Gary Désir, MD
Biography
Gary V. Desir, MD, chair of internal medicine, has pursued his interest in kidney function and disease since earning his medical degree at Yale School of Medicine. The single-minded focus paid off in 2005 when Dr. Desir and fellow researchers discovered renalase, a kidney (renal) protein that plays a role in regulating cardiovascular function.
“A renal fellow and I were caring for patients suffering from kidney disease and cardiovascular-related complications,” Dr. Desir says. “That was the inspiration for looking into the connection between kidney and heart disease. And that search led us to the discovery of renalase.”
At Yale New Haven Hospital, Dr. Desir also serves as the chief of internal medicine. He continues to devote a significant amount of time to kidney research at his lab at the Yale School of Medicine, where he is the Paul B. Beeson Professor of Medicine. An advocate of diversity, Dr. Desir co-founded the Minority Organization for Retention and Expansion (MORE) group at the medical school, with a goal to increase faculty diversity and provide medical students with a growing social network.
Titles
- Vice Provost for Faculty Development and Diversity; Chair, Department of Internal Medicine; and Paul B. Beeson Professor of Medicine
- Affiliated Faculty, Yale Institute for Global Health
Education & Training
- Post-Doc AssociateYale School of Medicine (1988)
- FellowYale School of Medicine (1984)
- ResidentYale School of Medicine (1983)
- MDYale University, Cum Laude (1980)
Languages Spoken
- Kreyòl (Creole)
- English
- Français (French)
- Español (Spanish)
Additional Information
- Elected Member: American Clinical and Climatological Association (2019)
- Community Service Award: Southern Connecticut Black Nurses Association (2019)
- Trailblazer Award: Jamaican American Connection of Greater New Haven (2018)
- Ground breaker Award: Alpha Phi Alpha (2017)
- Chi Omicron Chapter, Omega Psi Phi Fraternity: Links Inc (2016)
- Cornell Scott Health Award,: Greater New Haven NAACP (2016)
- Health Promotion Award: North Atlantic Regional Conference, Alpha Kappa Alpha (2016)
- Member: Association of Professors of Medicine (2013)
- Citizen Of The Year: Chi Omicron Chapter, Omega Psi Phi Fraternity (2012)
- AB of Internal Medicine, Nephrology (1986)
- AB of Internal Medicine, Internal Medicine (1983)
- Wang Y, Jia H, Du M, Sun Y, Wang D, Hu G, Man Z, Chu C, Desir G, Safirstein R, Zheng X, Mu J. COMBINED EFFECTS OF CHILD AND ADULT ELEVATED BLOOD PRESSURE ON ADULT SUBCLINICAL KIDNEY DAMAGE AND ALBUMINURIA: A 36-YEAR PROSPECTIVE COHORT STUDY. Journal Of Hypertension 2024, 42: e204. DOI: 10.1097/01.hjh.0001021508.55729.ea.
- Safdar B, Sobiesk M, Bertsimas D, Nowroozpoor A, Deng Y, D’Onofrio G, Dziura J, El-Khoury J, Guo X, Simonov M, Taylor R, Wang M, Desir G. Renalase Identified by Machine Learning Methods as A Novel Independent Predictor of Mortality in Hospitalized Patients with COVID-19. Journal Of Biotechnology And Biomedicine 2024, 07 DOI: 10.26502/jbb.2642-91280139.
- Muniraj T, Desir G, Gorelick F, Guo X, Ciarleglio M, Deng Y, Jamidar P, Farrell J, Aslanian H, Laine L. Clinical predictive value of renalase in post-ERCP pancreatitis. Gastrointestinal Endoscopy 2023, 99: 822-825.e1. PMID: 38103747, DOI: 10.1016/j.gie.2023.12.020.
- Guo X, Blanc V, Davidson N, Velazquez H, Chen T, Moledina D, Moeckel G, Safirstein R, Desir G. APOBEC-1 deletion enhances cisplatin-induced acute kidney injury. Scientific Reports 2023, 13: 22255. PMID: 38097707, PMCID: PMC10721635, DOI: 10.1038/s41598-023-49575-3.
- Guo X, Velazquez H, Xu L, Cheng Z, Chen T, Tian Y, Bewersdorf J, Blanc V, Davidson N, Safirstein R, Desir G. mRNA Editing via the Apobec1 Gene Promotes Recovery from AKI. Journal Of The American Society Of Nephrology 2023, 34: 451-451. DOI: 10.1681/asn.20233411s1451b.
- Guo X, Chen R, Chen T, Safirstein R, Jonas E, Desir G. Renalase Ameliorates AKI by Altering Mitochondrial Function to Induce Cellular Repair Mechanisms. Journal Of The American Society Of Nephrology 2023, 34: 117-117. DOI: 10.1681/asn.20233411s1117b.
- Charkoftaki G, Aalizadeh R, Santos-Neto A, Tan W, Davidson E, Nikolopoulou V, Wang Y, Thompson B, Furnary T, Chen Y, Wunder E, Coppi A, Schulz W, Iwasaki A, Pierce R, Cruz C, Desir G, Kaminski N, Farhadian S, Veselkov K, Datta R, Campbell M, Thomaidis N, Ko A, Thompson D, Vasiliou V. An AI-powered patient triage platform for future viral outbreaks using COVID-19 as a disease model. Human Genomics 2023, 17: 80. PMID: 37641126, PMCID: PMC10463861, DOI: 10.1186/s40246-023-00521-4.
- Liu Y, Rajeevan H, Simonov M, Lee S, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Ortega H, Zaeh S, Gomez J, Cohn L, Gautam S, Chupp G. Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 3383-3390.e3. PMID: 37454926, PMCID: PMC10787810, DOI: 10.1016/j.jaip.2023.07.006.
- Wang Y, Zhao P, Chu C, Du M, Zhang X, Zou T, Hu G, Jia H, Liao Y, Ma Q, Wang D, Desir G, Delles C, Chen F, Mu J. ASSOCIATIONS OF LONG-TERM VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY WITH SUBCLINICAL KIDNEY DAMAGE AND ALBUMINURIA IN ADULTHOOD: A 30-YEAR PROSPECTIVE COHORT STUDY. Journal Of Hypertension 2023, 41: e14. DOI: 10.1097/01.hjh.0000939008.10123.b9.
- Liu Y, Rajeevan H, Simonov M, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Gomez J, Cohn L, Gautam S, Chupp G. Mortality Differences Among Patients With Airway Disease Hospitalized With COVID-19. 2023, a6297-a6297. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6297.
- Muniraj T, Desir G, Gorelick F, Guo X, Ciarleglio M, Deng Y, Jamidar P, Farrell J, Aslanian H, Laine L. Sa1408 PREDICTIVE VALUE OF RENALASE IN POST-ERCP PANCREATITIS. Gastroenterology 2023, 164: s-384-s-385. DOI: 10.1016/s0016-5085(23)01894-2.
- Wang M, Weiss F, Guo X, Kolodecik T, Bewersdorf J, Laine L, Lerch M, Desir G, Gorelick F. Plasma renalase levels are associated with the development of acute pancreatitis. Pancreatology 2023, 23: 158-162. PMID: 36697349, DOI: 10.1016/j.pan.2023.01.001.
- Nair G, Zhang J, Guo X, guerrera N, Wu X, Hu X, Gorelick F, Safirstein R, Giordano F, Young L, Desir G. Abstract 13764: Renalase Peptide Agonist Therapy Normalizes the Cardiac Response to Pressure Overload in Chronic Kidney Disease. Circulation 2022, 146: a13764-a13764. DOI: 10.1161/circ.146.suppl_1.13764.
- Guo X, Xu L, Velazquez H, Chen T, Blanc V, Davidson N, Moeckel G, Safirstein R, Desir G. Apobec-1 Limits Cisplatin and Ischemia-Reperfusion-Induced AKI. Journal Of The American Society Of Nephrology 2022, 33: 359-360. DOI: 10.1681/asn.20223311s1359e.
- Guo X, Chen R, Chen T, Moeckel G, Safirstein R, Jonas E, Desir G. Renalase Protects Renal Injury by Maintaining Mitochondrial Dynamic Homeostasis. Journal Of The American Society Of Nephrology 2022, 33: 359-359. DOI: 10.1681/asn.20223311s1359d.
- Chaurasia R, Salovey A, Guo X, Desir G, Vinetz JM. Vaccination With Leptospira interrogans PF07598 Gene Family-Encoded Virulence Modifying Proteins Protects Mice From Severe Leptospirosis and Reduces Bacterial Load in the Liver and Kidney. Frontiers In Cellular And Infection Microbiology 2022, 12: 926994. PMID: 35837473, PMCID: PMC9274288, DOI: 10.3389/fcimb.2022.926994.
- Wang Y, Zhao P, Chu C, Du MF, Zhang XY, Zou T, Hu GL, Zhou HW, Jia H, Liao YY, Chen C, Ma Q, Wang D, Yan Y, Sun Y, Wang KK, Niu ZJ, Zhang X, Man ZY, Wu YX, Wang L, Li HX, Zhang J, Li CH, Gao WH, Gao K, Lu WH, Desir GV, Delles C, Chen FY, Mu JJ. Associations of Long-Term Visit-to-Visit Blood Pressure Variability With Subclinical Kidney Damage and Albuminuria in Adulthood: a 30-Year Prospective Cohort Study. Hypertension 2022, 79: 1247-1256. PMID: 35360932, PMCID: PMC9093226, DOI: 10.1161/hypertensionaha.121.18658.
- Wang M, Silva T, Toothaker JM, McCourt BT, Shugrue C, Desir G, Gorelick F, Konnikova L. Renalase and its receptor, PMCA4b, are expressed in the placenta throughout the human gestation. Scientific Reports 2022, 12: 4953. PMID: 35322081, PMCID: PMC8943056, DOI: 10.1038/s41598-022-08817-6.
- Safdar B, Wang M, Guo X, Cha C, Chun HJ, Deng Y, Dziura J, El-Khoury JM, Gorelick F, Ko AI, Lee AI, Safirstein R, Simonov M, Zhou B, Desir GV. Association of renalase with clinical outcomes in hospitalized patients with COVID-19. PLOS ONE 2022, 17: e0264178. PMID: 35259186, PMCID: PMC8903289, DOI: 10.1371/journal.pone.0264178.
