Yale Cardiac Surgery
Yale Physicians Building
800 Howard Avenue
New Haven, CT 06519
- Yale Cardiac SurgeryYale Physicians Building800 Howard AvenueNew Haven, CT 06519
Markus Krane, MD
Cardiac Surgery
Patient type treated
Child, Adult
Accepting new patients
Yes
Referral required
From patients or physicians
Board Certified in
Thoracic & Cardiac Surgery
Education & Training
- Deputy DirectorGerman Heart Center Munich, Technische Universität München (2021)
- temp. Deputy DirectorGerman Heart Center Munich, Technische Universität München (2016)
- ConsultantGerman Heart Center Munich, Technische Universität München (2015)
- FellowshipGerman Heart Center Munich, Technische Universität München (2015)
- Research FellowshipHarvard Medical School (2010)
- ResidencyGerman Heart Center Munich, Technische Universität München (2009)
- MDLudwig-Maximilians University, Munich, Germany (2004)
Languages Spoken
- English
- Deutsch (German)
Additional Information
Board Certifications
- Bavarian State Medical Board, Thoracic & Cardiac Surgery (2015)
Publications
- Querdel E, Reinsch M, Castro L, Köse D, Bähr A, Reich S, Geertz B, Ulmer B, Schulze M, Lemoine MD, Krause T, Lemme M, Sani J, Shibamiya A, Stüdemann T, Köhne M, Bibra CV, Hornaschewitz N, Pecha S, Nejahsie Y, Mannhardt I, Christ T, Reichenspurner H, Hansen A, Klymiuk N, Krane M, Kupatt C, Eschenhagen T, Weinberger F. Human Engineered Heart Tissue Patches Remuscularize the Injured Heart in a Dose-Dependent Manner. Circulation 2021, 143: 1991-2006. PMID: 33648345, PMCID: PMC8126500, DOI: 10.1161/CIRCULATIONAHA.120.047904.
- König KC, Lahm H, Dreßen M, Doppler SA, Eichhorn S, Beck N, Kraehschuetz K, Doll S, Holdenrieder S, Kastrati A, Lange R, Krane M. Aggrecan: a new biomarker for acute type A aortic dissection. Scientific Reports 2021, 11: 10371. PMID: 33990642, PMCID: PMC8121825, DOI: 10.1038/s41598-021-89653-y.
- Krane M, Wirth F, Boehm J, Lange R. Do we need to rethink treatment of aortic valve pathologies in younger patients? European Journal Of Cardio-thoracic Surgery : Official Journal Of The European Association For Cardio-thoracic Surgery 2021 PMID: 33899098, DOI: 10.1093/ejcts/ezab032.
- Deutsch O, Deisenhofer I, Koch-Buettner K, Lange R, Krane M. Need for permanent pacemaker implantation following implantation of the rapid deployment valve in combined procedures: a single centre cohort study. Journal Of Thoracic Disease 2021, 13: 2128-2136. PMID: 34012563, PMCID: PMC8107573, DOI: 10.21037/jtd-20-3120.
- Sideris K, Burri M, Prinzing A, Voss S, Krane M, Guenzinger R, Lange R, Voss B. Mitral valve repair with the edge-to-edge technique: A 20 years single-center experience. Journal Of Cardiac Surgery 2021, 36: 1298-1304. PMID: 33512725, DOI: 10.1111/jocs.15377.
- Hesse M, Bednarz R, Carls E, Becker C, Bondareva O, Lother A, Geisen C, Dreßen M, Krane M, Roell W, Hein L, Fleischmann BK, Gilsbach R. Proximity to injury, but neither number of nuclei nor ploidy define pathological adaptation and plasticity in cardiomyocytes. Journal Of Molecular And Cellular Cardiology 2021, 152: 95-104. PMID: 33290769, DOI: 10.1016/j.yjmcc.2020.11.012.
- Congenital heart disease risk loci identified by genome-wide association study in European patients.Lahm H, Jia M, Dreßen M, Wirth F, Puluca N, Gilsbach R, Keavney BD, Cleuziou J, Beck N, Bondareva O, Dzilic E, Burri M, König KC, Ziegelmüller JA, Abou-Ajram C, Neb I, Zhang Z, Doppler SA, Mastantuono E, Lichtner P, Eckstein G, Hörer J, Ewert P, Priest JR, Hein L, Lange R, Meitinger T, Cordell HJ, Müller-Myhsok B, Krane M. Congenital heart disease risk loci identified by genome-wide association study in European patients. The Journal Of Clinical Investigation 2021, 131 PMID: 33201861, PMCID: PMC7810487, DOI: 10.1172/JCI141837.
- Krane M, Boehm J, Prinzing A, Ziegelmueller J, Holfeld J, Lange R. Excellent Hemodynamic Performance After Aortic Valve Neocuspidization Using Autologous Pericardium. The Annals Of Thoracic Surgery 2021, 111: 126-133. PMID: 32540439, DOI: 10.1016/j.athoracsur.2020.04.108.
