- Yale Medicine Fertility Center200 West Campus DriveFl 2Orange, CT 06477
Harvey Kliman, MD, PhD
Biography
Harvey J. Kliman, MD, PhD, is a research scientist who specializes in studying and treating infertility and pregnancy complications, including recurrent pregnancy loss. He is also the director of the Reproductive and Placental Research Unit at Yale School of Medicine.
“Much of my research focuses on the field of embryo implantation and what can go wrong in the process,” says Dr. Kliman, who developed the Endometrial Function Test®, which examines the uterine lining. “If the endometrium isn’t working correctly, a woman will not get pregnant.”
To use the test, a doctor takes a small sample of a woman’s endometrium (the mucous membrane lining the uterus) at two different times during her menstrual cycle. “The test tells us if we should give the patient more or less estrogen or progesterone before we transfer an embryo into her uterus,” Kliman explains. “Or sometimes we find inflammation, which we might need to treat.”
Dr. Kliman’s other research investigates pregnancy loss and recurrent pregnancy loss (the loss of two or more consecutive pregnancies). Dr. Kliman examines tissue samples from the placenta to understand why a loss happened.
“I will meet with the family and go through why they had their loss and what they can do the next time to hopefully prevent it,” he says. “Behind every healthy baby is a healthy placenta. The placenta is like the roots of a tree. The leaves and branches are the fetus. The tree trunk is the umbilical cord. If there aren't enough nutrients, if there's an infection, or if there's something developmentally wrong with that placenta, the roots don't grow normally and that can lead to problems.”
When it comes to working with families who have experienced pregnancy loss, Dr. Kliman says his first priority is to assure them it’s not their fault. “And if we can find a reason, we try to treat it,” he says. “I love helping patients. It’s amazing to help them overcome problems with implantation or a terrible loss, and see them achieve a successful pregnancy. I can't think of anything better,” he says.
Titles
- Research Scientist in Obstetrics, Gynecology, and Reproductive Sciences
- Director, Reproductive and Placental Research Unit
Education & Training
- FellowUniversity of Pennsylvania School of Medicine (1987)
- ResidentHospital of the University of Pennsylvania (1985)
- PhDUniversity of Chicago (1981)
- MDUniversity of Chicago (1980)
Additional Information
- AB of Pathology, Pathology, Anatomic/Clinical (1986)
- Yale University School of Medicine (2011 - 2015): Yale School of Medicine Admissions Committee
- Anam AK, Cooke KM, Dratver MB, O'Bryan JV, Perley LE, Guller SM, Hwang JJ, Taylor HS, Goedeke L, Kliman HJ, Vatner DF, Flannery CA. Insulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity. Molecular Metabolism 2022, 64: 101574. PMID: 35970449, PMCID: PMC9440306, DOI: 10.1016/j.molmet.2022.101574.
- Pinar H, Gordijn SJ, Grynspan D, Kingdom J, Roberts DJ, Kerzner L, Bates SV, Carreon CK, Leeman KT, Salafia C, Cohen M, Castro E, Ravishankar S, Kliman HJ, Dahlstrom J, Silver B, Heazell A. Pathologic Assessment of the Placenta: Evidence Compared With Tradition. Obstetrics And Gynecology 2022, 140: 341-342. PMID: 35852288, DOI: 10.1097/AOG.0000000000004883.
- Phung TN, Olney KC, Pinto BJ, Silasi M, Perley L, O'Bryan J, Kliman HJ, Wilson MA. X chromosome inactivation in the human placenta is patchy and distinct from adult tissues. HGG Advances 2022, 3: 100121. PMID: 35712697, PMCID: PMC9194956, DOI: 10.1016/j.xhgg.2022.100121.
- Firestein MR, Kliman HJ, Sania A, Brink LT, Holzer PH, Hofmann KM, Milano KM, Pini N, Shuffrey LC, Odendaal HJ, Fifer WP. Trophoblast inclusions and adverse birth outcomes. PloS One 2022, 17: e0264733. PMID: 35231069, PMCID: PMC8887719, DOI: 10.1371/journal.pone.0264733.
- Tal R, Kisa J, Abuwala N, Kliman HJ, Shaikh S, Chen AY, Lyu F, Taylor HS. Bone marrow-derived progenitor cells contribute to remodeling of the postpartum uterus. Stem Cells (Dayton, Ohio) 2021, 39: 1489-1505. PMID: 34224633, PMCID: PMC9313624, DOI: 10.1002/stem.3431.
- Katz J, Holzer PH, Kliman HJ. Genetics, not the uterine environment, drive the formation of trophoblast inclusions: Insights from a twin study. Placenta 2021, 114: 133-138. PMID: 33941390, DOI: 10.1016/j.placenta.2021.04.010.
- Feliciano D, Ott CM, Espinosa-Medina I, Weigel AV, Benedetti L, Milano KM, Tang Z, Lee T, Kliman HJ, Guller SM, Lippincott-Schwartz J. YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion. Nature Communications 2021, 12: 4502. PMID: 34301937, PMCID: PMC8302681, DOI: 10.1038/s41467-021-24708-2.
- Tal A, Tal R, Kliman HJ, Taylor HS. Loss of Cxcr4 in Endometriosis Reduces Proliferation and Lesion Number while Increasing Intraepithelial Lymphocyte Infiltration. The American Journal Of Pathology 2021, 191: 1292-1302. PMID: 33964217, PMCID: PMC8261475, DOI: 10.1016/j.ajpath.2021.04.011.
- Lu-Culligan A, Chavan AR, Vijayakumar P, Irshaid L, Courchaine EM, Milano KM, Tang Z, Pope SD, Song E, Vogels CBF, Lu-Culligan WJ, Campbell KH, Casanovas-Massana A, Bermejo S, Toothaker JM, Lee HJ, Liu F, Schulz W, Fournier J, Muenker MC, Moore AJ, Konnikova L, Neugebauer KM, Ring A, Grubaugh ND, Ko AI, Morotti R, Guller S, Kliman HJ, Iwasaki A, Farhadian SF. Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface. Med (New York, N.Y.) 2021, 2: 591-610.e10. PMID: 33969332, PMCID: PMC8084634, DOI: 10.1016/j.medj.2021.04.016.
