elias JA, Kang MJ, Crothers K, Homer R, Lee CG. State of the art. Mechanistic heterogeneity in chronic obstructive pulmonary disease: insights from transgenic mice. Proceedings Of The American Thoracic Society 2006, 3: 494-8. PMID: 16921126, DOI: 10.1513/pats.200603-068MS.
- Lee CG, Cho S, Homer RJ, Elias JA. Genetic control of transforming growth factor-beta1-induced emphysema and fibrosis in the murine lung. Proceedings Of The American Thoracic Society 2006, 3: 476-477. PMID: 16921114, DOI: 10.1513/pats.200603-040MS.
- Kang MJ, Lee CG, Cho SJ, Homer RJ, Elias JA. IFN-gamma-dependent DNA injury and/or apoptosis are critical in cigarette smoke-induced murine emphysema. Proceedings Of The American Thoracic Society 2006, 3: 517-8. PMID: 16921135, DOI: 10.1513/pats.200603-075MS.
- Shim YM, Zhu Z, Zheng T, Lee CG, Homer RJ, Ma B, Elias JA. Role of 5-lipoxygenase in IL-13-induced pulmonary inflammation and remodeling. Journal Of Immunology (Baltimore, Md. : 1950) 2006, 177: 1918-24. PMID: 16849505, DOI: 10.4049/jimmunol.177.3.1918.
- Bhandari V, Choo-Wing R, Chapoval SP, Lee CG, Tang C, Kim YK, Ma B, Baluk P, Lin MI, McDonald DM, Homer RJ, Sessa WC, Elias JA. Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 11021-6. PMID: 16832062, PMCID: PMC1544167, DOI: 10.1073/pnas.0601057103.
- Lee CG, Kang HR, Homer RJ, Chupp G, Elias JA. Transgenic modeling of transforming growth factor-beta(1): role of apoptosis in fibrosis and alveolar remodeling. Proceedings Of The American Thoracic Society 2006, 3: 418-23. PMID: 16799085, PMCID: PMC2658706, DOI: 10.1513/pats.200602-017AW.
- Ma B, Blackburn MR, Lee CG, Homer RJ, Liu W, Flavell RA, Boyden L, Lifton RP, Sun CX, Young HW, Elias JA. Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis. The Journal Of Clinical Investigation 2006, 116: 1274-83. PMID: 16670768, PMCID: PMC1451205, DOI: 10.1172/JCI26372.
- Ma B, Liu W, Homer RJ, Lee PJ, Coyle AJ, Lora JM, Lee CG, Elias JA. Role of CCR5 in the pathogenesis of IL-13-induced inflammation and remodeling. Journal Of Immunology (Baltimore, Md. : 1950) 2006, 176: 4968-78. PMID: 16585593, DOI: 10.4049/jimmunol.176.8.4968.
- Cho SJ, Kang MJ, Homer RJ, Kang HR, Zhang X, Lee PJ, Elias JA, Lee CG. Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling. The Journal Of Biological Chemistry 2006, 281: 8161-8. PMID: 16439363, DOI: 10.1074/jbc.M506770200.
- Lee PJ, Zhang X, Shan P, Ma B, Lee CG, Homer RJ, Zhu Z, Rincon M, Mossman BT, Elias JA. ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. The Journal Of Clinical Investigation 2006, 116: 163-73. PMID: 16374521, PMCID: PMC1319220, DOI: 10.1172/JCI25711.
- Ma B, Kang MJ, Lee CG, Chapoval S, Liu W, Chen Q, Coyle AJ, Lora JM, Picarella D, Homer RJ, Elias JA. Role of CCR5 in IFN-gamma-induced and cigarette smoke-induced emphysema. The Journal Of Clinical Investigation 2005, 115: 3460-72. PMID: 16284650, PMCID: PMC1280966, DOI: 10.1172/JCI24858.
- Noble PW, Tanoue L, Homer R. Case study review. Chest 2005, 128: 540S-546S. PMID: 16304245, DOI: 10.1378/chest.128.5_suppl_1.540S.
- Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y, Prestwich GD, Mascarenhas MM, Garg HG, Quinn DA, Homer RJ, Goldstein DR, Bucala R, Lee PJ, Medzhitov R, Noble PW. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nature Medicine 2005, 11: 1173-9. PMID: 16244651, DOI: 10.1038/nm1315.
- Zhang X, Shan P, Qureshi S, Homer R, Medzhitov R, Noble PW, Lee PJ. Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury. Journal Of Immunology (Baltimore, Md. : 1950) 2005, 175: 4834-8. PMID: 16210584, DOI: 10.4049/jimmunol.175.8.4834.
- Elias JA, Homer RJ, Hamid Q, Lee CG. Chitinases and chitinase-like proteins in T(H)2 inflammation and asthma. The Journal Of Allergy And Clinical Immunology 2005, 116: 497-500. PMID: 16159614, DOI: 10.1016/j.jaci.2005.06.028.
- Noble PW, Homer RJ. Back to the future: historical perspective on the pathogenesis of idiopathic pulmonary fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2005, 33: 113-20. PMID: 16024580, DOI: 10.1165/rcmb.F301.
- Zheng T, Kang MJ, Crothers K, Zhu Z, Liu W, Lee CG, Rabach LA, Chapman HA, Homer RJ, Aldous D, De Sanctis GT, Underwood S, Graupe M, Flavell RA, Schmidt JA, Elias JA. Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema. Journal Of Immunology (Baltimore, Md. : 1950) 2005, 174: 8106-15. PMID: 15944319, DOI: 10.4049/jimmunol.174.12.8106.
- Inhibition of the Src and Jak kinases protects against lipopolysaccharide-induced acute lung injury.Severgnini M, Takahashi S, Tu P, Perides G, Homer RJ, Jhung JW, Bhavsar D, Cochran BH, Simon AR. Inhibition of the Src and Jak kinases protects against lipopolysaccharide-induced acute lung injury. American Journal Of Respiratory And Critical Care Medicine 2005, 171: 858-67. PMID: 15665321, DOI: 10.1164/rccm.200407-981OC.
- He CH, Waxman AB, Lee CG, Link H, Rabach ME, Ma B, Chen Q, Zhu Z, Zhong M, Nakayama K, Nakayama KI, Homer R, Elias JA. Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury. The Journal Of Clinical Investigation 2005, 115: 1039-48. PMID: 15841185, PMCID: PMC1070412, DOI: 10.1172/JCI23004.
- Chen Q, Rabach L, Noble P, Zheng T, Lee CG, Homer RJ, Elias JA. IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling. Journal Of Immunology (Baltimore, Md. : 1950) 2005, 174: 2305-13. PMID: 15699166, DOI: 10.4049/jimmunol.174.4.2305.
- Homer RJ, Elias JA. Airway remodeling in asthma: therapeutic implications of mechanisms. Physiology (Bethesda, Md.) 2005, 20: 28-35. PMID: 15653837, DOI: 10.1152/physiol.00035.2004.
- Noble PW, Homer RJ. Idiopathic pulmonary fibrosis: new insights into pathogenesis. Clinics In Chest Medicine 2004, 25: 749-58, vii. PMID: 15564020, DOI: 10.1016/j.ccm.2004.04.003.
- Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, Bhandari V, Kang MJ, Cohn L, Kim YK, McDonald DM, Elias JA. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nature Medicine 2004, 10: 1095-103. PMID: 15378055, PMCID: PMC3434232, DOI: 10.1038/nm1105.
- Kawikova I, Paliwal V, Szczepanik M, Itakura A, Fukui M, Campos RA, Geba GP, Homer RJ, Iliopoulou BP, Pober JS, Tsuji RF, Askenase PW. Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma. Immunology 2004, 113: 234-45. PMID: 15379984, PMCID: PMC1782564, DOI: 10.1111/j.1365-2567.2004.01936.x.
- Lee CG, Cho SJ, Kang MJ, Chapoval SP, Lee PJ, Noble PW, Yehualaeshet T, Lu B, Flavell RA, Milbrandt J, Homer RJ, Elias JA. Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. The Journal Of Experimental Medicine 2004, 200: 377-89. PMID: 15289506, PMCID: PMC2211975, DOI: 10.1084/jem.20040104.
