- Yale Vascular SurgeryYale Physicians Building800 Howard Avenue, Fl 2New Haven, CT 06519
Bauer Sumpio, MD, PhD, FACS
Biography
Bauer Sumpio, MD, PhD, is a vascular surgeon who specializes in the care of patients with diseases of their arteries and veins. He engages in the limb salvage of people with diabetes who are at risk for losing their legs to their diabetic complications. He has decades of experience improving quality of life for patients with plaque build-up in major blood vessels which hinder flow to the critical organs, such as the kidneys, intestine (mesenteric ischemia), legs (claudication and critical limb ischemia) and brain (carotid artery disease).
According to Dr. Sumpio, vascular surgery has become a much less invasive procedure in recent years. He gives credit to the development of endovascular therapeutic techniques, which allow doctors to treat problems from inside the affected blood vessel. Surgeons are able to operate through small punctures of an artery, using tiny, flexible tubes, called catheters, to access the blood vessels. “This means we can fix things from the inside without having to open up the abdomen, chest or neck,” Dr. Sumpio says. These techniques are useful not only in opening up blockages in the artery with a balloon or stent but also for repair of abnormal weakening of the walls of the artery (aneurysm). “Most important for the patient is to have a surgeon who is not only skilled in these endovascular interventions but is capable of performing open surgical procedures when it is appropriate and indicated.”
Other conditions that Dr. Sumpio is skilled in treating include varicose veins using minimal invasive procedures such as laser or radio-frequency to remove dysfunctional veins or varicose veins.
Over his many years of caring for patients, Dr. Sumpio says he has come to understand that “the most important quality a physician can have is compassion. Once a patient trusts you, they understand you will make the best decision in their interest.”
As a professor of vascular surgery at Yale School of Medicine, Dr. Sumpio has also performed basic research on blood flow and how it can affect the vascular wall.
Titles
- Professor of Surgery (Vascular) and of Radiology and Biomedical Imaging and of Medicine (Cardiology)
- Associate Director, Graduate Medical Education
Education & Training
- FellowUniversity of North Carolina, North Carolina Memorial Hospital, Chapel Hill, NC (1987)
- ResidentYale-New Haven Hospital, New Haven, CT (1986)
- PhDCornell University (1981)
- MDCornell University (1980)
Languages Spoken
- English
- Wikang Filipino (Filipino)
Additional Information
- Kim TI, Mena C, Sumpio BE. The Role of Lower Extremity Amputation in Chronic Limb-Threatening Ischemia. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2020, 29: 149-155. PMID: 32904807, PMCID: PMC7458760, DOI: 10.1055/s-0040-1710075.
- Rajaee S, Holder T, Indes JE, Muhs B, Sarac T, Sumpio B, Toll BA, Ochoa Chaar CI. A Pilot Study of a Standardized Smoking Cessation Intervention for Patients with Vascular Disease. Annals Of Vascular Surgery 2019, 61: 91-99.e3. PMID: 31449932, DOI: 10.1016/j.avsg.2019.06.017.
- Brahmandam A, Skrip L, Mojibian H, Aruny J, Sumpio B, Dardik A, Sarac T, Ochoa Chaar CI. Costs and complications of endovascular inferior vena cava filter retrieval. Journal Of Vascular Surgery. Venous And Lymphatic Disorders 2019, 7: 653-659.e1. PMID: 31307952, DOI: 10.1016/j.jvsv.2019.02.017.
- Aurshina A, Zhang Y, Zhuo H, Cardella J, Orion K, Sumpio B, Sarac T, Ochoa Chaar CI. Safety and efficacy of venous ablation in octogenarians. Journal Of Vascular Surgery. Venous And Lymphatic Disorders 2019, 7: 685-692. PMID: 31421837, DOI: 10.1016/j.jvsv.2019.05.006.
- Miller SM, Sumpio BJ, Miller MS, Erben Y, Cordova AC, Sumpio BE. Higher Inpatient Mortality for Women after Intervention for Lifestyle Limiting Claudication. Annals Of Vascular Surgery 2019, 58: 54-62. PMID: 30910650, DOI: 10.1016/j.avsg.2019.01.006.
- Brahmandam A, Skrip L, Sumpio B, Indes J, Dardik A, Sarac T, Rectenwald J, Chaar CIO. A survey of vascular specialists' practice patterns of inferior vena cava filter placement and retrieval. Vascular 2019, 27: 291-298. PMID: 30501583, DOI: 10.1177/1708538118815394.
- Kim TI, Sumpio BE. Management of Asymptomatic Popliteal Artery Aneurysms. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2019, 28: 5-10. PMID: 30880884, PMCID: PMC6417913, DOI: 10.1055/s-0038-1676792.
- Wu RT, Sumpio BJ, Miller S, Sumpio BE. Use of Closed-Incision Negative-Pressure Therapy: Cardiothoracic and Vascular Surgery. Plastic And Reconstructive Surgery 2019, 143: 31S-35S. PMID: 30586101, DOI: 10.1097/PRS.0000000000005310.
- Chitragari G, Shalaby SY, Sumpio BJ, Kurita J, Sumpio BE. Regulation of Yes-Associated Protein by Laminar Flow. Annals Of Vascular Surgery 2018, 52: 183-191. PMID: 29758328, DOI: 10.1016/j.avsg.2018.03.002.
- Aurshina A, Zhang Y, Wang F, Cardella J, Orion K, Sumpio B, Sarac T, Ochoa Chaar CI. The effect of increasing catheter distance from the deep junction on the outcomes of radiofrequency vein ablation. Journal Of Vascular Surgery. Venous And Lymphatic Disorders 2018, 6: 614-620. PMID: 29784594, DOI: 10.1016/j.jvsv.2018.04.006.
- Erben Y, Protack CD, Jean RA, Sumpio BJ, Miller SM, Liu S, Trejo G, Sumpio BE. Endovascular interventions decrease length of hospitalization and are cost-effective in acute mesenteric ischemia. Journal Of Vascular Surgery 2018, 68: 459-469. PMID: 29459015, DOI: 10.1016/j.jvs.2017.11.078.
- Erben Y, Miller SM, Sumpio BJ, Dillon BJ, Lee AI, Blume P, Sumpio BE, Mena-Hurtado C. Acute Limb Ischemia in an 8-Year-Old Patient: A Case Report. Annals Of Vascular Surgery 2018, 51: 327.e1-327.e8. PMID: 29655809, DOI: 10.1016/j.avsg.2018.02.012.
- Erben Y, Jean RA, Protack CD, Chiu AS, Liu S, Sumpio BJ, Miller SM, Sumpio BE. Improved mortality in treatment of patients with endovascular interventions for chronic mesenteric ischemia. Journal Of Vascular Surgery 2018, 67: 1805-1812. PMID: 29395425, DOI: 10.1016/j.jvs.2017.10.071.
- Erben Y, Mena-Hurtado CI, Miller SM, Jean RA, Sumpio BJ, Velasquez CA, Mojibian H, Aruny J, Dardik A, Sumpio BE. Increased mortality in octogenarians treated for lifestyle limiting claudication. Catheterization And Cardiovascular Interventions : Official Journal Of The Society For Cardiac Angiography & Interventions 2018, 91: 1331-1338. PMID: 29405592, DOI: 10.1002/ccd.27523.
- Ochoa Chaar CI, Aurshina A, Zhang Y, Wang F, Cardella J, Orion K, Sumpio B, Sarac T. The effect of commercial insurance policies on outcomes of venous ablation. Journal Of Vascular Surgery. Venous And Lymphatic Disorders 2018, 6: 331-337.e1. PMID: 29661363, DOI: 10.1016/j.jvsv.2017.11.013.
- Alvelo JL, Papademetris X, Mena-Hurtado C, Jeon S, Sumpio BE, Sinusas AJ, Stacy MR. Radiotracer Imaging Allows for Noninvasive Detection and Quantification of Abnormalities in Angiosome Foot Perfusion in Diabetic Patients With Critical Limb Ischemia and Nonhealing Wounds. Circulation. Cardiovascular Imaging 2018, 11: e006932. PMID: 29748311, PMCID: PMC5951395, DOI: 10.1161/CIRCIMAGING.117.006932.
- Henry HT, Szolomayer LK, Sumpio BE, Sutton KM. Popliteal Artery Entrapment Syndrome: Bilateral Lower Extremity Involvement. Orthopedics 2018, 41: e295-e298. PMID: 28934539, DOI: 10.3928/01477447-20170918-10.
- Protack C, Wengerter B, Jean RA, Liu S, Mojibian H, Sumpio B, Dardik A, Maung AA, Erben Y. Overutilization of Cross-Sectional Imaging in the Lower Extremity Trauma Setting. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2018, 27: 23-28. PMID: 29483762, PMCID: PMC5825222, DOI: 10.1055/s-0037-1612622.
- Gupta S, Andersen C, Black J, de Leon J, Fife C, Lantis Ii JC, Niezgoda J, Snyder R, Sumpio B, Tettelbach W, Treadwell T, Weir D, Silverman RP. Management of Chronic Wounds: Diagnosis, Preparation, Treatment, and Follow-up. Wounds : A Compendium Of Clinical Research And Practice 2017, 29: S19-S36. PMID: 28862980.
- Ochoa Chaar CI, Shebl F, Sumpio B, Dardik A, Indes J, Sarac T. Distal embolization during lower extremity endovascular interventions. Journal Of Vascular Surgery 2017, 66: 143-150. PMID: 28366300, DOI: 10.1016/j.jvs.2017.01.032.
- Shalaby SY, Chitragari G, Sumpio BJ, Sumpio BE. Shear Stress Induces Change in Extracellular Signal-Regulated Kinase 5 Levels with Sustained Activation under Disturbed and Continuous Laminar Flow. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2017, 26: 109-115. PMID: 28566937, PMCID: PMC5446257, DOI: 10.1055/s-0037-1599057.
- Haser GC, Sumpio B. Systemic and cell-specific mechanisms of vasculopathy induced by human immunodeficiency virus and highly active antiretroviral therapy. Journal Of Vascular Surgery 2017, 65: 849-859. PMID: 26994951, DOI: 10.1016/j.jvs.2016.01.036.
- Chin JA, Skrip L, Sumpio BE, Cardella JA, Indes JE, Sarac TP, Dardik A, Ochoa Chaar CI. Percutaneous endovascular aneurysm repair in morbidly obese patients. Journal Of Vascular Surgery 2017, 65: 643-650.e1. PMID: 28034584, DOI: 10.1016/j.jvs.2016.06.115.
- Gates L, Chin JA, Bonde PN, Ochoa Chaar CI, Sumpio BE, Sarac TP. Explantation of infected aortic aneurysm and endograft with ascending aorta to mesenteric bypass for mesenteric ischemia. Journal Of Vascular Surgery 2017, 65: 219-223. PMID: 27183855, DOI: 10.1016/j.jvs.2016.03.411.
- Sumpio BJ, Citoni G, Chin JA, Sumpio BE. Use of hyperspectral imaging to assess endothelial dysfunction in peripheral arterial disease. Journal Of Vascular Surgery 2016, 64: 1066-73. PMID: 27266597, DOI: 10.1016/j.jvs.2016.03.463.
- Hogendoorn W, Moll FL, Sumpio BE, Hunink MG. Clinical Decision Analysis and Markov Modeling for Surgeons: An Introductory Overview. Annals Of Surgery 2016, 264: 268-74. PMID: 26756750, DOI: 10.1097/SLA.0000000000001569.
- Huynh N, Gates L, Scoutt L, Sumpio B, Sarac T, Ochoa Chaar CI. May-Thurner syndrome and iliac arteriovenous fistula in an elderly woman. Journal Of Vascular Surgery Cases And Innovative Techniques 2016, 2: 46-49. PMID: 31193380, PMCID: PMC6526307, DOI: 10.1016/j.jvsc.2016.02.001.
- Rajaee S, Hurtado CM, Sumpio B. Drug-Eluting Stents: New Tools for the Armamentarium Against Peripheral Arterial Disease. Surgical Technology International 2015, 27: 200-7. PMID: 26680398.
- Chitragari G, Schlosser FJ, Ochoa Chaar CI, Sumpio BE. Consequences of hypogastric artery ligation, embolization, or coverage. Journal Of Vascular Surgery 2015, 62: 1340-7.e1. PMID: 26386508, DOI: 10.1016/j.jvs.2015.08.053.
- Hogendoorn W, Lavida A, Hunink MG, Moll FL, Geroulakos G, Muhs BE, Sumpio BE. Cost-effectiveness of endovascular repair, open repair, and conservative management of splenic artery aneurysms. Journal Of Vascular Surgery 2015, 61: 1432-40. PMID: 25827968, DOI: 10.1016/j.jvs.2014.12.064.
- Sherif S, Sumpio BE. Economic development and diabetes prevalence in MENA countries: Egypt and Saudi Arabia comparison. World Journal Of Diabetes 2015, 6: 304-11. PMID: 25789111, PMCID: PMC4360423, DOI: 10.4239/wjd.v6.i2.304.
- Sumpio BJ, Chitragari G, Moriguchi T, Shalaby S, Pappas-Brown V, Khan AM, Sekaran SD, Sumpio BE, Grab DJ. African Trypanosome-Induced Blood-Brain Barrier Dysfunction under Shear Stress May Not Require ERK Activation. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2015, 24: 41-6. PMID: 27053915, PMCID: PMC4813428, DOI: 10.1055/s-0034-1370890.
- Moriguchi T, Sumpio BE. PECAM-1 phosphorylation and tissue factor expression in HUVECs exposed to uniform and disturbed pulsatile flow and chemical stimuli. Journal Of Vascular Surgery 2015, 61: 481-8. PMID: 24342062, DOI: 10.1016/j.jvs.2013.09.059.
- Young CJ, Dardik A, Sumpio B, Indes J, Muhs B, Ochoa Chaar CI. Venous ulcer: late complication of a traumatic arteriovenous fistula. Annals Of Vascular Surgery 2015, 29: 836.e1-3. PMID: 25725283, DOI: 10.1016/j.avsg.2014.11.020.
- Schulte W, Rodriguez-Davalos M, Lujic M, Schlosser F, Sumpio B. Operative Management of Hilar Renal Artery Aneurysm in a Pregnant Patient. Annals Of Vascular Diseases 2015, 8: 242-5. PMID: 26421074, PMCID: PMC4575337, DOI: 10.3400/avd.cr.15-00026.
- Hogendoorn W, Lavida A, Hunink MG, Moll FL, Geroulakos G, Muhs BE, Sumpio BE. Open repair, endovascular repair, and conservative management of true splenic artery aneurysms. Journal Of Vascular Surgery 2014, 60: 1667-76.e1. PMID: 25264364, DOI: 10.1016/j.jvs.2014.08.067.
- Chin JA, Sumpio BE. New advances in limb salvage. Surgical Technology International 2014, 25: 212-6. PMID: 25433346.
- Chitragari G, Shalaby SY, Sumpio BJ, Sumpio BE. Effect of pulsatile and continuous flow on yes-associated protein. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2014, 23: 183-6. PMID: 25317030, PMCID: PMC4169103, DOI: 10.1055/s-0034-1376865.
- Shalaby S, Chitragari G, Sumpio BJ, Sumpio BE. Characterization of extracellular signal-regulated kinase 5 levels in human umbilical vein endothelial cells exposed to disturbed and uniform flow. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2014, 23: 187-92. PMID: 25317031, PMCID: PMC4169104, DOI: 10.1055/s-0034-1378136.
- Hogendoorn W, Hunink MG, Schlösser FJ, Moll FL, Muhs BE, Sumpio BE. A comparison of open and endovascular revascularization for chronic mesenteric ischemia in a clinical decision model. Journal Of Vascular Surgery 2014, 60: 715-25.e2. PMID: 24721175, DOI: 10.1016/j.jvs.2014.03.009.
- Hogendoorn W, Hunink MG, Schlösser FJ, Moll FL, Sumpio BE, Muhs BE. Endovascular vs. open repair of complicated acute type B aortic dissections. Journal Of Endovascular Therapy : An Official Journal Of The International Society Of Endovascular Specialists 2014, 21: 503-14. PMID: 25101577, DOI: 10.1583/14-4716R.1.
- Hogendoorn W, Hunink MG, Schlösser FJ, Moll FL, Sumpio BE, Muhs BE. A clinical decision model for selecting the most appropriate therapy for uncomplicated chronic dissections of the descending aorta. Journal Of Vascular Surgery 2014, 60: 20-30. PMID: 24613191, DOI: 10.1016/j.jvs.2014.01.054.
- Ziegler KR, Cruz J, Muhs BE, Indes JE, Sumpio BE, Chaar CI. Iatrogenic profunda femoris stenosis after superficial femoral artery stenting. The American Surgeon 2014, 80: E155-6. PMID: 24887776.
- Hogendoorn W, Schlösser FJ, Aruny JE, Indes JE, Sumpio BE, Muhs BE. Successful treatment of a proximal type I endoleak with HeliFX EndoAnchors. Annals Of Vascular Surgery 2014, 28: 737.e13-7. PMID: 24184495, DOI: 10.1016/j.avsg.2013.07.028.
- Hogendoorn W, Schlösser FJ, Moll FL, Muhs BE, Hunink MG, Sumpio BE. Decision analysis model of open repair versus endovascular treatment in patients with asymptomatic popliteal artery aneurysms. Journal Of Vascular Surgery 2014, 59: 651-62. PMID: 24246533, DOI: 10.1016/j.jvs.2013.09.026.
- Benitez E, Sumpio BJ, Chin J, Sumpio BE. Contemporary assessment of foot perfusion in patients with critical limb ischemia. Seminars In Vascular Surgery 2014, 27: 3-15. PMID: 25812754, DOI: 10.1053/j.semvascsurg.2014.12.001.
- Chitragari G, Mahler DB, Sumpio BJ, Blume PA, Sumpio BE. Prosthetic options available for the diabetic lower limb amputee. Clinics In Podiatric Medicine And Surgery 2014, 31: 173-85. PMID: 24296024, DOI: 10.1016/j.cpm.2013.09.008.
- Blume PA, Sumpio B, Schmidt B, Donegan R. Charcot neuroarthropathy of the foot and ankle: diagnosis and management strategies. Clinics In Podiatric Medicine And Surgery 2014, 31: 151-72. PMID: 24296023, DOI: 10.1016/j.cpm.2013.09.007.
- Shalaby SY, Blume P, Sumpio BE. New modalities in the chronic ischemic diabetic foot management. Clinics In Podiatric Medicine And Surgery 2014, 31: 27-42. PMID: 24296016, DOI: 10.1016/j.cpm.2013.09.009.
