Henry Rinder, MD
Internal Medicine, Hematology & Oncology, Pathology, Hematopathology
Biography
Henry Rinder, MD, is a hematologist, helping bolster research and clinical care surrounding various blood disorders, including bleeding and clotting diseases, anemias, and blood complications from other diseases.
Dr. Rinder's research focuses on cell-based diagnostics and basic biology principles involving inflammation and hemostasis—the body's reaction to an injury; this reaction stops the bleeding and allows the body to begin healing.
Through his clinical and research work, Dr. Rinder has established himself as an authority in hematology, including becoming an author on the 4th and 5th editions of Hillman's Hematology in Clinical Practice (McGraw-Hill).
Dr. Rinder is a professor of laboratory medicine and internal medicine (hematology) at Yale School of Medicine.
Titles
- Professor of Laboratory Medicine and of Medicine (Hematology)
- Vice Chair for Clinical Affairs, Laboratory Medicine
- Associate Director, Yale Pathology Residency Program
- Director, Clinical Hematology Laboratory
Education & Training
- FellowYale University School of Medicine (1992)
- FellowYale University School of Medicine (1990)
- Chief ResidentMaine Medical Center (1988)
- ResidentMaine Medical Center (1987)
- MDUniversity of Vermont (1984)
Languages Spoken
- English
- Français (French)
Additional Information
Honors & Recognitions
- Past President: Academy of Clinical Laboratory Physicians & Scientists (2016)
- Michele D. Raible Lecturer: American Society for Clinical Pathology (2015)
- 2013 President's Award: American Society for Clinical Pathology (2013)
Board Certifications
- AB of Pathology, Clinical Pathology (1994, recertified: 2014)
- AB of Internal Medicine, Internal Medicine (1987)
Publications
- Jacobs J, Sharma D, Stephens L, Villalba C, Rinder H, Woo J, Wheeler A, Gerberi D, Goel R, Tormey C, Booth G, Bloch E, Adkins B. Thrombosis risk with haemoglobin C trait and haemoglobin C disease: A systematic review. British Journal Of Haematology 2024, 204: 1500-1506. PMID: 38291731, DOI: 10.1111/bjh.19313.
- Burke O, Jacobs J, Tormey C, Rinder H, Villalba C, Lee E, Campos J, Abels E, Yurtsever N. Heidenhain variant of Creutzfeldt-Jakob disease masquerading as neuromyelitis optica spectrum disorder: recognizing when apheresis is not the answer. Lab Medicine 2023, lmad107. PMID: 38142129, DOI: 10.1093/labmed/lmad107.
- Restrepo V, Pine A, Butt A, Chang E, Bar N, Baluha A, Brooks A, Chirico G, Curran J, Dumont A, Obura-Wilkes P, Rinder H, Tormey C, Nassiri N, Lee A, Prozora S. Comprehensive Characterization of Coagulation Parameters in Venous Malformations. Blood 2023, 142: 27. DOI: 10.1182/blood-2023-190609.
- Gu S, Gallagher P, Butt A, Gu V, Lezon-Geyda K, Schulz V, Prozora S, Lee A, Neparidze N, Bar N, Martin K, Cornell J, Chirico G, Chakraborty R, Rinder H, Hwa J, Bona R. Multimodality Platelet Evaluation By Mass Cytometry and Genetic Analysis in Patients with Bleeding Disorders. Blood 2023, 142: 1197. DOI: 10.1182/blood-2023-177946.
- Campos J, Abels E, Rinder H, Tormey C, Jacobs J. Botulism mimicking Guillain‐Barre syndrome: The question of plasma exchange in an unusual case of acute paralysis. Journal Of Clinical Apheresis 2023, 38: 760-763. PMID: 37519071, DOI: 10.1002/jca.22081.
- Puzo C, Tormey C, Rinder H, Siddon A. Optimizing Donor Chimerism Threshold for Next-Generation Sequencing Monitoring of Measurable Residual Disease Post-Allogeneic Stem Cell Transplantation for Myeloid Neoplasms. Transplantation And Cellular Therapy 2023, 29: 459.e1-459.e4. PMID: 37062510, DOI: 10.1016/j.jtct.2023.04.005.
- Khan W, Tormey C, Rinder H, Siddon A. Quantitative Risk for Single-Positive Lupus Anticoagulant Results With Different Anticoagulants. American Journal Of Clinical Pathology 2023, 159: 417-419. PMID: 36940149, DOI: 10.1093/ajcp/aqac183.
- Binns T, Tormey C, Rinder H. Platelet production and kinetics. 2022, 158-167. DOI: 10.1002/9781119719809.ch15.
- Tyagi T, Jain K, Gu S, Qiu M, Gu V, Melchinger H, Rinder H, Martin K, Gardiner E, Lee A, Tang W, Hwa J. A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences. Nature Cardiovascular Research 2022, 1: 223-237. PMID: 37502132, PMCID: PMC10373053, DOI: 10.1038/s44161-022-00021-z.
- Jacobs JW, Gisriel SD, Iyer K, Rinder HM. Concomitant factor VIII inhibitor and lupus anticoagulant in an asymptomatic patient. Journal Of Thrombosis And Thrombolysis 2021, 53: 945-949. PMID: 34697688, PMCID: PMC8544916, DOI: 10.1007/s11239-021-02591-4.
- Gisriel S, Rinder H, Siddon A. Criteria for Ordering Myeloid Neoplasm Next-Generation Sequencing to Optimize Personalized Patient Care and Cost. Blood 2020, 136: 39-40. DOI: 10.1182/blood-2020-139035.
- Gupta G, Hendrickson J, Bahel P, Siddon A, Rinder H, Tormey C. Assessment of Factor V Activity in Apheresis Platelet Units: Implications for Management of FV Deficiency. American Journal Of Clinical Pathology 2020, 154: s6-s7. DOI: 10.1093/ajcp/aqaa137.011.
- Zanetto A, Rinder H, Deng Y, Ciarleglio M, Wilson F, Bulato C, Simioni P, Garcia-Tsao G. Acute kidney injury is associated with reversible platelet dysfunction in hospitalized patients with decompensated cirrhosis. Digestive And Liver Disease 2020, 52: e13. DOI: 10.1016/j.dld.2019.12.031.
