- Yale Bone CenterDana Clinic Building789 Howard Avenue, Ste 2nd FloorNew Haven, CT 06519
John Wysolmerski, MD
Endocrinology
Telehealth is available
Patient type treated
Adult
Accepting new patients
Yes
Referral required
From physicians only
Board Certified in
Internal Medicine
Titles
- Professor of Medicine (Endocrinology)
Education & Training
- FellowYale University School of Medicine (1993)
- Intern & ResidentTufts New England Medical School (1989)
- MDYale University (1986)
- BSYale University, Biology (1982)
Additional Information
Honors & Recognitions
- Co-Chair: 4th International Symposium on the Calcium Sensing Receptor (2019)
- Co-Chair: Mammary Gland Biology Gordon Research Conference (2013)
- Appointed as Standing Member: ICER Study Section, NIH (2012)
- President of Interurban Clinical Club: Interurban Clinical Club (2010)
- Interurban Clinical Club Councilor: Interurban Clinical Club (2007)
- The Anast Lectureship: Boston Children's Hospital and Brigham and Woman's Hosptital (2006)
- ASCI Membership: ASCI (2002)
- Sir William Osler Young Investigator Award: Interurban Clinical Club (2002)
- Cissy Hornung Research Award: CT Chapter of the American Cancer Society (2001)
- Most Outstanding Abstract of Yearly Meeting: American Society for Bone and Mineral Metabolsim (2001)
Board Certifications
- AB of Internal Medicine, Internal Medicine (1989)
Professional Service
- LionHeart Grant Review Committee, Yale Cancer Center (2021 - Present): Member
- Internal Medicine Department Compensation Committee (2020 - Present): Member
- Internal Medicine Appointments and Promotions Committee (2017 - 2019): Member
- Iva Dostanic Award Committee (2017 - Present): Member
- NIH, ICER Study Section (2012 - 2018): Standing Member of ICER Study Section, NIH
- NIH, ICER Study Section (2011): ICER Study Section
- Internal Scholar Review Committee (2010 - 2019): Member
- Yale Center for Small Molecule Discovery Advisory Committee (2010 - 2012): Member
- DOD Breast Cancer Research Program, Endocrine Review Panel (2010): Review Editorial Board
- Canadian Cancer Society (2009): Ad-hoc reviewer
Publications
- Guise TA, Wysolmerski JJ. Cancer-Associated Hypercalcemia. Reply. The New England Journal Of Medicine 2022, 386: 2540. PMID: 35767456, DOI: 10.1056/NEJMc2206287.
- PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development.Grinman DY, Boras-Granic K, Takyar FM, Dann P, Hens JR, Marmol C, Lee J, Choi J, Chodosh LA, Sola MEG, Wysolmerski JJ. PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development. Breast Cancer Research : BCR 2022, 24: 30. PMID: 35440032, PMCID: PMC9020078, DOI: 10.1186/s13058-022-01523-1.
- Guise TA, Wysolmerski JJ. Cancer-Associated Hypercalcemia. The New England Journal Of Medicine 2022, 386: 1443-1451. PMID: 35417639, DOI: 10.1056/NEJMcp2113128.
- Jeong J, Shin JH, Li W, Hong JY, Lim J, Hwang JY, Chung JJ, Yan Q, Liu Y, Choi J, Wysolmerski J. MAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells. Cell Reports 2021, 37: 110160. PMID: 34965434, PMCID: PMC8762588, DOI: 10.1016/j.celrep.2021.110160.
- Jeong J, Kadegowda AKG, Meyer TJ, Jenkins LM, Dinan JC, Wysolmerski JJ, Weigert R, Mather IH. The butyrophilin 1a1 knockout mouse revisited: Ablation of Btn1a1 leads to concurrent cell death and renewal in the mammary epithelium during lactation. FASEB BioAdvances 2021, 3: 971-997. PMID: 34938960, PMCID: PMC8664049, DOI: 10.1096/fba.2021-00059.
- Grinman D, Athonvarungkul D, Wysolmerski J, Jeong J. Calcium Metabolism and Breast Cancer: Echoes of Lactation? Current Opinion In Endocrine And Metabolic Research 2020, 15: 63-70. PMID: 33299957, PMCID: PMC7720883, DOI: 10.1016/j.coemr.2020.11.006.
- Jeong J, Kim W, Hens J, Dann P, Schedin P, Friedman PA, Wysolmerski JJ. NHERF1 Is Required for Localization of PMCA2 and Suppression of Early Involution in the Female Lactating Mammary Gland. Endocrinology 2019, 160: 1797-1810. PMID: 31087002, PMCID: PMC6619491, DOI: 10.1210/en.2019-00230.
- Lotinun S, Ishihara Y, Nagano K, Kiviranta R, Carpentier VT, Neff L, Parkman V, Ide N, Hu D, Dann P, Brooks D, Bouxsein ML, Wysolmerski J, Gori F, Baron R. Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression. The Journal Of Clinical Investigation 2019, 129: 3058-3071. PMID: 31112135, PMCID: PMC6668688, DOI: 10.1172/JCI122936.
- Jeong J, Choi J, Kim W, Dann P, Takyar F, Gefter JV, Friedman PA, Wysolmerski J. Inhibition of ezrin causes PKCα-mediated internalization of erbb2/HER2 tyrosine kinase in breast cancer cells. The Journal Of Biological Chemistry 2019, 294: 887-901. PMID: 30463939, PMCID: PMC6341383, DOI: 10.1074/jbc.RA118.004143.
- Zwick RK, Rudolph MC, Shook BA, Holtrup B, Roth E, Lei V, Van Keymeulen A, Seewaldt V, Kwei S, Wysolmerski J, Rodeheffer MS, Horsley V. Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation. Nature Communications 2018, 9: 3592. PMID: 30181538, PMCID: PMC6123393, DOI: 10.1038/s41467-018-05911-0.
- Jeong J, VanHouten JN, Kim W, Dann P, Sullivan C, Choi J, Sneddon WB, Friedman PA, Wysolmerski JJ. The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2. The Journal Of Biological Chemistry 2017, 292: 6555-6568. PMID: 28235801, PMCID: PMC5399107, DOI: 10.1074/jbc.M116.770883.
- Jeong J, Kim W, Kim LK, VanHouten J, Wysolmerski JJ. HER2 signaling regulates HER2 localization and membrane retention. PloS One 2017, 12: e0174849. PMID: 28369073, PMCID: PMC5378417, DOI: 10.1371/journal.pone.0174849.
- Kim W, Takyar FM, Swan K, Jeong J, VanHouten J, Sullivan C, Dann P, Yu H, Fiaschi-Taesch N, Chang W, Wysolmerski J. Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone-Related Protein. Cancer Research 2016, 76: 5348-60. PMID: 27450451, PMCID: PMC5026591, DOI: 10.1158/0008-5472.CAN-15-2614.
- Jeong J, VanHouten JN, Dann P, Kim W, Sullivan C, Yu H, Liotta L, Espina V, Stern DF, Friedman PA, Wysolmerski JJ. PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: E282-90. PMID: 26729871, PMCID: PMC4725473, DOI: 10.1073/pnas.1516138113.
