Margaret Pisani, MD, MPH
Pulmonology & Sleep Medicine, Pulmonary Critical Care
Biography
Margaret Pisani, MD, MPH, is a pulmonologist and critical care specialist.
Dr. Pisani’s research focuses on improving care and outcomes for critically ill patients. She studies delirium and sleep in the intensive care unit. She has a special interest in geriatric pulmonary and critically ill patients. In addition, she is interested in how sex and gender impact lung diseases and critical illness.
In 2021, Dr. Pisani received the CHEST College Medalist Award from the American College of Chest Physicians, bringing her career full circle. A grant from CHEST was what kick-started her research career.
Dr. Pisani is a professor of medicine (pulmonary, critical care, and sleep medicine) at Yale School of Medicine.
Titles
- Professor of Internal Medicine (Pulmonary, Critical Care & Sleep Medicine)
Education & Training
- FellowYale University School of Medicine (2001)
- MPHYale School of Public Health (2001)
- Chief ResidentYale-New Haven Hospital (1998)
- ResidentYale-New Haven Hospital (1997)
- MDTemple University (1994)
- MSNew Jersey Institute of Technology (1987)
- BSIona College (1985)
Additional Information
Honors & Recognitions
- Chest 2021 College Medalist Award: American College of Chest Physicians (CHEST) (2021)
- Carabasi Lectureship: Baylor Scott-White (2019)
- Chest Distinguished Educator Award: CHEST American College of Chest Physicians (2017), (2018), (2019), (2020)
- BI Clinical Research Award in Women's Pulmonary Health: (2009)
- William B. Abrams Award in Geriatric Clinical Pharmacology: (2006)
- NIH Loan Repayment Program: (2003), (2004), (2005), (2006), (2007), (2008), (2009)
- CHEST Foundation Young Investigator Award: (2001)
- The Emanuel M. Weinberger Award for Achievement in Rheumatology: (1994)
- John Creswell Memorial Award for Outstanding Performance in Medicine: (1993)
Professional Service
- American Board of Internal Medicine Critical Care Exam Committee (2020 - Present): Chair
- American Board of Internal Medicine (2020 - Present): Chair
- American College of Chest Physicians (ACCP) (2020 - Present): Women's Advisory Council
- American College of Chest Physicians (ACCP) (2019 - Present): Woman's Health Network
- NIDUS (2019): Grant Reviewer
- Seminars in Respiratory Medicine (2019): Guest Editor
- Yale University Service (2019): Participant
- Yale University Service (2019 - Present): Admissions Committee
- American Board of Internal Medicine, Critical Care Medicine Certification Exam Standard Setting (2019 - Present): Member
- American College of Chest Physicians (ACCP) (2019 - Present): Scientific Program C ommittee
Publications
- Mart M, Boehm L, Kiehl A, Gong M, Malhotra A, Owens R, Khan B, Pisani M, Schmidt G, Hite R, Exline M, Carson S, Hough C, Rock P, Douglas I, Feinstein D, Hyzy R, Schweickert W, Bowton D, Masica A, Orun O, Raman R, Pun B, Strength C, Rolfsen M, Pandharipande P, Brummel N, Hughes C, Patel M, Stollings J, Ely E, Jackson J, Girard T. Long-term outcomes after treatment of delirium during critical illness with antipsychotics (MIND-USA): a randomised, placebo-controlled, phase 3 trial. The Lancet Respiratory Medicine 2024 PMID: 38701817, DOI: 10.1016/s2213-2600(24)00077-8.
- Kim D, Lee H, Pawar A, Lee S, Park C, Levin R, Metzger E, Bateman B, Ely E, Pandharipande P, Pisani M, Hohmann S, Marcantonio E, Inouye S. Trends in use of antipsychotics and psychoactive drugs in older patients after major surgery. Journal Of The American Geriatrics Society 2023, 71: 3755-3767. PMID: 37676699, PMCID: PMC10841351, DOI: 10.1111/jgs.18580.
- Kim D, Lee S, Park C, Levin R, Metzger E, Bateman B, Ely E, Pandharipande P, Pisani M, Jones R, Marcantonio E, Inouye S. Comparative Safety Analysis of Oral Antipsychotics for In-Hospital Adverse Clinical Events in Older Adults After Major Surgery : A Nationwide Cohort Study. Annals Of Internal Medicine 2023, 176: 1153-1162. PMID: 37665998, PMCID: PMC10625498, DOI: 10.7326/m22-3021.
- Israel R, Lemieux S, Chernova I, Pisani M. Life-Threatening Amlodipine Overdose in an Obese Male. CHEST Journal 2016, 150: 372a. DOI: 10.1016/j.chest.2016.08.385.
- Knauert MP, Pisani MA. Dexmedetomidine for hyperactive delirium: worth further study. Journal Of Thoracic Disease 2016, 8: e999-e1002. PMID: 27747045, PMCID: PMC5059358, DOI: 10.21037/jtd.2016.08.14.
- Kamdar BB, Knauert MP, Jones SF, Parsons EC, Parthasarathy S, Pisani MA. Perceptions and Practices Regarding Sleep in the Intensive Care Unit. A Survey of 1,223 Critical Care Providers. Annals Of The American Thoracic Society 2016, 13: 1370-7. PMID: 27104770, PMCID: PMC5021080, DOI: 10.1513/annalsats.201601-087oc.
- Harris DA, Pensa MA, Redlich CA, Pisani MA, Rosenthal MS. Community-based Participatory Research Is Needed to Address Pulmonary Health Disparities. Annals Of The American Thoracic Society 2016, 13: 1231-1238. PMID: 27249657, DOI: 10.1513/annalsats.201601-054ps.
- Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Factors Associated with Functional Recovery among Older Intensive Care Unit Survivors. American Journal Of Respiratory And Critical Care Medicine 2016, 194: 299-307. PMID: 26840348, PMCID: PMC4970594, DOI: 10.1164/rccm.201506-1256oc.
- Knauert M, Jeon S, Murphy TE, Yaggi HK, Pisani MA, Redeker NS. Comparing average levels and peak occurrence of overnight sound in the medical intensive care unit on A-weighted and C-weighted decibel scales. Journal Of Critical Care 2016, 36: 1-7. PMID: 27546739, PMCID: PMC5097003, DOI: 10.1016/j.jcrc.2016.06.005.
- Vasunilashorn SM, Marcantonio ER, Gou Y, Pisani MA, Travison TG, Schmitt EM, Jones RN, Inouye SK. Quantifying the Severity of a Delirium Episode Throughout Hospitalization: the Combined Importance of Intensity and Duration. Journal Of General Internal Medicine 2016, 31: 1164-1171. PMID: 27259291, PMCID: PMC5023588, DOI: 10.1007/s11606-016-3671-9.
- Farrokh S, Castle AC, Heavner M, Pisani MA. Continuation Rate of Atypical Antipsychotics After Discharge When Initiated in the Intensive Care Unit. Journal Of Pharmacy Practice 2016, 30: 342-346. PMID: 27129913, DOI: 10.1177/0897190016645026.
- Bramley K, Pisani MA, Murphy TE, Araujo KL, Homer RJ, Puchalski JT. Endobronchial Ultrasound-Guided Cautery-Assisted Transbronchial Forceps Biopsies: Safety and Sensitivity Relative to Transbronchial Needle Aspiration. The Annals Of Thoracic Surgery 2016, 101: 1870-1876. PMID: 26912301, PMCID: PMC4861078, DOI: 10.1016/j.athoracsur.2015.11.051.
- Han L, Pisani MA, Araujo KL, Allore HG. Use of Self-Matching to Control for Stable Patient Characteristics While Addressing Time-Varying Confounding on Treatment Effect: A Case Study of Older Intensive Care Patients. International Journal Of Statistics In Medical Research 2016, 5: 8-16. PMID: 27123153, PMCID: PMC4844076, DOI: 10.6000/1929-6029.2016.05.01.2.
- Murphy TE, Van Ness PH, Araujo KL, Pisani MA. An Empirical Method of Detecting Time-Dependent Confounding: An Observational Study of Next Day Delirium in a Medical ICU. International Journal Of Statistics In Medical Research 2016, 5: 41-47. PMID: 26798411, PMCID: PMC4718607, DOI: 10.6000/1929-6029.2016.05.01.4.