- Chandler J, Bahel P, Siddon A, Torres R, Rinder H, Tormey C. A Modified Approach to Fibrinogen Replacement in the Setting of Dysfibrinogenemia. American Journal Of Clinical Pathology 2016, 146: 326. DOI: 10.1093/ajcp/aqw160.005.
- Tormey C, Rinder H. Platelet production and kinetics. 2016, 206-214. DOI: 10.1002/9781119013020.ch17.
- Schulz W, Durant T, Rinder H, Tormey C, Torres R, Smith B, Hager K, Howe J, Siddon A. Impact of Molecular Clonality on Survival in Acute Myeloid Leukemia. Blood 2015, 126: 1385. DOI: 10.1182/blood.v126.23.1385.1385.
- Siddon AJ, Rinder HM. Pathology Consultation on Evaluating Prognosis in Incidental Monoclonal Lymphocytosis and Chronic Lymphocytic Leukemia. American Journal Of Clinical Pathology 2013, 139: 708-712. PMID: 23690112, DOI: 10.1309/ajcplir4gzwx3xka.
- Perrotta P, Parsons J, Rinder H, Snyder E. Chapter 62 Platelet Transfusion Medicine. 2013, 1275-1303. DOI: 10.1016/b978-0-12-387837-3.00062-6.
- Smith B, Rinder H. Chapter 52 Cardiopulmonary Bypass. 2013, 1075-1096. DOI: 10.1016/b978-0-12-387837-3.00052-3.
- Streimish I, Bizzarro M, Northrup V, Wang C, Renna S, Koval N, Li FY, Ehrenkranz R, Rinder HM, Bhandari V. Neutrophil CD64 as a Diagnostic Marker in Neonatal Sepsis. The Pediatric Infectious Disease Journal 2012, 31: 777-781. PMID: 22481422, PMCID: PMC3375383, DOI: 10.1097/inf.0b013e318256fb07.
- Siddon AJ, Torres R, Rinder HM, Smith BR, Howe JG, Tormey CA. Normalized CCND1 expression has prognostic value in mantle cell lymphoma. British Journal Of Haematology 2012, 158: 551-553. PMID: 22671703, DOI: 10.1111/j.1365-2141.2012.09181.x.
- Hager K, Jennings K, Hosono S, Howell S, Gruen JR, Rivkees SA, Tartaglia NR, Rinder HM. Molecular diagnostic testing for Klinefelter syndrome and other male sex chromosome aneuploidies. International Journal Of Pediatric Endocrinology 2012, 2012: 8. PMID: 22524164, PMCID: PMC3411476, DOI: 10.1186/1687-9856-2012-8.
- Rinder HM, Grimes MM, Wagner J, Bennett BD. Senior Pathology Resident In-Service Examination Scores Correlate With Outcomes of the American Board of Pathology Certifying Examinations. American Journal Of Clinical Pathology 2011, 136: 499-506. PMID: 21917671, DOI: 10.1309/ajcpa7o4bbuglsww.
- Rivkees S, Hager K, Hosono S, Wise A, Li P, Rinder H, Gruen J. A Highly Sensitive, High-Throughput Assay for the Detection of Turner Syndrome. Obstetrical & Gynecological Survey 2011, 66: 421-422. DOI: 10.1097/ogx.0b013e3182338c32.
- Hematology in Clinical PracticeHillman RS, Ault KA, Leporrier M, Rinder HM editors. Hematology in Clinical Practice, Fifth Ed. McGraw-Hill, New York 2011
- Torres R, Rinder H. Chapter 54 Disorders of Hemostasis Thrombosis. 2010, 580-591. DOI: 10.1016/b978-1-4160-6109-0.00054-x.
- Rinder C, Rinder H. Chapter 52 Normal Hemostasis. 2010, 555-563. DOI: 10.1016/b978-1-4160-6109-0.00052-6.
- Rinder H, Tomer A. Platelet Production, Kinetics, and Hemostasis. 2009, 149-167. DOI: 10.1002/9781444303513.ch10.
- Smith B, Rinder H, Rinder C. Chapter 59 Cardiopulmonary bypass. 2007, 1077-1095. DOI: 10.1016/b978-012369367-9/50821-1.
- Kurup V, Transue S, Wu Y, Rinder HM, Barash P, Dewar M. Cardiac surgery in a patient with heparin-induced thrombocytopenia--cautions with use of the direct thrombin inhibitor, argatroban. Connecticut Medicine 2006, 70: 245-50. PMID: 16768071.
- Murphy S, Rinder H, Smith B. Utility of in vitro tests in predicting the in vivo viability of stored PLTs. Transfusion 2004, 44: 618-619. PMID: 15043581, DOI: 10.1111/j.1537-2995.2004.00355.x.
- Brouse C, Nguyen K, Greilich P, Rinder H, Jessen M, DiMaio J, Smith B, Eberhart R. “OFF-PUMP” CORONARY ARTERY BYPASS SURGERY REDUCES MONOCYTE-PLATELET CONJUGATE FORMATION. ASAIO Journal 2002, 48: 169. DOI: 10.1097/00002480-200203000-00179.
- Griffin M, Rinder H, Smith B, Tracey J, Kriz N, Li C, Rinder C. The Effects of Heparin, Protamine, and Heparin/Protamine Reversal on Platelet Function Under Conditions of Arterial Shear Stress. Anesthesia & Analgesia 2001, 93: 20-27. PMID: 11429331, DOI: 10.1097/00000539-200107000-00005.
- Rinder H, Gagnier R, Souhrada M, Wood C. SAT0063 Bleeding time and platelet function in normal volunteers receiving meloxicam. 2001, a173.1-a173. DOI: 10.1136/annrheumdis-2001.438.
- Perez L, Rinder H, Wang C, Tracey J, Maun N, Krause D. Xenotransplantation of immunodeficient mice with mobilized human blood CD34+ cells provides an in vivo model for human megakaryocytopoiesis and platelet production. Blood 2001, 97: 1635-1643. PMID: 11238102, DOI: 10.1182/blood.v97.6.1635.
- Margolin A, Avants S, Setaro J, Rinder H, Grupp L. Cocaine, HIV, and their cardiovascular effects: is there a role for ACE-inhibitor therapy? Drug And Alcohol Dependence 2000, 61: 35-45. PMID: 11064182, DOI: 10.1016/s0376-8716(00)00124-1.