- Kim W, Wysolmerski JJ. Calcium-Sensing Receptor in Breast Physiology and Cancer. Frontiers In Physiology 2016, 7: 440. PMID: 27746743, PMCID: PMC5043011, DOI: 10.3389/fphys.2016.00440.
- Ardeshirpour L, Dumitru C, Dann P, Sterpka J, VanHouten J, Kim W, Kostenuik P, Wysolmerski J. OPG Treatment Prevents Bone Loss During Lactation But Does Not Affect Milk Production or Maternal Calcium Metabolism. Endocrinology 2015, 156: 2762-73. PMID: 25961842, PMCID: PMC4511126, DOI: 10.1210/en.2015-1232.
- Boras-Granic K, Dann P, Wysolmerski JJ. Embryonic cells contribute directly to the quiescent stem cell population in the adult mouse mammary gland. Breast Cancer Research : BCR 2014, 16: 487. PMID: 25467960, PMCID: PMC4308878, DOI: 10.1186/s13058-014-0487-6.
- Boras-Granic K, Dann P, Vanhouten J, Karaplis A, Wysolmerski J. Deletion of the nuclear localization sequences and C-terminus of PTHrP impairs embryonic mammary development but also inhibits PTHrP production. PloS One 2014, 9: e90418. PMID: 24785493, PMCID: PMC4006745, DOI: 10.1371/journal.pone.0090418.
- Mamillapalli R, VanHouten J, Dann P, Bikle D, Chang W, Brown E, Wysolmerski J. Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual. Endocrinology 2013, 154: 3031-42. PMID: 23782944, PMCID: PMC3749485, DOI: 10.1210/en.2012-2195.
- Wysolmerski JJ. Osteocytes remove and replace perilacunar mineral during reproductive cycles. Bone 2013, 54: 230-6. PMID: 23352996, PMCID: PMC3624069, DOI: 10.1016/j.bone.2013.01.025.
- Vanhouten JN, Wysolmerski JJ. The calcium-sensing receptor in the breast. Best Practice & Research. Clinical Endocrinology & Metabolism 2013, 27: 403-14. PMID: 23856268, PMCID: PMC3713417, DOI: 10.1016/j.beem.2013.02.011.
- Hiremath M, Wysolmerski J. Parathyroid hormone-related protein specifies the mammary mesenchyme and regulates embryonic mammary development. Journal Of Mammary Gland Biology And Neoplasia 2013, 18: 171-7. PMID: 23640717, PMCID: PMC3696739, DOI: 10.1007/s10911-013-9283-7.
- Espina V, Wysolmerski J, Edmiston K, Liotta LA. Attacking breast cancer at the preinvasion stage by targeting autophagy. Women's Health (London, England) 2013, 9: 157-70. PMID: 23477322, PMCID: PMC3779365, DOI: 10.2217/whe.13.5.
- Wysolmerski JJ. Osteocytic osteolysis: time for a second look? BoneKEy Reports 2012, 1: 229. PMID: 24363929, PMCID: PMC3868715, DOI: 10.1038/bonekey.2012.229.
- Hiremath M, Dann P, Fischer J, Butterworth D, Boras-Granic K, Hens J, Van Houten J, Shi W, Wysolmerski J. Parathyroid hormone-related protein activates Wnt signaling to specify the embryonic mammary mesenchyme. Development (Cambridge, England) 2012, 139: 4239-49. PMID: 23034629, PMCID: PMC3478689, DOI: 10.1242/dev.080671.
- Wysolmerski JJ. Parathyroid hormone-related protein: an update. The Journal Of Clinical Endocrinology And Metabolism 2012, 97: 2947-56. PMID: 22745236, PMCID: PMC3431578, DOI: 10.1210/jc.2012-2142.
- Qing H, Ardeshirpour L, Pajevic PD, Dusevich V, Jähn K, Kato S, Wysolmerski J, Bonewald LF. Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2012, 27: 1018-29. PMID: 22308018, PMCID: PMC3770147, DOI: 10.1002/jbmr.1567.
- Boras-Granic K, Wysolmerski JJ. PTHrP and breast cancer: more than hypercalcemia and bone metastases. Breast Cancer Research : BCR 2012, 14: 307. PMID: 22546075, PMCID: PMC3446368, DOI: 10.1186/bcr3129.
- Liu XS, Ardeshirpour L, VanHouten JN, Shane E, Wysolmerski JJ. Site-specific changes in bone microarchitecture, mineralization, and stiffness during lactation and after weaning in mice. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2012, 27: 865-75. PMID: 22189918, DOI: 10.1002/jbmr.1503.
- Kirby BJ, Ardeshirpour L, Woodrow JP, Wysolmerski JJ, Sims NA, Karaplis AC, Kovacs CS. Skeletal recovery after weaning does not require PTHrP. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2011, 26: 1242-51. PMID: 21308774, PMCID: PMC3179289, DOI: 10.1002/jbmr.339.
- Boras-Granic K, VanHouten J, Hiremath M, Wysolmerski J. Parathyroid hormone-related protein is not required for normal ductal or alveolar development in the post-natal mammary gland. PloS One 2011, 6: e27278. PMID: 22087279, PMCID: PMC3210770, DOI: 10.1371/journal.pone.0027278.
- Ardeshirpour L, Brian S, Dann P, VanHouten J, Wysolmerski J. Increased PTHrP and decreased estrogens alter bone turnover but do not reproduce the full effects of lactation on the skeleton. Endocrinology 2010, 151: 5591-601. PMID: 21047946, PMCID: PMC2999486, DOI: 10.1210/en.2010-0566.
- VanHouten J, Sullivan C, Bazinet C, Ryoo T, Camp R, Rimm DL, Chung G, Wysolmerski J. PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 11405-10. PMID: 20534448, PMCID: PMC2895115, DOI: 10.1073/pnas.0911186107.
- Cowin P, Wysolmerski J. Molecular mechanisms guiding embryonic mammary gland development. Cold Spring Harbor Perspectives In Biology 2010, 2: a003251. PMID: 20484386, PMCID: PMC2869520, DOI: 10.1101/cshperspect.a003251.
- Mamillapalli R, Wysolmerski J. The calcium-sensing receptor couples to Galpha(s) and regulates PTHrP and ACTH secretion in pituitary cells. The Journal Of Endocrinology 2010, 204: 287-97. PMID: 20032198, PMCID: PMC3777408, DOI: 10.1677/JOE-09-0183.
- Wysolmerski JJ. Interactions between breast, bone, and brain regulate mineral and skeletal metabolism during lactation. Annals Of The New York Academy Of Sciences 2010, 1192: 161-9. PMID: 20392232, PMCID: PMC3777748, DOI: 10.1111/j.1749-6632.2009.05249.x.
- Coletta RD, McCoy EL, Burns V, Kawakami K, McManaman JL, Wysolmerski JJ, Ford HL. Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis. BMC Developmental Biology 2010, 10: 4. PMID: 20074369, PMCID: PMC2823684, DOI: 10.1186/1471-213X-10-4.
- Hens J, Dann P, Hiremath M, Pan TC, Chodosh L, Wysolmerski J. Analysis of gene expression in PTHrP-/- mammary buds supports a role for BMP signaling and MMP2 in the initiation of ductal morphogenesis. Developmental Dynamics : An Official Publication Of The American Association Of Anatomists 2009, 238: 2713-24. PMID: 19795511, PMCID: PMC2862621, DOI: 10.1002/dvdy.22097.