- Lu-Culligan A, Chavan AR, Vijayakumar P, Irshaid L, Courchaine EM, Milano KM, Tang Z, Pope SD, Song E, Vogels CBF, Lu-Culligan WJ, Campbell KH, Casanovas-Massana A, Bermejo S, Toothaker JM, Lee HJ, Liu F, Schulz W, Fournier J, Muenker MC, Moore AJ, Konnikova L, Neugebauer KM, Ring A, Grubaugh ND, Ko AI, Morotti R, Guller S, Kliman HJ, Iwasaki A, Farhadian SF. SARS-CoV-2 infection in pregnancy is associated with robust inflammatory response at the maternal-fetal interface. MedRxiv : The Preprint Server For Health Sciences 2021 PMID: 33532791, PMCID: PMC7852242, DOI: 10.1101/2021.01.25.21250452.
- Kliman HJ, Firestein MR, Hofmann KM, Milano KM, Holzer PH, Brink LT, Odendaal HJ, Fifer WP. Trophoblast inclusions in the human placenta: Identification, characterization, quantification, and interrelations of subtypes. Placenta 2021, 103: 172-176. PMID: 33152642, PMCID: PMC8448462, DOI: 10.1016/j.placenta.2020.10.014.
- Kliman HJ. Noyes, Hertig, and Rock revisited. F&S Reports 2020, 1: 2-4. PMID: 34223203, PMCID: PMC8244307, DOI: 10.1016/j.xfre.2020.04.004.
- Pavlicev M, Zupan AM, Barry A, Walters S, Milano KM, Kliman HJ, Wagner GP. An experimental test of the ovulatory homolog model of female orgasm. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 20267-20273. PMID: 31570579, PMCID: PMC6789565, DOI: 10.1073/pnas.1910295116.
- Kliman HJ, Frankfurter D. Clinical approach to recurrent implantation failure: evidence-based evaluation of the endometrium. Fertility And Sterility 2019, 111: 618-628. PMID: 30929719, DOI: 10.1016/j.fertnstert.2019.02.011.
- Isakov KMM, Emerson JW, Campbell KH, Galerneau F, Anders AM, Lee YK, Subramanyam P, Roberts AE, Kliman HJ. Estimated Placental Volume and Gestational Age. American Journal Of Perinatology 2018, 35: 748-757. PMID: 29281842, DOI: 10.1055/s-0037-1615285.
- Kliman HJ, Quaratella SB, Setaro AC, Siegman EC, Subha ZT, Tal R, Milano KM, Steck TL. Pathway of Maternal Serotonin to the Human Embryo and Fetus. Endocrinology 2018, 159: 1609-1629. PMID: 29381782, DOI: 10.1210/en.2017-03025.
- Salvante KG, Milano K, Kliman HJ, Nepomnaschy PA. Placental 11 β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) expression very early during human pregnancy. Journal Of Developmental Origins Of Health And Disease 2017, 8: 149-154. PMID: 28112069, DOI: 10.1017/S2040174416000611.
- Stephenson MD, McQueen D, Winter M, Kliman HJ. Luteal start vaginal micronized progesterone improves pregnancy success in women with recurrent pregnancy loss. Fertility And Sterility 2017, 107: 684-690.e2. PMID: 28081870, DOI: 10.1016/j.fertnstert.2016.11.029.
- Kliman HJ. Comment on "the placenta harbors a unique microbiome". Science Translational Medicine 2014, 6: 254le4. PMID: 25232175, DOI: 10.1126/scitranslmed.3009864.
- Arleo EK, Troiano RN, da Silva R, Greenbaum D, Kliman HJ. Utilizing two-dimensional ultrasound to develop normative curves for estimated placental volume. American Journal Of Perinatology 2014, 31: 683-8. PMID: 24108663, DOI: 10.1055/s-0033-1357265.
- Walker CK, Anderson KW, Milano KM, Ye S, Tancredi DJ, Pessah IN, Hertz-Picciotto I, Kliman HJ. Trophoblast inclusions are significantly increased in the placentas of children in families at risk for autism. Biological Psychiatry 2013, 74: 204-11. PMID: 23623455, PMCID: PMC3755347, DOI: 10.1016/j.biopsych.2013.03.006.
- Kliman HJ, Sammar M, Grimpel YI, Lynch SK, Milano KM, Pick E, Bejar J, Arad A, Lee JJ, Meiri H, Gonen R. Placental protein 13 and decidual zones of necrosis: an immunologic diversion that may be linked to preeclampsia. Reproductive Sciences (Thousand Oaks, Calif.) 2012, 19: 16-30. PMID: 21989657, DOI: 10.1177/1933719111424445.
- Azpurua H, Funai EF, Coraluzzi LM, Doherty LF, Sasson IE, Kliman M, Kliman HJ. Determination of placental weight using two-dimensional sonography and volumetric mathematic modeling. American Journal Of Perinatology 2010, 27: 151-5. PMID: 19653142, DOI: 10.1055/s-0029-1234034.
- Lash GE, Ansari T, Bischof P, Burton GJ, Chamley L, Crocker I, Dantzer V, Desoye G, Drewlo S, Fazleabas A, Jansson T, Keating S, Kliman HJ, Lang I, Mayhew T, Meiri H, Miller RK, Nelson DM, Pfarrer C, Roberts C, Sammar M, Sharma S, Shiverick K, Strunk D, Turner MA, Huppertz B. IFPA meeting 2008 workshops report. Placenta 2009, 30 Suppl A: S4-14. PMID: 19084270, PMCID: PMC2668143, DOI: 10.1016/j.placenta.2008.11.014.
- Funai EF, Labowsky AT, Drewes CE, Kliman HJ. Timing of fetal meconium absorption by amnionic macrophages. American Journal Of Perinatology 2009, 26: 93-7. PMID: 19031358, DOI: 10.1055/s-0028-1103028.
- Yusuf K, Kliman HJ. The fetus, not the mother, elicits maternal immunologic rejection: lessons from discordant dizygotic twin placentas. Journal Of Perinatal Medicine 2008, 36: 291-6. PMID: 18598117, DOI: 10.1515/JPM.2008.054.
- Hecht JL, Kliman HJ, Allred EN, Pflueger SM, Chang CH, Doss BJ, Roberts D, Livasy CA, Bhan I, Zambrano E, Ross DW, Senagore P, Husain AN, Leviton A. Reference weights for placentas delivered before the 28th week of gestation. Placenta 2007, 28: 987-90. PMID: 17573110, DOI: 10.1016/j.placenta.2007.04.009.
