- Smilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
- Smilow Cancer Hospital Melanoma ProgramYale New Haven Shoreline Medical Center111 Goose LaneGuilford, CT 06437
Kelly Olino, MD, FACS
Biography
Kelly Olino, MD, is a surgical oncologist with additional training in cancer immunotherapy. She treats skin cancer in patients who range from teenagers to people in their 90s. “I see a wide variety of people, because skin cancer affects everybody, unfortunately,” she says.
As a surgeon, Dr. Olino cares for patients in the office and in the operating room, removing skin and soft tissue tumors that occur anywhere on the body, and performing minimally invasive surgeries to treat metastatic skin cancer when it spreads to internal organs. “When I am treating a patient with skin cancer, I think not only about the technical expertise required to perform a given surgery, but more importantly how the surgery fits into the scope of a larger plan for that patient,” says Dr. Olino, who has additional training in immunotherapy, which she describes as a “revolutionary” step in the treatment of skin cancer. Skin cancer specialists were among the first doctors to successfully use immunotherapy, which harnesses the body’s own immune system to target cancer.
Dr. Olino decided to become a surgical oncologist partly because the patients she met as a trainee were so appreciative. She, in turn, has always taken the time to make sure each patient fully understands his or her condition and treatment. “Patients should know what's going on. Their families should know. I joke with them all the time. I say to them, "You know, I'm bilingual. I speak “Doctor” and I speak English, so please let me know if I start to speak “Doctor,” because if you don’t understand what I’m doing and why, it's time for me to explain it again.”
As an assistant professor of surgery at Yale School of Medicine, Dr. Olino focuses her research on immunotherapy for skin cancer. She is currently part of a team that is looking at novel ways to combine different types of immunotherapies and move those therapies from the laboratory to patient care clinics.
Titles
- Assistant Professor of Surgery (Oncology)
- Leader, Skin Cancer Surgery, Melanoma Program
- Clinical Director of the Smilow Melanoma Program, Yale Cancer Center
Education & Training
- FellowshipThe Memorial Sloan Kettering Cancer Center (2015)
- ResidencyThe Johns Hopkins Hospital (2013)
- MDThe Johns Hopkins School of Medicine (2005)
- BSCornell University, Biological Sciences-Neurobiology (2000)
Additional Information
- AB of Surgery, Complex General Surgical Oncology (2016)
- AB of Surgery, Surgery, General (2013)
- Yale Department of Surgery Compensation Committee (2022 - Present): Member
- The Society of Surgical Oncology (2022 - Present): Scientific Program Committee- Chair Immuno-oncology subgroup
- Status of Women in Medicine- Department of Surgery Liason (2022 - Present): Liaison
- National Comprehensive Cancer Network- Non-Melanoma Skin Cancer Guideline Panel (2022 - Present): Creation of national guidelines for merkel cell carcinoma, cutaneous squamous cell carcinoma, basal cell carcinoma and dermatofibrosarcoma protuberans
- Yale New Haven Hospital Credentials Committee (2021 - Present): Member
- Yale Cancer Center - Smilow Clinical Council (2021 - Present): Member
- Schwartz Cancer Center Grand Rounds Planning Committee (2021 - Present): Committee Member
- The Society of Surgical Oncology (2020 - 2022): Melanoma Disease Site Working Group. Planning of education activities and guidelines for the management of cutaneous malignancies.
- Yale Center for Immuno-Oncology (2019 - Present): Symposia and seminar planning committee
- Association for Academic Surgery (2016 - Present): Program Committee
- Farshidfar F, Rhrissorrakrai K, Levovitz C, Peng C, Knight J, Bacchiocchi A, Su J, Yin M, Sznol M, Ariyan S, Clune J, Olino K, Parida L, Nikolaus J, Zhang M, Zhao S, Wang Y, Huang G, Wan M, Li X, Cao J, Yan Q, Chen X, Newman AM, Halaban R. Author Correction: Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis. Nature Communications 2022, 13: 2704. PMID: 35538087, PMCID: PMC9090916, DOI: 10.1038/s41467-022-30446-w.
- Farshidfar F, Rhrissorrakrai K, Levovitz C, Peng C, Knight J, Bacchiocchi A, Su J, Yin M, Sznol M, Ariyan S, Clune J, Olino K, Parida L, Nikolaus J, Zhang M, Zhao S, Wang Y, Huang G, Wan M, Li X, Cao J, Yan Q, Chen X, Newman AM, Halaban R. Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis. Nature Communications 2022, 13: 898. PMID: 35197475, PMCID: PMC8866401, DOI: 10.1038/s41467-022-28566-4.
- Esposito A, Jacobs D, Ariyan S, Galan A, Kluger H, Clune J, Weiss S, Tran T, Olino K. Merkel Cell Carcinoma: Changing Practice Patterns and Impact on Recurrence-Free and Overall Survival at a Single Institution and Nationally. Annals Of Surgical Oncology 2022, 29: 415-424. PMID: 34494169, PMCID: PMC8677689, DOI: 10.1245/s10434-021-10727-2.
- Esposito AC, Jacobs D, Olino K. ASO Author Reflections: The Utility of Overall Survival as an Outcome in the Study of Merkel Cell Carcinoma. Annals Of Surgical Oncology 2022, 29: 425-426. PMID: 34523003, DOI: 10.1245/s10434-021-10791-8.
