Yale Pediatric Respiratory Medicine
Yale New Haven Children's Hospital
1 Park Street, Ste West Pavilion - 2nd Floor
New Haven, CT 06504
- Yale Pediatric Respiratory MedicineYale New Haven Children's Hospital1 Park Street, Ste West Pavilion - 2nd FloorNew Haven, CT 06504
Marie Egan, MD
Pediatrics, Pediatric Pulmonology
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Patient type treated
Child
Accepting new patients
Yes
Referral required
From patients or physicians
Titles
- Professor of Pediatrics (Respiratory) and of Cellular And Molecular Physiology
- Director, Cystic Fibrosis Center
- Vice Chair for Research, Department of Pediatrics
Education & Training
- FellowThe Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins Hospital (1992)
- ResidentJohns Hopkins Hospital (1989)
- InternThe Johns Hopkins Hospital (1987)
- MDMount Sinai School of Medicine (1986)
Additional Information
Honors & Recognitions
- Hartwell Individual Biomedical Research Award: Hartwell Foundation (2011)
- Society of Pediatric Research, Membership Secretary: (2004)
- Society of Distinguished Teachers: Yale University School of Medicine (2002)
- The Leah Lowenstein Award, Faculty Teaching Award: Yale School of Medicine (2002)
Professional Service
- The Charles Hood Child Health Research Committee (2010 - Present): Reviewer
- (2008 - 2010): Brown-Coxe Review Committee
- (2008 - Present): Drug Monitoring Safety Board CF Foundation
- NIH (2008 - Present): Member
- (2007 - 2008): ATS Pediatric Assembly Nominating Committee Chairman
- Department of Pediatrics Faculty Development Committee
- MD/PhD Student Selection Committee
- Progress Committee, Yale University School of Medicine
- Cystic Fibrosis Foundation Research Review Committee
- FDA Orphan Disease Grant Review Program
Publications
- Di Pietro C, Öz HH, Zhang PX, Cheng EC, Martis V, Bonfield TL, Kelley TJ, Jubin R, Abuchowski A, Krause DS, Egan ME, Murray TS, Bruscia EM. Recruitment of monocytes primed to express heme oxygenase-1 ameliorates pathological lung inflammation in cystic fibrosis. Experimental & Molecular Medicine 2022, 54: 639-652. PMID: 35581352, PMCID: PMC9166813, DOI: 10.1038/s12276-022-00770-8.
- Luks VL, Mandl H, DiRito J, Barone C, Freedman-Weiss MR, Ricciardi AS, Tietjen GG, Egan ME, Saltzman WM, Stitelman DH. Surface conjugation of antibodies improves nanoparticle uptake in bronchial epithelial cells. PloS One 2022, 17: e0266218. PMID: 35385514, PMCID: PMC8986008, DOI: 10.1371/journal.pone.0266218.
- Khanal S, Webster M, Niu N, Zielonka J, Nunez M, Chupp G, Slade MD, Cohn L, Sauler M, Gomez JL, Tarran R, Sharma L, Dela Cruz CS, Egan M, Laguna T, Britto CJ. SPLUNC1: a novel marker of cystic fibrosis exacerbations. The European Respiratory Journal 2021, 58 PMID: 33958427, PMCID: PMC8571118, DOI: 10.1183/13993003.00507-2020.
- Dela Cruz CS, Evans SE, Restrepo MI, Dean N, Torres A, Amara-Elori I, Awasthi S, Caler E, Cao B, Chalmers JD, Chastre J, Cohen TS, Cohen AH, Crothers K, Di YP, Egan ME, Feldman C, Gautam S, Halstead ES, Herold S, Jones BE, Luna C, Niederman MS, Mendez R, Menendez R, Mizgerd JP, Nusrat R, Ramirez J, Shindo Y, Waterer G, Yeligar SM, Wunderink RG. Understanding the Host in the Management of Pneumonia. An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2021, 18: 1087-1097. PMID: 34242148, PMCID: PMC8328365, DOI: 10.1513/AnnalsATS.202102-209ST.
- Ullrich SJ, Freedman-Weiss M, Ahle S, Mandl HK, Piotrowski-Daspit AS, Roberts K, Yung N, Maassel N, Bauer-Pisani T, Ricciardi AS, Egan ME, Glazer PM, Saltzman WM, Stitelman DH. Nanoparticles for delivery of agents to fetal lungs. Acta Biomaterialia 2021, 123: 346-353. PMID: 33484911, PMCID: PMC7962939, DOI: 10.1016/j.actbio.2021.01.024.