- Mamillapalli R, VanHouten J, Zawalich W, Wysolmerski J. Switching of G-protein usage by the calcium-sensing receptor reverses its effect on parathyroid hormone-related protein secretion in normal versus malignant breast cells. The Journal Of Biological Chemistry 2008, 283: 24435-47. PMID: 18621740, PMCID: PMC2528989, DOI: 10.1074/jbc.M801738200.
- Boras-Granic K, Wysolmerski JJ. Wnt signaling in breast organogenesis. Organogenesis 2008, 4: 116-22. PMID: 19279723, PMCID: PMC2634257, DOI: 10.4161/org.4.2.5858.
- VanHouten JN, Neville MC, Wysolmerski JJ. The calcium-sensing receptor regulates plasma membrane calcium adenosine triphosphatase isoform 2 activity in mammary epithelial cells: a mechanism for calcium-regulated calcium transport into milk. Endocrinology 2007, 148: 5943-54. PMID: 17823248, PMCID: PMC7108505, DOI: 10.1210/en.2007-0850.
- VanHouten JN, Wysolmerski JJ. Transcellular calcium transport in mammary epithelial cells. Journal Of Mammary Gland Biology And Neoplasia 2007, 12: 223-35. PMID: 17999165, DOI: 10.1007/s10911-007-9057-1.
- Ardeshirpour L, Dann P, Adams DJ, Nelson T, VanHouten J, Horowitz MC, Wysolmerski JJ. Weaning triggers a decrease in receptor activator of nuclear factor-kappaB ligand expression, widespread osteoclast apoptosis, and rapid recovery of bone mass after lactation in mice. Endocrinology 2007, 148: 3875-86. PMID: 17495007, DOI: 10.1210/en.2006-1467.
- Hens JR, Dann P, Zhang JP, Harris S, Robinson GW, Wysolmerski J. BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Development (Cambridge, England) 2007, 134: 1221-30. PMID: 17301089, DOI: 10.1242/dev.000182.
- Ardeshirpour L, Dann P, Pollak M, Wysolmerski J, VanHouten J. The calcium-sensing receptor regulates PTHrP production and calcium transport in the lactating mammary gland. Bone 2006, 38: 787-93. PMID: 16377269, DOI: 10.1016/j.bone.2005.11.009.
- VanHouten JN, Yu N, Rimm D, Dotto J, Arnold A, Wysolmerski JJ, Udelsman R. Hypercalcemia of malignancy due to ectopic transactivation of the parathyroid hormone gene. The Journal Of Clinical Endocrinology And Metabolism 2006, 91: 580-3. PMID: 16263810, DOI: 10.1210/jc.2005-2095.
- Horwitz MJ, Tedesco MB, Sereika SM, Syed MA, Garcia-Ocaña A, Bisello A, Hollis BW, Rosen CJ, Wysolmerski JJ, Dann P, Gundberg C, Stewart AF. Continuous PTH and PTHrP infusion causes suppression of bone formation and discordant effects on 1,25(OH)2 vitamin D. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2005, 20: 1792-803. PMID: 16160737, DOI: 10.1359/JBMR.050602.
- Hens JR, Wilson KM, Dann P, Chen X, Horowitz MC, Wysolmerski JJ. TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2005, 20: 1103-13. PMID: 15940363, DOI: 10.1359/JBMR.050210.
- Wysolmerski J. Calcium handling by the lactating breast and its relationship to calcium-related complications of breast cancer. Journal Of Mammary Gland Biology And Neoplasia 2005, 10: 101-3. PMID: 16025217, DOI: 10.1007/s10911-005-5393-1.
- DeMauro S, Wysolmerski J. Hypercalcemia in breast cancer: an echo of bone mobilization during lactation? Journal Of Mammary Gland Biology And Neoplasia 2005, 10: 157-67. PMID: 16025222, DOI: 10.1007/s10911-005-5398-9.
- Hens JR, Wysolmerski JJ. Key stages of mammary gland development: molecular mechanisms involved in the formation of the embryonic mammary gland. Breast Cancer Research : BCR 2005, 7: 220-4. PMID: 16168142, PMCID: PMC1242158, DOI: 10.1186/bcr1306.
- Chu EY, Hens J, Andl T, Kairo A, Yamaguchi TP, Brisken C, Glick A, Wysolmerski JJ, Millar SE. Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development (Cambridge, England) 2004, 131: 4819-29. PMID: 15342465, DOI: 10.1242/dev.01347.
- VanHouten J, Dann P, McGeoch G, Brown EM, Krapcho K, Neville M, Wysolmerski JJ. The calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport. The Journal Of Clinical Investigation 2004, 113: 598-608. PMID: 14966569, PMCID: PMC338258, DOI: 10.1172/JCI18776.
- VanHouten JN, Wysolmerski JJ. Low estrogen and high parathyroid hormone-related peptide levels contribute to accelerated bone resorption and bone loss in lactating mice. Endocrinology 2003, 144: 5521-9. PMID: 14500568, DOI: 10.1210/en.2003-0892.
- VanHouten JN, Dann P, Stewart AF, Watson CJ, Pollak M, Karaplis AC, Wysolmerski JJ. Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation. The Journal Of Clinical Investigation 2003, 112: 1429-36. PMID: 14597768, PMCID: PMC228471, DOI: 10.1172/JCI19504.
- Kifor O, Moore FD, Delaney M, Garber J, Hendy GN, Butters R, Gao P, Cantor TL, Kifor I, Brown EM, Wysolmerski J. A syndrome of hypocalciuric hypercalcemia caused by autoantibodies directed at the calcium-sensing receptor. The Journal Of Clinical Endocrinology And Metabolism 2003, 88: 60-72. PMID: 12519831, DOI: 10.1210/jc.2002-020249.
- Wysolmerski JJ, Dann PR, Zelazny E, Dunbar ME, Insogna KL, Guise TA, Perkins AS. Overexpression of parathyroid hormone-related protein causes hypercalcemia but not bone metastases in a murine model of mammary tumorigenesis. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2002, 17: 1164-70. PMID: 12096830, DOI: 10.1359/jbmr.2002.17.7.1164.
- Abdalkhani A, Sellers R, Gent J, Wulitich H, Childress S, Stein B, Boissy RE, Wysolmerski JJ, Foley J. Nipple connective tissue and its development: insights from the K14-PTHrP mouse. Mechanisms Of Development 2002, 115: 63-77. PMID: 12049768, DOI: 10.1016/s0925-4773(02)00092-8.
- Wysolmerski JJ. The evolutionary origins of maternal calcium and bone metabolism during lactation. Journal Of Mammary Gland Biology And Neoplasia 2002, 7: 267-76. PMID: 12751891, DOI: 10.1023/a:1022800716196.
- Cruz DN, Brickel HM, Wysolmerski JJ, Gundberg CG, Simpson CA, Kliger AS, Lorber MI, Basadonna GP, Friedman AL, Insogna KL, Bia MJ. Treatment of osteoporosis and osteopenia in long-term renal transplant patients with alendronate. American Journal Of Transplantation : Official Journal Of The American Society Of Transplantation And The American Society Of Transplant Surgeons 2002, 2: 62-7. PMID: 12095058, DOI: 10.1034/j.1600-6143.2002.020111.x.