- Anderson GM, Jacobs-Stannard A, Chawarska K, Volkmar FR, Kliman HJ. Placental trophoblast inclusions in autism spectrum disorder. Biological Psychiatry 2007, 61: 487-91. PMID: 16806106, DOI: 10.1016/j.biopsych.2006.03.068.
- Kliman HJ, Honig S, Walls D, Luna M, McSweet JC, Copperman AB. Optimization of endometrial preparation results in a normal endometrial function test (EFT) and good reproductive outcome in donor ovum recipients. Journal Of Assisted Reproduction And Genetics 2006, 23: 299-303. PMID: 16983518, DOI: 10.1007/s10815-006-9061-1.
- Catalanotti JS, Spandorfer SD, Barmat LI, Rosenwaks Z, McSweet JC, Kliman HJ. Mouse ascites Golgi mucin expression abnormalities in natural cycle endometrial biopsies predict subsequent in vitro fertilization-embryo transfer (IVF-ET) failure in patients with previous IVF-ET failures. Fertility And Sterility 2006, 85: 255-8. PMID: 16412771, DOI: 10.1016/j.fertnstert.2005.06.060.
- Kliman HJ, Segel L. The placenta may predict the baby. Journal Of Theoretical Biology 2003, 225: 143-5. PMID: 14559066, DOI: 10.1016/s0022-5193(03)00248-0.
- Dubowy RL, Feinberg RF, Keefe DL, Doncel GF, Williams SC, McSweet JC, Kliman HJ. Improved endometrial assessment using cyclin E and p27. Fertility And Sterility 2003, 80: 146-56. PMID: 12849817, DOI: 10.1016/s0015-0282(03)00573-9.
- Meaddough EL, Olive DL, Gallup P, Perlin M, Kliman HJ. Sexual activity, orgasm and tampon use are associated with a decreased risk for endometriosis. Gynecologic And Obstetric Investigation 2002, 53: 163-9. PMID: 12053101, DOI: 10.1159/000058368.
- Schwartz LB, Naftolin F, Lyttle CR, Penzias AS, Meaddough EL, Kliman HJ. Mouse ascites golgi (MAG) mucin expression and regulation by progesterone in the rat uterus. Journal Of The Society For Gynecologic Investigation 2001, 8: 216-23. PMID: 11525897, DOI: 10.1016/s1071-5576(01)00115-0.
- Kliman HJ. Uteroplacental blood flow. The story of decidualization, menstruation, and trophoblast invasion. The American Journal Of Pathology 2000, 157: 1759-68. PMID: 11106547, PMCID: PMC1885765, DOI: 10.1016/S0002-9440(10)64813-4.
- Acosta AA, Elberger L, Borghi M, Calamera JC, Chemes H, Doncel GF, Kliman H, Lema B, Lustig L, Papier S. Endometrial dating and determination of the window of implantation in healthy fertile women. Fertility And Sterility 2000, 73: 788-98. PMID: 10731542, DOI: 10.1016/s0015-0282(99)00605-6.
- Keltz MD, Attar E, Buradagunta S, Olive DL, Kliman HJ, Arici A. Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in the human fallopian tube. American Journal Of Obstetrics And Gynecology 1996, 175: 1611-9. PMID: 8987949, DOI: 10.1016/s0002-9378(96)70114-x.
- Nachtigall MJ, Kliman HJ, Feinberg RF, Olive DL, Engin O, Arici A. The effect of leukemia inhibitory factor (LIF) on trophoblast differentiation: a potential role in human implantation. The Journal Of Clinical Endocrinology And Metabolism 1996, 81: 801-6. PMID: 8636307, DOI: 10.1210/jcem.81.2.8636307.
- Arici A, Tazuke SI, Attar E, Kliman HJ, Olive DL. Interleukin-8 concentration in peritoneal fluid of patients with endometriosis and modulation of interleukin-8 expression in human mesothelial cells. Molecular Human Reproduction 1996, 2: 40-5. PMID: 9238656, DOI: 10.1093/molehr/2.1.40.
- Kliman HJ, Perrotta PL, Jones DC. The efficacy of the placental biopsy. American Journal Of Obstetrics And Gynecology 1995, 173: 1084-8. PMID: 7485298, DOI: 10.1016/0002-9378(95)91331-9.
- Keltz MD, Kliman HJ, Arici AM, Olive DL. Endosalpingiosis found at laparoscopy for chronic pelvic pain. Fertility And Sterility 1995, 64: 482-5. PMID: 7641898.
- Feinberg RF, Kliman HJ, Bedian V, Monzon-Bordonaba F, Menzin AW, Wang CL. Monoclonal antibody X18A4 identifies an oncofetal fibronectin epitope distinct from the FDC-6 binding site. American Journal Of Obstetrics And Gynecology 1995, 172: 1526-36. PMID: 7538728, DOI: 10.1016/0002-9378(95)90491-3.
- Bahado-Singh RO, Kliman H, Feng TY, Hobbins J, Copel JA, Mahoney MJ. First-trimester endocervical irrigation: feasibility of obtaining trophoblast cells for prenatal diagnosis. Obstetrics And Gynecology 1995, 85: 461-4. PMID: 7862393, DOI: 10.1016/0029-7844(94)00416-b.
- Kliman HJ, Feinberg RF, Schwartz LB, Feinman MA, Lavi E, Meaddough EL. A mucin-like glycoprotein identified by MAG (mouse ascites Golgi) antibodies. Menstrual cycle-dependent localization in human endometrium. The American Journal Of Pathology 1995, 146: 166-81. PMID: 7531946, PMCID: PMC1870765.
- Rotmensch S, Liberati M, Luo JS, Kliman HJ, Gollin Y, Bellati U, Hobbins JC, Copel JA. Color Doppler flow patterns and flow velocity waveforms of the intraplacental fetal circulation in growth-retarded fetuses. American Journal Of Obstetrics And Gynecology 1994, 171: 1257-64. PMID: 7977530, DOI: 10.1016/0002-9378(94)90143-0.
- Feinberg RF, Kliman HJ, Wang CL. Transforming growth factor-beta stimulates trophoblast oncofetal fibronectin synthesis in vitro: implications for trophoblast implantation in vivo. The Journal Of Clinical Endocrinology And Metabolism 1994, 78: 1241-8. PMID: 8175984, DOI: 10.1210/jcem.78.5.8175984.