- Chin JA, Sumpio BE. Diabetes mellitus and peripheral vascular disease: diagnosis and management. Clinics In Podiatric Medicine And Surgery 2014, 31: 11-26. PMID: 24296015, DOI: 10.1016/j.cpm.2013.09.001.
- Donegan R, Sumpio B, Blume PA. Charcot foot and ankle with osteomyelitis. Diabetic Foot & Ankle 2013, 4 PMID: 24098835, PMCID: PMC3789286, DOI: 10.3402/dfa.v4i0.21361.
- Brölmann FE, Eskes AM, Sumpio BE, Mayer DO, Moore Z, Agren MS, Hermans M, Cutting K, Legemate DA, Vermeulen H, Ubbink DT. Fundamentals of randomized clinical trials in wound care: reporting standards. Wound Repair And Regeneration : Official Publication Of The Wound Healing Society [and] The European Tissue Repair Society 2013, 21: 641-7. PMID: 23937172, DOI: 10.1111/wrr.12087.
- Sumpio BE, Forsythe RO, Ziegler KR, van Baal JG, Lepantalo MJ, Hinchliffe RJ. Clinical implications of the angiosome model in peripheral vascular disease. Journal Of Vascular Surgery 2013, 58: 814-26. PMID: 23972249, DOI: 10.1016/j.jvs.2013.06.056.
- Hogendoorn W, Schlösser FJ, Moll FL, Sumpio BE, Muhs BE. Thoracic endovascular aortic repair with the chimney graft technique. Journal Of Vascular Surgery 2013, 58: 502-11. PMID: 23697513, DOI: 10.1016/j.jvs.2013.03.043.
- Sumpio B, Shine SR, Mahler D, Sumpio BE. A comparison of immediate postoperative rigid and soft dressings for below-knee amputations. Annals Of Vascular Surgery 2013, 27: 774-80. PMID: 23880455, DOI: 10.1016/j.avsg.2013.03.007.
- Sumpio BE. Application of Porter’s Five Forces Model and generic strategies for vascular surgery: should be stuck in the middle? Vascular 2013, 21: 149-56. PMID: 23518839, DOI: 10.1177/1708538112473707.
- Hogendoorn W, Schlösser FJ, Sumpio BE. A Giant Superior Mesenteric Artery Aneurysm Mimicking an Abdominal Aortic Aneurysm. Aorta (Stamford, Conn.) 2013, 1: 52-6. PMID: 26798672, PMCID: PMC4682698, DOI: 10.12945/j.aorta.2013.12.010.
- Fonseca AL, Cleary MA, Cholewczynski W, Sumpio BE, Atweh NA. Omental vein catheter thrombolysis for acute porto-mesenteric vein thrombosis. Annals Of Vascular Surgery 2013, 27: 497.e1-4. PMID: 23566871, DOI: 10.1016/j.avsg.2012.09.009.
- Sumpio BE. Too small to fail: the prisoner's dilemma. Journal Of Vascular Surgery 2013, 57: 1415-21. PMID: 23601596, DOI: 10.1016/j.jvs.2013.01.005.
- Brown HA, Aruny JE, Elefteriades JA, Sumpio BE. Subclavian aneurysm presenting with massive hemoptysis: a case report and review of the literature. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2013, 22: 69-74. PMID: 24436588, PMCID: PMC3699228, DOI: 10.1055/s-0033-1333862.
- Davis B, Moriguchi T, Sumpio B. Optimizing cardiovascular benefits of exercise: a review of rodent models. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2013, 22: 13-22. PMID: 24436579, PMCID: PMC3699221, DOI: 10.1055/s-0033-1333867.
- Cordova AC, Sumpio BE. [Not Available]. Annals Of Vascular Diseases 2013, 6: 687-93. PMID: 24386016, PMCID: PMC3866356, DOI: 10.3400/avd.ra.13-00045.
- Eskes AM, Brölmann FE, Sumpio BE, Mayer D, Moore Z, Agren MS, Hermans M, Cutting K, Legemate DA, Ubbink DT, Vermeulen H. Fundamentals of randomized clinical trials in wound care: design and conduct. Wound Repair And Regeneration : Official Publication Of The Wound Healing Society [and] The European Tissue Repair Society 2012, 20: 449-55. PMID: 22642397, DOI: 10.1111/j.1524-475X.2012.00799.x.
- Abe R, Beckett J, Abe R, Nixon A, Rochier A, Yamashita N, Sumpio B. Olive Oil Polyphenols Differentially Inhibit Smooth Muscle Cell Proliferation through a G1/S Cell Cycle Block Regulated by ERK1/2. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2012, 21: 69-76. PMID: 23730132, PMCID: PMC3444010, DOI: 10.1055/s-0032-1315630.
- Basco MT, Schlösser FJ, Muhs BE, Indes JE, Blume PA, Key JJ, Aruny JE, Sumpio BE. Lower extremity limb salvage with cryoplasty: a single-center cohort study. Vascular 2012, 20: 36-41. PMID: 22328618, DOI: 10.1258/vasc.2011.oa0309.
- Sumpio BE. Contemporary evaluation and management of the diabetic foot. Scientifica 2012, 2012: 435487. PMID: 24278695, PMCID: PMC3820495, DOI: 10.6064/2012/435487.
- Cordova AC, Sumpio BJ, Sumpio BE. Perfecting the plate: adding cardioprotective compounds to the diet. Journal Of The American College Of Surgeons 2012, 214: 97-114. PMID: 22055584, DOI: 10.1016/j.jamcollsurg.2011.09.023.
- Ikem I, Sumpio BE. Cardiovascular disease: the new epidemic in sub-Saharan Africa. Vascular 2011, 19: 301-7. PMID: 21940758, DOI: 10.1258/vasc.2011.ra0049.
- Sumpio B, Thakor P, Mahler D, Blume P. Negative pressure wound therapy as postoperative dressing in below knee amputation stump closure of patients with chronic venous insufficiency. Wounds : A Compendium Of Clinical Research And Practice 2011, 23: 301-8. PMID: 25881107.
- Yamashita N, Abe R, Nixon AM, Rochier AL, Madri JA, Sumpio BE. Cyclic strain delays the expression of tissue factor induced by thrombin in human umbilical vein endothelial cells. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2011, 20: 157-66. PMID: 22942631, PMCID: PMC3331651, DOI: 10.1055/s-0031-1284475.
- Abe R, Yamashita N, Rochier A, Nixon A, Abe R, Madri JA, Sumpio BE. Varying effects of hemodynamic forces on tissue factor RNA expression in human endothelial cells. The Journal Of Surgical Research 2011, 170: 150-6. PMID: 21592524, DOI: 10.1016/j.jss.2011.04.002.
- Rochier A, Nixon A, Yamashita N, Abe R, Abe R, Madri JA, Sumpio BE. Laminar shear, but not orbital shear, has a synergistic effect with thrombin stimulation on tissue factor expression in human umbilical vein endothelial cells. Journal Of Vascular Surgery 2011, 54: 480-8. PMID: 21367569, DOI: 10.1016/j.jvs.2011.01.002.
- Esemuede N, Lee T, Maier KG, Sumpio BE, Gahtan V. Lovastatin inhibits thrombospondin-1-induced smooth muscle cell chemotaxis. The Journal Of Surgical Research 2011, 168: 149-54. PMID: 20338582, DOI: 10.1016/j.jss.2009.11.728.
- Schlösser FJ, Aruny JE, Freiburg CB, Mojibian HR, Sumpio BE, Muhs BE. The chimney procedure is an emergently available endovascular solution for visceral aortic aneurysm rupture. Journal Of Vascular Surgery 2011, 53: 1386-90. PMID: 21276684, DOI: 10.1016/j.jvs.2010.11.097.
- Abe R, Yamashita N, Rochier A, Abe R, Nixon A, Madri JA, Sumpio BE. Pulsatile to-fro flow induces greater and sustained expression of tissue factor RNA in HUVEC than unidirectional laminar flow. American Journal Of Physiology. Heart And Circulatory Physiology 2011, 300: H1345-51. PMID: 21257914, PMCID: PMC3075035, DOI: 10.1152/ajpheart.01197.2010.
- Feng Y, Schlösser FJ, Sumpio BE. The Semmes Weinstein monofilament examination is a significant predictor of the risk of foot ulceration and amputation in patients with diabetes mellitus. Journal Of Vascular Surgery 2011, 53: 220-226.e1-5. PMID: 20692793, DOI: 10.1016/j.jvs.2010.06.100.
- Cordova AC, Bowen FW, Price LA, Dudrick SJ, Sumpio BE. Traumatic innominate artery pseudoaneurysm in the setting of a bovine arch. Annals Of Vascular Diseases 2011, 4: 252-5. PMID: 23555463, PMCID: PMC3595805, DOI: 10.3400/avd.cr.11.00028.
- Willis AI, Sadowitz B, Fuse S, Maier KG, Lee TS, Wang XJ, Tuszynski GP, Sumpio BE, Gahtan V. Thrombospondin 1, fibronectin, and vitronectin are differentially dependent upon RAS, ERK1/2, and p38 for induction of vascular smooth muscle cell chemotaxis. Vascular And Endovascular Surgery 2011, 45: 55-62. PMID: 21193465, DOI: 10.1177/1538574410387677.
- Blume PA, Key JJ, Thakor P, Thakor S, Sumpio B. Retrospective evaluation of clinical outcomes in subjects with split-thickness skin graft: comparing V.A.C.® therapy and conventional therapy in foot and ankle reconstructive surgeries. International Wound Journal 2010, 7: 480-7. PMID: 20825510, PMCID: PMC7951281, DOI: 10.1111/j.1742-481X.2010.00728.x.
- Jonker FH, Schlosser FJ, Geirsson A, Sumpio BE, Moll FL, Muhs BE. Endograft collapse after thoracic endovascular aortic repair. Journal Of Endovascular Therapy : An Official Journal Of The International Society Of Endovascular Specialists 2010, 17: 725-34. PMID: 21142480, DOI: 10.1583/10-3130.1.
- Liapis C, Veith F, Riambau V, Sumpio B, Azuma N, Lee TS, Parakh R, Biasi G. Terms of reference for the Standards of Practice and Training Committee. Vascular 2010, 18: 227-9. PMID: 20643032, DOI: 10.2310/6670.2009.00051.
- Sumpio BE, Armstrong DG, Lavery LA, Andros G. The role of interdisciplinary team approach in the management of the diabetic foot: a joint statement from the Society for Vascular Surgery and the American Podiatric Medical Association. Journal Of The American Podiatric Medical Association 2010, 100: 309-11. PMID: 20660885, DOI: 10.7547/1000309.
- Nixon AM, Gunel M, Sumpio BE. The critical role of hemodynamics in the development of cerebral vascular disease. Journal Of Neurosurgery 2010, 112: 1240-53. PMID: 19943737, DOI: 10.3171/2009.10.JNS09759.
- Basco MT, Yiu WK, Cheng SW, Sumpio BE. The effects of freezing versus supercooling on vascular cells: implications for balloon cryoplasty. Journal Of Vascular And Interventional Radiology : JVIR 2010, 21: 910-5. PMID: 20417120, PMCID: PMC2878641, DOI: 10.1016/j.jvir.2010.02.016.
- Sumpio BE, Armstrong DG, Lavery LA, Andros G. The role of interdisciplinary team approach in the management of the diabetic foot: a joint statement from the Society for Vascular Surgery and the American Podiatric Medical Association. Journal Of Vascular Surgery 2010, 51: 1504-6. PMID: 20488327, DOI: 10.1016/j.jvs.2010.04.010.
- Jonker FH, Schlosser FJ, Indes JE, Sumpio BE, Botta DM, Moll FL, Muhs BE. Management of type A aortic dissections: a meta-analysis of the literature. The Annals Of Thoracic Surgery 2010, 89: 2061-6. PMID: 20494094, DOI: 10.1016/j.athoracsur.2009.11.020.
- Jonker FH, Trimarchi S, Verhagen HJ, Moll FL, Sumpio BE, Muhs BE. Meta-analysis of open versus endovascular repair for ruptured descending thoracic aortic aneurysm. Journal Of Vascular Surgery 2010, 51: 1026-32, 1032.e1-1032.e2. PMID: 20347700, DOI: 10.1016/j.jvs.2009.10.103.
- Tan A, Sumpio BE, Lee S, Seifalian AM. The implications of human stem cell differentiation to endothelial cell via fluid shear stress in cardiovascular regenerative medicine: a review. Current Pharmaceutical Design 2010, 16: 3848-61. PMID: 21128890, DOI: 10.2174/138161210794455058.
- Duffy AJ, Panait L, Eisenberg D, Bell RL, Roberts KE, Sumpio B. Management of median arcuate ligament syndrome: a new paradigm. Annals Of Vascular Surgery 2009, 23: 778-84. PMID: 19128929, DOI: 10.1016/j.avsg.2008.11.005.
- Cordova AC, Sumpio BE. Polyphenols are medicine: Is it time to prescribe red wine for our patients? The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2009, 18: 111-7. PMID: 22477510, PMCID: PMC2903024, DOI: 10.1055/s-0031-1278336.
- Feng Y, Schlösser FJ, Sumpio BE. The Semmes Weinstein monofilament examination as a screening tool for diabetic peripheral neuropathy. Journal Of Vascular Surgery 2009, 50: 675-82, 682.e1. PMID: 19595541, DOI: 10.1016/j.jvs.2009.05.017.
- Rochier AL, Sumpio BE. Variant of popliteal entrapment syndrome involving the lateral head of the gastrocnemius muscle: a case report. Annals Of Vascular Surgery 2009, 23: 535.e5-9. PMID: 19467831, DOI: 10.1016/j.avsg.2009.02.003.
- Nishimura K, Blume P, Ohgi S, Sumpio BE. The effect of different frequencies of stretch on human dermal keratinocyte proliferation and survival. The Journal Of Surgical Research 2009, 155: 125-31. PMID: 19059608, DOI: 10.1016/j.jss.2008.07.029.
- Orgill DP, Manders EK, Sumpio BE, Lee RC, Attinger CE, Gurtner GC, Ehrlich HP. The mechanisms of action of vacuum assisted closure: more to learn. Surgery 2009, 146: 40-51. PMID: 19541009, DOI: 10.1016/j.surg.2009.02.002.
- Wen H, Blume PA, Sumpio BE. Role of integrins and focal adhesion kinase in the orientation of dermal fibroblasts exposed to cyclic strain. International Wound Journal 2009, 6: 149-58. PMID: 19432665, PMCID: PMC7951581, DOI: 10.1111/j.1742-481X.2009.00591.x.
- Longo WE, Sumpio B, Duffy A, Seashore J, Udelsman R. Early specialization in surgery: the new frontier. The Yale Journal Of Biology And Medicine 2008, 81: 187-91. PMID: 19099049, PMCID: PMC2605312.
- Huang CL, Sumpio BE. Olive oil, the mediterranean diet, and cardiovascular health. Journal Of The American College Of Surgeons 2008, 207: 407-16. PMID: 18722947, DOI: 10.1016/j.jamcollsurg.2008.02.018.
- Sumpio BE, Allie DE, Horvath KA, Marston WA, Meites HL, Mills JL, Orgill DP, Salazar JD, Song DH, Toursarkissian B. Role of negative pressure wound therapy in treating peripheral vascular graft infections. Vascular 2008, 16: 194-200. PMID: 18845099, DOI: 10.2310/6670.2008.00041.
- Fuse S, Esemuede N, Yamaguchi M, Maier KG, Nesselroth SM, Sumpio BE, Gahtan V. The role of G proteins in thromospondin-1-induced vascular smooth muscle cell migration. Surgery 2008, 144: 86-92. PMID: 18571589, DOI: 10.1016/j.surg.2008.03.028.
- Bazan HA, Pradhan S, Westvik TS, Sumpio BE, Gusberg RJ, Dardik A. Urgent carotid endarterectomy is safe in patients with few comorbid medical conditions. Annals Of Vascular Surgery 2008, 22: 505-12. PMID: 18462920, DOI: 10.1016/j.avsg.2007.12.019.
- Wang XJ, Maier K, Fuse S, Willis AI, Olson E, Nesselroth S, Sumpio BE, Gahtan V. Thrombospondin-1-induced migration is functionally dependent upon focal adhesion kinase. Vascular And Endovascular Surgery 2008, 42: 256-62. PMID: 18319354, DOI: 10.1177/1538574408314440.
- Yiu WK, Cheng SW, Sumpio BE. Synergistic effect of cool/thaw cycles on vascular cells in an in vitro model of cryoplasty. Journal Of Vascular And Interventional Radiology : JVIR 2008, 19: 925-30. PMID: 18503909, DOI: 10.1016/j.jvir.2008.02.007.
- Spate K, Aziz F, Sumpio BE. The use of retrievable inferior vena cava filters in the trauma population. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2008, 17: 23-6. PMID: 22477367, PMCID: PMC2728370, DOI: 10.1055/s-0031-1278275.
- Tang PC, Ravji K, Key JJ, Mahler DB, Blume PA, Sumpio B. Let them walk! Current prosthesis options for leg and foot amputees. Journal Of The American College Of Surgeons 2008, 206: 548-60. PMID: 18308228, DOI: 10.1016/j.jamcollsurg.2007.10.007.
- Kim JI, Cordova AC, Hirayama Y, Madri JA, Sumpio BE. Differential effects of shear stress and cyclic strain on Sp1 phosphorylation by protein kinase Czeta modulates membrane type 1-matrix metalloproteinase in endothelial cells. Endothelium : Journal Of Endothelial Cell Research 2008, 15: 33-42. PMID: 18568943, PMCID: PMC2644408, DOI: 10.1080/10623320802092260.
- Bazan HA, Reiner E, Sumpio B. Management of bilateral phlegmasia cerulea dolens in a patient with subacute splenic laceration. Annals Of Vascular Diseases 2008, 1: 45-8. PMID: 23555338, PMCID: PMC3610218, DOI: 10.3400/avd.AVDcr07002.
- Hirayama Y, Sumpio BE. Role of ligand-specific integrins in endothelial cell alignment and elongation induced by cyclic strain. Endothelium : Journal Of Endothelial Cell Research 2007, 14: 275-83. PMID: 18080865, DOI: 10.1080/10623320701746248.
- Pressley ZM, Foster JK, Kolm P, Zhao L, Warren F, Weintraub W, Sumpio BE, Chen SC. Digital image analysis: a reliable tool in the quantitative evaluation of cutaneous lesions and beyond. Archives Of Dermatology 2007, 143: 1331-3. PMID: 17938354, DOI: 10.1001/archderm.143.10.1331.