- Pearson H, Ehrenkranz R, Rinder H, Riely C. Hemosiderosis in a Normal Child Secondary to Oral Iron Medication. Pediatrics 2000, 105: 429-430. PMID: 10654969, DOI: 10.1542/peds.105.2.429.
- Fitch J, Rollins S, Matis L, Alford B, Aranki S, Collard C, Dewar M, Elefteriades J, Hines R, Kopf G, Kraker P, Li L, O’Hara R, Rinder C, Rinder H, Shaw R, Smith B, Stahl G, Shernan S. Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass. Circulation 1999, 100: 2499-2506. PMID: 10604887, DOI: 10.1161/01.cir.100.25.2499.
- Rinder H, Arbini A, Snyder E. Optimal dosing and triggers for prophylactic use of platelet transfusions. Current Opinion In Hematology 1999, 6: 437. PMID: 10546800, DOI: 10.1097/00062752-199911000-00015.
- Rinder C, Rinder H, Johnson K, Smith M, Lee D, Tracey J, Polack G, Higgins P, Yeh C, Smith MD B. Role of C3 Cleavage in Monocyte Activation During Extracorporeal Circulation. Circulation 1999, 100: 553-558. PMID: 10430771, DOI: 10.1161/01.cir.100.5.553.
- Griffin M, Li C, Rinder H, Smith B, Rinder C. OPTIMAL HEPARIN-PROTAMINE REVERSAL RATIO. Anesthesia & Analgesia 1999, 88: 106sca.. DOI: 10.1097/00000539-199904001-00106.
- Mathew J, Fontes M, Phillips-Bute B, Rinder H, Herskowitz A, Smith B, Newman M, Rinder C. PLATELET ACTIVATION DURING CARDIOPULMONARY BYPASS PREDICTS POSTOPERATIVE NEUROCOGNITIVE DECLINE. Anesthesia & Analgesia 1999, 88: 109sca.. DOI: 10.1097/00000539-199904001-00109.
- Rinder H, Ault K. Platelet activation and its detection during the preparation of platelets for transfusion. Transfusion Medicine Reviews 1998, 12: 271-287. PMID: 9798270, DOI: 10.1016/s0887-7963(98)80003-5.
- Rollins S, Fitch J, Shernan S, Rinder C, Rinder H, Smith B, Collard C, Stahl G, Alford B, Li L, Matis L. Anti-C5 single chain antibody therapy blocks complement & leukocyte activation and reduces myocardial tissue damage in CPB patients. Molecular Immunology 1998, 35: 397. DOI: 10.1016/s0161-5890(98)90798-2.
- Varelas P, Sleight B, Rinder H, Sze G, Ment L. Stroke in a Neonate Heterozygous for Factor V Leiden. Pediatric Neurology 1998, 18: 262-264. PMID: 9568926, DOI: 10.1016/s0887-8994(97)00166-5.
- Rinder H, Schuster J, Rinder C, Wang C, Schweidler H, Smith B. Correlation of Thrombosis With Increased Platelet Turnover in Thrombocytosis. Blood 1998, 91: 1288-1294. PMID: 9454759, DOI: 10.1182/blood.v91.4.1288.
- Rinder H. Platelet function testing by flow cytometry. Clinical Laboratory Science 1998, 11: 365-72. PMID: 10345505.
- Grossman D, Heald P, Wang C, Rinder H. Activated protein C resistance and anticardiolipin antibodies in patients with venous leg ulcers. Journal Of The American Academy Of Dermatology 1997, 37: 409-413. DOI: 10.1016/s0190-9622(18)30738-2.
- Grossman D, Heald P, Wang C, Rinder H. Activated protein C resistance and anticardiolipin antibodies in patients with venous leg ulcers. Journal Of The American Academy Of Dermatology 1997, 37: 409-413. PMID: 9308555, DOI: 10.1016/s0190-9622(97)70141-5.
- Rinder C, Mathew J, Rinder H, Tracey J, Davis E, Smith B. Lymphocyte and monocyte subset changes during cardiopulmonary bypass: Effects of aging and gender. Translational Research 1997, 129: 592-602. PMID: 9178725, DOI: 10.1016/s0022-2143(97)90193-1.
- Rinder M, Richard R, Rinder H. Acquired von Willebrand's disease: A concise review. American Journal Of Hematology 1997, 54: 139-145. PMID: 9034288, DOI: 10.1002/(sici)1096-8652(199702)54:2<139::aid-ajh7>3.0.co;2-y.
- Tracey J, Rinder H. Characterization of the P-selectin ligand on human hematopoietic progenitors. Experimental Hematology 1996, 24: 1494-500. PMID: 8950232.
- HARRIS S, RINDER C, RINDER H, TRACEY J, SMITH B, HINES R. Nitroprusside Inhibition of Platelet Function Is Transient and Reversible by Catecholamine Priming. Survey Of Anesthesiology 1996, 40: 326. DOI: 10.1097/00132586-199610000-00069.
- Peterec S, Brennan S, Rinder H, Wnek J, Beardsley D. Reticulated platelet values in normal and thrombocytopenic neonates. The Journal Of Pediatrics 1996, 129: 269-274. PMID: 8765626, DOI: 10.1016/s0022-3476(96)70253-6.
- Harris S, Rinder C, Rinder H, Tracey J, Smith B, Hines R. Nitroprusside Inhibition of Platelet Function Is Transient and Reversible by Catecholamine Priming. Anesthesiology 1995, 83: 1145-1152.. PMID: 8533905, DOI: 10.1097/00000542-199512000-00003.
- Leitenberg D, Eisen R, Goldstein J, Busque L, Rinder H, Stys P, Katz M, Gilliland D, Smith B. Natural killer cell lymphoproliferative disease associated with neuropathy. The American Journal Of Medicine 1995, 99: 99-101. PMID: 7598151, DOI: 10.1016/s0002-9343(99)80112-0.
- Rinder H, Tracey J, Rinder C, Leitenberg D, Smith B. Neutrophil but not Monocyte Activation Inhibits P-Selectin-Mediated Platelet Adhesion*. Thrombosis And Haemostasis 1994, 72: 750-756. PMID: 7534948, DOI: 10.1055/s-0038-1648953.