- Rowe T, Araujo KL, Van Ness PH, Pisani MA, Juthani-Mehta M. Outcomes of Older Adults With Sepsis at Admission to an Intensive Care Unit. Open Forum Infectious Diseases 2016, 3: ofw010. PMID: 26925430, PMCID: PMC4766385, DOI: 10.1093/ofid/ofw010.
- Ramaswamy A, Homer R, Killam J, Pisani MA, Murphy TE, Araujo K, Puchalski J. Comparison of Transbronchial and Cryobiopsies in Evaluation of Diffuse Parenchymal Lung Disease. Journal Of Bronchology & Interventional Pulmonology 2016, 23: 14-21. PMID: 26705007, PMCID: PMC4864578, DOI: 10.1097/lbr.0000000000000246.
- Murphy TE, Araujo KL, Pisani MA. The authors reply. Critical Care Medicine 2015, 43: e589-e590. PMID: 26575672, PMCID: PMC4686334, DOI: 10.1097/ccm.0000000000001342.
- Chauhan Z, Pisani M, Ahasic A. 479. Critical Care Medicine 2015, 43: 121. DOI: 10.1097/01.ccm.0000474307.00015.7d.
- Pisani M, Ferrante L. Intensive Care Unit Outcomes in Older Adults. 2015, 119-137. DOI: 10.1142/9789814635011_0005.
- DeBiasi EM, Akgün KM, Pisani M. Awake or Sedated: Trends in the Evaluation and Management of Agitation in the Intensive Care Unit. Seminars In Respiratory And Critical Care Medicine 2015, 36: 899-913. PMID: 26595050, DOI: 10.1055/s-0035-1564875.
- Pisani MA. The 3D-CAM provides a brief, easy to use, sensitive and specific delirium assessment tool for older hospitalised patients, both with and without dementia. Evidence-based Mental Health 2015, 18: 120. PMID: 26459467, DOI: 10.1136/eb-2014-102019.
- Attia EF, McGinnis KA, Feemster LC, Akgün KM, Butt AA, Graber CJ, Fine MJ, Goetz MB, Rodriguez-Barradas MC, Pisani MA, Tindle HA, Brown ST, Hoo G, Rimland D, Gibert CL, Huang L, Freiberg MS, Hough CL, Crothers K. Association of COPD With Risk for Pulmonary Infections Requiring Hospitalization in HIV-Infected Veterans. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2015, 70: 280-288. PMID: 26181820, PMCID: PMC4607625, DOI: 10.1097/qai.0000000000000751.
- Chima-Melton C, Murphy TE, Araujo KL, Pisani MA. The Impact of Race on Intensity of Care Provided to Older Adults in the Medical Intensive Care Unit. Journal Of Racial And Ethnic Health Disparities 2015, 3: 365-372. PMID: 27271078, PMCID: PMC4902115, DOI: 10.1007/s40615-015-0162-3.
- Oldham M, Pisani MA. Sedation in Critically Ill Patients. Critical Care Clinics 2015, 31: 563-587. PMID: 26118921, DOI: 10.1016/j.ccc.2015.03.010.
- Knauert MP, Haspel JA, Pisani MA. Sleep Loss and Circadian Rhythm Disruption in the Intensive Care Unit. Clinics In Chest Medicine 2015, 36: 419-429. PMID: 26304279, DOI: 10.1016/j.ccm.2015.05.008.
- Barakat LA, Juthani-Mehta M, Allore H, Trentalange M, Tate J, Rimland D, Pisani M, Akgün KM, Goetz MB, Butt AA, Rodriguez-Barradas M, Duggal M, Crothers K, Justice AC, Quagliarello VJ. Clinical outcomes of HIV‐infected men with CAP. HIV Medicine 2015, 16: 421-430. PMID: 25959543, PMCID: PMC5015437, DOI: 10.1111/hiv.12244.
- Pisani MA, Araujo KL, Murphy TE. Association of Cumulative Dose of Haloperidol With Next-Day Delirium in Older Medical ICU Patients*. Critical Care Medicine 2015, 43: 996-1002. PMID: 25746748, PMCID: PMC4400211, DOI: 10.1097/ccm.0000000000000863.
- DeBiasi EM, Pisani MA, Murphy TE, Araujo K, Kookoolis A, Argento AC, Puchalski J. Mortality among patients with pleural effusion undergoing thoracentesis. European Respiratory Journal 2015, 46: 495-502. PMID: 25837039, PMCID: PMC4857137, DOI: 10.1183/09031936.00217114.
- Pisani MA, Friese RS, Gehlbach BK, Schwab RJ, Weinhouse GL, Jones SF. Sleep in the Intensive Care Unit. American Journal Of Respiratory And Critical Care Medicine 2015, 191: 731-738. PMID: 25594808, PMCID: PMC5447310, DOI: 10.1164/rccm.201411-2099ci.
- Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Functional Trajectories Among Older Persons Before and After Critical Illness. JAMA Internal Medicine 2015, 175: 523-529. PMID: 25665067, PMCID: PMC4467795, DOI: 10.1001/jamainternmed.2014.7889.
- Hopper K, Fried TR, Pisani MA. Health care worker attitudes and identified barriers to patient sleep in the medical intensive care unit. Heart & Lung 2015, 44: 95-99. PMID: 25686516, PMCID: PMC5632814, DOI: 10.1016/j.hrtlng.2015.01.011.
- Pisani M. Sleep in the intensive care unit: An oft-neglected key to health restoration. Heart & Lung 2015, 44: 87. PMID: 25680805, DOI: 10.1016/j.hrtlng.2015.01.007.
- Argento AC, Murphy TE, Pisani MA, Araujo KL, Puchalski J. Patient-Centered Outcomes Following Thoracentesis. PLEURA 2015, 2: 237399751560040. PMID: 26767192, PMCID: PMC4708257, DOI: 10.1177/2373997515600404.
- Rowe T, Araujo K, Van Ness P, Pisani M, Juthani-Mehta M. 808Outcomes of Older Adults with Sepsis at Admission to an Intensive Care Unit. Open Forum Infectious Diseases 2014, 1: s230-s230. DOI: 10.1093/ofid/ofu052.516.
- Ahasic AM, Van Ness PH, Murphy TE, Araujo KL, Pisani MA. Functional status after critical illness: agreement between patient and proxy assessments. Age And Ageing 2014, 44: 506-510. PMID: 25324334, PMCID: PMC4411220, DOI: 10.1093/ageing/afu163.
- Perkins M, Pisani M, Puchalski J, Honiden S. A Rare Cause of Progressive Dysphagia and Dyspnea: Double Aortic Arch. CHEST Journal 2014, 146: 801a. DOI: 10.1378/chest.1991723.
- Knauert MP, Yaggi HK, Redeker NS, Murphy TE, Araujo KL, Pisani MA. Feasibility study of unattended polysomnography in medical intensive care unit patients. Heart & Lung 2014, 43: 445-452. PMID: 25023504, PMCID: PMC4150840, DOI: 10.1016/j.hrtlng.2014.06.049.
- Goyal G, Pisani MA, Murphy TE, Araujo KL, Puchalski JT. Advanced Diagnostic Bronchoscopy Using Conscious Sedation and the Laryngeal Nerve Block: Tolerability, Thoroughness, and Diagnostic Yield. Lung 2014, 192: 905-913. PMID: 24972639, PMCID: PMC5417331, DOI: 10.1007/s00408-014-9607-4.
- Hoang QN, Pisani MA, Inzucchi S, Hu B, Honiden S. The prevalence of undiagnosed diabetes mellitus and the association of baseline glycemic control on mortality in the intensive care unit: A prospective observational study. Journal Of Critical Care 2014, 29: 1052-1056. PMID: 25092614, DOI: 10.1016/j.jcrc.2014.06.007.
- Kookoolis AS, Puchalski JT, Murphy TE, Araujo KL, Pisani MA. Mortality of Hospitalized Patients with Pleural Effusions. Journal Of Pulmonary & Respiratory Medicine 2014, 4: 184. PMID: 25977841, PMCID: PMC4428160, DOI: 10.4172/2161-105x.1000184.
- Mannam P, Shinn AS, Srivastava A, Neamu RF, Walker WE, Bohanon M, Merkel J, Kang MJ, Dela Cruz CS, Ahasic AM, Pisani MA, Trentalange M, West AP, Shadel GS, Elias JA, Lee PJ. MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2014, 306: l604-l619. PMID: 24487387, PMCID: PMC3962628, DOI: 10.1152/ajplung.00272.2013.