- Dunbar ME, Dann P, Brown CW, Van Houton J, Dreyer B, Philbrick WP, Wysolmerski JJ. Temporally regulated overexpression of parathyroid hormone-related protein in the mammary gland reveals distinct fetal and pubertal phenotypes. The Journal Of Endocrinology 2001, 171: 403-16. PMID: 11739006.
- Cruz DN, Wysolmerski JJ, Brickel HM, Gundberg CG, Simpson CA, Mitnick MA, Kliger AS, Lorber MI, Basadonna GP, Friedman AL, Insogna KL, Bia MJ. Parameters of high bone-turnover predict bone loss in renal transplant patients: a longitudinal study. Transplantation 2001, 72: 83-8. PMID: 11468539, DOI: 10.1097/00007890-200107150-00017.
- Wysolmerski JJ, Cormier S, Philbrick WM, Dann P, Zhang JP, Roume J, Delezoide AL, Silve C. Absence of functional type 1 parathyroid hormone (PTH)/PTH-related protein receptors in humans is associated with abnormal breast development and tooth impaction. The Journal Of Clinical Endocrinology And Metabolism 2001, 86: 1788-94. PMID: 11297619, DOI: 10.1210/jcem.86.4.7404.
- Foley J, Dann P, Hong J, Cosgrove J, Dreyer B, Rimm D, Dunbar M, Philbrick W, Wysolmerski J. Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development. Development (Cambridge, England) 2001, 128: 513-25. PMID: 11171335.
- Dunbar ME, Wysolmerski JJ. Mammary ductal and alveolar development: lesson learned from genetically manipulated mice. Microscopy Research And Technique 2001, 52: 163-70. PMID: 11169864, DOI: 10.1002/1097-0029(20010115)52:2<163::AID-JEMT1002>3.0.CO;2-R.
- Cayco AV, Wysolmerski J, Simpson C, Mitnick MA, Gundberg C, Kliger A, Lorber M, Silver D, Basadonna G, Friedman A, Insogna K, Cruz D, Bia M. Posttransplant bone disease: evidence for a high bone resorption state. Transplantation 2000, 70: 1722-8. PMID: 11152104.
- Foley J, King CS, Jiménez JA, Wysolmerski JJ, Philbrick WM. Activation of PTHrP gene expression in squamous carcinoma cell lines by mutant isoforms of the tumor suppressor p53. Oncology Research 2000, 12: 71-81. PMID: 11132926.
- Foley J, Wysolmerski JJ, Missero C, King CS, Philbrick WM. Regulation of parathyroid hormone-related protein gene expression in murine keratinocytes by E1A isoforms: a role for basal promoter and Ets-1 site. Molecular And Cellular Endocrinology 1999, 156: 13-23. PMID: 10612419, DOI: 10.1016/s0303-7207(99)00151-3.
- Dunbar ME, Dann PR, Robinson GW, Hennighausen L, Zhang JP, Wysolmerski JJ. Parathyroid hormone-related protein signaling is necessary for sexual dimorphism during embryonic mammary development. Development (Cambridge, England) 1999, 126: 3485-93. PMID: 10409496.
- Dunbar ME, Wysolmerski JJ. Parathyroid hormone-related protein: a developmental regulatory molecule necessary for mammary gland development. Journal Of Mammary Gland Biology And Neoplasia 1999, 4: 21-34. PMID: 10219904, DOI: 10.1023/a:1018700502518.
- Foley J, Longely BJ, Wysolmerski JJ, Dreyer BE, Broadus AE, Philbrick WM. PTHrP regulates epidermal differentiation in adult mice. The Journal Of Investigative Dermatology 1998, 111: 1122-8. PMID: 9856827, DOI: 10.1046/j.1523-1747.1998.00428.x.
- Dunbar ME, Young P, Zhang JP, McCaughern-Carucci J, Lanske B, Orloff JJ, Karaplis A, Cunha G, Wysolmerski JJ. Stromal cells are critical targets in the regulation of mammary ductal morphogenesis by parathyroid hormone-related protein. Developmental Biology 1998, 203: 75-89. PMID: 9806774, DOI: 10.1006/dbio.1998.9029.
- Wysolmerski JJ, Philbrick WM, Dunbar ME, Lanske B, Kronenberg H, Broadus AE. Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development. Development (Cambridge, England) 1998, 125: 1285-94. PMID: 9477327.
- Wysolmerski JJ, Stewart AF. The physiology of parathyroid hormone-related protein: an emerging role as a developmental factor. Annual Review Of Physiology 1998, 60: 431-60. PMID: 9558472, DOI: 10.1146/annurev.physiol.60.1.431.
- Dunbar ME, Wysolmerski JJ, Broadus AE. Parathyroid hormone-related protein: from hypercalcemia of malignancy to developmental regulatory molecule. The American Journal Of The Medical Sciences 1996, 312: 287-94. PMID: 8969618, DOI: 10.1097/00000441-199612000-00007.
- Foley J, Wysolmerski JJ, Broadus AE, Philbrick WM. Parathyroid hormone-related protein gene expression in human squamous carcinoma cells is repressed by mutant isoforms of p53. Cancer Research 1996, 56: 4056-62. PMID: 8752179.
- Wysolmerski JJ, Vasavada R, Foley J, Weir EC, Burtis WJ, Kukreja SC, Guise TA, Broadus AE, Philbrick WM. Transactivation of the PTHrP gene in squamous carcinomas predicts the occurrence of hypercalcemia in athymic mice. Cancer Research 1996, 56: 1043-9. PMID: 8640759.
- Philbrick WM, Wysolmerski JJ, Galbraith S, Holt E, Orloff JJ, Yang KH, Vasavada RC, Weir EC, Broadus AE, Stewart AF. Defining the roles of parathyroid hormone-related protein in normal physiology. Physiological Reviews 1996, 76: 127-73. PMID: 8592727, DOI: 10.1152/physrev.1996.76.1.127.
- Wysolmerski JJ, McCaughern-Carucci JF, Daifotis AG, Broadus AE, Philbrick WM. Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development. Development (Cambridge, England) 1995, 121: 3539-47. PMID: 8582268.
- Wysolmerski JJ, Broadus AE, Zhou J, Fuchs E, Milstone LM, Philbrick WM. Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 1133-7. PMID: 7508121, PMCID: PMC521468, DOI: 10.1073/pnas.91.3.1133.
- Wysolmerski JJ, Broadus AE. Hypercalcemia of malignancy: the central role of parathyroid hormone-related protein. Annual Review Of Medicine 1994, 45: 189-200. PMID: 8198376, DOI: 10.1146/annurev.med.45.1.189.
- Vasavada RC, Wysolmerski JJ, Broadus AE, Philbrick WM. Identification and characterization of a GC-rich promoter of the human parathyroid hormone-related peptide gene. Molecular Endocrinology (Baltimore, Md.) 1993, 7: 273-82. PMID: 8469240, DOI: 10.1210/mend.7.2.8469240.
- Burtis WJ, Wu T, Bunch C, Wysolmerski JJ, Insogna KL, Weir EC, Broadus AE, Stewart AF. Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy. The Journal Of Biological Chemistry 1987, 262: 7151-6. PMID: 3584110.