- Kliman HJ. The placenta revealed. The American Journal Of Pathology 1993, 143: 332-6. PMID: 8342590, PMCID: PMC1887036.
- Feinberg RF, Kliman HJ. Fetal fibronectin and preterm labor. The New England Journal Of Medicine 1992, 326: 708; author reply 709. PMID: 1736115, DOI: 10.1056/NEJM199203053261013.
- Feinberg RF, Kliman HJ, Cohen AW. Preeclampsia, trisomy 13, and the placental bed. Obstetrics And Gynecology 1991, 78: 505-8. PMID: 1870809.
- Lavi E, Montone KT, Rorke LB, Kliman HJ. Fetal akinesia deformation sequence (Pena-Shokeir phenotype) associated with acquired intrauterine brain damage. Neurology 1991, 41: 1467-8. PMID: 1891100, DOI: 10.1212/wnl.41.9.1467.
- Feinberg RF, Kliman HJ, Lockwood CJ. Is oncofetal fibronectin a trophoblast glue for human implantation? The American Journal Of Pathology 1991, 138: 537-43. PMID: 2000933, PMCID: PMC1886265.
- Coutifaris C, Babalola GO, Abisogun AO, Kao LC, Chin U, Vadillo-Ortega F, Osheroff J, Kliman HJ, Strauss JF. In vitro systems for the study of human trophoblast implantation. Annals Of The New York Academy Of Sciences 1991, 622: 191-201. PMID: 2064180, DOI: 10.1111/j.1749-6632.1991.tb37862.x.
- Kliman HJ, Feinberg RF, Haimowitz JE. Human trophoblast-endometrial interactions in an in vitro suspension culture system. Placenta 1990, 11: 349-67. PMID: 2235916, DOI: 10.1016/s0143-4004(05)80226-7.
- Kliman HJ, Feinberg RF. Human trophoblast-extracellular matrix (ECM) interactions in vitro: ECM thickness modulates morphology and proteolytic activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1990, 87: 3057-61. PMID: 2326266, PMCID: PMC53833, DOI: 10.1073/pnas.87.8.3057.
- Babalola GO, Coutifaris C, Soto EA, Kliman HJ, Shuman H, Strauss JF. Aggregation of dispersed human cytotrophoblastic cells: lessons relevant to the morphogenesis of the placenta. Developmental Biology 1990, 137: 100-8. PMID: 2295358, DOI: 10.1016/0012-1606(90)90011-7.
- Feinberg RF, Kao LC, Haimowitz JE, Queenan JT, Wun TC, Strauss JF, Kliman HJ. Plasminogen activator inhibitor types 1 and 2 in human trophoblasts. PAI-1 is an immunocytochemical marker of invading trophoblasts. Laboratory Investigation; A Journal Of Technical Methods And Pathology 1989, 61: 20-6. PMID: 2473276.
- Nulsen JC, Silavin SL, Kao LC, Ringler GE, Kliman HJ, Strauss JF. Control of the steroidogenic machinery of the human trophoblast by cyclic AMP. Journal Of Reproduction And Fertility. Supplement 1989, 37: 147-53. PMID: 2553955.
- Kliman HJ, Coutifaris C, Babalola GO, Soto EA, Kao LC, Queenan JT, Feinberg RF, Strauss JF. The human trophoblast: homotypic and heterotypic cell-cell interactions. Progress In Clinical And Biological Research 1989, 294: 425-34. PMID: 2726976.
- Kao LC, Caltabiano S, Wu S, Strauss JF, Kliman HJ. The human villous cytotrophoblast: interactions with extracellular matrix proteins, endocrine function, and cytoplasmic differentiation in the absence of syncytium formation. Developmental Biology 1988, 130: 693-702. PMID: 2848742, DOI: 10.1016/0012-1606(88)90361-2.
- Roy-Choudhury S, Sen-Majumdar A, Murthy U, Mishra VS, Kliman HJ, Nestler JE, Strauss JF, Das M. Biosynthesis and turnover of a 34-kDa protein growth factor in human cytotrophoblasts. European Journal Of Biochemistry / FEBS 1988, 172: 777-83. PMID: 3350024, DOI: 10.1111/j.1432-1033.1988.tb13957.x.
- Feinman MA, Kliman HJ, Main EK. HLA antigen expression and induction by gamma-interferon in cultured human trophoblasts. American Journal Of Obstetrics And Gynecology 1987, 157: 1429-34. PMID: 3122576, DOI: 10.1016/s0002-9378(87)80238-7.
- Ulloa-Aguirre A, August AM, Golos TG, Kao LC, Sakuragi N, Kliman HJ, Strauss JF. 8-Bromo-adenosine 3',5'-monophosphate regulates expression of chorionic gonadotropin and fibronectin in human cytotrophoblasts. The Journal Of Clinical Endocrinology And Metabolism 1987, 64: 1002-9. PMID: 2435752, DOI: 10.1210/jcem-64-5-1002.
- Feinman MA, Kliman HJ, Caltabiano S, Strauss JF. 8-Bromo-3',5'-adenosine monophosphate stimulates the endocrine activity of human cytotrophoblasts in culture. The Journal Of Clinical Endocrinology And Metabolism 1986, 63: 1211-7. PMID: 3531221, DOI: 10.1210/jcem-63-5-1211.
- Kliman HJ, Nestler JE, Sermasi E, Sanger JM, Strauss JF. Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae. Endocrinology 1986, 118: 1567-82. PMID: 3512258, DOI: 10.1210/endo-118-4-1567.
- Soto EA, Kliman HJ, Strauss JF, Paavola LG. Gonadotropins and cyclic adenosine 3',5'-monophosphate (cAMP) alter the morphology of cultured human granulosa cells. Biology Of Reproduction 1986, 34: 559-69. PMID: 3008869, DOI: 10.1095/biolreprod34.3.559.
- Ballas SK, Kliman HJ, Smith ED. Glyceraldehyde-3-phosphate dehydrogenase of rat erythrocytes has no membrane component. Biochimica Et Biophysica Acta 1985, 831: 142-9. PMID: 4041465, DOI: 10.1016/0167-4838(85)90161-x.
- Kliman HJ, Steck TL. Association of glyceraldehyde-3-phosphate dehydrogenase with the human red cell membrane. A kinetic analysis. The Journal Of Biological Chemistry 1980, 255: 6314-21. PMID: 7391020.