- Ryu C, Bramley K, Boffa D, Pisani M, Puchalski J. Endobronchial Treatment of Pulsatile Hemoptysis Complicating Y-Stent Management of Tracheobronchomalacia. CHEST Journal 2013, 144: 46a-46b. DOI: 10.1378/chest.1698542.
- Murphy E, Pisani M, Murphy T, Araujo K, Kookoolis A, Argento A, Puchalski J. Pleural Effusions and 30-Day Mortality. CHEST Journal 2013, 144: 507a-507b. DOI: 10.1378/chest.1703023.
- Ahasic A, Murphy T, Araujo K, Pisani M. Functional Status After Critical Illness: Agreement Between Patient and Proxy Assessments. CHEST Journal 2013, 144: 393a-393b. DOI: 10.1378/chest.1693988.
- Bramley K, Pisani M, Puchalski J. Electrocautery Knife Incisions During EBUS-Guided Miniforceps Biopsies. CHEST Journal 2013, 144: 84a-84b. DOI: 10.1378/chest.1703769.
- Erb C, Johnson K, Pisani M, Puchalski J. A Novel Airway Stabilization Technique for Respiratory Failure Associated With Tracheobronchomegaly. CHEST Journal 2013, 144: 17a-17b. DOI: 10.1378/chest.1702872.
- Erb C, Pisani M, Puchalski J. The Utility of a Silicone Y-Stent in the Secondary Carina for a Life-Altering Bronchoesophageal Fistula. CHEST Journal 2013, 144: 36a-36b. DOI: 10.1378/chest.1704809.
- Pisani MA, Bramley K, Vest MT, Akgün KM, Araujo KL, Murphy TE. Patterns of Opiate, Benzodiazepine, and Antipsychotic Drug Dosing in Older Patients in a Medical Intensive Care Unit. American Journal Of Critical Care 2013, 22: e62-e69. PMID: 23996429, PMCID: PMC4309662, DOI: 10.4037/ajcc2013835.
- Puchalski JT, Argento AC, Murphy TE, Araujo KL, Pisani MA. The Safety of Thoracentesis in Patients with Uncorrected Bleeding Risk. Annals Of The American Thoracic Society 2013, 10: 336-341. PMID: 23952852, PMCID: PMC3960907, DOI: 10.1513/annalsats.201210-088oc.
- Akgün KM, Tate JP, Pisani M, Fried T, Butt AA, Gibert CL, Huang L, Rodriguez-Barradas MC, Rimland D, Justice AC, Crothers K. Medical ICU Admission Diagnoses and Outcomes in Human Immunodeficiency Virus–Infected and Virus–Uninfected Veterans in the Combination Antiretroviral Era*. Critical Care Medicine 2013, 41: 1458-1467. PMID: 23507717, PMCID: PMC4283206, DOI: 10.1097/ccm.0b013e31827caa46.
- Akgün KM, Gordon K, Pisani M, Fried T, McGinnis KA, Tate JP, Butt AA, Gibert CL, Huang L, Rodriguez-Barradas MC, Rimland D, Justice AC, Crothers K. Risk Factors for Hospitalization and Medical Intensive Care Unit (MICU) Admission Among HIV-Infected Veterans. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2013, 62: 52-59. PMID: 23111572, PMCID: PMC4182723, DOI: 10.1097/qai.0b013e318278f3fa.
- Puchalski JT, Argento AC, Murphy TE, Araujo KL, Oliva IB, Rubinowitz AN, Pisani MA. Etiologies of bilateral pleural effusions. Respiratory Medicine 2012, 107: 284-291. PMID: 23219348, PMCID: PMC5421548, DOI: 10.1016/j.rmed.2012.10.004.
- Mathews K, Jenq G, Siner J, Long E, Pisani M. 156. Critical Care Medicine 2012, 40: 1-328. DOI: 10.1097/01.ccm.0000424376.53968.a1.
- Pisani MA, Ferrante L. Among patients admitted to ICU, delirium is most common in those with neurological diagnoses, and is associated with adverse health outcomes. Evidence-Based Nursing 2012, 16: 81. PMID: 23171569, DOI: 10.1136/eb-2012-101054.
- Knauert M, Yaggi H, Redeker N, Murphy T, Araujo K, Pisani M. Sources of Overnight Patient Sleep Disruption in the Medical Intensive Care Unit. CHEST Journal 2012, 142: 547a-547b. DOI: 10.1378/chest.1383037.
- Argento A, Pisani M, Murphy T, Araujo K, Kookoolis A, Johnson K, Puchalski J. Impact of Thoracentesis on Dyspnea and Quality of Life. CHEST Journal 2012, 142: 488a-488b. DOI: 10.1378/chest.1389760.
- Erb C, Pisani M, Murphy T, Araujo K, Puchalski J. The Safety, Tolerability And Outcomes Of Performing Endobronchial Ultrasound (EBUS) In Obese Patients. 2012, a3000-a3000. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3000.
- Knauert-Brown M, Yaggi H, Redeker N, Murphy T, Araujo K, Donlon T, Pisani M. Feasibility Of Conducting 24-Hour Polysomnography Studies In The Medical Intensive Care Unit. 2012, a1617-a1617. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1617.
- Mathews K, Jenq G, Siner J, Long E, Pisani M. "Short-Stay" Patients In The Intensive Care Unit: Characterizing Patient Acuity, Throughput, And Critical Care Resource Utilization. 2012, a6731-a6731. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a6731.
- Jones SF, Pisani MA. ICU delirium. Current Opinion In Critical Care 2012, 18: 146-151. PMID: 22322260, DOI: 10.1097/mcc.0b013e32835132b9.
- Akgün KM, Crothers K, Pisani M. Epidemiology and Management of Common Pulmonary Diseases in Older Persons. The Journals Of Gerontology Series A 2012, 67A: 276-291. PMID: 22337938, PMCID: PMC3297767, DOI: 10.1093/gerona/glr251.
- Murphy TE, Van Ness PH, Araujo KL, Pisani MA. Bayesian Time-Series Analysis of a Repeated-Measures Poisson Outcome With Excess Zeroes. American Journal Of Epidemiology 2011, 174: 1230-1237. PMID: 22025357, PMCID: PMC3254157, DOI: 10.1093/aje/kwr252.
- Mathur A, Sauler M, Pisani M. Pulmonary Embolism in Older Patients. 2011, 133-153. DOI: 10.1007/978-1-60761-727-3_7.
- Validating Smoking Data From the Veteran’s Affairs Health Factors Dataset, an Electronic Data SourceMcGinnis KA, Brandt CA, Skanderson M, Justice AC, Shahrir S, Butt AA, Brown ST, Freiberg MS, Gibert CL, Goetz MB, Kim JW, Pisani MA, Rimland D, Rodriguez-Barradas MC, Sico JJ, Tindle HA, Crothers K. Validating Smoking Data From the Veteran’s Affairs Health Factors Dataset, an Electronic Data Source. Nicotine & Tobacco Research 2011, 13: 1233-1239. PMID: 21911825, PMCID: PMC3223583, DOI: 10.1093/ntr/ntr206.
- Van Ness PH, Murphy TE, Araujo KL, Pisani MA. Multivariate graphical methods provide an insightful way to formulate explanatory hypotheses from limited categorical data. Journal Of Clinical Epidemiology 2011, 65: 179-188. PMID: 21889310, PMCID: PMC3250573, DOI: 10.1016/j.jclinepi.2011.06.007.
- Akgün KM, Huang L, Morris A, Justice AC, Pisani M, Crothers K. Critical Illness in HIV-Infected Patients in the Era of Combination Antiretroviral Therapy. Annals Of The American Thoracic Society 2011, 8: 301-307. PMID: 21653532, PMCID: PMC3132789, DOI: 10.1513/pats.201009-060wr.
- Panico M, Pisani M, Jenq G, Araujo K, Honiden S. Outcomes Following A Rapid Response And The Impact On Transfer To The Intensive Care Unit. 2011, a4725-a4725. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4725.
- Argento A, Pisani M, Johnson K, Qin L, Puchalski J. Thoracenteses Are Safe In Patients With Bleeding Tendencies. 2011, a4630-a4630. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4630.