- Xie CB, Ring N, Damsky W, McNiff JM, Olino K, Odell I. Squamous cell carcinoma arising in long-standing necrobiosis lipoidica treated with radical resection and split-thickness skin graft. JAAD Case Reports 2022, 19: 90-93. PMID: 35024397, PMCID: PMC8724883, DOI: 10.1016/j.jdcr.2021.11.005.
- Esposito A, Jacobs D, Ariyan S, Galan A, Kluger H, Clune J, Weiss S, Tran T, Olino K. ASO Visual Abstract: Merkel Cell Carcinoma-Changing Practice Patterns and Impact on Recurrence-Free and Overall Survival at a Single Institution and Nationally. Annals Of Surgical Oncology 2021, 28: 736-737. PMID: 34564774, DOI: 10.1245/s10434-021-10784-7.
- Noorbakhsh S, Papageorge M, Maina RM, Baumann R, Moores C, Weiss SA, Pucar D, Ariyan S, Olino K, Clune J. Methods of Sentinel Lymph Node Identification in Auricular Melanoma. Plastic And Reconstructive Surgery. Global Open 2021, 9: e4004. PMID: 34938645, PMCID: PMC8687720, DOI: 10.1097/GOX.0000000000004004.
- Hasan NM, Sharma A, Ruzgar NM, Deshpande H, Olino K, Khan S, Ahuja N. Epigenetic signatures differentiate uterine and soft tissue leiomyosarcoma. Oncotarget 2021, 12: 1566-1579. PMID: 34381562, PMCID: PMC8351604, DOI: 10.18632/oncotarget.28032.
- Primary Treatment Selection for Clinically Node-Negative Merkel Cell Carcinoma of the Head and Neck.Jacobs D, Olino K, Park HS, Clune J, Cheraghlou S, Girardi M, Burtness B, Kluger H, Judson BL. Primary Treatment Selection for Clinically Node-Negative Merkel Cell Carcinoma of the Head and Neck. Otolaryngology--head And Neck Surgery : Official Journal Of American Academy Of Otolaryngology-Head And Neck Surgery 2021, 164: 1214-1221. PMID: 33079010, DOI: 10.1177/0194599820967001.
- Lucca LE, Axisa PP, Lu B, Harnett B, Jessel S, Zhang L, Raddassi K, Zhang L, Olino K, Clune J, Singer M, Kluger HM, Hafler DA. Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells. The Journal Of Experimental Medicine 2021, 218 PMID: 33651881, PMCID: PMC7933991, DOI: 10.1084/jem.20200921.
- Talty R, Olino K. Metabolism of Innate Immune Cells in Cancer. Cancers 2021, 13 PMID: 33670082, PMCID: PMC7927092, DOI: 10.3390/cancers13040904.
- Jacobs D, Huang H, Olino K, Weiss S, Kluger H, Judson BL, Zhang Y. Assessment of Age, Period, and Birth Cohort Effects and Trends in Merkel Cell Carcinoma Incidence in the United States. JAMA Dermatology 2021, 157: 59-65. PMID: 33146688, PMCID: PMC7643047, DOI: 10.1001/jamadermatol.2020.4102.
- Olino K, Park T, Ahuja N. Exposing Hidden Targets: Combining epigenetic and immunotherapy to overcome cancer resistance. Seminars In Cancer Biology 2020, 65: 114-122. PMID: 31911188, DOI: 10.1016/j.semcancer.2020.01.001.
- Ligtenberg KG, Hu JK, Damsky W, Olino K, Kluger H, Clune J, Cowper SE, Panse G, Leventhal J, Weiss SA. Neoadjuvant anti-programmed cell death 1 therapy for locally advanced basal cell carcinoma in treatment-naive patients: A case series. JAAD Case Reports 2020, 6: 628-633. PMID: 32613057, PMCID: PMC7317689, DOI: 10.1016/j.jdcr.2020.05.010.
- Klemen ND, Wang M, Rubinstein JC, Olino K, Clune J, Ariyan S, Cha C, Weiss SA, Kluger HM, Sznol M. Survival after checkpoint inhibitors for metastatic acral, mucosal and uveal melanoma. Journal For Immunotherapy Of Cancer 2020, 8 PMID: 32209601, PMCID: PMC7103823, DOI: 10.1136/jitc-2019-000341.
- Raj N, Zheng Y, Kelly V, Katz SS, Chou J, Do RKG, Capanu M, Zamarin D, Saltz LB, Ariyan CE, Untch BR, O'Reilly EM, Gopalan A, Berger MF, Olino K, Segal NH, Reidy-Lagunes DL. PD-1 Blockade in Advanced Adrenocortical Carcinoma. Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology 2020, 38: 71-80. PMID: 31644329, PMCID: PMC7351334, DOI: 10.1200/JCO.19.01586.
- Klemen ND, Wang M, Feingold PL, Cooper K, Pavri SN, Han D, Detterbeck FC, Boffa DJ, Khan SA, Olino K, Clune J, Ariyan S, Salem RR, Weiss SA, Kluger HM, Sznol M, Cha C. Patterns of failure after immunotherapy with checkpoint inhibitors predict durable progression-free survival after local therapy for metastatic melanoma. Journal For Immunotherapy Of Cancer 2019, 7: 196. PMID: 31340861, PMCID: PMC6657062, DOI: 10.1186/s40425-019-0672-3.
