Harlan Krumholz, MD, SM
Cardiovascular Medicine, Dermatology, Hand Surgery, Spine Surgery
Titles
- Harold H. Hines, Jr. Professor of Medicine (Cardiology) and Professor in the Institute for Social and Policy Studies, of Investigative Medicine and of Public Health (Health Policy)
- Director, Center for Outcomes Research and Evaluation (CORE)
- sdf, 2016 - 2017 Trainees and Junior Faculty
Education & Training
- ASsdfs (2023)
- FellowBeth Israel Hospital/Harvard Medical School (1992)
- SMHarvardsd, Health Policy and Management (SM) (1992)
- Chief ResidentMoffitt Hospital/University of California, San Francisco (1989)
- ResidentUniversity of California, San Francisco (1988)
- MDHarvard University (1985)
- BSYale College, Biology (1980)
Additional Information
Honors & Recognitions
- Clinical Research Prize: American Heart Association (2019)
- Top-10 Distinguished International Cardiologists (for contributions to the development of cardiovascular medicine in China): Chinese Society of Cardiology (2018)
- Advisory Committee to the Director: National Institutes of Health (2015)
- China Friendship Award: People's Republic of China (2014)
- Quality of Care and Outcomes Research Outstanding Achievement Award: American Heart Association (2013)
- Distinguished Achievement Award: American Heart Association (2011)
- Board of Trustees: American College of Cardiology Foundation (2010)
- Board of Directors: American Board of Internal Medicine (2010)
- Distinguished Scientist Award: American Heart Association (2010)
- Elected member: Connecticut Academy of Science and Engineering (2008)
Board Certifications
- AB of Internal Medicine, Internal Medicine (1989)
Professional Service
- American College of Cardiology (2009 - Present): Steering Committee of the Hospital to Home (H2H) Initiative
- Institute of Medicine (2008 - Present): Evidentiary Recommendations for Qualification of Surrogate Endpoints for Chronic Disease Risk Committee
- National Cardiovascular Data Registry (2008 - Present): International Strategy Work Group
- American College of Cardiology/American Heart Association (2008 - Present): Methodology for the Selection and Creation of Performance Measures for Quantifying the Quality of Cardiovascular Care Writing Committee
- National Heart, Lung, and Blood Institute (2008 - Present): Expert Panel on Integrated CVD Risk Reduction in Adults and the Guidelines Implementation Work Group
- National Academy of Sciences, National Academy of Engineering, Institute of Medicine (2008 - Present): Committee on Human Rights
- American Heart Association (2007 - 2009): Standards for Measures Used for Public Reporting of Efficiency and Value in Health Care Writing Group
- American College of Cardiology/American Heart Association (2007 - 2009): Writing Group to Update the 2004 Guidelines for the Management of Patients with ST-Elevation Myocardial Infarction, of the June 2007 Focused Update of the 2004 Guidelines for the Management of Patients with ST-Elevation Myocardial Infarction
- American Heart Association (2007 - 2008): Implementation and Integration of Pre-hospital Electrocardiogram Programs into Systems of Care for Acute Coronary Syndrome Writing Group
- Yale School of Medicine (2007 - Present): MD-MHS Advisory Committee
Publications
- Faust JS, Du C, Liang C, Mayes KD, Renton B, Panthagani K, Krumholz HM. Excess Mortality in Massachusetts During the Delta and Omicron Waves of COVID-19. JAMA 2022, 328: 74-76. PMID: 35594035, PMCID: PMC9257575, DOI: 10.1001/jama.2022.8045.
- Bikdeli B, Zahedi Tajrishi F, Sadeghipour P, Talasaz AH, Fanikos J, Lippi G, Siegal DM, Eikelboom JW, Monreal M, Jimenez D, Connors JM, Ageno W, Barnes GD, Piazza G, Angiolillo DJ, Parikh SA, Kirtane AJ, Lopes RD, Bhatt DL, Weitz JI, Mehran R, Krumholz HM, Goldhaber SZ, Lip GYH. Efficacy and Safety Considerations With Dose-Reduced Direct Oral Anticoagulants: A Review. JAMA Cardiology 2022, 7: 747-759. PMID: 35648414, DOI: 10.1001/jamacardio.2022.1292.
- Murugiah K, Chen L, Dreyer RP, Bouras G, Safdar B, Lu Y, Spatz ES, Gupta A, Khera R, Ng VG, Bueno H, Tweet MS, Spertus JA, Hayes SN, Lansky A, Krumholz HM. Depression and Perceived Stress After Spontaneous Coronary Artery Dissection and Comparison With Other Acute Myocardial Infarction (the VIRGO Experience). The American Journal Of Cardiology 2022, 173: 33-38. PMID: 35365290, PMCID: PMC9133198, DOI: 10.1016/j.amjcard.2022.03.005.
- Khera R, Schuemie MJ, Lu Y, Ostropolets A, Chen R, Hripcsak G, Ryan PB, Krumholz HM, Suchard MA. Large-scale evidence generation and evaluation across a network of databases for type 2 diabetes mellitus (LEGEND-T2DM): a protocol for a series of multinational, real-world comparative cardiovascular effectiveness and safety studies. BMJ Open 2022, 12: e057977. PMID: 35680274, PMCID: PMC9185490, DOI: 10.1136/bmjopen-2021-057977.
- Cohen AB, Stump L, Krumholz HM, Cartiera M, Jain S, Scott Sussman L, Hsiao A, Lindop W, Ying AK, Kaul RL, Balcezak TJ, Tereffe W, Comerford M, Jacoby D, Navai N. Aligning mission to digital health strategy in academic medical centers. NPJ Digital Medicine 2022, 5: 67. PMID: 35654885, PMCID: PMC9163186, DOI: 10.1038/s41746-022-00608-7.
- Reply to: "Comment on: Falls in older adults after hospitalization for acute myocardial infarction".Goldstein DW, Hajduk AM, Song X, Tsang S, Geda M, McClurken JB, Tinetti ME, Krumholz HM, Chaudhry SI. Reply to: "Comment on: Falls in older adults after hospitalization for acute myocardial infarction". Journal Of The American Geriatrics Society 2022, 70: 1880-1881. PMID: 35332528, PMCID: PMC9177624, DOI: 10.1111/jgs.17742.
- Trends in 10-Year Outcomes Among Medicare Beneficiaries Who Survived an Acute Myocardial Infarction.Wang Y, Leifheit EC, Krumholz HM. Trends in 10-Year Outcomes Among Medicare Beneficiaries Who Survived an Acute Myocardial Infarction. JAMA Cardiology 2022, 7: 613-622. PMID: 35507330, PMCID: PMC9069341, DOI: 10.1001/jamacardio.2022.0662.
- Bikdeli B, Piazza G, Jimenez D, Muriel A, Wang Y, Khairani CD, Rosovsky RP, Mehdipoor G, O'Donoghue ML, Spagnolo P, Dreyer RP, Bertoletti L, López-Jiménez L, Núñez MJ, Blanco-Molina Á, Bates SM, Gerhard-Herman M, Goldhaber SZ, Monreal M, Krumholz HM. Sex Differences in PrEsentation, Risk Factors, Drug and Interventional Therapies, and OUtcomes of Elderly PatientS with Pulmonary Embolism: Rationale and design of the SERIOUS-PE study. Thrombosis Research 2022, 214: 122-131. PMID: 35537232, DOI: 10.1016/j.thromres.2022.04.019.
- Guo W, Du X, Gao Y, Hu S, Lu Y, Dreyer RP, Li X, Spatz ES, Masoudi FA, Krumholz HM, Zheng X. Sex Differences in Characteristics, Treatments, and Outcomes Among Patients Hospitalized for Non-ST-Segment-Elevation Myocardial Infarction in China: 2006 to 2015. Circulation. Cardiovascular Quality And Outcomes 2022, 15: e008535. PMID: 35607994, PMCID: PMC9208815, DOI: 10.1161/CIRCOUTCOMES.121.008535.
- Lu Y, Melnick ER, Krumholz HM. Clinical decision support in cardiovascular medicine. BMJ (Clinical Research Ed.) 2022, 377: e059818. PMID: 35613721, DOI: 10.1136/bmj-2020-059818.
- Song J, Wang X, Wang B, Gao Y, Liu J, Zhang H, Li X, Li J, Wang JG, Cai J, Herrin J, Armitage J, Krumholz HM, Zheng X. Effectiveness of a clinical decision support system for hypertension management in primary care: study protocol for a pragmatic cluster-randomized controlled trial. Trials 2022, 23: 412. PMID: 35578345, PMCID: PMC9109449, DOI: 10.1186/s13063-022-06374-x.
- Kadakia KT, Krumholz HM. Designing Cures 2.0 - From Corridors to Cornerstones. The New England Journal Of Medicine 2022, 386: 1677-1679. PMID: 35485803, DOI: 10.1056/NEJMp2200203.
- Lu Y, Li SX, Liu Y, Rodriguez F, Watson KE, Dreyer RP, Khera R, Murugiah K, D'Onofrio G, Spatz ES, Nasir K, Masoudi FA, Krumholz HM. Sex-Specific Risk Factors Associated With First Acute Myocardial Infarction in Young Adults. JAMA Network Open 2022, 5: e229953. PMID: 35503221, PMCID: PMC9066284, DOI: 10.1001/jamanetworkopen.2022.9953.
- Khullar D, Casalino LP, Qian Y, Lu Y, Krumholz HM, Aneja S. Perspectives of Patients About Artificial Intelligence in Health Care. JAMA Network Open 2022, 5: e2210309. PMID: 35507346, PMCID: PMC9069257, DOI: 10.1001/jamanetworkopen.2022.10309.
- Wang Y, Eldridge N, Metersky ML, Rodrick D, Faniel C, Eckenrode S, Mathew J, Galusha DH, Tasimi A, Ho SY, Jaser L, Peterson A, Normand ST, Krumholz HM. Analysis of Hospital-Level Readmission Rates and Variation in Adverse Events Among Patients With Pneumonia in the United States. JAMA Network Open 2022, 5: e2214586. PMID: 35639379, PMCID: PMC9157270, DOI: 10.1001/jamanetworkopen.2022.14586.
- Kadakia KT, Ross JS, Krumholz HM. A Different Case of Penumbra-Reply: A Japanese Framework for Safe and Expedited Access to High-Risk Medical Devices. JAMA Internal Medicine 2022, 182: 570-571. PMID: 35285863, DOI: 10.1001/jamainternmed.2022.0105.
- Krumholz HM. 12th Korea Healthcare Congress 2021; 김치국부터 마시지 말라; The Time for Digital Health is Almost Here. Yonsei Medical Journal 2022, 63: 493-498. PMID: 35512753, PMCID: PMC9086693, DOI: 10.3349/ymj.2022.63.5.493.
- Bikdeli B, Khairani CD, Barns BM, Rosovsky RP, Jimenez D, Monreal M, Sylvester KW, Middeldorp S, Bates SM, Krumholz HM, Goldhaber SZ, Hunt BJ, Piazza G. Women's representation in venous thromboembolism randomized trials and registries: The illustrative example of direct oral anticoagulants for acute treatment. Contemporary Clinical Trials 2022, 115: 106714. PMID: 35202841, DOI: 10.1016/j.cct.2022.106714.
- Caraballo C, Mahajan S, Valero-Elizondo J, Massey D, Lu Y, Roy B, Riley C, Annapureddy AR, Murugiah K, Elumn J, Nasir K, Nunez-Smith M, Forman HP, Jackson CL, Herrin J, Krumholz HM. Evaluation of Temporal Trends in Racial and Ethnic Disparities in Sleep Duration Among US Adults, 2004-2018. JAMA Network Open 2022, 5: e226385. PMID: 35389500, PMCID: PMC8990329, DOI: 10.1001/jamanetworkopen.2022.6385.
- Sangha V, Mortazavi BJ, Haimovich AD, Ribeiro AH, Brandt CA, Jacoby DL, Schulz WL, Krumholz HM, Ribeiro ALP, Khera R. Automated multilabel diagnosis on electrocardiographic images and signals. Nature Communications 2022, 13: 1583. PMID: 35332137, PMCID: PMC8948243, DOI: 10.1038/s41467-022-29153-3.
- Commodore-Mensah Y, Loustalot F, Himmelfarb CD, Desvigne-Nickens P, Sachdev V, Bibbins-Domingo K, Clauser SB, Cohen DJ, Egan BM, Fendrick AM, Ferdinand KC, Goodman C, Graham GN, Jaffe MG, Krumholz HM, Levy PD, Mays GP, McNellis R, Muntner P, Ogedegbe G, Milani RV, Polgreen LA, Reisman L, Sanchez EJ, Sperling LS, Wall HK, Whitten L, Wright JT, Wright JS, Fine LJ. Proceedings From a National Heart, Lung, and Blood Institute and the Centers for Disease Control and Prevention Workshop to Control Hypertension. American Journal Of Hypertension 2022, 35: 232-243. PMID: 35259237, PMCID: PMC8903890, DOI: 10.1093/ajh/hpab182.
- Khera R, Mortazavi BJ, Sangha V, Warner F, Patrick Young H, Ross JS, Shah ND, Theel ES, Jenkinson WG, Knepper C, Wang K, Peaper D, Martinello RA, Brandt CA, Lin Z, Ko AI, Krumholz HM, Pollock BD, Schulz WL. A multicenter evaluation of computable phenotyping approaches for SARS-CoV-2 infection and COVID-19 hospitalizations. NPJ Digital Medicine 2022, 5: 27. PMID: 35260762, PMCID: PMC8904579, DOI: 10.1038/s41746-022-00570-4.
- Brush JE, Hajduk AM, Greene EJ, Dreyer RP, Krumholz HM, Chaudhry SI. Sex Differences in Symptom Phenotypes Among Older Patients with Acute Myocardial Infarction. The American Journal Of Medicine 2022, 135: 342-349. PMID: 34715061, PMCID: PMC8901454, DOI: 10.1016/j.amjmed.2021.09.022.
- Goldstein DW, Hajduk AM, Song X, Tsang S, Geda M, Dodson JA, Forman DE, Krumholz H, Chaudhry SI. Factors Associated With Cardiac Rehabilitation Participation in Older Adults After Myocardial Infarction: THE SILVER-AMI STUDY. Journal Of Cardiopulmonary Rehabilitation And Prevention 2022, 42: 109-114. PMID: 34799530, PMCID: PMC8881286, DOI: 10.1097/HCR.0000000000000627.
- Lu Y, Krumholz HM. Persistent Hypertension: A Broader Framework for Improving Blood Pressure Control. The American Journal Of Medicine 2022, 135: 273-275. PMID: 34656531, DOI: 10.1016/j.amjmed.2021.09.018.
- Riley C, Herrin J, Lam V, Parsons AA, Kaplan GA, Liu D, Witters D, Krumholz HM, Roy B. Trends and Variation in the Gap Between Current and Anticipated Life Satisfaction in the United States, 2008-2020. American Journal Of Public Health 2022, 112: 509-517. PMID: 35196041, PMCID: PMC8887183, DOI: 10.2105/AJPH.2021.306589.
- Lu Y, Van Zandt M, Liu Y, Li J, Wang X, Chen Y, Chen Z, Cho J, Dorajoo SR, Feng M, Hsu MH, Hsu JC, Iqbal U, Jonnagaddala J, Li YC, Liaw ST, Lim HS, Ngiam KY, Nguyen PA, Park RW, Pratt N, Reich C, Rhee SY, Sathappan SMK, Shin SJ, Tan HX, You SC, Zhang X, Krumholz HM, Suchard MA, Xu H. Analysis of Dual Combination Therapies Used in Treatment of Hypertension in a Multinational Cohort. JAMA Network Open 2022, 5: e223877. PMID: 35323951, PMCID: PMC8948532, DOI: 10.1001/jamanetworkopen.2022.3877.
- Mori M, Jarrin R, Lu Y, Kadakia K, Huang C, Ross JS, Krumholz HM. Sensible regulation and clinical implementation of clinical decision support software as a medical device. BMJ (Clinical Research Ed.) 2022, 376: o525. PMID: 35228206, DOI: 10.1136/bmj.o525.
- Howell BA, Puglisi LB, Aminawung J, Domingo KB, Elumn J, Gallagher C, Horton N, Kazi DS, Krumholz HM, Lin HJ, Roy B, Wang EA. A prospective cohort study examining exposure to incarceration and cardiovascular disease (Justice-Involved Individuals Cardiovascular Disease Epidemiology - JUSTICE study): a protocol paper. BMC Public Health 2022, 22: 331. PMID: 35172807, PMCID: PMC8848673, DOI: 10.1186/s12889-022-12688-x.
- Ngo L, Ali A, Ganesan A, Woodman R, Krumholz HM, Adams R, Ranasinghe I. Institutional Variation in 30-Day Complications Following Catheter Ablation of Atrial Fibrillation. Journal Of The American Heart Association 2022, 11: e022009. PMID: 35156395, PMCID: PMC9245833, DOI: 10.1161/JAHA.121.022009.
- Mori M, Spertus JA, Krumholz HM. Data-Driven Individualized Surgical Decision-making: Beyond "Better on Average" Clinical Trial Results. JAMA Surgery 2022, 157: 93-94. PMID: 34817547, DOI: 10.1001/jamasurg.2021.5614.
- Joel MZ, Umrao S, Chang E, Choi R, Yang DX, Duncan JS, Omuro A, Herbst R, Krumholz HM, Aneja S. Using Adversarial Images to Assess the Robustness of Deep Learning Models Trained on Diagnostic Images in Oncology. JCO Clinical Cancer Informatics 2022, 6: e2100170. PMID: 35271304, PMCID: PMC8932490, DOI: 10.1200/CCI.21.00170.
- Janke AT, Gettel CJ, Haimovich A, Kocher KE, Krumholz HM, Venkatesh AK. Changes in Emergency Department Arrival Times for Acute Myocardial Infarction During the COVID-19 Pandemic Suggest Delays in Care Seeking. Circulation. Cardiovascular Quality And Outcomes 2022, 15: e008402. PMID: 35105172, PMCID: PMC8833230, DOI: 10.1161/CIRCOUTCOMES.121.008402.
