Malini Harigopal, MD
Biography
Malini Harigopal, MD, is a pathologist who specializes in diagnosing breast cancer. During her breast fellowship training at Weill Cornell Medical center, she became interested in solving the most complicated breast cancer cases.
Dr. Harigopal understands how traumatic a diagnosis of breast cancer can be for patients. Even though pathologists do not routinely interact with patients, she makes herself available to answer any questions patients may have about their diagnosis. She also stresses the importance of pathologists with expertise in breast pathology who are highly specialized in reading breast specimens. She believes a deep understanding and experience in various breast diseases is absolutely necessary for accurate diagnosis. "I remember reviewing a patient's case where she had received a breast cancer diagnosis," Dr. Harigopal says. "But after looking closely at the biopsy, it was clear she did not have cancer." These cases highlight the importance of a second review of potentially malignant lesions in order to avoid over-diagnosis and unnecessary treatment.
At Yale School of Medicine, Dr. Harigopal is an associate professor of pathology and director of breast pathology. She has been recognized for her work in breast cancer and in human papillomavirus (HPV) research in cytology specimens.
Titles
- Professor of Pathology
- Director of Immunohistochemistry Lab, Pathology
Education & Training
- FellowNew York Presbyterian Hospital (2016)
- FellowNew York Presbyterian Hospital (2002)
- FellowNew York Presbyterian Hospital (2001)
- ResidentUniversity of Chicago Medical Center (2000)
- ResidentBrooklyn Hospital (1997)
- MDGandhi Medical College (1985)
Languages Spoken
- English
- हिन्दी (Hindi)
- தமிழ் (Tamil)
- తెలుగు (Telugu)
Additional Information
- HPV Investigation Award: American Society of Cytopathology (2016)
- Papanikolaou Society (2014 - 2016): Education committee for national residency and cytotechnology programs
- Wang M, Stendahl K, Cai G, Adeniran A, Harigopal M, Gilani SM. Evaluation of TRPS1 Expression in Pleural Effusion Cytology Specimens With Metastatic Breast Carcinoma. American Journal Of Clinical Pathology 2022, 158: 416-425. PMID: 35760555, DOI: 10.1093/ajcp/aqac066.
- Rozenblit M, Blenman K, Harigopal M, Reisenbichler E, Singh K, Qing T, Ibrahim E, Ramkissoon S, Asmelash S, Lin HK, Roberts M, Ross J, Huang RSP, Pusztai L. PD-L1 protein expression in relation to recurrence score values in early-stage ER + breast cancer. Breast Cancer Research And Treatment 2022 PMID: 36028784, DOI: 10.1007/s10549-022-06712-2.
- Dolezal D, Zhang X, Harigopal M. Increased Expression of LEF1 and β-Catenin in Invasive Micropapillary Carcinoma of the Breast is Associated with Lymphovascular Invasion and Lymph Node Metastasis. Applied Immunohistochemistry & Molecular Morphology : AIMM / Official Publication Of The Society For Applied Immunohistochemistry 2022 PMID: 35960138, DOI: 10.1097/PAI.0000000000001052.
- Sun T, Gilani SM, Podany P, Harigopal M, Zhong M, Wang H. Cytomorphologic features of SMARCA4-deficient non-small cell lung carcinoma and correlation with immunohistochemical and molecular features. Cancer Cytopathology 2022, 130: 620-629. PMID: 35468657, DOI: 10.1002/cncy.22581.
- Liang Y, Zhan H, Krishnamurti U, Harigopal M, Sun T. Further Characterization of Clinicopathologic Features of Cystic Neutrophilic Granulomatous Mastitis. American Journal Of Clinical Pathology 2022 PMID: 35899981, DOI: 10.1093/ajcp/aqac074.
- Moriarty K, Yu M, Hussain N, Zgutka K, Sanders MM, Harigopal M, Wang J, Wang X, Hui P, Liu C, Sink D, Shields A. COVID-19 & differential effects in twins: Insights from Placenta Pathology. Placenta 2022, 124: 62-66. PMID: 35640456, PMCID: PMC9121647, DOI: 10.1016/j.placenta.2022.05.014.
- McHenry A, Iyer K, Wang J, Liu C, Harigopal M. Detection of SARS-CoV-2 in tissue: the comparative roles of RT-qPCR, in situ RNA hybridization, and immunohistochemistry. Expert Review Of Molecular Diagnostics 2022, 22: 559-574. PMID: 35658709, DOI: 10.1080/14737159.2022.2085508.
- Fernandez AI, Liu M, Bellizzi A, Brock J, Fadare O, Hanley K, Harigopal M, Jorns JM, Kuba MG, Ly A, Podoll M, Rabe K, Sanders MA, Singh K, Snir OL, Soong TR, Wei S, Wen H, Wong S, Yoon E, Pusztai L, Reisenbichler E, Rimm DL. Examination of Low ERBB2 Protein Expression in Breast Cancer Tissue. JAMA Oncology 2022, 8: 1-4. PMID: 35113160, PMCID: PMC8814969, DOI: 10.1001/jamaoncol.2021.7239.
- Mantrala S, Ginter PS, Mitkar A, Joshi S, Prabhala H, Ramachandra V, Kini L, Idress R, D'Alfonso TM, Fineberg S, Jaffer S, Sattar AK, Chagpar AB, Wilson P, Singh K, Harigopal M, Koka D. Concordance in Breast Cancer Grading by Artificial Intelligence on Whole Slide Images Compares With a Multi-Institutional Cohort of Breast Pathologists. Archives Of Pathology & Laboratory Medicine 2022 PMID: 35271701, DOI: 10.5858/arpa.2021-0299-OA.
- Fineberg S, Tian X, Makower D, Harigopal M, Lo Y. EZH2 Protein Expression in Triple-negative Breast Cancer Treated With Neoadjuvant Chemotherapy: An Exploratory Study of Association With Tumor Response and Prognosis. Applied Immunohistochemistry & Molecular Morphology : AIMM / Official Publication Of The Society For Applied Immunohistochemistry 2022, 30: 157-164. PMID: 35262520, DOI: 10.1097/PAI.0000000000000998.
- Saridakis A, Berger ER, Harigopal M, Park T, Horowitz N, Le Blanc J, Zanieski G, Chagpar A, Greenup R, Golshan M, Lannin DR. Apocrine Breast Cancer: Unique Features of a Predominantly Triple-Negative Breast Cancer. Annals Of Surgical Oncology 2021, 28: 5610-5616. PMID: 34426884, DOI: 10.1245/s10434-021-10518-9.
- Singh K, Sardana R, Quddus MR, Harigopal M. Epithelium Involving Bilateral Axillary Lymph Nodes: Metastasis, Misplaced, or Mullerian! International Journal Of Surgical Pathology 2021, 29: 284-288. PMID: 32924678, DOI: 10.1177/1066896920958121.
- Ginter PS, Idress R, D'Alfonso TM, Fineberg S, Jaffer S, Sattar AK, Chagpar A, Wilson P, Harigopal M. Histologic grading of breast carcinoma: a multi-institution study of interobserver variation using virtual microscopy. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2021, 34: 701-709. PMID: 33077923, PMCID: PMC7987728, DOI: 10.1038/s41379-020-00698-2.