- McAuliffe JC, Tang LH, Kamrani K, Olino K, Klimstra DS, Brennan MF, Coit DG. Prevalence of False-Negative Results of Intraoperative Consultation on Surgical Margins During Resection of Gastric and Gastroesophageal Adenocarcinoma. JAMA Surgery 2019, 154: 126-132. PMID: 30422226, PMCID: PMC6439656, DOI: 10.1001/jamasurg.2018.3863.
- Zhao J, Olino K, Low LE, Qiu S, Stevenson HL. Hepatic Inflammatory Pseudotumor: An Important Differential Diagnosis in Patients With a History of Previous Biliary Procedures. ACG Case Reports Journal 2019, 6: e00015. PMID: 31598534, PMCID: PMC6657982, DOI: 10.14309/crj.0000000000000015.
- Olino KL, Tyler DS. Gastric Neoplasms. The Surgical Clinics Of North America 2017, 97: xv-xvi. PMID: 28325200, DOI: 10.1016/j.suc.2017.02.001.
- Perone JA, Riall TS, Olino K. Palliative Care for Pancreatic and Periampullary Cancer. The Surgical Clinics Of North America 2016, 96: 1415-1430. PMID: 27865285, PMCID: PMC5119929, DOI: 10.1016/j.suc.2016.07.012.
- Olino K, Tyler DS. What is the OPTiMal Way to Manage In-Transit Disease? Annals Of Surgical Oncology 2016, 23: 4126-4129. PMID: 27380046, DOI: 10.1245/s10434-016-5393-y.
- Dimou FM, Adhikari D, Mehta HB, Olino K, Riall TS, Brown KM. Incidence of hepaticojejunostomy stricture after hepaticojejunostomy. Surgery 2016, 160: 691-8. PMID: 27392391, PMCID: PMC5429863, DOI: 10.1016/j.surg.2016.05.021.
- Faisal F, Tsai HL, Blackford A, Olino K, Xia C, De Jesus-Acosta A, Le DT, Cosgrove D, Azad N, Rasheed Z, Diaz LA, Donehower R, Laheru D, Hruban RH, Fishman EK, Edil BH, Schulick R, Wolfgang C, Herman J, Zheng L. Longer Course of Induction Chemotherapy Followed by Chemoradiation Favors Better Survival Outcomes for Patients With Locally Advanced Pancreatic Cancer. American Journal Of Clinical Oncology 2016, 39: 18-26. PMID: 24351782, PMCID: PMC4061284, DOI: 10.1097/COC.0000000000000022.
- Soares KC, Rucki AA, Wu AA, Olino K, Xiao Q, Chai Y, Wamwea A, Bigelow E, Lutz E, Liu L, Yao S, Anders RA, Laheru D, Wolfgang CL, Edil BH, Schulick RD, Jaffee EM, Zheng L. PD-1/PD-L1 blockade together with vaccine therapy facilitates effector T-cell infiltration into pancreatic tumors. Journal Of Immunotherapy (Hagerstown, Md. : 1997) 2015, 38: 1-11. PMID: 25415283, PMCID: PMC4258151, DOI: 10.1097/CJI.0000000000000062.
- Ellison TA, Wolfgang CL, Shi C, Cameron JL, Murakami P, Mun LJ, Singhi AD, Cornish TC, Olino K, Meriden Z, Choti M, Diaz LA, Pawlik TM, Schulick RD, Hruban RH, Edil BH. A single institution's 26-year experience with nonfunctional pancreatic neuroendocrine tumors: a validation of current staging systems and a new prognostic nomogram. Annals Of Surgery 2014, 259: 204-12. PMID: 23673766, PMCID: PMC4048026, DOI: 10.1097/SLA.0b013e31828f3174.
- Olino K, Wada S, Edil BH, Pan X, Meckel K, Weber W, Slansky J, Tamada K, Lauer P, Brockstedt D, Pardoll D, Schulick R, Yoshimura K. Tumor-associated antigen expressing Listeria monocytogenes induces effective primary and memory T-cell responses against hepatic colorectal cancer metastases. Annals Of Surgical Oncology 2012, 19 Suppl 3: S597-607. PMID: 21979110, PMCID: PMC4498288, DOI: 10.1245/s10434-011-2037-0.
- Mayo SC, Nathan H, Cameron JL, Olino K, Edil BH, Herman JM, Hirose K, Schulick RD, Choti MA, Wolfgang CL, Pawlik TM. Conditional survival in patients with pancreatic ductal adenocarcinoma resected with curative intent. Cancer 2012, 118: 2674-81. PMID: 21935914, PMCID: PMC3578343, DOI: 10.1002/cncr.26553.
- Olino K, Edil BH, Meckel KF, Pan X, Thuluvath A, Pardoll DM, Schulick RD, Yoshimura K, Weber WP. Glycolipid antigens for treating hepatic colorectal cancer metastases and their effect on the therapeutic efficacy of live attenuated Listeria monocytogenes. Archives Of Surgery (Chicago, Ill. : 1960) 2012, 147: 480-2. PMID: 22785644, PMCID: PMC4144826, DOI: 10.1001/archsurg.2011.2206.