- Egan ME. Emerging technologies for cystic fibrosis transmembrane conductance regulator restoration in all people with CF. Pediatric Pulmonology 2021, 56 Suppl 1: S32-S39. PMID: 32681713, PMCID: PMC8114183, DOI: 10.1002/ppul.24965.
- Schupp JC, Khanal S, Gomez JL, Sauler M, Adams TS, Chupp GL, Yan X, Poli S, Zhao Y, Montgomery RR, Rosas IO, Dela Cruz CS, Bruscia EM, Egan ME, Kaminski N, Britto CJ. Single-Cell Transcriptional Archetypes of Airway Inflammation in Cystic Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2020, 202: 1419-1429. PMID: 32603604, PMCID: PMC7667912, DOI: 10.1164/rccm.202004-0991OC.
- Egan ME. Cystic fibrosis transmembrane conductance receptor modulator therapy in cystic fibrosis, an update. Current Opinion In Pediatrics 2020, 32: 384-388. PMID: 32374578, DOI: 10.1097/MOP.0000000000000892.
- Quinn RA, Melnik AV, Vrbanac A, Fu T, Patras KA, Christy MP, Bodai Z, Belda-Ferre P, Tripathi A, Chung LK, Downes M, Welch RD, Quinn M, Humphrey G, Panitchpakdi M, Weldon KC, Aksenov A, da Silva R, Avila-Pacheco J, Clish C, Bae S, Mallick H, Franzosa EA, Lloyd-Price J, Bussell R, Thron T, Nelson AT, Wang M, Leszczynski E, Vargas F, Gauglitz JM, Meehan MJ, Gentry E, Arthur TD, Komor AC, Poulsen O, Boland BS, Chang JT, Sandborn WJ, Lim M, Garg N, Lumeng JC, Xavier RJ, Kazmierczak BI, Jain R, Egan M, Rhee KE, Ferguson D, Raffatellu M, Vlamakis H, Haddad GG, Siegel D, Huttenhower C, Mazmanian SK, Evans RM, Nizet V, Knight R, Dorrestein PC. Global chemical effects of the microbiome include new bile-acid conjugations. Nature 2020, 579: 123-129. PMID: 32103176, PMCID: PMC7252668, DOI: 10.1038/s41586-020-2047-9.
- Di Pietro C, Zhang PX, O'Rourke TK, Murray TS, Wang L, Britto CJ, Koff JL, Krause DS, Egan ME, Bruscia EM. Ezrin links CFTR to TLR4 signaling to orchestrate anti-bacterial immune response in macrophages. Scientific Reports 2017, 7: 10882. PMID: 28883468, PMCID: PMC5589856, DOI: 10.1038/s41598-017-11012-7.
- Egan ME. Effects of Lumacaftor/Ivacaftor in a Pediatric Cohort Homozygous for F508del-CFTR. American Journal Of Respiratory And Critical Care Medicine 2017, 195: 849-850. PMID: 28362199, DOI: 10.1164/rccm.201611-2290ED.
- Bruscia E, Zhang PX, Barone C, Scholte B, Homer RJ, Krause D, Egan ME. Increased susceptibility of Cftr-/- mice to LPS-induced lung remodeling. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2016, 310: L711-9. PMID: 26851259, PMCID: PMC4836110, DOI: 10.1152/ajplung.00284.2015.
- Egan ME. Genetics of Cystic Fibrosis: Clinical Implications. Clinics In Chest Medicine 2016, 37: 9-16. PMID: 26857764, DOI: 10.1016/j.ccm.2015.11.002.
- Vanstone MB, Egan ME, Zhang JH, Carpenter TO. Association between serum 25-hydroxyvitamin D level and pulmonary exacerbations in cystic fibrosis. Pediatric Pulmonology 2015, 50: 441-6. PMID: 25657016, DOI: 10.1002/ppul.23161.
- McNeer NA, Anandalingam K, Fields RJ, Caputo C, Kopic S, Gupta A, Quijano E, Polikoff L, Kong Y, Bahal R, Geibel JP, Glazer PM, Saltzman WM, Egan ME. Nanoparticles that deliver triplex-forming peptide nucleic acid molecules correct F508del CFTR in airway epithelium. Nature Communications 2015, 6: 6952. PMID: 25914116, PMCID: PMC4480796, DOI: 10.1038/ncomms7952.