- Pradhan S, Elefteriades JA, Sumpio BE. Utility of the aortic fenestration technique in the management of acute aortic dissections. Annals Of Thoracic And Cardiovascular Surgery : Official Journal Of The Association Of Thoracic And Cardiovascular Surgeons Of Asia 2007, 13: 296-300. PMID: 17954985.
- Aziz F, Spate K, Wong J, Aruny J, Sumpio B. Changing patterns in the use of inferior vena cava filters: review of a single center experience. Journal Of The American College Of Surgeons 2007, 205: 564-9. PMID: 17903730, DOI: 10.1016/j.jamcollsurg.2007.05.026.
- Nishimura K, Blume P, Ohgi S, Sumpio BE. Effect of different frequencies of tensile strain on human dermal fibroblast proliferation and survival. Wound Repair And Regeneration : Official Publication Of The Wound Healing Society [and] The European Tissue Repair Society 2007, 15: 646-56. PMID: 17971010, DOI: 10.1111/j.1524-475X.2007.00295.x.
- Direct comparison of endothelial cell and smooth muscle cell response to supercooling and rewarming.Yiu WK, Cheng SW, Sumpio BE. Direct comparison of endothelial cell and smooth muscle cell response to supercooling and rewarming. Journal Of Vascular Surgery 2007, 46: 557-564. PMID: 17826245, DOI: 10.1016/j.jvs.2007.04.072.
- Kadohama T, Nishimura K, Hoshino Y, Sasajima T, Sumpio BE. Effects of different types of fluid shear stress on endothelial cell proliferation and survival. Journal Of Cellular Physiology 2007, 212: 244-51. PMID: 17323381, DOI: 10.1002/jcp.21024.
- Gumbs AA, Hanan S, Yue JJ, Shah RV, Sumpio B. Revision open anterior approaches for spine procedures. The Spine Journal : Official Journal Of The North American Spine Society 2007, 7: 280-5. PMID: 17482110, DOI: 10.1016/j.spinee.2006.05.015.
- Blume P, Salonga C, Garbalosa J, Pierre-Paul D, Key J, Gahtan V, Sumpio BE. Predictors for the healing of transmetatarsal amputations: retrospective study of 91 amputations. Vascular 2007, 15: 126-33. PMID: 17573017, DOI: 10.2310/6670.2007.00035.
- Yiu WK, Basco MT, Aruny JE, Cheng SW, Sumpio BE. Cryosurgery: A review. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2007, 16: 1-6. PMID: 22477240, PMCID: PMC2732998, DOI: 10.1055/s-0031-1278235.
- Hoshino Y, Nishimura K, Sumpio BE. Phosphatase PTEN is inactivated in bovine aortic endothelial cells exposed to cyclic strain. Journal Of Cellular Biochemistry 2007, 100: 515-26. PMID: 16927376, DOI: 10.1002/jcb.21085.
- Yiu WK, Cheng SW, Sumpio BE. Vascular smooth muscle cell apoptosis induced by "supercooling" and rewarming. Journal Of Vascular And Interventional Radiology : JVIR 2006, 17: 1971-7. PMID: 17185696, DOI: 10.1097/01.RVI.0000244868.65867.FB.
- Fleck T, Gustafsson R, Harding K, Ingemansson R, Lirtzman MD, Meites HL, Moidl R, Price P, Ritchie A, Salazar J, Sjögren J, Song DH, Sumpio BE, Toursarkissian B, Waldenberger F, Wetzel-Roth W. The management of deep sternal wound infections using vacuum assisted closure (V.A.C.) therapy. International Wound Journal 2006, 3: 273-80. PMID: 17199763, PMCID: PMC7951489, DOI: 10.1111/j.1742-481X.2006.00273.x.
- Biswas P, Canosa S, Schoenfeld D, Schoenfeld J, Li P, Cheas LC, Zhang J, Cordova A, Sumpio B, Madri JA. PECAM-1 affects GSK-3beta-mediated beta-catenin phosphorylation and degradation. The American Journal Of Pathology 2006, 169: 314-24. PMID: 16816383, PMCID: PMC1698776, DOI: 10.2353/ajpath.2006.051112.
- Sumpio BE, Cordova AC, Berke-Schlessel DW, Qin F, Chen QH. Green tea, the "Asian paradox," and cardiovascular disease. Journal Of The American College Of Surgeons 2006, 202: 813-25. PMID: 16648021, DOI: 10.1016/j.jamcollsurg.2006.01.018.
- Nishimura K, Li W, Hoshino Y, Kadohama T, Asada H, Ohgi S, Sumpio BE. Role of AKT in cyclic strain-induced endothelial cell proliferation and survival. American Journal Of Physiology. Cell Physiology 2006, 290: C812-21. PMID: 16469863, DOI: 10.1152/ajpcell.00347.2005.
- Weiss JS, Sumpio BE. Review of prevalence and outcome of vascular disease in patients with diabetes mellitus. European Journal Of Vascular And Endovascular Surgery : The Official Journal Of The European Society For Vascular Surgery 2006, 31: 143-50. PMID: 16203161, DOI: 10.1016/j.ejvs.2005.08.015.
- Ueno H, Pradhan S, Schlessel D, Hirasawa H, Sumpio BE. Nicotine enhances human vascular endothelial cell expression of ICAM-1 and VCAM-1 via protein kinase C, p38 mitogen-activated protein kinase, NF-kappaB, and AP-1. Cardiovascular Toxicology 2006, 6: 39-50. PMID: 16845181, DOI: 10.1385/ct:6:1:39.
- Kadohama T, Akasaka N, Nishimura K, Hoshino Y, Sasajima T, Sumpio BE. p38 Mitogen-activated protein kinase activation in endothelial cell is implicated in cell alignment and elongation induced by fluid shear stress. Endothelium : Journal Of Endothelial Cell Research 2006, 13: 43-50. PMID: 16885066, DOI: 10.1080/10623320600660219.
- Poussier B, Cordova AC, Becquemin JP, Sumpio BE. Resveratrol inhibits vascular smooth muscle cell proliferation and induces apoptosis. Journal Of Vascular Surgery 2005, 42: 1190-7. PMID: 16376213, DOI: 10.1016/j.jvs.2005.08.014.
- Liu SQ, Alkema PK, Tieché C, Tefft BJ, Liu DZ, Li YC, Sumpio BE, Caprini JA, Paniagua M. Negative regulation of monocyte adhesion to arterial elastic laminae by signal regulatory protein alpha and Src homology 2 domain-containing protein-tyrosine phosphatase-1. The Journal Of Biological Chemistry 2005, 280: 39294-301. PMID: 16159885, DOI: 10.1074/jbc.M503866200.
- Kudo FA, Warycha B, Juran PJ, Asada H, Teso D, Aziz F, Frattini J, Sumpio BE, Nishibe T, Cha C, Dardik A. Differential responsiveness of early- and late-passage endothelial cells to shear stress. American Journal Of Surgery 2005, 190: 763-9. PMID: 16226955, DOI: 10.1016/j.amjsurg.2005.07.017.
- Asada H, Paszkowiak J, Teso D, Alvi K, Thorisson A, Frattini JC, Kudo FA, Sumpio BE, Dardik A. Sustained orbital shear stress stimulates smooth muscle cell proliferation via the extracellular signal-regulated protein kinase 1/2 pathway. Journal Of Vascular Surgery 2005, 42: 772-80. PMID: 16242567, DOI: 10.1016/j.jvs.2005.05.046.
- Sumpio BE, Aruny J. Commentary. Cilostazol inhibits leukocyte integrin Mac-1, leading to a potential reduction in restenosis after coronary stent implantation. Perspectives In Vascular Surgery And Endovascular Therapy 2005, 17: 265-7. PMID: 16273169, DOI: 10.1177/153100350501700317.
- Kakisis JD, Pradhan S, Cordova A, Liapis CD, Sumpio BE. The role of STAT-3 in the mediation of smooth muscle cell response to cyclic strain. The International Journal Of Biochemistry & Cell Biology 2005, 37: 1396-406. PMID: 15833272, DOI: 10.1016/j.biocel.2005.01.009.
- Dardik A, Chen L, Frattini J, Asada H, Aziz F, Kudo FA, Sumpio BE. Differential effects of orbital and laminar shear stress on endothelial cells. Journal Of Vascular Surgery 2005, 41: 869-80. PMID: 15886673, DOI: 10.1016/j.jvs.2005.01.020.
- Li W, Sumpio BE. Strain-induced vascular endothelial cell proliferation requires PI3K-dependent mTOR-4E-BP1 signal pathway. American Journal Of Physiology. Heart And Circulatory Physiology 2005, 288: H1591-7. PMID: 15591103, DOI: 10.1152/ajpheart.00382.2004.
- Gumbs AA, Shah RV, Yue JJ, Sumpio B. The open anterior paramedian retroperitoneal approach for spine procedures. Archives Of Surgery (Chicago, Ill. : 1960) 2005, 140: 339-43. PMID: 15837883, DOI: 10.1001/archsurg.140.4.339.
- Sumpio BE, Yun S, Cordova AC, Haga M, Zhang J, Koh Y, Madri JA. MAPKs (ERK1/2, p38) and AKT can be phosphorylated by shear stress independently of platelet endothelial cell adhesion molecule-1 (CD31) in vascular endothelial cells. The Journal Of Biological Chemistry 2005, 280: 11185-91. PMID: 15668248, DOI: 10.1074/jbc.M414631200.
- Akasaka K, Akasaka N, Di Luozzo G, Sasajima T, Sumpio BE. Homocysteine promotes p38-dependent chemotaxis in bovine aortic smooth muscle cells. Journal Of Vascular Surgery 2005, 41: 517-22. PMID: 15838488, DOI: 10.1016/j.jvs.2004.12.043.
- Cordova AC, Jackson LS, Berke-Schlessel DW, Sumpio BE. The cardiovascular protective effect of red wine. Journal Of The American College Of Surgeons 2005, 200: 428-39. PMID: 15737855, DOI: 10.1016/j.jamcollsurg.2004.10.030.
- Kakisis JD, Liapis CD, Breuer C, Sumpio BE. Artificial blood vessel: the Holy Grail of peripheral vascular surgery. Journal Of Vascular Surgery 2005, 41: 349-54. PMID: 15768021, DOI: 10.1016/j.jvs.2004.12.026.
- Di Luozzo G, Pradhan S, Dhadwal AK, Chen A, Ueno H, Sumpio BE. Nicotine induces mitogen-activated protein kinase dependent vascular smooth muscle cell migration. Atherosclerosis 2005, 178: 271-7. PMID: 15694934, DOI: 10.1016/j.atherosclerosis.2004.09.017.
- Dardik A, Yamashita A, Aziz F, Asada H, Sumpio BE. Shear stress-stimulated endothelial cells induce smooth muscle cell chemotaxis via platelet-derived growth factor-BB and interleukin-1alpha. Journal Of Vascular Surgery 2005, 41: 321-31. PMID: 15768016, DOI: 10.1016/j.jvs.2004.11.016.
- Esemuede N, Lee T, Pierre-Paul D, Sumpio BE, Gahtan V. The role of thrombospondin-1 in human disease. The Journal Of Surgical Research 2004, 122: 135-42. PMID: 15522326, DOI: 10.1016/j.jss.2004.05.015.
- Abir F, Barkhordarian S, Sumpio BE. Efficacy of dextran solutions in vascular surgery. Vascular And Endovascular Surgery 2004, 38: 483-91. PMID: 15592628, DOI: 10.1177/153857440403800601.
- Jackson LS, Dudrick SJ, Sumpio BE. John Harvey Kellogg; surgeon, inventor, nutritionist (1852-1943). Journal Of The American College Of Surgeons 2004, 199: 817-21. PMID: 15501124, DOI: 10.1016/j.jamcollsurg.2004.05.279.
- Sumpio BE, Aruny J, Blume PA. The multidisciplinary approach to limb salvage. Acta Chirurgica Belgica 2004, 104: 647-53. PMID: 15663269, DOI: 10.1080/00015458.2004.11679637.
- Pradhan S, Sumpio B. Molecular and biological effects of hemodynamics on vascular cells. Frontiers In Bioscience : A Journal And Virtual Library 2004, 9: 3276-85. PMID: 15353357, DOI: 10.2741/1480.
- Lee T, Sumpio BE. Cell signalling in vascular cells exposed to cyclic strain: the emerging role of protein phosphatases. Biotechnology And Applied Biochemistry 2004, 39: 129-39. PMID: 15032733, DOI: 10.1042/BA20030104.
- Pradhan S, Sumpio BE. Do estrogen effects on blood vessels translate into clinically significant atheroprotection? Journal Of The American College Of Surgeons 2004, 198: 462-74. PMID: 14992749, DOI: 10.1016/j.jamcollsurg.2003.09.026.
- Kakisis JD, Liapis CD, Sumpio BE. Effects of cyclic strain on vascular cells. Endothelium : Journal Of Endothelial Cell Research 2004, 11: 17-28. PMID: 15203876, DOI: 10.1080/10623320490432452.
- Willis AI, Pierre-Paul D, Sumpio BE, Gahtan V. Vascular smooth muscle cell migration: current research and clinical implications. Vascular And Endovascular Surgery 2004, 38: 11-23. PMID: 14760473, DOI: 10.1177/153857440403800102.
- Sumpio BE, Lee T, Blume PA. Vascular evaluation and arterial reconstruction of the diabetic foot. Clinics In Podiatric Medicine And Surgery 2003, 20: 689-708. PMID: 14636033, DOI: 10.1016/S0891-8422(03)00088-0.
- Lee L, Blume PA, Sumpio B. Charcot joint disease in diabetes mellitus. Annals Of Vascular Surgery 2003, 17: 571-80. PMID: 14508661, DOI: 10.1007/s10016-003-0039-5.
- Zhang J, Li W, Sumpio BE, Basson MD. Fibronectin blocks p38 and jnk activation by cyclic strain in Caco-2 cells. Biochemical And Biophysical Research Communications 2003, 306: 746-9. PMID: 12810082, DOI: 10.1016/s0006-291x(03)01044-1.
- Lee T, Esemuede N, Sumpio BE, Gahtan V. Thrombospondin-1 induces matrix metalloproteinase-2 activation in vascular smooth muscle cells. Journal Of Vascular Surgery 2003, 38: 147-54. PMID: 12844104, DOI: 10.1016/s0741-5214(02)75468-2.
- Lee T, Nesselroth SM, Olson ET, Esemuede N, Lawler J, Sumpio BE, Gahtan V. Thrombospondin-1-induced vascular smooth muscle cell chemotaxis: the role of the type 3 repeat and carboxyl terminal domains. Journal Of Cellular Biochemistry 2003, 89: 500-6. PMID: 12761883, DOI: 10.1002/jcb.10524.
- Haga M, Yamashita A, Paszkowiak J, Sumpio BE, Dardik A. Oscillatory shear stress increases smooth muscle cell proliferation and Akt phosphorylation. Journal Of Vascular Surgery 2003, 37: 1277-84. PMID: 12764276, DOI: 10.1016/s0741-5214(03)00329-x.
- Kakisis JD, Abir F, Liapis CD, Sumpio BE. An appraisal of different cardiac risk reduction strategies in vascular surgery patients. European Journal Of Vascular And Endovascular Surgery : The Official Journal Of The European Society For Vascular Surgery 2003, 25: 493-504. PMID: 12787690, DOI: 10.1053/ejvs.2002.1851.
- Li W, Chen Q, Mills I, Sumpio BE. Involvement of S6 kinase and p38 mitogen activated protein kinase pathways in strain-induced alignment and proliferation of bovine aortic smooth muscle cells. Journal Of Cellular Physiology 2003, 195: 202-9. PMID: 12652647, DOI: 10.1002/jcp.10230.
- Zhang J, Li W, Sanders MA, Sumpio BE, Panja A, Basson MD. Regulation of the intestinal epithelial response to cyclic strain by extracellular matrix proteins. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2003, 17: 926-8. PMID: 12626437, DOI: 10.1096/fj.02-0663fje.
- Lee T, Seo JW, Sumpio BE, Kim SJ. Immunobiologic analysis of arterial tissue in Buerger's disease. European Journal Of Vascular And Endovascular Surgery : The Official Journal Of The European Society For Vascular Surgery 2003, 25: 451-7. PMID: 12713785, DOI: 10.1053/ejvs.2002.1869.
- Yamashita A, Hanna AK, Hirata S, Dardik A, Sumpio BE. Antisense basic fibroblast growth factor alters the time course of mitogen-activated protein kinase in arterialized vein graft remodeling. Journal Of Vascular Surgery 2003, 37: 866-73. PMID: 12663990, DOI: 10.1067/mva.2003.130.
- Lee T, Kim SJ, Sumpio BE. Role of PP2A in the regulation of p38 MAPK activation in bovine aortic endothelial cells exposed to cyclic strain. Journal Of Cellular Physiology 2003, 194: 349-55. PMID: 12548554, DOI: 10.1002/jcp.10211.
- Chen Q, Li W, Quan Z, Sumpio BE. Modulation of vascular smooth muscle cell alignment by cyclic strain is dependent on reactive oxygen species and P38 mitogen-activated protein kinase. Journal Of Vascular Surgery 2003, 37: 660-8. PMID: 12618707, DOI: 10.1067/mva.2003.95.
- Abir F, Kakisis I, Sumpio B. Do vascular surgery patients need a cardiology work-up? A review of pre-operative cardiac clearance guidelines in vascular surgery. European Journal Of Vascular And Endovascular Surgery : The Official Journal Of The European Society For Vascular Surgery 2003, 25: 110-7. PMID: 12552470, DOI: 10.1053/ejvs.2002.1797.
- Haga M, Chen A, Gortler D, Dardik A, Sumpio BE. Shear stress and cyclic strain may suppress apoptosis in endothelial cells by different pathways. Endothelium : Journal Of Endothelial Cell Research 2003, 10: 149-57. PMID: 13129818, DOI: 10.1080/10623320390233463.
- Renzulli JF, Borromeo JR, Barkhordarian S, Sumpio BE. Abdominal aortic aneurysm in association with a congenital pelvic horseshoe kidney: sentinel report and technical consideration. Vascular Medicine (London, England) 2003, 8: 197-9. PMID: 14989561, DOI: 10.1191/1358863x03vm495cr.
- Sumpio BE, Riley JT, Dardik A. Cells in focus: endothelial cell. The International Journal Of Biochemistry & Cell Biology 2002, 34: 1508-12. PMID: 12379270, DOI: 10.1016/s1357-2725(02)00075-4.