- Baehr A, Umansky KB, Bassat E, Jurisch V, Klett K, Bozoglu T, Hornaschewitz N, Solyanik O, Kain D, Ferraro B, Cohen-Rabi R, Krane M, Cyran C, Soehnlein O, Laugwitz KL, Hinkel R, Kupatt C, Tzahor E. Agrin Promotes Coordinated Therapeutic Processes Leading to Improved Cardiac Repair in Pigs. Circulation 2020, 142: 868-881. PMID: 32508131, DOI: 10.1161/CIRCULATIONAHA.119.045116.
- Prinzing A, Boehm J, Erlebach M, Sideris K, Lange R, Krane M. Comparison of outcomes following isolated repair of tricuspid versus bicuspid aortic valves. Journal Of Thoracic Disease 2020, 12: 3514-3523. PMID: 32802430, PMCID: PMC7399387, DOI: 10.21037/jtd-19-4193.
- Puluca N, Durmus NG, Lee S, Belbachir N, Galdos FX, Ogut MG, Gupta R, Hirano KI, Krane M, Lange R, Wu JC, Wu SM, Demirci U. Levitating Cells to Sort the Fit and the Fat. Advanced Biosystems 2020, 4: e1900300. PMID: 32352239, DOI: 10.1002/adbi.201900300.
- Hoelscher SC, Stich T, Diehm A, Lahm H, Dreßen M, Zhang Z, Neb I, Aherrahrou Z, Erdmann J, Schunkert H, Santamaria G, Cuda G, Gilsbach R, Hein L, Lange R, Hassel D, Krane M, Doppler SA. miR-128a Acts as a Regulator in Cardiac Development by Modulating Differentiation of Cardiac Progenitor Cell Populations. International Journal Of Molecular Sciences 2020, 21 PMID: 32050579, PMCID: PMC7038042, DOI: 10.3390/ijms21031158.
- Puluca N, Lee S, Doppler S, Münsterer A, Dreßen M, Krane M, Wu SM. Bioprinting Approaches to Engineering Vascularized 3D Cardiac Tissues. Current Cardiology Reports 2019, 21: 90. PMID: 31352612, PMCID: PMC7340624, DOI: 10.1007/s11886-019-1179-8.
- Lahm H, Dreßen M, Beck N, Doppler S, Deutsch MA, Matsushima S, Neb I, König KC, Sideris K, Voss S, Eschenbach L, Puluca N, Deisenhofer I, Doll S, Holdenrieder S, Mann M, Lange R, Krane M. Myosin binding protein H-like (MYBPHL): a promising biomarker to predict atrial damage. Scientific Reports 2019, 9: 9986. PMID: 31292467, PMCID: PMC6620353, DOI: 10.1038/s41598-019-46123-w.
- Eichhorn S, Reisinger T, Böhm J, Voss S, Doppler S, Lange R, Krane M. Development and validation of a measurement system for continuously monitoring postoperative reservoir levels. Australasian Physical & Engineering Sciences In Medicine / Supported By The Australasian College Of Physical Scientists In Medicine And The Australasian Association Of Physical Sciences In Medicine 2019, 42: 611-617. PMID: 30868479, DOI: 10.1007/s13246-019-00746-5.
- Rommel C, Rösner S, Lother A, Barg M, Schwaderer M, Gilsbach R, Bömicke T, Schnick T, Mayer S, Doll S, Hesse M, Kretz O, Stiller B, Neumann FJ, Mann M, Krane M, Fleischmann BK, Ravens U, Hein L. The Transcription Factor ETV1 Induces Atrial Remodeling and Arrhythmia. Circulation Research 2018, 123: 550-563. PMID: 29930145, DOI: 10.1161/CIRCRESAHA.118.313036.
- Reactivation of the Nkx2.5 cardiac enhancer after myocardial infarction does not presage myogenesis.Deutsch MA, Doppler SA, Li X, Lahm H, Santamaria G, Cuda G, Eichhorn S, Ratschiller T, Dzilic E, Dreßen M, Eckart A, Stark K, Massberg S, Bartels A, Rischpler C, Gilsbach R, Hein L, Fleischmann BK, Wu SM, Lange R, Krane M. Reactivation of the Nkx2.5 cardiac enhancer after myocardial infarction does not presage myogenesis. Cardiovascular Research 2018, 114: 1098-1114. PMID: 29579159, PMCID: PMC6279078, DOI: 10.1093/cvr/cvy069.
- Gilsbach R, Schwaderer M, Preissl S, Grüning BA, Kranzhöfer D, Schneider P, Nührenberg TG, Mulero-Navarro S, Weichenhan D, Braun C, Dreßen M, Jacobs AR, Lahm H, Doenst T, Backofen R, Krane M, Gelb BD, Hein L. Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo. Nature Communications 2018, 9: 391. PMID: 29374152, PMCID: PMC5786002, DOI: 10.1038/s41467-017-02762-z.
- Dzilic E, Lahm H, Dreßen M, Deutsch MA, Lange R, Wu SM, Krane M, Doppler SA. Genome Editing Redefines Precision Medicine in the Cardiovascular Field. Stem Cells International 2018, 2018: 4136473. PMID: 29731778, PMCID: PMC5872631, DOI: 10.1155/2018/4136473.