- Akgün KM, Pisani M, Crothers K. The Changing Epidemiology of HIV-Infected Patients in the Intensive Care Unit. Journal Of Intensive Care Medicine 2011, 26: 151-164. PMID: 21436170, DOI: 10.1177/0885066610387996.
- Vest MT, Murphy TE, Araujo K, Pisani MA. Disability in activities of daily living, depression, and quality of life among older medical ICU survivors: a prospective cohort study. Health And Quality Of Life Outcomes 2011, 9: 9. PMID: 21294911, PMCID: PMC3041645, DOI: 10.1186/1477-7525-9-9.
- Akgün KM, Murphy TE, Araujo KL, Van Ness PH, Pisani M. Does Gender Impact Intensity of Care Provided to Older Medical Intensive Care Unit Patients? Critical Care Research And Practice 2010, 2010: 404608. PMID: 20981259, PMCID: PMC2964007, DOI: 10.1155/2010/404608.
- Mathur A, Pisani M, Araujo K, Trow T. Risk Factors for MICU Admission in Patients With Pulmonary Hypertension. CHEST Journal 2010, 138: 296a. DOI: 10.1378/chest.10537.
- Vest M, Murphy T, Araujo K, Pisani M. Disability In Activities Of Daily Living And Quality Of Life Among Older Medical ICU Survivors. 2010, a5358-a5358. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5358.
- Bramley K, Vest M, Murphy T, Araujo K, Pisani M. Sedative, Narcotic And Delirium Drug Dosing By Nursing Shift In A Medical ICU. 2010, a4549-a4549. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4549.
- Pisani MA, Murphy TE, Araujo KL, Van Ness PH. Factors associated with persistent delirium after intensive care unit admission in an older medical patient population. Journal Of Critical Care 2010, 25: 540.e1-540.e7. PMID: 20413252, PMCID: PMC2939229, DOI: 10.1016/j.jcrc.2010.02.009.
- Pisani M, Murphy T, Araujo K, Van Ness P. Duration of ICU Delirium, Severity of the Underlying Disease, and Mortality. American Journal Of Respiratory And Critical Care Medicine 2010, 181: 420-421. DOI: 10.1164/ajrccm.181.4.420.
- Pisani MA, Kong SY, Kasl SV, Murphy TE, Araujo KL, Van Ness PH. Days of Delirium Are Associated with 1-Year Mortality in an Older Intensive Care Unit Population. American Journal Of Respiratory And Critical Care Medicine 2009, 180: 1092-1097. PMID: 19745202, PMCID: PMC2784414, DOI: 10.1164/rccm.200904-0537oc.
- Pisani MA, Murphy TE, Araujo KL, Slattum P, Van Ness PH, Inouye SK. Benzodiazepine and opioid use and the duration of intensive care unit delirium in an older population*. Critical Care Medicine 2009, 37: 177-183. PMID: 19050611, PMCID: PMC2700732, DOI: 10.1097/ccm.0b013e318192fcf9.
- Pisani MA. Analytic Reviews: Considerations in Caring for the Critically Ill Older Patient. Journal Of Intensive Care Medicine 2008, 24: 83-95. PMID: 19114416, DOI: 10.1177/0885066608329942.
- Pisani MA. Delirium assessment in the intensive care unit: patient population matters. Critical Care 2008, 12: 131. PMID: 18423059, PMCID: PMC2447584, DOI: 10.1186/cc6847.
- Pisani M. Preface. Clinics In Chest Medicine 2007, 28: ix. DOI: 10.1016/j.ccm.2007.08.009.
- Siner JM, Pisani MA. Mechanical Ventilation and Acute Respiratory Distress Syndrome in Older Patients. Clinics In Chest Medicine 2007, 28: 783-791. PMID: 17967294, DOI: 10.1016/j.ccm.2007.08.008.
- Cosgriff JA, Pisani M, Bradley EH, O’Leary J, Fried TR. The Association between Treatment Preferences and Trajectories of Care at the End-of-Life. Journal Of General Internal Medicine 2007, 22: 1566-1571. PMID: 17874168, PMCID: PMC2219807, DOI: 10.1007/s11606-007-0362-6.
- Pisani MA, Murphy TE, Van Ness PH, Araujo KL, Inouye SK. Characteristics Associated With Delirium in Older Patients in a Medical Intensive Care Unit. JAMA Internal Medicine 2007, 167: 1629-1634. PMID: 17698685, DOI: 10.1001/archinte.167.15.1629.
- Van Ness PH, Murphy TE, Araujo KL, Pisani MA, Allore HG. The use of missingness screens in clinical epidemiologic research has implications for regression modeling. Journal Of Clinical Epidemiology 2007, 60: 1239-1245. PMID: 17998078, PMCID: PMC2443713, DOI: 10.1016/j.jclinepi.2007.03.006.
- Pisani MA, Araujo K, Van Ness PH, Zhang Y, Ely E, Inouye SK. A research algorithm to improve detection of delirium in the intensive care unit. Critical Care 2006, 10: r121. PMID: 16919169, PMCID: PMC1750978, DOI: 10.1186/cc5027.
- Friedman LN, Nash ER, Bryant J, Henry S, Shi J, D'Amato J, Khaled GH, Russi MB, O'Connor PG, Edberg SC, Pisani MA, Cain HC, Tanoue L, Weissman DN. High Rate of Negative Results of Tuberculin and QuantiFERON Tests Among Individuals With a History of Positive Skin Test Results. Infection Control And Hospital Epidemiology 2006, 27: 436-441. PMID: 16671022, DOI: 10.1086/503690.
- Pisani M, Ely E. Chapter 6 Monitoring and Treatment of Pain, Anxiety, and Delirium in the ICU. 2006, 51-59. DOI: 10.1016/b978-0-323-02844-8.50011-1.
- D'Ambrosio C, Stachenfeld NS, Pisani M, Mohsenin V. Sleep, breathing, and menopause: The effect of fluctuating estrogen and progesterone on sleep and breathing in women. Gender Medicine 2005, 2: 238-245. PMID: 16464735, DOI: 10.1016/s1550-8579(05)80053-1.
- Pisani MA, Redlich CA, McNicoll L, Ely EW, Friedkin RJ, Inouye SK. Short-term outcomes in older intensive care unit patients with dementia*. Critical Care Medicine 2005, 33: 1371-1376. PMID: 15942358, DOI: 10.1097/01.ccm.0000165558.83676.48.
- McNicoll L, Pisani MA, Ely EW, Gifford D, Inouye SK. Detection of Delirium in the Intensive Care Unit: Comparison of Confusion Assessment Method for the Intensive Care Unit with Confusion Assessment Method Ratings. Journal Of The American Geriatrics Society 2005, 53: 495-500. PMID: 15743296, DOI: 10.1111/j.1532-5415.2005.53171.x.
- Pisani MA, Redlich C, McNicoll L, Ely EW, Inouye SK. Underrecognition of Preexisting Cognitive Impairment by Physicians in Older ICU Patients. CHEST Journal 2003, 124: 2267-2274. PMID: 14665510, DOI: 10.1378/chest.124.6.2267.
- Pisani MA, McNicoll L, Inouye SK. Cognitive impairment in the intensive care unit. Clinics In Chest Medicine 2003, 24: 727-737. PMID: 14710700, DOI: 10.1016/s0272-5231(03)00092-3.
- Pisani MA, Inouye SK, McNicoll L, Redlich CA. Screening for Preexisting Cognitive Impairment in Older Intensive Care Unit Patients: Use of Proxy Assessment. Journal Of The American Geriatrics Society 2003, 51: 689-693. PMID: 12752846, DOI: 10.1034/j.1600-0579.2003.00215.x.
- McNicoll L, Pisani MA, Zhang Y, Ely EW, Siegel MD, Inouye SK. Delirium in the Intensive Care Unit: Occurrence and Clinical Course in Older Patients. Journal Of The American Geriatrics Society 2003, 51: 591-598. PMID: 12752832, DOI: 10.1034/j.1600-0579.2003.00201.x.
- Moslehi F, Ligas JR, Pisani MA, Epstein MA. The unsteady form of the Bernoulli equation for estimating pressure drop in the airways. Respiration Physiology 1989, 76: 319-26. PMID: 2749031, DOI: 10.1016/0034-5687(89)90072-8.