Departments and Programs
Locations
- Yale Bone CenterDana Clinic Building789 Howard Avenue, Ste 2nd FloorNew Haven, CT 06519
Titles
- Professor of Medicine (Endocrinology)
Education & Training
- FellowYale University School of Medicine (1993)
- Intern & ResidentTufts New England Medical School (1989)
- MDYale University (1986)
- BSYale University, Biology (1982)
Additional Information
Honors & Recognitions
- Co-Chair: 4th International Symposium on the Calcium Sensing Receptor (2019)
- Co-Chair: Mammary Gland Biology Gordon Research Conference (2013)
- Appointed as Standing Member: ICER Study Section, NIH (2012)
- President of Interurban Clinical Club: Interurban Clinical Club (2010)
- Interurban Clinical Club Councilor: Interurban Clinical Club (2007)
- The Anast Lectureship: Boston Children's Hospital and Brigham and Woman's Hosptital (2006)
- ASCI Membership: ASCI (2002)
- Sir William Osler Young Investigator Award: Interurban Clinical Club (2002)
- Cissy Hornung Research Award: CT Chapter of the American Cancer Society (2001)
- Most Outstanding Abstract of Yearly Meeting: American Society for Bone and Mineral Metabolsim (2001)
Board Certifications
- AB of Internal Medicine, Internal Medicine (1989)
Professional Service
- LionHeart Grant Review Committee, Yale Cancer Center (2021 - Present): Member
- Internal Medicine Department Compensation Committee (2020 - Present): Member
- Internal Medicine Appointments and Promotions Committee (2017 - 2019): Member
- Iva Dostanic Award Committee (2017 - Present): Member
- NIH, ICER Study Section (2012 - 2018): Standing Member of ICER Study Section, NIH
- NIH, ICER Study Section (2011): ICER Study Section
- Internal Scholar Review Committee (2010 - 2019): Member
- Yale Center for Small Molecule Discovery Advisory Committee (2010 - 2012): Member
- DOD Breast Cancer Research Program, Endocrine Review Panel (2010): Review Editorial Board
- Canadian Cancer Society (2009): Ad-hoc reviewer
Publications
- Guise TA, Wysolmerski JJ. Cancer-Associated Hypercalcemia. Reply. The New England Journal Of Medicine 2022, 386: 2540. PMID: 35767456, DOI: 10.1056/NEJMc2206287.
- PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development.Grinman DY, Boras-Granic K, Takyar FM, Dann P, Hens JR, Marmol C, Lee J, Choi J, Chodosh LA, Sola MEG, Wysolmerski JJ. PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development. Breast Cancer Research : BCR 2022, 24: 30. PMID: 35440032, PMCID: PMC9020078, DOI: 10.1186/s13058-022-01523-1.
- Guise TA, Wysolmerski JJ. Cancer-Associated Hypercalcemia. The New England Journal Of Medicine 2022, 386: 1443-1451. PMID: 35417639, DOI: 10.1056/NEJMcp2113128.
- Jeong J, Shin JH, Li W, Hong JY, Lim J, Hwang JY, Chung JJ, Yan Q, Liu Y, Choi J, Wysolmerski J. MAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells. Cell Reports 2021, 37: 110160. PMID: 34965434, PMCID: PMC8762588, DOI: 10.1016/j.celrep.2021.110160.
- Jeong J, Kadegowda AKG, Meyer TJ, Jenkins LM, Dinan JC, Wysolmerski JJ, Weigert R, Mather IH. The butyrophilin 1a1 knockout mouse revisited: Ablation of Btn1a1 leads to concurrent cell death and renewal in the mammary epithelium during lactation. FASEB BioAdvances 2021, 3: 971-997. PMID: 34938960, PMCID: PMC8664049, DOI: 10.1096/fba.2021-00059.
- Grinman D, Athonvarungkul D, Wysolmerski J, Jeong J. Calcium Metabolism and Breast Cancer: Echoes of Lactation? Current Opinion In Endocrine And Metabolic Research 2020, 15: 63-70. PMID: 33299957, PMCID: PMC7720883, DOI: 10.1016/j.coemr.2020.11.006.
- Jeong J, Kim W, Hens J, Dann P, Schedin P, Friedman PA, Wysolmerski JJ. NHERF1 Is Required for Localization of PMCA2 and Suppression of Early Involution in the Female Lactating Mammary Gland. Endocrinology 2019, 160: 1797-1810. PMID: 31087002, PMCID: PMC6619491, DOI: 10.1210/en.2019-00230.
- Lotinun S, Ishihara Y, Nagano K, Kiviranta R, Carpentier VT, Neff L, Parkman V, Ide N, Hu D, Dann P, Brooks D, Bouxsein ML, Wysolmerski J, Gori F, Baron R. Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression. The Journal Of Clinical Investigation 2019, 129: 3058-3071. PMID: 31112135, PMCID: PMC6668688, DOI: 10.1172/JCI122936.
- Jeong J, Choi J, Kim W, Dann P, Takyar F, Gefter JV, Friedman PA, Wysolmerski J. Inhibition of ezrin causes PKCα-mediated internalization of erbb2/HER2 tyrosine kinase in breast cancer cells. The Journal Of Biological Chemistry 2019, 294: 887-901. PMID: 30463939, PMCID: PMC6341383, DOI: 10.1074/jbc.RA118.004143.
- Zwick RK, Rudolph MC, Shook BA, Holtrup B, Roth E, Lei V, Van Keymeulen A, Seewaldt V, Kwei S, Wysolmerski J, Rodeheffer MS, Horsley V. Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation. Nature Communications 2018, 9: 3592. PMID: 30181538, PMCID: PMC6123393, DOI: 10.1038/s41467-018-05911-0.
- Jeong J, VanHouten JN, Kim W, Dann P, Sullivan C, Choi J, Sneddon WB, Friedman PA, Wysolmerski JJ. The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2. The Journal Of Biological Chemistry 2017, 292: 6555-6568. PMID: 28235801, PMCID: PMC5399107, DOI: 10.1074/jbc.M116.770883.
- Jeong J, Kim W, Kim LK, VanHouten J, Wysolmerski JJ. HER2 signaling regulates HER2 localization and membrane retention. PloS One 2017, 12: e0174849. PMID: 28369073, PMCID: PMC5378417, DOI: 10.1371/journal.pone.0174849.
- Kim W, Takyar FM, Swan K, Jeong J, VanHouten J, Sullivan C, Dann P, Yu H, Fiaschi-Taesch N, Chang W, Wysolmerski J. Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone-Related Protein. Cancer Research 2016, 76: 5348-60. PMID: 27450451, PMCID: PMC5026591, DOI: 10.1158/0008-5472.CAN-15-2614.
- Jeong J, VanHouten JN, Dann P, Kim W, Sullivan C, Yu H, Liotta L, Espina V, Stern DF, Friedman PA, Wysolmerski JJ. PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: E282-90. PMID: 26729871, PMCID: PMC4725473, DOI: 10.1073/pnas.1516138113.
- Kim W, Wysolmerski JJ. Calcium-Sensing Receptor in Breast Physiology and Cancer. Frontiers In Physiology 2016, 7: 440. PMID: 27746743, PMCID: PMC5043011, DOI: 10.3389/fphys.2016.00440.