- Lee DM, Gasparro FP, Wang XJ, Kopec C, DeLeo K, Sumpio BE. Photochemotherapy of vascular cells with 8-methoxypsoralen and visible light: differential effects on endothelial and smooth muscle cells. Photodermatology, Photoimmunology & Photomedicine 2002, 18: 244-52. PMID: 12390666, DOI: 10.1034/j.1600-0781.2002.02770.x.
- Yun S, Dardik A, Haga M, Yamashita A, Yamaguchi S, Koh Y, Madri JA, Sumpio BE. Transcription factor Sp1 phosphorylation induced by shear stress inhibits membrane type 1-matrix metalloproteinase expression in endothelium. The Journal Of Biological Chemistry 2002, 277: 34808-14. PMID: 12093818, DOI: 10.1074/jbc.M205417200.
- Yamaguchi S, Yamaguchi M, Yatsuyanagi E, Yun SS, Nakajima N, Madri JA, Sumpio BE. Cyclic strain stimulates early growth response gene product 1-mediated expression of membrane type 1 matrix metalloproteinase in endothelium. Laboratory Investigation; A Journal Of Technical Methods And Pathology 2002, 82: 949-56. PMID: 12118097, DOI: 10.1097/01.lab.0000020408.77307.e9.
- Araim O, Ballantyne J, Waterhouse AL, Sumpio BE. Inhibition of vascular smooth muscle cell proliferation with red wine and red wine polyphenols. Journal Of Vascular Surgery 2002, 35: 1226-32. PMID: 12042735, DOI: 10.1067/mva.2002.124358.
- Thamilselvan V, Li W, Sumpio BE, Basson MD. Sphingosine-1-phosphate stimulates human Caco-2 intestinal epithelial proliferation via p38 activation and activates ERK by an independent mechanism. In Vitro Cellular & Developmental Biology. Animal 2002, 38: 246-53. PMID: 12197778, DOI: 10.1290/1071-2690(2002)038<0246:SPSHCI>2.0.CO;2.
- Frangos SG, Kilaru S, Sumpio BE, Gahtan V. Effect of gender on outcome following infrainguinal bypass graft surgery: a systematic review. Connecticut Medicine 2002, 66: 137-44. PMID: 11957765.
- Gahtan V, Olson ET, Sumpio BE. Molecular biology: a brief overview. Journal Of Vascular Surgery 2002, 35: 563-8. PMID: 11877707, DOI: 10.1067/mva.2002.120039.
- Blume PA, Paragas LK, Sumpio BE, Attinger CE. Single-stage surgical treatment of noninfected diabetic foot ulcers. Plastic And Reconstructive Surgery 2002, 109: 601-9. PMID: 11818842, DOI: 10.1097/00006534-200202000-00029.
- Throckmorton D, Kurscheid-Reich D, Rosales OR, Rodriguez-Commes J, Lopez R, Sumpio B, Zhong Q, Ding KH, McCarthy R, Barrett PQ, Isales CM. Parathyroid hormone effects on signaling pathways in endothelial cells vary with peptide concentration. Peptides 2002, 23: 79-85. PMID: 11814621, DOI: 10.1016/s0196-9781(01)00582-4.
- Kilaru S, Frangos SG, Chen AH, Gortler D, Dhadwal AK, Araim O, Sumpio BE. Nicotine: a review of its role in atherosclerosis. Journal Of The American College Of Surgeons 2001, 193: 538-46. PMID: 11708512, DOI: 10.1016/s1072-7515(01)01059-6.
- Chen AH, Gortler DS, Kilaru S, Araim O, Frangos SG, Sumpio BE. Cyclic strain activates the pro-survival Akt protein kinase in bovine aortic smooth muscle cells. Surgery 2001, 130: 378-81. PMID: 11490374, DOI: 10.1067/msy.2001.116668.
- Chen AH, Frangos SG, Kilaru S, Sumpio BE. Intermittent pneumatic compression devices -- physiological mechanisms of action. European Journal Of Vascular And Endovascular Surgery : The Official Journal Of The European Society For Vascular Surgery 2001, 21: 383-92. PMID: 11352511, DOI: 10.1053/ejvs.2001.1348.
- Nesselroth SM, Willis AI, Fuse S, Olson ET, Lawler J, Sumpio BE, Gahtan V. The C-terminal domain of thrombospondin-1 induces vascular smooth muscle cell chemotaxis. Journal Of Vascular Surgery 2001, 33: 595-600. PMID: 11241132, DOI: 10.1067/mva.2001.112318.
- Azuma N, Akasaka N, Kito H, Ikeda M, Gahtan V, Sasajima T, Sumpio BE. Role of p38 MAP kinase in endothelial cell alignment induced by fluid shear stress. American Journal Of Physiology. Heart And Circulatory Physiology 2001, 280: H189-97. PMID: 11123233, DOI: 10.1152/ajpheart.2001.280.1.H189.
- Li W, Duzgun A, Sumpio BE, Basson MD. Integrin and FAK-mediated MAPK activation is required for cyclic strain mitogenic effects in Caco-2 cells. American Journal Of Physiology. Gastrointestinal And Liver Physiology 2001, 280: G75-87. PMID: 11123200, DOI: 10.1152/ajpgi.2001.280.1.G75.
- Han O, Takei T, Basson M, Sumpio BE. Translocation of PKC isoforms in bovine aortic smooth muscle cells exposed to strain. Journal Of Cellular Biochemistry 2001, 80: 367-72. PMID: 11135367, DOI: 10.1002/1097-4644(20010301)80:3<367::aid-jcb100>3.0.co;2-2.
- Smith JD, Davies N, Willis AI, Sumpio BE, Zilla P. Cyclic stretch induces the expression of vascular endothelial growth factor in vascular smooth muscle cells. Endothelium : Journal Of Endothelial Cell Research 2001, 8: 41-8. PMID: 11409850, DOI: 10.3109/10623320109063156.
- Frangos SG, Knox R, Yano Y, Chen E, Di Luozzo G, Chen AH, Sumpio BE. The integrin-mediated cyclic strain-induced signaling pathway in vascular endothelial cells. Endothelium : Journal Of Endothelial Cell Research 2001, 8: 1-10. PMID: 11409847, DOI: 10.3109/10623320109063153.
- Kito H, Chen EL, Wang X, Ikeda M, Azuma N, Nakajima N, Gahtan V, Sumpio BE. Role of mitogen-activated protein kinases in pulmonary endothelial cells exposed to cyclic strain. Journal Of Applied Physiology (Bethesda, Md. : 1985) 2000, 89: 2391-400. PMID: 11090594, DOI: 10.1152/jappl.2000.89.6.2391.
- Azuma N, Duzgun SA, Ikeda M, Kito H, Akasaka N, Sasajima T, Sumpio BE. Endothelial cell response to different mechanical forces. Journal Of Vascular Surgery 2000, 32: 789-94. PMID: 11013043, DOI: 10.1067/mva.2000.107989.
- Sumpio BE. Foot ulcers. The New England Journal Of Medicine 2000, 343: 787-93. PMID: 10984568, DOI: 10.1056/NEJM200009143431107.
- Woo DK, Dudrick SJ, Sumpio BE. Homocysteine stimulates MAP kinase in bovine aortic smooth muscle cells. Surgery 2000, 128: 59-66. PMID: 10876187, DOI: 10.1067/msy.2000.106531.
- Murnin M, Kumar A, Li GD, Brown M, Sumpio BE, Basson MD. Effects of glutamine isomers on human (Caco-2) intestinal epithelial proliferation, strain-responsiveness, and differentiation. Journal Of Gastrointestinal Surgery : Official Journal Of The Society For Surgery Of The Alimentary Tract 2000, 4: 435-42. PMID: 11058864, DOI: 10.1016/s1091-255x(00)80025-6.
- Fujioka K, Azuma N, Kito H, Gahtan V, Esato K, Sumpio BE. Role of caveolin in hemodynamic force-mediated endothelial changes. The Journal Of Surgical Research 2000, 92: 7-10. PMID: 10864474, DOI: 10.1006/jsre.2000.5838.
- Willis AI, Fuse S, Wang XJ, Chen E, Tuszynski GP, Sumpio BE, Gahtan V. Inhibition of phosphatidylinositol 3-kinase and protein kinase C attenuates extracellular matrix protein-induced vascular smooth muscle cell chemotaxis. Journal Of Vascular Surgery 2000, 31: 1160-7. PMID: 10842153, DOI: 10.1067/mva.2000.106489.
- Basson MD, Yu CF, Herden-Kirchoff O, Ellermeier M, Sanders MA, Merrell RC, Sumpio BE. Effects of increased ambient pressure on colon cancer cell adhesion. Journal Of Cellular Biochemistry 2000, 78: 47-61. PMID: 10797565, DOI: 10.1002/(sici)1097-4644(20000701)78:1<47::aid-jcb5>3.0.co;2-m.
- Collins KA, Sumpio BE. Vascular assessment. Clinics In Podiatric Medicine And Surgery 2000, 17: 171-91. PMID: 10810651.
- Duzgun SA, Rasque H, Kito H, Azuma N, Li W, Basson MD, Gahtan V, Dudrick SJ, Sumpio BE. Mitogen-activated protein phosphorylation in endothelial cells exposed to hyperosmolar conditions. Journal Of Cellular Biochemistry 2000, 76: 567-71. PMID: 10653976, DOI: 10.1002/(sici)1097-4644(20000315)76:4<567::aid-jcb5>3.0.co;2-w.
- Gahtan V, Wang XJ, Willis AI, Tuszynski GP, Sumpio BE. Thrombospondin-1 regulation of smooth muscle cell chemotaxis is extracellular signal-regulated protein kinases 1/2 dependent. Surgery 1999, 126: 203-7. PMID: 10455885.
- Gahtan V, Wang XJ, Ikeda M, Willis AI, Tuszynski GP, Sumpio BE. Thrombospondin-1 induces activation of focal adhesion kinase in vascular smooth muscle cells. Journal Of Vascular Surgery 1999, 29: 1031-6. PMID: 10359937, DOI: 10.1016/s0741-5214(99)70244-2.
- Ikeda M, Kito H, Sumpio BE. Phosphatidylinositol-3 kinase dependent MAP kinase activation via p21ras in endothelial cells exposed to cyclic strain. Biochemical And Biophysical Research Communications 1999, 257: 668-71. PMID: 10208841, DOI: 10.1006/bbrc.1999.0532.
- Li S, Chen BP, Azuma N, Hu YL, Wu SZ, Sumpio BE, Shyy JY, Chien S. Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress. The Journal Of Clinical Investigation 1999, 103: 1141-50. PMID: 10207166, PMCID: PMC408275, DOI: 10.1172/JCI5367.
- Ikeda M, Takei T, Mills I, Kito H, Sumpio BE. Extracellular signal-regulated kinases 1 and 2 activation in endothelial cells exposed to cyclic strain. The American Journal Of Physiology 1999, 276: H614-22. PMID: 9950863, DOI: 10.1152/ajpheart.1999.276.2.h614.
- Kamal K, Du W, Mills I, Sumpio BE. Antiproliferative effect of elevated glucose in human microvascular endothelial cells. Journal Of Cellular Biochemistry 1998, 71: 491-501. PMID: 9827695, DOI: 10.1002/(sici)1097-4644(19981215)71:4<491::aid-jcb4>3.0.co;2-p.
- Quader MA, Stump LS, Sumpio BE. Low molecular weight heparins: current use and indications. Journal Of The American College Of Surgeons 1998, 187: 641-58. PMID: 9849742, DOI: 10.1016/s1072-7515(98)00255-5.
- Han O, Sumpio BE, Basson MD. Mechanical strain rapidly redistributes tyrosine phosphorylated proteins in human intestinal Caco-2 cells. Biochemical And Biophysical Research Communications 1998, 250: 668-73. PMID: 9784404, DOI: 10.1006/bbrc.1998.9372.
- Han O, Li GD, Sumpio BE, Basson MD. Strain induces Caco-2 intestinal epithelial proliferation and differentiation via PKC and tyrosine kinase signals. The American Journal Of Physiology 1998, 275: G534-41. PMID: 9724266, DOI: 10.1152/ajpgi.1998.275.3.G534.
- Segurola RJ, Mills I, Sumpio BE. Strain-induced dual alignment of L6 rat skeletal muscle cells. In Vitro Cellular & Developmental Biology. Animal 1998, 34: 609-12. PMID: 9769140, DOI: 10.1007/s11626-996-0004-z.
- Gahtan V, Peyman JA, Sumpio BE. Understanding molecular biology. Seminars In Vascular Surgery 1998, 11: 125-33. PMID: 9763112.
- Takei T, Mills I, Arai K, Sumpio BE. Molecular basis for tissue expansion: clinical implications for the surgeon. Plastic And Reconstructive Surgery 1998, 102: 247-58. PMID: 9655439, DOI: 10.1097/00006534-199807000-00044.
- Ikeda M, Takei T, Mills I, Sumpio BE. Calcium-independent activation of extracellular signal-regulated kinases 1 and 2 by cyclic strain. Biochemical And Biophysical Research Communications 1998, 247: 462-5. PMID: 9642151, DOI: 10.1006/bbrc.1998.8811.
- Sawmiller CJ, Powell RJ, Quader M, Dudrick SJ, Sumpio BE. The differential effect of contrast agents on endothelial cell and smooth muscle cell growth in vitro. Journal Of Vascular Surgery 1998, 27: 1128-40. PMID: 9652475, DOI: 10.1016/s0741-5214(98)70015-1.
- Takei T, Kito H, Du W, Mills I, Sumpio BE. Induction of interleukin (IL)-1 alpha and beta gene expression in human keratinocytes exposed to repetitive strain: their role in strain-induced keratinocyte proliferation and morphological change. Journal Of Cellular Biochemistry 1998, 69: 95-103. PMID: 9548558.
- Sawyer MD, van Raaij T, Cross J, Sumpio BE. Novel potentiation of interleukin 1alpha production in endotoxin-stimulated IC-21 cells by ambient pressure augmentation. Archives Of Surgery (Chicago, Ill. : 1960) 1998, 133: 438-41. PMID: 9565126, DOI: 10.1001/archsurg.133.4.438.
- Sumpio BE, Du W, Galagher G, Wang X, Khachigian LM, Collins T, Gimbrone MA, Resnick N. Regulation of PDGF-B in endothelial cells exposed to cyclic strain. Arteriosclerosis, Thrombosis, And Vascular Biology 1998, 18: 349-55. PMID: 9514402, DOI: 10.1161/01.atv.18.3.349.
- Vouyouka AG, Powell RJ, Ricotta J, Chen H, Dudrick DJ, Sawmiller CJ, Dudrick SJ, Sumpio BE. Ambient pulsatile pressure modulates endothelial cell proliferation. Journal Of Molecular And Cellular Cardiology 1998, 30: 609-15. PMID: 9515036, DOI: 10.1006/jmcc.1997.0625.
- Powell RJ, Bhargava J, Basson MD, Sumpio BE. Coculture conditions alter endothelial modulation of TGF-beta 1 activation and smooth muscle growth morphology. The American Journal Of Physiology 1998, 274: H642-9. PMID: 9486269, DOI: 10.1152/ajpheart.1998.274.2.H642.
- Kito H, Yokoyama C, Inoue H, Tanabe T, Nakajima N, Sumpio BE. Cyclooxygenase expression in bovine aortic endothelial cells exposed to cyclic strain. Endothelium : Journal Of Endothelial Cell Research 1998, 6: 107-12. PMID: 9930644, DOI: 10.3109/10623329809072197.
- Schneider SW, Pagel P, Storck J, Yano Y, Sumpio BE, Geibel JP, Oberleithner H. Atomic force microscopy on living cells: aldosterone-induced localized cell swelling. Kidney & Blood Pressure Research 1998, 21: 256-8. PMID: 9762848, DOI: 10.1159/000025869.
- Takei T, Han O, Ikeda M, Male P, Mills I, Sumpio BE. Cyclic strain stimulates isoform-specific PKC activation and translocation in cultured human keratinocytes. Journal Of Cellular Biochemistry 1997, 67: 327-37. PMID: 9361188, DOI: 10.1002/(sici)1097-4644(19971201)67:3<327::aid-jcb5>3.0.co;2-y.
- Schneider SW, Yano Y, Sumpio BE, Jena BP, Geibel JP, Gekle M, Oberleithner H. Rapid aldosterone-induced cell volume increase of endothelial cells measured by the atomic force microscope. Cell Biology International 1997, 21: 759-68. PMID: 9768474, DOI: 10.1006/cbir.1997.0220.
- Sumpio BE, Chang R, Xu WJ, Wang XJ, Du W. Regulation of tPA in endothelial cells exposed to cyclic strain: role of CRE, AP-2, and SSRE binding sites. The American Journal Of Physiology 1997, 273: C1441-8. PMID: 9374627, DOI: 10.1152/ajpcell.1997.273.5.C1441.
- Takei T, Rivas-Gotz C, Delling CA, Koo JT, Mills I, McCarthy TL, Centrella M, Sumpio BE. Effect of strain on human keratinocytes in vitro. Journal Of Cellular Physiology 1997, 173: 64-72. PMID: 9326450, DOI: 10.1002/(SICI)1097-4652(199710)173:1<64::AID-JCP8>3.0.CO;2-H.
- Rosales OR, Isales CM, Barrett PQ, Brophy C, Sumpio BE. Exposure of endothelial cells to cyclic strain induces elevations of cytosolic Ca2+ concentration through mobilization of intracellular and extracellular pools. The Biochemical Journal 1997, 326 ( Pt 2): 385-92. PMID: 9291109, PMCID: PMC1218682, DOI: 10.1042/bj3260385.
- Powell RJ, Roddy SP, Meier GH, Gusberg RJ, Conte MS, Sumpio BE. Effect of renal insufficiency on outcome following infrarenal aortic surgery. American Journal Of Surgery 1997, 174: 126-30. PMID: 9293827, DOI: 10.1016/s0002-9610(97)00069-x.
- Sai Sudhakar CB, al-Hakeem M, Sumpio BE. Venous obstruction of the lower extremity secondary to an enlarged bladder. Connecticut Medicine 1997, 61: 459-60. PMID: 9309893.
- Sudhakar CB, Al-Hakeem M, MacArthur JD, Sumpio BE. Mesenteric ischemia secondary to cocaine abuse: case reports and literature review. The American Journal Of Gastroenterology 1997, 92: 1053-4. PMID: 9177533.
- Chang R, Powell RJ, Sumpio BE. Tissue plasminogen activator-biologic perspective for surgeons. Journal Of The American College Of Surgeons 1997, 184: 529-39. PMID: 9145078.