Biography
Harvey J. Kliman, MD, PhD, is a research scientist who specializes in studying and treating infertility and pregnancy complications, including recurrent pregnancy loss. He is also the director of the Reproductive and Placental Research Unit at Yale School of Medicine.
“Much of my research focuses on the field of embryo implantation and what can go wrong in the process,” says Dr. Kliman, who developed the Endometrial Function Test®, which examines the uterine lining. “If the endometrium isn’t working correctly, a woman will not get pregnant.”
To use the test, a doctor takes a small sample of a woman’s endometrium (the mucous membrane lining the uterus) at two different times during her menstrual cycle. “The test tells us if we should give the patient more or less estrogen or progesterone before we transfer an embryo into her uterus,” Kliman explains. “Or sometimes we find inflammation, which we might need to treat.”
Dr. Kliman’s other research investigates pregnancy loss and recurrent pregnancy loss (the loss of two or more consecutive pregnancies). Dr. Kliman examines tissue samples from the placenta to understand why a loss happened.
“I will meet with the family and go through why they had their loss and what they can do the next time to hopefully prevent it,” he says. “Behind every healthy baby is a healthy placenta. The placenta is like the roots of a tree. The leaves and branches are the fetus. The tree trunk is the umbilical cord. If there aren't enough nutrients, if there's an infection, or if there's something developmentally wrong with that placenta, the roots don't grow normally and that can lead to problems.”
When it comes to working with families who have experienced pregnancy loss, Dr. Kliman says his first priority is to assure them it’s not their fault. “And if we can find a reason, we try to treat it,” he says. “I love helping patients. It’s amazing to help them overcome problems with implantation or a terrible loss, and see them achieve a successful pregnancy. I can't think of anything better,” he says.
Titles
- Research Scientist in Obstetrics, Gynecology, and Reproductive Sciences
- Director, Reproductive and Placental Research Unit
Education & Training
- FellowUniversity of Pennsylvania School of Medicine (1987)
- ResidentHospital of the University of Pennsylvania (1985)
- PhDUniversity of Chicago (1981)
- MDUniversity of Chicago (1980)
Additional Information
- AB of Pathology, Pathology, Anatomic/Clinical (1986)
- Yale University School of Medicine (2011 - 2015): Yale School of Medicine Admissions Committee
- Anam AK, Cooke KM, Dratver MB, O'Bryan JV, Perley LE, Guller SM, Hwang JJ, Taylor HS, Goedeke L, Kliman HJ, Vatner DF, Flannery CA. Insulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity. Molecular Metabolism 2022, 64: 101574. PMID: 35970449, PMCID: PMC9440306, DOI: 10.1016/j.molmet.2022.101574.
- Pinar H, Gordijn SJ, Grynspan D, Kingdom J, Roberts DJ, Kerzner L, Bates SV, Carreon CK, Leeman KT, Salafia C, Cohen M, Castro E, Ravishankar S, Kliman HJ, Dahlstrom J, Silver B, Heazell A. Pathologic Assessment of the Placenta: Evidence Compared With Tradition. Obstetrics And Gynecology 2022, 140: 341-342. PMID: 35852288, DOI: 10.1097/AOG.0000000000004883.
- Phung TN, Olney KC, Pinto BJ, Silasi M, Perley L, O'Bryan J, Kliman HJ, Wilson MA. X chromosome inactivation in the human placenta is patchy and distinct from adult tissues. HGG Advances 2022, 3: 100121. PMID: 35712697, PMCID: PMC9194956, DOI: 10.1016/j.xhgg.2022.100121.
- Firestein MR, Kliman HJ, Sania A, Brink LT, Holzer PH, Hofmann KM, Milano KM, Pini N, Shuffrey LC, Odendaal HJ, Fifer WP. Trophoblast inclusions and adverse birth outcomes. PloS One 2022, 17: e0264733. PMID: 35231069, PMCID: PMC8887719, DOI: 10.1371/journal.pone.0264733.
- Tal R, Kisa J, Abuwala N, Kliman HJ, Shaikh S, Chen AY, Lyu F, Taylor HS. Bone marrow-derived progenitor cells contribute to remodeling of the postpartum uterus. Stem Cells (Dayton, Ohio) 2021, 39: 1489-1505. PMID: 34224633, PMCID: PMC9313624, DOI: 10.1002/stem.3431.
- Katz J, Holzer PH, Kliman HJ. Genetics, not the uterine environment, drive the formation of trophoblast inclusions: Insights from a twin study. Placenta 2021, 114: 133-138. PMID: 33941390, DOI: 10.1016/j.placenta.2021.04.010.
- Feliciano D, Ott CM, Espinosa-Medina I, Weigel AV, Benedetti L, Milano KM, Tang Z, Lee T, Kliman HJ, Guller SM, Lippincott-Schwartz J. YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion. Nature Communications 2021, 12: 4502. PMID: 34301937, PMCID: PMC8302681, DOI: 10.1038/s41467-021-24708-2.
- Tal A, Tal R, Kliman HJ, Taylor HS. Loss of Cxcr4 in Endometriosis Reduces Proliferation and Lesion Number while Increasing Intraepithelial Lymphocyte Infiltration. The American Journal Of Pathology 2021, 191: 1292-1302. PMID: 33964217, PMCID: PMC8261475, DOI: 10.1016/j.ajpath.2021.04.011.
- Lu-Culligan A, Chavan AR, Vijayakumar P, Irshaid L, Courchaine EM, Milano KM, Tang Z, Pope SD, Song E, Vogels CBF, Lu-Culligan WJ, Campbell KH, Casanovas-Massana A, Bermejo S, Toothaker JM, Lee HJ, Liu F, Schulz W, Fournier J, Muenker MC, Moore AJ, Konnikova L, Neugebauer KM, Ring A, Grubaugh ND, Ko AI, Morotti R, Guller S, Kliman HJ, Iwasaki A, Farhadian SF. Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface. Med (New York, N.Y.) 2021, 2: 591-610.e10. PMID: 33969332, PMCID: PMC8084634, DOI: 10.1016/j.medj.2021.04.016.