- Krumholz HM, Massey DS, Dorsey KB. Racism as a leading cause of death in the United States. BMJ (Clinical Research Ed.) 2022, 376: o213. PMID: 35078777, DOI: 10.1136/bmj.o213.
- Lu Y, Jones PW, Murugiah K, Caraballo C, Massey DS, Mahajan S, Ahmed R, Bader EM, Krumholz HM. Physical Activity Among Patients With Intracardiac Remote Monitoring Devices Before, During, and After COVID-19-Related Restrictions. Journal Of The American College Of Cardiology 2022, 79: 309-310. PMID: 35057917, PMCID: PMC8763290, DOI: 10.1016/j.jacc.2021.11.010.
- You SC, Krumholz HM. The Evolution of Evidence-Based Medicine: When the Magic of the Randomized Clinical Trial Meets Real-World Data. Circulation 2022, 145: 107-109. PMID: 35007161, DOI: 10.1161/CIRCULATIONAHA.121.057931.
- Bikdeli B, Talasaz AH, Rashidi F, Bakhshandeh H, Rafiee F, Rezaeifar P, Baghizadeh E, Matin S, Jamalkhani S, Tahamtan O, Sharif-Kashani B, Beigmohammadi MT, Farrokhpour M, Sezavar SH, Payandemehr P, Dabbagh A, Moghadam KG, Khalili H, Yadollahzadeh M, Riahi T, Abedini A, Lookzadeh S, Rahmani H, Zoghi E, Mohammadi K, Sadeghipour P, Abri H, Tabrizi S, Mousavian SM, Shahmirzaei S, Amin A, Mohebbi B, Parhizgar SE, Aliannejad R, Eslami V, Kashefizadeh A, Dobesh PP, Kakavand H, Hosseini SH, Shafaghi S, Ghazi SF, Najafi A, Jimenez D, Gupta A, Madhavan MV, Sethi SS, Parikh SA, Monreal M, Hadavand N, Hajighasemi A, Maleki M, Sadeghian S, Piazza G, Kirtane AJ, Van Tassell BW, Stone GW, Lip GYH, Krumholz H, Goldhaber SZ, Sadeghipour P. Intermediate-Dose versus Standard-Dose Prophylactic Anticoagulation in Patients with COVID-19 Admitted to the Intensive Care Unit: 90-Day Results from the INSPIRATION Randomized Trial. Thrombosis And Haemostasis 2022, 122: 131-141. PMID: 33865239, DOI: 10.1055/a-1485-2372.
- Jain S, Walkey AJ, Law AC, Ferrante LE, Lindenauer PK, Krumholz HM. Association between Residential Segregation and Long-Term Acute Care Hospital Performance on Improvement in Function among Ventilated Patients. Annals Of The American Thoracic Society 2022, 19: 147-150. PMID: 34644244, PMCID: PMC8787797, DOI: 10.1513/AnnalsATS.202107-796RL.
- Lu Y, Liu Y, Dhingra LS, Massey D, Caraballo C, Mahajan S, Spatz ES, Onuma O, Herrin J, Krumholz HM. National Trends in Racial and Ethnic Disparities in Antihypertensive Medication Use and Blood Pressure Control Among Adults With Hypertension, 2011-2018. Hypertension 2022, 79: 207-217. PMID: 34775785, DOI: 10.1161/HYPERTENSIONAHA.121.18381.
- Kadakia KT, Beckman AL, Ross JS, Krumholz HM. Renewing the Call for Reforms to Medical Device Safety-The Case of Penumbra. JAMA Internal Medicine 2022, 182: 59-65. PMID: 34842892, DOI: 10.1001/jamainternmed.2021.6626.
- Faust JS, Chen AJ, Nguemeni Tiako MJ, Du C, Li SX, Krumholz HM, Barnett ML. Leading Causes of Death Among Adults Aged 25 to 44 Years by Race and Ethnicity in Texas During the COVID-19 Pandemic, March to December 2020. JAMA Internal Medicine 2022, 182: 87-90. PMID: 34807250, PMCID: PMC8609460, DOI: 10.1001/jamainternmed.2021.6734.
- O'Laughlin KN, Thompson M, Hota B, Gottlieb M, Plumb ID, Chang AM, Wisk LE, Hall AJ, Wang RC, Spatz ES, Stephens KA, Huebinger RM, McDonald SA, Venkatesh A, Gentile N, Slovis BH, Hill M, Saydah S, Idris AH, Rodriguez R, Krumholz HM, Elmore JG, Weinstein RA, Nichol G. Study protocol for the Innovative Support for Patients with SARS-COV-2 Infections Registry (INSPIRE): A longitudinal study of the medium and long-term sequelae of SARS-CoV-2 infection. PloS One 2022, 17: e0264260. PMID: 35239680, PMCID: PMC8893622, DOI: 10.1371/journal.pone.0264260.
- Murugiah K, Chen L, Dreyer RP, Bouras G, Safdar B, Khera R, Lu Y, Spatz ES, Ng VG, Gupta A, Bueno H, Tweet MS, Spertus JA, Hayes SN, Lansky A, Krumholz HM. Health status outcomes after spontaneous coronary artery dissection and comparison with other acute myocardial infarction: The VIRGO experience. PloS One 2022, 17: e0265624. PMID: 35320296, PMCID: PMC8942215, DOI: 10.1371/journal.pone.0265624.
- Caraballo C, Mahajan S, Gu J, Lu Y, Spatz ES, Dreyer RP, Zhang M, Sun N, Ren Y, Zheng X, Zhao H, Lu H, Ma ZJ, Krumholz HM. Hemodynamic differences between women and men with elevated blood pressure in China: A non-invasive assessment of 45,082 adults using impedance cardiography. PloS One 2022, 17: e0269777. PMID: 35700163, PMCID: PMC9197037, DOI: 10.1371/journal.pone.0269777.
- Montoy JCC, Shen YC, Krumholz HM, Hsia RY. Association of STEMI regionalization of care with de facto NSTEMI regionalization. American Heart Journal 2021, 242: 1-5. PMID: 34274313, PMCID: PMC8568654, DOI: 10.1016/j.ahj.2021.07.002.
- Goldstein DW, Hajduk AM, Song X, Tsang S, Geda M, McClurken JB, Tinetti ME, Krumholz HM, Chaudhry SI. Falls in older adults after hospitalization for acute myocardial infarction. Journal Of The American Geriatrics Society 2021, 69: 3476-3485. PMID: 34383963, PMCID: PMC8882265, DOI: 10.1111/jgs.17398.
- Vazquez E, Gouraud H, Naudet F, Gross CP, Krumholz HM, Ross JS, Wallach JD. Characteristics of available studies and dissemination of research using major clinical data sharing platforms. Clinical Trials (London, England) 2021, 18: 657-666. PMID: 34407656, PMCID: PMC8595516, DOI: 10.1177/17407745211038524.
- Khera R, Mortazavi BJ, Krumholz HM. Assessing Performance of Machine Learning-Reply. JAMA Cardiology 2021, 6: 1466. PMID: 34586344, DOI: 10.1001/jamacardio.2021.3715.
- Murugiah K, Chen L, Castro-Dominguez Y, Khera R, Krumholz HM. Scope of Practice of US Interventional Cardiologists from an Analysis of Medicare Billing Data. The American Journal Of Cardiology 2021, 160: 40-45. PMID: 34610872, DOI: 10.1016/j.amjcard.2021.08.041.
- Sangha V, Lipska K, Lin Z, Inzucchi SE, McGuire DK, Krumholz HM, Khera R. Patterns of Prescribing Sodium-Glucose Cotransporter-2 Inhibitors for Medicare Beneficiaries in the United States. Circulation. Cardiovascular Quality And Outcomes 2021, 14: e008381. PMID: 34779654, PMCID: PMC9022137, DOI: 10.1161/CIRCOUTCOMES.121.008381.
- Wheelock KM, Ross JS, Murugiah K, Lin Z, Krumholz HM, Khera R. Clinician Trends in Prescribing Direct Oral Anticoagulants for US Medicare Beneficiaries. JAMA Network Open 2021, 4: e2137288. PMID: 34870678, PMCID: PMC8649845, DOI: 10.1001/jamanetworkopen.2021.37288.
- Mori M, Gupta A, Wang Y, Vahl T, Nazif T, Kirtane AJ, George I, Yong CM, Onuma O, Kodali S, Geirsson A, Leon MB, Krumholz HM. Trends in Transcatheter and Surgical Aortic Valve Replacement Among Older Adults in the United States. Journal Of The American College Of Cardiology 2021, 78: 2161-2172. PMID: 34823659, DOI: 10.1016/j.jacc.2021.09.855.
- Lu Y, Wang Y, Spatz ES, Onuma O, Nasir K, Rodriguez F, Watson KE, Krumholz HM. National Trends and Disparities in Hospitalization for Acute Hypertension Among Medicare Beneficiaries (1999-2019). Circulation 2021, 144: 1683-1693. PMID: 34743531, DOI: 10.1161/CIRCULATIONAHA.121.057056.
- Huang X, Dhruva SS, Yuan X, Bai X, Lu Y, Yan X, Liu J, Li W, Hu D, Ji R, Gao M, Miao F, Li J, Ge J, Krumholz HM, Li J. Characteristics, interventions and outcomes of patients with valvular heart disease hospitalised in China: a cross-sectional study. BMJ Open 2021, 11: e052946. PMID: 34732492, PMCID: PMC8572400, DOI: 10.1136/bmjopen-2021-052946.
- Khera R, Liu Y, de Lemos JA, Das SR, Pandey A, Omar W, Kumbhani DJ, Girotra S, Yeh RW, Rutan C, Walchok J, Lin Z, Bradley SM, Velazquez EJ, Churchwell KB, Nallamothu BK, Krumholz HM, Curtis JP. Association of COVID-19 Hospitalization Volume and Case Growth at US Hospitals with Patient Outcomes. The American Journal Of Medicine 2021, 134: 1380-1388.e3. PMID: 34343515, PMCID: PMC8325555, DOI: 10.1016/j.amjmed.2021.06.034.
- Talasaz AH, Sadeghipour P, Aghakouchakzadeh M, Dreyfus I, Kakavand H, Ariannejad H, Gupta A, Madhavan MV, Van Tassell BW, Jimenez D, Monreal M, Vaduganathan M, Fanikos J, Dixon DL, Piazza G, Parikh SA, Bhatt DL, Lip GYH, Stone GW, Krumholz HM, Libby P, Goldhaber SZ, Bikdeli B. Investigating Lipid-Modulating Agents for Prevention or Treatment of COVID-19: JACC State-of-the-Art Review. Journal Of The American College Of Cardiology 2021, 78: 1635-1654. PMID: 34649702, PMCID: PMC8504484, DOI: 10.1016/j.jacc.2021.08.021.
- Huang C, Li SX, Caraballo C, Masoudi FA, Rumsfeld JS, Spertus JA, Normand ST, Mortazavi BJ, Krumholz HM. Performance Metrics for the Comparative Analysis of Clinical Risk Prediction Models Employing Machine Learning. Circulation. Cardiovascular Quality And Outcomes 2021, 14: e007526. PMID: 34601947, DOI: 10.1161/CIRCOUTCOMES.120.007526.
- Raparelli V, Pilote L, Dang B, Behlouli H, Dziura JD, Bueno H, D'Onofrio G, Krumholz HM, Dreyer RP. Variations in Quality of Care by Sex and Social Determinants of Health Among Younger Adults With Acute Myocardial Infarction in the US and Canada. JAMA Network Open 2021, 4: e2128182. PMID: 34668947, PMCID: PMC8529414, DOI: 10.1001/jamanetworkopen.2021.28182.
- Ding Q, Massey D, Huang C, Grady CB, Lu Y, Cohen A, Matzner P, Mahajan S, Caraballo C, Kumar N, Xue Y, Dreyer R, Roy B, Krumholz HM. Tracking Self-reported Symptoms and Medical Conditions on Social Media During the COVID-19 Pandemic: Infodemiological Study. JMIR Public Health And Surveillance 2021, 7: e29413. PMID: 34517338, PMCID: PMC8480398, DOI: 10.2196/29413.
- Roy B, Hajduk AM, Tsang S, Geda M, Riley C, Krumholz HM, Chaudhry SI. The association of neighborhood walkability with health outcomes in older adults after acute myocardial infarction: The SILVER-AMI study. Preventive Medicine Reports 2021, 23: 101391. PMID: 34040930, PMCID: PMC8141908, DOI: 10.1016/j.pmedr.2021.101391.
- Chen R, Suchard MA, Krumholz HM, Schuemie MJ, Shea S, Duke J, Pratt N, Reich CG, Madigan D, You SC, Ryan PB, Hripcsak G. Comparative First-Line Effectiveness and Safety of ACE (Angiotensin-Converting Enzyme) Inhibitors and Angiotensin Receptor Blockers: A Multinational Cohort Study. Hypertension 2021, 78: 591-603. PMID: 34304580, PMCID: PMC8363588, DOI: 10.1161/HYPERTENSIONAHA.120.16667.
- Ozaki AF, Krumholz HM, Mody FV, Tran TT, Le QT, Yokota M, Jackevicius CA. Prior Authorization, Copayments, and Utilization of Sacubitril/Valsartan in Medicare and Commercial Plans in Patients With Heart Failure With Reduced Ejection Fraction. Circulation. Cardiovascular Quality And Outcomes 2021, 14: e007665. PMID: 34465124, DOI: 10.1161/CIRCOUTCOMES.120.007665.
- Zhou T, Li X, Lu Y, Murugiah K, Bai X, Hu S, Gao Y, Masoudi FA, Krumholz HM, Li J. Changes in ST segment elevation myocardial infarction hospitalisations in China from 2011 to 2015. Open Heart 2021, 8 PMID: 34599073, PMCID: PMC8488733, DOI: 10.1136/openhrt-2021-001666.
- Lu Y, Wang L, Wang H, Gu J, Ma ZJ, Lian Z, Zhang Z, Krumholz H, Sun N. Effectiveness of an impedance cardiography guided treatment strategy to improve blood pressure control in a real-world setting: results from a pragmatic clinical trial. Open Heart 2021, 8 PMID: 34580169, PMCID: PMC8477318, DOI: 10.1136/openhrt-2021-001719.
- Lu Y, Zhang H, Lu J, Ding Q, Li X, Wang X, Sun D, Tan L, Mu L, Liu J, Feng F, Yang H, Zhao H, Schulz WL, Krumholz HM, Pan X, Li J. Prevalence of Dyslipidemia and Availability of Lipid-Lowering Medications Among Primary Health Care Settings in China. JAMA Network Open 2021, 4: e2127573. PMID: 34586366, PMCID: PMC8482054, DOI: 10.1001/jamanetworkopen.2021.27573.
- Rossen LM, Ahmad FB, Anderson RN, Branum AM, Du C, Krumholz HM, Li SX, Lin Z, Marshall A, Sutton PD, Faust JS. Disparities in Excess Mortality Associated with COVID-19 - United States, 2020. MMWR. Morbidity And Mortality Weekly Report 2021, 70: 1114-1119. PMID: 34411075, PMCID: PMC8375709, DOI: 10.15585/mmwr.mm7033a2.
- Mahajan S, Caraballo C, Lu Y, Valero-Elizondo J, Massey D, Annapureddy AR, Roy B, Riley C, Murugiah K, Onuma O, Nunez-Smith M, Forman HP, Nasir K, Herrin J, Krumholz HM. Trends in Differences in Health Status and Health Care Access and Affordability by Race and Ethnicity in the United States, 1999-2018. JAMA 2021, 326: 637-648. PMID: 34402830, PMCID: PMC8371573, DOI: 10.1001/jama.2021.9907.
- Madhavan MV, Bikdeli B, Redfors B, Biondi-Zoccai G, Varunok NJ, Burton JR, Crowley A, Francese DP, Gupta A, Der Nigoghossian C, Chatterjee S, Palmerini T, Benedetto U, You SC, Ohman EM, Kastrati A, Steg PG, Gibson CM, Angiolillo DJ, Krumholz HM, Stone GW. Antiplatelet strategies in acute coronary syndromes: design and methodology of an international collaborative network meta-analysis of randomized controlled trials. Minerva Cardiology And Angiology 2021, 69: 398-407. PMID: 33258563, DOI: 10.23736/S2724-5683.20.05353-0.
- Mori M, Brooks C, Dhruva SS, Lu Y, Spatz ES, Dey P, Zhang Y, Chaudhry SI, Geirsson A, Allore HG, Krumholz HM. Trajectories of Pain After Cardiac Surgery: Implications for Measurement, Reporting, and Individualized Treatment. Circulation. Cardiovascular Quality And Outcomes 2021, 14: e007781. PMID: 34304586, PMCID: PMC8366534, DOI: 10.1161/CIRCOUTCOMES.120.007781.
- Ozaki AF, Krumholz HM, Mody FV, Jackevicius CA. National Trends in the Use of Sacubitril/Valsartan. Journal Of Cardiac Failure 2021, 27: 839-847. PMID: 34364661, DOI: 10.1016/j.cardfail.2021.05.015.
- Bikdeli B, Chatterjee S, Arora S, Monreal M, Jimenez D, Krumholz HM, Goldhaber SZ, Elkind MSV, Piazza G. Cerebral Venous Sinus Thrombosis in the U.S. Population, After Adenovirus-Based SARS-CoV-2 Vaccination, and After COVID-19. Journal Of The American College Of Cardiology 2021, 78: 408-411. PMID: 34116145, PMCID: PMC8186447, DOI: 10.1016/j.jacc.2021.06.001.