- Ardeshirpour L, Dumitru C, Dann P, Sterpka J, VanHouten J, Kim W, Kostenuik P, Wysolmerski J. OPG Treatment Prevents Bone Loss During Lactation But Does Not Affect Milk Production or Maternal Calcium Metabolism. Endocrinology 2015, 156: 2762-73. PMID: 25961842, PMCID: PMC4511126, DOI: 10.1210/en.2015-1232.
- Boras-Granic K, Dann P, Wysolmerski JJ. Embryonic cells contribute directly to the quiescent stem cell population in the adult mouse mammary gland. Breast Cancer Research : BCR 2014, 16: 487. PMID: 25467960, PMCID: PMC4308878, DOI: 10.1186/s13058-014-0487-6.
- Boras-Granic K, Dann P, Vanhouten J, Karaplis A, Wysolmerski J. Deletion of the nuclear localization sequences and C-terminus of PTHrP impairs embryonic mammary development but also inhibits PTHrP production. PloS One 2014, 9: e90418. PMID: 24785493, PMCID: PMC4006745, DOI: 10.1371/journal.pone.0090418.
- Mamillapalli R, VanHouten J, Dann P, Bikle D, Chang W, Brown E, Wysolmerski J. Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual. Endocrinology 2013, 154: 3031-42. PMID: 23782944, PMCID: PMC3749485, DOI: 10.1210/en.2012-2195.
- Wysolmerski JJ. Osteocytes remove and replace perilacunar mineral during reproductive cycles. Bone 2013, 54: 230-6. PMID: 23352996, PMCID: PMC3624069, DOI: 10.1016/j.bone.2013.01.025.
- Vanhouten JN, Wysolmerski JJ. The calcium-sensing receptor in the breast. Best Practice & Research. Clinical Endocrinology & Metabolism 2013, 27: 403-14. PMID: 23856268, PMCID: PMC3713417, DOI: 10.1016/j.beem.2013.02.011.
- Hiremath M, Wysolmerski J. Parathyroid hormone-related protein specifies the mammary mesenchyme and regulates embryonic mammary development. Journal Of Mammary Gland Biology And Neoplasia 2013, 18: 171-7. PMID: 23640717, PMCID: PMC3696739, DOI: 10.1007/s10911-013-9283-7.
- Espina V, Wysolmerski J, Edmiston K, Liotta LA. Attacking breast cancer at the preinvasion stage by targeting autophagy. Women's Health (London, England) 2013, 9: 157-70. PMID: 23477322, PMCID: PMC3779365, DOI: 10.2217/whe.13.5.
- Wysolmerski JJ. Osteocytic osteolysis: time for a second look? BoneKEy Reports 2012, 1: 229. PMID: 24363929, PMCID: PMC3868715, DOI: 10.1038/bonekey.2012.229.
- Hiremath M, Dann P, Fischer J, Butterworth D, Boras-Granic K, Hens J, Van Houten J, Shi W, Wysolmerski J. Parathyroid hormone-related protein activates Wnt signaling to specify the embryonic mammary mesenchyme. Development (Cambridge, England) 2012, 139: 4239-49. PMID: 23034629, PMCID: PMC3478689, DOI: 10.1242/dev.080671.
- Wysolmerski JJ. Parathyroid hormone-related protein: an update. The Journal Of Clinical Endocrinology And Metabolism 2012, 97: 2947-56. PMID: 22745236, PMCID: PMC3431578, DOI: 10.1210/jc.2012-2142.
- Qing H, Ardeshirpour L, Pajevic PD, Dusevich V, Jähn K, Kato S, Wysolmerski J, Bonewald LF. Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2012, 27: 1018-29. PMID: 22308018, PMCID: PMC3770147, DOI: 10.1002/jbmr.1567.
- Boras-Granic K, Wysolmerski JJ. PTHrP and breast cancer: more than hypercalcemia and bone metastases. Breast Cancer Research : BCR 2012, 14: 307. PMID: 22546075, PMCID: PMC3446368, DOI: 10.1186/bcr3129.
- Liu XS, Ardeshirpour L, VanHouten JN, Shane E, Wysolmerski JJ. Site-specific changes in bone microarchitecture, mineralization, and stiffness during lactation and after weaning in mice. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2012, 27: 865-75. PMID: 22189918, DOI: 10.1002/jbmr.1503.
- Kirby BJ, Ardeshirpour L, Woodrow JP, Wysolmerski JJ, Sims NA, Karaplis AC, Kovacs CS. Skeletal recovery after weaning does not require PTHrP. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2011, 26: 1242-51. PMID: 21308774, PMCID: PMC3179289, DOI: 10.1002/jbmr.339.
- Boras-Granic K, VanHouten J, Hiremath M, Wysolmerski J. Parathyroid hormone-related protein is not required for normal ductal or alveolar development in the post-natal mammary gland. PloS One 2011, 6: e27278. PMID: 22087279, PMCID: PMC3210770, DOI: 10.1371/journal.pone.0027278.
- Ardeshirpour L, Brian S, Dann P, VanHouten J, Wysolmerski J. Increased PTHrP and decreased estrogens alter bone turnover but do not reproduce the full effects of lactation on the skeleton. Endocrinology 2010, 151: 5591-601. PMID: 21047946, PMCID: PMC2999486, DOI: 10.1210/en.2010-0566.
- VanHouten J, Sullivan C, Bazinet C, Ryoo T, Camp R, Rimm DL, Chung G, Wysolmerski J. PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 11405-10. PMID: 20534448, PMCID: PMC2895115, DOI: 10.1073/pnas.0911186107.
- Cowin P, Wysolmerski J. Molecular mechanisms guiding embryonic mammary gland development. Cold Spring Harbor Perspectives In Biology 2010, 2: a003251. PMID: 20484386, PMCID: PMC2869520, DOI: 10.1101/cshperspect.a003251.
- Mamillapalli R, Wysolmerski J. The calcium-sensing receptor couples to Galpha(s) and regulates PTHrP and ACTH secretion in pituitary cells. The Journal Of Endocrinology 2010, 204: 287-97. PMID: 20032198, PMCID: PMC3777408, DOI: 10.1677/JOE-09-0183.
- Wysolmerski JJ. Interactions between breast, bone, and brain regulate mineral and skeletal metabolism during lactation. Annals Of The New York Academy Of Sciences 2010, 1192: 161-9. PMID: 20392232, PMCID: PMC3777748, DOI: 10.1111/j.1749-6632.2009.05249.x.
- Coletta RD, McCoy EL, Burns V, Kawakami K, McManaman JL, Wysolmerski JJ, Ford HL. Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis. BMC Developmental Biology 2010, 10: 4. PMID: 20074369, PMCID: PMC2823684, DOI: 10.1186/1471-213X-10-4.
- Hens J, Dann P, Hiremath M, Pan TC, Chodosh L, Wysolmerski J. Analysis of gene expression in PTHrP-/- mammary buds supports a role for BMP signaling and MMP2 in the initiation of ductal morphogenesis. Developmental Dynamics : An Official Publication Of The American Association Of Anatomists 2009, 238: 2713-24. PMID: 19795511, PMCID: PMC2862621, DOI: 10.1002/dvdy.22097.