- Lu-Culligan A, Chavan AR, Vijayakumar P, Irshaid L, Courchaine EM, Milano KM, Tang Z, Pope SD, Song E, Vogels CBF, Lu-Culligan WJ, Campbell KH, Casanovas-Massana A, Bermejo S, Toothaker JM, Lee HJ, Liu F, Schulz W, Fournier J, Muenker MC, Moore AJ, Konnikova L, Neugebauer KM, Ring A, Grubaugh ND, Ko AI, Morotti R, Guller S, Kliman HJ, Iwasaki A, Farhadian SF. SARS-CoV-2 infection in pregnancy is associated with robust inflammatory response at the maternal-fetal interface. MedRxiv : The Preprint Server For Health Sciences 2021 PMID: 33532791, PMCID: PMC7852242, DOI: 10.1101/2021.01.25.21250452.
- Kliman HJ, Firestein MR, Hofmann KM, Milano KM, Holzer PH, Brink LT, Odendaal HJ, Fifer WP. Trophoblast inclusions in the human placenta: Identification, characterization, quantification, and interrelations of subtypes. Placenta 2021, 103: 172-176. PMID: 33152642, PMCID: PMC8448462, DOI: 10.1016/j.placenta.2020.10.014.
- Kliman HJ. Noyes, Hertig, and Rock revisited. F&S Reports 2020, 1: 2-4. PMID: 34223203, PMCID: PMC8244307, DOI: 10.1016/j.xfre.2020.04.004.
- Pavlicev M, Zupan AM, Barry A, Walters S, Milano KM, Kliman HJ, Wagner GP. An experimental test of the ovulatory homolog model of female orgasm. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 20267-20273. PMID: 31570579, PMCID: PMC6789565, DOI: 10.1073/pnas.1910295116.
- Kliman HJ, Frankfurter D. Clinical approach to recurrent implantation failure: evidence-based evaluation of the endometrium. Fertility And Sterility 2019, 111: 618-628. PMID: 30929719, DOI: 10.1016/j.fertnstert.2019.02.011.
- Isakov KMM, Emerson JW, Campbell KH, Galerneau F, Anders AM, Lee YK, Subramanyam P, Roberts AE, Kliman HJ. Estimated Placental Volume and Gestational Age. American Journal Of Perinatology 2018, 35: 748-757. PMID: 29281842, DOI: 10.1055/s-0037-1615285.
- Kliman HJ, Quaratella SB, Setaro AC, Siegman EC, Subha ZT, Tal R, Milano KM, Steck TL. Pathway of Maternal Serotonin to the Human Embryo and Fetus. Endocrinology 2018, 159: 1609-1629. PMID: 29381782, DOI: 10.1210/en.2017-03025.
- Salvante KG, Milano K, Kliman HJ, Nepomnaschy PA. Placental 11 β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) expression very early during human pregnancy. Journal Of Developmental Origins Of Health And Disease 2017, 8: 149-154. PMID: 28112069, DOI: 10.1017/S2040174416000611.
- Stephenson MD, McQueen D, Winter M, Kliman HJ. Luteal start vaginal micronized progesterone improves pregnancy success in women with recurrent pregnancy loss. Fertility And Sterility 2017, 107: 684-690.e2. PMID: 28081870, DOI: 10.1016/j.fertnstert.2016.11.029.
- Kliman HJ. Comment on "the placenta harbors a unique microbiome". Science Translational Medicine 2014, 6: 254le4. PMID: 25232175, DOI: 10.1126/scitranslmed.3009864.
- Arleo EK, Troiano RN, da Silva R, Greenbaum D, Kliman HJ. Utilizing two-dimensional ultrasound to develop normative curves for estimated placental volume. American Journal Of Perinatology 2014, 31: 683-8. PMID: 24108663, DOI: 10.1055/s-0033-1357265.
- Walker CK, Anderson KW, Milano KM, Ye S, Tancredi DJ, Pessah IN, Hertz-Picciotto I, Kliman HJ. Trophoblast inclusions are significantly increased in the placentas of children in families at risk for autism. Biological Psychiatry 2013, 74: 204-11. PMID: 23623455, PMCID: PMC3755347, DOI: 10.1016/j.biopsych.2013.03.006.
- Kliman HJ, Sammar M, Grimpel YI, Lynch SK, Milano KM, Pick E, Bejar J, Arad A, Lee JJ, Meiri H, Gonen R. Placental protein 13 and decidual zones of necrosis: an immunologic diversion that may be linked to preeclampsia. Reproductive Sciences (Thousand Oaks, Calif.) 2012, 19: 16-30. PMID: 21989657, DOI: 10.1177/1933719111424445.
- Azpurua H, Funai EF, Coraluzzi LM, Doherty LF, Sasson IE, Kliman M, Kliman HJ. Determination of placental weight using two-dimensional sonography and volumetric mathematic modeling. American Journal Of Perinatology 2010, 27: 151-5. PMID: 19653142, DOI: 10.1055/s-0029-1234034.
- Lash GE, Ansari T, Bischof P, Burton GJ, Chamley L, Crocker I, Dantzer V, Desoye G, Drewlo S, Fazleabas A, Jansson T, Keating S, Kliman HJ, Lang I, Mayhew T, Meiri H, Miller RK, Nelson DM, Pfarrer C, Roberts C, Sammar M, Sharma S, Shiverick K, Strunk D, Turner MA, Huppertz B. IFPA meeting 2008 workshops report. Placenta 2009, 30 Suppl A: S4-14. PMID: 19084270, PMCID: PMC2668143, DOI: 10.1016/j.placenta.2008.11.014.
- Funai EF, Labowsky AT, Drewes CE, Kliman HJ. Timing of fetal meconium absorption by amnionic macrophages. American Journal Of Perinatology 2009, 26: 93-7. PMID: 19031358, DOI: 10.1055/s-0028-1103028.
- Yusuf K, Kliman HJ. The fetus, not the mother, elicits maternal immunologic rejection: lessons from discordant dizygotic twin placentas. Journal Of Perinatal Medicine 2008, 36: 291-6. PMID: 18598117, DOI: 10.1515/JPM.2008.054.
- Hecht JL, Kliman HJ, Allred EN, Pflueger SM, Chang CH, Doss BJ, Roberts D, Livasy CA, Bhan I, Zambrano E, Ross DW, Senagore P, Husain AN, Leviton A. Reference weights for placentas delivered before the 28th week of gestation. Placenta 2007, 28: 987-90. PMID: 17573110, DOI: 10.1016/j.placenta.2007.04.009.