- Ko CJ, Harigopal M, Gehlhausen JR, Bosenberg M, McNiff JM, Damsky W. Discordant anti-SARS-CoV-2 spike protein and RNA staining in cutaneous perniotic lesions suggests endothelial deposition of cleaved spike protein. Journal Of Cutaneous Pathology 2021, 48: 47-52. PMID: 32895985, DOI: 10.1111/cup.13866.
- Balakrishnan R, Singh K, Harigopal M, Fineberg S. A Novel "Google Classroom"-Based Pathology Education Tool for Trainees During the COVID-19 Pandemic: Impactful Learning While Social Distancing. Archives Of Pathology & Laboratory Medicine 2020, 144: 1445b-1447. PMID: 32846431, DOI: 10.5858/arpa.2020-0476-LE.
- Ko CJ, Harigopal M, Damsky W, Gehlhausen JR, Bosenberg M, Patrignelli R, McNiff JM. Perniosis during the COVID-19 pandemic: Negative anti-SARS-CoV-2 immunohistochemistry in six patients and comparison to perniosis before the emergence of SARS-CoV-2. Journal Of Cutaneous Pathology 2020, 47: 997-1002. PMID: 32745281, PMCID: PMC7436569, DOI: 10.1111/cup.13830.
- Hosier H, Farhadian SF, Morotti RA, Deshmukh U, Lu-Culligan A, Campbell KH, Yasumoto Y, Vogels CB, Casanovas-Massana A, Vijayakumar P, Geng B, Odio CD, Fournier J, Brito AF, Fauver JR, Liu F, Alpert T, Tal R, Szigeti-Buck K, Perincheri S, Larsen C, Gariepy AM, Aguilar G, Fardelmann KL, Harigopal M, Taylor HS, Pettker CM, Wyllie AL, Dela Cruz CS, Ring AM, Grubaugh ND, Ko AI, Horvath TL, Iwasaki A, Reddy UM, Lipkind HS. SARS-CoV-2 infection of the placenta. The Journal Of Clinical Investigation 2020, 130: 4947-4953. PMID: 32573498, PMCID: PMC7456249, DOI: 10.1172/JCI139569.
- Malvi P, Janostiak R, Chava S, Manrai P, Yoon E, Singh K, Harigopal M, Gupta R, Wajapeyee N. LIMK2 promotes the metastatic progression of triple-negative breast cancer by activating SRPK1. Oncogenesis 2020, 9: 77. PMID: 32859889, PMCID: PMC7455732, DOI: 10.1038/s41389-020-00263-1.
- Harigopal M, Kowalski D, Vosoughi A. Enumeration and molecular characterization of circulating tumor cells as an innovative tool for companion diagnostics in breast cancer. Expert Review Of Molecular Diagnostics 2020, 20: 815-828. PMID: 32546017, DOI: 10.1080/14737159.2020.1784009.
- Yoon EC, Wilson P, Zuo T, Pinto M, Cole K, Harigopal M. High frequency of p16 and SOX10 coexpression but not androgen receptor expression in triple-negative breast cancers. Human Pathology 2020, 102: 13-22. PMID: 32565323, DOI: 10.1016/j.humpath.2020.06.004.
- Yaghoobi V, Martinez-Morilla S, Liu Y, Charette L, Rimm DL, Harigopal M. Advances in quantitative immunohistochemistry and their contribution to breast cancer. Expert Review Of Molecular Diagnostics 2020, 20: 509-522. PMID: 32178550, DOI: 10.1080/14737159.2020.1743178.
- Rabe K, Snir OL, Bossuyt V, Harigopal M, Celli R, Reisenbichler ES. Interobserver variability in breast carcinoma grading results in prognostic stage differences. Human Pathology 2019, 94: 51-57. PMID: 31655171, DOI: 10.1016/j.humpath.2019.09.006.
- Wilson PC, Chagpar AB, Cicek AF, Bossuyt V, Buza N, Mougalian S, Killelea BK, Patel N, Harigopal M. Breast cancer histopathology is predictive of low-risk Oncotype Dx recurrence score. The Breast Journal 2018, 24: 976-980. PMID: 30230117, DOI: 10.1111/tbj.13117.
- Szekely B, Bossuyt V, Li X, Wali VB, Patwardhan GA, Frederick C, Silber A, Park T, Harigopal M, Pelekanou V, Zhang M, Yan Q, Rimm DL, Bianchini G, Hatzis C, Pusztai L. Immunological differences between primary and metastatic breast cancer. Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / ESMO 2018, 29: 2232-2239. PMID: 30203045, DOI: 10.1093/annonc/mdy399.
- Zuo T, Wilson P, Cicek AF, Harigopal M. Androgen receptor expression is a favorable prognostic factor in triple-negative breast cancers. Human Pathology 2018, 80: 239-245. PMID: 29902579, DOI: 10.1016/j.humpath.2018.06.003.
- Janostiak R, Vyas M, Cicek AF, Wajapeyee N, Harigopal M. Loss of c-KIT expression in breast cancer correlates with malignant transformation of breast epithelium and is mediated by KIT gene promoter DNA hypermethylation. Experimental And Molecular Pathology 2018, 105: 41-49. PMID: 29852185, DOI: 10.1016/j.yexmp.2018.05.011.
- Boto A, Harigopal M. Strong androgen receptor expression can aid in distinguishing GATA3+ metastases. Human Pathology 2018, 75: 63-70. PMID: 29408697, DOI: 10.1016/j.humpath.2018.01.024.
- Dzimitrowicz H, Mougalian S, Storms S, Hurd S, Chagpar AB, Killelea BK, Horowitz NR, Lannin DR, Harigopal M, Hofstatter E, DiGiovanna MP, Adelson KB, Silber A, Abu-Khalaf M, Chung G, Zaheer W, Abdelghany O, Hatzis C, Pusztai L, Sanft TB. Impacts of Early Guideline-Directed 21-Gene Recurrence Score Testing on Adjuvant Therapy Decision Making. Journal Of Oncology Practice / American Society Of Clinical Oncology 2017, 13: e1012-e1020. PMID: 29048991, DOI: 10.1200/JOP.2017.022731.
- Chagpar AB, Cicek AF, Harigopal M. Can Tumor Biology Predict Occult Multifocal Disease in Breast Cancer Patients? The American Surgeon 2017, 83: 704-708. PMID: 28738939.
- Chagpar AB, Horowitz NR, Killelea BK, Tsangaris T, Longley P, Grizzle S, Loftus M, Li F, Butler M, Stavris K, Yao X, Harigopal M, Bossuyt V, Lannin DR, Pusztai L, Davidoff AJ, Gross CP. Economic Impact of Routine Cavity Margins Versus Standard Partial Mastectomy in Breast Cancer Patients: Results of a Randomized Controlled Trial. Annals Of Surgery 2017, 265: 39-44. PMID: 27192352, PMCID: PMC5605915, DOI: 10.1097/SLA.0000000000001799.
- Vyas M, Harigopal M. Metastatic thyroid carcinoma presenting as malignant pleural effusion: A cytologic review of 5 cases. Diagnostic Cytopathology 2016, 44: 1085-1089. PMID: 27456348, DOI: 10.1002/dc.23547.