- Guo X, Jessel S, Qu R, Kluger Y, Chen TM, Hollander L, Safirstein R, Nelson B, Cha C, Bosenberg M, Jilaveanu LB, Rimm D, Rothlin CV, Kluger HM, Desir GV. Inhibition of renalase drives tumour rejection by promoting T cell activation. European Journal Of Cancer 2022, 165: 81-96. PMID: 35219026, PMCID: PMC8940682, DOI: 10.1016/j.ejca.2022.01.002.
- Wang Y, Chen C, Hu GL, Chu C, Zhang XY, Du MF, Zou T, Zhou Q, Liao YY, Ma Q, Wang KK, Sun Y, Wang D, Yan Y, Li Y, Jia H, Niu ZJ, Zhang X, Wang L, Man ZY, Gao WH, Li CH, Zhang J, Gao K, Li HX, Chang J, Desir GV, Lu WH, Mu JJ. Associations of Renalase With Blood Pressure and Hypertension in Chinese Adults. Frontiers In Cardiovascular Medicine 2022, 9: 800427. PMID: 35282385, PMCID: PMC8907541, DOI: 10.3389/fcvm.2022.800427.
- Guo X, Xu L, Velazquez H, Chen TM, Williams RM, Heller DA, Burtness B, Safirstein R, Desir GV. Kidney-Targeted Renalase Agonist Prevents Cisplatin-Induced Chronic Kidney Disease by Inhibiting Regulated Necrosis and Inflammation. Journal Of The American Society Of Nephrology 2022, 33: 342-356. PMID: 34921111, PMCID: PMC8819981, DOI: 10.1681/asn.2021040439.
- Desir GV. RENALASE: DISCOVERY, BIOLOGY, AND THERAPEUTIC APPLICATIONS. Transactions Of The American Clinical And Climatological Association 2022, 132: 117-125. PMID: 36196172, PMCID: PMC9480547.
- Guo X, Xu L, Chen T, Gorelick F, Desir G, Safirstein R. Heightened Innate Immune Response to COVID-19 Infection in CKD: Implications to Poorer Outcome During CKD. Journal Of The American Society Of Nephrology 2021, 32: 749-749. DOI: 10.1681/asn.20213210s1749c.
- Gao Y, Wang M, Guo X, Hu J, Chen TM, Finn S, Lacy J, Kunstman JW, Cha CH, Bellin MD, Robert ME, Desir GV, Gorelick FS. Renalase is a novel tissue and serological biomarker in pancreatic ductal adenocarcinoma. PLOS ONE 2021, 16: e0250539. PMID: 34587190, PMCID: PMC8480607, DOI: 10.1371/journal.pone.0250539.
- Wang SY, Takahashi T, Pine AB, Damsky WE, Simonov M, Zhang Y, Kieras E, Price CC, King BA, Siegel MD, Desir GV, Lee AI, Iwasaki A, Chun HJ. Challenges in interpreting cytokine data in COVID-19 affect patient care and management. PLOS Biology 2021, 19: e3001373. PMID: 34358229, PMCID: PMC8372945, DOI: 10.1371/journal.pbio.3001373.
- Pointer TC, Gorelick FS, Desir GV. Renalase: A Multi-Functional Signaling Molecule with Roles in Gastrointestinal Disease. Cells 2021, 10: 2006. PMID: 34440775, PMCID: PMC8391834, DOI: 10.3390/cells10082006.
- Guo X, Xu L, Velazquez H, Chen T, Williams R, Heller D, Safirstein R, Desir G. Kidney Targeted Renalase Agonist Peptide Rescues Severe Model of Cisplatin-Induced AKI and CKD. Journal Of The American Society Of Nephrology 2020, 31: 230-230. DOI: 10.1681/asn.20203110s1230b.
- Guo X, Velazquez H, Chen T, Blanc V, Davidson N, Safirstein R, Desir G. Apobec 1 Limits Cisplatin-Induced AKI by Regulating the Disposal of Pro-Ferroptotic Lipids. Journal Of The American Society Of Nephrology 2020, 31: 123-123. DOI: 10.1681/asn.20203110s1123d.
- Nair G, Yoo J, Gao Y, Desir G, Gorelick F, Farrell J, Foster G, Joshi N. Sa1154 ORGANOID-BASED PRECLINICAL MODELS RECAPITULATE RENALASE SIGNALING IN PANCREATIC DUCTAL ADENOCARCINOMA. Gastroenterology 2020, 158: s-293. DOI: 10.1016/s0016-5085(20)31426-8.
- Identification of Two Forms of Human Plasma Renalase, and Their Association With All-Cause MortalityChang J, Guo X, Rao V, Gromisch ES, Chung S, Kluger HM, Cha C, Gorelick F, Testani J, Safirstein R, Crowley S, Peixoto AJ, Desir GV. Identification of Two Forms of Human Plasma Renalase, and Their Association With All-Cause Mortality. Kidney International Reports 2019, 5: 362-368. PMID: 32154458, PMCID: PMC7056858, DOI: 10.1016/j.ekir.2019.12.002.
- Rao V, Guo X, Chang J, Peixoto A, Testani J, Desir G. MON-334 TWO FORMS OF RENALASE (BOUND AND FREE) IDENTIFIED IN HUMAN PLASMA BY A NEW ELISA. Kidney International Reports 2019, 4: s67. DOI: 10.1016/j.ekir.2019.05.180.
- Desir G, Chang J, Guo X, Gromisch E, Peixoto A. SAT-183 % FREE RENALASE IS ASSOCIATED WITH PROGRESSION OF CKD, AND IS AN INDEPENDENT PREDICTOR OF ALL CAUSE MORTALITY. Kidney International Reports 2019, 4: s84-s85. DOI: 10.1016/j.ekir.2019.05.217.
- Chung S, Nagar A, Kolodecik T, Shugrue C, Desir G, Gorelick F, Protiva P. Sa1354 – Sex and Age Disparities in Pancreatic Cancer Survival. Gastroenterology 2019, 156: s-324. DOI: 10.1016/s0016-5085(19)37641-3.
- Landau SI, Guo X, Velazquez H, Torres R, Olson E, Garcia-Milian R, Moeckel GW, Desir GV, Safirstein R. Regulated necrosis and failed repair in cisplatin-induced chronic kidney disease. Kidney International 2019, 95: 797-814. PMID: 30904067, PMCID: PMC6543531, DOI: 10.1016/j.kint.2018.11.042.
- Safdar B, Guo X, Johnson C, D'Onofrio G, Dziura J, Sinusas AJ, Testani J, Rao V, Desir G. Elevated renalase levels in patients with acute coronary microvascular dysfunction – A possible biomarker for ischemia. International Journal Of Cardiology 2019, 279: 155-161. PMID: 30630613, PMCID: PMC6482834, DOI: 10.1016/j.ijcard.2018.12.061.
- Desir GV, Churchwell KB. New chief of cardiovascular medicine at Yale School of Medicine. European Heart Journal 2018, 39: 1665-1665. PMID: 29762704, DOI: 10.1093/eurheartj/ehy197.
- Kolodecik TR, Reed AM, Date K, Shugrue C, Patel V, Chung SL, Desir GV, Gorelick FS. The serum protein renalase reduces injury in experimental pancreatitis. Journal Of Biological Chemistry 2017, 292: 21047-21059. PMID: 29042438, PMCID: PMC5743078, DOI: 10.1074/jbc.m117.789776.
- Wang Y, Safirstein R, Velazquez H, Guo X, Hollander L, Chang J, Chen T, Mu J, Desir GV. Extracellular renalase protects cells and organs by outside‐in signalling. Journal Of Cellular And Molecular Medicine 2017, 21: 1260-1265. PMID: 28238213, PMCID: PMC5487909, DOI: 10.1111/jcmm.13062.
- Hollander L, Guo X, Velazquez H, Chang J, Safirstein R, Kluger H, Cha C, Desir G. Renalase Expression by Melanoma and Tumor-Associated Macrophages Promotes Tumor Growth through a STAT3-Mediated Mechanism. Cancer Research 2016, 76: 3884-3894. PMID: 27197188, PMCID: PMC5031238, DOI: 10.1158/0008-5472.can-15-1524.
- Giordano FJ, Wang Y, Desir GV. A Remote Role for Renalase. EBioMedicine 2016, 9: 27-28. PMID: 27374133, PMCID: PMC4972559, DOI: 10.1016/j.ebiom.2016.06.034.
- Guo X, Hollander L, MacPherson D, Wang L, Velazquez H, Chang J, Safirstein R, Cha C, Gorelick F, Desir GV. Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer. Scientific Reports 2016, 6: 22996. PMID: 26972355, PMCID: PMC4789641, DOI: 10.1038/srep22996.
- Qi C, Wang L, Zhang M, Shao X, Chang X, Fan Z, Cao Q, Mou S, Wang Q, Yan Y, Desir G, Ni Z. Serum Renalase Levels Correlate with Disease Activity in Lupus Nephritis. PLOS ONE 2015, 10: e0139627. PMID: 26431044, PMCID: PMC4592194, DOI: 10.1371/journal.pone.0139627.
- Torres R, Velazquez H, Chang JJ, Levene MJ, Moeckel G, Desir GV, Safirstein R. Three-Dimensional Morphology by Multiphoton Microscopy with Clearing in a Model of Cisplatin-Induced CKD. Journal Of The American Society Of Nephrology 2015, 27: 1102-1112. PMID: 26303068, PMCID: PMC4814184, DOI: 10.1681/asn.2015010079.
- Quelhas-Santos J, Sampaio-Maia B, Remião F, Serrão P, Soares-Silva I, Desir G, Pestana M. Assessment of Renalase Activity on Catecholamines Degradation. Hypertension Journal 2015, 7: 14-18. DOI: 10.2174/1876526201507010014.
- Wang L, Velazquez H, Chang J, Safirstein R, Desir GV. Identification of a Receptor for Extracellular Renalase. PLOS ONE 2015, 10: e0122932. PMID: 25906147, PMCID: PMC4407985, DOI: 10.1371/journal.pone.0122932.