- Zinoviev R, Krumholz HM, Ciccarone R, Antle R, Forman HP. Multicentre methodological study to create a publicly available score of hospital financial standing in the USA. BMJ Open 2021, 11: e046500. PMID: 34301654, PMCID: PMC8311305, DOI: 10.1136/bmjopen-2020-046500.
- Wang SY, Valero-Elizondo J, Ali HJ, Pandey A, Cainzos-Achirica M, Krumholz HM, Nasir K, Khera R. Out-of-Pocket Annual Health Expenditures and Financial Toxicity From Healthcare Costs in Patients With Heart Failure in the United States. Journal Of The American Heart Association 2021, 10: e022164. PMID: 33998273, PMCID: PMC8483501, DOI: 10.1161/JAHA.121.022164.
- Riley C, Herrin J, Lam V, Hamar B, Witters D, Liu D, Krumholz HM, Roy B. Trends and geographical variation in population thriving, struggling and suffering across the USA, 2008-2017: a retrospective repeated cross-sectional study. BMJ Open 2021, 11: e043375. PMID: 34261676, PMCID: PMC8281074, DOI: 10.1136/bmjopen-2020-043375.
- Khera R, Clark C, Lu Y, Guo Y, Ren S, Truax B, Spatz ES, Murugiah K, Lin Z, Omer SB, Vojta D, Krumholz HM. Association of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers With the Risk of Hospitalization and Death in Hypertensive Patients With COVID-19. Journal Of The American Heart Association 2021, 10: e018086. PMID: 33624516, PMCID: PMC8403305, DOI: 10.1161/JAHA.120.018086.
- Nargesi AA, Jeyashanmugaraja GP, Desai N, Lipska K, Krumholz H, Khera R. Contemporary National Patterns of Eligibility and Use of Novel Cardioprotective Antihyperglycemic Agents in Type 2 Diabetes Mellitus. Journal Of The American Heart Association 2021, 10: e021084. PMID: 33998258, PMCID: PMC8403287, DOI: 10.1161/JAHA.121.021084.
- Faust JS, Du C, Mayes KD, Li SX, Lin Z, Barnett ML, Krumholz HM. Mortality From Drug Overdoses, Homicides, Unintentional Injuries, Motor Vehicle Crashes, and Suicides During the Pandemic, March-August 2020. JAMA 2021, 326: 84-86. PMID: 34019096, PMCID: PMC8140390, DOI: 10.1001/jama.2021.8012.
- Venkatesh AK, Greenwood-Ericksen MB, Mei H, Rothenberg C, Lin Z, Krumholz HM. Unscheduled Care Access in the United States-A Tale of Two Emergency Departments. The American Journal Of Emergency Medicine 2021, 45: 374-377. PMID: 33143957, PMCID: PMC8076339, DOI: 10.1016/j.ajem.2020.08.095.
- Massey D, Huang C, Lu Y, Cohen A, Oren Y, Moed T, Matzner P, Mahajan S, Caraballo C, Kumar N, Xue Y, Ding Q, Dreyer R, Roy B, Krumholz H. Engagement With COVID-19 Public Health Measures in the United States: A Cross-sectional Social Media Analysis from June to November 2020. Journal Of Medical Internet Research 2021, 23: e26655. PMID: 34086593, PMCID: PMC8218897, DOI: 10.2196/26655.
- Mahajan S, Caraballo C, Li SX, Dong Y, Chen L, Huston SK, Srinivasan R, Redlich CA, Ko AI, Faust JS, Forman HP, Krumholz HM. SARS-CoV-2 Infection Hospitalization Rate and Infection Fatality Rate Among the Non-Congregate Population in Connecticut. The American Journal Of Medicine 2021, 134: 812-816.e2. PMID: 33617808, PMCID: PMC7895685, DOI: 10.1016/j.amjmed.2021.01.020.
- Khera R, Haimovich J, Hurley NC, McNamara R, Spertus JA, Desai N, Rumsfeld JS, Masoudi FA, Huang C, Normand SL, Mortazavi BJ, Krumholz HM. Use of Machine Learning Models to Predict Death After Acute Myocardial Infarction. JAMA Cardiology 2021, 6: 633-641. PMID: 33688915, PMCID: PMC7948114, DOI: 10.1001/jamacardio.2021.0122.
- Melnick ER, Sinsky CA, Krumholz HM. Implementing Measurement Science for Electronic Health Record Use. JAMA 2021, 325: 2149-2150. PMID: 33818587, DOI: 10.1001/jama.2021.5487.
- Mori M, Durant TJS, Huang C, Mortazavi BJ, Coppi A, Jean RA, Geirsson A, Schulz WL, Krumholz HM. Toward Dynamic Risk Prediction of Outcomes After Coronary Artery Bypass Graft: Improving Risk Prediction With Intraoperative Events Using Gradient Boosting. Circulation. Cardiovascular Quality And Outcomes 2021, 14: e007363. PMID: 34078100, PMCID: PMC8635167, DOI: 10.1161/CIRCOUTCOMES.120.007363.
- Mu L, Liu J, Zhou G, Wu C, Chen B, Lu Y, Lu J, Yan X, Zhu Z, Nasir K, Spatz ES, Krumholz HM, Zheng X. Obesity Prevalence and Risks Among Chinese Adults: Findings From the China PEACE Million Persons Project, 2014-2018. Circulation. Cardiovascular Quality And Outcomes 2021, 14: e007292. PMID: 34107739, PMCID: PMC8204767, DOI: 10.1161/CIRCOUTCOMES.120.007292.
- Valero-Elizondo J, Chouairi F, Khera R, Grandhi GR, Saxena A, Warraich HJ, Virani SS, Desai NR, Sasangohar F, Krumholz HM, Esnaola NF, Nasir K. Atherosclerotic Cardiovascular Disease, Cancer, and Financial Toxicity Among Adults in the United States. JACC. CardioOncology 2021, 3: 236-246. PMID: 34396329, PMCID: PMC8352280, DOI: 10.1016/j.jaccao.2021.02.006.
- Chan You S, Krumholz HM, Suchard MA, Schuemie MJ, Hripcsak G, Chen R, Shea S, Duke J, Pratt N, Reich CG, Madigan D, Ryan PB, Woong Park R, Park S. Comprehensive Comparative Effectiveness and Safety of First-Line β-Blocker Monotherapy in Hypertensive Patients: A Large-Scale Multicenter Observational Study. Hypertension 2021, 77: 1528-1538. PMID: 33775125, PMCID: PMC8035236, DOI: 10.1161/HYPERTENSIONAHA.120.16402.
- Triche EW, Xin X, Stackland S, Purvis D, Harris A, Yu H, Grady JN, Li SX, Bernheim SM, Krumholz HM, Poyer J, Dorsey K. Incorporating Present-on-Admission Indicators in Medicare Claims to Inform Hospital Quality Measure Risk Adjustment Models. JAMA Network Open 2021, 4: e218512. PMID: 33978722, PMCID: PMC8116982, DOI: 10.1001/jamanetworkopen.2021.8512.
- Kadakia KT, Beckman AL, Ross JS, Krumholz HM. Leveraging Open Science to Accelerate Research. The New England Journal Of Medicine 2021, 384: e61. PMID: 33761227, DOI: 10.1056/NEJMp2034518.
- Sadeghipour P, Talasaz AH, Rashidi F, Sharif-Kashani B, Beigmohammadi MT, Farrokhpour M, Sezavar SH, Payandemehr P, Dabbagh A, Moghadam KG, Jamalkhani S, Khalili H, Yadollahzadeh M, Riahi T, Rezaeifar P, Tahamtan O, Matin S, Abedini A, Lookzadeh S, Rahmani H, Zoghi E, Mohammadi K, Sadeghipour P, Abri H, Tabrizi S, Mousavian SM, Shahmirzaei S, Bakhshandeh H, Amin A, Rafiee F, Baghizadeh E, Mohebbi B, Parhizgar SE, Aliannejad R, Eslami V, Kashefizadeh A, Kakavand H, Hosseini SH, Shafaghi S, Ghazi SF, Najafi A, Jimenez D, Gupta A, Madhavan MV, Sethi SS, Parikh SA, Monreal M, Hadavand N, Hajighasemi A, Maleki M, Sadeghian S, Piazza G, Kirtane AJ, Van Tassell BW, Dobesh PP, Stone GW, Lip GYH, Krumholz HM, Goldhaber SZ, Bikdeli B. Effect of Intermediate-Dose vs Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, Extracorporeal Membrane Oxygenation Treatment, or Mortality Among Patients With COVID-19 Admitted to the Intensive Care Unit: The INSPIRATION Randomized Clinical Trial. JAMA 2021, 325: 1620-1630. PMID: 33734299, PMCID: PMC7974835, DOI: 10.1001/jama.2021.4152.
- Talasaz AH, Sadeghipour P, Kakavand H, Aghakouchakzadeh M, Kordzadeh-Kermani E, Van Tassell BW, Gheymati A, Ariannejad H, Hosseini SH, Jamalkhani S, Sholzberg M, Monreal M, Jimenez D, Piazza G, Parikh SA, Kirtane AJ, Eikelboom JW, Connors JM, Hunt BJ, Konstantinides SV, Cushman M, Weitz JI, Stone GW, Krumholz HM, Lip GYH, Goldhaber SZ, Bikdeli B. Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19: JACC State-of-the-Art Review. Journal Of The American College Of Cardiology 2021, 77: 1903-1921. PMID: 33741176, PMCID: PMC7963001, DOI: 10.1016/j.jacc.2021.02.035.
- Ding Q, Spatz ES, Lipska KJ, Lin H, Spertus JA, Dreyer RP, Whittemore R, Funk M, Bueno H, Krumholz HM. Newly diagnosed diabetes and outcomes after acute myocardial infarction in young adults. Heart (British Cardiac Society) 2021, 107: 657-666. PMID: 33082173, PMCID: PMC8005796, DOI: 10.1136/heartjnl-2020-317101.
- Mahajan S, Srinivasan R, Redlich CA, Huston SK, Anastasio KM, Cashman L, Massey DS, Dugan A, Witters D, Marlar J, Li SX, Lin Z, Hodge D, Chattopadhyay M, Adams MD, Lee C, Rao LV, Stewart C, Kuppusamy K, Ko AI, Krumholz HM. Seroprevalence of SARS-CoV-2-Specific IgG Antibodies Among Adults Living in Connecticut: Post-Infection Prevalence (PIP) Study. The American Journal Of Medicine 2021, 134: 526-534.e11. PMID: 33130124, PMCID: PMC7598362, DOI: 10.1016/j.amjmed.2020.09.024.
- Dey P, Jarrin R, Mori M, Geirsson A, Krumholz HM. Leveraging Remote Physiologic Monitoring in the COVID-19 Pandemic to Improve Care After Cardiovascular Hospitalizations. Circulation. Cardiovascular Quality And Outcomes 2021, 14: e007618. PMID: 33820445, PMCID: PMC8059759, DOI: 10.1161/CIRCOUTCOMES.120.007618.
- Vogels CBF, Watkins AE, Harden CA, Brackney DE, Shafer J, Wang J, Caraballo C, Kalinich CC, Ott IM, Fauver JR, Kudo E, Lu P, Venkataraman A, Tokuyama M, Moore AJ, Muenker MC, Casanovas-Massana A, Fournier J, Bermejo S, Campbell M, Datta R, Nelson A, Dela Cruz CS, Ko AI, Iwasaki A, Krumholz HM, Matheus JD, Hui P, Liu C, Farhadian SF, Sikka R, Wyllie AL, Grubaugh ND. SalivaDirect: A simplified and flexible platform to enhance SARS-CoV-2 testing capacity. Med (New York, N.Y.) 2021, 2: 263-280.e6. PMID: 33521748, PMCID: PMC7836249, DOI: 10.1016/j.medj.2020.12.010.
- You SC, Gupta A, Krumholz HM. Ticagrelor vs Clopidogrel for Patients With Acute Coronary Syndrome Undergoing Percutaneous Intervention-Reply. JAMA 2021, 325: 890-891. PMID: 33651089, DOI: 10.1001/jama.2020.26023.
- Shen YC, Krumholz H, Hsia RY. Association of Cardiac Care Regionalization With Access, Treatment, and Mortality Among Patients With ST-Segment Elevation Myocardial Infarction. Circulation. Cardiovascular Quality And Outcomes 2021, 14: e007195. PMID: 33641339, PMCID: PMC7969448, DOI: 10.1161/CIRCOUTCOMES.120.007195.
- Shi X, Ross JS, Amancharla N, Niforatos JD, Krumholz HM, Wallach JD. Assessment of Concordance and Discordance Among Clinical Studies Posted as Preprints and Subsequently Published in High-Impact Journals. JAMA Network Open 2021, 4: e212110. PMID: 33734411, PMCID: PMC7974637, DOI: 10.1001/jamanetworkopen.2021.2110.
- Yang DX, Khera R, Miccio JA, Jairam V, Chang E, Yu JB, Park HS, Krumholz HM, Aneja S. Prevalence of Missing Data in the National Cancer Database and Association With Overall Survival. JAMA Network Open 2021, 4: e211793. PMID: 33755165, PMCID: PMC7988369, DOI: 10.1001/jamanetworkopen.2021.1793.
- Gupta A, Madhavan MV, Poterucha TJ, DeFilippis EM, Hennessey JA, Redfors B, Eckhardt C, Bikdeli B, Platt J, Nalbandian A, Elias P, Cummings MJ, Nouri SN, Lawlor M, Ranard LS, Li J, Boyle C, Givens R, Brodie D, Krumholz HM, Stone GW, Sethi SS, Burkhoff D, Uriel N, Schwartz A, Leon MB, Kirtane AJ, Wan EY, Parikh SA. Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19. Nature Communications 2021, 12: 1325. PMID: 33637713, PMCID: PMC7910606, DOI: 10.1038/s41467-021-21553-1.
- Faust JS, Krumholz HM, Du C, Mayes KD, Lin Z, Gilman C, Walensky RP. All-Cause Excess Mortality and COVID-19-Related Mortality Among US Adults Aged 25-44 Years, March-July 2020. JAMA 2021, 325: 785-787. PMID: 33325994, PMCID: PMC7745134, DOI: 10.1001/jama.2020.24243.
- Schulz WL, Young HP, Coppi A, Mortazavi BJ, Lin Z, Jean RA, Krumholz HM. Temporal relationship of computed and structured diagnoses in electronic health record data. BMC Medical Informatics And Decision Making 2021, 21: 61. PMID: 33596898, PMCID: PMC7890604, DOI: 10.1186/s12911-021-01416-x.
- Montoy JCC, Shen YC, Brindis RG, Krumholz HM, Hsia RY. Impact of ST-Segment-Elevation Myocardial Infarction Regionalization Programs on the Treatment and Outcomes of Patients Diagnosed With Non-ST-Segment-Elevation Myocardial Infarction. Journal Of The American Heart Association 2021, 10: e016932. PMID: 33470136, PMCID: PMC7955417, DOI: 10.1161/JAHA.120.016932.
- Fahed AC, Aragam KG, Hindy G, Chen YI, Chaudhary K, Dobbyn A, Krumholz HM, Sheu WHH, Rich SS, Rotter JI, Chowdhury R, Cho J, Do R, Ellinor PT, Kathiresan S, Khera AV. Transethnic Transferability of a Genome-Wide Polygenic Score for Coronary Artery Disease. Circulation. Genomic And Precision Medicine 2021, 14: e003092. PMID: 33284643, PMCID: PMC7887053, DOI: 10.1161/CIRCGEN.120.003092.
- Morales DR, Conover MM, You SC, Pratt N, Kostka K, Duarte-Salles T, Fernández-Bertolín S, Aragón M, DuVall SL, Lynch K, Falconer T, van Bochove K, Sung C, Matheny ME, Lambert CG, Nyberg F, Alshammari TM, Williams AE, Park RW, Weaver J, Sena AG, Schuemie MJ, Rijnbeek PR, Williams RD, Lane JCE, Prats-Uribe A, Zhang L, Areia C, Krumholz HM, Prieto-Alhambra D, Ryan PB, Hripcsak G, Suchard MA. Renin-angiotensin system blockers and susceptibility to COVID-19: an international, open science, cohort analysis. The Lancet. Digital Health 2021, 3: e98-e114. PMID: 33342753, PMCID: PMC7834915, DOI: 10.1016/S2589-7500(20)30289-2.
- Murugiah K, Gupta A, Krumholz HM. Time to Reperfusion in ST-Segment Elevation Acute Myocardial Infarction: When Does the Clock Start? Circulation. Cardiovascular Interventions 2021, 14: e010459. PMID: 33441005, DOI: 10.1161/CIRCINTERVENTIONS.121.010459.
- Mori M, Nasir K, Bao H, Jimenez A, Legore SS, Wang Y, Grady J, Lama SD, Brandi N, Lin Z, Kurlansky P, Geirsson A, Bernheim SM, Krumholz HM, Suter LG. Administrative Claims Measure for Profiling Hospital Performance Based on 90-Day All-Cause Mortality Following Coronary Artery Bypass Graft Surgery. Circulation. Cardiovascular Quality And Outcomes 2021, 14: e006644. PMID: 33535776, DOI: 10.1161/CIRCOUTCOMES.120.006644.
- Dhruva SS, Ross JS, Mortazavi BJ, Hurley NC, Krumholz HM, Curtis JP, Berkowitz AP, Masoudi FA, Messenger JC, Parzynski CS, Ngufor CG, Girotra S, Amin AP, Shah ND, Desai NR. Use of Mechanical Circulatory Support Devices Among Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock. JAMA Network Open 2021, 4: e2037748. PMID: 33616664, PMCID: PMC7900859, DOI: 10.1001/jamanetworkopen.2020.37748.
- Schuemie MJ, Ryan PB, Pratt N, Chen R, You SC, Krumholz HM, Madigan D, Hripcsak G, Suchard MA. Erratum to: Large-Scale Evidence Generation and Evaluation across a Network of Databases (LEGEND): Assessing Validity Using Hypertension as a Case Study. Journal Of The American Medical Informatics Association : JAMIA 2021, 28: 196. PMID: 33099616, PMCID: PMC7810446, DOI: 10.1093/jamia/ocaa256.