- Zarrella ER, Coulter M, Welsh AW, Carvajal DE, Schalper KA, Harigopal M, L Rimm D, M Neumeister V. Automated measurement of estrogen receptor in breast cancer: a comparison of fluorescent and chromogenic methods of measurement. Laboratory Investigation; A Journal Of Technical Methods And Pathology 2016, 96: 1016-25. PMID: 27348626, PMCID: PMC5008858, DOI: 10.1038/labinvest.2016.73.
- Chagpar AB, Killelea BK, Tsangaris TN, Butler M, Stavris K, Li F, Yao X, Bossuyt V, Harigopal M, Lannin DR, Pusztai L, Horowitz NR. A Randomized, Controlled Trial of Cavity Shave Margins in Breast Cancer. The New England Journal Of Medicine 2015, 373: 503-10. PMID: 26028131, PMCID: PMC5584380, DOI: 10.1056/NEJMoa1504473.
- Brandsma JL, Harigopal M, Kiviat NB, Sun Y, Deng Y, Zelterman D, Lizardi PM, Shabanova VS, Levi A, Yaping T, Hu X, Feng Q. Methylation of twelve CpGs in human papillomavirus type 16 (HPV16) as an informative biomarker for the triage of women positive for HPV16 infection. Cancer Prevention Research (Philadelphia, Pa.) 2014, 7: 526-33. PMID: 24556390, DOI: 10.1158/1940-6207.CAPR-13-0354.
- Bernstein J, Adeniran AJ, Cai G, Theoharis CG, Ustun B, Beckman D, Aslanian HR, Harigopal M. Endoscopic ultrasound-guided fine-needle aspiration diagnosis of Merkel cell carcinoma metastatic to the pancreas. Diagnostic Cytopathology 2014, 42: 247-52. PMID: 22730170, DOI: 10.1002/dc.22884.
- Hafeez F, Neboori HJ, Harigopal M, Wu H, Haffty BG, Yang Q, Schiff D, Moran MS. Is Ki-67 expression prognostic for local relapse in early-stage breast cancer patients treated with breast conservation therapy (BCT)? International Journal Of Radiation Oncology, Biology, Physics 2013, 87: 344-8. PMID: 23910708, DOI: 10.1016/j.ijrobp.2013.05.052.
- Levy GH, Finkelstein A, Harigopal M, Chhieng D, Cai G. Cytoplasmic vacuolization: an under-recognized cytomorphologic feature in endocrine tumors of the pancreas. Diagnostic Cytopathology 2013, 41: 623-8. PMID: 22807461, DOI: 10.1002/dc.22893.
- Quantitative analysis of estrogen receptor expression shows SP1 antibody is more sensitive than 1D5.Welsh AW, Harigopal M, Wimberly H, Prasad M, Rimm DL. Quantitative analysis of estrogen receptor expression shows SP1 antibody is more sensitive than 1D5. Applied Immunohistochemistry & Molecular Morphology : AIMM / Official Publication Of The Society For Applied Immunohistochemistry 2013, 21: 139-47. PMID: 22820659, PMCID: PMC3482297, DOI: 10.1097/PAI.0b013e31825d73b2.
- Levi AW, Galullo P, Gordy K, Mikolaiski N, Schofield K, Elsheikh TM, Harigopal M, Chhieng DC. Increasing cytotechnologist workload above 100 slides per day using the BD FocalPoint GS imaging system negatively affects screening performance. American Journal Of Clinical Pathology 2012, 138: 811-5. PMID: 23161714, DOI: 10.1309/AJCPTYDD9G2NCUMF.
- Levi AW, Beckman D, Hui P, Schofield K, Harigopal M, Chhieng DC. Comparing two methods of detection for Chlamydia trachomatis in liquid-based Papanicolaou tests. American Journal Of Clinical Pathology 2012, 138: 236-40. PMID: 22904135, DOI: 10.1309/AJCP2B7XQTCNAMJP.
- Levi AW, Chhieng DC, Schofield K, Kowalski D, Harigopal M. Implementation of FocalPoint GS location-guided imaging system: experience in a clinical setting. Cancer Cytopathology 2012, 120: 126-33. PMID: 22505211, DOI: 10.1002/cncy.20187.
- Wong R, Levi AW, Harigopal M, Schofield K, Chhieng DC. The positive impact of simultaneous implementation of the BD FocalPoint GS Imaging System and lean principles on the operation of gynecologic cytology. Archives Of Pathology & Laboratory Medicine 2012, 136: 183-9. PMID: 22288966, DOI: 10.5858/arpa.2011-0139-OA.
- Levi AW, Harigopal M, Hui P, Schofield K, Chhieng DC. Use of high-risk human papillomavirus testing in patients with low-grade squamous intraepithelial lesions. Cancer Cytopathology 2011, 119: 228-34. PMID: 21732551, DOI: 10.1002/cncy.20172.
- Welsh AW, Moeder CB, Kumar S, Gershkovich P, Alarid ET, Harigopal M, Haffty BG, Rimm DL. Standardization of estrogen receptor measurement in breast cancer suggests false-negative results are a function of threshold intensity rather than percentage of positive cells. Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology 2011, 29: 2978-84. PMID: 21709197, PMCID: PMC3157961, DOI: 10.1200/JCO.2010.32.9706.
- Nagarajan P, Cai G, Padda MS, Selbst M, Kowalski D, Proctor DD, Chhieng D, Aslanian HR, Harigopal M. Littoral cell angioma of the spleen diagnosed by endoscopic ultrasound-guided fine-needle aspiration biopsy. Diagnostic Cytopathology 2011, 39: 318-22. PMID: 21488173, DOI: 10.1002/dc.21384.
- Levi AW, Harigopal M, Hui P, Schofield K, Chhieng DC. Comparison of Affirm VPIII and Papanicolaou tests in the detection of infectious vaginitis. American Journal Of Clinical Pathology 2011, 135: 442-7. PMID: 21350100, DOI: 10.1309/AJCP7TBN5VZUGLZU.
- Harigopal M, Barlow WE, Tedeschi G, Porter PL, Yeh IT, Haskell C, Livingston R, Hortobagyi GN, Sledge G, Shapiro C, Ingle JN, Rimm DL, Hayes DF. Multiplexed assessment of the Southwest Oncology Group-directed Intergroup Breast Cancer Trial S9313 by AQUA shows that both high and low levels of HER2 are associated with poor outcome. The American Journal Of Pathology 2010, 176: 1639-47. PMID: 20150438, PMCID: PMC2843456, DOI: 10.2353/ajpath.2010.090711.
- Brandsma JL, Sun Y, Lizardi PM, Tuck DP, Zelterman D, Haines GK, Martel M, Harigopal M, Schofield K, Neapolitano M. Distinct human papillomavirus type 16 methylomes in cervical cells at different stages of premalignancy. Virology 2009, 389: 100-7. PMID: 19443004, PMCID: PMC2918277, DOI: 10.1016/j.virol.2009.03.029.
- Harigopal M, Heymann J, Ghosh S, Anagnostou V, Camp RL, Rimm DL. Estrogen receptor co-activator (AIB1) protein expression by automated quantitative analysis (AQUA) in a breast cancer tissue microarray and association with patient outcome. Breast Cancer Research And Treatment 2009, 115: 77-85. PMID: 18521745, DOI: 10.1007/s10549-008-0063-9.