- Fields RJ, Quijano E, McNeer NA, Caputo C, Bahal R, Anandalingam K, Egan ME, Glazer PM, Saltzman WM. Modified poly(lactic-co-glycolic acid) nanoparticles for enhanced cellular uptake and gene editing in the lung. Advanced Healthcare Materials 2015, 4: 361-6. PMID: 25156908, PMCID: PMC4339402, DOI: 10.1002/adhm.201400355.
- Zhang PX, Cheng J, Zou S, D'Souza AD, Koff JL, Lu J, Lee PJ, Krause DS, Egan ME, Bruscia EM. Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation. Nature Communications 2015, 6: 6221. PMID: 25665524, PMCID: PMC4324503, DOI: 10.1038/ncomms7221.
- Towle D, Callan DA, Farrel PA, Egan ME, Murray TS. Baby bottle steam sterilizers disinfect home nebulizers inoculated with bacterial respiratory pathogens. Journal Of Cystic Fibrosis : Official Journal Of The European Cystic Fibrosis Society 2013, 12: 512-6. PMID: 23267773, DOI: 10.1016/j.jcf.2012.11.013.
- Zhang PX, Murray TS, Villella VR, Ferrari E, Esposito S, D'Souza A, Raia V, Maiuri L, Krause DS, Egan ME, Bruscia EM. Reduced caveolin-1 promotes hyperinflammation due to abnormal heme oxygenase-1 localization in lipopolysaccharide-challenged macrophages with dysfunctional cystic fibrosis transmembrane conductance regulator. Journal Of Immunology (Baltimore, Md. : 1950) 2013, 190: 5196-206. PMID: 23606537, PMCID: PMC3711148, DOI: 10.4049/jimmunol.1201607.
- Fields RJ, Cheng CJ, Quijano E, Weller C, Kristofik N, Duong N, Hoimes C, Egan ME, Saltzman WM. Surface modified poly(β amino ester)-containing nanoparticles for plasmid DNA delivery. Journal Of Controlled Release : Official Journal Of The Controlled Release Society 2012, 164: 41-8. PMID: 23041278, PMCID: PMC3625648, DOI: 10.1016/j.jconrel.2012.09.020.
- Shenoy A, Kopic S, Murek M, Caputo C, Geibel JP, Egan ME. Calcium-modulated chloride pathways contribute to chloride flux in murine cystic fibrosis-affected macrophages. Pediatric Research 2011, 70: 447-52. PMID: 21796019, PMCID: PMC3189336, DOI: 10.1203/PDR.0b013e31822f2448.
- Bruscia EM, Zhang PX, Satoh A, Caputo C, Medzhitov R, Shenoy A, Egan ME, Krause DS. Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. Journal Of Immunology (Baltimore, Md. : 1950) 2011, 186: 6990-8. PMID: 21593379, PMCID: PMC3111054, DOI: 10.4049/jimmunol.1100396.
- Cartiera MS, Ferreira EC, Caputo C, Egan ME, Caplan MJ, Saltzman WM. Partial correction of cystic fibrosis defects with PLGA nanoparticles encapsulating curcumin. Molecular Pharmaceutics 2010, 7: 86-93. PMID: 19886674, PMCID: PMC2815009, DOI: 10.1021/mp900138a.
- Bruscia EM, Zhang PX, Ferreira E, Caputo C, Emerson JW, Tuck D, Krause DS, Egan ME. Macrophages directly contribute to the exaggerated inflammatory response in cystic fibrosis transmembrane conductance regulator-/- mice. American Journal Of Respiratory Cell And Molecular Biology 2009, 40: 295-304. PMID: 18776130, PMCID: PMC2645527, DOI: 10.1165/rcmb.2008-0170OC.
- Weiner SA, Caputo C, Bruscia E, Ferreira EC, Price JE, Krause DS, Egan ME. Rectal potential difference and the functional expression of CFTR in the gastrointestinal epithelia in cystic fibrosis mouse models. Pediatric Research 2008, 63: 73-8. PMID: 18043508, DOI: 10.1203/PDR.0b013e31815b4bc6.
- Sidani SM, Kirchhoff P, Socrates T, Stelter L, Ferreira E, Caputo C, Roberts KE, Bell RL, Egan ME, Geibel JP. DeltaF508 mutation results in impaired gastric acid secretion. The Journal Of Biological Chemistry 2007, 282: 6068-74. PMID: 17178714, DOI: 10.1074/jbc.M608427200.