- Sikka R, Lincoln AE, Adamson BJS, Epstein JA, Krumholz HM. What's Important: Reopening Lessons from the Big Leagues' Experiences with COVID-19. The Journal Of Bone And Joint Surgery. American Volume 2021, 103: 1-3. PMID: 33196503, DOI: 10.2106/JBJS.20.01894.
- Angraal S, Zachariah AG, Raaisa R, Khera R, Rao P, Krumholz HM, Spertus JA. Evaluation of Internet-Based Crowdsourced Fundraising to Cover Health Care Costs in the United States. JAMA Network Open 2021, 4: e2033157. PMID: 33427882, PMCID: PMC7801937, DOI: 10.1001/jamanetworkopen.2020.33157.
- Faust JS, Shah SB, Du C, Li SX, Lin Z, Krumholz HM. Suicide Deaths During the COVID-19 Stay-at-Home Advisory in Massachusetts, March to May 2020. JAMA Network Open 2021, 4: e2034273. PMID: 33475750, PMCID: PMC7821026, DOI: 10.1001/jamanetworkopen.2020.34273.
- Zinoviev R, Krumholz HM, Pirruccio K, Forman H. Association of Graduate Medical Education With Hospital Performance and Patient Outcomes. JAMA Network Open 2021, 4: e2034196. PMID: 33507257, PMCID: PMC7844596, DOI: 10.1001/jamanetworkopen.2020.34196.
- Labrosciano C, Horton D, Air T, Tavella R, Beltrame JF, Zeitz CJ, Krumholz HM, Adams RJ, Scott IA, Gallagher M, Hossain S, Hariharaputhiran S, Ranasinghe I. Frequency, trends and institutional variation in 30-day all-cause mortality and unplanned readmissions following hospitalisation for heart failure in Australia and New Zealand. European Journal Of Heart Failure 2021, 23: 31-40. PMID: 33094886, DOI: 10.1002/ejhf.2030.
- Dodson JA, Hajduk AM, Murphy TE, Geda M, Krumholz HM, Tsang S, Nanna MG, Tinetti ME, Ouellet G, Sybrant D, Gill TM, Chaudhry SI. 180-day readmission risk model for older adults with acute myocardial infarction: the SILVER-AMI study. Open Heart 2021, 8 PMID: 33452007, PMCID: PMC7813425, DOI: 10.1136/openhrt-2020-001442.
- McPadden J, Warner F, Young HP, Hurley NC, Pulk RA, Singh A, Durant TJS, Gong G, Desai N, Haimovich A, Taylor RA, Gunel M, Dela Cruz CS, Farhadian SF, Siner J, Villanueva M, Churchwell K, Hsiao A, Torre CJ, Velazquez EJ, Herbst RS, Iwasaki A, Ko AI, Mortazavi BJ, Krumholz HM, Schulz WL. Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection. PloS One 2021, 16: e0243291. PMID: 33788846, PMCID: PMC8011821, DOI: 10.1371/journal.pone.0243291.
- Hurley NC, Spatz ES, Krumholz HM, Jafari R, Mortazavi BJ. A Survey of Challenges and Opportunities in Sensing and Analytics for Risk Factors of Cardiovascular Disorders. ACM Transactions On Computing For Healthcare 2021, 2 PMID: 34337602, PMCID: PMC8320445, DOI: 10.1145/3417958.
- Harshfield EL, Pennells L, Schwartz JE, Willeit P, Kaptoge S, Bell S, Shaffer JA, Bolton T, Spackman S, Wassertheil-Smoller S, Kee F, Amouyel P, Shea SJ, Kuller LH, Kauhanen J, van Zutphen EM, Blazer DG, Krumholz H, Nietert PJ, Kromhout D, Laughlin G, Berkman L, Wallace RB, Simons LA, Dennison EM, Barr ELM, Meyer HE, Wood AM, Danesh J, Di Angelantonio E, Davidson KW. Association Between Depressive Symptoms and Incident Cardiovascular Diseases. JAMA 2020, 324: 2396-2405. PMID: 33320224, PMCID: PMC7739139, DOI: 10.1001/jama.2020.23068.
- Mszar R, Mahajan S, Valero-Elizondo J, Yahya T, Sharma R, Grandhi GR, Khera R, Virani SS, Lichtman J, Khan SU, Cainzos-Achirica M, Vahidy FS, Krumholz HM, Nasir K. Association Between Sociodemographic Determinants and Disparities in Stroke Symptom Awareness Among US Young Adults. Stroke; A Journal Of Cerebral Circulation 2020, 51: 3552-3561. PMID: 33100188, DOI: 10.1161/STROKEAHA.120.031137.
- Desai NR, Krumholz HM. From Reactivity to Proactivity: On the Path to Pre-Empting Heart Failure Hospitalizations. JACC. Heart Failure 2020, 8: 1035-1037. PMID: 33189634, DOI: 10.1016/j.jchf.2020.09.007.
- Krumholz HM. Inflection Point: Ideas for Accelerating Breakthroughs and Improving Cardiovascular Health. Circulation. Cardiovascular Quality And Outcomes 2020, 13: e007615. PMID: 33200951, PMCID: PMC7742208, DOI: 10.1161/CIRCOUTCOMES.120.007615.
- Durant TJS, Jean RA, Huang C, Coppi A, Schulz WL, Geirsson A, Krumholz HM. Evaluation of a Risk Stratification Model Using Preoperative and Intraoperative Data for Major Morbidity or Mortality After Cardiac Surgical Treatment. JAMA Network Open 2020, 3: e2028361. PMID: 33284333, DOI: 10.1001/jamanetworkopen.2020.28361.
- Mahajan S, Feng F, Hu S, Lu Y, Gupta A, Murugiah K, Gao Y, Lu J, Liu J, Zheng X, Spatz ES, Zhang H, Krumholz HM, Li J. Assessment of Prevalence, Awareness, and Characteristics of Isolated Systolic Hypertension Among Younger and Middle-Aged Adults in China. JAMA Network Open 2020, 3: e209743. PMID: 33289843, PMCID: PMC7724558, DOI: 10.1001/jamanetworkopen.2020.9743.
- Mori M, Wang Y, Mahajan S, Geirsson A, Krumholz HM. Associations Between the Severity of Influenza Seasons and Mortality and Readmission Risks After Elective Surgical Aortic Valve Replacement and Coronary Artery Bypass Graft Surgery in Older Adults. JAMA Network Open 2020, 3: e2031078. PMID: 33355673, PMCID: PMC7758803, DOI: 10.1001/jamanetworkopen.2020.31078.
- Vaduganathan M, Butler J, Krumholz HM, Itchhaporia D, Stecker EC, Bhatt DL. Regulation of Cardiovascular Therapies During the COVID-19 Public Health Emergency. Journal Of The American College Of Cardiology 2020, 76: 2517-2521. PMID: 33213730, PMCID: PMC7669239, DOI: 10.1016/j.jacc.2020.09.594.
- Desai MM, Zogg CK, Ranasinghe I, Parzynski CS, Lin Z, Gorbaty M, Merrill A, Krumholz HM, Drye EE. Variation in Risk-standardized Rates and Causes of Unplanned Hospital Visits Within 7 Days of Hospital Outpatient Surgery. Annals Of Surgery 2020 PMID: 33214469, DOI: 10.1097/SLA.0000000000004627.
- Krumholz HM, Bloom T, Sever R, Rawlinson C, Inglis JR, Ross JS. Submissions and Downloads of Preprints in the First Year of medRxiv. JAMA 2020, 324: 1903-1905. PMID: 33170232, PMCID: PMC7656287, DOI: 10.1001/jama.2020.17529.
- Hsia RY, Krumholz H, Shen YC. Evaluation of STEMI Regionalization on Access, Treatment, and Outcomes Among Adults Living in Nonminority and Minority Communities. JAMA Network Open 2020, 3: e2025874. PMID: 33196809, PMCID: PMC7670311, DOI: 10.1001/jamanetworkopen.2020.25874.
- Bikdeli B, Chatterjee S, Kirtane AJ, Parikh SA, Andreozzi GM, Desai NR, Francese DP, Gibson CM, Piazza G, Goldhaber SZ, Eikelboom JW, Krumholz HM, Stone GW. Sulodexide versus Control and the Risk of Thrombotic and Hemorrhagic Events: Meta-Analysis of Randomized Trials. Seminars In Thrombosis And Hemostasis 2020, 46: 908-918. PMID: 33086402, DOI: 10.1055/s-0040-1716874.
- You SC, Rho Y, Bikdeli B, Kim J, Siapos A, Weaver J, Londhe A, Cho J, Park J, Schuemie M, Suchard MA, Madigan D, Hripcsak G, Gupta A, Reich CG, Ryan PB, Park RW, Krumholz HM. Association of Ticagrelor vs Clopidogrel With Net Adverse Clinical Events in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention. JAMA 2020, 324: 1640-1650. PMID: 33107944, PMCID: PMC7592033, DOI: 10.1001/jama.2020.16167.
- Pendyal A, Rothenberg C, Scofi JE, Krumholz HM, Safdar B, Dreyer RP, Venkatesh AK. National Trends in Emergency Department Care Processes for Acute Myocardial Infarction in the United States, 2005 to 2015. Journal Of The American Heart Association 2020, 9: e017208. PMID: 33047624, PMCID: PMC7763391, DOI: 10.1161/JAHA.120.017208.
- Mori M, Wang Y, Murugiah K, Khera R, Gupta A, Vallabhajosyula P, Masoudi FA, Geirsson A, Krumholz HM. Trends in Reoperative Coronary Artery Bypass Graft Surgery for Older Adults in the United States, 1998 to 2017. Journal Of The American Heart Association 2020, 9: e016980. PMID: 33045889, PMCID: PMC7763387, DOI: 10.1161/JAHA.120.016980.
- Zhong Q, Gao Y, Zheng X, Chen J, Masoudi FA, Lu Y, Feng Y, Hu S, Zhang Q, Huang C, Wang Y, Krumholz HM, Li X, Zhou Y. Geographic Variation in Process and Outcomes of Care for Patients With Acute Myocardial Infarction in China From 2001 to 2015. JAMA Network Open 2020, 3: e2021182. PMID: 33095248, PMCID: PMC7584924, DOI: 10.1001/jamanetworkopen.2020.21182.
- Schulz WL, Kvedar JC, Krumholz HM. Agile analytics to support rapid knowledge pipelines. NPJ Digital Medicine 2020, 3: 108. PMID: 33594176, DOI: 10.1038/s41746-020-00309-z.
- Zhang L, Hurley NC, Ibrahim B, Spatz E, Krumholz HM, Jafari R, Mortazavi BJ. Developing Personalized Models of Blood Pressure Estimation from Wearable Sensors Data Using Minimally-trained Domain Adversarial Neural Networks. Proceedings Of Machine Learning Research 2020, 126: 97-120. PMID: 33649743, PMCID: PMC7916101.
- Inan OT, Tenaerts P, Prindiville SA, Reynolds HR, Dizon DS, Cooper-Arnold K, Turakhia M, Pletcher MJ, Preston KL, Krumholz HM, Marlin BM, Mandl KD, Klasnja P, Spring B, Iturriaga E, Campo R, Desvigne-Nickens P, Rosenberg Y, Steinhubl SR, Califf RM. Digitizing clinical trials. NPJ Digital Medicine 2020, 3: 101. PMID: 33594216, DOI: 10.1038/s41746-020-0302-y.
- Sel K, Brown A, Jang H, Krumholz HM, Lu N, Jafari R. A Wrist-worn Respiration Monitoring Device using Bio-Impedance. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society. IEEE Engineering In Medicine And Biology Society. Annual International Conference 2020, 2020: 3989-3993. PMID: 33018874, DOI: 10.1109/EMBC44109.2020.9176367.
- Mori M, Khera R, Lin Z, Ross JS, Schulz W, Krumholz HM. The Promise of Big Data and Digital Solutions in Building a Cardiovascular Learning System: Opportunities and Barriers. Methodist DeBakey Cardiovascular Journal 2020, 16: 212-219. PMID: 33133357, PMCID: PMC7587314, DOI: 10.14797/mdcj-16-3-212.
- Annapureddy AR, Angraal S, Caraballo C, Grimshaw A, Huang C, Mortazavi BJ, Krumholz HM. The National Institutes of Health funding for clinical research applying machine learning techniques in 2017. NPJ Digital Medicine 2020, 3: 13. PMID: 33514844, DOI: 10.1038/s41746-020-0223-9.
- Kuntz RE, Antman EM, Califf RM, Ingelfinger JR, Krumholz HM, Ommaya A, Peterson ED, Ross JS, Waldstreicher J, Wang SV, Zarin DA, Whicher DM, Siddiqi SM, Lopez MH. Individual Patient-Level Data Sharing for Continuous Learning: A Strategy for Trial Data Sharing. NAM Perspectives 2019, 2019 PMID: 34532668, PMCID: PMC8406566, DOI: 10.31478/201906b.
- Krumholz HM, Wang K, Lin Z, Dharmarajan K, Horwitz LI, Ross JS, Drye EE, Bernheim SM, Normand ST. Hospital-Readmission Risk - Isolating Hospital Effects from Patient Effects. The New England Journal Of Medicine 2017, 377: 1055-1064. PMID: 28902587, PMCID: PMC5671772, DOI: 10.1056/NEJMsa1702321.
- Chaudhry SI, Mattera JA, Curtis JP, Spertus JA, Herrin J, Lin Z, Phillips CO, Hodshon BV, Cooper LS, Krumholz HM. Telemonitoring in patients with heart failure. The New England Journal Of Medicine 2010, 363: 2301-9. PMID: 21080835, PMCID: PMC3237394, DOI: 10.1056/NEJMoa1010029.
- Ross JS, Normand SL, Wang Y, Ko DT, Chen J, Drye EE, Keenan PS, Lichtman JH, Bueno H, Schreiner GC, Krumholz HM. Hospital volume and 30-day mortality for three common medical conditions. The New England Journal Of Medicine 2010, 362: 1110-8. PMID: 20335587, PMCID: PMC2880468, DOI: 10.1056/NEJMsa0907130.
- Krumholz HM, Lee TH. Redefining quality--implications of recent clinical trials. The New England Journal Of Medicine 2008, 358: 2537-9. PMID: 18539915, DOI: 10.1056/NEJMp0803740.
- Jackevicius CA, Tu JV, Ross JS, Ko DT, Krumholz HM. Use of ezetimibe in the United States and Canada. The New England Journal Of Medicine 2008, 358: 1819-28. PMID: 18375999, DOI: 10.1056/NEJMsa0801461.
- Nallamothu BK, Bradley EH, Krumholz HM. Time to treatment in primary percutaneous coronary intervention. The New England Journal Of Medicine 2007, 357: 1631-8. PMID: 17942875, DOI: 10.1056/NEJMra065985.
- Bradley EH, Herrin J, Wang Y, Barton BA, Webster TR, Mattera JA, Roumanis SA, Curtis JP, Nallamothu BK, Magid DJ, McNamara RL, Parkosewich J, Loeb JM, Krumholz HM. Strategies for reducing the door-to-balloon time in acute myocardial infarction. The New England Journal Of Medicine 2006, 355: 2308-20. PMID: 17101617, DOI: 10.1056/NEJMsa063117.
- Vaccarino V, Rathore SS, Wenger NK, Frederick PD, Abramson JL, Barron HV, Manhapra A, Mallik S, Krumholz HM. Sex and racial differences in the management of acute myocardial infarction, 1994 through 2002. The New England Journal Of Medicine 2005, 353: 671-82. PMID: 16107620, PMCID: PMC2805130, DOI: 10.1056/NEJMsa032214.
- Rathore SS, Wang Y, Krumholz HM. Sex-based differences in the effect of digoxin for the treatment of heart failure. The New England Journal Of Medicine 2002, 347: 1403-11. PMID: 12409542, DOI: 10.1056/NEJMoa021266.
- Wu WC, Rathore SS, Wang Y, Radford MJ, Krumholz HM. Blood transfusion in elderly patients with acute myocardial infarction. The New England Journal Of Medicine 2001, 345: 1230-6. PMID: 11680442, DOI: 10.1056/NEJMoa010615.
- Chen J, Rathore SS, Radford MJ, Wang Y, Krumholz HM. Racial differences in the use of cardiac catheterization after acute myocardial infarction. The New England Journal Of Medicine 2001, 344: 1443-9. PMID: 11346810, DOI: 10.1056/NEJM200105103441906.
- Vaccarino V, Parsons L, Every NR, Barron HV, Krumholz HM. Sex-based differences in early mortality after myocardial infarction. National Registry of Myocardial Infarction 2 Participants. The New England Journal Of Medicine 1999, 341: 217-25. PMID: 10413733, DOI: 10.1056/NEJM199907223410401.
- Chen J, Radford MJ, Wang Y, Marciniak TA, Krumholz HM. Do "America's Best Hospitals" perform better for acute myocardial infarction? The New England Journal Of Medicine 1999, 340: 286-92. PMID: 9920954, DOI: 10.1056/NEJM199901283400407.
- Radford MJ, Krumholz HM. Beta-blockers after myocardial infarction--for few patients, or many? The New England Journal Of Medicine 1998, 339: 551-3. PMID: 9709049, DOI: 10.1056/NEJM199808203390809.
- Krumholz HM. Cardiac procedures, outcomes, and accountability. The New England Journal Of Medicine 1997, 336: 1522-3. PMID: 9154775, DOI: 10.1056/NEJM199705223362111.
- Krumholz HM, Pasternak RC, Weinstein MC, Friesinger GC, Ridker PM, Tosteson AN, Goldman L. Cost effectiveness of thrombolytic therapy with streptokinase in elderly patients with suspected acute myocardial infarction. The New England Journal Of Medicine 1992, 327: 7-13. PMID: 1598117, DOI: 10.1056/NEJM199207023270102.