- Moeder CB, Giltnane JM, Harigopal M, Molinaro A, Robinson A, Gelmon K, Huntsman D, Camp RL, Rimm DL. Quantitative justification of the change from 10% to 30% for human epidermal growth factor receptor 2 scoring in the American Society of Clinical Oncology/College of American Pathologists guidelines: tumor heterogeneity in breast cancer and its implications for tissue microarray based assessment of outcome. Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology 2007, 25: 5418-25. PMID: 18048824, DOI: 10.1200/JCO.2007.12.8033.
- Sherman ME, Rimm DL, Yang XR, Chatterjee N, Brinton LA, Lissowska J, Peplonska B, Szeszenia-Dabrowska N, Zatonski W, Cartun R, Mandich D, Rymkiewicz G, Ligaj M, Lukaszek S, Kordek R, Kalaylioglu Z, Harigopal M, Charrette L, Falk RT, Richesson D, Anderson WF, Hewitt SM, García-Closas M. Variation in breast cancer hormone receptor and HER2 levels by etiologic factors: a population-based analysis. International Journal Of Cancer. Journal International Du Cancer 2007, 121: 1079-85. PMID: 17487843, DOI: 10.1002/ijc.22812.
- Rimm DL, Giltnane JM, Moeder C, Harigopal M, Chung GG, Camp RL, Burtness B. Bimodal population or pathologist artifact? Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology 2007, 25: 2487-8. PMID: 17557963, DOI: 10.1200/JCO.2006.07.7537.
- Dolled-Filhart M, Rydén L, Cregger M, Jirström K, Harigopal M, Camp RL, Rimm DL. Classification of breast cancer using genetic algorithms and tissue microarrays. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2006, 12: 6459-68. PMID: 17085660, DOI: 10.1158/1078-0432.CCR-06-1383.
- Chung GG, Yoon HH, Zerkowski MP, Ghosh S, Thomas L, Harigopal M, Charette LA, Salem RR, Camp RL, Rimm DL, Burtness BA. Vascular endothelial growth factor, FLT-1, and FLK-1 analysis in a pancreatic cancer tissue microarray. Cancer 2006, 106: 1677-84. PMID: 16532435, DOI: 10.1002/cncr.21783.
- Weinberger PM, Yu Z, Haffty BG, Kowalski D, Harigopal M, Brandsma J, Sasaki C, Joe J, Camp RL, Rimm DL, Psyrri A. Molecular classification identifies a subset of human papillomavirus--associated oropharyngeal cancers with favorable prognosis. Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology 2006, 24: 736-47. PMID: 16401683, DOI: 10.1200/JCO.2004.00.3335.
- Harigopal M, Shin SJ, Murray MP, Tickoo SK, Brogi E, Rosen PP. Aberrant E-cadherin staining patterns in invasive mammary carcinoma. World Journal Of Surgical Oncology 2005, 3: 73. PMID: 16287501, PMCID: PMC1308872, DOI: 10.1186/1477-7819-3-73.
- Harigopal M, Berger AJ, Camp RL, Rimm DL, Kluger HM. Automated quantitative analysis of E-cadherin expression in lymph node metastases is predictive of survival in invasive ductal breast cancer. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2005, 11: 4083-9. PMID: 15930343, DOI: 10.1158/1078-0432.CCR-04-2191.
- Handerson T, Camp R, Harigopal M, Rimm D, Pawelek J. Beta1,6-branched oligosaccharides are increased in lymph node metastases and predict poor outcome in breast carcinoma. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2005, 11: 2969-73. PMID: 15837749, DOI: 10.1158/1078-0432.CCR-04-2211.
- Harigopal M, Murray MP, Rosen PP, Shin SJ. Prepubertal gynecomastia with lobular differentiation. The Breast Journal 2005, 11: 48-51. PMID: 15647078, DOI: 10.1111/j.1075-122X.2005.21442.x.
- Hoda SA, Harigopal M. Distinctive calcific deposits in pregnancy-like hyperplasia. The Breast Journal 2004, 10: 551. PMID: 15569218, DOI: 10.1111/j.1075-122X.2004.21385.x.
- Weinberger PM, Yu Z, Haffty BG, Kowalski D, Harigopal M, Sasaki C, Rimm DL, Psyrri A. Prognostic significance of p16 protein levels in oropharyngeal squamous cell cancer. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2004, 10: 5684-91. PMID: 15355894, DOI: 10.1158/1078-0432.CCR-04-0448.
- Pirog EC, Erroll M, Harigopal M, Centeno BA. Comparison of human papillomavirus DNA prevalence in atypical squamous cells of undetermined significance subcategories as defined by the original Bethesda 1991 and the new Bethesda 2001 Systems. Archives Of Pathology & Laboratory Medicine 2004, 128: 527-32. PMID: 15086283, DOI: 10.5858/2004-128-527-COHPDP.
- Harigopal M, Sahoo S, Recant WM, DeMay RM. Fine-needle aspiration of Riedel's disease: report of a case and review of the literature. Diagnostic Cytopathology 2004, 30: 193-7. PMID: 14986301, DOI: 10.1002/dc.10420.
- Harigopal M, Park K, Chen X, Rosen PP. Pathologic quiz case: a rapidly increasing breast mass in a postmenopausal woman. Malignant adenomyoepithelioma. Archives Of Pathology & Laboratory Medicine 2004, 128: 235-6. PMID: 14736274, DOI: 10.5858/2004-128-235-PQCARI.
- Harigopal M, Hoda SA, Seshan SV. Images in pathology: congo-red negative fibrillary glomerulonephritis. International Journal Of Surgical Pathology 2003, 11: 313. PMID: 14615827, DOI: 10.1177/106689690301100409.
- Harigopal M, Hoda SA. Images in pathology: inclusion bodies in phyllodes tumor of breast. International Journal Of Surgical Pathology 2003, 11: 220. PMID: 12894356, DOI: 10.1177/106689690301100311.
- Harigopal M, Mudrovich SA, Hoda SA, Rosen PP. Secondary tumors in mammary adenolipomas: a report of 2 unusual cases. Archives Of Pathology & Laboratory Medicine 2003, 127: e151-4. PMID: 12653605, DOI: 10.5858/2003-127-e151-STIMAA.
- Yao DX, Hoda SA, Yin DY, Kuhel WI, Harigopal M, Resetkova E, DeLellis RA. Interpretative problems and preparative technique influence reliability of intraoperative parathyroid touch imprints. Archives Of Pathology & Laboratory Medicine 2003, 127: 64-7. PMID: 12521369, DOI: 10.5858/2003-127-64-IPAPTI.
- Hoda SA, Chiu A, Resetkova E, Harigopal M, Hoda RS, Osborne MP. Pathological examination of sentinel lymph node in breast cancer: potential problems and possible solutions. Microscopy Research And Technique 2002, 59: 85-91. PMID: 12373718, DOI: 10.1002/jemt.10179.
- Harigopal M, Seshan SV, DeLellis RA, Yankelevitz D, Vazquez M. Aspiration cytology of elastofibroma dorsi: case report with ultrastructural and immunohistochemical findings. Diagnostic Cytopathology 2002, 26: 310-3. PMID: 11992374, DOI: 10.1002/dc.10106.