- Murray TS, Egan M, Kazmierczak BI. Pseudomonas aeruginosa chronic colonization in cystic fibrosis patients. Current Opinion In Pediatrics 2007, 19: 83-8. PMID: 17224667, DOI: 10.1097/MOP.0b013e3280123a5d.
- Bruscia EM, Ziegler EC, Price JE, Weiner S, Egan ME, Krause DS. Engraftment of donor-derived epithelial cells in multiple organs following bone marrow transplantation into newborn mice. Stem Cells (Dayton, Ohio) 2006, 24: 2299-308. PMID: 16794262, DOI: 10.1634/stemcells.2006-0166.
- Bruscia EM, Price JE, Cheng EC, Weiner S, Caputo C, Ferreira EC, Egan ME, Krause DS. Assessment of cystic fibrosis transmembrane conductance regulator (CFTR) activity in CFTR-null mice after bone marrow transplantation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 2965-70. PMID: 16481627, PMCID: PMC1413802, DOI: 10.1073/pnas.0510758103.
- Egan ME, Pearson M, Weiner SA, Rajendran V, Rubin D, Glöckner-Pagel J, Canny S, Du K, Lukacs GL, Caplan MJ. Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. Science (New York, N.Y.) 2004, 304: 600-2. PMID: 15105504, DOI: 10.1126/science.1093941.
- Egan ME, Glöckner-Pagel J, Ambrose C, Cahill PA, Pappoe L, Balamuth N, Cho E, Canny S, Wagner CA, Geibel J, Caplan MJ. Calcium-pump inhibitors induce functional surface expression of Delta F508-CFTR protein in cystic fibrosis epithelial cells. Nature Medicine 2002, 8: 485-92. PMID: 11984593, DOI: 10.1038/nm0502-485.
Locations
Yale Pediatric Respiratory Medicine
Yale New Haven Children's Hospital
1 Park Street, Ste West Pavilion - 2nd Floor
New Haven, CT 06504
- Yale Pediatric Respiratory MedicineYale New Haven Children's Hospital1 Park Street, Ste West Pavilion - 2nd FloorNew Haven, CT 06504
Titles
- Professor of Pediatrics (Respiratory) and of Cellular And Molecular Physiology
- Director, Cystic Fibrosis Center
- Vice Chair for Research, Department of Pediatrics
Education & Training
- FellowThe Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins Hospital (1992)
- ResidentJohns Hopkins Hospital (1989)
- InternThe Johns Hopkins Hospital (1987)
- MDMount Sinai School of Medicine (1986)
Additional Information
Honors & Recognitions
- Hartwell Individual Biomedical Research Award: Hartwell Foundation (2011)
- Society of Pediatric Research, Membership Secretary: (2004)
- Society of Distinguished Teachers: Yale University School of Medicine (2002)
- The Leah Lowenstein Award, Faculty Teaching Award: Yale School of Medicine (2002)
Professional Service
- The Charles Hood Child Health Research Committee (2010 - Present): Reviewer
- (2008 - 2010): Brown-Coxe Review Committee
- (2008 - Present): Drug Monitoring Safety Board CF Foundation
- NIH (2008 - Present): Member
- (2007 - 2008): ATS Pediatric Assembly Nominating Committee Chairman
- Department of Pediatrics Faculty Development Committee
- MD/PhD Student Selection Committee
- Progress Committee, Yale University School of Medicine
- Cystic Fibrosis Foundation Research Review Committee
- FDA Orphan Disease Grant Review Program
Publications
- Di Pietro C, Öz HH, Zhang PX, Cheng EC, Martis V, Bonfield TL, Kelley TJ, Jubin R, Abuchowski A, Krause DS, Egan ME, Murray TS, Bruscia EM. Recruitment of monocytes primed to express heme oxygenase-1 ameliorates pathological lung inflammation in cystic fibrosis. Experimental & Molecular Medicine 2022, 54: 639-652. PMID: 35581352, PMCID: PMC9166813, DOI: 10.1038/s12276-022-00770-8.
- Luks VL, Mandl H, DiRito J, Barone C, Freedman-Weiss MR, Ricciardi AS, Tietjen GG, Egan ME, Saltzman WM, Stitelman DH. Surface conjugation of antibodies improves nanoparticle uptake in bronchial epithelial cells. PloS One 2022, 17: e0266218. PMID: 35385514, PMCID: PMC8986008, DOI: 10.1371/journal.pone.0266218.