- Quelhas-Santos J, Serrão MP, Soares-Silva I, Fernandes-Cerqueira C, Simões-Silva L, Pinho MJ, Remião F, Sampaio-Maia B, Desir GV, Pestana M. Renalase regulates peripheral and central dopaminergic activities. American Journal Of Physiology. Renal Physiology 2014, 308: f84-f91. PMID: 25411385, PMCID: PMC4338928, DOI: 10.1152/ajprenal.00274.2014.
- Guo X, Wang L, Velazquez H, Safirstein R, Desir GV. Renalase. Current Opinion In Nephrology & Hypertension 2014, 23: 513-518. PMID: 24992568, PMCID: PMC4383282, DOI: 10.1097/mnh.0000000000000044.
- Wang L, Velazquez H, Moeckel G, Chang J, Ham A, Lee HT, Safirstein R, Desir GV. Renalase Prevents AKI Independent of Amine Oxidase Activity. Journal Of The American Society Of Nephrology 2014, 25: 1226-1235. PMID: 24511138, PMCID: PMC4033373, DOI: 10.1681/asn.2013060665.
- Desir G. Renalase A New Player in Catecholamine Metabolism. 2014, 65. DOI: 10.1016/b978-0-12-800044-1.00057-x.
- Desir GV, Peixoto AJ. Renalase in hypertension and kidney disease. Nephrology Dialysis Transplantation 2013, 29: 22-28. PMID: 24137013, DOI: 10.1093/ndt/gft083.
- Sizova D, Velazquez H, Sampaio-Maia B, Quelhas-Santos J, Pestana M, Desir GV. Renalase regulates renal dopamine and phosphate metabolism. American Journal Of Physiology. Renal Physiology 2013, 305: f839-f844. PMID: 23863468, PMCID: PMC3761288, DOI: 10.1152/ajprenal.00616.2012.
- Desir G, Wang L, Velazquez H, Moeckel G, Safirstein R. Renalase protects against cisplatin acute kidney injury in mice. The FASEB Journal 2013, 27: 910.7-910.7. DOI: 10.1096/fasebj.27.1_supplement.910.7.
- Lee HT, Kim JY, Kim M, Wang P, Tang L, Baroni S, D’Agati V, Desir GV. Renalase Protects against Ischemic AKI. Journal Of The American Society Of Nephrology 2013, 24: 445-455. PMID: 23393318, PMCID: PMC3582209, DOI: 10.1681/asn.2012090943.
- Peixoto AJ, Orias M, Desir GV. Does Kidney Disease Cause Hypertension? Current Hypertension Reports 2013, 15: 89-94. PMID: 23344662, DOI: 10.1007/s11906-013-0327-6.
- Desir GV, Wang L, Peixoto AJ. Human renalase: a review of its biology, function, and implications for hypertension. International Journal Of Cardiology Cardiovascular Risk And Prevention 2012, 6: 417-426. PMID: 23107895, DOI: 10.1016/j.jash.2012.09.002.
- Desir GV, Tang L, Wang P, Li G, Sampaio‐Maia B, Quelhas‐Santos J, Pestana M, Velazquez H. Renalase Lowers Ambulatory Blood Pressure by Metabolizing Circulating Adrenaline. Journal Of The American Heart Association 2012, 1: e002634. PMID: 23130169, PMCID: PMC3487338, DOI: 10.1161/jaha.112.002634.
- Desir G. The Author Replies:. Kidney International 2011, 79: 1380-1381. DOI: 10.1038/ki.2011.91.
- QuelhasSantos J, Serrão P, FernandesCerqueira C, Silva L, SoaresSilva I, Sizova D, SampaioMaia B, Desir G, Pestana M. RENAL DOPAMINERGIC ACTIVITY IS INCREASED IN THE RENALASE KNOCKOUT MOUSE MODEL. Journal Of Hypertension 2011, 29: e103. DOI: 10.1097/00004872-201106001-00251.
- Desir G. Novel insights into the physiology of renalase and its role in hypertension and heart disease. Pediatric Nephrology 2011, 27: 719-725. PMID: 21424526, DOI: 10.1007/s00467-011-1828-7.
- Weinman EJ, Biswas R, Steplock D, Wang P, Lau YS, Desir GV, Shenolikar S. Increased renal dopamine and acute renal adaptation to a high-phosphate diet. American Journal Of Physiology. Renal Physiology 2011, 300: f1123-f1129. PMID: 21325500, PMCID: PMC3094044, DOI: 10.1152/ajprenal.00744.2010.
- Desir GV. Role of renalase in the regulation of blood pressure and the renal dopamine system. Current Opinion In Nephrology & Hypertension 2011, 20: 31-36. PMID: 21099685, DOI: 10.1097/mnh.0b013e3283412721.
- Wu Y, Xu J, Velazquez H, Wang P, Li G, Liu D, Sampaio-Maia B, Quelhas-Santos J, Russell K, Russell R, Flavell RA, Pestana M, Giordano F, Desir GV. Renalase deficiency aggravates ischemic myocardial damage. Kidney International 2010, 79: 853-860. PMID: 21178975, DOI: 10.1038/ki.2010.488.
- Farzaneh-Far R, Desir GV, Na B, Schiller NB, Whooley MA. A Functional Polymorphism in Renalase (Glu37Asp) Is Associated with Cardiac Hypertrophy, Dysfunction, and Ischemia: Data from the Heart and Soul Study. PLOS ONE 2010, 5: e13496. PMID: 20975995, PMCID: PMC2958117, DOI: 10.1371/journal.pone.0013496.
- Reilly RF, Peixoto AJ, Desir GV. The Evidence-Based Use of Thiazide Diuretics in Hypertension and Nephrolithiasis. Clinical Journal Of The American Society Of Nephrology 2010, 5: 1893-1903. PMID: 20798254, DOI: 10.2215/cjn.04670510.
- Hennebry SC, Eikelis N, Socratous F, Desir G, Lambert G, Schlaich M. Renalase, a novel soluble FAD-dependent protein, is synthesized in the brain and peripheral nerves. Molecular Psychiatry 2010, 15: 234-236. PMID: 20168325, DOI: 10.1038/mp.2009.74.
- Desir G. Role of Novel Biomarkers in Chronic Kidney Disease: Renalase. 2010, 309-316. DOI: 10.1007/978-88-470-1463-3_24.
- Knauf F, Desir GV, Perazella MA. A Case of Extreme Hemodynamic Lability and Hypocalcemia. The American Journal Of The Medical Sciences 2009, 338: 241-244. PMID: 19590425, DOI: 10.1097/maj.0b013e3181a66af1.
- Desir GV. Regulation of blood pressure and cardiovascular function by renalase. Kidney International 2009, 76: 366-370. PMID: 19471322, DOI: 10.1038/ki.2009.169.
- Desir GV. Renalase deficiency in chronic kidney disease, and its contribution to hypertension and cardiovascular disease. Current Opinion In Nephrology & Hypertension 2008, 17: 181-185. PMID: 18277152, DOI: 10.1097/mnh.0b013e3282f521ba.
- Li G, Xu J, Wang P, Velazquez H, Li Y, Wu Y, Desir GV. Catecholamines Regulate the Activity, Secretion, and Synthesis of Renalase. Circulation 2008, 117: 1277-1282. PMID: 18299506, DOI: 10.1161/circulationaha.107.732032.
- Li Y, Wang P, Xu J, Gorelick F, Yamazaki H, Andrews N, Desir GV. Regulation of insulin secretion and GLUT4 trafficking by the calcium sensor synaptotagmin VII. Biochemical And Biophysical Research Communications 2007, 362: 658-664. PMID: 17720139, PMCID: PMC2194288, DOI: 10.1016/j.bbrc.2007.08.023.
- Xu J, Desir GV. Renalase, a new renal hormone: its role in health and disease. Current Opinion In Nephrology & Hypertension 2007, 16: 373-378. PMID: 17565281, DOI: 10.1097/mnh.0b013e3281bd8877.
- Desir GV. Renalase is a novel renal hormone that regulates cardiovascular function. International Journal Of Cardiology Cardiovascular Risk And Prevention 2007, 1: 99-103. PMID: 20409839, DOI: 10.1016/j.jash.2006.12.001.
- Li Y, Wang P, Xu J, Desir GV. Voltage-gated potassium channel Kv1.3 regulates GLUT4 trafficking to the plasma membrane via a Ca2+-dependent mechanism. American Journal Of Physiology - Cell Physiology 2006, 290: c345-c351. PMID: 16403947, DOI: 10.1152/ajpcell.00091.2005.
- J X, G L, P W, H V, X Y, Y L, Y W, A P, S C, GV D. Kidney and Blood Pressure—The Story Unfolds Renalase Is a Novel, Soluble Monoamine Oxidase That Regulates Cardiac Function and Blood Pressure. J Clin Invest. Journal Of The American Society Of Nephrology 2005, 16: 2521-2527. DOI: 10.1681/asn.2005070751.
- Desir GV. Kv1.3 potassium channel blockade as an approach to insulin resistance. Expert Opinion On Therapeutic Targets 2005, 9: 571-579. PMID: 15948674, DOI: 10.1517/14728222.9.3.571.
- Xu J, Li G, Wang P, Velazquez H, Yao X, Li Y, Wu Y, Peixoto A, Crowley S, Desir GV. Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. Journal Of Clinical Investigation 2005, 115: 1275-1280. PMID: 15841207, PMCID: PMC1074681, DOI: 10.1172/jci24066.
- Hebert SC, Desir G, Giebisch G, Wang W. Molecular Diversity and Regulation of Renal Potassium Channels. Physiological Reviews 2005, 85: 319-371. PMID: 15618483, PMCID: PMC2838721, DOI: 10.1152/physrev.00051.2003.
- Xu J, Wang P, Li Y, Li G, Kaczmarek LK, Wu Y, Koni PA, Flavell RA, Desir GV. The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 3112-3117. PMID: 14981264, PMCID: PMC365752, DOI: 10.1073/pnas.0308450100.
- Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS. International Union of Pharmacology. XLI. Compendium of Voltage-Gated Ion Channels: Potassium Channels. Pharmacological Reviews 2003, 55: 583-586. PMID: 14657415, DOI: 10.1124/pr.55.4.9.
- Xu J, Koni PA, Wang P, Li G, Kaczmarek L, Wu Y, Li Y, Flavell RA, Desir GV. The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight. Human Molecular Genetics 2003, 12: 551-559. PMID: 12588802, DOI: 10.1093/hmg/ddg049.
- Yao X, Tian S, Chan HY, Biemesderfer D, Desir GV. Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule. Journal Of The American Society Of Nephrology 2002, 13: 2831-9. PMID: 12444201, DOI: 10.1097/01.asn.0000036866.37886.c5.
- Segal AS, Hayslett JP, Desir GV. On the natriuretic effect of verapamil: inhibition of ENaC and transepithelial sodium transport. American Journal Of Physiology. Renal Physiology 2002, 283: f765-f770. PMID: 12217868, DOI: 10.1152/ajprenal.00253.2001.
- Tian S, Liu W, Wu Y, Rafi H, Segal AS, Desir GV. Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel β-subunit. American Journal Of Physiology. Renal Physiology 2002, 283: f142-f149. PMID: 12060596, DOI: 10.1152/ajprenal.00258.2001.
- Velázquez H, Silva T, Andújar E, Desir G, Ellison D, Greger R. The distal convoluted tubule of rabbit kidney does not express a functional sodium channel. American Journal Of Physiology. Renal Physiology 2001, 280: f530-f539. PMID: 11181416, DOI: 10.1152/ajprenal.2001.280.3.f530.
- Lang R, Lee G, Liu W, Tian S, Rafi H, Orias M, Segal A, Desir G. KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels. American Journal Of Physiology. Renal Physiology 2000, 278: f1013-f1021. PMID: 10836990, DOI: 10.1152/ajprenal.2000.278.6.f1013.
- Yao X, Liu W, Tian S, Rafi H, Segal A, Desir G. Close Association of the N Terminus of Kv1.3 with the Pore Region*. Journal Of Biological Chemistry 2000, 275: 10859-10863. PMID: 10753881, DOI: 10.1074/jbc.275.15.10859.
- Kunchaparty S, Palcso M, Berkman J, Velázquez H, Desir G, Bernstein P, Reilly R, Ellison D. Defective processing and expression of thiazide-sensitive Na-Cl cotransporter as a cause of Gitelman’s syndrome. American Journal Of Physiology 1999, 277: f643-f649. PMID: 10516289, DOI: 10.1152/ajprenal.1999.277.4.f643.
- Segal A, Yao X, Desir G. The T0 Domain of Rabbit KV1.3 Regulates Steady State Channel Protein Level. Biochemical And Biophysical Research Communications 1999, 254: 54-64. PMID: 9920732, DOI: 10.1006/bbrc.1998.9801.
- Yao X, Huang Y, Kwan H, Chan P, Desir G. Characterization of a Regulatory Region in the N-Terminus of Rabbit Kv1.3 Volume249,Number 2 (1998), pages 492–498:. Biochemical And Biophysical Research Communications 1998, 252: 284. DOI: 10.1006/bbrc.1998.9627.
- Velázquez H, Náray-Fejes-Tóth A, Silva T, Andújar E, Reilly RF, Desir GV, Ellison DH. Rabbit distal convoluted tubule coexpresses NaCl cotransporter and 11β-hydroxysteroid dehydrogenase II mRNA. Kidney International 1998, 54: 464-472. PMID: 9690213, DOI: 10.1046/j.1523-1755.1998.00036.x.
- Yao X, Huang Y, Kwan HY, Chan P, Segal AS, Desir G. Characterization of a Regulatory Region in the N-Terminus of Rabbit Kv1.3. Biochemical And Biophysical Research Communications 1998, 249: 492-498. PMID: 9712724, DOI: 10.1006/bbrc.1998.9122.
- Orias M, Velázquez H, Tung F, Lee G, Desir G. Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments. American Journal Of Physiology 1997, 273: f663-f666. PMID: 9362344, DOI: 10.1152/ajprenal.1997.273.4.f663.
- Orias M, Bray-Ward P, Curran M, Keating M, Desir G. Genomic Localization of the Human Gene for KCNA10, a cGMP-Activated K Channel. Genomics 1997, 42: 33-37. PMID: 9177773, DOI: 10.1006/geno.1997.4712.
- Yao X, Liu Y, Tung F, Desir GV. Genomic structure and regulation of Kcn1, a cGMP-gated potassium channel. American Journal Of Physiology 1996, 271: f37-f41. PMID: 8760241, DOI: 10.1152/ajprenal.1996.271.1.f37.
- Yao X, Chang AY, Boulpaep EL, Segal AS, Desir GV. Molecular cloning of a glibenclamide-sensitive, voltage-gated potassium channel expressed in rabbit kidney. Journal Of Clinical Investigation 1996, 97: 2525-2533. PMID: 8647945, PMCID: PMC507338, DOI: 10.1172/jci118700.
- Yao X, Segal AS, Welling P, Zhang X, McNicholas CM, Engel D, Boulpaep EL, Desir GV. Primary structure and functional expression of a cGMP-gated potassium channel. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 11711-11715. PMID: 8524834, PMCID: PMC40472, DOI: 10.1073/pnas.92.25.11711.
- Desir G. Molecular characterization of voltage and cyclic nucleotide-gated potassium channels in kidney. Kidney International 1995, 48: 1031-1035. PMID: 8569064, DOI: 10.1038/ki.1995.386.
- Desir G. The structure, regulation and pathophysiology of potassium channels. Current Opinion In Nephrology & Hypertension 1995, 4: 402-405. PMID: 8564442, DOI: 10.1097/00041552-199509000-00005.
- Desir G. Molecular Physiology of a Novel Cgmp-Gated Potassium Channel. 1995, 9: 237-245. DOI: 10.1007/978-94-011-0117-2_27.
- Desir GV, Velazquez H. Identification of a novel K-channel gene (KC22) that is highly expressed in distal tubule of rabbit kidney. American Journal Of Physiology 1993, 264: f128-f133. PMID: 7679255, DOI: 10.1152/ajprenal.1993.264.1.f128.
- Ellison DH, Biemesderfer D, Morrisey J, Lauring J, Desir GV. Immunocytochemical characterization of the high-affinity thiazide diuretic receptor in rabbit renal cortex. American Journal Of Physiology 1993, 264: f141-f148. PMID: 8430824, DOI: 10.1152/ajprenal.1993.264.1.f141.
- Desir G. Molecular physiology of renal potassium channels. Seminars In Nephrology 1992, 12: 531-40. PMID: 1475548.
- Inhibition of Ca-activated K+ channels from renal microvillus membrane vesicles by amiloride analogsZweifach A, Desir G, Aronson P, Giebisch G. Inhibition of Ca-activated K+ channels from renal microvillus membrane vesicles by amiloride analogs. The Journal Of Membrane Biology 1992, 128: 115-122. PMID: 1501239, DOI: 10.1007/bf00231884.
- Desir GV, Hamlin HA, Puente E, Reilly RF, Hildebrandt F, Igarashi P. Isolation of putative voltage-gated epithelial K-channel isoforms from rabbit kidney and LLC-PK1 cells. American Journal Of Physiology 1992, 262: f151-f157. PMID: 1733291, DOI: 10.1152/ajprenal.1992.262.1.f151.
- Ellison D, Morrisey J, Desir G. Solubilization and partial purification of the thiazide diuretic receptor from rabbit renal cortex. Biochimica Et Biophysica Acta 1991, 1069: 241-249. PMID: 1932064, DOI: 10.1016/0005-2736(91)90131-q.
- Reconstitution and partial purification of an amiloride-sensitive, cation channel from rabbit kidneyDesir G. Reconstitution and partial purification of an amiloride-sensitive, cation channel from rabbit kidney. Biochimica Et Biophysica Acta 1991, 1067: 38-42. PMID: 1868102, DOI: 10.1016/0005-2736(91)90023-2.
- Zweifach A, Desir GV, Aronson PS, Giebisch GH. A Ca-activated K channel from rabbit renal brush-border membrane vesicles in planar lipid bilayers. American Journal Of Physiology 1991, 261: f187-f196. PMID: 1713419, DOI: 10.1152/ajprenal.1991.261.1.f187.
- Desir GV, Cragoe EJ, Aronson PS. High affinity binding of amiloride analogs at an internal site in renal microvillus membrane vesicles. Journal Of Biological Chemistry 1991, 266: 2267-2271. PMID: 1846621, DOI: 10.1016/s0021-9258(18)52238-9.
- Desir G, Bia M, Lange R, Smith E, Flye W, Kashgarian M, Schiff M, Ezekowitz M. The Clinical Utility of Indium-111 Labeled Platelet Scintigraphy in the Diagnoses of Renal Transplant Rejection. 1990, 264-277. DOI: 10.1007/978-94-009-0581-8_24.
- Bia M, Desir G, Ezekowitz M, Lange R, Smith E, Kashgarian M, Schiff M. 568 Detection of Acute Allograft Rejection by Indium-111 Labeled Platelet Scintigraphy in Renal Transplant Patients. Journal Of Urology 1987, 137: 245a. DOI: 10.1016/s0022-5347(17)75718-7.
- Desir G, Bia MJ, Lange RC, Smith EO, Kashgarian M, Flye W, Schiff M, Ezekowitz MD. Detection of acute allograft rejection by indium-111 labeled platelet scintigraphy in renal transplant patients. Transplantation Proceedings 1987, 19: 1677-80. PMID: 3547876.
- Desir G, Bratusch-Marrain P, DeFronzo R. Effect of hyperketonemia on renal ammonia excretion in man. Metabolism 1986, 35: 736-743. PMID: 3736414, DOI: 10.1016/0026-0495(86)90241-6.
- Desir G, Helman D, Herlich M, Turka L, Bia M. Haemophilus parainfluenzae Liver Abscess in a Recipient of a Renal Transplant Who Had Polycystic Disease. JAMA 1986, 255: 1878-1878. PMID: 3512876, DOI: 10.1001/jama.1986.03370140076015.