Biography
Malini Harigopal, MD, is a pathologist who specializes in diagnosing breast cancer. During her breast fellowship training at Weill Cornell Medical center, she became interested in solving the most complicated breast cancer cases.
Dr. Harigopal understands how traumatic a diagnosis of breast cancer can be for patients. Even though pathologists do not routinely interact with patients, she makes herself available to answer any questions patients may have about their diagnosis. She also stresses the importance of pathologists with expertise in breast pathology who are highly specialized in reading breast specimens. She believes a deep understanding and experience in various breast diseases is absolutely necessary for accurate diagnosis. "I remember reviewing a patient's case where she had received a breast cancer diagnosis," Dr. Harigopal says. "But after looking closely at the biopsy, it was clear she did not have cancer." These cases highlight the importance of a second review of potentially malignant lesions in order to avoid over-diagnosis and unnecessary treatment.
At Yale School of Medicine, Dr. Harigopal is an associate professor of pathology and director of breast pathology. She has been recognized for her work in breast cancer and in human papillomavirus (HPV) research in cytology specimens.
Titles
- Professor of Pathology
- Director of Immunohistochemistry Lab, Pathology
Education & Training
- FellowNew York Presbyterian Hospital (2016)
- FellowNew York Presbyterian Hospital (2002)
- FellowNew York Presbyterian Hospital (2001)
- ResidentUniversity of Chicago Medical Center (2000)
- ResidentBrooklyn Hospital (1997)
- MDGandhi Medical College (1985)
Languages Spoken
- English
- हिन्दी (Hindi)
- தமிழ் (Tamil)
- తెలుగు (Telugu)
Additional Information
- HPV Investigation Award: American Society of Cytopathology (2016)
- Papanikolaou Society (2014 - 2016): Education committee for national residency and cytotechnology programs
- Wang M, Stendahl K, Cai G, Adeniran A, Harigopal M, Gilani SM. Evaluation of TRPS1 Expression in Pleural Effusion Cytology Specimens With Metastatic Breast Carcinoma. American Journal Of Clinical Pathology 2022, 158: 416-425. PMID: 35760555, DOI: 10.1093/ajcp/aqac066.
- Rozenblit M, Blenman K, Harigopal M, Reisenbichler E, Singh K, Qing T, Ibrahim E, Ramkissoon S, Asmelash S, Lin HK, Roberts M, Ross J, Huang RSP, Pusztai L. PD-L1 protein expression in relation to recurrence score values in early-stage ER + breast cancer. Breast Cancer Research And Treatment 2022 PMID: 36028784, DOI: 10.1007/s10549-022-06712-2.
- Dolezal D, Zhang X, Harigopal M. Increased Expression of LEF1 and β-Catenin in Invasive Micropapillary Carcinoma of the Breast is Associated with Lymphovascular Invasion and Lymph Node Metastasis. Applied Immunohistochemistry & Molecular Morphology : AIMM / Official Publication Of The Society For Applied Immunohistochemistry 2022 PMID: 35960138, DOI: 10.1097/PAI.0000000000001052.
- Sun T, Gilani SM, Podany P, Harigopal M, Zhong M, Wang H. Cytomorphologic features of SMARCA4-deficient non-small cell lung carcinoma and correlation with immunohistochemical and molecular features. Cancer Cytopathology 2022, 130: 620-629. PMID: 35468657, DOI: 10.1002/cncy.22581.
- Liang Y, Zhan H, Krishnamurti U, Harigopal M, Sun T. Further Characterization of Clinicopathologic Features of Cystic Neutrophilic Granulomatous Mastitis. American Journal Of Clinical Pathology 2022 PMID: 35899981, DOI: 10.1093/ajcp/aqac074.
- Moriarty K, Yu M, Hussain N, Zgutka K, Sanders MM, Harigopal M, Wang J, Wang X, Hui P, Liu C, Sink D, Shields A. COVID-19 & differential effects in twins: Insights from Placenta Pathology. Placenta 2022, 124: 62-66. PMID: 35640456, PMCID: PMC9121647, DOI: 10.1016/j.placenta.2022.05.014.
- McHenry A, Iyer K, Wang J, Liu C, Harigopal M. Detection of SARS-CoV-2 in tissue: the comparative roles of RT-qPCR, in situ RNA hybridization, and immunohistochemistry. Expert Review Of Molecular Diagnostics 2022, 22: 559-574. PMID: 35658709, DOI: 10.1080/14737159.2022.2085508.
- Fernandez AI, Liu M, Bellizzi A, Brock J, Fadare O, Hanley K, Harigopal M, Jorns JM, Kuba MG, Ly A, Podoll M, Rabe K, Sanders MA, Singh K, Snir OL, Soong TR, Wei S, Wen H, Wong S, Yoon E, Pusztai L, Reisenbichler E, Rimm DL. Examination of Low ERBB2 Protein Expression in Breast Cancer Tissue. JAMA Oncology 2022, 8: 1-4. PMID: 35113160, PMCID: PMC8814969, DOI: 10.1001/jamaoncol.2021.7239.
- Mantrala S, Ginter PS, Mitkar A, Joshi S, Prabhala H, Ramachandra V, Kini L, Idress R, D'Alfonso TM, Fineberg S, Jaffer S, Sattar AK, Chagpar AB, Wilson P, Singh K, Harigopal M, Koka D. Concordance in Breast Cancer Grading by Artificial Intelligence on Whole Slide Images Compares With a Multi-Institutional Cohort of Breast Pathologists. Archives Of Pathology & Laboratory Medicine 2022 PMID: 35271701, DOI: 10.5858/arpa.2021-0299-OA.
- Fineberg S, Tian X, Makower D, Harigopal M, Lo Y. EZH2 Protein Expression in Triple-negative Breast Cancer Treated With Neoadjuvant Chemotherapy: An Exploratory Study of Association With Tumor Response and Prognosis. Applied Immunohistochemistry & Molecular Morphology : AIMM / Official Publication Of The Society For Applied Immunohistochemistry 2022, 30: 157-164. PMID: 35262520, DOI: 10.1097/PAI.0000000000000998.
- Saridakis A, Berger ER, Harigopal M, Park T, Horowitz N, Le Blanc J, Zanieski G, Chagpar A, Greenup R, Golshan M, Lannin DR. Apocrine Breast Cancer: Unique Features of a Predominantly Triple-Negative Breast Cancer. Annals Of Surgical Oncology 2021, 28: 5610-5616. PMID: 34426884, DOI: 10.1245/s10434-021-10518-9.
- Singh K, Sardana R, Quddus MR, Harigopal M. Epithelium Involving Bilateral Axillary Lymph Nodes: Metastasis, Misplaced, or Mullerian! International Journal Of Surgical Pathology 2021, 29: 284-288. PMID: 32924678, DOI: 10.1177/1066896920958121.
- Ginter PS, Idress R, D'Alfonso TM, Fineberg S, Jaffer S, Sattar AK, Chagpar A, Wilson P, Harigopal M. Histologic grading of breast carcinoma: a multi-institution study of interobserver variation using virtual microscopy. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2021, 34: 701-709. PMID: 33077923, PMCID: PMC7987728, DOI: 10.1038/s41379-020-00698-2.