- Nothjunge S, Nührenberg TG, Grüning BA, Doppler SA, Preissl S, Schwaderer M, Rommel C, Krane M, Hein L, Gilsbach R. DNA methylation signatures follow preformed chromatin compartments in cardiac myocytes. Nature Communications 2017, 8: 1667. PMID: 29162810, PMCID: PMC5698409, DOI: 10.1038/s41467-017-01724-9.
- Doll S, Dreßen M, Geyer PE, Itzhak DN, Braun C, Doppler SA, Meier F, Deutsch MA, Lahm H, Lange R, Krane M, Mann M. Region and cell-type resolved quantitative proteomic map of the human heart. Nature Communications 2017, 8: 1469. PMID: 29133944, PMCID: PMC5684139, DOI: 10.1038/s41467-017-01747-2.
- Doppler SA, Deutsch MA, Serpooshan V, Li G, Dzilic E, Lange R, Krane M, Wu SM. Mammalian Heart Regeneration: The Race to the Finish Line. Circulation Research 2017, 120: 630-632. PMID: 28209796, PMCID: PMC5321648, DOI: 10.1161/CIRCRESAHA.116.310051.
- Eichhorn S, Mendoza A, Prinzing A, Stroh A, Xinghai L, Polski M, Heller M, Lahm H, Wolf E, Lange R, Krane M. Corpuls CPR Generates Higher Mean Arterial Pressure Than LUCAS II in a Pig Model of Cardiac Arrest. BioMed Research International 2017, 2017: 5470406. PMID: 29392137, PMCID: PMC5748132, DOI: 10.1155/2017/5470406.
- Dreßen M, Lahm H, Lahm A, Wolf K, Doppler S, Deutsch MA, Cleuziou J, Pabst von Ohain J, Schön P, Ewert P, Malcic I, Lange R, Krane M. A novel de novo TBX5 mutation in a patient with Holt-Oram syndrome leading to a dramatically reduced biological function. Molecular Genetics & Genomic Medicine 2016, 4: 557-67. PMID: 27652283, PMCID: PMC5023941, DOI: 10.1002/mgg3.234.
- Schuh E, Berer K, Mulazzani M, Feil K, Meinl I, Lahm H, Krane M, Lange R, Pfannes K, Subklewe M, Gürkov R, Bradl M, Hohlfeld R, Kümpfel T, Meinl E, Krumbholz M. Features of Human CD3+CD20+ T Cells. Journal Of Immunology (Baltimore, Md. : 1950) 2016, 197: 1111-7. PMID: 27412413, DOI: 10.4049/jimmunol.1600089.
- Lahm H, Doppler SA, Dreßen M, Adamczyk K, Deutsch MA, Ulrich H, Schiemann M, Lange R, Krane M. Detection of Intracellular Gene Expression in Live Cells of Murine, Human and Porcine Origin Using Fluorescence-labeled Nanoparticles. Journal Of Visualized Experiments : JoVE 2015 PMID: 26650934, PMCID: PMC4692708, DOI: 10.3791/53268.
- Ratschiller T, Deutsch MA, Calzada-Wack J, Neff F, Roesch C, Guenzinger R, Lange R, Krane M. Heterotopic Cervical Heart Transplantation in Mice. Journal Of Visualized Experiments : JoVE 2015, e52907. PMID: 26325193, PMCID: PMC4692555, DOI: 10.3791/52907.
- Doppler SA, Deutsch MA, Lange R, Krane M. Direct Reprogramming-The Future of Cardiac Regeneration? International Journal Of Molecular Sciences 2015, 16: 17368-93. PMID: 26230692, PMCID: PMC4581198, DOI: 10.3390/ijms160817368.
- Lahm H, Schön P, Doppler S, Dreßen M, Cleuziou J, Deutsch MA, Ewert P, Lange R, Krane M. Tetralogy of Fallot and Hypoplastic Left Heart Syndrome - Complex Clinical Phenotypes Meet Complex Genetic Networks. Current Genomics 2015, 16: 141-58. PMID: 26069455, PMCID: PMC4460219, DOI: 10.2174/1389202916666150303232520.
- Lahm H, Doppler S, Dreßen M, Werner A, Adamczyk K, Schrambke D, Brade T, Laugwitz KL, Deutsch MA, Schiemann M, Lange R, Moretti A, Krane M. Live fluorescent RNA-based detection of pluripotency gene expression in embryonic and induced pluripotent stem cells of different species. Stem Cells (Dayton, Ohio) 2015, 33: 392-402. PMID: 25335772, DOI: 10.1002/stem.1872.
- Krane M, Deutsch MA, Doppler S, Lange R, Wu SM. Small RNAs make big impact in cardiac repair. Circulation Research 2015, 116: 393-5. PMID: 25634967, PMCID: PMC4313563, DOI: 10.1161/CIRCRESAHA.114.305676.
- Doppler SA, Werner A, Barz M, Lahm H, Deutsch MA, Dreßen M, Schiemann M, Voss B, Gregoire S, Kuppusamy R, Wu SM, Lange R, Krane M. Myeloid zinc finger 1 (Mzf1) differentially modulates murine cardiogenesis by interacting with an Nkx2.5 cardiac enhancer. PloS One 2014, 9: e113775. PMID: 25436607, PMCID: PMC4249966, DOI: 10.1371/journal.pone.0113775.