Departments and Programs
Titles
- Harold H. Hines, Jr. Professor of Medicine (Cardiology) and Professor in the Institute for Social and Policy Studies, of Investigative Medicine and of Public Health (Health Policy)
- Director, Center for Outcomes Research and Evaluation (CORE)
- sdf, 2016 - 2017 Trainees and Junior Faculty
Education & Training
- ASsdfs (2023)
- FellowBeth Israel Hospital/Harvard Medical School (1992)
- SMHarvardsd, Health Policy and Management (SM) (1992)
- Chief ResidentMoffitt Hospital/University of California, San Francisco (1989)
- ResidentUniversity of California, San Francisco (1988)
- MDHarvard University (1985)
- BSYale College, Biology (1980)
Additional Information
Honors & Recognitions
- Clinical Research Prize: American Heart Association (2019)
- Top-10 Distinguished International Cardiologists (for contributions to the development of cardiovascular medicine in China): Chinese Society of Cardiology (2018)
- Advisory Committee to the Director: National Institutes of Health (2015)
- China Friendship Award: People's Republic of China (2014)
- Quality of Care and Outcomes Research Outstanding Achievement Award: American Heart Association (2013)
- Distinguished Achievement Award: American Heart Association (2011)
- Board of Trustees: American College of Cardiology Foundation (2010)
- Board of Directors: American Board of Internal Medicine (2010)
- Distinguished Scientist Award: American Heart Association (2010)
- Elected member: Connecticut Academy of Science and Engineering (2008)
Board Certifications
- AB of Internal Medicine, Internal Medicine (1989)
Professional Service
- American College of Cardiology (2009 - Present): Steering Committee of the Hospital to Home (H2H) Initiative
- Institute of Medicine (2008 - Present): Evidentiary Recommendations for Qualification of Surrogate Endpoints for Chronic Disease Risk Committee
- National Cardiovascular Data Registry (2008 - Present): International Strategy Work Group
- American College of Cardiology/American Heart Association (2008 - Present): Methodology for the Selection and Creation of Performance Measures for Quantifying the Quality of Cardiovascular Care Writing Committee
- National Heart, Lung, and Blood Institute (2008 - Present): Expert Panel on Integrated CVD Risk Reduction in Adults and the Guidelines Implementation Work Group
- National Academy of Sciences, National Academy of Engineering, Institute of Medicine (2008 - Present): Committee on Human Rights
- American Heart Association (2007 - 2009): Standards for Measures Used for Public Reporting of Efficiency and Value in Health Care Writing Group
- American College of Cardiology/American Heart Association (2007 - 2009): Writing Group to Update the 2004 Guidelines for the Management of Patients with ST-Elevation Myocardial Infarction, of the June 2007 Focused Update of the 2004 Guidelines for the Management of Patients with ST-Elevation Myocardial Infarction
- American Heart Association (2007 - 2008): Implementation and Integration of Pre-hospital Electrocardiogram Programs into Systems of Care for Acute Coronary Syndrome Writing Group
- Yale School of Medicine (2007 - Present): MD-MHS Advisory Committee
Publications
- Faust JS, Du C, Liang C, Mayes KD, Renton B, Panthagani K, Krumholz HM. Excess Mortality in Massachusetts During the Delta and Omicron Waves of COVID-19. JAMA 2022, 328: 74-76. PMID: 35594035, PMCID: PMC9257575, DOI: 10.1001/jama.2022.8045.
- Bikdeli B, Zahedi Tajrishi F, Sadeghipour P, Talasaz AH, Fanikos J, Lippi G, Siegal DM, Eikelboom JW, Monreal M, Jimenez D, Connors JM, Ageno W, Barnes GD, Piazza G, Angiolillo DJ, Parikh SA, Kirtane AJ, Lopes RD, Bhatt DL, Weitz JI, Mehran R, Krumholz HM, Goldhaber SZ, Lip GYH. Efficacy and Safety Considerations With Dose-Reduced Direct Oral Anticoagulants: A Review. JAMA Cardiology 2022, 7: 747-759. PMID: 35648414, DOI: 10.1001/jamacardio.2022.1292.
- Murugiah K, Chen L, Dreyer RP, Bouras G, Safdar B, Lu Y, Spatz ES, Gupta A, Khera R, Ng VG, Bueno H, Tweet MS, Spertus JA, Hayes SN, Lansky A, Krumholz HM. Depression and Perceived Stress After Spontaneous Coronary Artery Dissection and Comparison With Other Acute Myocardial Infarction (the VIRGO Experience). The American Journal Of Cardiology 2022, 173: 33-38. PMID: 35365290, PMCID: PMC9133198, DOI: 10.1016/j.amjcard.2022.03.005.
- Khera R, Schuemie MJ, Lu Y, Ostropolets A, Chen R, Hripcsak G, Ryan PB, Krumholz HM, Suchard MA. Large-scale evidence generation and evaluation across a network of databases for type 2 diabetes mellitus (LEGEND-T2DM): a protocol for a series of multinational, real-world comparative cardiovascular effectiveness and safety studies. BMJ Open 2022, 12: e057977. PMID: 35680274, PMCID: PMC9185490, DOI: 10.1136/bmjopen-2021-057977.
- Cohen AB, Stump L, Krumholz HM, Cartiera M, Jain S, Scott Sussman L, Hsiao A, Lindop W, Ying AK, Kaul RL, Balcezak TJ, Tereffe W, Comerford M, Jacoby D, Navai N. Aligning mission to digital health strategy in academic medical centers. NPJ Digital Medicine 2022, 5: 67. PMID: 35654885, PMCID: PMC9163186, DOI: 10.1038/s41746-022-00608-7.
- Reply to: "Comment on: Falls in older adults after hospitalization for acute myocardial infarction".Goldstein DW, Hajduk AM, Song X, Tsang S, Geda M, McClurken JB, Tinetti ME, Krumholz HM, Chaudhry SI. Reply to: "Comment on: Falls in older adults after hospitalization for acute myocardial infarction". Journal Of The American Geriatrics Society 2022, 70: 1880-1881. PMID: 35332528, PMCID: PMC9177624, DOI: 10.1111/jgs.17742.
- Trends in 10-Year Outcomes Among Medicare Beneficiaries Who Survived an Acute Myocardial Infarction.Wang Y, Leifheit EC, Krumholz HM. Trends in 10-Year Outcomes Among Medicare Beneficiaries Who Survived an Acute Myocardial Infarction. JAMA Cardiology 2022, 7: 613-622. PMID: 35507330, PMCID: PMC9069341, DOI: 10.1001/jamacardio.2022.0662.
- Bikdeli B, Piazza G, Jimenez D, Muriel A, Wang Y, Khairani CD, Rosovsky RP, Mehdipoor G, O'Donoghue ML, Spagnolo P, Dreyer RP, Bertoletti L, López-Jiménez L, Núñez MJ, Blanco-Molina Á, Bates SM, Gerhard-Herman M, Goldhaber SZ, Monreal M, Krumholz HM. Sex Differences in PrEsentation, Risk Factors, Drug and Interventional Therapies, and OUtcomes of Elderly PatientS with Pulmonary Embolism: Rationale and design of the SERIOUS-PE study. Thrombosis Research 2022, 214: 122-131. PMID: 35537232, DOI: 10.1016/j.thromres.2022.04.019.
- Guo W, Du X, Gao Y, Hu S, Lu Y, Dreyer RP, Li X, Spatz ES, Masoudi FA, Krumholz HM, Zheng X. Sex Differences in Characteristics, Treatments, and Outcomes Among Patients Hospitalized for Non-ST-Segment-Elevation Myocardial Infarction in China: 2006 to 2015. Circulation. Cardiovascular Quality And Outcomes 2022, 15: e008535. PMID: 35607994, PMCID: PMC9208815, DOI: 10.1161/CIRCOUTCOMES.121.008535.
- Lu Y, Melnick ER, Krumholz HM. Clinical decision support in cardiovascular medicine. BMJ (Clinical Research Ed.) 2022, 377: e059818. PMID: 35613721, DOI: 10.1136/bmj-2020-059818.
- Song J, Wang X, Wang B, Gao Y, Liu J, Zhang H, Li X, Li J, Wang JG, Cai J, Herrin J, Armitage J, Krumholz HM, Zheng X. Effectiveness of a clinical decision support system for hypertension management in primary care: study protocol for a pragmatic cluster-randomized controlled trial. Trials 2022, 23: 412. PMID: 35578345, PMCID: PMC9109449, DOI: 10.1186/s13063-022-06374-x.
- Kadakia KT, Krumholz HM. Designing Cures 2.0 - From Corridors to Cornerstones. The New England Journal Of Medicine 2022, 386: 1677-1679. PMID: 35485803, DOI: 10.1056/NEJMp2200203.
- Lu Y, Li SX, Liu Y, Rodriguez F, Watson KE, Dreyer RP, Khera R, Murugiah K, D'Onofrio G, Spatz ES, Nasir K, Masoudi FA, Krumholz HM. Sex-Specific Risk Factors Associated With First Acute Myocardial Infarction in Young Adults. JAMA Network Open 2022, 5: e229953. PMID: 35503221, PMCID: PMC9066284, DOI: 10.1001/jamanetworkopen.2022.9953.
- Khullar D, Casalino LP, Qian Y, Lu Y, Krumholz HM, Aneja S. Perspectives of Patients About Artificial Intelligence in Health Care. JAMA Network Open 2022, 5: e2210309. PMID: 35507346, PMCID: PMC9069257, DOI: 10.1001/jamanetworkopen.2022.10309.
- Wang Y, Eldridge N, Metersky ML, Rodrick D, Faniel C, Eckenrode S, Mathew J, Galusha DH, Tasimi A, Ho SY, Jaser L, Peterson A, Normand ST, Krumholz HM. Analysis of Hospital-Level Readmission Rates and Variation in Adverse Events Among Patients With Pneumonia in the United States. JAMA Network Open 2022, 5: e2214586. PMID: 35639379, PMCID: PMC9157270, DOI: 10.1001/jamanetworkopen.2022.14586.
- Kadakia KT, Ross JS, Krumholz HM. A Different Case of Penumbra-Reply: A Japanese Framework for Safe and Expedited Access to High-Risk Medical Devices. JAMA Internal Medicine 2022, 182: 570-571. PMID: 35285863, DOI: 10.1001/jamainternmed.2022.0105.
- Krumholz HM. 12th Korea Healthcare Congress 2021; 김치국부터 마시지 말라; The Time for Digital Health is Almost Here. Yonsei Medical Journal 2022, 63: 493-498. PMID: 35512753, PMCID: PMC9086693, DOI: 10.3349/ymj.2022.63.5.493.
- Bikdeli B, Khairani CD, Barns BM, Rosovsky RP, Jimenez D, Monreal M, Sylvester KW, Middeldorp S, Bates SM, Krumholz HM, Goldhaber SZ, Hunt BJ, Piazza G. Women's representation in venous thromboembolism randomized trials and registries: The illustrative example of direct oral anticoagulants for acute treatment. Contemporary Clinical Trials 2022, 115: 106714. PMID: 35202841, DOI: 10.1016/j.cct.2022.106714.
- Caraballo C, Mahajan S, Valero-Elizondo J, Massey D, Lu Y, Roy B, Riley C, Annapureddy AR, Murugiah K, Elumn J, Nasir K, Nunez-Smith M, Forman HP, Jackson CL, Herrin J, Krumholz HM. Evaluation of Temporal Trends in Racial and Ethnic Disparities in Sleep Duration Among US Adults, 2004-2018. JAMA Network Open 2022, 5: e226385. PMID: 35389500, PMCID: PMC8990329, DOI: 10.1001/jamanetworkopen.2022.6385.
- Sangha V, Mortazavi BJ, Haimovich AD, Ribeiro AH, Brandt CA, Jacoby DL, Schulz WL, Krumholz HM, Ribeiro ALP, Khera R. Automated multilabel diagnosis on electrocardiographic images and signals. Nature Communications 2022, 13: 1583. PMID: 35332137, PMCID: PMC8948243, DOI: 10.1038/s41467-022-29153-3.
- Commodore-Mensah Y, Loustalot F, Himmelfarb CD, Desvigne-Nickens P, Sachdev V, Bibbins-Domingo K, Clauser SB, Cohen DJ, Egan BM, Fendrick AM, Ferdinand KC, Goodman C, Graham GN, Jaffe MG, Krumholz HM, Levy PD, Mays GP, McNellis R, Muntner P, Ogedegbe G, Milani RV, Polgreen LA, Reisman L, Sanchez EJ, Sperling LS, Wall HK, Whitten L, Wright JT, Wright JS, Fine LJ. Proceedings From a National Heart, Lung, and Blood Institute and the Centers for Disease Control and Prevention Workshop to Control Hypertension. American Journal Of Hypertension 2022, 35: 232-243. PMID: 35259237, PMCID: PMC8903890, DOI: 10.1093/ajh/hpab182.
- Khera R, Mortazavi BJ, Sangha V, Warner F, Patrick Young H, Ross JS, Shah ND, Theel ES, Jenkinson WG, Knepper C, Wang K, Peaper D, Martinello RA, Brandt CA, Lin Z, Ko AI, Krumholz HM, Pollock BD, Schulz WL. A multicenter evaluation of computable phenotyping approaches for SARS-CoV-2 infection and COVID-19 hospitalizations. NPJ Digital Medicine 2022, 5: 27. PMID: 35260762, PMCID: PMC8904579, DOI: 10.1038/s41746-022-00570-4.
- Brush JE, Hajduk AM, Greene EJ, Dreyer RP, Krumholz HM, Chaudhry SI. Sex Differences in Symptom Phenotypes Among Older Patients with Acute Myocardial Infarction. The American Journal Of Medicine 2022, 135: 342-349. PMID: 34715061, PMCID: PMC8901454, DOI: 10.1016/j.amjmed.2021.09.022.
- Goldstein DW, Hajduk AM, Song X, Tsang S, Geda M, Dodson JA, Forman DE, Krumholz H, Chaudhry SI. Factors Associated With Cardiac Rehabilitation Participation in Older Adults After Myocardial Infarction: THE SILVER-AMI STUDY. Journal Of Cardiopulmonary Rehabilitation And Prevention 2022, 42: 109-114. PMID: 34799530, PMCID: PMC8881286, DOI: 10.1097/HCR.0000000000000627.
- Lu Y, Krumholz HM. Persistent Hypertension: A Broader Framework for Improving Blood Pressure Control. The American Journal Of Medicine 2022, 135: 273-275. PMID: 34656531, DOI: 10.1016/j.amjmed.2021.09.018.
- Riley C, Herrin J, Lam V, Parsons AA, Kaplan GA, Liu D, Witters D, Krumholz HM, Roy B. Trends and Variation in the Gap Between Current and Anticipated Life Satisfaction in the United States, 2008-2020. American Journal Of Public Health 2022, 112: 509-517. PMID: 35196041, PMCID: PMC8887183, DOI: 10.2105/AJPH.2021.306589.
- Lu Y, Van Zandt M, Liu Y, Li J, Wang X, Chen Y, Chen Z, Cho J, Dorajoo SR, Feng M, Hsu MH, Hsu JC, Iqbal U, Jonnagaddala J, Li YC, Liaw ST, Lim HS, Ngiam KY, Nguyen PA, Park RW, Pratt N, Reich C, Rhee SY, Sathappan SMK, Shin SJ, Tan HX, You SC, Zhang X, Krumholz HM, Suchard MA, Xu H. Analysis of Dual Combination Therapies Used in Treatment of Hypertension in a Multinational Cohort. JAMA Network Open 2022, 5: e223877. PMID: 35323951, PMCID: PMC8948532, DOI: 10.1001/jamanetworkopen.2022.3877.
- Mori M, Jarrin R, Lu Y, Kadakia K, Huang C, Ross JS, Krumholz HM. Sensible regulation and clinical implementation of clinical decision support software as a medical device. BMJ (Clinical Research Ed.) 2022, 376: o525. PMID: 35228206, DOI: 10.1136/bmj.o525.
- Howell BA, Puglisi LB, Aminawung J, Domingo KB, Elumn J, Gallagher C, Horton N, Kazi DS, Krumholz HM, Lin HJ, Roy B, Wang EA. A prospective cohort study examining exposure to incarceration and cardiovascular disease (Justice-Involved Individuals Cardiovascular Disease Epidemiology - JUSTICE study): a protocol paper. BMC Public Health 2022, 22: 331. PMID: 35172807, PMCID: PMC8848673, DOI: 10.1186/s12889-022-12688-x.
- Ngo L, Ali A, Ganesan A, Woodman R, Krumholz HM, Adams R, Ranasinghe I. Institutional Variation in 30-Day Complications Following Catheter Ablation of Atrial Fibrillation. Journal Of The American Heart Association 2022, 11: e022009. PMID: 35156395, PMCID: PMC9245833, DOI: 10.1161/JAHA.121.022009.
- Mori M, Spertus JA, Krumholz HM. Data-Driven Individualized Surgical Decision-making: Beyond "Better on Average" Clinical Trial Results. JAMA Surgery 2022, 157: 93-94. PMID: 34817547, DOI: 10.1001/jamasurg.2021.5614.
- Joel MZ, Umrao S, Chang E, Choi R, Yang DX, Duncan JS, Omuro A, Herbst R, Krumholz HM, Aneja S. Using Adversarial Images to Assess the Robustness of Deep Learning Models Trained on Diagnostic Images in Oncology. JCO Clinical Cancer Informatics 2022, 6: e2100170. PMID: 35271304, PMCID: PMC8932490, DOI: 10.1200/CCI.21.00170.
- Janke AT, Gettel CJ, Haimovich A, Kocher KE, Krumholz HM, Venkatesh AK. Changes in Emergency Department Arrival Times for Acute Myocardial Infarction During the COVID-19 Pandemic Suggest Delays in Care Seeking. Circulation. Cardiovascular Quality And Outcomes 2022, 15: e008402. PMID: 35105172, PMCID: PMC8833230, DOI: 10.1161/CIRCOUTCOMES.121.008402.