- Ko CJ, Harigopal M, Gehlhausen JR, Bosenberg M, McNiff JM, Damsky W. Discordant anti-SARS-CoV-2 spike protein and RNA staining in cutaneous perniotic lesions suggests endothelial deposition of cleaved spike protein. Journal Of Cutaneous Pathology 2021, 48: 47-52. PMID: 32895985, DOI: 10.1111/cup.13866.
- Balakrishnan R, Singh K, Harigopal M, Fineberg S. A Novel "Google Classroom"-Based Pathology Education Tool for Trainees During the COVID-19 Pandemic: Impactful Learning While Social Distancing. Archives Of Pathology & Laboratory Medicine 2020, 144: 1445b-1447. PMID: 32846431, DOI: 10.5858/arpa.2020-0476-LE.
- Ko CJ, Harigopal M, Damsky W, Gehlhausen JR, Bosenberg M, Patrignelli R, McNiff JM. Perniosis during the COVID-19 pandemic: Negative anti-SARS-CoV-2 immunohistochemistry in six patients and comparison to perniosis before the emergence of SARS-CoV-2. Journal Of Cutaneous Pathology 2020, 47: 997-1002. PMID: 32745281, PMCID: PMC7436569, DOI: 10.1111/cup.13830.
- Hosier H, Farhadian SF, Morotti RA, Deshmukh U, Lu-Culligan A, Campbell KH, Yasumoto Y, Vogels CB, Casanovas-Massana A, Vijayakumar P, Geng B, Odio CD, Fournier J, Brito AF, Fauver JR, Liu F, Alpert T, Tal R, Szigeti-Buck K, Perincheri S, Larsen C, Gariepy AM, Aguilar G, Fardelmann KL, Harigopal M, Taylor HS, Pettker CM, Wyllie AL, Dela Cruz CS, Ring AM, Grubaugh ND, Ko AI, Horvath TL, Iwasaki A, Reddy UM, Lipkind HS. SARS-CoV-2 infection of the placenta. The Journal Of Clinical Investigation 2020, 130: 4947-4953. PMID: 32573498, PMCID: PMC7456249, DOI: 10.1172/JCI139569.
- Malvi P, Janostiak R, Chava S, Manrai P, Yoon E, Singh K, Harigopal M, Gupta R, Wajapeyee N. LIMK2 promotes the metastatic progression of triple-negative breast cancer by activating SRPK1. Oncogenesis 2020, 9: 77. PMID: 32859889, PMCID: PMC7455732, DOI: 10.1038/s41389-020-00263-1.
- Harigopal M, Kowalski D, Vosoughi A. Enumeration and molecular characterization of circulating tumor cells as an innovative tool for companion diagnostics in breast cancer. Expert Review Of Molecular Diagnostics 2020, 20: 815-828. PMID: 32546017, DOI: 10.1080/14737159.2020.1784009.
- Yoon EC, Wilson P, Zuo T, Pinto M, Cole K, Harigopal M. High frequency of p16 and SOX10 coexpression but not androgen receptor expression in triple-negative breast cancers. Human Pathology 2020, 102: 13-22. PMID: 32565323, DOI: 10.1016/j.humpath.2020.06.004.
- Yaghoobi V, Martinez-Morilla S, Liu Y, Charette L, Rimm DL, Harigopal M. Advances in quantitative immunohistochemistry and their contribution to breast cancer. Expert Review Of Molecular Diagnostics 2020, 20: 509-522. PMID: 32178550, DOI: 10.1080/14737159.2020.1743178.
- Rabe K, Snir OL, Bossuyt V, Harigopal M, Celli R, Reisenbichler ES. Interobserver variability in breast carcinoma grading results in prognostic stage differences. Human Pathology 2019, 94: 51-57. PMID: 31655171, DOI: 10.1016/j.humpath.2019.09.006.
- Wilson PC, Chagpar AB, Cicek AF, Bossuyt V, Buza N, Mougalian S, Killelea BK, Patel N, Harigopal M. Breast cancer histopathology is predictive of low-risk Oncotype Dx recurrence score. The Breast Journal 2018, 24: 976-980. PMID: 30230117, DOI: 10.1111/tbj.13117.
- Szekely B, Bossuyt V, Li X, Wali VB, Patwardhan GA, Frederick C, Silber A, Park T, Harigopal M, Pelekanou V, Zhang M, Yan Q, Rimm DL, Bianchini G, Hatzis C, Pusztai L. Immunological differences between primary and metastatic breast cancer. Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / ESMO 2018, 29: 2232-2239. PMID: 30203045, DOI: 10.1093/annonc/mdy399.
- Zuo T, Wilson P, Cicek AF, Harigopal M. Androgen receptor expression is a favorable prognostic factor in triple-negative breast cancers. Human Pathology 2018, 80: 239-245. PMID: 29902579, DOI: 10.1016/j.humpath.2018.06.003.
- Janostiak R, Vyas M, Cicek AF, Wajapeyee N, Harigopal M. Loss of c-KIT expression in breast cancer correlates with malignant transformation of breast epithelium and is mediated by KIT gene promoter DNA hypermethylation. Experimental And Molecular Pathology 2018, 105: 41-49. PMID: 29852185, DOI: 10.1016/j.yexmp.2018.05.011.
- Boto A, Harigopal M. Strong androgen receptor expression can aid in distinguishing GATA3+ metastases. Human Pathology 2018, 75: 63-70. PMID: 29408697, DOI: 10.1016/j.humpath.2018.01.024.
- Dzimitrowicz H, Mougalian S, Storms S, Hurd S, Chagpar AB, Killelea BK, Horowitz NR, Lannin DR, Harigopal M, Hofstatter E, DiGiovanna MP, Adelson KB, Silber A, Abu-Khalaf M, Chung G, Zaheer W, Abdelghany O, Hatzis C, Pusztai L, Sanft TB. Impacts of Early Guideline-Directed 21-Gene Recurrence Score Testing on Adjuvant Therapy Decision Making. Journal Of Oncology Practice / American Society Of Clinical Oncology 2017, 13: e1012-e1020. PMID: 29048991, DOI: 10.1200/JOP.2017.022731.
- Chagpar AB, Cicek AF, Harigopal M. Can Tumor Biology Predict Occult Multifocal Disease in Breast Cancer Patients? The American Surgeon 2017, 83: 704-708. PMID: 28738939.
- Chagpar AB, Horowitz NR, Killelea BK, Tsangaris T, Longley P, Grizzle S, Loftus M, Li F, Butler M, Stavris K, Yao X, Harigopal M, Bossuyt V, Lannin DR, Pusztai L, Davidoff AJ, Gross CP. Economic Impact of Routine Cavity Margins Versus Standard Partial Mastectomy in Breast Cancer Patients: Results of a Randomized Controlled Trial. Annals Of Surgery 2017, 265: 39-44. PMID: 27192352, PMCID: PMC5605915, DOI: 10.1097/SLA.0000000000001799.
- Vyas M, Harigopal M. Metastatic thyroid carcinoma presenting as malignant pleural effusion: A cytologic review of 5 cases. Diagnostic Cytopathology 2016, 44: 1085-1089. PMID: 27456348, DOI: 10.1002/dc.23547.