- Lahm H, Deutsch MA, Dreßen M, Doppler S, Werner A, Hörer J, Cleuziou J, Schreiber C, Böhm J, Laugwitz KL, Lange R, Krane M. Mutational analysis of the human MESP1 gene in patients with congenital heart disease reveals a highly variable sequence in exon 1. European Journal Of Medical Genetics 2013, 56: 591-8. PMID: 24056064, DOI: 10.1016/j.ejmg.2013.09.001.
- Doppler SA, Deutsch MA, Lange R, Krane M. Cardiac regeneration: current therapies-future concepts. Journal Of Thoracic Disease 2013, 5: 683-97. PMID: 24255783, PMCID: PMC3815722, DOI: 10.3978/j.issn.2072-1439.2013.08.71.
- Gregoire S, Karra R, Passer D, Deutsch MA, Krane M, Feistritzer R, Sturzu A, Domian I, Saga Y, Wu SM. Essential and unexpected role of Yin Yang 1 to promote mesodermal cardiac differentiation. Circulation Research 2013, 112: 900-10. PMID: 23307821, PMCID: PMC3629954, DOI: 10.1161/CIRCRESAHA.113.259259.
- Chen JX, Krane M, Deutsch MA, Wang L, Rav-Acha M, Gregoire S, Engels MC, Rajarajan K, Karra R, Abel ED, Wu JC, Milan D, Wu SM. Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. Circulation Research 2012, 111: 50-5. PMID: 22581928, PMCID: PMC3390172, DOI: 10.1161/CIRCRESAHA.112.270264.
- Krane M, Deutsch MA, Piazza N, Muhtarova T, Elhmidi Y, Mazzitelli D, Voss B, Ruge H, Badiu CC, Kornek M, Bleiziffer S, Lange R. One-year results of health-related quality of life among patients undergoing transcatheter aortic valve implantation. The American Journal Of Cardiology 2012, 109: 1774-81. PMID: 22520622, DOI: 10.1016/j.amjcard.2012.02.021.
- Dummler S, Eichhorn S, Tesche C, Schreiber U, Voss B, Deutsch MA, Hauner H, Lahm H, Lange R, Krane M. Pulsatile ex vivo perfusion of human saphenous vein grafts under controlled pressure conditions increases MMP-2 expression. Biomedical Engineering Online 2011, 10: 62. PMID: 21777461, PMCID: PMC3148203, DOI: 10.1186/1475-925X-10-62.
- Krane M, Dummler S, Dreßen M, Hauner H, Hoffmann M, Haller D, Heller K, Wildhirt S, Voss B, Grammer J, Lahm H, Lange R, Bauernschmitt R. Identification of an up-regulated anti-apoptotic network in the internal thoracic artery. International Journal Of Cardiology 2011, 149: 221-226. PMID: 20207035, DOI: 10.1016/j.ijcard.2010.02.003.
- Krane M, Voss B, Hiebinger A, Deutsch MA, Wottke M, Hapfelmeier A, Badiu CC, Bauernschmitt R, Lange R. Twenty years of cardiac surgery in patients aged 80 years and older: risks and benefits. The Annals Of Thoracic Surgery 2011, 91: 506-13. PMID: 21256302, DOI: 10.1016/j.athoracsur.2010.10.041.
- Krane M, Deutsch MA, Bleiziffer S, Schneider L, Ruge H, Mazzitelli D, Schreiber C, Brockmann G, Voss B, Bauernschmitt R, Lange R. Quality of life among patients undergoing transcatheter aortic valve implantation. American Heart Journal 2010, 160: 451-7. PMID: 20826252, DOI: 10.1016/j.ahj.2010.05.038.
- Krane M, Wernet O, Wu SM. Promises and pitfalls in cell replacement therapy for heart failure. Drug Discovery Today. Disease Mechanisms 2010, 7: e109-e115. PMID: 21180399, PMCID: PMC3003923, DOI: 10.1016/j.ddmec.2010.07.004.
- Krane M, Mazzitelli D, Schreiber U, Garzia AM, Braun S, Voss B, Badiu CC, Brockmann G, Lange R, Bauernschmitt R. LIFEBRIDGE B2T--a new portable cardiopulmonary bypass system. ASAIO Journal (American Society For Artificial Internal Organs : 1992) 2010, 56: 52-6. PMID: 20051839, DOI: 10.1097/MAT.0b013e3181c1d84a.
- Krane M, Bauernschmitt R, Hiebinger A, Wottke M, Voss B, Badiu CC, Lange R. Cardiac reoperation in patients aged 80 years and older. The Annals Of Thoracic Surgery 2009, 87: 1379-85. PMID: 19379868, DOI: 10.1016/j.athoracsur.2009.01.045.
- Krane M, Griese M. Surfactant protein D in serum from patients with allergic bronchopulmonary aspergillosis. The European Respiratory Journal 2003, 22: 592-5. PMID: 14582909, DOI: 10.1183/09031936.03.00060603.