- Krumholz HM, Massey DS, Dorsey KB. Racism as a leading cause of death in the United States. BMJ (Clinical Research Ed.) 2022, 376: o213. PMID: 35078777, DOI: 10.1136/bmj.o213.
- Lu Y, Jones PW, Murugiah K, Caraballo C, Massey DS, Mahajan S, Ahmed R, Bader EM, Krumholz HM. Physical Activity Among Patients With Intracardiac Remote Monitoring Devices Before, During, and After COVID-19-Related Restrictions. Journal Of The American College Of Cardiology 2022, 79: 309-310. PMID: 35057917, PMCID: PMC8763290, DOI: 10.1016/j.jacc.2021.11.010.
- You SC, Krumholz HM. The Evolution of Evidence-Based Medicine: When the Magic of the Randomized Clinical Trial Meets Real-World Data. Circulation 2022, 145: 107-109. PMID: 35007161, DOI: 10.1161/CIRCULATIONAHA.121.057931.
- Bikdeli B, Talasaz AH, Rashidi F, Bakhshandeh H, Rafiee F, Rezaeifar P, Baghizadeh E, Matin S, Jamalkhani S, Tahamtan O, Sharif-Kashani B, Beigmohammadi MT, Farrokhpour M, Sezavar SH, Payandemehr P, Dabbagh A, Moghadam KG, Khalili H, Yadollahzadeh M, Riahi T, Abedini A, Lookzadeh S, Rahmani H, Zoghi E, Mohammadi K, Sadeghipour P, Abri H, Tabrizi S, Mousavian SM, Shahmirzaei S, Amin A, Mohebbi B, Parhizgar SE, Aliannejad R, Eslami V, Kashefizadeh A, Dobesh PP, Kakavand H, Hosseini SH, Shafaghi S, Ghazi SF, Najafi A, Jimenez D, Gupta A, Madhavan MV, Sethi SS, Parikh SA, Monreal M, Hadavand N, Hajighasemi A, Maleki M, Sadeghian S, Piazza G, Kirtane AJ, Van Tassell BW, Stone GW, Lip GYH, Krumholz H, Goldhaber SZ, Sadeghipour P. Intermediate-Dose versus Standard-Dose Prophylactic Anticoagulation in Patients with COVID-19 Admitted to the Intensive Care Unit: 90-Day Results from the INSPIRATION Randomized Trial. Thrombosis And Haemostasis 2022, 122: 131-141. PMID: 33865239, DOI: 10.1055/a-1485-2372.
- Jain S, Walkey AJ, Law AC, Ferrante LE, Lindenauer PK, Krumholz HM. Association between Residential Segregation and Long-Term Acute Care Hospital Performance on Improvement in Function among Ventilated Patients. Annals Of The American Thoracic Society 2022, 19: 147-150. PMID: 34644244, PMCID: PMC8787797, DOI: 10.1513/AnnalsATS.202107-796RL.
- Lu Y, Liu Y, Dhingra LS, Massey D, Caraballo C, Mahajan S, Spatz ES, Onuma O, Herrin J, Krumholz HM. National Trends in Racial and Ethnic Disparities in Antihypertensive Medication Use and Blood Pressure Control Among Adults With Hypertension, 2011-2018. Hypertension 2022, 79: 207-217. PMID: 34775785, DOI: 10.1161/HYPERTENSIONAHA.121.18381.
- Kadakia KT, Beckman AL, Ross JS, Krumholz HM. Renewing the Call for Reforms to Medical Device Safety-The Case of Penumbra. JAMA Internal Medicine 2022, 182: 59-65. PMID: 34842892, DOI: 10.1001/jamainternmed.2021.6626.
- Faust JS, Chen AJ, Nguemeni Tiako MJ, Du C, Li SX, Krumholz HM, Barnett ML. Leading Causes of Death Among Adults Aged 25 to 44 Years by Race and Ethnicity in Texas During the COVID-19 Pandemic, March to December 2020. JAMA Internal Medicine 2022, 182: 87-90. PMID: 34807250, PMCID: PMC8609460, DOI: 10.1001/jamainternmed.2021.6734.
- O'Laughlin KN, Thompson M, Hota B, Gottlieb M, Plumb ID, Chang AM, Wisk LE, Hall AJ, Wang RC, Spatz ES, Stephens KA, Huebinger RM, McDonald SA, Venkatesh A, Gentile N, Slovis BH, Hill M, Saydah S, Idris AH, Rodriguez R, Krumholz HM, Elmore JG, Weinstein RA, Nichol G. Study protocol for the Innovative Support for Patients with SARS-COV-2 Infections Registry (INSPIRE): A longitudinal study of the medium and long-term sequelae of SARS-CoV-2 infection. PloS One 2022, 17: e0264260. PMID: 35239680, PMCID: PMC8893622, DOI: 10.1371/journal.pone.0264260.
- Murugiah K, Chen L, Dreyer RP, Bouras G, Safdar B, Khera R, Lu Y, Spatz ES, Ng VG, Gupta A, Bueno H, Tweet MS, Spertus JA, Hayes SN, Lansky A, Krumholz HM. Health status outcomes after spontaneous coronary artery dissection and comparison with other acute myocardial infarction: The VIRGO experience. PloS One 2022, 17: e0265624. PMID: 35320296, PMCID: PMC8942215, DOI: 10.1371/journal.pone.0265624.
- Caraballo C, Mahajan S, Gu J, Lu Y, Spatz ES, Dreyer RP, Zhang M, Sun N, Ren Y, Zheng X, Zhao H, Lu H, Ma ZJ, Krumholz HM. Hemodynamic differences between women and men with elevated blood pressure in China: A non-invasive assessment of 45,082 adults using impedance cardiography. PloS One 2022, 17: e0269777. PMID: 35700163, PMCID: PMC9197037, DOI: 10.1371/journal.pone.0269777.
- Montoy JCC, Shen YC, Krumholz HM, Hsia RY. Association of STEMI regionalization of care with de facto NSTEMI regionalization. American Heart Journal 2021, 242: 1-5. PMID: 34274313, PMCID: PMC8568654, DOI: 10.1016/j.ahj.2021.07.002.
- Goldstein DW, Hajduk AM, Song X, Tsang S, Geda M, McClurken JB, Tinetti ME, Krumholz HM, Chaudhry SI. Falls in older adults after hospitalization for acute myocardial infarction. Journal Of The American Geriatrics Society 2021, 69: 3476-3485. PMID: 34383963, PMCID: PMC8882265, DOI: 10.1111/jgs.17398.
- Vazquez E, Gouraud H, Naudet F, Gross CP, Krumholz HM, Ross JS, Wallach JD. Characteristics of available studies and dissemination of research using major clinical data sharing platforms. Clinical Trials (London, England) 2021, 18: 657-666. PMID: 34407656, PMCID: PMC8595516, DOI: 10.1177/17407745211038524.
- Khera R, Mortazavi BJ, Krumholz HM. Assessing Performance of Machine Learning-Reply. JAMA Cardiology 2021, 6: 1466. PMID: 34586344, DOI: 10.1001/jamacardio.2021.3715.
- Murugiah K, Chen L, Castro-Dominguez Y, Khera R, Krumholz HM. Scope of Practice of US Interventional Cardiologists from an Analysis of Medicare Billing Data. The American Journal Of Cardiology 2021, 160: 40-45. PMID: 34610872, DOI: 10.1016/j.amjcard.2021.08.041.
- Sangha V, Lipska K, Lin Z, Inzucchi SE, McGuire DK, Krumholz HM, Khera R. Patterns of Prescribing Sodium-Glucose Cotransporter-2 Inhibitors for Medicare Beneficiaries in the United States. Circulation. Cardiovascular Quality And Outcomes 2021, 14: e008381. PMID: 34779654, PMCID: PMC9022137, DOI: 10.1161/CIRCOUTCOMES.121.008381.
- Wheelock KM, Ross JS, Murugiah K, Lin Z, Krumholz HM, Khera R. Clinician Trends in Prescribing Direct Oral Anticoagulants for US Medicare Beneficiaries. JAMA Network Open 2021, 4: e2137288. PMID: 34870678, PMCID: PMC8649845, DOI: 10.1001/jamanetworkopen.2021.37288.
- Mori M, Gupta A, Wang Y, Vahl T, Nazif T, Kirtane AJ, George I, Yong CM, Onuma O, Kodali S, Geirsson A, Leon MB, Krumholz HM. Trends in Transcatheter and Surgical Aortic Valve Replacement Among Older Adults in the United States. Journal Of The American College Of Cardiology 2021, 78: 2161-2172. PMID: 34823659, DOI: 10.1016/j.jacc.2021.09.855.
- Lu Y, Wang Y, Spatz ES, Onuma O, Nasir K, Rodriguez F, Watson KE, Krumholz HM. National Trends and Disparities in Hospitalization for Acute Hypertension Among Medicare Beneficiaries (1999-2019). Circulation 2021, 144: 1683-1693. PMID: 34743531, DOI: 10.1161/CIRCULATIONAHA.121.057056.
- Huang X, Dhruva SS, Yuan X, Bai X, Lu Y, Yan X, Liu J, Li W, Hu D, Ji R, Gao M, Miao F, Li J, Ge J, Krumholz HM, Li J. Characteristics, interventions and outcomes of patients with valvular heart disease hospitalised in China: a cross-sectional study. BMJ Open 2021, 11: e052946. PMID: 34732492, PMCID: PMC8572400, DOI: 10.1136/bmjopen-2021-052946.
- Khera R, Liu Y, de Lemos JA, Das SR, Pandey A, Omar W, Kumbhani DJ, Girotra S, Yeh RW, Rutan C, Walchok J, Lin Z, Bradley SM, Velazquez EJ, Churchwell KB, Nallamothu BK, Krumholz HM, Curtis JP. Association of COVID-19 Hospitalization Volume and Case Growth at US Hospitals with Patient Outcomes. The American Journal Of Medicine 2021, 134: 1380-1388.e3. PMID: 34343515, PMCID: PMC8325555, DOI: 10.1016/j.amjmed.2021.06.034.
- Talasaz AH, Sadeghipour P, Aghakouchakzadeh M, Dreyfus I, Kakavand H, Ariannejad H, Gupta A, Madhavan MV, Van Tassell BW, Jimenez D, Monreal M, Vaduganathan M, Fanikos J, Dixon DL, Piazza G, Parikh SA, Bhatt DL, Lip GYH, Stone GW, Krumholz HM, Libby P, Goldhaber SZ, Bikdeli B. Investigating Lipid-Modulating Agents for Prevention or Treatment of COVID-19: JACC State-of-the-Art Review. Journal Of The American College Of Cardiology 2021, 78: 1635-1654. PMID: 34649702, PMCID: PMC8504484, DOI: 10.1016/j.jacc.2021.08.021.
- Huang C, Li SX, Caraballo C, Masoudi FA, Rumsfeld JS, Spertus JA, Normand ST, Mortazavi BJ, Krumholz HM. Performance Metrics for the Comparative Analysis of Clinical Risk Prediction Models Employing Machine Learning. Circulation. Cardiovascular Quality And Outcomes 2021, 14: e007526. PMID: 34601947, DOI: 10.1161/CIRCOUTCOMES.120.007526.
- Raparelli V, Pilote L, Dang B, Behlouli H, Dziura JD, Bueno H, D'Onofrio G, Krumholz HM, Dreyer RP. Variations in Quality of Care by Sex and Social Determinants of Health Among Younger Adults With Acute Myocardial Infarction in the US and Canada. JAMA Network Open 2021, 4: e2128182. PMID: 34668947, PMCID: PMC8529414, DOI: 10.1001/jamanetworkopen.2021.28182.
- Ding Q, Massey D, Huang C, Grady CB, Lu Y, Cohen A, Matzner P, Mahajan S, Caraballo C, Kumar N, Xue Y, Dreyer R, Roy B, Krumholz HM. Tracking Self-reported Symptoms and Medical Conditions on Social Media During the COVID-19 Pandemic: Infodemiological Study. JMIR Public Health And Surveillance 2021, 7: e29413. PMID: 34517338, PMCID: PMC8480398, DOI: 10.2196/29413.
- Roy B, Hajduk AM, Tsang S, Geda M, Riley C, Krumholz HM, Chaudhry SI. The association of neighborhood walkability with health outcomes in older adults after acute myocardial infarction: The SILVER-AMI study. Preventive Medicine Reports 2021, 23: 101391. PMID: 34040930, PMCID: PMC8141908, DOI: 10.1016/j.pmedr.2021.101391.
- Chen R, Suchard MA, Krumholz HM, Schuemie MJ, Shea S, Duke J, Pratt N, Reich CG, Madigan D, You SC, Ryan PB, Hripcsak G. Comparative First-Line Effectiveness and Safety of ACE (Angiotensin-Converting Enzyme) Inhibitors and Angiotensin Receptor Blockers: A Multinational Cohort Study. Hypertension 2021, 78: 591-603. PMID: 34304580, PMCID: PMC8363588, DOI: 10.1161/HYPERTENSIONAHA.120.16667.
- Ozaki AF, Krumholz HM, Mody FV, Tran TT, Le QT, Yokota M, Jackevicius CA. Prior Authorization, Copayments, and Utilization of Sacubitril/Valsartan in Medicare and Commercial Plans in Patients With Heart Failure With Reduced Ejection Fraction. Circulation. Cardiovascular Quality And Outcomes 2021, 14: e007665. PMID: 34465124, DOI: 10.1161/CIRCOUTCOMES.120.007665.
- Zhou T, Li X, Lu Y, Murugiah K, Bai X, Hu S, Gao Y, Masoudi FA, Krumholz HM, Li J. Changes in ST segment elevation myocardial infarction hospitalisations in China from 2011 to 2015. Open Heart 2021, 8 PMID: 34599073, PMCID: PMC8488733, DOI: 10.1136/openhrt-2021-001666.
- Lu Y, Wang L, Wang H, Gu J, Ma ZJ, Lian Z, Zhang Z, Krumholz H, Sun N. Effectiveness of an impedance cardiography guided treatment strategy to improve blood pressure control in a real-world setting: results from a pragmatic clinical trial. Open Heart 2021, 8 PMID: 34580169, PMCID: PMC8477318, DOI: 10.1136/openhrt-2021-001719.
- Lu Y, Zhang H, Lu J, Ding Q, Li X, Wang X, Sun D, Tan L, Mu L, Liu J, Feng F, Yang H, Zhao H, Schulz WL, Krumholz HM, Pan X, Li J. Prevalence of Dyslipidemia and Availability of Lipid-Lowering Medications Among Primary Health Care Settings in China. JAMA Network Open 2021, 4: e2127573. PMID: 34586366, PMCID: PMC8482054, DOI: 10.1001/jamanetworkopen.2021.27573.
- Rossen LM, Ahmad FB, Anderson RN, Branum AM, Du C, Krumholz HM, Li SX, Lin Z, Marshall A, Sutton PD, Faust JS. Disparities in Excess Mortality Associated with COVID-19 - United States, 2020. MMWR. Morbidity And Mortality Weekly Report 2021, 70: 1114-1119. PMID: 34411075, PMCID: PMC8375709, DOI: 10.15585/mmwr.mm7033a2.
- Mahajan S, Caraballo C, Lu Y, Valero-Elizondo J, Massey D, Annapureddy AR, Roy B, Riley C, Murugiah K, Onuma O, Nunez-Smith M, Forman HP, Nasir K, Herrin J, Krumholz HM. Trends in Differences in Health Status and Health Care Access and Affordability by Race and Ethnicity in the United States, 1999-2018. JAMA 2021, 326: 637-648. PMID: 34402830, PMCID: PMC8371573, DOI: 10.1001/jama.2021.9907.
- Madhavan MV, Bikdeli B, Redfors B, Biondi-Zoccai G, Varunok NJ, Burton JR, Crowley A, Francese DP, Gupta A, Der Nigoghossian C, Chatterjee S, Palmerini T, Benedetto U, You SC, Ohman EM, Kastrati A, Steg PG, Gibson CM, Angiolillo DJ, Krumholz HM, Stone GW. Antiplatelet strategies in acute coronary syndromes: design and methodology of an international collaborative network meta-analysis of randomized controlled trials. Minerva Cardiology And Angiology 2021, 69: 398-407. PMID: 33258563, DOI: 10.23736/S2724-5683.20.05353-0.
- Mori M, Brooks C, Dhruva SS, Lu Y, Spatz ES, Dey P, Zhang Y, Chaudhry SI, Geirsson A, Allore HG, Krumholz HM. Trajectories of Pain After Cardiac Surgery: Implications for Measurement, Reporting, and Individualized Treatment. Circulation. Cardiovascular Quality And Outcomes 2021, 14: e007781. PMID: 34304586, PMCID: PMC8366534, DOI: 10.1161/CIRCOUTCOMES.120.007781.
- Ozaki AF, Krumholz HM, Mody FV, Jackevicius CA. National Trends in the Use of Sacubitril/Valsartan. Journal Of Cardiac Failure 2021, 27: 839-847. PMID: 34364661, DOI: 10.1016/j.cardfail.2021.05.015.
- Bikdeli B, Chatterjee S, Arora S, Monreal M, Jimenez D, Krumholz HM, Goldhaber SZ, Elkind MSV, Piazza G. Cerebral Venous Sinus Thrombosis in the U.S. Population, After Adenovirus-Based SARS-CoV-2 Vaccination, and After COVID-19. Journal Of The American College Of Cardiology 2021, 78: 408-411. PMID: 34116145, PMCID: PMC8186447, DOI: 10.1016/j.jacc.2021.06.001.
- Zinoviev R, Krumholz HM, Ciccarone R, Antle R, Forman HP. Multicentre methodological study to create a publicly available score of hospital financial standing in the USA. BMJ Open 2021, 11: e046500. PMID: 34301654, PMCID: PMC8311305, DOI: 10.1136/bmjopen-2020-046500.