Biography
Margaret Pisani, MD, MPH, is a pulmonologist and critical care specialist.
Dr. Pisani’s research focuses on improving care and outcomes for critically ill patients. She studies delirium and sleep in the intensive care unit. She has a special interest in geriatric pulmonary and critically ill patients. In addition, she is interested in how sex and gender impact lung diseases and critical illness.
In 2021, Dr. Pisani received the CHEST College Medalist Award from the American College of Chest Physicians, bringing her career full circle. A grant from CHEST was what kick-started her research career.
Dr. Pisani is a professor of medicine (pulmonary, critical care, and sleep medicine) at Yale School of Medicine.
Titles
- Professor of Internal Medicine (Pulmonary, Critical Care & Sleep Medicine)
Education & Training
- FellowYale University School of Medicine (2001)
- MPHYale School of Public Health (2001)
- Chief ResidentYale-New Haven Hospital (1998)
- ResidentYale-New Haven Hospital (1997)
- MDTemple University (1994)
- MSNew Jersey Institute of Technology (1987)
- BSIona College (1985)
Additional Information
Honors & Recognitions
- Chest 2021 College Medalist Award: American College of Chest Physicians (CHEST) (2021)
- Carabasi Lectureship: Baylor Scott-White (2019)
- Chest Distinguished Educator Award: CHEST American College of Chest Physicians (2017), (2018), (2019), (2020)
- BI Clinical Research Award in Women's Pulmonary Health: (2009)
- William B. Abrams Award in Geriatric Clinical Pharmacology: (2006)
- NIH Loan Repayment Program: (2003), (2004), (2005), (2006), (2007), (2008), (2009)
- CHEST Foundation Young Investigator Award: (2001)
- The Emanuel M. Weinberger Award for Achievement in Rheumatology: (1994)
- John Creswell Memorial Award for Outstanding Performance in Medicine: (1993)
Professional Service
- American Board of Internal Medicine Critical Care Exam Committee (2020 - Present): Chair
- American Board of Internal Medicine (2020 - Present): Chair
- American College of Chest Physicians (ACCP) (2020 - Present): Women's Advisory Council
- American College of Chest Physicians (ACCP) (2019 - Present): Woman's Health Network
- NIDUS (2019): Grant Reviewer
- Seminars in Respiratory Medicine (2019): Guest Editor
- Yale University Service (2019): Participant
- Yale University Service (2019 - Present): Admissions Committee
- American Board of Internal Medicine, Critical Care Medicine Certification Exam Standard Setting (2019 - Present): Member
- American College of Chest Physicians (ACCP) (2019 - Present): Scientific Program C ommittee
Publications
- Mart M, Boehm L, Kiehl A, Gong M, Malhotra A, Owens R, Khan B, Pisani M, Schmidt G, Hite R, Exline M, Carson S, Hough C, Rock P, Douglas I, Feinstein D, Hyzy R, Schweickert W, Bowton D, Masica A, Orun O, Raman R, Pun B, Strength C, Rolfsen M, Pandharipande P, Brummel N, Hughes C, Patel M, Stollings J, Ely E, Jackson J, Girard T. Long-term outcomes after treatment of delirium during critical illness with antipsychotics (MIND-USA): a randomised, placebo-controlled, phase 3 trial. The Lancet Respiratory Medicine 2024 PMID: 38701817, DOI: 10.1016/s2213-2600(24)00077-8.
- Kim D, Lee H, Pawar A, Lee S, Park C, Levin R, Metzger E, Bateman B, Ely E, Pandharipande P, Pisani M, Hohmann S, Marcantonio E, Inouye S. Trends in use of antipsychotics and psychoactive drugs in older patients after major surgery. Journal Of The American Geriatrics Society 2023, 71: 3755-3767. PMID: 37676699, PMCID: PMC10841351, DOI: 10.1111/jgs.18580.
- Kim D, Lee S, Park C, Levin R, Metzger E, Bateman B, Ely E, Pandharipande P, Pisani M, Jones R, Marcantonio E, Inouye S. Comparative Safety Analysis of Oral Antipsychotics for In-Hospital Adverse Clinical Events in Older Adults After Major Surgery : A Nationwide Cohort Study. Annals Of Internal Medicine 2023, 176: 1153-1162. PMID: 37665998, PMCID: PMC10625498, DOI: 10.7326/m22-3021.
- Israel R, Lemieux S, Chernova I, Pisani M. Life-Threatening Amlodipine Overdose in an Obese Male. CHEST Journal 2016, 150: 372a. DOI: 10.1016/j.chest.2016.08.385.
- Knauert MP, Pisani MA. Dexmedetomidine for hyperactive delirium: worth further study. Journal Of Thoracic Disease 2016, 8: e999-e1002. PMID: 27747045, PMCID: PMC5059358, DOI: 10.21037/jtd.2016.08.14.
- Kamdar BB, Knauert MP, Jones SF, Parsons EC, Parthasarathy S, Pisani MA. Perceptions and Practices Regarding Sleep in the Intensive Care Unit. A Survey of 1,223 Critical Care Providers. Annals Of The American Thoracic Society 2016, 13: 1370-7. PMID: 27104770, PMCID: PMC5021080, DOI: 10.1513/annalsats.201601-087oc.
- Harris DA, Pensa MA, Redlich CA, Pisani MA, Rosenthal MS. Community-based Participatory Research Is Needed to Address Pulmonary Health Disparities. Annals Of The American Thoracic Society 2016, 13: 1231-1238. PMID: 27249657, DOI: 10.1513/annalsats.201601-054ps.
- Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Factors Associated with Functional Recovery among Older Intensive Care Unit Survivors. American Journal Of Respiratory And Critical Care Medicine 2016, 194: 299-307. PMID: 26840348, PMCID: PMC4970594, DOI: 10.1164/rccm.201506-1256oc.
- Knauert M, Jeon S, Murphy TE, Yaggi HK, Pisani MA, Redeker NS. Comparing average levels and peak occurrence of overnight sound in the medical intensive care unit on A-weighted and C-weighted decibel scales. Journal Of Critical Care 2016, 36: 1-7. PMID: 27546739, PMCID: PMC5097003, DOI: 10.1016/j.jcrc.2016.06.005.
- Vasunilashorn SM, Marcantonio ER, Gou Y, Pisani MA, Travison TG, Schmitt EM, Jones RN, Inouye SK. Quantifying the Severity of a Delirium Episode Throughout Hospitalization: the Combined Importance of Intensity and Duration. Journal Of General Internal Medicine 2016, 31: 1164-1171. PMID: 27259291, PMCID: PMC5023588, DOI: 10.1007/s11606-016-3671-9.
- Farrokh S, Castle AC, Heavner M, Pisani MA. Continuation Rate of Atypical Antipsychotics After Discharge When Initiated in the Intensive Care Unit. Journal Of Pharmacy Practice 2016, 30: 342-346. PMID: 27129913, DOI: 10.1177/0897190016645026.
- Bramley K, Pisani MA, Murphy TE, Araujo KL, Homer RJ, Puchalski JT. Endobronchial Ultrasound-Guided Cautery-Assisted Transbronchial Forceps Biopsies: Safety and Sensitivity Relative to Transbronchial Needle Aspiration. The Annals Of Thoracic Surgery 2016, 101: 1870-1876. PMID: 26912301, PMCID: PMC4861078, DOI: 10.1016/j.athoracsur.2015.11.051.
- Han L, Pisani MA, Araujo KL, Allore HG. Use of Self-Matching to Control for Stable Patient Characteristics While Addressing Time-Varying Confounding on Treatment Effect: A Case Study of Older Intensive Care Patients. International Journal Of Statistics In Medical Research 2016, 5: 8-16. PMID: 27123153, PMCID: PMC4844076, DOI: 10.6000/1929-6029.2016.05.01.2.
- Murphy TE, Van Ness PH, Araujo KL, Pisani MA. An Empirical Method of Detecting Time-Dependent Confounding: An Observational Study of Next Day Delirium in a Medical ICU. International Journal Of Statistics In Medical Research 2016, 5: 41-47. PMID: 26798411, PMCID: PMC4718607, DOI: 10.6000/1929-6029.2016.05.01.4.