Departments and Programs
Locations
Yale Cardiac Surgery
Yale Physicians Building
800 Howard Avenue
New Haven, CT 06519
- Yale Cardiac SurgeryYale Physicians Building800 Howard AvenueNew Haven, CT 06519
Education & Training
- Deputy DirectorGerman Heart Center Munich, Technische Universität München (2021)
- temp. Deputy DirectorGerman Heart Center Munich, Technische Universität München (2016)
- ConsultantGerman Heart Center Munich, Technische Universität München (2015)
- FellowshipGerman Heart Center Munich, Technische Universität München (2015)
- Research FellowshipHarvard Medical School (2010)
- ResidencyGerman Heart Center Munich, Technische Universität München (2009)
- MDLudwig-Maximilians University, Munich, Germany (2004)
Languages Spoken
- English
- Deutsch (German)
Additional Information
Board Certifications
- Bavarian State Medical Board, Thoracic & Cardiac Surgery (2015)
Publications
- Querdel E, Reinsch M, Castro L, Köse D, Bähr A, Reich S, Geertz B, Ulmer B, Schulze M, Lemoine MD, Krause T, Lemme M, Sani J, Shibamiya A, Stüdemann T, Köhne M, Bibra CV, Hornaschewitz N, Pecha S, Nejahsie Y, Mannhardt I, Christ T, Reichenspurner H, Hansen A, Klymiuk N, Krane M, Kupatt C, Eschenhagen T, Weinberger F. Human Engineered Heart Tissue Patches Remuscularize the Injured Heart in a Dose-Dependent Manner. Circulation 2021, 143: 1991-2006. PMID: 33648345, PMCID: PMC8126500, DOI: 10.1161/CIRCULATIONAHA.120.047904.
- König KC, Lahm H, Dreßen M, Doppler SA, Eichhorn S, Beck N, Kraehschuetz K, Doll S, Holdenrieder S, Kastrati A, Lange R, Krane M. Aggrecan: a new biomarker for acute type A aortic dissection. Scientific Reports 2021, 11: 10371. PMID: 33990642, PMCID: PMC8121825, DOI: 10.1038/s41598-021-89653-y.
- Krane M, Wirth F, Boehm J, Lange R. Do we need to rethink treatment of aortic valve pathologies in younger patients? European Journal Of Cardio-thoracic Surgery : Official Journal Of The European Association For Cardio-thoracic Surgery 2021 PMID: 33899098, DOI: 10.1093/ejcts/ezab032.
- Deutsch O, Deisenhofer I, Koch-Buettner K, Lange R, Krane M. Need for permanent pacemaker implantation following implantation of the rapid deployment valve in combined procedures: a single centre cohort study. Journal Of Thoracic Disease 2021, 13: 2128-2136. PMID: 34012563, PMCID: PMC8107573, DOI: 10.21037/jtd-20-3120.
- Sideris K, Burri M, Prinzing A, Voss S, Krane M, Guenzinger R, Lange R, Voss B. Mitral valve repair with the edge-to-edge technique: A 20 years single-center experience. Journal Of Cardiac Surgery 2021, 36: 1298-1304. PMID: 33512725, DOI: 10.1111/jocs.15377.
- Hesse M, Bednarz R, Carls E, Becker C, Bondareva O, Lother A, Geisen C, Dreßen M, Krane M, Roell W, Hein L, Fleischmann BK, Gilsbach R. Proximity to injury, but neither number of nuclei nor ploidy define pathological adaptation and plasticity in cardiomyocytes. Journal Of Molecular And Cellular Cardiology 2021, 152: 95-104. PMID: 33290769, DOI: 10.1016/j.yjmcc.2020.11.012.
- Congenital heart disease risk loci identified by genome-wide association study in European patients.Lahm H, Jia M, Dreßen M, Wirth F, Puluca N, Gilsbach R, Keavney BD, Cleuziou J, Beck N, Bondareva O, Dzilic E, Burri M, König KC, Ziegelmüller JA, Abou-Ajram C, Neb I, Zhang Z, Doppler SA, Mastantuono E, Lichtner P, Eckstein G, Hörer J, Ewert P, Priest JR, Hein L, Lange R, Meitinger T, Cordell HJ, Müller-Myhsok B, Krane M. Congenital heart disease risk loci identified by genome-wide association study in European patients. The Journal Of Clinical Investigation 2021, 131 PMID: 33201861, PMCID: PMC7810487, DOI: 10.1172/JCI141837.
- Krane M, Boehm J, Prinzing A, Ziegelmueller J, Holfeld J, Lange R. Excellent Hemodynamic Performance After Aortic Valve Neocuspidization Using Autologous Pericardium. The Annals Of Thoracic Surgery 2021, 111: 126-133. PMID: 32540439, DOI: 10.1016/j.athoracsur.2020.04.108.
- Baehr A, Umansky KB, Bassat E, Jurisch V, Klett K, Bozoglu T, Hornaschewitz N, Solyanik O, Kain D, Ferraro B, Cohen-Rabi R, Krane M, Cyran C, Soehnlein O, Laugwitz KL, Hinkel R, Kupatt C, Tzahor E. Agrin Promotes Coordinated Therapeutic Processes Leading to Improved Cardiac Repair in Pigs. Circulation 2020, 142: 868-881. PMID: 32508131, DOI: 10.1161/CIRCULATIONAHA.119.045116.