- Matthaei H, Norris AL, Tsiatis AC, Olino K, Hong SM, dal Molin M, Goggins MG, Canto M, Horton KM, Jackson KD, Capelli P, Zamboni G, Bortesi L, Furukawa T, Egawa S, Ishida M, Ottomo S, Unno M, Motoi F, Wolfgang CL, Edil BH, Cameron JL, Eshleman JR, Schulick RD, Maitra A, Hruban RH. Clinicopathological characteristics and molecular analyses of multifocal intraductal papillary mucinous neoplasms of the pancreas. Annals Of Surgery 2012, 255: 326-33. PMID: 22167000, PMCID: PMC3534752, DOI: 10.1097/SLA.0b013e3182378a18.
- Matthaei H, Hong SM, Mayo SC, dal Molin M, Olino K, Venkat R, Goggins M, Herman JM, Edil BH, Wolfgang CL, Cameron JL, Schulick RD, Maitra A, Hruban RH. Presence of pancreatic intraepithelial neoplasia in the pancreatic transection margin does not influence outcome in patients with R0 resected pancreatic cancer. Annals Of Surgical Oncology 2011, 18: 3493-9. PMID: 21537863, PMCID: PMC3166423, DOI: 10.1245/s10434-011-1745-9.
- Loss of E-cadherin expression and outcome among patients with resectable pancreatic adenocarcinomas.Hong SM, Li A, Olino K, Wolfgang CL, Herman JM, Schulick RD, Iacobuzio-Donahue C, Hruban RH, Goggins M. Loss of E-cadherin expression and outcome among patients with resectable pancreatic adenocarcinomas. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2011, 24: 1237-47. PMID: 21552209, PMCID: PMC3155013, DOI: 10.1038/modpathol.2011.74.
- Zheng L, Foley K, Huang L, Leubner A, Mo G, Olino K, Edil BH, Mizuma M, Sharma R, Le DT, Anders RA, Illei PB, Van Eyk JE, Maitra A, Laheru D, Jaffee EM. Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer. PloS One 2011, 6: e19390. PMID: 21572519, PMCID: PMC3084841, DOI: 10.1371/journal.pone.0019390.
- Matthaei H, Hong SM, Mayo SC, Dal Molin M, Olino K, Venkat R, Goggins M, Herman JM, Edil BH, Wolfgang CL, Cameron JL, Schulick RD, Maitra A, Hruban RH. Presence of pancreatic intraepithelial neoplasia in the pancreatic transection margin does not influence outcome in patients with R0 resected pancreatic cancer. Indian Journal Of Surgical Oncology 2011, 2: 9-15. PMID: 22696140, PMCID: PMC3373004, DOI: 10.1007/s13193-011-0073-7.
- Yoshimura K, Olino K, Edil BH, Schulick RD, Oka M. Immuno- and gene-therapeutic strategies targeted against cancer (mainly focusing on pancreatic cancer). Surgery Today 2010, 40: 404-10. PMID: 20425541, DOI: 10.1007/s00595-009-4120-8.
- Winter JM, Cameron JL, Olino K, Herman JM, de Jong MC, Hruban RH, Wolfgang CL, Eckhauser F, Edil BH, Choti MA, Schulick RD, Pawlik TM. Clinicopathologic analysis of ampullary neoplasms in 450 patients: implications for surgical strategy and long-term prognosis. Journal Of Gastrointestinal Surgery : Official Journal Of The Society For Surgery Of The Alimentary Tract 2010, 14: 379-87. PMID: 19911239, DOI: 10.1007/s11605-009-1080-7.
- Yoshimura K, Meckel KF, Laird LS, Chia CY, Park JJ, Olino KL, Tsunedomi R, Harada T, Iizuka N, Hazama S, Kato Y, Keller JW, Thompson JM, Chang F, Romer LH, Jain A, Iacobuzio-Donahue C, Oka M, Pardoll DM, Schulick RD. Integrin alpha2 mediates selective metastasis to the liver. Cancer Research 2009, 69: 7320-8. PMID: 19738067, PMCID: PMC4857201, DOI: 10.1158/0008-5472.CAN-09-0315.
- Blackford A, Serrano OK, Wolfgang CL, Parmigiani G, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Cameron JL, Olino K, Schulick R, Winter J, Herman JM, Laheru D, Klein AP, Vogelstein B, Kinzler KW, Velculescu VE, Hruban RH. SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2009, 15: 4674-9. PMID: 19584151, PMCID: PMC2819274, DOI: 10.1158/1078-0432.CCR-09-0227.
- Blackford A, Parmigiani G, Kensler TW, Wolfgang C, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Klein A, Cameron JL, Olino K, Schulick R, Winter J, Vogelstein B, Velculescu VE, Kinzler KW, Hruban RH. Genetic mutations associated with cigarette smoking in pancreatic cancer. Cancer Research 2009, 69: 3681-8. PMID: 19351817, PMCID: PMC2669837, DOI: 10.1158/0008-5472.CAN-09-0015.