- Khanal S, Webster M, Niu N, Zielonka J, Nunez M, Chupp G, Slade MD, Cohn L, Sauler M, Gomez JL, Tarran R, Sharma L, Dela Cruz CS, Egan M, Laguna T, Britto CJ. SPLUNC1: a novel marker of cystic fibrosis exacerbations. The European Respiratory Journal 2021, 58 PMID: 33958427, PMCID: PMC8571118, DOI: 10.1183/13993003.00507-2020.
- Dela Cruz CS, Evans SE, Restrepo MI, Dean N, Torres A, Amara-Elori I, Awasthi S, Caler E, Cao B, Chalmers JD, Chastre J, Cohen TS, Cohen AH, Crothers K, Di YP, Egan ME, Feldman C, Gautam S, Halstead ES, Herold S, Jones BE, Luna C, Niederman MS, Mendez R, Menendez R, Mizgerd JP, Nusrat R, Ramirez J, Shindo Y, Waterer G, Yeligar SM, Wunderink RG. Understanding the Host in the Management of Pneumonia. An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2021, 18: 1087-1097. PMID: 34242148, PMCID: PMC8328365, DOI: 10.1513/AnnalsATS.202102-209ST.
- Ullrich SJ, Freedman-Weiss M, Ahle S, Mandl HK, Piotrowski-Daspit AS, Roberts K, Yung N, Maassel N, Bauer-Pisani T, Ricciardi AS, Egan ME, Glazer PM, Saltzman WM, Stitelman DH. Nanoparticles for delivery of agents to fetal lungs. Acta Biomaterialia 2021, 123: 346-353. PMID: 33484911, PMCID: PMC7962939, DOI: 10.1016/j.actbio.2021.01.024.
- Egan ME. Emerging technologies for cystic fibrosis transmembrane conductance regulator restoration in all people with CF. Pediatric Pulmonology 2021, 56 Suppl 1: S32-S39. PMID: 32681713, PMCID: PMC8114183, DOI: 10.1002/ppul.24965.
- Schupp JC, Khanal S, Gomez JL, Sauler M, Adams TS, Chupp GL, Yan X, Poli S, Zhao Y, Montgomery RR, Rosas IO, Dela Cruz CS, Bruscia EM, Egan ME, Kaminski N, Britto CJ. Single-Cell Transcriptional Archetypes of Airway Inflammation in Cystic Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2020, 202: 1419-1429. PMID: 32603604, PMCID: PMC7667912, DOI: 10.1164/rccm.202004-0991OC.
- Egan ME. Cystic fibrosis transmembrane conductance receptor modulator therapy in cystic fibrosis, an update. Current Opinion In Pediatrics 2020, 32: 384-388. PMID: 32374578, DOI: 10.1097/MOP.0000000000000892.
- Quinn RA, Melnik AV, Vrbanac A, Fu T, Patras KA, Christy MP, Bodai Z, Belda-Ferre P, Tripathi A, Chung LK, Downes M, Welch RD, Quinn M, Humphrey G, Panitchpakdi M, Weldon KC, Aksenov A, da Silva R, Avila-Pacheco J, Clish C, Bae S, Mallick H, Franzosa EA, Lloyd-Price J, Bussell R, Thron T, Nelson AT, Wang M, Leszczynski E, Vargas F, Gauglitz JM, Meehan MJ, Gentry E, Arthur TD, Komor AC, Poulsen O, Boland BS, Chang JT, Sandborn WJ, Lim M, Garg N, Lumeng JC, Xavier RJ, Kazmierczak BI, Jain R, Egan M, Rhee KE, Ferguson D, Raffatellu M, Vlamakis H, Haddad GG, Siegel D, Huttenhower C, Mazmanian SK, Evans RM, Nizet V, Knight R, Dorrestein PC. Global chemical effects of the microbiome include new bile-acid conjugations. Nature 2020, 579: 123-129. PMID: 32103176, PMCID: PMC7252668, DOI: 10.1038/s41586-020-2047-9.