- Jiang D, Liang J, Hodge J, Lu B, Zhu Z, Yu S, Fan J, Gao Y, Yin Z, Homer R, Gerard C, Noble PW. Regulation of pulmonary fibrosis by chemokine receptor CXCR3. The Journal Of Clinical Investigation 2004, 114: 291-9. PMID: 15254596, PMCID: PMC449741, DOI: 10.1172/JCI16861.
- Zhu Z, Zheng T, Homer RJ, Kim YK, Chen NY, Cohn L, Hamid Q, Elias JA. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science (New York, N.Y.) 2004, 304: 1678-82. PMID: 15192232, DOI: 10.1126/science.1095336.
- Severgnini M, Takahashi S, Rozo LM, Homer RJ, Kuhn C, Jhung JW, Perides G, Steer M, Hassoun PM, Fanburg BL, Cochran BH, Simon AR. Activation of the STAT pathway in acute lung injury. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2004, 286: L1282-92. PMID: 14729509, DOI: 10.1152/ajplung.00349.2003.
- Ma B, Zhu Z, Homer RJ, Gerard C, Strieter R, Elias JA. The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling. Journal Of Immunology (Baltimore, Md. : 1950) 2004, 172: 1872-81. PMID: 14734772, DOI: 10.4049/jimmunol.172.3.1872.
- Wang J, Chen Q, Corne J, Zhu Z, Lee CG, Bhandari V, Homer RJ, Elias JA. Pulmonary expression of leukemia inhibitory factor induces B cell hyperplasia and confers protection in hyperoxia. The Journal Of Biological Chemistry 2003, 278: 31226-32. PMID: 12782633, DOI: 10.1074/jbc.M301820200.
- Zheng T, Zhu Z, Liu W, Lee CG, Chen Q, Homer RJ, Elias JA. Cytokine regulation of IL-13Ralpha2 and IL-13Ralpha1 in vivo and in vitro. The Journal Of Allergy And Clinical Immunology 2003, 111: 720-8. PMID: 12704349, DOI: 10.1067/mai.2003.1383.
- Zhu Z, Enhorning G, Zheng T, Chen Q, Chen NY, Homer R, Elias JA. Interleukin-13 induces surfactant function abnormality in the murine lung. Chest 2003, 123: 375S-6S. PMID: 12628990.
- Elias JA, Zheng T, Lee CG, Homer RJ, Chen Q, Ma B, Blackburn M, Zhu Z. Transgenic modeling of interleukin-13 in the lung. Chest 2003, 123: 339S-45S. PMID: 12628967.
- Elias JA, Lee CG, Zheng T, Ma B, Homer RJ, Zhu Z. New insights into the pathogenesis of asthma. The Journal Of Clinical Investigation 2003, 111: 291-7. PMID: 12569150, PMCID: PMC151878, DOI: 10.1172/JCI17748.
- Whittaker L, Niu N, Temann UA, Stoddard A, Flavell RA, Ray A, Homer RJ, Cohn L. Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9. American Journal Of Respiratory Cell And Molecular Biology 2002, 27: 593-602. PMID: 12397019, DOI: 10.1165/rcmb.4838.
- Lee CG, Homer RJ, Cohn L, Link H, Jung S, Craft JE, Graham BS, Johnson TR, Elias JA. Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways. The Journal Of Biological Chemistry 2002, 277: 35466-74. PMID: 12107190, DOI: 10.1074/jbc.M206395200.
- Lanone S, Zheng T, Zhu Z, Liu W, Lee CG, Ma B, Chen Q, Homer RJ, Wang J, Rabach LA, Rabach ME, Shipley JM, Shapiro SD, Senior RM, Elias JA. Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling. The Journal Of Clinical Investigation 2002, 110: 463-74. PMID: 12189240, PMCID: PMC150413, DOI: 10.1172/JCI14136.
- Homer RJ, Zheng T, Chupp G, He S, Zhu Z, Chen Q, Ma B, Hite RD, Gobran LI, Rooney SA, Elias JA. Pulmonary type II cell hypertrophy and pulmonary lipoproteinosis are features of chronic IL-13 exposure. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2002, 283: L52-9. PMID: 12060560, DOI: 10.1152/ajplung.00438.2001.