- Prinzing A, Boehm J, Erlebach M, Sideris K, Lange R, Krane M. Comparison of outcomes following isolated repair of tricuspid versus bicuspid aortic valves. Journal Of Thoracic Disease 2020, 12: 3514-3523. PMID: 32802430, PMCID: PMC7399387, DOI: 10.21037/jtd-19-4193.
- Puluca N, Durmus NG, Lee S, Belbachir N, Galdos FX, Ogut MG, Gupta R, Hirano KI, Krane M, Lange R, Wu JC, Wu SM, Demirci U. Levitating Cells to Sort the Fit and the Fat. Advanced Biosystems 2020, 4: e1900300. PMID: 32352239, DOI: 10.1002/adbi.201900300.
- Hoelscher SC, Stich T, Diehm A, Lahm H, Dreßen M, Zhang Z, Neb I, Aherrahrou Z, Erdmann J, Schunkert H, Santamaria G, Cuda G, Gilsbach R, Hein L, Lange R, Hassel D, Krane M, Doppler SA. miR-128a Acts as a Regulator in Cardiac Development by Modulating Differentiation of Cardiac Progenitor Cell Populations. International Journal Of Molecular Sciences 2020, 21 PMID: 32050579, PMCID: PMC7038042, DOI: 10.3390/ijms21031158.
- Puluca N, Lee S, Doppler S, Münsterer A, Dreßen M, Krane M, Wu SM. Bioprinting Approaches to Engineering Vascularized 3D Cardiac Tissues. Current Cardiology Reports 2019, 21: 90. PMID: 31352612, PMCID: PMC7340624, DOI: 10.1007/s11886-019-1179-8.
- Lahm H, Dreßen M, Beck N, Doppler S, Deutsch MA, Matsushima S, Neb I, König KC, Sideris K, Voss S, Eschenbach L, Puluca N, Deisenhofer I, Doll S, Holdenrieder S, Mann M, Lange R, Krane M. Myosin binding protein H-like (MYBPHL): a promising biomarker to predict atrial damage. Scientific Reports 2019, 9: 9986. PMID: 31292467, PMCID: PMC6620353, DOI: 10.1038/s41598-019-46123-w.
- Eichhorn S, Reisinger T, Böhm J, Voss S, Doppler S, Lange R, Krane M. Development and validation of a measurement system for continuously monitoring postoperative reservoir levels. Australasian Physical & Engineering Sciences In Medicine / Supported By The Australasian College Of Physical Scientists In Medicine And The Australasian Association Of Physical Sciences In Medicine 2019, 42: 611-617. PMID: 30868479, DOI: 10.1007/s13246-019-00746-5.
- Rommel C, Rösner S, Lother A, Barg M, Schwaderer M, Gilsbach R, Bömicke T, Schnick T, Mayer S, Doll S, Hesse M, Kretz O, Stiller B, Neumann FJ, Mann M, Krane M, Fleischmann BK, Ravens U, Hein L. The Transcription Factor ETV1 Induces Atrial Remodeling and Arrhythmia. Circulation Research 2018, 123: 550-563. PMID: 29930145, DOI: 10.1161/CIRCRESAHA.118.313036.
- Reactivation of the Nkx2.5 cardiac enhancer after myocardial infarction does not presage myogenesis.Deutsch MA, Doppler SA, Li X, Lahm H, Santamaria G, Cuda G, Eichhorn S, Ratschiller T, Dzilic E, Dreßen M, Eckart A, Stark K, Massberg S, Bartels A, Rischpler C, Gilsbach R, Hein L, Fleischmann BK, Wu SM, Lange R, Krane M. Reactivation of the Nkx2.5 cardiac enhancer after myocardial infarction does not presage myogenesis. Cardiovascular Research 2018, 114: 1098-1114. PMID: 29579159, PMCID: PMC6279078, DOI: 10.1093/cvr/cvy069.
- Gilsbach R, Schwaderer M, Preissl S, Grüning BA, Kranzhöfer D, Schneider P, Nührenberg TG, Mulero-Navarro S, Weichenhan D, Braun C, Dreßen M, Jacobs AR, Lahm H, Doenst T, Backofen R, Krane M, Gelb BD, Hein L. Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo. Nature Communications 2018, 9: 391. PMID: 29374152, PMCID: PMC5786002, DOI: 10.1038/s41467-017-02762-z.
- Dzilic E, Lahm H, Dreßen M, Deutsch MA, Lange R, Wu SM, Krane M, Doppler SA. Genome Editing Redefines Precision Medicine in the Cardiovascular Field. Stem Cells International 2018, 2018: 4136473. PMID: 29731778, PMCID: PMC5872631, DOI: 10.1155/2018/4136473.
- Nothjunge S, Nührenberg TG, Grüning BA, Doppler SA, Preissl S, Schwaderer M, Rommel C, Krane M, Hein L, Gilsbach R. DNA methylation signatures follow preformed chromatin compartments in cardiac myocytes. Nature Communications 2017, 8: 1667. PMID: 29162810, PMCID: PMC5698409, DOI: 10.1038/s41467-017-01724-9.