- Rinder H, Bonan J, Anandan S, Rinder C, Rodrigues P, Smith B. Noninvasive measurement of platelet kinetics in normal and hypertensive pregnancies. American Journal Of Obstetrics And Gynecology 1994, 170: 117-122. DOI: 10.1016/s0002-9378(13)70291-6.
- Bonan J, Rinder H, Smith B. Determination of the percentage of thiazole orange (TO)‐positive, “reticulated” platelets using autologous erythrocyte TO fluorescence as an internal standard. Cytometry 1993, 14: 690-694. PMID: 8404376, DOI: 10.1002/cyto.990140615.
- Rinder C, Student L, Bonan J, Rinder H, Smith B. Aspirin Does Not Inhibit Adenosine Diphosphate-Induced Platelet α-Granule Release. Blood 1993, 82: 505-512. PMID: 7687162, DOI: 10.1182/blood.v82.2.505.505.
- Rinder C, Student L, Bonan J, Rinder H, Smith B. Aspirin does not inhibit adenosine diphosphate-induced platelet alpha- granule release. Blood 1993, 82: 505-512. DOI: 10.1182/blood.v82.2.505.bloodjournal822505.
- Ault K, Rinder H, Mitchell J, Carmody M, Vary C, Hillman R. The Significance of Platelets with Increased RNA Content (Reticulated Platelets) A Measure of the Rate of Thrombopoiesis. American Journal Of Clinical Pathology 1992, 98: 637-646. PMID: 1281383, DOI: 10.1093/ajcp/98.6.637.
- Rinder C, Bonan J, Rinder H, Mathew J, Hines R, Smith B. Cardiopulmonary Bypass Induces Leukocyte-Platelet Adhesion. Blood 1992, 79: 1201-1205. PMID: 1371416, DOI: 10.1182/blood.v79.5.1201.1201.
- Rinder C, Bonan J, Rinder H, Mathew J, Hines R, Smith B. Cardiopulmonary bypass induces leukocyte-platelet adhesion. Blood 1992, 79: 1201-1205. DOI: 10.1182/blood.v79.5.1201.bloodjournal7951201.
- Rinder H, Snyder E. Activation of platelet concentrate during preparation and storage. Blood Cells Molecules And Diseases 1992, 18: 445-56; discussion 457-60. PMID: 1283703.
- Rinder H, Bonan J, Rinder C, Ault K, Smith B. Activated and unactivated platelet adhesion to monocytes and neutrophils. Blood 1991, 78: 1760-9. PMID: 1717070, DOI: 10.1182/blood.v78.7.1760.bloodjournal7871760.
- Rinder H, Bonan J, Rinder C, Ault K, Smith B. Dynamics of leukocyte-platelet adhesion in whole blood. Blood 1991, 78: 1730-7. PMID: 1717069, DOI: 10.1182/blood.v78.7.1730.bloodjournal7871730.
- Rinder C, Mathew J, Rinder H, Bonan J, Ault K, Smith B. Modulation of Platelet Surface Adhesion Receptors during Cardiopulmonary Bypass. Anesthesiology 1991, 75: 563-570. PMID: 1718190, DOI: 10.1097/00000542-199110000-00004.
- Rinder H, Bonan J, Rinder C, Ault K, Smith B. Activated and Unactivated Platelet Adhesion to Monocytes and Neutrophils. Blood 1991, 78: 1760-1769. DOI: 10.1182/blood.v78.7.1760.1760.
- Rinder H, Bonan J, Rinder C, Ault K, Smith B. Dynamics of Leukocyte-Platelet Adhesion in Whole Blood. Blood 1991, 78: 1730-1737. DOI: 10.1182/blood.v78.7.1730.1730.
- Rinder C, Bohnert J, Rinder H, Mitchell J, Ault K, Hillman R. Platelet Activation and Aggregation during Cardiopulmonary Bypass. Anesthesiology 1991, 75: 388-393. PMID: 1716077, DOI: 10.1097/00000542-199109000-00002.
- Rinder H, Murphy M, Mitchell J, Stocks J, Ault K, Hillman R. Progressive platelet activation with storage: evidence for shortened survival of activated platelets after transfusion. Transfusion 1991, 31: 409-414. PMID: 1710840, DOI: 10.1046/j.1537-2995.1991.31591263195.x.
- Rinder C, Rinder H, Ault K, Smith B. A74 PLATELET RECEPTORS FOR ADHESIVE LIGANDS ARE DECREASED DURING CARDIOPULMONARY BYPASS. Anesthesiology 1990, 73: na. DOI: 10.1097/00000542-199009001-00074.
- Snyder E, Rinder H, Napychank P. In Vitro and In Vivo Evaluation of Platelet Transfusions Administered Through an Electromechanical Infusion Pump. American Journal Of Clinical Pathology 1990, 94: 77-80. PMID: 2360566, DOI: 10.1093/ajcp/94.1.77.
- Ault K, Rinder H, Mitchell J, Rinder C, Lambrew C, Hillman R. Correlated measurement of platelet release and aggregation in whole blood. Cytometry 1989, 10: 448-455. PMID: 2475308, DOI: 10.1002/cyto.990100413.
- RINDER C, D'AMATO S, RINDER H, COX P. Survival in complicated diphenhydramine overdose. Critical Care Medicine 1988, 16: 1161-1162. PMID: 3168512, DOI: 10.1097/00003246-198811000-00017.
- Rinder H, Murphy J, Higgins G. Impact of unusual gastrointestinal problems on the treatment of tricyclic antidepressant overdose. Annals Of Emergency Medicine 1988, 17: 1079-1081. PMID: 3177998, DOI: 10.1016/s0196-0644(88)80449-9.
- Bach M, Roediger J, Rinder H. Septic Anaerobic Jugular Phlebitis with Pulmonary Embolism: Problems in Management. Clinical Infectious Diseases 1988, 10: 424-427. PMID: 3375694, DOI: 10.1093/clinids/10.2.424.
- Rinder H, Rinder C. Cryptococcal meningitis and AIDS. Annals Of Emergency Medicine 1988, 17: 299. PMID: 3345031, DOI: 10.1016/s0196-0644(88)80148-3.