- Melanoma Program
- Surgery
- Surgical Oncology
- Yale Cancer Center
- Smilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
- Smilow Cancer Hospital Melanoma ProgramYale New Haven Shoreline Medical Center111 Goose LaneGuilford, CT 06437
Biography
Kelly Olino, MD, is a surgical oncologist with additional training in cancer immunotherapy. She treats skin cancer in patients who range from teenagers to people in their 90s. “I see a wide variety of people, because skin cancer affects everybody, unfortunately,” she says.
As a surgeon, Dr. Olino cares for patients in the office and in the operating room, removing skin and soft tissue tumors that occur anywhere on the body, and performing minimally invasive surgeries to treat metastatic skin cancer when it spreads to internal organs. “When I am treating a patient with skin cancer, I think not only about the technical expertise required to perform a given surgery, but more importantly how the surgery fits into the scope of a larger plan for that patient,” says Dr. Olino, who has additional training in immunotherapy, which she describes as a “revolutionary” step in the treatment of skin cancer. Skin cancer specialists were among the first doctors to successfully use immunotherapy, which harnesses the body’s own immune system to target cancer.
Dr. Olino decided to become a surgical oncologist partly because the patients she met as a trainee were so appreciative. She, in turn, has always taken the time to make sure each patient fully understands his or her condition and treatment. “Patients should know what's going on. Their families should know. I joke with them all the time. I say to them, "You know, I'm bilingual. I speak “Doctor” and I speak English, so please let me know if I start to speak “Doctor,” because if you don’t understand what I’m doing and why, it's time for me to explain it again.”
As an assistant professor of surgery at Yale School of Medicine, Dr. Olino focuses her research on immunotherapy for skin cancer. She is currently part of a team that is looking at novel ways to combine different types of immunotherapies and move those therapies from the laboratory to patient care clinics.
Titles
- Assistant Professor of Surgery (Oncology)
- Leader, Skin Cancer Surgery, Melanoma Program
- Clinical Director of the Smilow Melanoma Program, Yale Cancer Center
Education & Training
- FellowshipThe Memorial Sloan Kettering Cancer Center (2015)
- ResidencyThe Johns Hopkins Hospital (2013)
- MDThe Johns Hopkins School of Medicine (2005)
- BSCornell University, Biological Sciences-Neurobiology (2000)
Additional Information
- AB of Surgery, Complex General Surgical Oncology (2016)
- AB of Surgery, Surgery, General (2013)
- Yale Department of Surgery Compensation Committee (2022 - Present): Member
- The Society of Surgical Oncology (2022 - Present): Scientific Program Committee- Chair Immuno-oncology subgroup
- Status of Women in Medicine- Department of Surgery Liason (2022 - Present): Liaison
- National Comprehensive Cancer Network- Non-Melanoma Skin Cancer Guideline Panel (2022 - Present): Creation of national guidelines for merkel cell carcinoma, cutaneous squamous cell carcinoma, basal cell carcinoma and dermatofibrosarcoma protuberans
- Yale New Haven Hospital Credentials Committee (2021 - Present): Member
- Yale Cancer Center - Smilow Clinical Council (2021 - Present): Member
- Schwartz Cancer Center Grand Rounds Planning Committee (2021 - Present): Committee Member
- The Society of Surgical Oncology (2020 - 2022): Melanoma Disease Site Working Group. Planning of education activities and guidelines for the management of cutaneous malignancies.
- Yale Center for Immuno-Oncology (2019 - Present): Symposia and seminar planning committee
- Association for Academic Surgery (2016 - Present): Program Committee
- Farshidfar F, Rhrissorrakrai K, Levovitz C, Peng C, Knight J, Bacchiocchi A, Su J, Yin M, Sznol M, Ariyan S, Clune J, Olino K, Parida L, Nikolaus J, Zhang M, Zhao S, Wang Y, Huang G, Wan M, Li X, Cao J, Yan Q, Chen X, Newman AM, Halaban R. Author Correction: Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis. Nature Communications 2022, 13: 2704. PMID: 35538087, PMCID: PMC9090916, DOI: 10.1038/s41467-022-30446-w.
- Farshidfar F, Rhrissorrakrai K, Levovitz C, Peng C, Knight J, Bacchiocchi A, Su J, Yin M, Sznol M, Ariyan S, Clune J, Olino K, Parida L, Nikolaus J, Zhang M, Zhao S, Wang Y, Huang G, Wan M, Li X, Cao J, Yan Q, Chen X, Newman AM, Halaban R. Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis. Nature Communications 2022, 13: 898. PMID: 35197475, PMCID: PMC8866401, DOI: 10.1038/s41467-022-28566-4.
- Esposito A, Jacobs D, Ariyan S, Galan A, Kluger H, Clune J, Weiss S, Tran T, Olino K. Merkel Cell Carcinoma: Changing Practice Patterns and Impact on Recurrence-Free and Overall Survival at a Single Institution and Nationally. Annals Of Surgical Oncology 2022, 29: 415-424. PMID: 34494169, PMCID: PMC8677689, DOI: 10.1245/s10434-021-10727-2.
- Esposito AC, Jacobs D, Olino K. ASO Author Reflections: The Utility of Overall Survival as an Outcome in the Study of Merkel Cell Carcinoma. Annals Of Surgical Oncology 2022, 29: 425-426. PMID: 34523003, DOI: 10.1245/s10434-021-10791-8.