- Anderson GM, Jacobs-Stannard A, Chawarska K, Volkmar FR, Kliman HJ. Placental trophoblast inclusions in autism spectrum disorder. Biological Psychiatry 2007, 61: 487-91. PMID: 16806106, DOI: 10.1016/j.biopsych.2006.03.068.
- Kliman HJ, Honig S, Walls D, Luna M, McSweet JC, Copperman AB. Optimization of endometrial preparation results in a normal endometrial function test (EFT) and good reproductive outcome in donor ovum recipients. Journal Of Assisted Reproduction And Genetics 2006, 23: 299-303. PMID: 16983518, DOI: 10.1007/s10815-006-9061-1.
- Catalanotti JS, Spandorfer SD, Barmat LI, Rosenwaks Z, McSweet JC, Kliman HJ. Mouse ascites Golgi mucin expression abnormalities in natural cycle endometrial biopsies predict subsequent in vitro fertilization-embryo transfer (IVF-ET) failure in patients with previous IVF-ET failures. Fertility And Sterility 2006, 85: 255-8. PMID: 16412771, DOI: 10.1016/j.fertnstert.2005.06.060.
- Kliman HJ, Segel L. The placenta may predict the baby. Journal Of Theoretical Biology 2003, 225: 143-5. PMID: 14559066, DOI: 10.1016/s0022-5193(03)00248-0.
- Dubowy RL, Feinberg RF, Keefe DL, Doncel GF, Williams SC, McSweet JC, Kliman HJ. Improved endometrial assessment using cyclin E and p27. Fertility And Sterility 2003, 80: 146-56. PMID: 12849817, DOI: 10.1016/s0015-0282(03)00573-9.
- Meaddough EL, Olive DL, Gallup P, Perlin M, Kliman HJ. Sexual activity, orgasm and tampon use are associated with a decreased risk for endometriosis. Gynecologic And Obstetric Investigation 2002, 53: 163-9. PMID: 12053101, DOI: 10.1159/000058368.
- Schwartz LB, Naftolin F, Lyttle CR, Penzias AS, Meaddough EL, Kliman HJ. Mouse ascites golgi (MAG) mucin expression and regulation by progesterone in the rat uterus. Journal Of The Society For Gynecologic Investigation 2001, 8: 216-23. PMID: 11525897, DOI: 10.1016/s1071-5576(01)00115-0.
- Kliman HJ. Uteroplacental blood flow. The story of decidualization, menstruation, and trophoblast invasion. The American Journal Of Pathology 2000, 157: 1759-68. PMID: 11106547, PMCID: PMC1885765, DOI: 10.1016/S0002-9440(10)64813-4.
- Acosta AA, Elberger L, Borghi M, Calamera JC, Chemes H, Doncel GF, Kliman H, Lema B, Lustig L, Papier S. Endometrial dating and determination of the window of implantation in healthy fertile women. Fertility And Sterility 2000, 73: 788-98. PMID: 10731542, DOI: 10.1016/s0015-0282(99)00605-6.
- Keltz MD, Attar E, Buradagunta S, Olive DL, Kliman HJ, Arici A. Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in the human fallopian tube. American Journal Of Obstetrics And Gynecology 1996, 175: 1611-9. PMID: 8987949, DOI: 10.1016/s0002-9378(96)70114-x.
- Nachtigall MJ, Kliman HJ, Feinberg RF, Olive DL, Engin O, Arici A. The effect of leukemia inhibitory factor (LIF) on trophoblast differentiation: a potential role in human implantation. The Journal Of Clinical Endocrinology And Metabolism 1996, 81: 801-6. PMID: 8636307, DOI: 10.1210/jcem.81.2.8636307.
- Arici A, Tazuke SI, Attar E, Kliman HJ, Olive DL. Interleukin-8 concentration in peritoneal fluid of patients with endometriosis and modulation of interleukin-8 expression in human mesothelial cells. Molecular Human Reproduction 1996, 2: 40-5. PMID: 9238656, DOI: 10.1093/molehr/2.1.40.
- Kliman HJ, Perrotta PL, Jones DC. The efficacy of the placental biopsy. American Journal Of Obstetrics And Gynecology 1995, 173: 1084-8. PMID: 7485298, DOI: 10.1016/0002-9378(95)91331-9.
- Keltz MD, Kliman HJ, Arici AM, Olive DL. Endosalpingiosis found at laparoscopy for chronic pelvic pain. Fertility And Sterility 1995, 64: 482-5. PMID: 7641898.
- Feinberg RF, Kliman HJ, Bedian V, Monzon-Bordonaba F, Menzin AW, Wang CL. Monoclonal antibody X18A4 identifies an oncofetal fibronectin epitope distinct from the FDC-6 binding site. American Journal Of Obstetrics And Gynecology 1995, 172: 1526-36. PMID: 7538728, DOI: 10.1016/0002-9378(95)90491-3.
- Bahado-Singh RO, Kliman H, Feng TY, Hobbins J, Copel JA, Mahoney MJ. First-trimester endocervical irrigation: feasibility of obtaining trophoblast cells for prenatal diagnosis. Obstetrics And Gynecology 1995, 85: 461-4. PMID: 7862393, DOI: 10.1016/0029-7844(94)00416-b.
- Kliman HJ, Feinberg RF, Schwartz LB, Feinman MA, Lavi E, Meaddough EL. A mucin-like glycoprotein identified by MAG (mouse ascites Golgi) antibodies. Menstrual cycle-dependent localization in human endometrium. The American Journal Of Pathology 1995, 146: 166-81. PMID: 7531946, PMCID: PMC1870765.
- Rotmensch S, Liberati M, Luo JS, Kliman HJ, Gollin Y, Bellati U, Hobbins JC, Copel JA. Color Doppler flow patterns and flow velocity waveforms of the intraplacental fetal circulation in growth-retarded fetuses. American Journal Of Obstetrics And Gynecology 1994, 171: 1257-64. PMID: 7977530, DOI: 10.1016/0002-9378(94)90143-0.
- Feinberg RF, Kliman HJ, Wang CL. Transforming growth factor-beta stimulates trophoblast oncofetal fibronectin synthesis in vitro: implications for trophoblast implantation in vivo. The Journal Of Clinical Endocrinology And Metabolism 1994, 78: 1241-8. PMID: 8175984, DOI: 10.1210/jcem.78.5.8175984.