Departments and Programs
Biography
Henry Rinder, MD, is a hematologist, helping bolster research and clinical care surrounding various blood disorders, including bleeding and clotting diseases, anemias, and blood complications from other diseases.
Dr. Rinder's research focuses on cell-based diagnostics and basic biology principles involving inflammation and hemostasis—the body's reaction to an injury; this reaction stops the bleeding and allows the body to begin healing.
Through his clinical and research work, Dr. Rinder has established himself as an authority in hematology, including becoming an author on the 4th and 5th editions of Hillman's Hematology in Clinical Practice (McGraw-Hill).
Dr. Rinder is a professor of laboratory medicine and internal medicine (hematology) at Yale School of Medicine.
Titles
- Professor of Laboratory Medicine and of Medicine (Hematology)
- Vice Chair for Clinical Affairs, Laboratory Medicine
- Associate Director, Yale Pathology Residency Program
- Director, Clinical Hematology Laboratory
Education & Training
- FellowYale University School of Medicine (1992)
- FellowYale University School of Medicine (1990)
- Chief ResidentMaine Medical Center (1988)
- ResidentMaine Medical Center (1987)
- MDUniversity of Vermont (1984)
Languages Spoken
- English
- Français (French)
Additional Information
Honors & Recognitions
- Past President: Academy of Clinical Laboratory Physicians & Scientists (2016)
- Michele D. Raible Lecturer: American Society for Clinical Pathology (2015)
- 2013 President's Award: American Society for Clinical Pathology (2013)
Board Certifications
- AB of Pathology, Clinical Pathology (1994, recertified: 2014)
- AB of Internal Medicine, Internal Medicine (1987)
Publications
- Jacobs J, Sharma D, Stephens L, Villalba C, Rinder H, Woo J, Wheeler A, Gerberi D, Goel R, Tormey C, Booth G, Bloch E, Adkins B. Thrombosis risk with haemoglobin C trait and haemoglobin C disease: A systematic review. British Journal Of Haematology 2024, 204: 1500-1506. PMID: 38291731, DOI: 10.1111/bjh.19313.
- Burke O, Jacobs J, Tormey C, Rinder H, Villalba C, Lee E, Campos J, Abels E, Yurtsever N. Heidenhain variant of Creutzfeldt-Jakob disease masquerading as neuromyelitis optica spectrum disorder: recognizing when apheresis is not the answer. Lab Medicine 2023, lmad107. PMID: 38142129, DOI: 10.1093/labmed/lmad107.
- Restrepo V, Pine A, Butt A, Chang E, Bar N, Baluha A, Brooks A, Chirico G, Curran J, Dumont A, Obura-Wilkes P, Rinder H, Tormey C, Nassiri N, Lee A, Prozora S. Comprehensive Characterization of Coagulation Parameters in Venous Malformations. Blood 2023, 142: 27. DOI: 10.1182/blood-2023-190609.
- Gu S, Gallagher P, Butt A, Gu V, Lezon-Geyda K, Schulz V, Prozora S, Lee A, Neparidze N, Bar N, Martin K, Cornell J, Chirico G, Chakraborty R, Rinder H, Hwa J, Bona R. Multimodality Platelet Evaluation By Mass Cytometry and Genetic Analysis in Patients with Bleeding Disorders. Blood 2023, 142: 1197. DOI: 10.1182/blood-2023-177946.
- Campos J, Abels E, Rinder H, Tormey C, Jacobs J. Botulism mimicking Guillain‐Barre syndrome: The question of plasma exchange in an unusual case of acute paralysis. Journal Of Clinical Apheresis 2023, 38: 760-763. PMID: 37519071, DOI: 10.1002/jca.22081.
- Puzo C, Tormey C, Rinder H, Siddon A. Optimizing Donor Chimerism Threshold for Next-Generation Sequencing Monitoring of Measurable Residual Disease Post-Allogeneic Stem Cell Transplantation for Myeloid Neoplasms. Transplantation And Cellular Therapy 2023, 29: 459.e1-459.e4. PMID: 37062510, DOI: 10.1016/j.jtct.2023.04.005.
- Khan W, Tormey C, Rinder H, Siddon A. Quantitative Risk for Single-Positive Lupus Anticoagulant Results With Different Anticoagulants. American Journal Of Clinical Pathology 2023, 159: 417-419. PMID: 36940149, DOI: 10.1093/ajcp/aqac183.
- Binns T, Tormey C, Rinder H. Platelet production and kinetics. 2022, 158-167. DOI: 10.1002/9781119719809.ch15.
- Tyagi T, Jain K, Gu S, Qiu M, Gu V, Melchinger H, Rinder H, Martin K, Gardiner E, Lee A, Tang W, Hwa J. A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences. Nature Cardiovascular Research 2022, 1: 223-237. PMID: 37502132, PMCID: PMC10373053, DOI: 10.1038/s44161-022-00021-z.
- Jacobs JW, Gisriel SD, Iyer K, Rinder HM. Concomitant factor VIII inhibitor and lupus anticoagulant in an asymptomatic patient. Journal Of Thrombosis And Thrombolysis 2021, 53: 945-949. PMID: 34697688, PMCID: PMC8544916, DOI: 10.1007/s11239-021-02591-4.
- Gisriel S, Rinder H, Siddon A. Criteria for Ordering Myeloid Neoplasm Next-Generation Sequencing to Optimize Personalized Patient Care and Cost. Blood 2020, 136: 39-40. DOI: 10.1182/blood-2020-139035.
- Gupta G, Hendrickson J, Bahel P, Siddon A, Rinder H, Tormey C. Assessment of Factor V Activity in Apheresis Platelet Units: Implications for Management of FV Deficiency. American Journal Of Clinical Pathology 2020, 154: s6-s7. DOI: 10.1093/ajcp/aqaa137.011.
- Zanetto A, Rinder H, Deng Y, Ciarleglio M, Wilson F, Bulato C, Simioni P, Garcia-Tsao G. Acute kidney injury is associated with reversible platelet dysfunction in hospitalized patients with decompensated cirrhosis. Digestive And Liver Disease 2020, 52: e13. DOI: 10.1016/j.dld.2019.12.031.