- Segurola RJ, Oluwole B, Mills I, Yokoyama C, Tanabe T, Kito H, Nakajima N, Sumpio BE. Cyclic strain is a weak inducer of prostacyclin synthase expression in bovine aortic endothelial cells. The Journal Of Surgical Research 1997, 69: 135-8. PMID: 9202659, DOI: 10.1006/jsre.1997.5050.
- Powell RJ, Hydowski J, Frank O, Bhargava J, Sumpio BE. Endothelial cell effect on smooth muscle cell collagen synthesis. The Journal Of Surgical Research 1997, 69: 113-8. PMID: 9202656, DOI: 10.1006/jsre.1997.5045.
- Mills I, Cohen CR, Kamal K, Li G, Shin T, Du W, Sumpio BE. Strain activation of bovine aortic smooth muscle cell proliferation and alignment: study of strain dependency and the role of protein kinase A and C signaling pathways. Journal Of Cellular Physiology 1997, 170: 228-34. PMID: 9066778, DOI: 10.1002/(SICI)1097-4652(199703)170:3<228::AID-JCP2>3.0.CO;2-Q.
- Yano Y, Geibel J, Sumpio BE. Cyclic strain induces reorganization of integrin alpha 5 beta 1 and alpha 2 beta 1 in human umbilical vein endothelial cells. Journal Of Cellular Biochemistry 1997, 64: 505-13. PMID: 9057108, DOI: 10.1002/(sici)1097-4644(19970301)64:3<505::aid-jcb17>3.0.co;2-e.
- Cohen CR, Mills I, Du W, Kamal K, Sumpio BE. Activation of the adenylyl cyclase/cyclic AMP/protein kinase A pathway in endothelial cells exposed to cyclic strain. Experimental Cell Research 1997, 231: 184-9. PMID: 9056425, DOI: 10.1006/excr.1996.3450.
- Evans L, Frenkel L, Brophy CM, Rosales O, Sudhaker CB, Li G, Du W, Sumpio BE. Activation of diacylglycerol in cultured endothelial cells exposed to cyclic strain. The American Journal Of Physiology 1997, 272: C650-6. PMID: 9124309, DOI: 10.1152/ajpcell.1997.272.2.C650.
- Oluwole BO, Du W, Mills I, Sumpio BE. Gene regulation by mechanical forces. Endothelium : Journal Of Endothelial Cell Research 1997, 5: 85-93. PMID: 9237042, DOI: 10.3109/10623329709079866.
- Watase M, Awolesi MA, Ricotta J, Sumpio BE. Effect of pressure on cultured smooth muscle cells. Life Sciences 1997, 61: 987-96. PMID: 9296337, DOI: 10.1016/s0024-3205(97)00603-6.
- Murata K, Mills I, Sumpio BE. Protein phosphatase 2A in stretch-induced endothelial cell proliferation. Journal Of Cellular Biochemistry 1996, 63: 311-9. PMID: 8913882, DOI: 10.1002/(SICI)1097-4644(19961201)63:3%3C311::AID-JCB6%3E3.0.CO;2-#.
- Kamal K, Powell RJ, Sumpio BE. The pathobiology of diabetes mellitus: implications for surgeons. Journal Of The American College Of Surgeons 1996, 183: 271-89. PMID: 8784324.
- Yano Y, Geibel J, Sumpio BE. Tyrosine phosphorylation of pp125FAK and paxillin in aortic endothelial cells induced by mechanical strain. The American Journal Of Physiology 1996, 271: C635-49. PMID: 8770005, DOI: 10.1152/ajpcell.1996.271.2.C635.
- Basson MD, Li GD, Hong F, Han O, Sumpio BE. Amplitude-dependent modulation of brush border enzymes and proliferation by cyclic strain in human intestinal Caco-2 monolayers. Journal Of Cellular Physiology 1996, 168: 476-88. PMID: 8707883, DOI: 10.1002/(SICI)1097-4652(199608)168:2<476::AID-JCP26>3.0.CO;2-#.
- Yano Y, Saito Y, Narumiya S, Sumpio BE. Involvement of rho p21 in cyclic strain-induced tyrosine phosphorylation of focal adhesion kinase (pp125FAK), morphological changes and migration of endothelial cells. Biochemical And Biophysical Research Communications 1996, 224: 508-15. PMID: 8702419, DOI: 10.1006/bbrc.1996.1057.
- Powell RJ, Carruth JA, Basson MD, Bloodgood R, Sumpio BE. Matrix-specific effect of endothelial control of smooth muscle cell migration. Journal Of Vascular Surgery 1996, 24: 51-7. PMID: 8691527, DOI: 10.1016/s0741-5214(96)70144-1.
- Koo JT, Sawyer MD, Powell RJ, Sumpio BE. Transcriptional regulation of endothelin. Surgical Technology International 1996, 5: 276-82. PMID: 15858752.
- Du W, Mills I, Sumpio BE. Cyclic strain causes heterogeneous induction of transcription factors, AP-1, CRE binding protein and NF-kB, in endothelial cells: species and vascular bed diversity. Journal Of Biomechanics 1995, 28: 1485-91. PMID: 8666588, DOI: 10.1016/0021-9290(95)00096-8.
- Awolesi MA, Sessa WC, Sumpio BE. Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells. The Journal Of Clinical Investigation 1995, 96: 1449-54. PMID: 7544806, PMCID: PMC185768, DOI: 10.1172/JCI118181.
- McMillen MA, Sumpio BE. Endothelins: polyfunctional cytokines. Journal Of The American College Of Surgeons 1995, 180: 621-37. PMID: 7749544.
- Oluwole BO, McMIllen M, Sumpio BE. Endothelial cell control of vasomotor tone. Annals Of Vascular Surgery 1995, 9: 293-301. PMID: 7543275, DOI: 10.1007/BF02135291.
- McMillen MA, Huribal M, Cunningham ME, Kumar R, Sumpio BE. Endothelin-1 increases intracellular calcium in human monocytes and causes production of interleukin-6. Critical Care Medicine 1995, 23: 34-40. PMID: 8001384, DOI: 10.1097/00003246-199501000-00009.
- McMillen MA, Sumpio BE. Endothelial-leukocyte interactions in the neutrophil cascade. American Journal Of Surgery 1995, 169: 186-7. PMID: 7817990, DOI: 10.1016/s0002-9610(99)80130-5.
- Gusberg RJ, Peterec SM, Sumpio BE, Meier GH. Splenomegaly and variceal bleeding--hemodynamic basis and treatment implications. Hepato-gastroenterology 1994, 41: 573-7. PMID: 7721248.
- Mills I, Murata K, Packer CS, Sumpio BE. Cyclic strain stimulates dephosphorylation of the 20kDa regulatory myosin light chain in vascular smooth muscle cells. Biochemical And Biophysical Research Communications 1994, 205: 79-84. PMID: 7999114, DOI: 10.1006/bbrc.1994.2632.
- Sumpio BE, Li G, Deckelbaum LI, Gasparro FP. Inhibition of smooth muscle cell proliferation by visible light-activated psoralen. Circulation Research 1994, 75: 208-13. PMID: 8033334, DOI: 10.1161/01.res.75.2.208.
- Awolesi MA, Widmann MD, Sessa WC, Sumpio BE. Cyclic strain increases endothelial nitric oxide synthase activity. Surgery 1994, 116: 439-44; discussion 444-5. PMID: 7519368.
- Huribal M, Kumar R, Cunningham ME, Sumpio BE, McMillen MA. Endothelin-stimulated monocyte supernatants enhance neutrophil superoxide production. Shock (Augusta, Ga.) 1994, 1: 184-7. PMID: 7735949, DOI: 10.1097/00024382-199403000-00005.
- Gollin G, Ward B, Meier GH, Sumpio BE, Gusberg RJ. Central splanchnic venous thrombosis. Often unsuspected, usually uncomplicated. Journal Of Clinical Gastroenterology 1994, 18: 109-13. PMID: 8189002, DOI: 10.1097/00004836-199403000-00005.
- Sumpio BE, Widmann MD, Ricotta J, Awolesi MA, Watase M. Increased ambient pressure stimulates proliferation and morphologic changes in cultured endothelial cells. Journal Of Cellular Physiology 1994, 158: 133-9. PMID: 8263020, DOI: 10.1002/jcp.1041580117.
- Wiersbitzky M, Mills I, Sumpio BE, Gewirtz H. Chronic cyclic strain reduces adenylate cyclase activity and stimulatory G protein subunit levels in coronary smooth muscle cells. Experimental Cell Research 1994, 210: 52-5. PMID: 8269996, DOI: 10.1006/excr.1994.1008.
- Widmann MD, Sumpio BE. Lipoprotein (a): a risk factor for peripheral vascular disease. Annals Of Vascular Surgery 1993, 7: 446-51. PMID: 8268090, DOI: 10.1007/BF02002128.
- Wang ZG, Li G, Wu J, Du W, Pu L, Zhang H, Wang D, Sumpio BE. Enhanced patency of venous Dacron grafts by endothelial cell sodding. Annals Of Vascular Surgery 1993, 7: 429-36. PMID: 8268088, DOI: 10.1007/BF02002126.
- Brophy CM, Evans L, Sumpio BE. Defecation syncope secondary to functional inferior vena caval obstruction during a Valsalva maneuver. Annals Of Vascular Surgery 1993, 7: 374-7. PMID: 8268080, DOI: 10.1007/BF02002893.
- Gasparro FP, Gattolin P, Olack GA, Deckelbaum LI, Sumpio BE. The excitation of 8-methoxypsoralen with visible light: reversed phase HPLC quantitation of monoadducts and cross-links. Photochemistry And Photobiology 1993, 57: 1007-10. PMID: 8367529, DOI: 10.1111/j.1751-1097.1993.tb02963.x.
- Sumpio BE, Phan SM, Gasparro FP, Deckelbaum LI. Control of smooth muscle cell proliferation by psoralen photochemotherapy. Journal Of Vascular Surgery 1993, 17: 1010-6; discussion 1016-8. PMID: 8505779, DOI: 10.1067/mva.1993.45747.
- McMillen MA, Huribal M, Kumar R, Sumpio BE. Endothelin-stimulated human monocytes produce prostaglandin E2 but not leukotriene B4. The Journal Of Surgical Research 1993, 54: 331-5. PMID: 8392650, DOI: 10.1006/jsre.1993.1053.
- Brophy CM, Mills I, Rosales O, Isales C, Sumpio BE. Phospholipase C: a putative mechanotransducer for endothelial cell response to acute hemodynamic changes. Biochemical And Biophysical Research Communications 1993, 190: 576-81. PMID: 8427600, DOI: 10.1006/bbrc.1993.1087.
- Deckelbaum LI, Scott JJ, Stetz ML, O'Brien KM, Sumpio BE, Madri JA, Bell L. Photoinhibition of smooth muscle cell migration: potential therapy for restenosis. Lasers In Surgery And Medicine 1993, 13: 4-11. PMID: 8426525, DOI: 10.1002/lsm.1900130104.
- Rosales OR, Isales C, Nathanson M, Sumpio BE. Immunocytochemical expression and localization of protein kinase C in bovine aortic endothelial cells. Biochemical And Biophysical Research Communications 1992, 189: 40-6. PMID: 1449492, DOI: 10.1016/0006-291x(92)91522-r.
- Widmann MD, Letsou GV, Phan S, Baldwin JC, Sumpio BE. Isolation and characterization of rabbit cardiac endothelial cells: response to cyclic strain and growth factors in vitro. The Journal Of Surgical Research 1992, 53: 331-4. PMID: 1405613, DOI: 10.1016/0022-4804(92)90057-7.
- Rosales OR, Sumpio BE. Protein kinase C is a mediator of the adaptation of vascular endothelial cells to cyclic strain in vitro. Surgery 1992, 112: 459-66. PMID: 1379381.
- Iba T, Mills I, Sumpio BE. Intracellular cyclic AMP levels in endothelial cells subjected to cyclic strain in vitro. The Journal Of Surgical Research 1992, 52: 625-30. PMID: 1326680, DOI: 10.1016/0022-4804(92)90140-u.
- Sumpio BE. Molecular biology of the vascular system: fundamental concepts and the tools. Journal Of Vascular Surgery 1992, 15: 906-7. PMID: 1578561, DOI: 10.1016/0741-5214(92)90743-r.
- Rosales OR, Sumpio BE. Changes in cyclic strain increase inositol trisphosphate and diacylglycerol in endothelial cells. The American Journal Of Physiology 1992, 262: C956-62. PMID: 1566821, DOI: 10.1152/ajpcell.1992.262.4.C956.
- Widmann MD, Sumpio BE. Persistent hypoglossal artery: An anomaly leading to false-positive carotid duplex sonography. Annals Of Vascular Surgery 1992, 6: 176-8. PMID: 1599838, DOI: 10.1007/BF02042743.
- Iba T, Sumpio BE. Tissue plasminogen activator expression in endothelial cells exposed to cyclic strain in vitro. Cell Transplantation 1992, 1: 43-50. PMID: 1285345, DOI: 10.1177/096368979200100108.
- Sumpio BE, Phan S. Nephrotoxic potential of FK 506. Transplantation Proceedings 1991, 23: 2789-90. PMID: 1721278.
- Iba T, Maitz S, Furbert T, Rosales O, Widmann MD, Spillane B, Shin T, Sonoda T, Sumpio BE. Effect of cyclic stretch on endothelial cells from different vascular beds. Circulatory Shock 1991, 35: 193-8. PMID: 1777956.
- Iba T, Sumpio BE. Morphological response of human endothelial cells subjected to cyclic strain in vitro. Microvascular Research 1991, 42: 245-54. PMID: 1779881, DOI: 10.1016/0026-2862(91)90059-k.
- Rodriguez R, Stepke M, Maitz S, Cuono CB, Sumpio BE. Amelioration of renal ischemic injury by phosphocreatine. The Journal Of Surgical Research 1991, 51: 271-4. PMID: 1921364, DOI: 10.1016/0022-4804(91)90106-v.
- Sumpio BE. Hemodynamic forces and the biology of the endothelium: signal transduction pathways in endothelial cells subjected to physical forces in vitro. Journal Of Vascular Surgery 1991, 13: 744-6. PMID: 2027223, DOI: 10.1016/0741-5214(91)90372-2.
- Iba T, Shin T, Sonoda T, Rosales O, Sumpio BE. Stimulation of endothelial secretion of tissue-type plasminogen activator by repetitive stretch. The Journal Of Surgical Research 1991, 50: 457-60. PMID: 1903823, DOI: 10.1016/0022-4804(91)90024-g.
- Garrand TJ, Stetz ML, O'Brien KM, Gindi GR, Sumpio BE, Deckelbaum LI. Design and evaluation of a fiberoptic fluorescence guided laser recanalization system. Lasers In Surgery And Medicine 1991, 11: 106-16. PMID: 2034008, DOI: 10.1002/lsm.1900110204.
- Stimulation of adenylate cyclase activity in cultured endothelial cells subjected to cyclic stretch.Letsou GV, Rosales O, Maitz S, Vogt A, Sumpio BE. Stimulation of adenylate cyclase activity in cultured endothelial cells subjected to cyclic stretch. The Journal Of Cardiovascular Surgery 1990, 31: 634-9. PMID: 2229164.
- Sumpio BE, Widmann MD. Enhanced production of endothelium-derived contracting factor by endothelial cells subjected to pulsatile stretch. Surgery 1990, 108: 277-81; discussion 281-2. PMID: 2200155.
- Sumpio BE, Banes AJ, Link GW, Iba T. Modulation of endothelial cell phenotype by cyclic stretch: inhibition of collagen production. The Journal Of Surgical Research 1990, 48: 415-20. PMID: 2352417, DOI: 10.1016/0022-4804(90)90005-m.
- Sumpio BE, Upchurch GR, Johnson G. The influence of perfusate viscosity, RBC deformability and drag on the function of an isolated perfused rat kidney. The Journal Of Surgical Research 1989, 46: 4-8. PMID: 2915534, DOI: 10.1016/0022-4804(89)90174-1.
- Sumpio BE, Banes AJ, Link WG, Johnson G. Enhanced collagen production by smooth muscle cells during repetitive mechanical stretching. Archives Of Surgery (Chicago, Ill. : 1960) 1988, 123: 1233-6. PMID: 3178470, DOI: 10.1001/archsurg.1988.01400340059010.
- Sumpio BE, Banes AJ. Prostacyclin synthetic activity in cultured aortic endothelial cells undergoing cyclic mechanical deformation. Surgery 1988, 104: 383-9. PMID: 3135629.
- Buckley MJ, Banes AJ, Levin LG, Sumpio BE, Sato M, Jordan R, Gilbert J, Link GW, Tran Son Tay R. Osteoblasts increase their rate of division and align in response to cyclic, mechanical tension in vitro. Bone And Mineral 1988, 4: 225-36. PMID: 2847838.
- Sumpio BE, Banes AJ. Response of porcine aortic smooth muscle cells to cyclic tensional deformation in culture. The Journal Of Surgical Research 1988, 44: 696-701. PMID: 3379947, DOI: 10.1016/0022-4804(88)90103-5.
- Sumpio BE, O'Leary G, Gusberg RJ. Variceal bleeding, hypersplenism, and systemic mastocytosis. Pathophysiology and management. Archives Of Surgery (Chicago, Ill. : 1960) 1988, 123: 767-9. PMID: 3130825, DOI: 10.1001/archsurg.1988.01400300113020.
- Sumpio BE. Cyclosporine toxicity in the isolated perfused rat kidney. Transplantation Proceedings 1988, 20: 712-6. PMID: 3388509.
- Sumpio BE, Banes AJ, Buckley M, Johnson G. Alterations in aortic endothelial cell morphology and cytoskeletal protein synthesis during cyclic tensional deformation. Journal Of Vascular Surgery 1988, 7: 130-8. PMID: 3336119.
- Sumpio BE, Baue AE, Chaudry IH. Alleviation of cyclosporine nephrotoxicity with verapamil and ATP-MgCl2. Mitochondrial respiratory and calcium studies. Annals Of Surgery 1987, 206: 655-60. PMID: 3499878, PMCID: PMC1493310, DOI: 10.1097/00000658-198711000-00017.
- Sumpio BE, Gusberg RJ. Aortic thrombosis with paraplegia: an unusual consequence of blunt abdominal trauma. Journal Of Vascular Surgery 1987, 6: 412-4. PMID: 3309383, DOI: 10.1067/mva.1987.avs0060412.
- Sumpio BE, Banes AJ, Levin LG, Johnson G. Mechanical stress stimulates aortic endothelial cells to proliferate. Journal Of Vascular Surgery 1987, 6: 252-6. PMID: 3625881.