- Kliman HJ. The placenta revealed. The American Journal Of Pathology 1993, 143: 332-6. PMID: 8342590, PMCID: PMC1887036.
- Feinberg RF, Kliman HJ. Fetal fibronectin and preterm labor. The New England Journal Of Medicine 1992, 326: 708; author reply 709. PMID: 1736115, DOI: 10.1056/NEJM199203053261013.
- Feinberg RF, Kliman HJ, Cohen AW. Preeclampsia, trisomy 13, and the placental bed. Obstetrics And Gynecology 1991, 78: 505-8. PMID: 1870809.
- Lavi E, Montone KT, Rorke LB, Kliman HJ. Fetal akinesia deformation sequence (Pena-Shokeir phenotype) associated with acquired intrauterine brain damage. Neurology 1991, 41: 1467-8. PMID: 1891100, DOI: 10.1212/wnl.41.9.1467.
- Feinberg RF, Kliman HJ, Lockwood CJ. Is oncofetal fibronectin a trophoblast glue for human implantation? The American Journal Of Pathology 1991, 138: 537-43. PMID: 2000933, PMCID: PMC1886265.
- Coutifaris C, Babalola GO, Abisogun AO, Kao LC, Chin U, Vadillo-Ortega F, Osheroff J, Kliman HJ, Strauss JF. In vitro systems for the study of human trophoblast implantation. Annals Of The New York Academy Of Sciences 1991, 622: 191-201. PMID: 2064180, DOI: 10.1111/j.1749-6632.1991.tb37862.x.
- Kliman HJ, Feinberg RF, Haimowitz JE. Human trophoblast-endometrial interactions in an in vitro suspension culture system. Placenta 1990, 11: 349-67. PMID: 2235916, DOI: 10.1016/s0143-4004(05)80226-7.
- Kliman HJ, Feinberg RF. Human trophoblast-extracellular matrix (ECM) interactions in vitro: ECM thickness modulates morphology and proteolytic activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1990, 87: 3057-61. PMID: 2326266, PMCID: PMC53833, DOI: 10.1073/pnas.87.8.3057.
- Babalola GO, Coutifaris C, Soto EA, Kliman HJ, Shuman H, Strauss JF. Aggregation of dispersed human cytotrophoblastic cells: lessons relevant to the morphogenesis of the placenta. Developmental Biology 1990, 137: 100-8. PMID: 2295358, DOI: 10.1016/0012-1606(90)90011-7.
- Feinberg RF, Kao LC, Haimowitz JE, Queenan JT, Wun TC, Strauss JF, Kliman HJ. Plasminogen activator inhibitor types 1 and 2 in human trophoblasts. PAI-1 is an immunocytochemical marker of invading trophoblasts. Laboratory Investigation; A Journal Of Technical Methods And Pathology 1989, 61: 20-6. PMID: 2473276.
- Nulsen JC, Silavin SL, Kao LC, Ringler GE, Kliman HJ, Strauss JF. Control of the steroidogenic machinery of the human trophoblast by cyclic AMP. Journal Of Reproduction And Fertility. Supplement 1989, 37: 147-53. PMID: 2553955.
- Kliman HJ, Coutifaris C, Babalola GO, Soto EA, Kao LC, Queenan JT, Feinberg RF, Strauss JF. The human trophoblast: homotypic and heterotypic cell-cell interactions. Progress In Clinical And Biological Research 1989, 294: 425-34. PMID: 2726976.
- Kao LC, Caltabiano S, Wu S, Strauss JF, Kliman HJ. The human villous cytotrophoblast: interactions with extracellular matrix proteins, endocrine function, and cytoplasmic differentiation in the absence of syncytium formation. Developmental Biology 1988, 130: 693-702. PMID: 2848742, DOI: 10.1016/0012-1606(88)90361-2.
- Roy-Choudhury S, Sen-Majumdar A, Murthy U, Mishra VS, Kliman HJ, Nestler JE, Strauss JF, Das M. Biosynthesis and turnover of a 34-kDa protein growth factor in human cytotrophoblasts. European Journal Of Biochemistry / FEBS 1988, 172: 777-83. PMID: 3350024, DOI: 10.1111/j.1432-1033.1988.tb13957.x.
- Feinman MA, Kliman HJ, Main EK. HLA antigen expression and induction by gamma-interferon in cultured human trophoblasts. American Journal Of Obstetrics And Gynecology 1987, 157: 1429-34. PMID: 3122576, DOI: 10.1016/s0002-9378(87)80238-7.
- Ulloa-Aguirre A, August AM, Golos TG, Kao LC, Sakuragi N, Kliman HJ, Strauss JF. 8-Bromo-adenosine 3',5'-monophosphate regulates expression of chorionic gonadotropin and fibronectin in human cytotrophoblasts. The Journal Of Clinical Endocrinology And Metabolism 1987, 64: 1002-9. PMID: 2435752, DOI: 10.1210/jcem-64-5-1002.
- Feinman MA, Kliman HJ, Caltabiano S, Strauss JF. 8-Bromo-3',5'-adenosine monophosphate stimulates the endocrine activity of human cytotrophoblasts in culture. The Journal Of Clinical Endocrinology And Metabolism 1986, 63: 1211-7. PMID: 3531221, DOI: 10.1210/jcem-63-5-1211.
- Kliman HJ, Nestler JE, Sermasi E, Sanger JM, Strauss JF. Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae. Endocrinology 1986, 118: 1567-82. PMID: 3512258, DOI: 10.1210/endo-118-4-1567.
- Soto EA, Kliman HJ, Strauss JF, Paavola LG. Gonadotropins and cyclic adenosine 3',5'-monophosphate (cAMP) alter the morphology of cultured human granulosa cells. Biology Of Reproduction 1986, 34: 559-69. PMID: 3008869, DOI: 10.1095/biolreprod34.3.559.
- Ballas SK, Kliman HJ, Smith ED. Glyceraldehyde-3-phosphate dehydrogenase of rat erythrocytes has no membrane component. Biochimica Et Biophysica Acta 1985, 831: 142-9. PMID: 4041465, DOI: 10.1016/0167-4838(85)90161-x.
- Kliman HJ, Steck TL. Association of glyceraldehyde-3-phosphate dehydrogenase with the human red cell membrane. A kinetic analysis. The Journal Of Biological Chemistry 1980, 255: 6314-21. PMID: 7391020.
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