- Di Pietro C, Zhang PX, O'Rourke TK, Murray TS, Wang L, Britto CJ, Koff JL, Krause DS, Egan ME, Bruscia EM. Ezrin links CFTR to TLR4 signaling to orchestrate anti-bacterial immune response in macrophages. Scientific Reports 2017, 7: 10882. PMID: 28883468, PMCID: PMC5589856, DOI: 10.1038/s41598-017-11012-7.
- Egan ME. Effects of Lumacaftor/Ivacaftor in a Pediatric Cohort Homozygous for F508del-CFTR. American Journal Of Respiratory And Critical Care Medicine 2017, 195: 849-850. PMID: 28362199, DOI: 10.1164/rccm.201611-2290ED.
- Bruscia E, Zhang PX, Barone C, Scholte B, Homer RJ, Krause D, Egan ME. Increased susceptibility of Cftr-/- mice to LPS-induced lung remodeling. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2016, 310: L711-9. PMID: 26851259, PMCID: PMC4836110, DOI: 10.1152/ajplung.00284.2015.
- Egan ME. Genetics of Cystic Fibrosis: Clinical Implications. Clinics In Chest Medicine 2016, 37: 9-16. PMID: 26857764, DOI: 10.1016/j.ccm.2015.11.002.
- Vanstone MB, Egan ME, Zhang JH, Carpenter TO. Association between serum 25-hydroxyvitamin D level and pulmonary exacerbations in cystic fibrosis. Pediatric Pulmonology 2015, 50: 441-6. PMID: 25657016, DOI: 10.1002/ppul.23161.
- McNeer NA, Anandalingam K, Fields RJ, Caputo C, Kopic S, Gupta A, Quijano E, Polikoff L, Kong Y, Bahal R, Geibel JP, Glazer PM, Saltzman WM, Egan ME. Nanoparticles that deliver triplex-forming peptide nucleic acid molecules correct F508del CFTR in airway epithelium. Nature Communications 2015, 6: 6952. PMID: 25914116, PMCID: PMC4480796, DOI: 10.1038/ncomms7952.
- Fields RJ, Quijano E, McNeer NA, Caputo C, Bahal R, Anandalingam K, Egan ME, Glazer PM, Saltzman WM. Modified poly(lactic-co-glycolic acid) nanoparticles for enhanced cellular uptake and gene editing in the lung. Advanced Healthcare Materials 2015, 4: 361-6. PMID: 25156908, PMCID: PMC4339402, DOI: 10.1002/adhm.201400355.
- Zhang PX, Cheng J, Zou S, D'Souza AD, Koff JL, Lu J, Lee PJ, Krause DS, Egan ME, Bruscia EM. Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation. Nature Communications 2015, 6: 6221. PMID: 25665524, PMCID: PMC4324503, DOI: 10.1038/ncomms7221.
- Towle D, Callan DA, Farrel PA, Egan ME, Murray TS. Baby bottle steam sterilizers disinfect home nebulizers inoculated with bacterial respiratory pathogens. Journal Of Cystic Fibrosis : Official Journal Of The European Cystic Fibrosis Society 2013, 12: 512-6. PMID: 23267773, DOI: 10.1016/j.jcf.2012.11.013.
- Zhang PX, Murray TS, Villella VR, Ferrari E, Esposito S, D'Souza A, Raia V, Maiuri L, Krause DS, Egan ME, Bruscia EM. Reduced caveolin-1 promotes hyperinflammation due to abnormal heme oxygenase-1 localization in lipopolysaccharide-challenged macrophages with dysfunctional cystic fibrosis transmembrane conductance regulator. Journal Of Immunology (Baltimore, Md. : 1950) 2013, 190: 5196-206. PMID: 23606537, PMCID: PMC3711148, DOI: 10.4049/jimmunol.1201607.
- Fields RJ, Cheng CJ, Quijano E, Weller C, Kristofik N, Duong N, Hoimes C, Egan ME, Saltzman WM. Surface modified poly(β amino ester)-containing nanoparticles for plasmid DNA delivery. Journal Of Controlled Release : Official Journal Of The Controlled Release Society 2012, 164: 41-8. PMID: 23041278, PMCID: PMC3625648, DOI: 10.1016/j.jconrel.2012.09.020.
- Shenoy A, Kopic S, Murek M, Caputo C, Geibel JP, Egan ME. Calcium-modulated chloride pathways contribute to chloride flux in murine cystic fibrosis-affected macrophages. Pediatric Research 2011, 70: 447-52. PMID: 21796019, PMCID: PMC3189336, DOI: 10.1203/PDR.0b013e31822f2448.