- Chandler J, Bahel P, Siddon A, Torres R, Rinder H, Tormey C. A Modified Approach to Fibrinogen Replacement in the Setting of Dysfibrinogenemia. American Journal Of Clinical Pathology 2016, 146: 326. DOI: 10.1093/ajcp/aqw160.005.
- Tormey C, Rinder H. Platelet production and kinetics. 2016, 206-214. DOI: 10.1002/9781119013020.ch17.
- Schulz W, Durant T, Rinder H, Tormey C, Torres R, Smith B, Hager K, Howe J, Siddon A. Impact of Molecular Clonality on Survival in Acute Myeloid Leukemia. Blood 2015, 126: 1385. DOI: 10.1182/blood.v126.23.1385.1385.
- Siddon AJ, Rinder HM. Pathology Consultation on Evaluating Prognosis in Incidental Monoclonal Lymphocytosis and Chronic Lymphocytic Leukemia. American Journal Of Clinical Pathology 2013, 139: 708-712. PMID: 23690112, DOI: 10.1309/ajcplir4gzwx3xka.
- Perrotta P, Parsons J, Rinder H, Snyder E. Chapter 62 Platelet Transfusion Medicine. 2013, 1275-1303. DOI: 10.1016/b978-0-12-387837-3.00062-6.
- Smith B, Rinder H. Chapter 52 Cardiopulmonary Bypass. 2013, 1075-1096. DOI: 10.1016/b978-0-12-387837-3.00052-3.
- Streimish I, Bizzarro M, Northrup V, Wang C, Renna S, Koval N, Li FY, Ehrenkranz R, Rinder HM, Bhandari V. Neutrophil CD64 as a Diagnostic Marker in Neonatal Sepsis. The Pediatric Infectious Disease Journal 2012, 31: 777-781. PMID: 22481422, PMCID: PMC3375383, DOI: 10.1097/inf.0b013e318256fb07.
- Siddon AJ, Torres R, Rinder HM, Smith BR, Howe JG, Tormey CA. Normalized CCND1 expression has prognostic value in mantle cell lymphoma. British Journal Of Haematology 2012, 158: 551-553. PMID: 22671703, DOI: 10.1111/j.1365-2141.2012.09181.x.
- Hager K, Jennings K, Hosono S, Howell S, Gruen JR, Rivkees SA, Tartaglia NR, Rinder HM. Molecular diagnostic testing for Klinefelter syndrome and other male sex chromosome aneuploidies. International Journal Of Pediatric Endocrinology 2012, 2012: 8. PMID: 22524164, PMCID: PMC3411476, DOI: 10.1186/1687-9856-2012-8.
- Rinder HM, Grimes MM, Wagner J, Bennett BD. Senior Pathology Resident In-Service Examination Scores Correlate With Outcomes of the American Board of Pathology Certifying Examinations. American Journal Of Clinical Pathology 2011, 136: 499-506. PMID: 21917671, DOI: 10.1309/ajcpa7o4bbuglsww.
- Rivkees S, Hager K, Hosono S, Wise A, Li P, Rinder H, Gruen J. A Highly Sensitive, High-Throughput Assay for the Detection of Turner Syndrome. Obstetrical & Gynecological Survey 2011, 66: 421-422. DOI: 10.1097/ogx.0b013e3182338c32.
- Hematology in Clinical PracticeHillman RS, Ault KA, Leporrier M, Rinder HM editors. Hematology in Clinical Practice, Fifth Ed. McGraw-Hill, New York 2011
- Torres R, Rinder H. Chapter 54 Disorders of Hemostasis Thrombosis. 2010, 580-591. DOI: 10.1016/b978-1-4160-6109-0.00054-x.
- Rinder C, Rinder H. Chapter 52 Normal Hemostasis. 2010, 555-563. DOI: 10.1016/b978-1-4160-6109-0.00052-6.
- Rinder H, Tomer A. Platelet Production, Kinetics, and Hemostasis. 2009, 149-167. DOI: 10.1002/9781444303513.ch10.
- Smith B, Rinder H, Rinder C. Chapter 59 Cardiopulmonary bypass. 2007, 1077-1095. DOI: 10.1016/b978-012369367-9/50821-1.
- Kurup V, Transue S, Wu Y, Rinder HM, Barash P, Dewar M. Cardiac surgery in a patient with heparin-induced thrombocytopenia--cautions with use of the direct thrombin inhibitor, argatroban. Connecticut Medicine 2006, 70: 245-50. PMID: 16768071.
- Murphy S, Rinder H, Smith B. Utility of in vitro tests in predicting the in vivo viability of stored PLTs. Transfusion 2004, 44: 618-619. PMID: 15043581, DOI: 10.1111/j.1537-2995.2004.00355.x.
- Brouse C, Nguyen K, Greilich P, Rinder H, Jessen M, DiMaio J, Smith B, Eberhart R. “OFF-PUMP” CORONARY ARTERY BYPASS SURGERY REDUCES MONOCYTE-PLATELET CONJUGATE FORMATION. ASAIO Journal 2002, 48: 169. DOI: 10.1097/00002480-200203000-00179.
- Griffin M, Rinder H, Smith B, Tracey J, Kriz N, Li C, Rinder C. The Effects of Heparin, Protamine, and Heparin/Protamine Reversal on Platelet Function Under Conditions of Arterial Shear Stress. Anesthesia & Analgesia 2001, 93: 20-27. PMID: 11429331, DOI: 10.1097/00000539-200107000-00005.
- Rinder H, Gagnier R, Souhrada M, Wood C. SAT0063 Bleeding time and platelet function in normal volunteers receiving meloxicam. 2001, a173.1-a173. DOI: 10.1136/annrheumdis-2001.438.
- Perez L, Rinder H, Wang C, Tracey J, Maun N, Krause D. Xenotransplantation of immunodeficient mice with mobilized human blood CD34+ cells provides an in vivo model for human megakaryocytopoiesis and platelet production. Blood 2001, 97: 1635-1643. PMID: 11238102, DOI: 10.1182/blood.v97.6.1635.
- Margolin A, Avants S, Setaro J, Rinder H, Grupp L. Cocaine, HIV, and their cardiovascular effects: is there a role for ACE-inhibitor therapy? Drug And Alcohol Dependence 2000, 61: 35-45. PMID: 11064182, DOI: 10.1016/s0376-8716(00)00124-1.