- Sumpio BE, Jennings TA, Merino MJ, Sullivan PD. Adenoid cystic carcinoma of the breast. Data from the Connecticut Tumor Registry and a review of the literature. Annals Of Surgery 1987, 205: 295-301. PMID: 3030200, PMCID: PMC1492723, DOI: 10.1097/00000658-198703000-00013.
- Sumpio BE, Hull MJ, Baue AE, Chaudry IH. Comparison of effects of ATP-MgCl2 and adenosine-MgCl2 on renal function following ischemia. The American Journal Of Physiology 1987, 252: R388-93. PMID: 3492930, DOI: 10.1152/ajpregu.1987.252.2.R388.
- Sumpio BE, Dwyer JM, Flye MW. T-lymphocyte subsets in renal allograft recipients treated with cyclosporine and azathioprine. Annals Of Surgery 1987, 205: 49-53. PMID: 3541801, PMCID: PMC1492880, DOI: 10.1097/00000658-198701000-00009.
- Sumpio BE, Hull MJ, Baue AE, Chaudry IH. Effects of ATP-MgCl2 and adenosine-MgCl2 administration on intracellular ATP levels in the kidney. Biochimica Et Biophysica Acta 1986, 862: 303-8. PMID: 3778894, DOI: 10.1016/0005-2736(86)90232-4.
- T-lymphocyte subsets in renal allograft recipients undergoing different immunosuppression protocols.Sumpio BE, Dwyer JM, Flye MW. T-lymphocyte subsets in renal allograft recipients undergoing different immunosuppression protocols. Current Surgery 1986, 43: 502-5. PMID: 3542396.
- Sumpio BE, Ballantyne GH, Zdon MJ, Modlin IM. Perforated appendicitis and obstructing colonic carcinoma in the elderly. Diseases Of The Colon And Rectum 1986, 29: 668-70. PMID: 3757711, DOI: 10.1007/bf02560335.
- Morse SS, Strauss EB, Sumpio BE. Apparent arterial occlusion due to pneumatic antishock garment: pitfall in trauma angiography (case report). AJR. American Journal Of Roentgenology 1986, 147: 391-2. PMID: 3487959, DOI: 10.2214/ajr.147.2.391.
- Sumpio BE, Traquina DN, Gusberg RJ. Results of aortic grafting in occlusive vs aneurysmal disease. Archives Of Surgery (Chicago, Ill. : 1960) 1985, 120: 817-9. PMID: 4015373, DOI: 10.1001/archsurg.1985.01390310055012.
- Sumpio BE, Chaudry IH, Baue AE. Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. II. Effects on gentamicin-treated isolated perfused kidneys. The Journal Of Surgical Research 1985, 38: 438-45. PMID: 3872964, DOI: 10.1016/0022-4804(85)90059-9.
- Sumpio BE, Chaudry IH, Baue AE. Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. 1. Effects on the cis-diamminedichloroplatinum-treated isolated perfused kidneys. The Journal Of Surgical Research 1985, 38: 429-37. PMID: 3872963, DOI: 10.1016/0022-4804(85)90058-7.
- Sumpio BE, Chaudry IH, Baue AE. Adenosine triphosphate--magnesium chloride ameliorates reperfusion injury following ischemia as determined by phosphorus nuclear magnetic resonance. Archives Of Surgery (Chicago, Ill. : 1960) 1985, 120: 233-40. PMID: 3872113, DOI: 10.1001/archsurg.1985.01390260091013.
- Sumpio BE, Chaudry IH, Clemens MG, Baue AE. Accelerated functional recovery of isolated rat kidney with ATP-MgCl2 after warm ischemia. The American Journal Of Physiology 1984, 247: R1047-53. PMID: 6334446, DOI: 10.1152/ajpregu.1984.247.6.R1047.
- Camargo MJ, Sumpio BE, Maack T. Renal hydrolysis of absorbed protein: influence of load and lysosomal pH. The American Journal Of Physiology 1984, 247: F656-64. PMID: 6093557, DOI: 10.1152/ajprenal.1984.247.4.F656.
- Sumpio BE, Ernstoff MS, Kirkwood JM. Urinary excretion of interferon, albumin, and beta 2-microglobulin during interferon treatment. Cancer Research 1984, 44: 3599-603. PMID: 6378373.
- Camargo MJ, Sumpio BE, Maack T. Kinetics of renal catabolism of absorbed proteins: influence of lysosomal pH. Contributions To Nephrology 1984, 42: 19-29. PMID: 6099789, DOI: 10.1159/000409957.
- Sumpio BE, Maack T. Kinetics, competition, and selectivity of tubular absorption of proteins. The American Journal Of Physiology 1982, 243: F379-92. PMID: 7124951, DOI: 10.1152/ajprenal.1982.243.4.F379.
Biography
Bauer Sumpio, MD, PhD, is a vascular surgeon who specializes in the care of patients with diseases of their arteries and veins. He engages in the limb salvage of people with diabetes who are at risk for losing their legs to their diabetic complications. He has decades of experience improving quality of life for patients with plaque build-up in major blood vessels which hinder flow to the critical organs, such as the kidneys, intestine (mesenteric ischemia), legs (claudication and critical limb ischemia) and brain (carotid artery disease).
According to Dr. Sumpio, vascular surgery has become a much less invasive procedure in recent years. He gives credit to the development of endovascular therapeutic techniques, which allow doctors to treat problems from inside the affected blood vessel. Surgeons are able to operate through small punctures of an artery, using tiny, flexible tubes, called catheters, to access the blood vessels. “This means we can fix things from the inside without having to open up the abdomen, chest or neck,” Dr. Sumpio says. These techniques are useful not only in opening up blockages in the artery with a balloon or stent but also for repair of abnormal weakening of the walls of the artery (aneurysm). “Most important for the patient is to have a surgeon who is not only skilled in these endovascular interventions but is capable of performing open surgical procedures when it is appropriate and indicated.”
Other conditions that Dr. Sumpio is skilled in treating include varicose veins using minimal invasive procedures such as laser or radio-frequency to remove dysfunctional veins or varicose veins.
Over his many years of caring for patients, Dr. Sumpio says he has come to understand that “the most important quality a physician can have is compassion. Once a patient trusts you, they understand you will make the best decision in their interest.”
As a professor of vascular surgery at Yale School of Medicine, Dr. Sumpio has also performed basic research on blood flow and how it can affect the vascular wall.
Titles
- Professor of Surgery (Vascular) and of Radiology and Biomedical Imaging and of Medicine (Cardiology)
- Associate Director, Graduate Medical Education
Education & Training
- FellowUniversity of North Carolina, North Carolina Memorial Hospital, Chapel Hill, NC (1987)
- ResidentYale-New Haven Hospital, New Haven, CT (1986)
- PhDCornell University (1981)
- MDCornell University (1980)
Languages Spoken
- English
- Wikang Filipino (Filipino)
Additional Information
- Kim TI, Mena C, Sumpio BE. The Role of Lower Extremity Amputation in Chronic Limb-Threatening Ischemia. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2020, 29: 149-155. PMID: 32904807, PMCID: PMC7458760, DOI: 10.1055/s-0040-1710075.
- Rajaee S, Holder T, Indes JE, Muhs B, Sarac T, Sumpio B, Toll BA, Ochoa Chaar CI. A Pilot Study of a Standardized Smoking Cessation Intervention for Patients with Vascular Disease. Annals Of Vascular Surgery 2019, 61: 91-99.e3. PMID: 31449932, DOI: 10.1016/j.avsg.2019.06.017.
- Brahmandam A, Skrip L, Mojibian H, Aruny J, Sumpio B, Dardik A, Sarac T, Ochoa Chaar CI. Costs and complications of endovascular inferior vena cava filter retrieval. Journal Of Vascular Surgery. Venous And Lymphatic Disorders 2019, 7: 653-659.e1. PMID: 31307952, DOI: 10.1016/j.jvsv.2019.02.017.
- Aurshina A, Zhang Y, Zhuo H, Cardella J, Orion K, Sumpio B, Sarac T, Ochoa Chaar CI. Safety and efficacy of venous ablation in octogenarians. Journal Of Vascular Surgery. Venous And Lymphatic Disorders 2019, 7: 685-692. PMID: 31421837, DOI: 10.1016/j.jvsv.2019.05.006.
- Miller SM, Sumpio BJ, Miller MS, Erben Y, Cordova AC, Sumpio BE. Higher Inpatient Mortality for Women after Intervention for Lifestyle Limiting Claudication. Annals Of Vascular Surgery 2019, 58: 54-62. PMID: 30910650, DOI: 10.1016/j.avsg.2019.01.006.
- Brahmandam A, Skrip L, Sumpio B, Indes J, Dardik A, Sarac T, Rectenwald J, Chaar CIO. A survey of vascular specialists' practice patterns of inferior vena cava filter placement and retrieval. Vascular 2019, 27: 291-298. PMID: 30501583, DOI: 10.1177/1708538118815394.
- Kim TI, Sumpio BE. Management of Asymptomatic Popliteal Artery Aneurysms. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2019, 28: 5-10. PMID: 30880884, PMCID: PMC6417913, DOI: 10.1055/s-0038-1676792.
- Wu RT, Sumpio BJ, Miller S, Sumpio BE. Use of Closed-Incision Negative-Pressure Therapy: Cardiothoracic and Vascular Surgery. Plastic And Reconstructive Surgery 2019, 143: 31S-35S. PMID: 30586101, DOI: 10.1097/PRS.0000000000005310.
- Chitragari G, Shalaby SY, Sumpio BJ, Kurita J, Sumpio BE. Regulation of Yes-Associated Protein by Laminar Flow. Annals Of Vascular Surgery 2018, 52: 183-191. PMID: 29758328, DOI: 10.1016/j.avsg.2018.03.002.
- Aurshina A, Zhang Y, Wang F, Cardella J, Orion K, Sumpio B, Sarac T, Ochoa Chaar CI. The effect of increasing catheter distance from the deep junction on the outcomes of radiofrequency vein ablation. Journal Of Vascular Surgery. Venous And Lymphatic Disorders 2018, 6: 614-620. PMID: 29784594, DOI: 10.1016/j.jvsv.2018.04.006.
- Erben Y, Protack CD, Jean RA, Sumpio BJ, Miller SM, Liu S, Trejo G, Sumpio BE. Endovascular interventions decrease length of hospitalization and are cost-effective in acute mesenteric ischemia. Journal Of Vascular Surgery 2018, 68: 459-469. PMID: 29459015, DOI: 10.1016/j.jvs.2017.11.078.
- Erben Y, Miller SM, Sumpio BJ, Dillon BJ, Lee AI, Blume P, Sumpio BE, Mena-Hurtado C. Acute Limb Ischemia in an 8-Year-Old Patient: A Case Report. Annals Of Vascular Surgery 2018, 51: 327.e1-327.e8. PMID: 29655809, DOI: 10.1016/j.avsg.2018.02.012.
- Erben Y, Jean RA, Protack CD, Chiu AS, Liu S, Sumpio BJ, Miller SM, Sumpio BE. Improved mortality in treatment of patients with endovascular interventions for chronic mesenteric ischemia. Journal Of Vascular Surgery 2018, 67: 1805-1812. PMID: 29395425, DOI: 10.1016/j.jvs.2017.10.071.
- Erben Y, Mena-Hurtado CI, Miller SM, Jean RA, Sumpio BJ, Velasquez CA, Mojibian H, Aruny J, Dardik A, Sumpio BE. Increased mortality in octogenarians treated for lifestyle limiting claudication. Catheterization And Cardiovascular Interventions : Official Journal Of The Society For Cardiac Angiography & Interventions 2018, 91: 1331-1338. PMID: 29405592, DOI: 10.1002/ccd.27523.
- Ochoa Chaar CI, Aurshina A, Zhang Y, Wang F, Cardella J, Orion K, Sumpio B, Sarac T. The effect of commercial insurance policies on outcomes of venous ablation. Journal Of Vascular Surgery. Venous And Lymphatic Disorders 2018, 6: 331-337.e1. PMID: 29661363, DOI: 10.1016/j.jvsv.2017.11.013.
- Alvelo JL, Papademetris X, Mena-Hurtado C, Jeon S, Sumpio BE, Sinusas AJ, Stacy MR. Radiotracer Imaging Allows for Noninvasive Detection and Quantification of Abnormalities in Angiosome Foot Perfusion in Diabetic Patients With Critical Limb Ischemia and Nonhealing Wounds. Circulation. Cardiovascular Imaging 2018, 11: e006932. PMID: 29748311, PMCID: PMC5951395, DOI: 10.1161/CIRCIMAGING.117.006932.
- Henry HT, Szolomayer LK, Sumpio BE, Sutton KM. Popliteal Artery Entrapment Syndrome: Bilateral Lower Extremity Involvement. Orthopedics 2018, 41: e295-e298. PMID: 28934539, DOI: 10.3928/01477447-20170918-10.
- Protack C, Wengerter B, Jean RA, Liu S, Mojibian H, Sumpio B, Dardik A, Maung AA, Erben Y. Overutilization of Cross-Sectional Imaging in the Lower Extremity Trauma Setting. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2018, 27: 23-28. PMID: 29483762, PMCID: PMC5825222, DOI: 10.1055/s-0037-1612622.
- Gupta S, Andersen C, Black J, de Leon J, Fife C, Lantis Ii JC, Niezgoda J, Snyder R, Sumpio B, Tettelbach W, Treadwell T, Weir D, Silverman RP. Management of Chronic Wounds: Diagnosis, Preparation, Treatment, and Follow-up. Wounds : A Compendium Of Clinical Research And Practice 2017, 29: S19-S36. PMID: 28862980.
- Ochoa Chaar CI, Shebl F, Sumpio B, Dardik A, Indes J, Sarac T. Distal embolization during lower extremity endovascular interventions. Journal Of Vascular Surgery 2017, 66: 143-150. PMID: 28366300, DOI: 10.1016/j.jvs.2017.01.032.
- Shalaby SY, Chitragari G, Sumpio BJ, Sumpio BE. Shear Stress Induces Change in Extracellular Signal-Regulated Kinase 5 Levels with Sustained Activation under Disturbed and Continuous Laminar Flow. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2017, 26: 109-115. PMID: 28566937, PMCID: PMC5446257, DOI: 10.1055/s-0037-1599057.
- Haser GC, Sumpio B. Systemic and cell-specific mechanisms of vasculopathy induced by human immunodeficiency virus and highly active antiretroviral therapy. Journal Of Vascular Surgery 2017, 65: 849-859. PMID: 26994951, DOI: 10.1016/j.jvs.2016.01.036.
- Chin JA, Skrip L, Sumpio BE, Cardella JA, Indes JE, Sarac TP, Dardik A, Ochoa Chaar CI. Percutaneous endovascular aneurysm repair in morbidly obese patients. Journal Of Vascular Surgery 2017, 65: 643-650.e1. PMID: 28034584, DOI: 10.1016/j.jvs.2016.06.115.
- Gates L, Chin JA, Bonde PN, Ochoa Chaar CI, Sumpio BE, Sarac TP. Explantation of infected aortic aneurysm and endograft with ascending aorta to mesenteric bypass for mesenteric ischemia. Journal Of Vascular Surgery 2017, 65: 219-223. PMID: 27183855, DOI: 10.1016/j.jvs.2016.03.411.
- Sumpio BJ, Citoni G, Chin JA, Sumpio BE. Use of hyperspectral imaging to assess endothelial dysfunction in peripheral arterial disease. Journal Of Vascular Surgery 2016, 64: 1066-73. PMID: 27266597, DOI: 10.1016/j.jvs.2016.03.463.
- Hogendoorn W, Moll FL, Sumpio BE, Hunink MG. Clinical Decision Analysis and Markov Modeling for Surgeons: An Introductory Overview. Annals Of Surgery 2016, 264: 268-74. PMID: 26756750, DOI: 10.1097/SLA.0000000000001569.
- Huynh N, Gates L, Scoutt L, Sumpio B, Sarac T, Ochoa Chaar CI. May-Thurner syndrome and iliac arteriovenous fistula in an elderly woman. Journal Of Vascular Surgery Cases And Innovative Techniques 2016, 2: 46-49. PMID: 31193380, PMCID: PMC6526307, DOI: 10.1016/j.jvsc.2016.02.001.
- Rajaee S, Hurtado CM, Sumpio B. Drug-Eluting Stents: New Tools for the Armamentarium Against Peripheral Arterial Disease. Surgical Technology International 2015, 27: 200-7. PMID: 26680398.
- Chitragari G, Schlosser FJ, Ochoa Chaar CI, Sumpio BE. Consequences of hypogastric artery ligation, embolization, or coverage. Journal Of Vascular Surgery 2015, 62: 1340-7.e1. PMID: 26386508, DOI: 10.1016/j.jvs.2015.08.053.
- Hogendoorn W, Lavida A, Hunink MG, Moll FL, Geroulakos G, Muhs BE, Sumpio BE. Cost-effectiveness of endovascular repair, open repair, and conservative management of splenic artery aneurysms. Journal Of Vascular Surgery 2015, 61: 1432-40. PMID: 25827968, DOI: 10.1016/j.jvs.2014.12.064.
- Sherif S, Sumpio BE. Economic development and diabetes prevalence in MENA countries: Egypt and Saudi Arabia comparison. World Journal Of Diabetes 2015, 6: 304-11. PMID: 25789111, PMCID: PMC4360423, DOI: 10.4239/wjd.v6.i2.304.
- Sumpio BJ, Chitragari G, Moriguchi T, Shalaby S, Pappas-Brown V, Khan AM, Sekaran SD, Sumpio BE, Grab DJ. African Trypanosome-Induced Blood-Brain Barrier Dysfunction under Shear Stress May Not Require ERK Activation. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2015, 24: 41-6. PMID: 27053915, PMCID: PMC4813428, DOI: 10.1055/s-0034-1370890.
- Moriguchi T, Sumpio BE. PECAM-1 phosphorylation and tissue factor expression in HUVECs exposed to uniform and disturbed pulsatile flow and chemical stimuli. Journal Of Vascular Surgery 2015, 61: 481-8. PMID: 24342062, DOI: 10.1016/j.jvs.2013.09.059.
- Young CJ, Dardik A, Sumpio B, Indes J, Muhs B, Ochoa Chaar CI. Venous ulcer: late complication of a traumatic arteriovenous fistula. Annals Of Vascular Surgery 2015, 29: 836.e1-3. PMID: 25725283, DOI: 10.1016/j.avsg.2014.11.020.