- Rowe T, Araujo KL, Van Ness PH, Pisani MA, Juthani-Mehta M. Outcomes of Older Adults With Sepsis at Admission to an Intensive Care Unit. Open Forum Infectious Diseases 2016, 3: ofw010. PMID: 26925430, PMCID: PMC4766385, DOI: 10.1093/ofid/ofw010.
- Ramaswamy A, Homer R, Killam J, Pisani MA, Murphy TE, Araujo K, Puchalski J. Comparison of Transbronchial and Cryobiopsies in Evaluation of Diffuse Parenchymal Lung Disease. Journal Of Bronchology & Interventional Pulmonology 2016, 23: 14-21. PMID: 26705007, PMCID: PMC4864578, DOI: 10.1097/lbr.0000000000000246.
- Murphy TE, Araujo KL, Pisani MA. The authors reply. Critical Care Medicine 2015, 43: e589-e590. PMID: 26575672, PMCID: PMC4686334, DOI: 10.1097/ccm.0000000000001342.
- Chauhan Z, Pisani M, Ahasic A. 479. Critical Care Medicine 2015, 43: 121. DOI: 10.1097/01.ccm.0000474307.00015.7d.
- Pisani M, Ferrante L. Intensive Care Unit Outcomes in Older Adults. 2015, 119-137. DOI: 10.1142/9789814635011_0005.
- DeBiasi EM, Akgün KM, Pisani M. Awake or Sedated: Trends in the Evaluation and Management of Agitation in the Intensive Care Unit. Seminars In Respiratory And Critical Care Medicine 2015, 36: 899-913. PMID: 26595050, DOI: 10.1055/s-0035-1564875.
- Pisani MA. The 3D-CAM provides a brief, easy to use, sensitive and specific delirium assessment tool for older hospitalised patients, both with and without dementia. Evidence-based Mental Health 2015, 18: 120. PMID: 26459467, DOI: 10.1136/eb-2014-102019.
- Attia EF, McGinnis KA, Feemster LC, Akgün KM, Butt AA, Graber CJ, Fine MJ, Goetz MB, Rodriguez-Barradas MC, Pisani MA, Tindle HA, Brown ST, Hoo G, Rimland D, Gibert CL, Huang L, Freiberg MS, Hough CL, Crothers K. Association of COPD With Risk for Pulmonary Infections Requiring Hospitalization in HIV-Infected Veterans. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2015, 70: 280-288. PMID: 26181820, PMCID: PMC4607625, DOI: 10.1097/qai.0000000000000751.
- Chima-Melton C, Murphy TE, Araujo KL, Pisani MA. The Impact of Race on Intensity of Care Provided to Older Adults in the Medical Intensive Care Unit. Journal Of Racial And Ethnic Health Disparities 2015, 3: 365-372. PMID: 27271078, PMCID: PMC4902115, DOI: 10.1007/s40615-015-0162-3.
- Oldham M, Pisani MA. Sedation in Critically Ill Patients. Critical Care Clinics 2015, 31: 563-587. PMID: 26118921, DOI: 10.1016/j.ccc.2015.03.010.
- Knauert MP, Haspel JA, Pisani MA. Sleep Loss and Circadian Rhythm Disruption in the Intensive Care Unit. Clinics In Chest Medicine 2015, 36: 419-429. PMID: 26304279, DOI: 10.1016/j.ccm.2015.05.008.
- Barakat LA, Juthani-Mehta M, Allore H, Trentalange M, Tate J, Rimland D, Pisani M, Akgün KM, Goetz MB, Butt AA, Rodriguez-Barradas M, Duggal M, Crothers K, Justice AC, Quagliarello VJ. Clinical outcomes of HIV‐infected men with CAP. HIV Medicine 2015, 16: 421-430. PMID: 25959543, PMCID: PMC5015437, DOI: 10.1111/hiv.12244.
- Pisani MA, Araujo KL, Murphy TE. Association of Cumulative Dose of Haloperidol With Next-Day Delirium in Older Medical ICU Patients*. Critical Care Medicine 2015, 43: 996-1002. PMID: 25746748, PMCID: PMC4400211, DOI: 10.1097/ccm.0000000000000863.
- DeBiasi EM, Pisani MA, Murphy TE, Araujo K, Kookoolis A, Argento AC, Puchalski J. Mortality among patients with pleural effusion undergoing thoracentesis. European Respiratory Journal 2015, 46: 495-502. PMID: 25837039, PMCID: PMC4857137, DOI: 10.1183/09031936.00217114.
- Pisani MA, Friese RS, Gehlbach BK, Schwab RJ, Weinhouse GL, Jones SF. Sleep in the Intensive Care Unit. American Journal Of Respiratory And Critical Care Medicine 2015, 191: 731-738. PMID: 25594808, PMCID: PMC5447310, DOI: 10.1164/rccm.201411-2099ci.
- Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Functional Trajectories Among Older Persons Before and After Critical Illness. JAMA Internal Medicine 2015, 175: 523-529. PMID: 25665067, PMCID: PMC4467795, DOI: 10.1001/jamainternmed.2014.7889.
- Hopper K, Fried TR, Pisani MA. Health care worker attitudes and identified barriers to patient sleep in the medical intensive care unit. Heart & Lung 2015, 44: 95-99. PMID: 25686516, PMCID: PMC5632814, DOI: 10.1016/j.hrtlng.2015.01.011.
- Pisani M. Sleep in the intensive care unit: An oft-neglected key to health restoration. Heart & Lung 2015, 44: 87. PMID: 25680805, DOI: 10.1016/j.hrtlng.2015.01.007.
- Argento AC, Murphy TE, Pisani MA, Araujo KL, Puchalski J. Patient-Centered Outcomes Following Thoracentesis. PLEURA 2015, 2: 237399751560040. PMID: 26767192, PMCID: PMC4708257, DOI: 10.1177/2373997515600404.
- Rowe T, Araujo K, Van Ness P, Pisani M, Juthani-Mehta M. 808Outcomes of Older Adults with Sepsis at Admission to an Intensive Care Unit. Open Forum Infectious Diseases 2014, 1: s230-s230. DOI: 10.1093/ofid/ofu052.516.
- Ahasic AM, Van Ness PH, Murphy TE, Araujo KL, Pisani MA. Functional status after critical illness: agreement between patient and proxy assessments. Age And Ageing 2014, 44: 506-510. PMID: 25324334, PMCID: PMC4411220, DOI: 10.1093/ageing/afu163.
- Perkins M, Pisani M, Puchalski J, Honiden S. A Rare Cause of Progressive Dysphagia and Dyspnea: Double Aortic Arch. CHEST Journal 2014, 146: 801a. DOI: 10.1378/chest.1991723.
- Knauert MP, Yaggi HK, Redeker NS, Murphy TE, Araujo KL, Pisani MA. Feasibility study of unattended polysomnography in medical intensive care unit patients. Heart & Lung 2014, 43: 445-452. PMID: 25023504, PMCID: PMC4150840, DOI: 10.1016/j.hrtlng.2014.06.049.
- Goyal G, Pisani MA, Murphy TE, Araujo KL, Puchalski JT. Advanced Diagnostic Bronchoscopy Using Conscious Sedation and the Laryngeal Nerve Block: Tolerability, Thoroughness, and Diagnostic Yield. Lung 2014, 192: 905-913. PMID: 24972639, PMCID: PMC5417331, DOI: 10.1007/s00408-014-9607-4.
- Hoang QN, Pisani MA, Inzucchi S, Hu B, Honiden S. The prevalence of undiagnosed diabetes mellitus and the association of baseline glycemic control on mortality in the intensive care unit: A prospective observational study. Journal Of Critical Care 2014, 29: 1052-1056. PMID: 25092614, DOI: 10.1016/j.jcrc.2014.06.007.
- Kookoolis AS, Puchalski JT, Murphy TE, Araujo KL, Pisani MA. Mortality of Hospitalized Patients with Pleural Effusions. Journal Of Pulmonary & Respiratory Medicine 2014, 4: 184. PMID: 25977841, PMCID: PMC4428160, DOI: 10.4172/2161-105x.1000184.
- Mannam P, Shinn AS, Srivastava A, Neamu RF, Walker WE, Bohanon M, Merkel J, Kang MJ, Dela Cruz CS, Ahasic AM, Pisani MA, Trentalange M, West AP, Shadel GS, Elias JA, Lee PJ. MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2014, 306: l604-l619. PMID: 24487387, PMCID: PMC3962628, DOI: 10.1152/ajplung.00272.2013.