Biography
Gary V. Desir, MD, chair of internal medicine, has pursued his interest in kidney function and disease since earning his medical degree at Yale School of Medicine. The single-minded focus paid off in 2005 when Dr. Desir and fellow researchers discovered renalase, a kidney (renal) protein that plays a role in regulating cardiovascular function.
“A renal fellow and I were caring for patients suffering from kidney disease and cardiovascular-related complications,” Dr. Desir says. “That was the inspiration for looking into the connection between kidney and heart disease. And that search led us to the discovery of renalase.”
At Yale New Haven Hospital, Dr. Desir also serves as the chief of internal medicine. He continues to devote a significant amount of time to kidney research at his lab at the Yale School of Medicine, where he is the Paul B. Beeson Professor of Medicine. An advocate of diversity, Dr. Desir co-founded the Minority Organization for Retention and Expansion (MORE) group at the medical school, with a goal to increase faculty diversity and provide medical students with a growing social network.
Titles
- Vice Provost for Faculty Development and Diversity; Chair, Department of Internal Medicine; and Paul B. Beeson Professor of Medicine
- Affiliated Faculty, Yale Institute for Global Health
Education & Training
- Post-Doc AssociateYale School of Medicine (1988)
- FellowYale School of Medicine (1984)
- ResidentYale School of Medicine (1983)
- MDYale University, Cum Laude (1980)
Languages Spoken
- Kreyòl (Creole)
- English
- Français (French)
- Español (Spanish)
Additional Information
- Elected Member: American Clinical and Climatological Association (2019)
- Community Service Award: Southern Connecticut Black Nurses Association (2019)
- Trailblazer Award: Jamaican American Connection of Greater New Haven (2018)
- Ground breaker Award: Alpha Phi Alpha (2017)
- Chi Omicron Chapter, Omega Psi Phi Fraternity: Links Inc (2016)
- Cornell Scott Health Award,: Greater New Haven NAACP (2016)
- Health Promotion Award: North Atlantic Regional Conference, Alpha Kappa Alpha (2016)
- Member: Association of Professors of Medicine (2013)
- Citizen Of The Year: Chi Omicron Chapter, Omega Psi Phi Fraternity (2012)
- AB of Internal Medicine, Nephrology (1986)
- AB of Internal Medicine, Internal Medicine (1983)
- Wang Y, Jia H, Du M, Sun Y, Wang D, Hu G, Man Z, Chu C, Desir G, Safirstein R, Zheng X, Mu J. COMBINED EFFECTS OF CHILD AND ADULT ELEVATED BLOOD PRESSURE ON ADULT SUBCLINICAL KIDNEY DAMAGE AND ALBUMINURIA: A 36-YEAR PROSPECTIVE COHORT STUDY. Journal Of Hypertension 2024, 42: e204. DOI: 10.1097/01.hjh.0001021508.55729.ea.
- Safdar B, Sobiesk M, Bertsimas D, Nowroozpoor A, Deng Y, D’Onofrio G, Dziura J, El-Khoury J, Guo X, Simonov M, Taylor R, Wang M, Desir G. Renalase Identified by Machine Learning Methods as A Novel Independent Predictor of Mortality in Hospitalized Patients with COVID-19. Journal Of Biotechnology And Biomedicine 2024, 07 DOI: 10.26502/jbb.2642-91280139.
- Muniraj T, Desir G, Gorelick F, Guo X, Ciarleglio M, Deng Y, Jamidar P, Farrell J, Aslanian H, Laine L. Clinical predictive value of renalase in post-ERCP pancreatitis. Gastrointestinal Endoscopy 2023, 99: 822-825.e1. PMID: 38103747, DOI: 10.1016/j.gie.2023.12.020.
- Guo X, Blanc V, Davidson N, Velazquez H, Chen T, Moledina D, Moeckel G, Safirstein R, Desir G. APOBEC-1 deletion enhances cisplatin-induced acute kidney injury. Scientific Reports 2023, 13: 22255. PMID: 38097707, PMCID: PMC10721635, DOI: 10.1038/s41598-023-49575-3.
- Guo X, Velazquez H, Xu L, Cheng Z, Chen T, Tian Y, Bewersdorf J, Blanc V, Davidson N, Safirstein R, Desir G. mRNA Editing via the Apobec1 Gene Promotes Recovery from AKI. Journal Of The American Society Of Nephrology 2023, 34: 451-451. DOI: 10.1681/asn.20233411s1451b.
- Guo X, Chen R, Chen T, Safirstein R, Jonas E, Desir G. Renalase Ameliorates AKI by Altering Mitochondrial Function to Induce Cellular Repair Mechanisms. Journal Of The American Society Of Nephrology 2023, 34: 117-117. DOI: 10.1681/asn.20233411s1117b.
- Charkoftaki G, Aalizadeh R, Santos-Neto A, Tan W, Davidson E, Nikolopoulou V, Wang Y, Thompson B, Furnary T, Chen Y, Wunder E, Coppi A, Schulz W, Iwasaki A, Pierce R, Cruz C, Desir G, Kaminski N, Farhadian S, Veselkov K, Datta R, Campbell M, Thomaidis N, Ko A, Thompson D, Vasiliou V. An AI-powered patient triage platform for future viral outbreaks using COVID-19 as a disease model. Human Genomics 2023, 17: 80. PMID: 37641126, PMCID: PMC10463861, DOI: 10.1186/s40246-023-00521-4.
- Liu Y, Rajeevan H, Simonov M, Lee S, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Ortega H, Zaeh S, Gomez J, Cohn L, Gautam S, Chupp G. Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 3383-3390.e3. PMID: 37454926, PMCID: PMC10787810, DOI: 10.1016/j.jaip.2023.07.006.
- Wang Y, Zhao P, Chu C, Du M, Zhang X, Zou T, Hu G, Jia H, Liao Y, Ma Q, Wang D, Desir G, Delles C, Chen F, Mu J. ASSOCIATIONS OF LONG-TERM VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY WITH SUBCLINICAL KIDNEY DAMAGE AND ALBUMINURIA IN ADULTHOOD: A 30-YEAR PROSPECTIVE COHORT STUDY. Journal Of Hypertension 2023, 41: e14. DOI: 10.1097/01.hjh.0000939008.10123.b9.
- Liu Y, Rajeevan H, Simonov M, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Gomez J, Cohn L, Gautam S, Chupp G. Mortality Differences Among Patients With Airway Disease Hospitalized With COVID-19. 2023, a6297-a6297. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6297.
- Muniraj T, Desir G, Gorelick F, Guo X, Ciarleglio M, Deng Y, Jamidar P, Farrell J, Aslanian H, Laine L. Sa1408 PREDICTIVE VALUE OF RENALASE IN POST-ERCP PANCREATITIS. Gastroenterology 2023, 164: s-384-s-385. DOI: 10.1016/s0016-5085(23)01894-2.
- Wang M, Weiss F, Guo X, Kolodecik T, Bewersdorf J, Laine L, Lerch M, Desir G, Gorelick F. Plasma renalase levels are associated with the development of acute pancreatitis. Pancreatology 2023, 23: 158-162. PMID: 36697349, DOI: 10.1016/j.pan.2023.01.001.
- Nair G, Zhang J, Guo X, guerrera N, Wu X, Hu X, Gorelick F, Safirstein R, Giordano F, Young L, Desir G. Abstract 13764: Renalase Peptide Agonist Therapy Normalizes the Cardiac Response to Pressure Overload in Chronic Kidney Disease. Circulation 2022, 146: a13764-a13764. DOI: 10.1161/circ.146.suppl_1.13764.
- Guo X, Xu L, Velazquez H, Chen T, Blanc V, Davidson N, Moeckel G, Safirstein R, Desir G. Apobec-1 Limits Cisplatin and Ischemia-Reperfusion-Induced AKI. Journal Of The American Society Of Nephrology 2022, 33: 359-360. DOI: 10.1681/asn.20223311s1359e.
- Guo X, Chen R, Chen T, Moeckel G, Safirstein R, Jonas E, Desir G. Renalase Protects Renal Injury by Maintaining Mitochondrial Dynamic Homeostasis. Journal Of The American Society Of Nephrology 2022, 33: 359-359. DOI: 10.1681/asn.20223311s1359d.
- Chaurasia R, Salovey A, Guo X, Desir G, Vinetz JM. Vaccination With Leptospira interrogans PF07598 Gene Family-Encoded Virulence Modifying Proteins Protects Mice From Severe Leptospirosis and Reduces Bacterial Load in the Liver and Kidney. Frontiers In Cellular And Infection Microbiology 2022, 12: 926994. PMID: 35837473, PMCID: PMC9274288, DOI: 10.3389/fcimb.2022.926994.
- Wang Y, Zhao P, Chu C, Du MF, Zhang XY, Zou T, Hu GL, Zhou HW, Jia H, Liao YY, Chen C, Ma Q, Wang D, Yan Y, Sun Y, Wang KK, Niu ZJ, Zhang X, Man ZY, Wu YX, Wang L, Li HX, Zhang J, Li CH, Gao WH, Gao K, Lu WH, Desir GV, Delles C, Chen FY, Mu JJ. Associations of Long-Term Visit-to-Visit Blood Pressure Variability With Subclinical Kidney Damage and Albuminuria in Adulthood: a 30-Year Prospective Cohort Study. Hypertension 2022, 79: 1247-1256. PMID: 35360932, PMCID: PMC9093226, DOI: 10.1161/hypertensionaha.121.18658.
- Wang M, Silva T, Toothaker JM, McCourt BT, Shugrue C, Desir G, Gorelick F, Konnikova L. Renalase and its receptor, PMCA4b, are expressed in the placenta throughout the human gestation. Scientific Reports 2022, 12: 4953. PMID: 35322081, PMCID: PMC8943056, DOI: 10.1038/s41598-022-08817-6.
- Safdar B, Wang M, Guo X, Cha C, Chun HJ, Deng Y, Dziura J, El-Khoury JM, Gorelick F, Ko AI, Lee AI, Safirstein R, Simonov M, Zhou B, Desir GV. Association of renalase with clinical outcomes in hospitalized patients with COVID-19. PLOS ONE 2022, 17: e0264178. PMID: 35259186, PMCID: PMC8903289, DOI: 10.1371/journal.pone.0264178.