- Mamillapalli R, VanHouten J, Zawalich W, Wysolmerski J. Switching of G-protein usage by the calcium-sensing receptor reverses its effect on parathyroid hormone-related protein secretion in normal versus malignant breast cells. The Journal Of Biological Chemistry 2008, 283: 24435-47. PMID: 18621740, PMCID: PMC2528989, DOI: 10.1074/jbc.M801738200.
- Boras-Granic K, Wysolmerski JJ. Wnt signaling in breast organogenesis. Organogenesis 2008, 4: 116-22. PMID: 19279723, PMCID: PMC2634257, DOI: 10.4161/org.4.2.5858.
- VanHouten JN, Neville MC, Wysolmerski JJ. The calcium-sensing receptor regulates plasma membrane calcium adenosine triphosphatase isoform 2 activity in mammary epithelial cells: a mechanism for calcium-regulated calcium transport into milk. Endocrinology 2007, 148: 5943-54. PMID: 17823248, PMCID: PMC7108505, DOI: 10.1210/en.2007-0850.
- VanHouten JN, Wysolmerski JJ. Transcellular calcium transport in mammary epithelial cells. Journal Of Mammary Gland Biology And Neoplasia 2007, 12: 223-35. PMID: 17999165, DOI: 10.1007/s10911-007-9057-1.
- Ardeshirpour L, Dann P, Adams DJ, Nelson T, VanHouten J, Horowitz MC, Wysolmerski JJ. Weaning triggers a decrease in receptor activator of nuclear factor-kappaB ligand expression, widespread osteoclast apoptosis, and rapid recovery of bone mass after lactation in mice. Endocrinology 2007, 148: 3875-86. PMID: 17495007, DOI: 10.1210/en.2006-1467.
- Hens JR, Dann P, Zhang JP, Harris S, Robinson GW, Wysolmerski J. BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Development (Cambridge, England) 2007, 134: 1221-30. PMID: 17301089, DOI: 10.1242/dev.000182.
- Ardeshirpour L, Dann P, Pollak M, Wysolmerski J, VanHouten J. The calcium-sensing receptor regulates PTHrP production and calcium transport in the lactating mammary gland. Bone 2006, 38: 787-93. PMID: 16377269, DOI: 10.1016/j.bone.2005.11.009.
- VanHouten JN, Yu N, Rimm D, Dotto J, Arnold A, Wysolmerski JJ, Udelsman R. Hypercalcemia of malignancy due to ectopic transactivation of the parathyroid hormone gene. The Journal Of Clinical Endocrinology And Metabolism 2006, 91: 580-3. PMID: 16263810, DOI: 10.1210/jc.2005-2095.
- Horwitz MJ, Tedesco MB, Sereika SM, Syed MA, Garcia-Ocaña A, Bisello A, Hollis BW, Rosen CJ, Wysolmerski JJ, Dann P, Gundberg C, Stewart AF. Continuous PTH and PTHrP infusion causes suppression of bone formation and discordant effects on 1,25(OH)2 vitamin D. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2005, 20: 1792-803. PMID: 16160737, DOI: 10.1359/JBMR.050602.
- Hens JR, Wilson KM, Dann P, Chen X, Horowitz MC, Wysolmerski JJ. TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2005, 20: 1103-13. PMID: 15940363, DOI: 10.1359/JBMR.050210.
- Wysolmerski J. Calcium handling by the lactating breast and its relationship to calcium-related complications of breast cancer. Journal Of Mammary Gland Biology And Neoplasia 2005, 10: 101-3. PMID: 16025217, DOI: 10.1007/s10911-005-5393-1.
- DeMauro S, Wysolmerski J. Hypercalcemia in breast cancer: an echo of bone mobilization during lactation? Journal Of Mammary Gland Biology And Neoplasia 2005, 10: 157-67. PMID: 16025222, DOI: 10.1007/s10911-005-5398-9.
- Hens JR, Wysolmerski JJ. Key stages of mammary gland development: molecular mechanisms involved in the formation of the embryonic mammary gland. Breast Cancer Research : BCR 2005, 7: 220-4. PMID: 16168142, PMCID: PMC1242158, DOI: 10.1186/bcr1306.
- Chu EY, Hens J, Andl T, Kairo A, Yamaguchi TP, Brisken C, Glick A, Wysolmerski JJ, Millar SE. Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development (Cambridge, England) 2004, 131: 4819-29. PMID: 15342465, DOI: 10.1242/dev.01347.
- VanHouten J, Dann P, McGeoch G, Brown EM, Krapcho K, Neville M, Wysolmerski JJ. The calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport. The Journal Of Clinical Investigation 2004, 113: 598-608. PMID: 14966569, PMCID: PMC338258, DOI: 10.1172/JCI18776.
- VanHouten JN, Wysolmerski JJ. Low estrogen and high parathyroid hormone-related peptide levels contribute to accelerated bone resorption and bone loss in lactating mice. Endocrinology 2003, 144: 5521-9. PMID: 14500568, DOI: 10.1210/en.2003-0892.
- VanHouten JN, Dann P, Stewart AF, Watson CJ, Pollak M, Karaplis AC, Wysolmerski JJ. Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation. The Journal Of Clinical Investigation 2003, 112: 1429-36. PMID: 14597768, PMCID: PMC228471, DOI: 10.1172/JCI19504.
- Kifor O, Moore FD, Delaney M, Garber J, Hendy GN, Butters R, Gao P, Cantor TL, Kifor I, Brown EM, Wysolmerski J. A syndrome of hypocalciuric hypercalcemia caused by autoantibodies directed at the calcium-sensing receptor. The Journal Of Clinical Endocrinology And Metabolism 2003, 88: 60-72. PMID: 12519831, DOI: 10.1210/jc.2002-020249.
- Wysolmerski JJ, Dann PR, Zelazny E, Dunbar ME, Insogna KL, Guise TA, Perkins AS. Overexpression of parathyroid hormone-related protein causes hypercalcemia but not bone metastases in a murine model of mammary tumorigenesis. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2002, 17: 1164-70. PMID: 12096830, DOI: 10.1359/jbmr.2002.17.7.1164.
- Abdalkhani A, Sellers R, Gent J, Wulitich H, Childress S, Stein B, Boissy RE, Wysolmerski JJ, Foley J. Nipple connective tissue and its development: insights from the K14-PTHrP mouse. Mechanisms Of Development 2002, 115: 63-77. PMID: 12049768, DOI: 10.1016/s0925-4773(02)00092-8.
- Wysolmerski JJ. The evolutionary origins of maternal calcium and bone metabolism during lactation. Journal Of Mammary Gland Biology And Neoplasia 2002, 7: 267-76. PMID: 12751891, DOI: 10.1023/a:1022800716196.
- Cruz DN, Brickel HM, Wysolmerski JJ, Gundberg CG, Simpson CA, Kliger AS, Lorber MI, Basadonna GP, Friedman AL, Insogna KL, Bia MJ. Treatment of osteoporosis and osteopenia in long-term renal transplant patients with alendronate. American Journal Of Transplantation : Official Journal Of The American Society Of Transplantation And The American Society Of Transplant Surgeons 2002, 2: 62-7. PMID: 12095058, DOI: 10.1034/j.1600-6143.2002.020111.x.