- Schulte W, Rodriguez-Davalos M, Lujic M, Schlosser F, Sumpio B. Operative Management of Hilar Renal Artery Aneurysm in a Pregnant Patient. Annals Of Vascular Diseases 2015, 8: 242-5. PMID: 26421074, PMCID: PMC4575337, DOI: 10.3400/avd.cr.15-00026.
- Hogendoorn W, Lavida A, Hunink MG, Moll FL, Geroulakos G, Muhs BE, Sumpio BE. Open repair, endovascular repair, and conservative management of true splenic artery aneurysms. Journal Of Vascular Surgery 2014, 60: 1667-76.e1. PMID: 25264364, DOI: 10.1016/j.jvs.2014.08.067.
- Chin JA, Sumpio BE. New advances in limb salvage. Surgical Technology International 2014, 25: 212-6. PMID: 25433346.
- Chitragari G, Shalaby SY, Sumpio BJ, Sumpio BE. Effect of pulsatile and continuous flow on yes-associated protein. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2014, 23: 183-6. PMID: 25317030, PMCID: PMC4169103, DOI: 10.1055/s-0034-1376865.
- Shalaby S, Chitragari G, Sumpio BJ, Sumpio BE. Characterization of extracellular signal-regulated kinase 5 levels in human umbilical vein endothelial cells exposed to disturbed and uniform flow. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2014, 23: 187-92. PMID: 25317031, PMCID: PMC4169104, DOI: 10.1055/s-0034-1378136.
- Hogendoorn W, Hunink MG, Schlösser FJ, Moll FL, Muhs BE, Sumpio BE. A comparison of open and endovascular revascularization for chronic mesenteric ischemia in a clinical decision model. Journal Of Vascular Surgery 2014, 60: 715-25.e2. PMID: 24721175, DOI: 10.1016/j.jvs.2014.03.009.
- Hogendoorn W, Hunink MG, Schlösser FJ, Moll FL, Sumpio BE, Muhs BE. Endovascular vs. open repair of complicated acute type B aortic dissections. Journal Of Endovascular Therapy : An Official Journal Of The International Society Of Endovascular Specialists 2014, 21: 503-14. PMID: 25101577, DOI: 10.1583/14-4716R.1.
- Hogendoorn W, Hunink MG, Schlösser FJ, Moll FL, Sumpio BE, Muhs BE. A clinical decision model for selecting the most appropriate therapy for uncomplicated chronic dissections of the descending aorta. Journal Of Vascular Surgery 2014, 60: 20-30. PMID: 24613191, DOI: 10.1016/j.jvs.2014.01.054.
- Ziegler KR, Cruz J, Muhs BE, Indes JE, Sumpio BE, Chaar CI. Iatrogenic profunda femoris stenosis after superficial femoral artery stenting. The American Surgeon 2014, 80: E155-6. PMID: 24887776.
- Hogendoorn W, Schlösser FJ, Aruny JE, Indes JE, Sumpio BE, Muhs BE. Successful treatment of a proximal type I endoleak with HeliFX EndoAnchors. Annals Of Vascular Surgery 2014, 28: 737.e13-7. PMID: 24184495, DOI: 10.1016/j.avsg.2013.07.028.
- Hogendoorn W, Schlösser FJ, Moll FL, Muhs BE, Hunink MG, Sumpio BE. Decision analysis model of open repair versus endovascular treatment in patients with asymptomatic popliteal artery aneurysms. Journal Of Vascular Surgery 2014, 59: 651-62. PMID: 24246533, DOI: 10.1016/j.jvs.2013.09.026.
- Benitez E, Sumpio BJ, Chin J, Sumpio BE. Contemporary assessment of foot perfusion in patients with critical limb ischemia. Seminars In Vascular Surgery 2014, 27: 3-15. PMID: 25812754, DOI: 10.1053/j.semvascsurg.2014.12.001.
- Chitragari G, Mahler DB, Sumpio BJ, Blume PA, Sumpio BE. Prosthetic options available for the diabetic lower limb amputee. Clinics In Podiatric Medicine And Surgery 2014, 31: 173-85. PMID: 24296024, DOI: 10.1016/j.cpm.2013.09.008.
- Blume PA, Sumpio B, Schmidt B, Donegan R. Charcot neuroarthropathy of the foot and ankle: diagnosis and management strategies. Clinics In Podiatric Medicine And Surgery 2014, 31: 151-72. PMID: 24296023, DOI: 10.1016/j.cpm.2013.09.007.
- Shalaby SY, Blume P, Sumpio BE. New modalities in the chronic ischemic diabetic foot management. Clinics In Podiatric Medicine And Surgery 2014, 31: 27-42. PMID: 24296016, DOI: 10.1016/j.cpm.2013.09.009.
- Chin JA, Sumpio BE. Diabetes mellitus and peripheral vascular disease: diagnosis and management. Clinics In Podiatric Medicine And Surgery 2014, 31: 11-26. PMID: 24296015, DOI: 10.1016/j.cpm.2013.09.001.
- Donegan R, Sumpio B, Blume PA. Charcot foot and ankle with osteomyelitis. Diabetic Foot & Ankle 2013, 4 PMID: 24098835, PMCID: PMC3789286, DOI: 10.3402/dfa.v4i0.21361.
- Brölmann FE, Eskes AM, Sumpio BE, Mayer DO, Moore Z, Agren MS, Hermans M, Cutting K, Legemate DA, Vermeulen H, Ubbink DT. Fundamentals of randomized clinical trials in wound care: reporting standards. Wound Repair And Regeneration : Official Publication Of The Wound Healing Society [and] The European Tissue Repair Society 2013, 21: 641-7. PMID: 23937172, DOI: 10.1111/wrr.12087.
- Sumpio BE, Forsythe RO, Ziegler KR, van Baal JG, Lepantalo MJ, Hinchliffe RJ. Clinical implications of the angiosome model in peripheral vascular disease. Journal Of Vascular Surgery 2013, 58: 814-26. PMID: 23972249, DOI: 10.1016/j.jvs.2013.06.056.
- Hogendoorn W, Schlösser FJ, Moll FL, Sumpio BE, Muhs BE. Thoracic endovascular aortic repair with the chimney graft technique. Journal Of Vascular Surgery 2013, 58: 502-11. PMID: 23697513, DOI: 10.1016/j.jvs.2013.03.043.
- Sumpio B, Shine SR, Mahler D, Sumpio BE. A comparison of immediate postoperative rigid and soft dressings for below-knee amputations. Annals Of Vascular Surgery 2013, 27: 774-80. PMID: 23880455, DOI: 10.1016/j.avsg.2013.03.007.
- Sumpio BE. Application of Porter’s Five Forces Model and generic strategies for vascular surgery: should be stuck in the middle? Vascular 2013, 21: 149-56. PMID: 23518839, DOI: 10.1177/1708538112473707.
- Hogendoorn W, Schlösser FJ, Sumpio BE. A Giant Superior Mesenteric Artery Aneurysm Mimicking an Abdominal Aortic Aneurysm. Aorta (Stamford, Conn.) 2013, 1: 52-6. PMID: 26798672, PMCID: PMC4682698, DOI: 10.12945/j.aorta.2013.12.010.
- Fonseca AL, Cleary MA, Cholewczynski W, Sumpio BE, Atweh NA. Omental vein catheter thrombolysis for acute porto-mesenteric vein thrombosis. Annals Of Vascular Surgery 2013, 27: 497.e1-4. PMID: 23566871, DOI: 10.1016/j.avsg.2012.09.009.
- Sumpio BE. Too small to fail: the prisoner's dilemma. Journal Of Vascular Surgery 2013, 57: 1415-21. PMID: 23601596, DOI: 10.1016/j.jvs.2013.01.005.
- Brown HA, Aruny JE, Elefteriades JA, Sumpio BE. Subclavian aneurysm presenting with massive hemoptysis: a case report and review of the literature. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2013, 22: 69-74. PMID: 24436588, PMCID: PMC3699228, DOI: 10.1055/s-0033-1333862.
- Davis B, Moriguchi T, Sumpio B. Optimizing cardiovascular benefits of exercise: a review of rodent models. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2013, 22: 13-22. PMID: 24436579, PMCID: PMC3699221, DOI: 10.1055/s-0033-1333867.
- Cordova AC, Sumpio BE. [Not Available]. Annals Of Vascular Diseases 2013, 6: 687-93. PMID: 24386016, PMCID: PMC3866356, DOI: 10.3400/avd.ra.13-00045.
- Eskes AM, Brölmann FE, Sumpio BE, Mayer D, Moore Z, Agren MS, Hermans M, Cutting K, Legemate DA, Ubbink DT, Vermeulen H. Fundamentals of randomized clinical trials in wound care: design and conduct. Wound Repair And Regeneration : Official Publication Of The Wound Healing Society [and] The European Tissue Repair Society 2012, 20: 449-55. PMID: 22642397, DOI: 10.1111/j.1524-475X.2012.00799.x.
- Abe R, Beckett J, Abe R, Nixon A, Rochier A, Yamashita N, Sumpio B. Olive Oil Polyphenols Differentially Inhibit Smooth Muscle Cell Proliferation through a G1/S Cell Cycle Block Regulated by ERK1/2. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2012, 21: 69-76. PMID: 23730132, PMCID: PMC3444010, DOI: 10.1055/s-0032-1315630.
- Basco MT, Schlösser FJ, Muhs BE, Indes JE, Blume PA, Key JJ, Aruny JE, Sumpio BE. Lower extremity limb salvage with cryoplasty: a single-center cohort study. Vascular 2012, 20: 36-41. PMID: 22328618, DOI: 10.1258/vasc.2011.oa0309.
- Sumpio BE. Contemporary evaluation and management of the diabetic foot. Scientifica 2012, 2012: 435487. PMID: 24278695, PMCID: PMC3820495, DOI: 10.6064/2012/435487.
- Cordova AC, Sumpio BJ, Sumpio BE. Perfecting the plate: adding cardioprotective compounds to the diet. Journal Of The American College Of Surgeons 2012, 214: 97-114. PMID: 22055584, DOI: 10.1016/j.jamcollsurg.2011.09.023.
- Ikem I, Sumpio BE. Cardiovascular disease: the new epidemic in sub-Saharan Africa. Vascular 2011, 19: 301-7. PMID: 21940758, DOI: 10.1258/vasc.2011.ra0049.
- Sumpio B, Thakor P, Mahler D, Blume P. Negative pressure wound therapy as postoperative dressing in below knee amputation stump closure of patients with chronic venous insufficiency. Wounds : A Compendium Of Clinical Research And Practice 2011, 23: 301-8. PMID: 25881107.
- Yamashita N, Abe R, Nixon AM, Rochier AL, Madri JA, Sumpio BE. Cyclic strain delays the expression of tissue factor induced by thrombin in human umbilical vein endothelial cells. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2011, 20: 157-66. PMID: 22942631, PMCID: PMC3331651, DOI: 10.1055/s-0031-1284475.
- Abe R, Yamashita N, Rochier A, Nixon A, Abe R, Madri JA, Sumpio BE. Varying effects of hemodynamic forces on tissue factor RNA expression in human endothelial cells. The Journal Of Surgical Research 2011, 170: 150-6. PMID: 21592524, DOI: 10.1016/j.jss.2011.04.002.
- Rochier A, Nixon A, Yamashita N, Abe R, Abe R, Madri JA, Sumpio BE. Laminar shear, but not orbital shear, has a synergistic effect with thrombin stimulation on tissue factor expression in human umbilical vein endothelial cells. Journal Of Vascular Surgery 2011, 54: 480-8. PMID: 21367569, DOI: 10.1016/j.jvs.2011.01.002.
- Esemuede N, Lee T, Maier KG, Sumpio BE, Gahtan V. Lovastatin inhibits thrombospondin-1-induced smooth muscle cell chemotaxis. The Journal Of Surgical Research 2011, 168: 149-54. PMID: 20338582, DOI: 10.1016/j.jss.2009.11.728.
- Schlösser FJ, Aruny JE, Freiburg CB, Mojibian HR, Sumpio BE, Muhs BE. The chimney procedure is an emergently available endovascular solution for visceral aortic aneurysm rupture. Journal Of Vascular Surgery 2011, 53: 1386-90. PMID: 21276684, DOI: 10.1016/j.jvs.2010.11.097.
- Abe R, Yamashita N, Rochier A, Abe R, Nixon A, Madri JA, Sumpio BE. Pulsatile to-fro flow induces greater and sustained expression of tissue factor RNA in HUVEC than unidirectional laminar flow. American Journal Of Physiology. Heart And Circulatory Physiology 2011, 300: H1345-51. PMID: 21257914, PMCID: PMC3075035, DOI: 10.1152/ajpheart.01197.2010.
- Feng Y, Schlösser FJ, Sumpio BE. The Semmes Weinstein monofilament examination is a significant predictor of the risk of foot ulceration and amputation in patients with diabetes mellitus. Journal Of Vascular Surgery 2011, 53: 220-226.e1-5. PMID: 20692793, DOI: 10.1016/j.jvs.2010.06.100.
- Cordova AC, Bowen FW, Price LA, Dudrick SJ, Sumpio BE. Traumatic innominate artery pseudoaneurysm in the setting of a bovine arch. Annals Of Vascular Diseases 2011, 4: 252-5. PMID: 23555463, PMCID: PMC3595805, DOI: 10.3400/avd.cr.11.00028.
- Willis AI, Sadowitz B, Fuse S, Maier KG, Lee TS, Wang XJ, Tuszynski GP, Sumpio BE, Gahtan V. Thrombospondin 1, fibronectin, and vitronectin are differentially dependent upon RAS, ERK1/2, and p38 for induction of vascular smooth muscle cell chemotaxis. Vascular And Endovascular Surgery 2011, 45: 55-62. PMID: 21193465, DOI: 10.1177/1538574410387677.
- Blume PA, Key JJ, Thakor P, Thakor S, Sumpio B. Retrospective evaluation of clinical outcomes in subjects with split-thickness skin graft: comparing V.A.C.® therapy and conventional therapy in foot and ankle reconstructive surgeries. International Wound Journal 2010, 7: 480-7. PMID: 20825510, PMCID: PMC7951281, DOI: 10.1111/j.1742-481X.2010.00728.x.
- Jonker FH, Schlosser FJ, Geirsson A, Sumpio BE, Moll FL, Muhs BE. Endograft collapse after thoracic endovascular aortic repair. Journal Of Endovascular Therapy : An Official Journal Of The International Society Of Endovascular Specialists 2010, 17: 725-34. PMID: 21142480, DOI: 10.1583/10-3130.1.
- Liapis C, Veith F, Riambau V, Sumpio B, Azuma N, Lee TS, Parakh R, Biasi G. Terms of reference for the Standards of Practice and Training Committee. Vascular 2010, 18: 227-9. PMID: 20643032, DOI: 10.2310/6670.2009.00051.
- Sumpio BE, Armstrong DG, Lavery LA, Andros G. The role of interdisciplinary team approach in the management of the diabetic foot: a joint statement from the Society for Vascular Surgery and the American Podiatric Medical Association. Journal Of The American Podiatric Medical Association 2010, 100: 309-11. PMID: 20660885, DOI: 10.7547/1000309.
- Nixon AM, Gunel M, Sumpio BE. The critical role of hemodynamics in the development of cerebral vascular disease. Journal Of Neurosurgery 2010, 112: 1240-53. PMID: 19943737, DOI: 10.3171/2009.10.JNS09759.
- Basco MT, Yiu WK, Cheng SW, Sumpio BE. The effects of freezing versus supercooling on vascular cells: implications for balloon cryoplasty. Journal Of Vascular And Interventional Radiology : JVIR 2010, 21: 910-5. PMID: 20417120, PMCID: PMC2878641, DOI: 10.1016/j.jvir.2010.02.016.
- Sumpio BE, Armstrong DG, Lavery LA, Andros G. The role of interdisciplinary team approach in the management of the diabetic foot: a joint statement from the Society for Vascular Surgery and the American Podiatric Medical Association. Journal Of Vascular Surgery 2010, 51: 1504-6. PMID: 20488327, DOI: 10.1016/j.jvs.2010.04.010.
- Jonker FH, Schlosser FJ, Indes JE, Sumpio BE, Botta DM, Moll FL, Muhs BE. Management of type A aortic dissections: a meta-analysis of the literature. The Annals Of Thoracic Surgery 2010, 89: 2061-6. PMID: 20494094, DOI: 10.1016/j.athoracsur.2009.11.020.
- Jonker FH, Trimarchi S, Verhagen HJ, Moll FL, Sumpio BE, Muhs BE. Meta-analysis of open versus endovascular repair for ruptured descending thoracic aortic aneurysm. Journal Of Vascular Surgery 2010, 51: 1026-32, 1032.e1-1032.e2. PMID: 20347700, DOI: 10.1016/j.jvs.2009.10.103.
- Tan A, Sumpio BE, Lee S, Seifalian AM. The implications of human stem cell differentiation to endothelial cell via fluid shear stress in cardiovascular regenerative medicine: a review. Current Pharmaceutical Design 2010, 16: 3848-61. PMID: 21128890, DOI: 10.2174/138161210794455058.
- Duffy AJ, Panait L, Eisenberg D, Bell RL, Roberts KE, Sumpio B. Management of median arcuate ligament syndrome: a new paradigm. Annals Of Vascular Surgery 2009, 23: 778-84. PMID: 19128929, DOI: 10.1016/j.avsg.2008.11.005.
- Cordova AC, Sumpio BE. Polyphenols are medicine: Is it time to prescribe red wine for our patients? The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2009, 18: 111-7. PMID: 22477510, PMCID: PMC2903024, DOI: 10.1055/s-0031-1278336.
- Feng Y, Schlösser FJ, Sumpio BE. The Semmes Weinstein monofilament examination as a screening tool for diabetic peripheral neuropathy. Journal Of Vascular Surgery 2009, 50: 675-82, 682.e1. PMID: 19595541, DOI: 10.1016/j.jvs.2009.05.017.
- Rochier AL, Sumpio BE. Variant of popliteal entrapment syndrome involving the lateral head of the gastrocnemius muscle: a case report. Annals Of Vascular Surgery 2009, 23: 535.e5-9. PMID: 19467831, DOI: 10.1016/j.avsg.2009.02.003.
- Nishimura K, Blume P, Ohgi S, Sumpio BE. The effect of different frequencies of stretch on human dermal keratinocyte proliferation and survival. The Journal Of Surgical Research 2009, 155: 125-31. PMID: 19059608, DOI: 10.1016/j.jss.2008.07.029.