- Pearson H, Ehrenkranz R, Rinder H, Riely C. Hemosiderosis in a Normal Child Secondary to Oral Iron Medication. Pediatrics 2000, 105: 429-430. PMID: 10654969, DOI: 10.1542/peds.105.2.429.
- Fitch J, Rollins S, Matis L, Alford B, Aranki S, Collard C, Dewar M, Elefteriades J, Hines R, Kopf G, Kraker P, Li L, O’Hara R, Rinder C, Rinder H, Shaw R, Smith B, Stahl G, Shernan S. Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass. Circulation 1999, 100: 2499-2506. PMID: 10604887, DOI: 10.1161/01.cir.100.25.2499.
- Rinder H, Arbini A, Snyder E. Optimal dosing and triggers for prophylactic use of platelet transfusions. Current Opinion In Hematology 1999, 6: 437. PMID: 10546800, DOI: 10.1097/00062752-199911000-00015.
- Rinder C, Rinder H, Johnson K, Smith M, Lee D, Tracey J, Polack G, Higgins P, Yeh C, Smith MD B. Role of C3 Cleavage in Monocyte Activation During Extracorporeal Circulation. Circulation 1999, 100: 553-558. PMID: 10430771, DOI: 10.1161/01.cir.100.5.553.
- Griffin M, Li C, Rinder H, Smith B, Rinder C. OPTIMAL HEPARIN-PROTAMINE REVERSAL RATIO. Anesthesia & Analgesia 1999, 88: 106sca.. DOI: 10.1097/00000539-199904001-00106.
- Mathew J, Fontes M, Phillips-Bute B, Rinder H, Herskowitz A, Smith B, Newman M, Rinder C. PLATELET ACTIVATION DURING CARDIOPULMONARY BYPASS PREDICTS POSTOPERATIVE NEUROCOGNITIVE DECLINE. Anesthesia & Analgesia 1999, 88: 109sca.. DOI: 10.1097/00000539-199904001-00109.
- Rinder H, Ault K. Platelet activation and its detection during the preparation of platelets for transfusion. Transfusion Medicine Reviews 1998, 12: 271-287. PMID: 9798270, DOI: 10.1016/s0887-7963(98)80003-5.
- Rollins S, Fitch J, Shernan S, Rinder C, Rinder H, Smith B, Collard C, Stahl G, Alford B, Li L, Matis L. Anti-C5 single chain antibody therapy blocks complement & leukocyte activation and reduces myocardial tissue damage in CPB patients. Molecular Immunology 1998, 35: 397. DOI: 10.1016/s0161-5890(98)90798-2.
- Varelas P, Sleight B, Rinder H, Sze G, Ment L. Stroke in a Neonate Heterozygous for Factor V Leiden. Pediatric Neurology 1998, 18: 262-264. PMID: 9568926, DOI: 10.1016/s0887-8994(97)00166-5.
- Rinder H, Schuster J, Rinder C, Wang C, Schweidler H, Smith B. Correlation of Thrombosis With Increased Platelet Turnover in Thrombocytosis. Blood 1998, 91: 1288-1294. PMID: 9454759, DOI: 10.1182/blood.v91.4.1288.
- Rinder H. Platelet function testing by flow cytometry. Clinical Laboratory Science 1998, 11: 365-72. PMID: 10345505.
- Grossman D, Heald P, Wang C, Rinder H. Activated protein C resistance and anticardiolipin antibodies in patients with venous leg ulcers. Journal Of The American Academy Of Dermatology 1997, 37: 409-413. DOI: 10.1016/s0190-9622(18)30738-2.
- Grossman D, Heald P, Wang C, Rinder H. Activated protein C resistance and anticardiolipin antibodies in patients with venous leg ulcers. Journal Of The American Academy Of Dermatology 1997, 37: 409-413. PMID: 9308555, DOI: 10.1016/s0190-9622(97)70141-5.
- Rinder C, Mathew J, Rinder H, Tracey J, Davis E, Smith B. Lymphocyte and monocyte subset changes during cardiopulmonary bypass: Effects of aging and gender. Translational Research 1997, 129: 592-602. PMID: 9178725, DOI: 10.1016/s0022-2143(97)90193-1.
- Rinder M, Richard R, Rinder H. Acquired von Willebrand's disease: A concise review. American Journal Of Hematology 1997, 54: 139-145. PMID: 9034288, DOI: 10.1002/(sici)1096-8652(199702)54:2<139::aid-ajh7>3.0.co;2-y.
- Tracey J, Rinder H. Characterization of the P-selectin ligand on human hematopoietic progenitors. Experimental Hematology 1996, 24: 1494-500. PMID: 8950232.
- HARRIS S, RINDER C, RINDER H, TRACEY J, SMITH B, HINES R. Nitroprusside Inhibition of Platelet Function Is Transient and Reversible by Catecholamine Priming. Survey Of Anesthesiology 1996, 40: 326. DOI: 10.1097/00132586-199610000-00069.
- Peterec S, Brennan S, Rinder H, Wnek J, Beardsley D. Reticulated platelet values in normal and thrombocytopenic neonates. The Journal Of Pediatrics 1996, 129: 269-274. PMID: 8765626, DOI: 10.1016/s0022-3476(96)70253-6.
- Harris S, Rinder C, Rinder H, Tracey J, Smith B, Hines R. Nitroprusside Inhibition of Platelet Function Is Transient and Reversible by Catecholamine Priming. Anesthesiology 1995, 83: 1145-1152.. PMID: 8533905, DOI: 10.1097/00000542-199512000-00003.
- Leitenberg D, Eisen R, Goldstein J, Busque L, Rinder H, Stys P, Katz M, Gilliland D, Smith B. Natural killer cell lymphoproliferative disease associated with neuropathy. The American Journal Of Medicine 1995, 99: 99-101. PMID: 7598151, DOI: 10.1016/s0002-9343(99)80112-0.
- Rinder H, Tracey J, Rinder C, Leitenberg D, Smith B. Neutrophil but not Monocyte Activation Inhibits P-Selectin-Mediated Platelet Adhesion*. Thrombosis And Haemostasis 1994, 72: 750-756. PMID: 7534948, DOI: 10.1055/s-0038-1648953.