- Zhu Z, Zheng T, Lee CG, Homer RJ, Elias JA. Tetracycline-controlled transcriptional regulation systems: advances and application in transgenic animal modeling. Seminars In Cell & Developmental Biology 2002, 13: 121-8. PMID: 12127145, DOI: 10.1016/s1084-9521(02)00018-6.
- Zhu Z, Ma B, Zheng T, Homer RJ, Lee CG, Charo IF, Noble P, Elias JA. IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling. Journal Of Immunology (Baltimore, Md. : 1950) 2002, 168: 2953-62. PMID: 11884467, DOI: 10.4049/jimmunol.168.6.2953.
- Cohn L, Whittaker L, Niu N, Homer RJ. Cytokine regulation of mucus production in a model of allergic asthma. Novartis Foundation Symposium 2002, 248: 201-13; discussion 213-20, 277-82. PMID: 12568496.
- Zhu Z, Lee CG, Zheng T, Chupp G, Wang J, Homer RJ, Noble PW, Hamid Q, Elias JA. Airway inflammation and remodeling in asthma. Lessons from interleukin 11 and interleukin 13 transgenic mice. American Journal Of Respiratory And Critical Care Medicine 2001, 164: S67-70. PMID: 11734470, DOI: 10.1164/ajrccm.164.supplement_2.2106070.
- Zheng T, Zhu Z, Wang J, Homer RJ, Elias JA. IL-11: insights in asthma from overexpression transgenic modeling. The Journal Of Allergy And Clinical Immunology 2001, 108: 489-96. PMID: 11590369, DOI: 10.1067/mai.2001.118510.
- Lee CG, Homer RJ, Zhu Z, Lanone S, Wang X, Koteliansky V, Shipley JM, Gotwals P, Noble P, Chen Q, Senior RM, Elias JA. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). The Journal Of Experimental Medicine 2001, 194: 809-21. PMID: 11560996, PMCID: PMC2195954, DOI: 10.1084/jem.194.6.809.
- Zhu Z, Ma B, Homer RJ, Zheng T, Elias JA. Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice. The Journal Of Biological Chemistry 2001, 276: 25222-9. PMID: 11331286, DOI: 10.1074/jbc.M101512200.
- Cohn L, Herrick C, Niu N, Homer R, Bottomly K. IL-4 promotes airway eosinophilia by suppressing IFN-gamma production: defining a novel role for IFN-gamma in the regulation of allergic airway inflammation. Journal Of Immunology (Baltimore, Md. : 1950) 2001, 166: 2760-7. PMID: 11160342, DOI: 10.4049/jimmunol.166.4.2760.
- Wang Z, Zheng T, Zhu Z, Homer RJ, Riese RJ, Chapman HA, Shapiro SD, Elias JA. Interferon gamma induction of pulmonary emphysema in the adult murine lung. The Journal Of Experimental Medicine 2000, 192: 1587-600. PMID: 11104801, PMCID: PMC2193095, DOI: 10.1084/jem.192.11.1587.
- Zheng T, Zhu Z, Wang Z, Homer RJ, Ma B, Riese RJ, Chapman HA, Shapiro SD, Elias JA. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. The Journal Of Clinical Investigation 2000, 106: 1081-93. PMID: 11067861, PMCID: PMC301418, DOI: 10.1172/JCI10458.
- Wang J, Homer RJ, Chen Q, Elias JA. Endogenous and exogenous IL-6 inhibit aeroallergen-induced Th2 inflammation. Journal Of Immunology (Baltimore, Md. : 1950) 2000, 165: 4051-61. PMID: 11034416, DOI: 10.4049/jimmunol.165.7.4051.
- Corne J, Chupp G, Lee CG, Homer RJ, Zhu Z, Chen Q, Ma B, Du Y, Roux F, McArdle J, Waxman AB, Elias JA. IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury. The Journal Of Clinical Investigation 2000, 106: 783-91. PMID: 10995789, PMCID: PMC381393, DOI: 10.1172/JCI9674.
- Wang J, Homer RJ, Hong L, Cohn L, Lee CG, Jung S, Elias JA. IL-11 selectively inhibits aeroallergen-induced pulmonary eosinophilia and Th2 cytokine production. Journal Of Immunology (Baltimore, Md. : 1950) 2000, 165: 2222-31. PMID: 10925310, DOI: 10.4049/jimmunol.165.4.2222.