- Dunbar ME, Dann P, Brown CW, Van Houton J, Dreyer B, Philbrick WP, Wysolmerski JJ. Temporally regulated overexpression of parathyroid hormone-related protein in the mammary gland reveals distinct fetal and pubertal phenotypes. The Journal Of Endocrinology 2001, 171: 403-16. PMID: 11739006.
- Cruz DN, Wysolmerski JJ, Brickel HM, Gundberg CG, Simpson CA, Mitnick MA, Kliger AS, Lorber MI, Basadonna GP, Friedman AL, Insogna KL, Bia MJ. Parameters of high bone-turnover predict bone loss in renal transplant patients: a longitudinal study. Transplantation 2001, 72: 83-8. PMID: 11468539, DOI: 10.1097/00007890-200107150-00017.
- Wysolmerski JJ, Cormier S, Philbrick WM, Dann P, Zhang JP, Roume J, Delezoide AL, Silve C. Absence of functional type 1 parathyroid hormone (PTH)/PTH-related protein receptors in humans is associated with abnormal breast development and tooth impaction. The Journal Of Clinical Endocrinology And Metabolism 2001, 86: 1788-94. PMID: 11297619, DOI: 10.1210/jcem.86.4.7404.
- Foley J, Dann P, Hong J, Cosgrove J, Dreyer B, Rimm D, Dunbar M, Philbrick W, Wysolmerski J. Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development. Development (Cambridge, England) 2001, 128: 513-25. PMID: 11171335.
- Dunbar ME, Wysolmerski JJ. Mammary ductal and alveolar development: lesson learned from genetically manipulated mice. Microscopy Research And Technique 2001, 52: 163-70. PMID: 11169864, DOI: 10.1002/1097-0029(20010115)52:2<163::AID-JEMT1002>3.0.CO;2-R.
- Cayco AV, Wysolmerski J, Simpson C, Mitnick MA, Gundberg C, Kliger A, Lorber M, Silver D, Basadonna G, Friedman A, Insogna K, Cruz D, Bia M. Posttransplant bone disease: evidence for a high bone resorption state. Transplantation 2000, 70: 1722-8. PMID: 11152104.
- Foley J, King CS, Jiménez JA, Wysolmerski JJ, Philbrick WM. Activation of PTHrP gene expression in squamous carcinoma cell lines by mutant isoforms of the tumor suppressor p53. Oncology Research 2000, 12: 71-81. PMID: 11132926.
- Foley J, Wysolmerski JJ, Missero C, King CS, Philbrick WM. Regulation of parathyroid hormone-related protein gene expression in murine keratinocytes by E1A isoforms: a role for basal promoter and Ets-1 site. Molecular And Cellular Endocrinology 1999, 156: 13-23. PMID: 10612419, DOI: 10.1016/s0303-7207(99)00151-3.
- Dunbar ME, Dann PR, Robinson GW, Hennighausen L, Zhang JP, Wysolmerski JJ. Parathyroid hormone-related protein signaling is necessary for sexual dimorphism during embryonic mammary development. Development (Cambridge, England) 1999, 126: 3485-93. PMID: 10409496.
- Dunbar ME, Wysolmerski JJ. Parathyroid hormone-related protein: a developmental regulatory molecule necessary for mammary gland development. Journal Of Mammary Gland Biology And Neoplasia 1999, 4: 21-34. PMID: 10219904, DOI: 10.1023/a:1018700502518.
- Foley J, Longely BJ, Wysolmerski JJ, Dreyer BE, Broadus AE, Philbrick WM. PTHrP regulates epidermal differentiation in adult mice. The Journal Of Investigative Dermatology 1998, 111: 1122-8. PMID: 9856827, DOI: 10.1046/j.1523-1747.1998.00428.x.
- Dunbar ME, Young P, Zhang JP, McCaughern-Carucci J, Lanske B, Orloff JJ, Karaplis A, Cunha G, Wysolmerski JJ. Stromal cells are critical targets in the regulation of mammary ductal morphogenesis by parathyroid hormone-related protein. Developmental Biology 1998, 203: 75-89. PMID: 9806774, DOI: 10.1006/dbio.1998.9029.
- Wysolmerski JJ, Philbrick WM, Dunbar ME, Lanske B, Kronenberg H, Broadus AE. Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development. Development (Cambridge, England) 1998, 125: 1285-94. PMID: 9477327.
- Wysolmerski JJ, Stewart AF. The physiology of parathyroid hormone-related protein: an emerging role as a developmental factor. Annual Review Of Physiology 1998, 60: 431-60. PMID: 9558472, DOI: 10.1146/annurev.physiol.60.1.431.
- Dunbar ME, Wysolmerski JJ, Broadus AE. Parathyroid hormone-related protein: from hypercalcemia of malignancy to developmental regulatory molecule. The American Journal Of The Medical Sciences 1996, 312: 287-94. PMID: 8969618, DOI: 10.1097/00000441-199612000-00007.
- Foley J, Wysolmerski JJ, Broadus AE, Philbrick WM. Parathyroid hormone-related protein gene expression in human squamous carcinoma cells is repressed by mutant isoforms of p53. Cancer Research 1996, 56: 4056-62. PMID: 8752179.
- Wysolmerski JJ, Vasavada R, Foley J, Weir EC, Burtis WJ, Kukreja SC, Guise TA, Broadus AE, Philbrick WM. Transactivation of the PTHrP gene in squamous carcinomas predicts the occurrence of hypercalcemia in athymic mice. Cancer Research 1996, 56: 1043-9. PMID: 8640759.
- Philbrick WM, Wysolmerski JJ, Galbraith S, Holt E, Orloff JJ, Yang KH, Vasavada RC, Weir EC, Broadus AE, Stewart AF. Defining the roles of parathyroid hormone-related protein in normal physiology. Physiological Reviews 1996, 76: 127-73. PMID: 8592727, DOI: 10.1152/physrev.1996.76.1.127.
- Wysolmerski JJ, McCaughern-Carucci JF, Daifotis AG, Broadus AE, Philbrick WM. Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development. Development (Cambridge, England) 1995, 121: 3539-47. PMID: 8582268.
- Wysolmerski JJ, Broadus AE, Zhou J, Fuchs E, Milstone LM, Philbrick WM. Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 1133-7. PMID: 7508121, PMCID: PMC521468, DOI: 10.1073/pnas.91.3.1133.
- Wysolmerski JJ, Broadus AE. Hypercalcemia of malignancy: the central role of parathyroid hormone-related protein. Annual Review Of Medicine 1994, 45: 189-200. PMID: 8198376, DOI: 10.1146/annurev.med.45.1.189.
- Vasavada RC, Wysolmerski JJ, Broadus AE, Philbrick WM. Identification and characterization of a GC-rich promoter of the human parathyroid hormone-related peptide gene. Molecular Endocrinology (Baltimore, Md.) 1993, 7: 273-82. PMID: 8469240, DOI: 10.1210/mend.7.2.8469240.
- Burtis WJ, Wu T, Bunch C, Wysolmerski JJ, Insogna KL, Weir EC, Broadus AE, Stewart AF. Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy. The Journal Of Biological Chemistry 1987, 262: 7151-6. PMID: 3584110.
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- Yale Bone CenterDana Clinic Building789 Howard Avenue, Ste 2nd FloorNew Haven, CT 06519