- Xie CB, Ring N, Damsky W, McNiff JM, Olino K, Odell I. Squamous cell carcinoma arising in long-standing necrobiosis lipoidica treated with radical resection and split-thickness skin graft. JAAD Case Reports 2022, 19: 90-93. PMID: 35024397, PMCID: PMC8724883, DOI: 10.1016/j.jdcr.2021.11.005.
- Esposito A, Jacobs D, Ariyan S, Galan A, Kluger H, Clune J, Weiss S, Tran T, Olino K. ASO Visual Abstract: Merkel Cell Carcinoma-Changing Practice Patterns and Impact on Recurrence-Free and Overall Survival at a Single Institution and Nationally. Annals Of Surgical Oncology 2021, 28: 736-737. PMID: 34564774, DOI: 10.1245/s10434-021-10784-7.
- Noorbakhsh S, Papageorge M, Maina RM, Baumann R, Moores C, Weiss SA, Pucar D, Ariyan S, Olino K, Clune J. Methods of Sentinel Lymph Node Identification in Auricular Melanoma. Plastic And Reconstructive Surgery. Global Open 2021, 9: e4004. PMID: 34938645, PMCID: PMC8687720, DOI: 10.1097/GOX.0000000000004004.
- Hasan NM, Sharma A, Ruzgar NM, Deshpande H, Olino K, Khan S, Ahuja N. Epigenetic signatures differentiate uterine and soft tissue leiomyosarcoma. Oncotarget 2021, 12: 1566-1579. PMID: 34381562, PMCID: PMC8351604, DOI: 10.18632/oncotarget.28032.
- Primary Treatment Selection for Clinically Node-Negative Merkel Cell Carcinoma of the Head and Neck.Jacobs D, Olino K, Park HS, Clune J, Cheraghlou S, Girardi M, Burtness B, Kluger H, Judson BL. Primary Treatment Selection for Clinically Node-Negative Merkel Cell Carcinoma of the Head and Neck. Otolaryngology--head And Neck Surgery : Official Journal Of American Academy Of Otolaryngology-Head And Neck Surgery 2021, 164: 1214-1221. PMID: 33079010, DOI: 10.1177/0194599820967001.
- Lucca LE, Axisa PP, Lu B, Harnett B, Jessel S, Zhang L, Raddassi K, Zhang L, Olino K, Clune J, Singer M, Kluger HM, Hafler DA. Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells. The Journal Of Experimental Medicine 2021, 218 PMID: 33651881, PMCID: PMC7933991, DOI: 10.1084/jem.20200921.
- Talty R, Olino K. Metabolism of Innate Immune Cells in Cancer. Cancers 2021, 13 PMID: 33670082, PMCID: PMC7927092, DOI: 10.3390/cancers13040904.
- Jacobs D, Huang H, Olino K, Weiss S, Kluger H, Judson BL, Zhang Y. Assessment of Age, Period, and Birth Cohort Effects and Trends in Merkel Cell Carcinoma Incidence in the United States. JAMA Dermatology 2021, 157: 59-65. PMID: 33146688, PMCID: PMC7643047, DOI: 10.1001/jamadermatol.2020.4102.
- Olino K, Park T, Ahuja N. Exposing Hidden Targets: Combining epigenetic and immunotherapy to overcome cancer resistance. Seminars In Cancer Biology 2020, 65: 114-122. PMID: 31911188, DOI: 10.1016/j.semcancer.2020.01.001.
- Ligtenberg KG, Hu JK, Damsky W, Olino K, Kluger H, Clune J, Cowper SE, Panse G, Leventhal J, Weiss SA. Neoadjuvant anti-programmed cell death 1 therapy for locally advanced basal cell carcinoma in treatment-naive patients: A case series. JAAD Case Reports 2020, 6: 628-633. PMID: 32613057, PMCID: PMC7317689, DOI: 10.1016/j.jdcr.2020.05.010.
- Klemen ND, Wang M, Rubinstein JC, Olino K, Clune J, Ariyan S, Cha C, Weiss SA, Kluger HM, Sznol M. Survival after checkpoint inhibitors for metastatic acral, mucosal and uveal melanoma. Journal For Immunotherapy Of Cancer 2020, 8 PMID: 32209601, PMCID: PMC7103823, DOI: 10.1136/jitc-2019-000341.
- Raj N, Zheng Y, Kelly V, Katz SS, Chou J, Do RKG, Capanu M, Zamarin D, Saltz LB, Ariyan CE, Untch BR, O'Reilly EM, Gopalan A, Berger MF, Olino K, Segal NH, Reidy-Lagunes DL. PD-1 Blockade in Advanced Adrenocortical Carcinoma. Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology 2020, 38: 71-80. PMID: 31644329, PMCID: PMC7351334, DOI: 10.1200/JCO.19.01586.
- Klemen ND, Wang M, Feingold PL, Cooper K, Pavri SN, Han D, Detterbeck FC, Boffa DJ, Khan SA, Olino K, Clune J, Ariyan S, Salem RR, Weiss SA, Kluger HM, Sznol M, Cha C. Patterns of failure after immunotherapy with checkpoint inhibitors predict durable progression-free survival after local therapy for metastatic melanoma. Journal For Immunotherapy Of Cancer 2019, 7: 196. PMID: 31340861, PMCID: PMC6657062, DOI: 10.1186/s40425-019-0672-3.