- Jain D, Sarode VR, Abdul-Karim FW, Homer R, Robert ME. Evidence for the neoplastic transformation of Von-Meyenburg complexes. The American Journal Of Surgical Pathology 2000, 24: 1131-9. PMID: 10935654, DOI: 10.1097/00000478-200008000-00011.
- Powsner SM, Costa J, Homer RJ. Clinicians are from Mars and pathologists are from Venus. Archives Of Pathology & Laboratory Medicine 2000, 124: 1040-6. PMID: 10888781, DOI: 10.1043/0003-9985(2000)124<1040:CAFMAP>2.0.CO;2.
- Homer RJ, Elias JA. Consequences of long-term inflammation. Airway remodeling. Clinics In Chest Medicine 2000, 21: 331-43, ix. PMID: 10907592, DOI: 10.1016/s0272-5231(05)70270-7.
- Ward NS, Waxman AB, Homer RJ, Mantell LL, Einarsson O, Du Y, Elias JA. Interleukin-6-induced protection in hyperoxic acute lung injury. American Journal Of Respiratory Cell And Molecular Biology 2000, 22: 535-42. PMID: 10783124, DOI: 10.1165/ajrcmb.22.5.3808.
- Kuhn C, Homer RJ, Zhu Z, Ward N, Elias JA. Morphometry explains variation in airway responsiveness in transgenic mice overexpressing interleukin-6 and interleukin-11 in the lung. Chest 2000, 117: 260S-2S. PMID: 10843940.
- Kuhn C, Homer RJ, Zhu Z, Ward N, Flavell RA, Geba GP, Elias JA. Airway hyperresponsiveness and airway obstruction in transgenic mice. Morphologic correlates in mice overexpressing interleukin (IL)-11 and IL-6 in the lung. American Journal Of Respiratory Cell And Molecular Biology 2000, 22: 289-95. PMID: 10696065, DOI: 10.1165/ajrcmb.22.3.3690.
- Cohn L, Homer RJ, Niu N, Bottomly K. T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production. The Journal Of Experimental Medicine 1999, 190: 1309-18. PMID: 10544202, PMCID: PMC2195688, DOI: 10.1084/jem.190.9.1309.
- Zhang DH, Yang L, Cohn L, Parkyn L, Homer R, Ray P, Ray A. Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3. Immunity 1999, 11: 473-82. PMID: 10549629.
- Elias JA, Zhu Z, Chupp G, Homer RJ. Airway remodeling in asthma. The Journal Of Clinical Investigation 1999, 104: 1001-6. PMID: 10525034, PMCID: PMC408860, DOI: 10.1172/JCI8124.
- Waxman AB, Einarsson O, Seres T, Knickelbein RG, Homer R, Warshaw JB, Johnston R, Elias JA. Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation. Chest 1999, 116: 8S-9S. PMID: 10424559, DOI: 10.1378/chest.116.suppl_1.8s.
- Bromberg ME, Sundaram R, Homer RJ, Garen A, Konigsberg WH. Role of tissue factor in metastasis: functions of the cytoplasmic and extracellular domains of the molecule. Thrombosis And Haemostasis 1999, 82: 88-92. PMID: 10456459.
- Cohn L, Homer RJ, MacLeod H, Mohrs M, Brombacher F, Bottomly K. Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils. Journal Of Immunology (Baltimore, Md. : 1950) 1999, 162: 6178-83. PMID: 10229862.
- Zhu Z, Homer RJ, Wang Z, Chen Q, Geba GP, Wang J, Zhang Y, Elias JA. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. The Journal Of Clinical Investigation 1999, 103: 779-88. PMID: 10079098, PMCID: PMC408149, DOI: 10.1172/JCI5909.
- Homer RJ. Antineutrophil cytoplasmic antibodies as markers for systemic autoimmune disease. Clinics In Chest Medicine 1998, 19: 627-39, viii. PMID: 9917957, DOI: 10.1016/s0272-5231(05)70107-6.