- Guo X, Jessel S, Qu R, Kluger Y, Chen TM, Hollander L, Safirstein R, Nelson B, Cha C, Bosenberg M, Jilaveanu LB, Rimm D, Rothlin CV, Kluger HM, Desir GV. Inhibition of renalase drives tumour rejection by promoting T cell activation. European Journal Of Cancer 2022, 165: 81-96. PMID: 35219026, PMCID: PMC8940682, DOI: 10.1016/j.ejca.2022.01.002.
- Wang Y, Chen C, Hu GL, Chu C, Zhang XY, Du MF, Zou T, Zhou Q, Liao YY, Ma Q, Wang KK, Sun Y, Wang D, Yan Y, Li Y, Jia H, Niu ZJ, Zhang X, Wang L, Man ZY, Gao WH, Li CH, Zhang J, Gao K, Li HX, Chang J, Desir GV, Lu WH, Mu JJ. Associations of Renalase With Blood Pressure and Hypertension in Chinese Adults. Frontiers In Cardiovascular Medicine 2022, 9: 800427. PMID: 35282385, PMCID: PMC8907541, DOI: 10.3389/fcvm.2022.800427.
- Guo X, Xu L, Velazquez H, Chen TM, Williams RM, Heller DA, Burtness B, Safirstein R, Desir GV. Kidney-Targeted Renalase Agonist Prevents Cisplatin-Induced Chronic Kidney Disease by Inhibiting Regulated Necrosis and Inflammation. Journal Of The American Society Of Nephrology 2022, 33: 342-356. PMID: 34921111, PMCID: PMC8819981, DOI: 10.1681/asn.2021040439.
- Desir GV. RENALASE: DISCOVERY, BIOLOGY, AND THERAPEUTIC APPLICATIONS. Transactions Of The American Clinical And Climatological Association 2022, 132: 117-125. PMID: 36196172, PMCID: PMC9480547.
- Guo X, Xu L, Chen T, Gorelick F, Desir G, Safirstein R. Heightened Innate Immune Response to COVID-19 Infection in CKD: Implications to Poorer Outcome During CKD. Journal Of The American Society Of Nephrology 2021, 32: 749-749. DOI: 10.1681/asn.20213210s1749c.
- Gao Y, Wang M, Guo X, Hu J, Chen TM, Finn S, Lacy J, Kunstman JW, Cha CH, Bellin MD, Robert ME, Desir GV, Gorelick FS. Renalase is a novel tissue and serological biomarker in pancreatic ductal adenocarcinoma. PLOS ONE 2021, 16: e0250539. PMID: 34587190, PMCID: PMC8480607, DOI: 10.1371/journal.pone.0250539.
- Wang SY, Takahashi T, Pine AB, Damsky WE, Simonov M, Zhang Y, Kieras E, Price CC, King BA, Siegel MD, Desir GV, Lee AI, Iwasaki A, Chun HJ. Challenges in interpreting cytokine data in COVID-19 affect patient care and management. PLOS Biology 2021, 19: e3001373. PMID: 34358229, PMCID: PMC8372945, DOI: 10.1371/journal.pbio.3001373.
- Pointer TC, Gorelick FS, Desir GV. Renalase: A Multi-Functional Signaling Molecule with Roles in Gastrointestinal Disease. Cells 2021, 10: 2006. PMID: 34440775, PMCID: PMC8391834, DOI: 10.3390/cells10082006.
- Guo X, Xu L, Velazquez H, Chen T, Williams R, Heller D, Safirstein R, Desir G. Kidney Targeted Renalase Agonist Peptide Rescues Severe Model of Cisplatin-Induced AKI and CKD. Journal Of The American Society Of Nephrology 2020, 31: 230-230. DOI: 10.1681/asn.20203110s1230b.
- Guo X, Velazquez H, Chen T, Blanc V, Davidson N, Safirstein R, Desir G. Apobec 1 Limits Cisplatin-Induced AKI by Regulating the Disposal of Pro-Ferroptotic Lipids. Journal Of The American Society Of Nephrology 2020, 31: 123-123. DOI: 10.1681/asn.20203110s1123d.
- Nair G, Yoo J, Gao Y, Desir G, Gorelick F, Farrell J, Foster G, Joshi N. Sa1154 ORGANOID-BASED PRECLINICAL MODELS RECAPITULATE RENALASE SIGNALING IN PANCREATIC DUCTAL ADENOCARCINOMA. Gastroenterology 2020, 158: s-293. DOI: 10.1016/s0016-5085(20)31426-8.
- Identification of Two Forms of Human Plasma Renalase, and Their Association With All-Cause MortalityChang J, Guo X, Rao V, Gromisch ES, Chung S, Kluger HM, Cha C, Gorelick F, Testani J, Safirstein R, Crowley S, Peixoto AJ, Desir GV. Identification of Two Forms of Human Plasma Renalase, and Their Association With All-Cause Mortality. Kidney International Reports 2019, 5: 362-368. PMID: 32154458, PMCID: PMC7056858, DOI: 10.1016/j.ekir.2019.12.002.
- Rao V, Guo X, Chang J, Peixoto A, Testani J, Desir G. MON-334 TWO FORMS OF RENALASE (BOUND AND FREE) IDENTIFIED IN HUMAN PLASMA BY A NEW ELISA. Kidney International Reports 2019, 4: s67. DOI: 10.1016/j.ekir.2019.05.180.
- Desir G, Chang J, Guo X, Gromisch E, Peixoto A. SAT-183 % FREE RENALASE IS ASSOCIATED WITH PROGRESSION OF CKD, AND IS AN INDEPENDENT PREDICTOR OF ALL CAUSE MORTALITY. Kidney International Reports 2019, 4: s84-s85. DOI: 10.1016/j.ekir.2019.05.217.
- Chung S, Nagar A, Kolodecik T, Shugrue C, Desir G, Gorelick F, Protiva P. Sa1354 – Sex and Age Disparities in Pancreatic Cancer Survival. Gastroenterology 2019, 156: s-324. DOI: 10.1016/s0016-5085(19)37641-3.
- Landau SI, Guo X, Velazquez H, Torres R, Olson E, Garcia-Milian R, Moeckel GW, Desir GV, Safirstein R. Regulated necrosis and failed repair in cisplatin-induced chronic kidney disease. Kidney International 2019, 95: 797-814. PMID: 30904067, PMCID: PMC6543531, DOI: 10.1016/j.kint.2018.11.042.
- Safdar B, Guo X, Johnson C, D'Onofrio G, Dziura J, Sinusas AJ, Testani J, Rao V, Desir G. Elevated renalase levels in patients with acute coronary microvascular dysfunction – A possible biomarker for ischemia. International Journal Of Cardiology 2019, 279: 155-161. PMID: 30630613, PMCID: PMC6482834, DOI: 10.1016/j.ijcard.2018.12.061.
- Desir GV, Churchwell KB. New chief of cardiovascular medicine at Yale School of Medicine. European Heart Journal 2018, 39: 1665-1665. PMID: 29762704, DOI: 10.1093/eurheartj/ehy197.
- Kolodecik TR, Reed AM, Date K, Shugrue C, Patel V, Chung SL, Desir GV, Gorelick FS. The serum protein renalase reduces injury in experimental pancreatitis. Journal Of Biological Chemistry 2017, 292: 21047-21059. PMID: 29042438, PMCID: PMC5743078, DOI: 10.1074/jbc.m117.789776.
- Wang Y, Safirstein R, Velazquez H, Guo X, Hollander L, Chang J, Chen T, Mu J, Desir GV. Extracellular renalase protects cells and organs by outside‐in signalling. Journal Of Cellular And Molecular Medicine 2017, 21: 1260-1265. PMID: 28238213, PMCID: PMC5487909, DOI: 10.1111/jcmm.13062.
- Hollander L, Guo X, Velazquez H, Chang J, Safirstein R, Kluger H, Cha C, Desir G. Renalase Expression by Melanoma and Tumor-Associated Macrophages Promotes Tumor Growth through a STAT3-Mediated Mechanism. Cancer Research 2016, 76: 3884-3894. PMID: 27197188, PMCID: PMC5031238, DOI: 10.1158/0008-5472.can-15-1524.
- Giordano FJ, Wang Y, Desir GV. A Remote Role for Renalase. EBioMedicine 2016, 9: 27-28. PMID: 27374133, PMCID: PMC4972559, DOI: 10.1016/j.ebiom.2016.06.034.
- Guo X, Hollander L, MacPherson D, Wang L, Velazquez H, Chang J, Safirstein R, Cha C, Gorelick F, Desir GV. Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer. Scientific Reports 2016, 6: 22996. PMID: 26972355, PMCID: PMC4789641, DOI: 10.1038/srep22996.
- Qi C, Wang L, Zhang M, Shao X, Chang X, Fan Z, Cao Q, Mou S, Wang Q, Yan Y, Desir G, Ni Z. Serum Renalase Levels Correlate with Disease Activity in Lupus Nephritis. PLOS ONE 2015, 10: e0139627. PMID: 26431044, PMCID: PMC4592194, DOI: 10.1371/journal.pone.0139627.
- Torres R, Velazquez H, Chang JJ, Levene MJ, Moeckel G, Desir GV, Safirstein R. Three-Dimensional Morphology by Multiphoton Microscopy with Clearing in a Model of Cisplatin-Induced CKD. Journal Of The American Society Of Nephrology 2015, 27: 1102-1112. PMID: 26303068, PMCID: PMC4814184, DOI: 10.1681/asn.2015010079.
- Quelhas-Santos J, Sampaio-Maia B, Remião F, Serrão P, Soares-Silva I, Desir G, Pestana M. Assessment of Renalase Activity on Catecholamines Degradation. Hypertension Journal 2015, 7: 14-18. DOI: 10.2174/1876526201507010014.
- Wang L, Velazquez H, Chang J, Safirstein R, Desir GV. Identification of a Receptor for Extracellular Renalase. PLOS ONE 2015, 10: e0122932. PMID: 25906147, PMCID: PMC4407985, DOI: 10.1371/journal.pone.0122932.