- McAuliffe JC, Tang LH, Kamrani K, Olino K, Klimstra DS, Brennan MF, Coit DG. Prevalence of False-Negative Results of Intraoperative Consultation on Surgical Margins During Resection of Gastric and Gastroesophageal Adenocarcinoma. JAMA Surgery 2019, 154: 126-132. PMID: 30422226, PMCID: PMC6439656, DOI: 10.1001/jamasurg.2018.3863.
- Zhao J, Olino K, Low LE, Qiu S, Stevenson HL. Hepatic Inflammatory Pseudotumor: An Important Differential Diagnosis in Patients With a History of Previous Biliary Procedures. ACG Case Reports Journal 2019, 6: e00015. PMID: 31598534, PMCID: PMC6657982, DOI: 10.14309/crj.0000000000000015.
- Olino KL, Tyler DS. Gastric Neoplasms. The Surgical Clinics Of North America 2017, 97: xv-xvi. PMID: 28325200, DOI: 10.1016/j.suc.2017.02.001.
- Perone JA, Riall TS, Olino K. Palliative Care for Pancreatic and Periampullary Cancer. The Surgical Clinics Of North America 2016, 96: 1415-1430. PMID: 27865285, PMCID: PMC5119929, DOI: 10.1016/j.suc.2016.07.012.
- Olino K, Tyler DS. What is the OPTiMal Way to Manage In-Transit Disease? Annals Of Surgical Oncology 2016, 23: 4126-4129. PMID: 27380046, DOI: 10.1245/s10434-016-5393-y.
- Dimou FM, Adhikari D, Mehta HB, Olino K, Riall TS, Brown KM. Incidence of hepaticojejunostomy stricture after hepaticojejunostomy. Surgery 2016, 160: 691-8. PMID: 27392391, PMCID: PMC5429863, DOI: 10.1016/j.surg.2016.05.021.
- Faisal F, Tsai HL, Blackford A, Olino K, Xia C, De Jesus-Acosta A, Le DT, Cosgrove D, Azad N, Rasheed Z, Diaz LA, Donehower R, Laheru D, Hruban RH, Fishman EK, Edil BH, Schulick R, Wolfgang C, Herman J, Zheng L. Longer Course of Induction Chemotherapy Followed by Chemoradiation Favors Better Survival Outcomes for Patients With Locally Advanced Pancreatic Cancer. American Journal Of Clinical Oncology 2016, 39: 18-26. PMID: 24351782, PMCID: PMC4061284, DOI: 10.1097/COC.0000000000000022.
- Soares KC, Rucki AA, Wu AA, Olino K, Xiao Q, Chai Y, Wamwea A, Bigelow E, Lutz E, Liu L, Yao S, Anders RA, Laheru D, Wolfgang CL, Edil BH, Schulick RD, Jaffee EM, Zheng L. PD-1/PD-L1 blockade together with vaccine therapy facilitates effector T-cell infiltration into pancreatic tumors. Journal Of Immunotherapy (Hagerstown, Md. : 1997) 2015, 38: 1-11. PMID: 25415283, PMCID: PMC4258151, DOI: 10.1097/CJI.0000000000000062.
- Ellison TA, Wolfgang CL, Shi C, Cameron JL, Murakami P, Mun LJ, Singhi AD, Cornish TC, Olino K, Meriden Z, Choti M, Diaz LA, Pawlik TM, Schulick RD, Hruban RH, Edil BH. A single institution's 26-year experience with nonfunctional pancreatic neuroendocrine tumors: a validation of current staging systems and a new prognostic nomogram. Annals Of Surgery 2014, 259: 204-12. PMID: 23673766, PMCID: PMC4048026, DOI: 10.1097/SLA.0b013e31828f3174.
- Olino K, Wada S, Edil BH, Pan X, Meckel K, Weber W, Slansky J, Tamada K, Lauer P, Brockstedt D, Pardoll D, Schulick R, Yoshimura K. Tumor-associated antigen expressing Listeria monocytogenes induces effective primary and memory T-cell responses against hepatic colorectal cancer metastases. Annals Of Surgical Oncology 2012, 19 Suppl 3: S597-607. PMID: 21979110, PMCID: PMC4498288, DOI: 10.1245/s10434-011-2037-0.
- Mayo SC, Nathan H, Cameron JL, Olino K, Edil BH, Herman JM, Hirose K, Schulick RD, Choti MA, Wolfgang CL, Pawlik TM. Conditional survival in patients with pancreatic ductal adenocarcinoma resected with curative intent. Cancer 2012, 118: 2674-81. PMID: 21935914, PMCID: PMC3578343, DOI: 10.1002/cncr.26553.
- Olino K, Edil BH, Meckel KF, Pan X, Thuluvath A, Pardoll DM, Schulick RD, Yoshimura K, Weber WP. Glycolipid antigens for treating hepatic colorectal cancer metastases and their effect on the therapeutic efficacy of live attenuated Listeria monocytogenes. Archives Of Surgery (Chicago, Ill. : 1960) 2012, 147: 480-2. PMID: 22785644, PMCID: PMC4144826, DOI: 10.1001/archsurg.2011.2206.