- Doll S, Dreßen M, Geyer PE, Itzhak DN, Braun C, Doppler SA, Meier F, Deutsch MA, Lahm H, Lange R, Krane M, Mann M. Region and cell-type resolved quantitative proteomic map of the human heart. Nature Communications 2017, 8: 1469. PMID: 29133944, PMCID: PMC5684139, DOI: 10.1038/s41467-017-01747-2.
- Doppler SA, Deutsch MA, Serpooshan V, Li G, Dzilic E, Lange R, Krane M, Wu SM. Mammalian Heart Regeneration: The Race to the Finish Line. Circulation Research 2017, 120: 630-632. PMID: 28209796, PMCID: PMC5321648, DOI: 10.1161/CIRCRESAHA.116.310051.
- Eichhorn S, Mendoza A, Prinzing A, Stroh A, Xinghai L, Polski M, Heller M, Lahm H, Wolf E, Lange R, Krane M. Corpuls CPR Generates Higher Mean Arterial Pressure Than LUCAS II in a Pig Model of Cardiac Arrest. BioMed Research International 2017, 2017: 5470406. PMID: 29392137, PMCID: PMC5748132, DOI: 10.1155/2017/5470406.
- Dreßen M, Lahm H, Lahm A, Wolf K, Doppler S, Deutsch MA, Cleuziou J, Pabst von Ohain J, Schön P, Ewert P, Malcic I, Lange R, Krane M. A novel de novo TBX5 mutation in a patient with Holt-Oram syndrome leading to a dramatically reduced biological function. Molecular Genetics & Genomic Medicine 2016, 4: 557-67. PMID: 27652283, PMCID: PMC5023941, DOI: 10.1002/mgg3.234.
- Schuh E, Berer K, Mulazzani M, Feil K, Meinl I, Lahm H, Krane M, Lange R, Pfannes K, Subklewe M, Gürkov R, Bradl M, Hohlfeld R, Kümpfel T, Meinl E, Krumbholz M. Features of Human CD3+CD20+ T Cells. Journal Of Immunology (Baltimore, Md. : 1950) 2016, 197: 1111-7. PMID: 27412413, DOI: 10.4049/jimmunol.1600089.
- Lahm H, Doppler SA, Dreßen M, Adamczyk K, Deutsch MA, Ulrich H, Schiemann M, Lange R, Krane M. Detection of Intracellular Gene Expression in Live Cells of Murine, Human and Porcine Origin Using Fluorescence-labeled Nanoparticles. Journal Of Visualized Experiments : JoVE 2015 PMID: 26650934, PMCID: PMC4692708, DOI: 10.3791/53268.
- Ratschiller T, Deutsch MA, Calzada-Wack J, Neff F, Roesch C, Guenzinger R, Lange R, Krane M. Heterotopic Cervical Heart Transplantation in Mice. Journal Of Visualized Experiments : JoVE 2015, e52907. PMID: 26325193, PMCID: PMC4692555, DOI: 10.3791/52907.
- Doppler SA, Deutsch MA, Lange R, Krane M. Direct Reprogramming-The Future of Cardiac Regeneration? International Journal Of Molecular Sciences 2015, 16: 17368-93. PMID: 26230692, PMCID: PMC4581198, DOI: 10.3390/ijms160817368.
- Lahm H, Schön P, Doppler S, Dreßen M, Cleuziou J, Deutsch MA, Ewert P, Lange R, Krane M. Tetralogy of Fallot and Hypoplastic Left Heart Syndrome - Complex Clinical Phenotypes Meet Complex Genetic Networks. Current Genomics 2015, 16: 141-58. PMID: 26069455, PMCID: PMC4460219, DOI: 10.2174/1389202916666150303232520.
- Lahm H, Doppler S, Dreßen M, Werner A, Adamczyk K, Schrambke D, Brade T, Laugwitz KL, Deutsch MA, Schiemann M, Lange R, Moretti A, Krane M. Live fluorescent RNA-based detection of pluripotency gene expression in embryonic and induced pluripotent stem cells of different species. Stem Cells (Dayton, Ohio) 2015, 33: 392-402. PMID: 25335772, DOI: 10.1002/stem.1872.
- Krane M, Deutsch MA, Doppler S, Lange R, Wu SM. Small RNAs make big impact in cardiac repair. Circulation Research 2015, 116: 393-5. PMID: 25634967, PMCID: PMC4313563, DOI: 10.1161/CIRCRESAHA.114.305676.
- Doppler SA, Werner A, Barz M, Lahm H, Deutsch MA, Dreßen M, Schiemann M, Voss B, Gregoire S, Kuppusamy R, Wu SM, Lange R, Krane M. Myeloid zinc finger 1 (Mzf1) differentially modulates murine cardiogenesis by interacting with an Nkx2.5 cardiac enhancer. PloS One 2014, 9: e113775. PMID: 25436607, PMCID: PMC4249966, DOI: 10.1371/journal.pone.0113775.
- Lahm H, Deutsch MA, Dreßen M, Doppler S, Werner A, Hörer J, Cleuziou J, Schreiber C, Böhm J, Laugwitz KL, Lange R, Krane M. Mutational analysis of the human MESP1 gene in patients with congenital heart disease reveals a highly variable sequence in exon 1. European Journal Of Medical Genetics 2013, 56: 591-8. PMID: 24056064, DOI: 10.1016/j.ejmg.2013.09.001.