- Wang SY, Valero-Elizondo J, Ali HJ, Pandey A, Cainzos-Achirica M, Krumholz HM, Nasir K, Khera R. Out-of-Pocket Annual Health Expenditures and Financial Toxicity From Healthcare Costs in Patients With Heart Failure in the United States. Journal Of The American Heart Association 2021, 10: e022164. PMID: 33998273, PMCID: PMC8483501, DOI: 10.1161/JAHA.121.022164.
- Riley C, Herrin J, Lam V, Hamar B, Witters D, Liu D, Krumholz HM, Roy B. Trends and geographical variation in population thriving, struggling and suffering across the USA, 2008-2017: a retrospective repeated cross-sectional study. BMJ Open 2021, 11: e043375. PMID: 34261676, PMCID: PMC8281074, DOI: 10.1136/bmjopen-2020-043375.
- Khera R, Clark C, Lu Y, Guo Y, Ren S, Truax B, Spatz ES, Murugiah K, Lin Z, Omer SB, Vojta D, Krumholz HM. Association of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers With the Risk of Hospitalization and Death in Hypertensive Patients With COVID-19. Journal Of The American Heart Association 2021, 10: e018086. PMID: 33624516, PMCID: PMC8403305, DOI: 10.1161/JAHA.120.018086.
- Nargesi AA, Jeyashanmugaraja GP, Desai N, Lipska K, Krumholz H, Khera R. Contemporary National Patterns of Eligibility and Use of Novel Cardioprotective Antihyperglycemic Agents in Type 2 Diabetes Mellitus. Journal Of The American Heart Association 2021, 10: e021084. PMID: 33998258, PMCID: PMC8403287, DOI: 10.1161/JAHA.121.021084.
- Faust JS, Du C, Mayes KD, Li SX, Lin Z, Barnett ML, Krumholz HM. Mortality From Drug Overdoses, Homicides, Unintentional Injuries, Motor Vehicle Crashes, and Suicides During the Pandemic, March-August 2020. JAMA 2021, 326: 84-86. PMID: 34019096, PMCID: PMC8140390, DOI: 10.1001/jama.2021.8012.
- Venkatesh AK, Greenwood-Ericksen MB, Mei H, Rothenberg C, Lin Z, Krumholz HM. Unscheduled Care Access in the United States-A Tale of Two Emergency Departments. The American Journal Of Emergency Medicine 2021, 45: 374-377. PMID: 33143957, PMCID: PMC8076339, DOI: 10.1016/j.ajem.2020.08.095.
- Massey D, Huang C, Lu Y, Cohen A, Oren Y, Moed T, Matzner P, Mahajan S, Caraballo C, Kumar N, Xue Y, Ding Q, Dreyer R, Roy B, Krumholz H. Engagement With COVID-19 Public Health Measures in the United States: A Cross-sectional Social Media Analysis from June to November 2020. Journal Of Medical Internet Research 2021, 23: e26655. PMID: 34086593, PMCID: PMC8218897, DOI: 10.2196/26655.
- Mahajan S, Caraballo C, Li SX, Dong Y, Chen L, Huston SK, Srinivasan R, Redlich CA, Ko AI, Faust JS, Forman HP, Krumholz HM. SARS-CoV-2 Infection Hospitalization Rate and Infection Fatality Rate Among the Non-Congregate Population in Connecticut. The American Journal Of Medicine 2021, 134: 812-816.e2. PMID: 33617808, PMCID: PMC7895685, DOI: 10.1016/j.amjmed.2021.01.020.
- Khera R, Haimovich J, Hurley NC, McNamara R, Spertus JA, Desai N, Rumsfeld JS, Masoudi FA, Huang C, Normand SL, Mortazavi BJ, Krumholz HM. Use of Machine Learning Models to Predict Death After Acute Myocardial Infarction. JAMA Cardiology 2021, 6: 633-641. PMID: 33688915, PMCID: PMC7948114, DOI: 10.1001/jamacardio.2021.0122.
- Melnick ER, Sinsky CA, Krumholz HM. Implementing Measurement Science for Electronic Health Record Use. JAMA 2021, 325: 2149-2150. PMID: 33818587, DOI: 10.1001/jama.2021.5487.
- Mori M, Durant TJS, Huang C, Mortazavi BJ, Coppi A, Jean RA, Geirsson A, Schulz WL, Krumholz HM. Toward Dynamic Risk Prediction of Outcomes After Coronary Artery Bypass Graft: Improving Risk Prediction With Intraoperative Events Using Gradient Boosting. Circulation. Cardiovascular Quality And Outcomes 2021, 14: e007363. PMID: 34078100, PMCID: PMC8635167, DOI: 10.1161/CIRCOUTCOMES.120.007363.
- Mu L, Liu J, Zhou G, Wu C, Chen B, Lu Y, Lu J, Yan X, Zhu Z, Nasir K, Spatz ES, Krumholz HM, Zheng X. Obesity Prevalence and Risks Among Chinese Adults: Findings From the China PEACE Million Persons Project, 2014-2018. Circulation. Cardiovascular Quality And Outcomes 2021, 14: e007292. PMID: 34107739, PMCID: PMC8204767, DOI: 10.1161/CIRCOUTCOMES.120.007292.
- Valero-Elizondo J, Chouairi F, Khera R, Grandhi GR, Saxena A, Warraich HJ, Virani SS, Desai NR, Sasangohar F, Krumholz HM, Esnaola NF, Nasir K. Atherosclerotic Cardiovascular Disease, Cancer, and Financial Toxicity Among Adults in the United States. JACC. CardioOncology 2021, 3: 236-246. PMID: 34396329, PMCID: PMC8352280, DOI: 10.1016/j.jaccao.2021.02.006.
- Chan You S, Krumholz HM, Suchard MA, Schuemie MJ, Hripcsak G, Chen R, Shea S, Duke J, Pratt N, Reich CG, Madigan D, Ryan PB, Woong Park R, Park S. Comprehensive Comparative Effectiveness and Safety of First-Line β-Blocker Monotherapy in Hypertensive Patients: A Large-Scale Multicenter Observational Study. Hypertension 2021, 77: 1528-1538. PMID: 33775125, PMCID: PMC8035236, DOI: 10.1161/HYPERTENSIONAHA.120.16402.
- Triche EW, Xin X, Stackland S, Purvis D, Harris A, Yu H, Grady JN, Li SX, Bernheim SM, Krumholz HM, Poyer J, Dorsey K. Incorporating Present-on-Admission Indicators in Medicare Claims to Inform Hospital Quality Measure Risk Adjustment Models. JAMA Network Open 2021, 4: e218512. PMID: 33978722, PMCID: PMC8116982, DOI: 10.1001/jamanetworkopen.2021.8512.
- Kadakia KT, Beckman AL, Ross JS, Krumholz HM. Leveraging Open Science to Accelerate Research. The New England Journal Of Medicine 2021, 384: e61. PMID: 33761227, DOI: 10.1056/NEJMp2034518.
- Sadeghipour P, Talasaz AH, Rashidi F, Sharif-Kashani B, Beigmohammadi MT, Farrokhpour M, Sezavar SH, Payandemehr P, Dabbagh A, Moghadam KG, Jamalkhani S, Khalili H, Yadollahzadeh M, Riahi T, Rezaeifar P, Tahamtan O, Matin S, Abedini A, Lookzadeh S, Rahmani H, Zoghi E, Mohammadi K, Sadeghipour P, Abri H, Tabrizi S, Mousavian SM, Shahmirzaei S, Bakhshandeh H, Amin A, Rafiee F, Baghizadeh E, Mohebbi B, Parhizgar SE, Aliannejad R, Eslami V, Kashefizadeh A, Kakavand H, Hosseini SH, Shafaghi S, Ghazi SF, Najafi A, Jimenez D, Gupta A, Madhavan MV, Sethi SS, Parikh SA, Monreal M, Hadavand N, Hajighasemi A, Maleki M, Sadeghian S, Piazza G, Kirtane AJ, Van Tassell BW, Dobesh PP, Stone GW, Lip GYH, Krumholz HM, Goldhaber SZ, Bikdeli B. Effect of Intermediate-Dose vs Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, Extracorporeal Membrane Oxygenation Treatment, or Mortality Among Patients With COVID-19 Admitted to the Intensive Care Unit: The INSPIRATION Randomized Clinical Trial. JAMA 2021, 325: 1620-1630. PMID: 33734299, PMCID: PMC7974835, DOI: 10.1001/jama.2021.4152.
- Talasaz AH, Sadeghipour P, Kakavand H, Aghakouchakzadeh M, Kordzadeh-Kermani E, Van Tassell BW, Gheymati A, Ariannejad H, Hosseini SH, Jamalkhani S, Sholzberg M, Monreal M, Jimenez D, Piazza G, Parikh SA, Kirtane AJ, Eikelboom JW, Connors JM, Hunt BJ, Konstantinides SV, Cushman M, Weitz JI, Stone GW, Krumholz HM, Lip GYH, Goldhaber SZ, Bikdeli B. Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19: JACC State-of-the-Art Review. Journal Of The American College Of Cardiology 2021, 77: 1903-1921. PMID: 33741176, PMCID: PMC7963001, DOI: 10.1016/j.jacc.2021.02.035.
- Ding Q, Spatz ES, Lipska KJ, Lin H, Spertus JA, Dreyer RP, Whittemore R, Funk M, Bueno H, Krumholz HM. Newly diagnosed diabetes and outcomes after acute myocardial infarction in young adults. Heart (British Cardiac Society) 2021, 107: 657-666. PMID: 33082173, PMCID: PMC8005796, DOI: 10.1136/heartjnl-2020-317101.
- Mahajan S, Srinivasan R, Redlich CA, Huston SK, Anastasio KM, Cashman L, Massey DS, Dugan A, Witters D, Marlar J, Li SX, Lin Z, Hodge D, Chattopadhyay M, Adams MD, Lee C, Rao LV, Stewart C, Kuppusamy K, Ko AI, Krumholz HM. Seroprevalence of SARS-CoV-2-Specific IgG Antibodies Among Adults Living in Connecticut: Post-Infection Prevalence (PIP) Study. The American Journal Of Medicine 2021, 134: 526-534.e11. PMID: 33130124, PMCID: PMC7598362, DOI: 10.1016/j.amjmed.2020.09.024.
- Dey P, Jarrin R, Mori M, Geirsson A, Krumholz HM. Leveraging Remote Physiologic Monitoring in the COVID-19 Pandemic to Improve Care After Cardiovascular Hospitalizations. Circulation. Cardiovascular Quality And Outcomes 2021, 14: e007618. PMID: 33820445, PMCID: PMC8059759, DOI: 10.1161/CIRCOUTCOMES.120.007618.
- Vogels CBF, Watkins AE, Harden CA, Brackney DE, Shafer J, Wang J, Caraballo C, Kalinich CC, Ott IM, Fauver JR, Kudo E, Lu P, Venkataraman A, Tokuyama M, Moore AJ, Muenker MC, Casanovas-Massana A, Fournier J, Bermejo S, Campbell M, Datta R, Nelson A, Dela Cruz CS, Ko AI, Iwasaki A, Krumholz HM, Matheus JD, Hui P, Liu C, Farhadian SF, Sikka R, Wyllie AL, Grubaugh ND. SalivaDirect: A simplified and flexible platform to enhance SARS-CoV-2 testing capacity. Med (New York, N.Y.) 2021, 2: 263-280.e6. PMID: 33521748, PMCID: PMC7836249, DOI: 10.1016/j.medj.2020.12.010.
- You SC, Gupta A, Krumholz HM. Ticagrelor vs Clopidogrel for Patients With Acute Coronary Syndrome Undergoing Percutaneous Intervention-Reply. JAMA 2021, 325: 890-891. PMID: 33651089, DOI: 10.1001/jama.2020.26023.
- Shen YC, Krumholz H, Hsia RY. Association of Cardiac Care Regionalization With Access, Treatment, and Mortality Among Patients With ST-Segment Elevation Myocardial Infarction. Circulation. Cardiovascular Quality And Outcomes 2021, 14: e007195. PMID: 33641339, PMCID: PMC7969448, DOI: 10.1161/CIRCOUTCOMES.120.007195.
- Shi X, Ross JS, Amancharla N, Niforatos JD, Krumholz HM, Wallach JD. Assessment of Concordance and Discordance Among Clinical Studies Posted as Preprints and Subsequently Published in High-Impact Journals. JAMA Network Open 2021, 4: e212110. PMID: 33734411, PMCID: PMC7974637, DOI: 10.1001/jamanetworkopen.2021.2110.
- Yang DX, Khera R, Miccio JA, Jairam V, Chang E, Yu JB, Park HS, Krumholz HM, Aneja S. Prevalence of Missing Data in the National Cancer Database and Association With Overall Survival. JAMA Network Open 2021, 4: e211793. PMID: 33755165, PMCID: PMC7988369, DOI: 10.1001/jamanetworkopen.2021.1793.
- Gupta A, Madhavan MV, Poterucha TJ, DeFilippis EM, Hennessey JA, Redfors B, Eckhardt C, Bikdeli B, Platt J, Nalbandian A, Elias P, Cummings MJ, Nouri SN, Lawlor M, Ranard LS, Li J, Boyle C, Givens R, Brodie D, Krumholz HM, Stone GW, Sethi SS, Burkhoff D, Uriel N, Schwartz A, Leon MB, Kirtane AJ, Wan EY, Parikh SA. Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19. Nature Communications 2021, 12: 1325. PMID: 33637713, PMCID: PMC7910606, DOI: 10.1038/s41467-021-21553-1.
- Faust JS, Krumholz HM, Du C, Mayes KD, Lin Z, Gilman C, Walensky RP. All-Cause Excess Mortality and COVID-19-Related Mortality Among US Adults Aged 25-44 Years, March-July 2020. JAMA 2021, 325: 785-787. PMID: 33325994, PMCID: PMC7745134, DOI: 10.1001/jama.2020.24243.
- Schulz WL, Young HP, Coppi A, Mortazavi BJ, Lin Z, Jean RA, Krumholz HM. Temporal relationship of computed and structured diagnoses in electronic health record data. BMC Medical Informatics And Decision Making 2021, 21: 61. PMID: 33596898, PMCID: PMC7890604, DOI: 10.1186/s12911-021-01416-x.
- Montoy JCC, Shen YC, Brindis RG, Krumholz HM, Hsia RY. Impact of ST-Segment-Elevation Myocardial Infarction Regionalization Programs on the Treatment and Outcomes of Patients Diagnosed With Non-ST-Segment-Elevation Myocardial Infarction. Journal Of The American Heart Association 2021, 10: e016932. PMID: 33470136, PMCID: PMC7955417, DOI: 10.1161/JAHA.120.016932.
- Fahed AC, Aragam KG, Hindy G, Chen YI, Chaudhary K, Dobbyn A, Krumholz HM, Sheu WHH, Rich SS, Rotter JI, Chowdhury R, Cho J, Do R, Ellinor PT, Kathiresan S, Khera AV. Transethnic Transferability of a Genome-Wide Polygenic Score for Coronary Artery Disease. Circulation. Genomic And Precision Medicine 2021, 14: e003092. PMID: 33284643, PMCID: PMC7887053, DOI: 10.1161/CIRCGEN.120.003092.
- Morales DR, Conover MM, You SC, Pratt N, Kostka K, Duarte-Salles T, Fernández-Bertolín S, Aragón M, DuVall SL, Lynch K, Falconer T, van Bochove K, Sung C, Matheny ME, Lambert CG, Nyberg F, Alshammari TM, Williams AE, Park RW, Weaver J, Sena AG, Schuemie MJ, Rijnbeek PR, Williams RD, Lane JCE, Prats-Uribe A, Zhang L, Areia C, Krumholz HM, Prieto-Alhambra D, Ryan PB, Hripcsak G, Suchard MA. Renin-angiotensin system blockers and susceptibility to COVID-19: an international, open science, cohort analysis. The Lancet. Digital Health 2021, 3: e98-e114. PMID: 33342753, PMCID: PMC7834915, DOI: 10.1016/S2589-7500(20)30289-2.
- Murugiah K, Gupta A, Krumholz HM. Time to Reperfusion in ST-Segment Elevation Acute Myocardial Infarction: When Does the Clock Start? Circulation. Cardiovascular Interventions 2021, 14: e010459. PMID: 33441005, DOI: 10.1161/CIRCINTERVENTIONS.121.010459.
- Mori M, Nasir K, Bao H, Jimenez A, Legore SS, Wang Y, Grady J, Lama SD, Brandi N, Lin Z, Kurlansky P, Geirsson A, Bernheim SM, Krumholz HM, Suter LG. Administrative Claims Measure for Profiling Hospital Performance Based on 90-Day All-Cause Mortality Following Coronary Artery Bypass Graft Surgery. Circulation. Cardiovascular Quality And Outcomes 2021, 14: e006644. PMID: 33535776, DOI: 10.1161/CIRCOUTCOMES.120.006644.
- Dhruva SS, Ross JS, Mortazavi BJ, Hurley NC, Krumholz HM, Curtis JP, Berkowitz AP, Masoudi FA, Messenger JC, Parzynski CS, Ngufor CG, Girotra S, Amin AP, Shah ND, Desai NR. Use of Mechanical Circulatory Support Devices Among Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock. JAMA Network Open 2021, 4: e2037748. PMID: 33616664, PMCID: PMC7900859, DOI: 10.1001/jamanetworkopen.2020.37748.
- Schuemie MJ, Ryan PB, Pratt N, Chen R, You SC, Krumholz HM, Madigan D, Hripcsak G, Suchard MA. Erratum to: Large-Scale Evidence Generation and Evaluation across a Network of Databases (LEGEND): Assessing Validity Using Hypertension as a Case Study. Journal Of The American Medical Informatics Association : JAMIA 2021, 28: 196. PMID: 33099616, PMCID: PMC7810446, DOI: 10.1093/jamia/ocaa256.