- Matthaei H, Norris AL, Tsiatis AC, Olino K, Hong SM, dal Molin M, Goggins MG, Canto M, Horton KM, Jackson KD, Capelli P, Zamboni G, Bortesi L, Furukawa T, Egawa S, Ishida M, Ottomo S, Unno M, Motoi F, Wolfgang CL, Edil BH, Cameron JL, Eshleman JR, Schulick RD, Maitra A, Hruban RH. Clinicopathological characteristics and molecular analyses of multifocal intraductal papillary mucinous neoplasms of the pancreas. Annals Of Surgery 2012, 255: 326-33. PMID: 22167000, PMCID: PMC3534752, DOI: 10.1097/SLA.0b013e3182378a18.
- Matthaei H, Hong SM, Mayo SC, dal Molin M, Olino K, Venkat R, Goggins M, Herman JM, Edil BH, Wolfgang CL, Cameron JL, Schulick RD, Maitra A, Hruban RH. Presence of pancreatic intraepithelial neoplasia in the pancreatic transection margin does not influence outcome in patients with R0 resected pancreatic cancer. Annals Of Surgical Oncology 2011, 18: 3493-9. PMID: 21537863, PMCID: PMC3166423, DOI: 10.1245/s10434-011-1745-9.
- Loss of E-cadherin expression and outcome among patients with resectable pancreatic adenocarcinomas.Hong SM, Li A, Olino K, Wolfgang CL, Herman JM, Schulick RD, Iacobuzio-Donahue C, Hruban RH, Goggins M. Loss of E-cadherin expression and outcome among patients with resectable pancreatic adenocarcinomas. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2011, 24: 1237-47. PMID: 21552209, PMCID: PMC3155013, DOI: 10.1038/modpathol.2011.74.
- Zheng L, Foley K, Huang L, Leubner A, Mo G, Olino K, Edil BH, Mizuma M, Sharma R, Le DT, Anders RA, Illei PB, Van Eyk JE, Maitra A, Laheru D, Jaffee EM. Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer. PloS One 2011, 6: e19390. PMID: 21572519, PMCID: PMC3084841, DOI: 10.1371/journal.pone.0019390.
- Matthaei H, Hong SM, Mayo SC, Dal Molin M, Olino K, Venkat R, Goggins M, Herman JM, Edil BH, Wolfgang CL, Cameron JL, Schulick RD, Maitra A, Hruban RH. Presence of pancreatic intraepithelial neoplasia in the pancreatic transection margin does not influence outcome in patients with R0 resected pancreatic cancer. Indian Journal Of Surgical Oncology 2011, 2: 9-15. PMID: 22696140, PMCID: PMC3373004, DOI: 10.1007/s13193-011-0073-7.
- Yoshimura K, Olino K, Edil BH, Schulick RD, Oka M. Immuno- and gene-therapeutic strategies targeted against cancer (mainly focusing on pancreatic cancer). Surgery Today 2010, 40: 404-10. PMID: 20425541, DOI: 10.1007/s00595-009-4120-8.
- Winter JM, Cameron JL, Olino K, Herman JM, de Jong MC, Hruban RH, Wolfgang CL, Eckhauser F, Edil BH, Choti MA, Schulick RD, Pawlik TM. Clinicopathologic analysis of ampullary neoplasms in 450 patients: implications for surgical strategy and long-term prognosis. Journal Of Gastrointestinal Surgery : Official Journal Of The Society For Surgery Of The Alimentary Tract 2010, 14: 379-87. PMID: 19911239, DOI: 10.1007/s11605-009-1080-7.
- Yoshimura K, Meckel KF, Laird LS, Chia CY, Park JJ, Olino KL, Tsunedomi R, Harada T, Iizuka N, Hazama S, Kato Y, Keller JW, Thompson JM, Chang F, Romer LH, Jain A, Iacobuzio-Donahue C, Oka M, Pardoll DM, Schulick RD. Integrin alpha2 mediates selective metastasis to the liver. Cancer Research 2009, 69: 7320-8. PMID: 19738067, PMCID: PMC4857201, DOI: 10.1158/0008-5472.CAN-09-0315.
- Blackford A, Serrano OK, Wolfgang CL, Parmigiani G, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Cameron JL, Olino K, Schulick R, Winter J, Herman JM, Laheru D, Klein AP, Vogelstein B, Kinzler KW, Velculescu VE, Hruban RH. SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2009, 15: 4674-9. PMID: 19584151, PMCID: PMC2819274, DOI: 10.1158/1078-0432.CCR-09-0227.
- Blackford A, Parmigiani G, Kensler TW, Wolfgang C, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Klein A, Cameron JL, Olino K, Schulick R, Winter J, Vogelstein B, Velculescu VE, Kinzler KW, Hruban RH. Genetic mutations associated with cigarette smoking in pancreatic cancer. Cancer Research 2009, 69: 3681-8. PMID: 19351817, PMCID: PMC2669837, DOI: 10.1158/0008-5472.CAN-09-0015.
- Melanoma Program
- Surgery
- Surgical Oncology
- Yale Cancer Center
- Smilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
- Smilow Cancer Hospital Melanoma ProgramYale New Haven Shoreline Medical Center111 Goose LaneGuilford, CT 06437
- Smilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
- Smilow Cancer Hospital Melanoma ProgramYale New Haven Shoreline Medical Center111 Goose LaneGuilford, CT 06437