- Bruscia EM, Zhang PX, Satoh A, Caputo C, Medzhitov R, Shenoy A, Egan ME, Krause DS. Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. Journal Of Immunology (Baltimore, Md. : 1950) 2011, 186: 6990-8. PMID: 21593379, PMCID: PMC3111054, DOI: 10.4049/jimmunol.1100396.
- Cartiera MS, Ferreira EC, Caputo C, Egan ME, Caplan MJ, Saltzman WM. Partial correction of cystic fibrosis defects with PLGA nanoparticles encapsulating curcumin. Molecular Pharmaceutics 2010, 7: 86-93. PMID: 19886674, PMCID: PMC2815009, DOI: 10.1021/mp900138a.
- Bruscia EM, Zhang PX, Ferreira E, Caputo C, Emerson JW, Tuck D, Krause DS, Egan ME. Macrophages directly contribute to the exaggerated inflammatory response in cystic fibrosis transmembrane conductance regulator-/- mice. American Journal Of Respiratory Cell And Molecular Biology 2009, 40: 295-304. PMID: 18776130, PMCID: PMC2645527, DOI: 10.1165/rcmb.2008-0170OC.
- Weiner SA, Caputo C, Bruscia E, Ferreira EC, Price JE, Krause DS, Egan ME. Rectal potential difference and the functional expression of CFTR in the gastrointestinal epithelia in cystic fibrosis mouse models. Pediatric Research 2008, 63: 73-8. PMID: 18043508, DOI: 10.1203/PDR.0b013e31815b4bc6.
- Sidani SM, Kirchhoff P, Socrates T, Stelter L, Ferreira E, Caputo C, Roberts KE, Bell RL, Egan ME, Geibel JP. DeltaF508 mutation results in impaired gastric acid secretion. The Journal Of Biological Chemistry 2007, 282: 6068-74. PMID: 17178714, DOI: 10.1074/jbc.M608427200.
- Murray TS, Egan M, Kazmierczak BI. Pseudomonas aeruginosa chronic colonization in cystic fibrosis patients. Current Opinion In Pediatrics 2007, 19: 83-8. PMID: 17224667, DOI: 10.1097/MOP.0b013e3280123a5d.
- Bruscia EM, Ziegler EC, Price JE, Weiner S, Egan ME, Krause DS. Engraftment of donor-derived epithelial cells in multiple organs following bone marrow transplantation into newborn mice. Stem Cells (Dayton, Ohio) 2006, 24: 2299-308. PMID: 16794262, DOI: 10.1634/stemcells.2006-0166.
- Bruscia EM, Price JE, Cheng EC, Weiner S, Caputo C, Ferreira EC, Egan ME, Krause DS. Assessment of cystic fibrosis transmembrane conductance regulator (CFTR) activity in CFTR-null mice after bone marrow transplantation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 2965-70. PMID: 16481627, PMCID: PMC1413802, DOI: 10.1073/pnas.0510758103.
- Egan ME, Pearson M, Weiner SA, Rajendran V, Rubin D, Glöckner-Pagel J, Canny S, Du K, Lukacs GL, Caplan MJ. Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. Science (New York, N.Y.) 2004, 304: 600-2. PMID: 15105504, DOI: 10.1126/science.1093941.
- Egan ME, Glöckner-Pagel J, Ambrose C, Cahill PA, Pappoe L, Balamuth N, Cho E, Canny S, Wagner CA, Geibel J, Caplan MJ. Calcium-pump inhibitors induce functional surface expression of Delta F508-CFTR protein in cystic fibrosis epithelial cells. Nature Medicine 2002, 8: 485-92. PMID: 11984593, DOI: 10.1038/nm0502-485.
Locations
Yale Pediatric Respiratory Medicine
Yale New Haven Children's Hospital
1 Park Street, Ste West Pavilion - 2nd Floor
New Haven, CT 06504
- Yale Pediatric Respiratory MedicineYale New Haven Children's Hospital1 Park Street, Ste West Pavilion - 2nd FloorNew Haven, CT 06504
Yale Pediatric Respiratory Medicine
Yale New Haven Children's Hospital
1 Park Street, Ste West Pavilion - 2nd Floor
New Haven, CT 06504
- Yale Pediatric Respiratory MedicineYale New Haven Children's Hospital1 Park Street, Ste West Pavilion - 2nd FloorNew Haven, CT 06504