- Zarrella ER, Coulter M, Welsh AW, Carvajal DE, Schalper KA, Harigopal M, L Rimm D, M Neumeister V. Automated measurement of estrogen receptor in breast cancer: a comparison of fluorescent and chromogenic methods of measurement. Laboratory Investigation; A Journal Of Technical Methods And Pathology 2016, 96: 1016-25. PMID: 27348626, PMCID: PMC5008858, DOI: 10.1038/labinvest.2016.73.
- Chagpar AB, Killelea BK, Tsangaris TN, Butler M, Stavris K, Li F, Yao X, Bossuyt V, Harigopal M, Lannin DR, Pusztai L, Horowitz NR. A Randomized, Controlled Trial of Cavity Shave Margins in Breast Cancer. The New England Journal Of Medicine 2015, 373: 503-10. PMID: 26028131, PMCID: PMC5584380, DOI: 10.1056/NEJMoa1504473.
- Brandsma JL, Harigopal M, Kiviat NB, Sun Y, Deng Y, Zelterman D, Lizardi PM, Shabanova VS, Levi A, Yaping T, Hu X, Feng Q. Methylation of twelve CpGs in human papillomavirus type 16 (HPV16) as an informative biomarker for the triage of women positive for HPV16 infection. Cancer Prevention Research (Philadelphia, Pa.) 2014, 7: 526-33. PMID: 24556390, DOI: 10.1158/1940-6207.CAPR-13-0354.
- Bernstein J, Adeniran AJ, Cai G, Theoharis CG, Ustun B, Beckman D, Aslanian HR, Harigopal M. Endoscopic ultrasound-guided fine-needle aspiration diagnosis of Merkel cell carcinoma metastatic to the pancreas. Diagnostic Cytopathology 2014, 42: 247-52. PMID: 22730170, DOI: 10.1002/dc.22884.
- Hafeez F, Neboori HJ, Harigopal M, Wu H, Haffty BG, Yang Q, Schiff D, Moran MS. Is Ki-67 expression prognostic for local relapse in early-stage breast cancer patients treated with breast conservation therapy (BCT)? International Journal Of Radiation Oncology, Biology, Physics 2013, 87: 344-8. PMID: 23910708, DOI: 10.1016/j.ijrobp.2013.05.052.
- Levy GH, Finkelstein A, Harigopal M, Chhieng D, Cai G. Cytoplasmic vacuolization: an under-recognized cytomorphologic feature in endocrine tumors of the pancreas. Diagnostic Cytopathology 2013, 41: 623-8. PMID: 22807461, DOI: 10.1002/dc.22893.
- Quantitative analysis of estrogen receptor expression shows SP1 antibody is more sensitive than 1D5.Welsh AW, Harigopal M, Wimberly H, Prasad M, Rimm DL. Quantitative analysis of estrogen receptor expression shows SP1 antibody is more sensitive than 1D5. Applied Immunohistochemistry & Molecular Morphology : AIMM / Official Publication Of The Society For Applied Immunohistochemistry 2013, 21: 139-47. PMID: 22820659, PMCID: PMC3482297, DOI: 10.1097/PAI.0b013e31825d73b2.
- Levi AW, Galullo P, Gordy K, Mikolaiski N, Schofield K, Elsheikh TM, Harigopal M, Chhieng DC. Increasing cytotechnologist workload above 100 slides per day using the BD FocalPoint GS imaging system negatively affects screening performance. American Journal Of Clinical Pathology 2012, 138: 811-5. PMID: 23161714, DOI: 10.1309/AJCPTYDD9G2NCUMF.
- Levi AW, Beckman D, Hui P, Schofield K, Harigopal M, Chhieng DC. Comparing two methods of detection for Chlamydia trachomatis in liquid-based Papanicolaou tests. American Journal Of Clinical Pathology 2012, 138: 236-40. PMID: 22904135, DOI: 10.1309/AJCP2B7XQTCNAMJP.
- Levi AW, Chhieng DC, Schofield K, Kowalski D, Harigopal M. Implementation of FocalPoint GS location-guided imaging system: experience in a clinical setting. Cancer Cytopathology 2012, 120: 126-33. PMID: 22505211, DOI: 10.1002/cncy.20187.
- Wong R, Levi AW, Harigopal M, Schofield K, Chhieng DC. The positive impact of simultaneous implementation of the BD FocalPoint GS Imaging System and lean principles on the operation of gynecologic cytology. Archives Of Pathology & Laboratory Medicine 2012, 136: 183-9. PMID: 22288966, DOI: 10.5858/arpa.2011-0139-OA.
- Levi AW, Harigopal M, Hui P, Schofield K, Chhieng DC. Use of high-risk human papillomavirus testing in patients with low-grade squamous intraepithelial lesions. Cancer Cytopathology 2011, 119: 228-34. PMID: 21732551, DOI: 10.1002/cncy.20172.
- Welsh AW, Moeder CB, Kumar S, Gershkovich P, Alarid ET, Harigopal M, Haffty BG, Rimm DL. Standardization of estrogen receptor measurement in breast cancer suggests false-negative results are a function of threshold intensity rather than percentage of positive cells. Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology 2011, 29: 2978-84. PMID: 21709197, PMCID: PMC3157961, DOI: 10.1200/JCO.2010.32.9706.
- Nagarajan P, Cai G, Padda MS, Selbst M, Kowalski D, Proctor DD, Chhieng D, Aslanian HR, Harigopal M. Littoral cell angioma of the spleen diagnosed by endoscopic ultrasound-guided fine-needle aspiration biopsy. Diagnostic Cytopathology 2011, 39: 318-22. PMID: 21488173, DOI: 10.1002/dc.21384.
- Levi AW, Harigopal M, Hui P, Schofield K, Chhieng DC. Comparison of Affirm VPIII and Papanicolaou tests in the detection of infectious vaginitis. American Journal Of Clinical Pathology 2011, 135: 442-7. PMID: 21350100, DOI: 10.1309/AJCP7TBN5VZUGLZU.
- Harigopal M, Barlow WE, Tedeschi G, Porter PL, Yeh IT, Haskell C, Livingston R, Hortobagyi GN, Sledge G, Shapiro C, Ingle JN, Rimm DL, Hayes DF. Multiplexed assessment of the Southwest Oncology Group-directed Intergroup Breast Cancer Trial S9313 by AQUA shows that both high and low levels of HER2 are associated with poor outcome. The American Journal Of Pathology 2010, 176: 1639-47. PMID: 20150438, PMCID: PMC2843456, DOI: 10.2353/ajpath.2010.090711.
- Brandsma JL, Sun Y, Lizardi PM, Tuck DP, Zelterman D, Haines GK, Martel M, Harigopal M, Schofield K, Neapolitano M. Distinct human papillomavirus type 16 methylomes in cervical cells at different stages of premalignancy. Virology 2009, 389: 100-7. PMID: 19443004, PMCID: PMC2918277, DOI: 10.1016/j.virol.2009.03.029.
- Harigopal M, Heymann J, Ghosh S, Anagnostou V, Camp RL, Rimm DL. Estrogen receptor co-activator (AIB1) protein expression by automated quantitative analysis (AQUA) in a breast cancer tissue microarray and association with patient outcome. Breast Cancer Research And Treatment 2009, 115: 77-85. PMID: 18521745, DOI: 10.1007/s10549-008-0063-9.