- Quelhas-Santos J, Serrão MP, Soares-Silva I, Fernandes-Cerqueira C, Simões-Silva L, Pinho MJ, Remião F, Sampaio-Maia B, Desir GV, Pestana M. Renalase regulates peripheral and central dopaminergic activities. American Journal Of Physiology. Renal Physiology 2014, 308: f84-f91. PMID: 25411385, PMCID: PMC4338928, DOI: 10.1152/ajprenal.00274.2014.
- Guo X, Wang L, Velazquez H, Safirstein R, Desir GV. Renalase. Current Opinion In Nephrology & Hypertension 2014, 23: 513-518. PMID: 24992568, PMCID: PMC4383282, DOI: 10.1097/mnh.0000000000000044.
- Wang L, Velazquez H, Moeckel G, Chang J, Ham A, Lee HT, Safirstein R, Desir GV. Renalase Prevents AKI Independent of Amine Oxidase Activity. Journal Of The American Society Of Nephrology 2014, 25: 1226-1235. PMID: 24511138, PMCID: PMC4033373, DOI: 10.1681/asn.2013060665.
- Desir G. Renalase A New Player in Catecholamine Metabolism. 2014, 65. DOI: 10.1016/b978-0-12-800044-1.00057-x.
- Desir GV, Peixoto AJ. Renalase in hypertension and kidney disease. Nephrology Dialysis Transplantation 2013, 29: 22-28. PMID: 24137013, DOI: 10.1093/ndt/gft083.
- Sizova D, Velazquez H, Sampaio-Maia B, Quelhas-Santos J, Pestana M, Desir GV. Renalase regulates renal dopamine and phosphate metabolism. American Journal Of Physiology. Renal Physiology 2013, 305: f839-f844. PMID: 23863468, PMCID: PMC3761288, DOI: 10.1152/ajprenal.00616.2012.
- Desir G, Wang L, Velazquez H, Moeckel G, Safirstein R. Renalase protects against cisplatin acute kidney injury in mice. The FASEB Journal 2013, 27: 910.7-910.7. DOI: 10.1096/fasebj.27.1_supplement.910.7.
- Lee HT, Kim JY, Kim M, Wang P, Tang L, Baroni S, D’Agati V, Desir GV. Renalase Protects against Ischemic AKI. Journal Of The American Society Of Nephrology 2013, 24: 445-455. PMID: 23393318, PMCID: PMC3582209, DOI: 10.1681/asn.2012090943.
- Peixoto AJ, Orias M, Desir GV. Does Kidney Disease Cause Hypertension? Current Hypertension Reports 2013, 15: 89-94. PMID: 23344662, DOI: 10.1007/s11906-013-0327-6.
- Desir GV, Wang L, Peixoto AJ. Human renalase: a review of its biology, function, and implications for hypertension. International Journal Of Cardiology Cardiovascular Risk And Prevention 2012, 6: 417-426. PMID: 23107895, DOI: 10.1016/j.jash.2012.09.002.
- Desir GV, Tang L, Wang P, Li G, Sampaio‐Maia B, Quelhas‐Santos J, Pestana M, Velazquez H. Renalase Lowers Ambulatory Blood Pressure by Metabolizing Circulating Adrenaline. Journal Of The American Heart Association 2012, 1: e002634. PMID: 23130169, PMCID: PMC3487338, DOI: 10.1161/jaha.112.002634.
- Desir G. The Author Replies:. Kidney International 2011, 79: 1380-1381. DOI: 10.1038/ki.2011.91.
- QuelhasSantos J, Serrão P, FernandesCerqueira C, Silva L, SoaresSilva I, Sizova D, SampaioMaia B, Desir G, Pestana M. RENAL DOPAMINERGIC ACTIVITY IS INCREASED IN THE RENALASE KNOCKOUT MOUSE MODEL. Journal Of Hypertension 2011, 29: e103. DOI: 10.1097/00004872-201106001-00251.
- Desir G. Novel insights into the physiology of renalase and its role in hypertension and heart disease. Pediatric Nephrology 2011, 27: 719-725. PMID: 21424526, DOI: 10.1007/s00467-011-1828-7.
- Weinman EJ, Biswas R, Steplock D, Wang P, Lau YS, Desir GV, Shenolikar S. Increased renal dopamine and acute renal adaptation to a high-phosphate diet. American Journal Of Physiology. Renal Physiology 2011, 300: f1123-f1129. PMID: 21325500, PMCID: PMC3094044, DOI: 10.1152/ajprenal.00744.2010.
- Desir GV. Role of renalase in the regulation of blood pressure and the renal dopamine system. Current Opinion In Nephrology & Hypertension 2011, 20: 31-36. PMID: 21099685, DOI: 10.1097/mnh.0b013e3283412721.
- Wu Y, Xu J, Velazquez H, Wang P, Li G, Liu D, Sampaio-Maia B, Quelhas-Santos J, Russell K, Russell R, Flavell RA, Pestana M, Giordano F, Desir GV. Renalase deficiency aggravates ischemic myocardial damage. Kidney International 2010, 79: 853-860. PMID: 21178975, DOI: 10.1038/ki.2010.488.
- Farzaneh-Far R, Desir GV, Na B, Schiller NB, Whooley MA. A Functional Polymorphism in Renalase (Glu37Asp) Is Associated with Cardiac Hypertrophy, Dysfunction, and Ischemia: Data from the Heart and Soul Study. PLOS ONE 2010, 5: e13496. PMID: 20975995, PMCID: PMC2958117, DOI: 10.1371/journal.pone.0013496.
- Reilly RF, Peixoto AJ, Desir GV. The Evidence-Based Use of Thiazide Diuretics in Hypertension and Nephrolithiasis. Clinical Journal Of The American Society Of Nephrology 2010, 5: 1893-1903. PMID: 20798254, DOI: 10.2215/cjn.04670510.
- Hennebry SC, Eikelis N, Socratous F, Desir G, Lambert G, Schlaich M. Renalase, a novel soluble FAD-dependent protein, is synthesized in the brain and peripheral nerves. Molecular Psychiatry 2010, 15: 234-236. PMID: 20168325, DOI: 10.1038/mp.2009.74.
- Desir G. Role of Novel Biomarkers in Chronic Kidney Disease: Renalase. 2010, 309-316. DOI: 10.1007/978-88-470-1463-3_24.
- Knauf F, Desir GV, Perazella MA. A Case of Extreme Hemodynamic Lability and Hypocalcemia. The American Journal Of The Medical Sciences 2009, 338: 241-244. PMID: 19590425, DOI: 10.1097/maj.0b013e3181a66af1.
- Desir GV. Regulation of blood pressure and cardiovascular function by renalase. Kidney International 2009, 76: 366-370. PMID: 19471322, DOI: 10.1038/ki.2009.169.
- Desir GV. Renalase deficiency in chronic kidney disease, and its contribution to hypertension and cardiovascular disease. Current Opinion In Nephrology & Hypertension 2008, 17: 181-185. PMID: 18277152, DOI: 10.1097/mnh.0b013e3282f521ba.
- Li G, Xu J, Wang P, Velazquez H, Li Y, Wu Y, Desir GV. Catecholamines Regulate the Activity, Secretion, and Synthesis of Renalase. Circulation 2008, 117: 1277-1282. PMID: 18299506, DOI: 10.1161/circulationaha.107.732032.
- Li Y, Wang P, Xu J, Gorelick F, Yamazaki H, Andrews N, Desir GV. Regulation of insulin secretion and GLUT4 trafficking by the calcium sensor synaptotagmin VII. Biochemical And Biophysical Research Communications 2007, 362: 658-664. PMID: 17720139, PMCID: PMC2194288, DOI: 10.1016/j.bbrc.2007.08.023.
- Xu J, Desir GV. Renalase, a new renal hormone: its role in health and disease. Current Opinion In Nephrology & Hypertension 2007, 16: 373-378. PMID: 17565281, DOI: 10.1097/mnh.0b013e3281bd8877.
- Desir GV. Renalase is a novel renal hormone that regulates cardiovascular function. International Journal Of Cardiology Cardiovascular Risk And Prevention 2007, 1: 99-103. PMID: 20409839, DOI: 10.1016/j.jash.2006.12.001.
- Li Y, Wang P, Xu J, Desir GV. Voltage-gated potassium channel Kv1.3 regulates GLUT4 trafficking to the plasma membrane via a Ca2+-dependent mechanism. American Journal Of Physiology - Cell Physiology 2006, 290: c345-c351. PMID: 16403947, DOI: 10.1152/ajpcell.00091.2005.
- J X, G L, P W, H V, X Y, Y L, Y W, A P, S C, GV D. Kidney and Blood Pressure—The Story Unfolds Renalase Is a Novel, Soluble Monoamine Oxidase That Regulates Cardiac Function and Blood Pressure. J Clin Invest. Journal Of The American Society Of Nephrology 2005, 16: 2521-2527. DOI: 10.1681/asn.2005070751.
- Desir GV. Kv1.3 potassium channel blockade as an approach to insulin resistance. Expert Opinion On Therapeutic Targets 2005, 9: 571-579. PMID: 15948674, DOI: 10.1517/14728222.9.3.571.
- Xu J, Li G, Wang P, Velazquez H, Yao X, Li Y, Wu Y, Peixoto A, Crowley S, Desir GV. Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. Journal Of Clinical Investigation 2005, 115: 1275-1280. PMID: 15841207, PMCID: PMC1074681, DOI: 10.1172/jci24066.
- Hebert SC, Desir G, Giebisch G, Wang W. Molecular Diversity and Regulation of Renal Potassium Channels. Physiological Reviews 2005, 85: 319-371. PMID: 15618483, PMCID: PMC2838721, DOI: 10.1152/physrev.00051.2003.
- Xu J, Wang P, Li Y, Li G, Kaczmarek LK, Wu Y, Koni PA, Flavell RA, Desir GV. The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 3112-3117. PMID: 14981264, PMCID: PMC365752, DOI: 10.1073/pnas.0308450100.
- Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS. International Union of Pharmacology. XLI. Compendium of Voltage-Gated Ion Channels: Potassium Channels. Pharmacological Reviews 2003, 55: 583-586. PMID: 14657415, DOI: 10.1124/pr.55.4.9.
- Xu J, Koni PA, Wang P, Li G, Kaczmarek L, Wu Y, Li Y, Flavell RA, Desir GV. The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight. Human Molecular Genetics 2003, 12: 551-559. PMID: 12588802, DOI: 10.1093/hmg/ddg049.
- Yao X, Tian S, Chan HY, Biemesderfer D, Desir GV. Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule. Journal Of The American Society Of Nephrology 2002, 13: 2831-9. PMID: 12444201, DOI: 10.1097/01.asn.0000036866.37886.c5.
- Segal AS, Hayslett JP, Desir GV. On the natriuretic effect of verapamil: inhibition of ENaC and transepithelial sodium transport. American Journal Of Physiology. Renal Physiology 2002, 283: f765-f770. PMID: 12217868, DOI: 10.1152/ajprenal.00253.2001.
- Tian S, Liu W, Wu Y, Rafi H, Segal AS, Desir GV. Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel β-subunit. American Journal Of Physiology. Renal Physiology 2002, 283: f142-f149. PMID: 12060596, DOI: 10.1152/ajprenal.00258.2001.
- Velázquez H, Silva T, Andújar E, Desir G, Ellison D, Greger R. The distal convoluted tubule of rabbit kidney does not express a functional sodium channel. American Journal Of Physiology. Renal Physiology 2001, 280: f530-f539. PMID: 11181416, DOI: 10.1152/ajprenal.2001.280.3.f530.
- Lang R, Lee G, Liu W, Tian S, Rafi H, Orias M, Segal A, Desir G. KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels. American Journal Of Physiology. Renal Physiology 2000, 278: f1013-f1021. PMID: 10836990, DOI: 10.1152/ajprenal.2000.278.6.f1013.
- Yao X, Liu W, Tian S, Rafi H, Segal A, Desir G. Close Association of the N Terminus of Kv1.3 with the Pore Region*. Journal Of Biological Chemistry 2000, 275: 10859-10863. PMID: 10753881, DOI: 10.1074/jbc.275.15.10859.
- Kunchaparty S, Palcso M, Berkman J, Velázquez H, Desir G, Bernstein P, Reilly R, Ellison D. Defective processing and expression of thiazide-sensitive Na-Cl cotransporter as a cause of Gitelman’s syndrome. American Journal Of Physiology 1999, 277: f643-f649. PMID: 10516289, DOI: 10.1152/ajprenal.1999.277.4.f643.
- Segal A, Yao X, Desir G. The T0 Domain of Rabbit KV1.3 Regulates Steady State Channel Protein Level. Biochemical And Biophysical Research Communications 1999, 254: 54-64. PMID: 9920732, DOI: 10.1006/bbrc.1998.9801.
- Yao X, Huang Y, Kwan H, Chan P, Desir G. Characterization of a Regulatory Region in the N-Terminus of Rabbit Kv1.3 Volume249,Number 2 (1998), pages 492–498:. Biochemical And Biophysical Research Communications 1998, 252: 284. DOI: 10.1006/bbrc.1998.9627.
- Velázquez H, Náray-Fejes-Tóth A, Silva T, Andújar E, Reilly RF, Desir GV, Ellison DH. Rabbit distal convoluted tubule coexpresses NaCl cotransporter and 11β-hydroxysteroid dehydrogenase II mRNA. Kidney International 1998, 54: 464-472. PMID: 9690213, DOI: 10.1046/j.1523-1755.1998.00036.x.
- Yao X, Huang Y, Kwan HY, Chan P, Segal AS, Desir G. Characterization of a Regulatory Region in the N-Terminus of Rabbit Kv1.3. Biochemical And Biophysical Research Communications 1998, 249: 492-498. PMID: 9712724, DOI: 10.1006/bbrc.1998.9122.
- Orias M, Velázquez H, Tung F, Lee G, Desir G. Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments. American Journal Of Physiology 1997, 273: f663-f666. PMID: 9362344, DOI: 10.1152/ajprenal.1997.273.4.f663.
- Orias M, Bray-Ward P, Curran M, Keating M, Desir G. Genomic Localization of the Human Gene for KCNA10, a cGMP-Activated K Channel. Genomics 1997, 42: 33-37. PMID: 9177773, DOI: 10.1006/geno.1997.4712.
- Yao X, Liu Y, Tung F, Desir GV. Genomic structure and regulation of Kcn1, a cGMP-gated potassium channel. American Journal Of Physiology 1996, 271: f37-f41. PMID: 8760241, DOI: 10.1152/ajprenal.1996.271.1.f37.
- Yao X, Chang AY, Boulpaep EL, Segal AS, Desir GV. Molecular cloning of a glibenclamide-sensitive, voltage-gated potassium channel expressed in rabbit kidney. Journal Of Clinical Investigation 1996, 97: 2525-2533. PMID: 8647945, PMCID: PMC507338, DOI: 10.1172/jci118700.
- Yao X, Segal AS, Welling P, Zhang X, McNicholas CM, Engel D, Boulpaep EL, Desir GV. Primary structure and functional expression of a cGMP-gated potassium channel. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 11711-11715. PMID: 8524834, PMCID: PMC40472, DOI: 10.1073/pnas.92.25.11711.
- Desir G. Molecular characterization of voltage and cyclic nucleotide-gated potassium channels in kidney. Kidney International 1995, 48: 1031-1035. PMID: 8569064, DOI: 10.1038/ki.1995.386.
- Desir G. The structure, regulation and pathophysiology of potassium channels. Current Opinion In Nephrology & Hypertension 1995, 4: 402-405. PMID: 8564442, DOI: 10.1097/00041552-199509000-00005.
- Desir G. Molecular Physiology of a Novel Cgmp-Gated Potassium Channel. 1995, 9: 237-245. DOI: 10.1007/978-94-011-0117-2_27.
- Desir GV, Velazquez H. Identification of a novel K-channel gene (KC22) that is highly expressed in distal tubule of rabbit kidney. American Journal Of Physiology 1993, 264: f128-f133. PMID: 7679255, DOI: 10.1152/ajprenal.1993.264.1.f128.
- Ellison DH, Biemesderfer D, Morrisey J, Lauring J, Desir GV. Immunocytochemical characterization of the high-affinity thiazide diuretic receptor in rabbit renal cortex. American Journal Of Physiology 1993, 264: f141-f148. PMID: 8430824, DOI: 10.1152/ajprenal.1993.264.1.f141.
- Desir G. Molecular physiology of renal potassium channels. Seminars In Nephrology 1992, 12: 531-40. PMID: 1475548.
- Inhibition of Ca-activated K+ channels from renal microvillus membrane vesicles by amiloride analogsZweifach A, Desir G, Aronson P, Giebisch G. Inhibition of Ca-activated K+ channels from renal microvillus membrane vesicles by amiloride analogs. The Journal Of Membrane Biology 1992, 128: 115-122. PMID: 1501239, DOI: 10.1007/bf00231884.
- Desir GV, Hamlin HA, Puente E, Reilly RF, Hildebrandt F, Igarashi P. Isolation of putative voltage-gated epithelial K-channel isoforms from rabbit kidney and LLC-PK1 cells. American Journal Of Physiology 1992, 262: f151-f157. PMID: 1733291, DOI: 10.1152/ajprenal.1992.262.1.f151.
- Ellison D, Morrisey J, Desir G. Solubilization and partial purification of the thiazide diuretic receptor from rabbit renal cortex. Biochimica Et Biophysica Acta 1991, 1069: 241-249. PMID: 1932064, DOI: 10.1016/0005-2736(91)90131-q.
- Reconstitution and partial purification of an amiloride-sensitive, cation channel from rabbit kidneyDesir G. Reconstitution and partial purification of an amiloride-sensitive, cation channel from rabbit kidney. Biochimica Et Biophysica Acta 1991, 1067: 38-42. PMID: 1868102, DOI: 10.1016/0005-2736(91)90023-2.
- Zweifach A, Desir GV, Aronson PS, Giebisch GH. A Ca-activated K channel from rabbit renal brush-border membrane vesicles in planar lipid bilayers. American Journal Of Physiology 1991, 261: f187-f196. PMID: 1713419, DOI: 10.1152/ajprenal.1991.261.1.f187.
- Desir GV, Cragoe EJ, Aronson PS. High affinity binding of amiloride analogs at an internal site in renal microvillus membrane vesicles. Journal Of Biological Chemistry 1991, 266: 2267-2271. PMID: 1846621, DOI: 10.1016/s0021-9258(18)52238-9.
- Desir G, Bia M, Lange R, Smith E, Flye W, Kashgarian M, Schiff M, Ezekowitz M. The Clinical Utility of Indium-111 Labeled Platelet Scintigraphy in the Diagnoses of Renal Transplant Rejection. 1990, 264-277. DOI: 10.1007/978-94-009-0581-8_24.
- Bia M, Desir G, Ezekowitz M, Lange R, Smith E, Kashgarian M, Schiff M. 568 Detection of Acute Allograft Rejection by Indium-111 Labeled Platelet Scintigraphy in Renal Transplant Patients. Journal Of Urology 1987, 137: 245a. DOI: 10.1016/s0022-5347(17)75718-7.
- Desir G, Bia MJ, Lange RC, Smith EO, Kashgarian M, Flye W, Schiff M, Ezekowitz MD. Detection of acute allograft rejection by indium-111 labeled platelet scintigraphy in renal transplant patients. Transplantation Proceedings 1987, 19: 1677-80. PMID: 3547876.
- Desir G, Bratusch-Marrain P, DeFronzo R. Effect of hyperketonemia on renal ammonia excretion in man. Metabolism 1986, 35: 736-743. PMID: 3736414, DOI: 10.1016/0026-0495(86)90241-6.
- Desir G, Helman D, Herlich M, Turka L, Bia M. Haemophilus parainfluenzae Liver Abscess in a Recipient of a Renal Transplant Who Had Polycystic Disease. JAMA 1986, 255: 1878-1878. PMID: 3512876, DOI: 10.1001/jama.1986.03370140076015.