- Ryu C, Bramley K, Boffa D, Pisani M, Puchalski J. Endobronchial Treatment of Pulsatile Hemoptysis Complicating Y-Stent Management of Tracheobronchomalacia. CHEST Journal 2013, 144: 46a-46b. DOI: 10.1378/chest.1698542.
- Murphy E, Pisani M, Murphy T, Araujo K, Kookoolis A, Argento A, Puchalski J. Pleural Effusions and 30-Day Mortality. CHEST Journal 2013, 144: 507a-507b. DOI: 10.1378/chest.1703023.
- Ahasic A, Murphy T, Araujo K, Pisani M. Functional Status After Critical Illness: Agreement Between Patient and Proxy Assessments. CHEST Journal 2013, 144: 393a-393b. DOI: 10.1378/chest.1693988.
- Bramley K, Pisani M, Puchalski J. Electrocautery Knife Incisions During EBUS-Guided Miniforceps Biopsies. CHEST Journal 2013, 144: 84a-84b. DOI: 10.1378/chest.1703769.
- Erb C, Johnson K, Pisani M, Puchalski J. A Novel Airway Stabilization Technique for Respiratory Failure Associated With Tracheobronchomegaly. CHEST Journal 2013, 144: 17a-17b. DOI: 10.1378/chest.1702872.
- Erb C, Pisani M, Puchalski J. The Utility of a Silicone Y-Stent in the Secondary Carina for a Life-Altering Bronchoesophageal Fistula. CHEST Journal 2013, 144: 36a-36b. DOI: 10.1378/chest.1704809.
- Pisani MA, Bramley K, Vest MT, Akgün KM, Araujo KL, Murphy TE. Patterns of Opiate, Benzodiazepine, and Antipsychotic Drug Dosing in Older Patients in a Medical Intensive Care Unit. American Journal Of Critical Care 2013, 22: e62-e69. PMID: 23996429, PMCID: PMC4309662, DOI: 10.4037/ajcc2013835.
- Puchalski JT, Argento AC, Murphy TE, Araujo KL, Pisani MA. The Safety of Thoracentesis in Patients with Uncorrected Bleeding Risk. Annals Of The American Thoracic Society 2013, 10: 336-341. PMID: 23952852, PMCID: PMC3960907, DOI: 10.1513/annalsats.201210-088oc.
- Akgün KM, Tate JP, Pisani M, Fried T, Butt AA, Gibert CL, Huang L, Rodriguez-Barradas MC, Rimland D, Justice AC, Crothers K. Medical ICU Admission Diagnoses and Outcomes in Human Immunodeficiency Virus–Infected and Virus–Uninfected Veterans in the Combination Antiretroviral Era*. Critical Care Medicine 2013, 41: 1458-1467. PMID: 23507717, PMCID: PMC4283206, DOI: 10.1097/ccm.0b013e31827caa46.
- Akgün KM, Gordon K, Pisani M, Fried T, McGinnis KA, Tate JP, Butt AA, Gibert CL, Huang L, Rodriguez-Barradas MC, Rimland D, Justice AC, Crothers K. Risk Factors for Hospitalization and Medical Intensive Care Unit (MICU) Admission Among HIV-Infected Veterans. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2013, 62: 52-59. PMID: 23111572, PMCID: PMC4182723, DOI: 10.1097/qai.0b013e318278f3fa.
- Puchalski JT, Argento AC, Murphy TE, Araujo KL, Oliva IB, Rubinowitz AN, Pisani MA. Etiologies of bilateral pleural effusions. Respiratory Medicine 2012, 107: 284-291. PMID: 23219348, PMCID: PMC5421548, DOI: 10.1016/j.rmed.2012.10.004.
- Mathews K, Jenq G, Siner J, Long E, Pisani M. 156. Critical Care Medicine 2012, 40: 1-328. DOI: 10.1097/01.ccm.0000424376.53968.a1.
- Pisani MA, Ferrante L. Among patients admitted to ICU, delirium is most common in those with neurological diagnoses, and is associated with adverse health outcomes. Evidence-Based Nursing 2012, 16: 81. PMID: 23171569, DOI: 10.1136/eb-2012-101054.
- Knauert M, Yaggi H, Redeker N, Murphy T, Araujo K, Pisani M. Sources of Overnight Patient Sleep Disruption in the Medical Intensive Care Unit. CHEST Journal 2012, 142: 547a-547b. DOI: 10.1378/chest.1383037.
- Argento A, Pisani M, Murphy T, Araujo K, Kookoolis A, Johnson K, Puchalski J. Impact of Thoracentesis on Dyspnea and Quality of Life. CHEST Journal 2012, 142: 488a-488b. DOI: 10.1378/chest.1389760.
- Erb C, Pisani M, Murphy T, Araujo K, Puchalski J. The Safety, Tolerability And Outcomes Of Performing Endobronchial Ultrasound (EBUS) In Obese Patients. 2012, a3000-a3000. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3000.
- Knauert-Brown M, Yaggi H, Redeker N, Murphy T, Araujo K, Donlon T, Pisani M. Feasibility Of Conducting 24-Hour Polysomnography Studies In The Medical Intensive Care Unit. 2012, a1617-a1617. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1617.
- Mathews K, Jenq G, Siner J, Long E, Pisani M. "Short-Stay" Patients In The Intensive Care Unit: Characterizing Patient Acuity, Throughput, And Critical Care Resource Utilization. 2012, a6731-a6731. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a6731.
- Jones SF, Pisani MA. ICU delirium. Current Opinion In Critical Care 2012, 18: 146-151. PMID: 22322260, DOI: 10.1097/mcc.0b013e32835132b9.
- Akgün KM, Crothers K, Pisani M. Epidemiology and Management of Common Pulmonary Diseases in Older Persons. The Journals Of Gerontology Series A 2012, 67A: 276-291. PMID: 22337938, PMCID: PMC3297767, DOI: 10.1093/gerona/glr251.
- Murphy TE, Van Ness PH, Araujo KL, Pisani MA. Bayesian Time-Series Analysis of a Repeated-Measures Poisson Outcome With Excess Zeroes. American Journal Of Epidemiology 2011, 174: 1230-1237. PMID: 22025357, PMCID: PMC3254157, DOI: 10.1093/aje/kwr252.
- Mathur A, Sauler M, Pisani M. Pulmonary Embolism in Older Patients. 2011, 133-153. DOI: 10.1007/978-1-60761-727-3_7.
- Validating Smoking Data From the Veteran’s Affairs Health Factors Dataset, an Electronic Data SourceMcGinnis KA, Brandt CA, Skanderson M, Justice AC, Shahrir S, Butt AA, Brown ST, Freiberg MS, Gibert CL, Goetz MB, Kim JW, Pisani MA, Rimland D, Rodriguez-Barradas MC, Sico JJ, Tindle HA, Crothers K. Validating Smoking Data From the Veteran’s Affairs Health Factors Dataset, an Electronic Data Source. Nicotine & Tobacco Research 2011, 13: 1233-1239. PMID: 21911825, PMCID: PMC3223583, DOI: 10.1093/ntr/ntr206.
- Van Ness PH, Murphy TE, Araujo KL, Pisani MA. Multivariate graphical methods provide an insightful way to formulate explanatory hypotheses from limited categorical data. Journal Of Clinical Epidemiology 2011, 65: 179-188. PMID: 21889310, PMCID: PMC3250573, DOI: 10.1016/j.jclinepi.2011.06.007.
- Akgün KM, Huang L, Morris A, Justice AC, Pisani M, Crothers K. Critical Illness in HIV-Infected Patients in the Era of Combination Antiretroviral Therapy. Annals Of The American Thoracic Society 2011, 8: 301-307. PMID: 21653532, PMCID: PMC3132789, DOI: 10.1513/pats.201009-060wr.
- Panico M, Pisani M, Jenq G, Araujo K, Honiden S. Outcomes Following A Rapid Response And The Impact On Transfer To The Intensive Care Unit. 2011, a4725-a4725. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4725.
- Argento A, Pisani M, Johnson K, Qin L, Puchalski J. Thoracenteses Are Safe In Patients With Bleeding Tendencies. 2011, a4630-a4630. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4630.