- Moeder CB, Giltnane JM, Harigopal M, Molinaro A, Robinson A, Gelmon K, Huntsman D, Camp RL, Rimm DL. Quantitative justification of the change from 10% to 30% for human epidermal growth factor receptor 2 scoring in the American Society of Clinical Oncology/College of American Pathologists guidelines: tumor heterogeneity in breast cancer and its implications for tissue microarray based assessment of outcome. Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology 2007, 25: 5418-25. PMID: 18048824, DOI: 10.1200/JCO.2007.12.8033.
- Sherman ME, Rimm DL, Yang XR, Chatterjee N, Brinton LA, Lissowska J, Peplonska B, Szeszenia-Dabrowska N, Zatonski W, Cartun R, Mandich D, Rymkiewicz G, Ligaj M, Lukaszek S, Kordek R, Kalaylioglu Z, Harigopal M, Charrette L, Falk RT, Richesson D, Anderson WF, Hewitt SM, García-Closas M. Variation in breast cancer hormone receptor and HER2 levels by etiologic factors: a population-based analysis. International Journal Of Cancer. Journal International Du Cancer 2007, 121: 1079-85. PMID: 17487843, DOI: 10.1002/ijc.22812.
- Rimm DL, Giltnane JM, Moeder C, Harigopal M, Chung GG, Camp RL, Burtness B. Bimodal population or pathologist artifact? Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology 2007, 25: 2487-8. PMID: 17557963, DOI: 10.1200/JCO.2006.07.7537.
- Dolled-Filhart M, Rydén L, Cregger M, Jirström K, Harigopal M, Camp RL, Rimm DL. Classification of breast cancer using genetic algorithms and tissue microarrays. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2006, 12: 6459-68. PMID: 17085660, DOI: 10.1158/1078-0432.CCR-06-1383.
- Chung GG, Yoon HH, Zerkowski MP, Ghosh S, Thomas L, Harigopal M, Charette LA, Salem RR, Camp RL, Rimm DL, Burtness BA. Vascular endothelial growth factor, FLT-1, and FLK-1 analysis in a pancreatic cancer tissue microarray. Cancer 2006, 106: 1677-84. PMID: 16532435, DOI: 10.1002/cncr.21783.
- Weinberger PM, Yu Z, Haffty BG, Kowalski D, Harigopal M, Brandsma J, Sasaki C, Joe J, Camp RL, Rimm DL, Psyrri A. Molecular classification identifies a subset of human papillomavirus--associated oropharyngeal cancers with favorable prognosis. Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology 2006, 24: 736-47. PMID: 16401683, DOI: 10.1200/JCO.2004.00.3335.
- Harigopal M, Shin SJ, Murray MP, Tickoo SK, Brogi E, Rosen PP. Aberrant E-cadherin staining patterns in invasive mammary carcinoma. World Journal Of Surgical Oncology 2005, 3: 73. PMID: 16287501, PMCID: PMC1308872, DOI: 10.1186/1477-7819-3-73.
- Harigopal M, Berger AJ, Camp RL, Rimm DL, Kluger HM. Automated quantitative analysis of E-cadherin expression in lymph node metastases is predictive of survival in invasive ductal breast cancer. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2005, 11: 4083-9. PMID: 15930343, DOI: 10.1158/1078-0432.CCR-04-2191.
- Handerson T, Camp R, Harigopal M, Rimm D, Pawelek J. Beta1,6-branched oligosaccharides are increased in lymph node metastases and predict poor outcome in breast carcinoma. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2005, 11: 2969-73. PMID: 15837749, DOI: 10.1158/1078-0432.CCR-04-2211.
- Harigopal M, Murray MP, Rosen PP, Shin SJ. Prepubertal gynecomastia with lobular differentiation. The Breast Journal 2005, 11: 48-51. PMID: 15647078, DOI: 10.1111/j.1075-122X.2005.21442.x.
- Hoda SA, Harigopal M. Distinctive calcific deposits in pregnancy-like hyperplasia. The Breast Journal 2004, 10: 551. PMID: 15569218, DOI: 10.1111/j.1075-122X.2004.21385.x.
- Weinberger PM, Yu Z, Haffty BG, Kowalski D, Harigopal M, Sasaki C, Rimm DL, Psyrri A. Prognostic significance of p16 protein levels in oropharyngeal squamous cell cancer. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2004, 10: 5684-91. PMID: 15355894, DOI: 10.1158/1078-0432.CCR-04-0448.
- Pirog EC, Erroll M, Harigopal M, Centeno BA. Comparison of human papillomavirus DNA prevalence in atypical squamous cells of undetermined significance subcategories as defined by the original Bethesda 1991 and the new Bethesda 2001 Systems. Archives Of Pathology & Laboratory Medicine 2004, 128: 527-32. PMID: 15086283, DOI: 10.5858/2004-128-527-COHPDP.
- Harigopal M, Sahoo S, Recant WM, DeMay RM. Fine-needle aspiration of Riedel's disease: report of a case and review of the literature. Diagnostic Cytopathology 2004, 30: 193-7. PMID: 14986301, DOI: 10.1002/dc.10420.
- Harigopal M, Park K, Chen X, Rosen PP. Pathologic quiz case: a rapidly increasing breast mass in a postmenopausal woman. Malignant adenomyoepithelioma. Archives Of Pathology & Laboratory Medicine 2004, 128: 235-6. PMID: 14736274, DOI: 10.5858/2004-128-235-PQCARI.
- Harigopal M, Hoda SA, Seshan SV. Images in pathology: congo-red negative fibrillary glomerulonephritis. International Journal Of Surgical Pathology 2003, 11: 313. PMID: 14615827, DOI: 10.1177/106689690301100409.
- Harigopal M, Hoda SA. Images in pathology: inclusion bodies in phyllodes tumor of breast. International Journal Of Surgical Pathology 2003, 11: 220. PMID: 12894356, DOI: 10.1177/106689690301100311.
- Harigopal M, Mudrovich SA, Hoda SA, Rosen PP. Secondary tumors in mammary adenolipomas: a report of 2 unusual cases. Archives Of Pathology & Laboratory Medicine 2003, 127: e151-4. PMID: 12653605, DOI: 10.5858/2003-127-e151-STIMAA.
- Yao DX, Hoda SA, Yin DY, Kuhel WI, Harigopal M, Resetkova E, DeLellis RA. Interpretative problems and preparative technique influence reliability of intraoperative parathyroid touch imprints. Archives Of Pathology & Laboratory Medicine 2003, 127: 64-7. PMID: 12521369, DOI: 10.5858/2003-127-64-IPAPTI.
- Hoda SA, Chiu A, Resetkova E, Harigopal M, Hoda RS, Osborne MP. Pathological examination of sentinel lymph node in breast cancer: potential problems and possible solutions. Microscopy Research And Technique 2002, 59: 85-91. PMID: 12373718, DOI: 10.1002/jemt.10179.
- Harigopal M, Seshan SV, DeLellis RA, Yankelevitz D, Vazquez M. Aspiration cytology of elastofibroma dorsi: case report with ultrastructural and immunohistochemical findings. Diagnostic Cytopathology 2002, 26: 310-3. PMID: 11992374, DOI: 10.1002/dc.10106.