- Sikka R, Lincoln AE, Adamson BJS, Epstein JA, Krumholz HM. What's Important: Reopening Lessons from the Big Leagues' Experiences with COVID-19. The Journal Of Bone And Joint Surgery. American Volume 2021, 103: 1-3. PMID: 33196503, DOI: 10.2106/JBJS.20.01894.
- Angraal S, Zachariah AG, Raaisa R, Khera R, Rao P, Krumholz HM, Spertus JA. Evaluation of Internet-Based Crowdsourced Fundraising to Cover Health Care Costs in the United States. JAMA Network Open 2021, 4: e2033157. PMID: 33427882, PMCID: PMC7801937, DOI: 10.1001/jamanetworkopen.2020.33157.
- Faust JS, Shah SB, Du C, Li SX, Lin Z, Krumholz HM. Suicide Deaths During the COVID-19 Stay-at-Home Advisory in Massachusetts, March to May 2020. JAMA Network Open 2021, 4: e2034273. PMID: 33475750, PMCID: PMC7821026, DOI: 10.1001/jamanetworkopen.2020.34273.
- Zinoviev R, Krumholz HM, Pirruccio K, Forman H. Association of Graduate Medical Education With Hospital Performance and Patient Outcomes. JAMA Network Open 2021, 4: e2034196. PMID: 33507257, PMCID: PMC7844596, DOI: 10.1001/jamanetworkopen.2020.34196.
- Labrosciano C, Horton D, Air T, Tavella R, Beltrame JF, Zeitz CJ, Krumholz HM, Adams RJ, Scott IA, Gallagher M, Hossain S, Hariharaputhiran S, Ranasinghe I. Frequency, trends and institutional variation in 30-day all-cause mortality and unplanned readmissions following hospitalisation for heart failure in Australia and New Zealand. European Journal Of Heart Failure 2021, 23: 31-40. PMID: 33094886, DOI: 10.1002/ejhf.2030.
- Dodson JA, Hajduk AM, Murphy TE, Geda M, Krumholz HM, Tsang S, Nanna MG, Tinetti ME, Ouellet G, Sybrant D, Gill TM, Chaudhry SI. 180-day readmission risk model for older adults with acute myocardial infarction: the SILVER-AMI study. Open Heart 2021, 8 PMID: 33452007, PMCID: PMC7813425, DOI: 10.1136/openhrt-2020-001442.
- McPadden J, Warner F, Young HP, Hurley NC, Pulk RA, Singh A, Durant TJS, Gong G, Desai N, Haimovich A, Taylor RA, Gunel M, Dela Cruz CS, Farhadian SF, Siner J, Villanueva M, Churchwell K, Hsiao A, Torre CJ, Velazquez EJ, Herbst RS, Iwasaki A, Ko AI, Mortazavi BJ, Krumholz HM, Schulz WL. Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection. PloS One 2021, 16: e0243291. PMID: 33788846, PMCID: PMC8011821, DOI: 10.1371/journal.pone.0243291.
- Hurley NC, Spatz ES, Krumholz HM, Jafari R, Mortazavi BJ. A Survey of Challenges and Opportunities in Sensing and Analytics for Risk Factors of Cardiovascular Disorders. ACM Transactions On Computing For Healthcare 2021, 2 PMID: 34337602, PMCID: PMC8320445, DOI: 10.1145/3417958.
- Harshfield EL, Pennells L, Schwartz JE, Willeit P, Kaptoge S, Bell S, Shaffer JA, Bolton T, Spackman S, Wassertheil-Smoller S, Kee F, Amouyel P, Shea SJ, Kuller LH, Kauhanen J, van Zutphen EM, Blazer DG, Krumholz H, Nietert PJ, Kromhout D, Laughlin G, Berkman L, Wallace RB, Simons LA, Dennison EM, Barr ELM, Meyer HE, Wood AM, Danesh J, Di Angelantonio E, Davidson KW. Association Between Depressive Symptoms and Incident Cardiovascular Diseases. JAMA 2020, 324: 2396-2405. PMID: 33320224, PMCID: PMC7739139, DOI: 10.1001/jama.2020.23068.
- Mszar R, Mahajan S, Valero-Elizondo J, Yahya T, Sharma R, Grandhi GR, Khera R, Virani SS, Lichtman J, Khan SU, Cainzos-Achirica M, Vahidy FS, Krumholz HM, Nasir K. Association Between Sociodemographic Determinants and Disparities in Stroke Symptom Awareness Among US Young Adults. Stroke; A Journal Of Cerebral Circulation 2020, 51: 3552-3561. PMID: 33100188, DOI: 10.1161/STROKEAHA.120.031137.
- Desai NR, Krumholz HM. From Reactivity to Proactivity: On the Path to Pre-Empting Heart Failure Hospitalizations. JACC. Heart Failure 2020, 8: 1035-1037. PMID: 33189634, DOI: 10.1016/j.jchf.2020.09.007.
- Krumholz HM. Inflection Point: Ideas for Accelerating Breakthroughs and Improving Cardiovascular Health. Circulation. Cardiovascular Quality And Outcomes 2020, 13: e007615. PMID: 33200951, PMCID: PMC7742208, DOI: 10.1161/CIRCOUTCOMES.120.007615.
- Durant TJS, Jean RA, Huang C, Coppi A, Schulz WL, Geirsson A, Krumholz HM. Evaluation of a Risk Stratification Model Using Preoperative and Intraoperative Data for Major Morbidity or Mortality After Cardiac Surgical Treatment. JAMA Network Open 2020, 3: e2028361. PMID: 33284333, DOI: 10.1001/jamanetworkopen.2020.28361.
- Mahajan S, Feng F, Hu S, Lu Y, Gupta A, Murugiah K, Gao Y, Lu J, Liu J, Zheng X, Spatz ES, Zhang H, Krumholz HM, Li J. Assessment of Prevalence, Awareness, and Characteristics of Isolated Systolic Hypertension Among Younger and Middle-Aged Adults in China. JAMA Network Open 2020, 3: e209743. PMID: 33289843, PMCID: PMC7724558, DOI: 10.1001/jamanetworkopen.2020.9743.
- Mori M, Wang Y, Mahajan S, Geirsson A, Krumholz HM. Associations Between the Severity of Influenza Seasons and Mortality and Readmission Risks After Elective Surgical Aortic Valve Replacement and Coronary Artery Bypass Graft Surgery in Older Adults. JAMA Network Open 2020, 3: e2031078. PMID: 33355673, PMCID: PMC7758803, DOI: 10.1001/jamanetworkopen.2020.31078.
- Vaduganathan M, Butler J, Krumholz HM, Itchhaporia D, Stecker EC, Bhatt DL. Regulation of Cardiovascular Therapies During the COVID-19 Public Health Emergency. Journal Of The American College Of Cardiology 2020, 76: 2517-2521. PMID: 33213730, PMCID: PMC7669239, DOI: 10.1016/j.jacc.2020.09.594.
- Desai MM, Zogg CK, Ranasinghe I, Parzynski CS, Lin Z, Gorbaty M, Merrill A, Krumholz HM, Drye EE. Variation in Risk-standardized Rates and Causes of Unplanned Hospital Visits Within 7 Days of Hospital Outpatient Surgery. Annals Of Surgery 2020 PMID: 33214469, DOI: 10.1097/SLA.0000000000004627.
- Krumholz HM, Bloom T, Sever R, Rawlinson C, Inglis JR, Ross JS. Submissions and Downloads of Preprints in the First Year of medRxiv. JAMA 2020, 324: 1903-1905. PMID: 33170232, PMCID: PMC7656287, DOI: 10.1001/jama.2020.17529.
- Hsia RY, Krumholz H, Shen YC. Evaluation of STEMI Regionalization on Access, Treatment, and Outcomes Among Adults Living in Nonminority and Minority Communities. JAMA Network Open 2020, 3: e2025874. PMID: 33196809, PMCID: PMC7670311, DOI: 10.1001/jamanetworkopen.2020.25874.
- Bikdeli B, Chatterjee S, Kirtane AJ, Parikh SA, Andreozzi GM, Desai NR, Francese DP, Gibson CM, Piazza G, Goldhaber SZ, Eikelboom JW, Krumholz HM, Stone GW. Sulodexide versus Control and the Risk of Thrombotic and Hemorrhagic Events: Meta-Analysis of Randomized Trials. Seminars In Thrombosis And Hemostasis 2020, 46: 908-918. PMID: 33086402, DOI: 10.1055/s-0040-1716874.
- You SC, Rho Y, Bikdeli B, Kim J, Siapos A, Weaver J, Londhe A, Cho J, Park J, Schuemie M, Suchard MA, Madigan D, Hripcsak G, Gupta A, Reich CG, Ryan PB, Park RW, Krumholz HM. Association of Ticagrelor vs Clopidogrel With Net Adverse Clinical Events in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention. JAMA 2020, 324: 1640-1650. PMID: 33107944, PMCID: PMC7592033, DOI: 10.1001/jama.2020.16167.
- Pendyal A, Rothenberg C, Scofi JE, Krumholz HM, Safdar B, Dreyer RP, Venkatesh AK. National Trends in Emergency Department Care Processes for Acute Myocardial Infarction in the United States, 2005 to 2015. Journal Of The American Heart Association 2020, 9: e017208. PMID: 33047624, PMCID: PMC7763391, DOI: 10.1161/JAHA.120.017208.
- Mori M, Wang Y, Murugiah K, Khera R, Gupta A, Vallabhajosyula P, Masoudi FA, Geirsson A, Krumholz HM. Trends in Reoperative Coronary Artery Bypass Graft Surgery for Older Adults in the United States, 1998 to 2017. Journal Of The American Heart Association 2020, 9: e016980. PMID: 33045889, PMCID: PMC7763387, DOI: 10.1161/JAHA.120.016980.
- Zhong Q, Gao Y, Zheng X, Chen J, Masoudi FA, Lu Y, Feng Y, Hu S, Zhang Q, Huang C, Wang Y, Krumholz HM, Li X, Zhou Y. Geographic Variation in Process and Outcomes of Care for Patients With Acute Myocardial Infarction in China From 2001 to 2015. JAMA Network Open 2020, 3: e2021182. PMID: 33095248, PMCID: PMC7584924, DOI: 10.1001/jamanetworkopen.2020.21182.
- Schulz WL, Kvedar JC, Krumholz HM. Agile analytics to support rapid knowledge pipelines. NPJ Digital Medicine 2020, 3: 108. PMID: 33594176, DOI: 10.1038/s41746-020-00309-z.
- Zhang L, Hurley NC, Ibrahim B, Spatz E, Krumholz HM, Jafari R, Mortazavi BJ. Developing Personalized Models of Blood Pressure Estimation from Wearable Sensors Data Using Minimally-trained Domain Adversarial Neural Networks. Proceedings Of Machine Learning Research 2020, 126: 97-120. PMID: 33649743, PMCID: PMC7916101.
- Inan OT, Tenaerts P, Prindiville SA, Reynolds HR, Dizon DS, Cooper-Arnold K, Turakhia M, Pletcher MJ, Preston KL, Krumholz HM, Marlin BM, Mandl KD, Klasnja P, Spring B, Iturriaga E, Campo R, Desvigne-Nickens P, Rosenberg Y, Steinhubl SR, Califf RM. Digitizing clinical trials. NPJ Digital Medicine 2020, 3: 101. PMID: 33594216, DOI: 10.1038/s41746-020-0302-y.
- Sel K, Brown A, Jang H, Krumholz HM, Lu N, Jafari R. A Wrist-worn Respiration Monitoring Device using Bio-Impedance. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society. IEEE Engineering In Medicine And Biology Society. Annual International Conference 2020, 2020: 3989-3993. PMID: 33018874, DOI: 10.1109/EMBC44109.2020.9176367.
- Mori M, Khera R, Lin Z, Ross JS, Schulz W, Krumholz HM. The Promise of Big Data and Digital Solutions in Building a Cardiovascular Learning System: Opportunities and Barriers. Methodist DeBakey Cardiovascular Journal 2020, 16: 212-219. PMID: 33133357, PMCID: PMC7587314, DOI: 10.14797/mdcj-16-3-212.
- Annapureddy AR, Angraal S, Caraballo C, Grimshaw A, Huang C, Mortazavi BJ, Krumholz HM. The National Institutes of Health funding for clinical research applying machine learning techniques in 2017. NPJ Digital Medicine 2020, 3: 13. PMID: 33514844, DOI: 10.1038/s41746-020-0223-9.
- Kuntz RE, Antman EM, Califf RM, Ingelfinger JR, Krumholz HM, Ommaya A, Peterson ED, Ross JS, Waldstreicher J, Wang SV, Zarin DA, Whicher DM, Siddiqi SM, Lopez MH. Individual Patient-Level Data Sharing for Continuous Learning: A Strategy for Trial Data Sharing. NAM Perspectives 2019, 2019 PMID: 34532668, PMCID: PMC8406566, DOI: 10.31478/201906b.
- Krumholz HM, Wang K, Lin Z, Dharmarajan K, Horwitz LI, Ross JS, Drye EE, Bernheim SM, Normand ST. Hospital-Readmission Risk - Isolating Hospital Effects from Patient Effects. The New England Journal Of Medicine 2017, 377: 1055-1064. PMID: 28902587, PMCID: PMC5671772, DOI: 10.1056/NEJMsa1702321.
- Chaudhry SI, Mattera JA, Curtis JP, Spertus JA, Herrin J, Lin Z, Phillips CO, Hodshon BV, Cooper LS, Krumholz HM. Telemonitoring in patients with heart failure. The New England Journal Of Medicine 2010, 363: 2301-9. PMID: 21080835, PMCID: PMC3237394, DOI: 10.1056/NEJMoa1010029.
- Ross JS, Normand SL, Wang Y, Ko DT, Chen J, Drye EE, Keenan PS, Lichtman JH, Bueno H, Schreiner GC, Krumholz HM. Hospital volume and 30-day mortality for three common medical conditions. The New England Journal Of Medicine 2010, 362: 1110-8. PMID: 20335587, PMCID: PMC2880468, DOI: 10.1056/NEJMsa0907130.
- Krumholz HM, Lee TH. Redefining quality--implications of recent clinical trials. The New England Journal Of Medicine 2008, 358: 2537-9. PMID: 18539915, DOI: 10.1056/NEJMp0803740.
- Jackevicius CA, Tu JV, Ross JS, Ko DT, Krumholz HM. Use of ezetimibe in the United States and Canada. The New England Journal Of Medicine 2008, 358: 1819-28. PMID: 18375999, DOI: 10.1056/NEJMsa0801461.
- Nallamothu BK, Bradley EH, Krumholz HM. Time to treatment in primary percutaneous coronary intervention. The New England Journal Of Medicine 2007, 357: 1631-8. PMID: 17942875, DOI: 10.1056/NEJMra065985.
- Bradley EH, Herrin J, Wang Y, Barton BA, Webster TR, Mattera JA, Roumanis SA, Curtis JP, Nallamothu BK, Magid DJ, McNamara RL, Parkosewich J, Loeb JM, Krumholz HM. Strategies for reducing the door-to-balloon time in acute myocardial infarction. The New England Journal Of Medicine 2006, 355: 2308-20. PMID: 17101617, DOI: 10.1056/NEJMsa063117.
- Vaccarino V, Rathore SS, Wenger NK, Frederick PD, Abramson JL, Barron HV, Manhapra A, Mallik S, Krumholz HM. Sex and racial differences in the management of acute myocardial infarction, 1994 through 2002. The New England Journal Of Medicine 2005, 353: 671-82. PMID: 16107620, PMCID: PMC2805130, DOI: 10.1056/NEJMsa032214.
- Rathore SS, Wang Y, Krumholz HM. Sex-based differences in the effect of digoxin for the treatment of heart failure. The New England Journal Of Medicine 2002, 347: 1403-11. PMID: 12409542, DOI: 10.1056/NEJMoa021266.
- Wu WC, Rathore SS, Wang Y, Radford MJ, Krumholz HM. Blood transfusion in elderly patients with acute myocardial infarction. The New England Journal Of Medicine 2001, 345: 1230-6. PMID: 11680442, DOI: 10.1056/NEJMoa010615.
- Chen J, Rathore SS, Radford MJ, Wang Y, Krumholz HM. Racial differences in the use of cardiac catheterization after acute myocardial infarction. The New England Journal Of Medicine 2001, 344: 1443-9. PMID: 11346810, DOI: 10.1056/NEJM200105103441906.
- Vaccarino V, Parsons L, Every NR, Barron HV, Krumholz HM. Sex-based differences in early mortality after myocardial infarction. National Registry of Myocardial Infarction 2 Participants. The New England Journal Of Medicine 1999, 341: 217-25. PMID: 10413733, DOI: 10.1056/NEJM199907223410401.
- Chen J, Radford MJ, Wang Y, Marciniak TA, Krumholz HM. Do "America's Best Hospitals" perform better for acute myocardial infarction? The New England Journal Of Medicine 1999, 340: 286-92. PMID: 9920954, DOI: 10.1056/NEJM199901283400407.
- Radford MJ, Krumholz HM. Beta-blockers after myocardial infarction--for few patients, or many? The New England Journal Of Medicine 1998, 339: 551-3. PMID: 9709049, DOI: 10.1056/NEJM199808203390809.
- Krumholz HM. Cardiac procedures, outcomes, and accountability. The New England Journal Of Medicine 1997, 336: 1522-3. PMID: 9154775, DOI: 10.1056/NEJM199705223362111.
- Krumholz HM, Pasternak RC, Weinstein MC, Friesinger GC, Ridker PM, Tosteson AN, Goldman L. Cost effectiveness of thrombolytic therapy with streptokinase in elderly patients with suspected acute myocardial infarction. The New England Journal Of Medicine 1992, 327: 7-13. PMID: 1598117, DOI: 10.1056/NEJM199207023270102.
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