- Rinder H, Bonan J, Anandan S, Rinder C, Rodrigues P, Smith B. Noninvasive measurement of platelet kinetics in normal and hypertensive pregnancies. American Journal Of Obstetrics And Gynecology 1994, 170: 117-122. DOI: 10.1016/s0002-9378(13)70291-6.
- Bonan J, Rinder H, Smith B. Determination of the percentage of thiazole orange (TO)‐positive, “reticulated” platelets using autologous erythrocyte TO fluorescence as an internal standard. Cytometry 1993, 14: 690-694. PMID: 8404376, DOI: 10.1002/cyto.990140615.
- Rinder C, Student L, Bonan J, Rinder H, Smith B. Aspirin Does Not Inhibit Adenosine Diphosphate-Induced Platelet α-Granule Release. Blood 1993, 82: 505-512. PMID: 7687162, DOI: 10.1182/blood.v82.2.505.505.
- Rinder C, Student L, Bonan J, Rinder H, Smith B. Aspirin does not inhibit adenosine diphosphate-induced platelet alpha- granule release. Blood 1993, 82: 505-512. DOI: 10.1182/blood.v82.2.505.bloodjournal822505.
- Ault K, Rinder H, Mitchell J, Carmody M, Vary C, Hillman R. The Significance of Platelets with Increased RNA Content (Reticulated Platelets) A Measure of the Rate of Thrombopoiesis. American Journal Of Clinical Pathology 1992, 98: 637-646. PMID: 1281383, DOI: 10.1093/ajcp/98.6.637.
- Rinder C, Bonan J, Rinder H, Mathew J, Hines R, Smith B. Cardiopulmonary Bypass Induces Leukocyte-Platelet Adhesion. Blood 1992, 79: 1201-1205. PMID: 1371416, DOI: 10.1182/blood.v79.5.1201.1201.
- Rinder C, Bonan J, Rinder H, Mathew J, Hines R, Smith B. Cardiopulmonary bypass induces leukocyte-platelet adhesion. Blood 1992, 79: 1201-1205. DOI: 10.1182/blood.v79.5.1201.bloodjournal7951201.
- Rinder H, Snyder E. Activation of platelet concentrate during preparation and storage. Blood Cells Molecules And Diseases 1992, 18: 445-56; discussion 457-60. PMID: 1283703.
- Rinder H, Bonan J, Rinder C, Ault K, Smith B. Activated and unactivated platelet adhesion to monocytes and neutrophils. Blood 1991, 78: 1760-9. PMID: 1717070, DOI: 10.1182/blood.v78.7.1760.bloodjournal7871760.
- Rinder H, Bonan J, Rinder C, Ault K, Smith B. Dynamics of leukocyte-platelet adhesion in whole blood. Blood 1991, 78: 1730-7. PMID: 1717069, DOI: 10.1182/blood.v78.7.1730.bloodjournal7871730.
- Rinder C, Mathew J, Rinder H, Bonan J, Ault K, Smith B. Modulation of Platelet Surface Adhesion Receptors during Cardiopulmonary Bypass. Anesthesiology 1991, 75: 563-570. PMID: 1718190, DOI: 10.1097/00000542-199110000-00004.
- Rinder H, Bonan J, Rinder C, Ault K, Smith B. Activated and Unactivated Platelet Adhesion to Monocytes and Neutrophils. Blood 1991, 78: 1760-1769. DOI: 10.1182/blood.v78.7.1760.1760.
- Rinder H, Bonan J, Rinder C, Ault K, Smith B. Dynamics of Leukocyte-Platelet Adhesion in Whole Blood. Blood 1991, 78: 1730-1737. DOI: 10.1182/blood.v78.7.1730.1730.
- Rinder C, Bohnert J, Rinder H, Mitchell J, Ault K, Hillman R. Platelet Activation and Aggregation during Cardiopulmonary Bypass. Anesthesiology 1991, 75: 388-393. PMID: 1716077, DOI: 10.1097/00000542-199109000-00002.
- Rinder H, Murphy M, Mitchell J, Stocks J, Ault K, Hillman R. Progressive platelet activation with storage: evidence for shortened survival of activated platelets after transfusion. Transfusion 1991, 31: 409-414. PMID: 1710840, DOI: 10.1046/j.1537-2995.1991.31591263195.x.
- Rinder C, Rinder H, Ault K, Smith B. A74 PLATELET RECEPTORS FOR ADHESIVE LIGANDS ARE DECREASED DURING CARDIOPULMONARY BYPASS. Anesthesiology 1990, 73: na. DOI: 10.1097/00000542-199009001-00074.
- Snyder E, Rinder H, Napychank P. In Vitro and In Vivo Evaluation of Platelet Transfusions Administered Through an Electromechanical Infusion Pump. American Journal Of Clinical Pathology 1990, 94: 77-80. PMID: 2360566, DOI: 10.1093/ajcp/94.1.77.
- Ault K, Rinder H, Mitchell J, Rinder C, Lambrew C, Hillman R. Correlated measurement of platelet release and aggregation in whole blood. Cytometry 1989, 10: 448-455. PMID: 2475308, DOI: 10.1002/cyto.990100413.
- RINDER C, D'AMATO S, RINDER H, COX P. Survival in complicated diphenhydramine overdose. Critical Care Medicine 1988, 16: 1161-1162. PMID: 3168512, DOI: 10.1097/00003246-198811000-00017.
- Rinder H, Murphy J, Higgins G. Impact of unusual gastrointestinal problems on the treatment of tricyclic antidepressant overdose. Annals Of Emergency Medicine 1988, 17: 1079-1081. PMID: 3177998, DOI: 10.1016/s0196-0644(88)80449-9.
- Bach M, Roediger J, Rinder H. Septic Anaerobic Jugular Phlebitis with Pulmonary Embolism: Problems in Management. Clinical Infectious Diseases 1988, 10: 424-427. PMID: 3375694, DOI: 10.1093/clinids/10.2.424.
- Rinder H, Rinder C. Cryptococcal meningitis and AIDS. Annals Of Emergency Medicine 1988, 17: 299. PMID: 3345031, DOI: 10.1016/s0196-0644(88)80148-3.
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