- Akgün KM, Pisani M, Crothers K. The Changing Epidemiology of HIV-Infected Patients in the Intensive Care Unit. Journal Of Intensive Care Medicine 2011, 26: 151-164. PMID: 21436170, DOI: 10.1177/0885066610387996.
- Vest MT, Murphy TE, Araujo K, Pisani MA. Disability in activities of daily living, depression, and quality of life among older medical ICU survivors: a prospective cohort study. Health And Quality Of Life Outcomes 2011, 9: 9. PMID: 21294911, PMCID: PMC3041645, DOI: 10.1186/1477-7525-9-9.
- Akgün KM, Murphy TE, Araujo KL, Van Ness PH, Pisani M. Does Gender Impact Intensity of Care Provided to Older Medical Intensive Care Unit Patients? Critical Care Research And Practice 2010, 2010: 404608. PMID: 20981259, PMCID: PMC2964007, DOI: 10.1155/2010/404608.
- Mathur A, Pisani M, Araujo K, Trow T. Risk Factors for MICU Admission in Patients With Pulmonary Hypertension. CHEST Journal 2010, 138: 296a. DOI: 10.1378/chest.10537.
- Vest M, Murphy T, Araujo K, Pisani M. Disability In Activities Of Daily Living And Quality Of Life Among Older Medical ICU Survivors. 2010, a5358-a5358. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5358.
- Bramley K, Vest M, Murphy T, Araujo K, Pisani M. Sedative, Narcotic And Delirium Drug Dosing By Nursing Shift In A Medical ICU. 2010, a4549-a4549. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4549.
- Pisani MA, Murphy TE, Araujo KL, Van Ness PH. Factors associated with persistent delirium after intensive care unit admission in an older medical patient population. Journal Of Critical Care 2010, 25: 540.e1-540.e7. PMID: 20413252, PMCID: PMC2939229, DOI: 10.1016/j.jcrc.2010.02.009.
- Pisani M, Murphy T, Araujo K, Van Ness P. Duration of ICU Delirium, Severity of the Underlying Disease, and Mortality. American Journal Of Respiratory And Critical Care Medicine 2010, 181: 420-421. DOI: 10.1164/ajrccm.181.4.420.
- Pisani MA, Kong SY, Kasl SV, Murphy TE, Araujo KL, Van Ness PH. Days of Delirium Are Associated with 1-Year Mortality in an Older Intensive Care Unit Population. American Journal Of Respiratory And Critical Care Medicine 2009, 180: 1092-1097. PMID: 19745202, PMCID: PMC2784414, DOI: 10.1164/rccm.200904-0537oc.
- Pisani MA, Murphy TE, Araujo KL, Slattum P, Van Ness PH, Inouye SK. Benzodiazepine and opioid use and the duration of intensive care unit delirium in an older population*. Critical Care Medicine 2009, 37: 177-183. PMID: 19050611, PMCID: PMC2700732, DOI: 10.1097/ccm.0b013e318192fcf9.
- Pisani MA. Analytic Reviews: Considerations in Caring for the Critically Ill Older Patient. Journal Of Intensive Care Medicine 2008, 24: 83-95. PMID: 19114416, DOI: 10.1177/0885066608329942.
- Pisani MA. Delirium assessment in the intensive care unit: patient population matters. Critical Care 2008, 12: 131. PMID: 18423059, PMCID: PMC2447584, DOI: 10.1186/cc6847.
- Pisani M. Preface. Clinics In Chest Medicine 2007, 28: ix. DOI: 10.1016/j.ccm.2007.08.009.
- Siner JM, Pisani MA. Mechanical Ventilation and Acute Respiratory Distress Syndrome in Older Patients. Clinics In Chest Medicine 2007, 28: 783-791. PMID: 17967294, DOI: 10.1016/j.ccm.2007.08.008.
- Cosgriff JA, Pisani M, Bradley EH, O’Leary J, Fried TR. The Association between Treatment Preferences and Trajectories of Care at the End-of-Life. Journal Of General Internal Medicine 2007, 22: 1566-1571. PMID: 17874168, PMCID: PMC2219807, DOI: 10.1007/s11606-007-0362-6.
- Pisani MA, Murphy TE, Van Ness PH, Araujo KL, Inouye SK. Characteristics Associated With Delirium in Older Patients in a Medical Intensive Care Unit. JAMA Internal Medicine 2007, 167: 1629-1634. PMID: 17698685, DOI: 10.1001/archinte.167.15.1629.
- Van Ness PH, Murphy TE, Araujo KL, Pisani MA, Allore HG. The use of missingness screens in clinical epidemiologic research has implications for regression modeling. Journal Of Clinical Epidemiology 2007, 60: 1239-1245. PMID: 17998078, PMCID: PMC2443713, DOI: 10.1016/j.jclinepi.2007.03.006.
- Pisani MA, Araujo K, Van Ness PH, Zhang Y, Ely E, Inouye SK. A research algorithm to improve detection of delirium in the intensive care unit. Critical Care 2006, 10: r121. PMID: 16919169, PMCID: PMC1750978, DOI: 10.1186/cc5027.
- Friedman LN, Nash ER, Bryant J, Henry S, Shi J, D'Amato J, Khaled GH, Russi MB, O'Connor PG, Edberg SC, Pisani MA, Cain HC, Tanoue L, Weissman DN. High Rate of Negative Results of Tuberculin and QuantiFERON Tests Among Individuals With a History of Positive Skin Test Results. Infection Control And Hospital Epidemiology 2006, 27: 436-441. PMID: 16671022, DOI: 10.1086/503690.
- Pisani M, Ely E. Chapter 6 Monitoring and Treatment of Pain, Anxiety, and Delirium in the ICU. 2006, 51-59. DOI: 10.1016/b978-0-323-02844-8.50011-1.
- D'Ambrosio C, Stachenfeld NS, Pisani M, Mohsenin V. Sleep, breathing, and menopause: The effect of fluctuating estrogen and progesterone on sleep and breathing in women. Gender Medicine 2005, 2: 238-245. PMID: 16464735, DOI: 10.1016/s1550-8579(05)80053-1.
- Pisani MA, Redlich CA, McNicoll L, Ely EW, Friedkin RJ, Inouye SK. Short-term outcomes in older intensive care unit patients with dementia*. Critical Care Medicine 2005, 33: 1371-1376. PMID: 15942358, DOI: 10.1097/01.ccm.0000165558.83676.48.
- McNicoll L, Pisani MA, Ely EW, Gifford D, Inouye SK. Detection of Delirium in the Intensive Care Unit: Comparison of Confusion Assessment Method for the Intensive Care Unit with Confusion Assessment Method Ratings. Journal Of The American Geriatrics Society 2005, 53: 495-500. PMID: 15743296, DOI: 10.1111/j.1532-5415.2005.53171.x.
- Pisani MA, Redlich C, McNicoll L, Ely EW, Inouye SK. Underrecognition of Preexisting Cognitive Impairment by Physicians in Older ICU Patients. CHEST Journal 2003, 124: 2267-2274. PMID: 14665510, DOI: 10.1378/chest.124.6.2267.
- Pisani MA, McNicoll L, Inouye SK. Cognitive impairment in the intensive care unit. Clinics In Chest Medicine 2003, 24: 727-737. PMID: 14710700, DOI: 10.1016/s0272-5231(03)00092-3.
- Pisani MA, Inouye SK, McNicoll L, Redlich CA. Screening for Preexisting Cognitive Impairment in Older Intensive Care Unit Patients: Use of Proxy Assessment. Journal Of The American Geriatrics Society 2003, 51: 689-693. PMID: 12752846, DOI: 10.1034/j.1600-0579.2003.00215.x.
- McNicoll L, Pisani MA, Zhang Y, Ely EW, Siegel MD, Inouye SK. Delirium in the Intensive Care Unit: Occurrence and Clinical Course in Older Patients. Journal Of The American Geriatrics Society 2003, 51: 591-598. PMID: 12752832, DOI: 10.1034/j.1600-0579.2003.00201.x.
- Moslehi F, Ligas JR, Pisani MA, Epstein MA. The unsteady form of the Bernoulli equation for estimating pressure drop in the airways. Respiration Physiology 1989, 76: 319-26. PMID: 2749031, DOI: 10.1016/0034-5687(89)90072-8.