- Doppler SA, Deutsch MA, Lange R, Krane M. Cardiac regeneration: current therapies-future concepts. Journal Of Thoracic Disease 2013, 5: 683-97. PMID: 24255783, PMCID: PMC3815722, DOI: 10.3978/j.issn.2072-1439.2013.08.71.
- Gregoire S, Karra R, Passer D, Deutsch MA, Krane M, Feistritzer R, Sturzu A, Domian I, Saga Y, Wu SM. Essential and unexpected role of Yin Yang 1 to promote mesodermal cardiac differentiation. Circulation Research 2013, 112: 900-10. PMID: 23307821, PMCID: PMC3629954, DOI: 10.1161/CIRCRESAHA.113.259259.
- Chen JX, Krane M, Deutsch MA, Wang L, Rav-Acha M, Gregoire S, Engels MC, Rajarajan K, Karra R, Abel ED, Wu JC, Milan D, Wu SM. Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. Circulation Research 2012, 111: 50-5. PMID: 22581928, PMCID: PMC3390172, DOI: 10.1161/CIRCRESAHA.112.270264.
- Krane M, Deutsch MA, Piazza N, Muhtarova T, Elhmidi Y, Mazzitelli D, Voss B, Ruge H, Badiu CC, Kornek M, Bleiziffer S, Lange R. One-year results of health-related quality of life among patients undergoing transcatheter aortic valve implantation. The American Journal Of Cardiology 2012, 109: 1774-81. PMID: 22520622, DOI: 10.1016/j.amjcard.2012.02.021.
- Dummler S, Eichhorn S, Tesche C, Schreiber U, Voss B, Deutsch MA, Hauner H, Lahm H, Lange R, Krane M. Pulsatile ex vivo perfusion of human saphenous vein grafts under controlled pressure conditions increases MMP-2 expression. Biomedical Engineering Online 2011, 10: 62. PMID: 21777461, PMCID: PMC3148203, DOI: 10.1186/1475-925X-10-62.
- Krane M, Dummler S, Dreßen M, Hauner H, Hoffmann M, Haller D, Heller K, Wildhirt S, Voss B, Grammer J, Lahm H, Lange R, Bauernschmitt R. Identification of an up-regulated anti-apoptotic network in the internal thoracic artery. International Journal Of Cardiology 2011, 149: 221-226. PMID: 20207035, DOI: 10.1016/j.ijcard.2010.02.003.
- Krane M, Voss B, Hiebinger A, Deutsch MA, Wottke M, Hapfelmeier A, Badiu CC, Bauernschmitt R, Lange R. Twenty years of cardiac surgery in patients aged 80 years and older: risks and benefits. The Annals Of Thoracic Surgery 2011, 91: 506-13. PMID: 21256302, DOI: 10.1016/j.athoracsur.2010.10.041.
- Krane M, Deutsch MA, Bleiziffer S, Schneider L, Ruge H, Mazzitelli D, Schreiber C, Brockmann G, Voss B, Bauernschmitt R, Lange R. Quality of life among patients undergoing transcatheter aortic valve implantation. American Heart Journal 2010, 160: 451-7. PMID: 20826252, DOI: 10.1016/j.ahj.2010.05.038.
- Krane M, Wernet O, Wu SM. Promises and pitfalls in cell replacement therapy for heart failure. Drug Discovery Today. Disease Mechanisms 2010, 7: e109-e115. PMID: 21180399, PMCID: PMC3003923, DOI: 10.1016/j.ddmec.2010.07.004.
- Krane M, Mazzitelli D, Schreiber U, Garzia AM, Braun S, Voss B, Badiu CC, Brockmann G, Lange R, Bauernschmitt R. LIFEBRIDGE B2T--a new portable cardiopulmonary bypass system. ASAIO Journal (American Society For Artificial Internal Organs : 1992) 2010, 56: 52-6. PMID: 20051839, DOI: 10.1097/MAT.0b013e3181c1d84a.
- Krane M, Bauernschmitt R, Hiebinger A, Wottke M, Voss B, Badiu CC, Lange R. Cardiac reoperation in patients aged 80 years and older. The Annals Of Thoracic Surgery 2009, 87: 1379-85. PMID: 19379868, DOI: 10.1016/j.athoracsur.2009.01.045.
- Krane M, Griese M. Surfactant protein D in serum from patients with allergic bronchopulmonary aspergillosis. The European Respiratory Journal 2003, 22: 592-5. PMID: 14582909, DOI: 10.1183/09031936.03.00060603.
Departments and Programs
Locations
Yale Cardiac Surgery
Yale Physicians Building
800 Howard Avenue
New Haven, CT 06519
- Yale Cardiac SurgeryYale Physicians Building800 Howard AvenueNew Haven, CT 06519
Yale Cardiac Surgery
Yale Physicians Building
800 Howard Avenue
New Haven, CT 06519
- Yale Cardiac SurgeryYale Physicians Building800 Howard AvenueNew Haven, CT 06519