- Yang L, Cohn L, Zhang DH, Homer R, Ray A, Ray P. Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation. The Journal Of Experimental Medicine 1998, 188: 1739-50. PMID: 9802985, PMCID: PMC2212522, DOI: 10.1084/jem.188.9.1739.
- Waxman AB, Einarsson O, Seres T, Knickelbein RG, Warshaw JB, Johnston R, Homer RJ, Elias JA. Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation. The Journal Of Clinical Investigation 1998, 101: 1970-82. PMID: 9576762, PMCID: PMC508784, DOI: 10.1172/JCI1337.
- Panzini L, Homer RJ. Duodenal hemangioendothelioma: a case report. The American Journal Of Gastroenterology 1998, 93: 832-3. PMID: 9625139, DOI: 10.1111/j.1572-0241.1998.236_a.x.
- Cohn L, Homer RJ, Marinov A, Rankin J, Bottomly K. Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. The Journal Of Experimental Medicine 1997, 186: 1737-47. PMID: 9362533, PMCID: PMC2199146, DOI: 10.1084/jem.186.10.1737.
- Ray P, Tang W, Wang P, Homer R, Kuhn C, Flavell RA, Elias JA. Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes. The Journal Of Clinical Investigation 1997, 100: 2501-11. PMID: 9366564, PMCID: PMC508450, DOI: 10.1172/JCI119792.
- Trawick D, Kotch A, Matthay R, Homer RJ. Eosinophilic pneumonia as a presentation of occult chronic granulomatous disease. The European Respiratory Journal 1997, 10: 2166-70. PMID: 9311521, DOI: 10.1183/09031936.97.10092166.
- Redlich CA, Karol MH, Graham C, Homer RJ, Holm CT, Wirth JA, Cullen MR. Airway isocyanate-adducts in asthma induced by exposure to hexamethylene diisocyanate. Scandinavian Journal Of Work, Environment & Health 1997, 23: 227-31. PMID: 9243734, DOI: 10.5271/sjweh.203.
- Tang W, Geba GP, Zheng T, Ray P, Homer RJ, Kuhn C, Flavell RA, Elias JA. Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction. The Journal Of Clinical Investigation 1996, 98: 2845-53. PMID: 8981933, PMCID: PMC507752, DOI: 10.1172/JCI119113.
- Redlich CA, Homer RJ, Smith BR, Wirth JA, Cullen MR. Immunologic responses to isocyanates in sensitized asthmatic subjects. Chest 1996, 109: 6S-8S. PMID: 8598159.
- Homer RJ, Khoo L, Smith GJ. Diffuse panbronchiolitis in a Hispanic man with travel history to Japan. Chest 1995, 107: 1176-8. PMID: 7705137, DOI: 10.1378/chest.107.4.1176.
- Homer RJ. Hubert Humphrey's bladder cancer. The New England Journal Of Medicine 1994, 331: 880; author reply 880-1. PMID: 8078544.
- Azrin MA, Ling FS, Chen Q, Pawashe A, Migliaccio F, Homer R, Todd M, Ezekowitz MD. Preparation, characterization, and evaluation of a monoclonal antibody against the rabbit platelet glycoprotein IIb/IIIa in an experimental angioplasty model. Circulation Research 1994, 75: 268-77. PMID: 8033340.
- Homer RJ, Mamalaki C, Kioussis D, Flavell RA. T cell unresponsiveness correlates with quantitative TCR levels in a transgenic model. International Immunology 1993, 5: 1495-500. PMID: 7906139, DOI: 10.1093/intimm/5.12.1495.
- Ruddle NH, Homer R. The role of lymphotoxin in inflammation. Progress In Allergy 1988, 40: 162-82. PMID: 3281169.
- Homer RJ, Murphy DB. Qc-1, a novel Q-region-controlled CTL determinant expressed on B lymphocytes. Journal Of Immunology (Baltimore, Md. : 1950) 1987, 138: 4322-8. PMID: 2438340.
- Murphy DB, Horowitz MC, Homer RJ, Flood PM. Genetic, serological and functional analysis of I-J molecules. Immunological Reviews 1985, 83: 79-103. PMID: 3160653, DOI: 10.1111/j.1600-065x.1985.tb00471.x.