- Orgill DP, Manders EK, Sumpio BE, Lee RC, Attinger CE, Gurtner GC, Ehrlich HP. The mechanisms of action of vacuum assisted closure: more to learn. Surgery 2009, 146: 40-51. PMID: 19541009, DOI: 10.1016/j.surg.2009.02.002.
- Wen H, Blume PA, Sumpio BE. Role of integrins and focal adhesion kinase in the orientation of dermal fibroblasts exposed to cyclic strain. International Wound Journal 2009, 6: 149-58. PMID: 19432665, PMCID: PMC7951581, DOI: 10.1111/j.1742-481X.2009.00591.x.
- Longo WE, Sumpio B, Duffy A, Seashore J, Udelsman R. Early specialization in surgery: the new frontier. The Yale Journal Of Biology And Medicine 2008, 81: 187-91. PMID: 19099049, PMCID: PMC2605312.
- Huang CL, Sumpio BE. Olive oil, the mediterranean diet, and cardiovascular health. Journal Of The American College Of Surgeons 2008, 207: 407-16. PMID: 18722947, DOI: 10.1016/j.jamcollsurg.2008.02.018.
- Sumpio BE, Allie DE, Horvath KA, Marston WA, Meites HL, Mills JL, Orgill DP, Salazar JD, Song DH, Toursarkissian B. Role of negative pressure wound therapy in treating peripheral vascular graft infections. Vascular 2008, 16: 194-200. PMID: 18845099, DOI: 10.2310/6670.2008.00041.
- Fuse S, Esemuede N, Yamaguchi M, Maier KG, Nesselroth SM, Sumpio BE, Gahtan V. The role of G proteins in thromospondin-1-induced vascular smooth muscle cell migration. Surgery 2008, 144: 86-92. PMID: 18571589, DOI: 10.1016/j.surg.2008.03.028.
- Bazan HA, Pradhan S, Westvik TS, Sumpio BE, Gusberg RJ, Dardik A. Urgent carotid endarterectomy is safe in patients with few comorbid medical conditions. Annals Of Vascular Surgery 2008, 22: 505-12. PMID: 18462920, DOI: 10.1016/j.avsg.2007.12.019.
- Wang XJ, Maier K, Fuse S, Willis AI, Olson E, Nesselroth S, Sumpio BE, Gahtan V. Thrombospondin-1-induced migration is functionally dependent upon focal adhesion kinase. Vascular And Endovascular Surgery 2008, 42: 256-62. PMID: 18319354, DOI: 10.1177/1538574408314440.
- Yiu WK, Cheng SW, Sumpio BE. Synergistic effect of cool/thaw cycles on vascular cells in an in vitro model of cryoplasty. Journal Of Vascular And Interventional Radiology : JVIR 2008, 19: 925-30. PMID: 18503909, DOI: 10.1016/j.jvir.2008.02.007.
- Spate K, Aziz F, Sumpio BE. The use of retrievable inferior vena cava filters in the trauma population. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2008, 17: 23-6. PMID: 22477367, PMCID: PMC2728370, DOI: 10.1055/s-0031-1278275.
- Tang PC, Ravji K, Key JJ, Mahler DB, Blume PA, Sumpio B. Let them walk! Current prosthesis options for leg and foot amputees. Journal Of The American College Of Surgeons 2008, 206: 548-60. PMID: 18308228, DOI: 10.1016/j.jamcollsurg.2007.10.007.
- Kim JI, Cordova AC, Hirayama Y, Madri JA, Sumpio BE. Differential effects of shear stress and cyclic strain on Sp1 phosphorylation by protein kinase Czeta modulates membrane type 1-matrix metalloproteinase in endothelial cells. Endothelium : Journal Of Endothelial Cell Research 2008, 15: 33-42. PMID: 18568943, PMCID: PMC2644408, DOI: 10.1080/10623320802092260.
- Bazan HA, Reiner E, Sumpio B. Management of bilateral phlegmasia cerulea dolens in a patient with subacute splenic laceration. Annals Of Vascular Diseases 2008, 1: 45-8. PMID: 23555338, PMCID: PMC3610218, DOI: 10.3400/avd.AVDcr07002.
- Hirayama Y, Sumpio BE. Role of ligand-specific integrins in endothelial cell alignment and elongation induced by cyclic strain. Endothelium : Journal Of Endothelial Cell Research 2007, 14: 275-83. PMID: 18080865, DOI: 10.1080/10623320701746248.
- Pressley ZM, Foster JK, Kolm P, Zhao L, Warren F, Weintraub W, Sumpio BE, Chen SC. Digital image analysis: a reliable tool in the quantitative evaluation of cutaneous lesions and beyond. Archives Of Dermatology 2007, 143: 1331-3. PMID: 17938354, DOI: 10.1001/archderm.143.10.1331.
- Pradhan S, Elefteriades JA, Sumpio BE. Utility of the aortic fenestration technique in the management of acute aortic dissections. Annals Of Thoracic And Cardiovascular Surgery : Official Journal Of The Association Of Thoracic And Cardiovascular Surgeons Of Asia 2007, 13: 296-300. PMID: 17954985.
- Aziz F, Spate K, Wong J, Aruny J, Sumpio B. Changing patterns in the use of inferior vena cava filters: review of a single center experience. Journal Of The American College Of Surgeons 2007, 205: 564-9. PMID: 17903730, DOI: 10.1016/j.jamcollsurg.2007.05.026.
- Nishimura K, Blume P, Ohgi S, Sumpio BE. Effect of different frequencies of tensile strain on human dermal fibroblast proliferation and survival. Wound Repair And Regeneration : Official Publication Of The Wound Healing Society [and] The European Tissue Repair Society 2007, 15: 646-56. PMID: 17971010, DOI: 10.1111/j.1524-475X.2007.00295.x.
- Direct comparison of endothelial cell and smooth muscle cell response to supercooling and rewarming.Yiu WK, Cheng SW, Sumpio BE. Direct comparison of endothelial cell and smooth muscle cell response to supercooling and rewarming. Journal Of Vascular Surgery 2007, 46: 557-564. PMID: 17826245, DOI: 10.1016/j.jvs.2007.04.072.
- Kadohama T, Nishimura K, Hoshino Y, Sasajima T, Sumpio BE. Effects of different types of fluid shear stress on endothelial cell proliferation and survival. Journal Of Cellular Physiology 2007, 212: 244-51. PMID: 17323381, DOI: 10.1002/jcp.21024.
- Gumbs AA, Hanan S, Yue JJ, Shah RV, Sumpio B. Revision open anterior approaches for spine procedures. The Spine Journal : Official Journal Of The North American Spine Society 2007, 7: 280-5. PMID: 17482110, DOI: 10.1016/j.spinee.2006.05.015.
- Blume P, Salonga C, Garbalosa J, Pierre-Paul D, Key J, Gahtan V, Sumpio BE. Predictors for the healing of transmetatarsal amputations: retrospective study of 91 amputations. Vascular 2007, 15: 126-33. PMID: 17573017, DOI: 10.2310/6670.2007.00035.
- Yiu WK, Basco MT, Aruny JE, Cheng SW, Sumpio BE. Cryosurgery: A review. The International Journal Of Angiology : Official Publication Of The International College Of Angiology, Inc 2007, 16: 1-6. PMID: 22477240, PMCID: PMC2732998, DOI: 10.1055/s-0031-1278235.
- Hoshino Y, Nishimura K, Sumpio BE. Phosphatase PTEN is inactivated in bovine aortic endothelial cells exposed to cyclic strain. Journal Of Cellular Biochemistry 2007, 100: 515-26. PMID: 16927376, DOI: 10.1002/jcb.21085.
- Yiu WK, Cheng SW, Sumpio BE. Vascular smooth muscle cell apoptosis induced by "supercooling" and rewarming. Journal Of Vascular And Interventional Radiology : JVIR 2006, 17: 1971-7. PMID: 17185696, DOI: 10.1097/01.RVI.0000244868.65867.FB.
- Fleck T, Gustafsson R, Harding K, Ingemansson R, Lirtzman MD, Meites HL, Moidl R, Price P, Ritchie A, Salazar J, Sjögren J, Song DH, Sumpio BE, Toursarkissian B, Waldenberger F, Wetzel-Roth W. The management of deep sternal wound infections using vacuum assisted closure (V.A.C.) therapy. International Wound Journal 2006, 3: 273-80. PMID: 17199763, PMCID: PMC7951489, DOI: 10.1111/j.1742-481X.2006.00273.x.
- Biswas P, Canosa S, Schoenfeld D, Schoenfeld J, Li P, Cheas LC, Zhang J, Cordova A, Sumpio B, Madri JA. PECAM-1 affects GSK-3beta-mediated beta-catenin phosphorylation and degradation. The American Journal Of Pathology 2006, 169: 314-24. PMID: 16816383, PMCID: PMC1698776, DOI: 10.2353/ajpath.2006.051112.
- Sumpio BE, Cordova AC, Berke-Schlessel DW, Qin F, Chen QH. Green tea, the "Asian paradox," and cardiovascular disease. Journal Of The American College Of Surgeons 2006, 202: 813-25. PMID: 16648021, DOI: 10.1016/j.jamcollsurg.2006.01.018.
- Nishimura K, Li W, Hoshino Y, Kadohama T, Asada H, Ohgi S, Sumpio BE. Role of AKT in cyclic strain-induced endothelial cell proliferation and survival. American Journal Of Physiology. Cell Physiology 2006, 290: C812-21. PMID: 16469863, DOI: 10.1152/ajpcell.00347.2005.
- Weiss JS, Sumpio BE. Review of prevalence and outcome of vascular disease in patients with diabetes mellitus. European Journal Of Vascular And Endovascular Surgery : The Official Journal Of The European Society For Vascular Surgery 2006, 31: 143-50. PMID: 16203161, DOI: 10.1016/j.ejvs.2005.08.015.
- Ueno H, Pradhan S, Schlessel D, Hirasawa H, Sumpio BE. Nicotine enhances human vascular endothelial cell expression of ICAM-1 and VCAM-1 via protein kinase C, p38 mitogen-activated protein kinase, NF-kappaB, and AP-1. Cardiovascular Toxicology 2006, 6: 39-50. PMID: 16845181, DOI: 10.1385/ct:6:1:39.
- Kadohama T, Akasaka N, Nishimura K, Hoshino Y, Sasajima T, Sumpio BE. p38 Mitogen-activated protein kinase activation in endothelial cell is implicated in cell alignment and elongation induced by fluid shear stress. Endothelium : Journal Of Endothelial Cell Research 2006, 13: 43-50. PMID: 16885066, DOI: 10.1080/10623320600660219.
- Poussier B, Cordova AC, Becquemin JP, Sumpio BE. Resveratrol inhibits vascular smooth muscle cell proliferation and induces apoptosis. Journal Of Vascular Surgery 2005, 42: 1190-7. PMID: 16376213, DOI: 10.1016/j.jvs.2005.08.014.
- Liu SQ, Alkema PK, Tieché C, Tefft BJ, Liu DZ, Li YC, Sumpio BE, Caprini JA, Paniagua M. Negative regulation of monocyte adhesion to arterial elastic laminae by signal regulatory protein alpha and Src homology 2 domain-containing protein-tyrosine phosphatase-1. The Journal Of Biological Chemistry 2005, 280: 39294-301. PMID: 16159885, DOI: 10.1074/jbc.M503866200.
- Kudo FA, Warycha B, Juran PJ, Asada H, Teso D, Aziz F, Frattini J, Sumpio BE, Nishibe T, Cha C, Dardik A. Differential responsiveness of early- and late-passage endothelial cells to shear stress. American Journal Of Surgery 2005, 190: 763-9. PMID: 16226955, DOI: 10.1016/j.amjsurg.2005.07.017.
- Asada H, Paszkowiak J, Teso D, Alvi K, Thorisson A, Frattini JC, Kudo FA, Sumpio BE, Dardik A. Sustained orbital shear stress stimulates smooth muscle cell proliferation via the extracellular signal-regulated protein kinase 1/2 pathway. Journal Of Vascular Surgery 2005, 42: 772-80. PMID: 16242567, DOI: 10.1016/j.jvs.2005.05.046.
- Sumpio BE, Aruny J. Commentary. Cilostazol inhibits leukocyte integrin Mac-1, leading to a potential reduction in restenosis after coronary stent implantation. Perspectives In Vascular Surgery And Endovascular Therapy 2005, 17: 265-7. PMID: 16273169, DOI: 10.1177/153100350501700317.
- Kakisis JD, Pradhan S, Cordova A, Liapis CD, Sumpio BE. The role of STAT-3 in the mediation of smooth muscle cell response to cyclic strain. The International Journal Of Biochemistry & Cell Biology 2005, 37: 1396-406. PMID: 15833272, DOI: 10.1016/j.biocel.2005.01.009.
- Dardik A, Chen L, Frattini J, Asada H, Aziz F, Kudo FA, Sumpio BE. Differential effects of orbital and laminar shear stress on endothelial cells. Journal Of Vascular Surgery 2005, 41: 869-80. PMID: 15886673, DOI: 10.1016/j.jvs.2005.01.020.
- Li W, Sumpio BE. Strain-induced vascular endothelial cell proliferation requires PI3K-dependent mTOR-4E-BP1 signal pathway. American Journal Of Physiology. Heart And Circulatory Physiology 2005, 288: H1591-7. PMID: 15591103, DOI: 10.1152/ajpheart.00382.2004.
- Gumbs AA, Shah RV, Yue JJ, Sumpio B. The open anterior paramedian retroperitoneal approach for spine procedures. Archives Of Surgery (Chicago, Ill. : 1960) 2005, 140: 339-43. PMID: 15837883, DOI: 10.1001/archsurg.140.4.339.
- Sumpio BE, Yun S, Cordova AC, Haga M, Zhang J, Koh Y, Madri JA. MAPKs (ERK1/2, p38) and AKT can be phosphorylated by shear stress independently of platelet endothelial cell adhesion molecule-1 (CD31) in vascular endothelial cells. The Journal Of Biological Chemistry 2005, 280: 11185-91. PMID: 15668248, DOI: 10.1074/jbc.M414631200.
- Akasaka K, Akasaka N, Di Luozzo G, Sasajima T, Sumpio BE. Homocysteine promotes p38-dependent chemotaxis in bovine aortic smooth muscle cells. Journal Of Vascular Surgery 2005, 41: 517-22. PMID: 15838488, DOI: 10.1016/j.jvs.2004.12.043.
- Cordova AC, Jackson LS, Berke-Schlessel DW, Sumpio BE. The cardiovascular protective effect of red wine. Journal Of The American College Of Surgeons 2005, 200: 428-39. PMID: 15737855, DOI: 10.1016/j.jamcollsurg.2004.10.030.
- Kakisis JD, Liapis CD, Breuer C, Sumpio BE. Artificial blood vessel: the Holy Grail of peripheral vascular surgery. Journal Of Vascular Surgery 2005, 41: 349-54. PMID: 15768021, DOI: 10.1016/j.jvs.2004.12.026.
- Di Luozzo G, Pradhan S, Dhadwal AK, Chen A, Ueno H, Sumpio BE. Nicotine induces mitogen-activated protein kinase dependent vascular smooth muscle cell migration. Atherosclerosis 2005, 178: 271-7. PMID: 15694934, DOI: 10.1016/j.atherosclerosis.2004.09.017.
- Dardik A, Yamashita A, Aziz F, Asada H, Sumpio BE. Shear stress-stimulated endothelial cells induce smooth muscle cell chemotaxis via platelet-derived growth factor-BB and interleukin-1alpha. Journal Of Vascular Surgery 2005, 41: 321-31. PMID: 15768016, DOI: 10.1016/j.jvs.2004.11.016.
- Esemuede N, Lee T, Pierre-Paul D, Sumpio BE, Gahtan V. The role of thrombospondin-1 in human disease. The Journal Of Surgical Research 2004, 122: 135-42. PMID: 15522326, DOI: 10.1016/j.jss.2004.05.015.
- Abir F, Barkhordarian S, Sumpio BE. Efficacy of dextran solutions in vascular surgery. Vascular And Endovascular Surgery 2004, 38: 483-91. PMID: 15592628, DOI: 10.1177/153857440403800601.
- Jackson LS, Dudrick SJ, Sumpio BE. John Harvey Kellogg; surgeon, inventor, nutritionist (1852-1943). Journal Of The American College Of Surgeons 2004, 199: 817-21. PMID: 15501124, DOI: 10.1016/j.jamcollsurg.2004.05.279.
- Sumpio BE, Aruny J, Blume PA. The multidisciplinary approach to limb salvage. Acta Chirurgica Belgica 2004, 104: 647-53. PMID: 15663269, DOI: 10.1080/00015458.2004.11679637.
- Pradhan S, Sumpio B. Molecular and biological effects of hemodynamics on vascular cells. Frontiers In Bioscience : A Journal And Virtual Library 2004, 9: 3276-85. PMID: 15353357, DOI: 10.2741/1480.
- Lee T, Sumpio BE. Cell signalling in vascular cells exposed to cyclic strain: the emerging role of protein phosphatases. Biotechnology And Applied Biochemistry 2004, 39: 129-39. PMID: 15032733, DOI: 10.1042/BA20030104.
- Pradhan S, Sumpio BE. Do estrogen effects on blood vessels translate into clinically significant atheroprotection? Journal Of The American College Of Surgeons 2004, 198: 462-74. PMID: 14992749, DOI: 10.1016/j.jamcollsurg.2003.09.026.
- Kakisis JD, Liapis CD, Sumpio BE. Effects of cyclic strain on vascular cells. Endothelium : Journal Of Endothelial Cell Research 2004, 11: 17-28. PMID: 15203876, DOI: 10.1080/10623320490432452.
- Willis AI, Pierre-Paul D, Sumpio BE, Gahtan V. Vascular smooth muscle cell migration: current research and clinical implications. Vascular And Endovascular Surgery 2004, 38: 11-23. PMID: 14760473, DOI: 10.1177/153857440403800102.
- Sumpio BE, Lee T, Blume PA. Vascular evaluation and arterial reconstruction of the diabetic foot. Clinics In Podiatric Medicine And Surgery 2003, 20: 689-708. PMID: 14636033, DOI: 10.1016/S0891-8422(03)00088-0.
- Lee L, Blume PA, Sumpio B. Charcot joint disease in diabetes mellitus. Annals Of Vascular Surgery 2003, 17: 571-80. PMID: 14508661, DOI: 10.1007/s10016-003-0039-5.
- Zhang J, Li W, Sumpio BE, Basson MD. Fibronectin blocks p38 and jnk activation by cyclic strain in Caco-2 cells. Biochemical And Biophysical Research Communications 2003, 306: 746-9. PMID: 12810082, DOI: 10.1016/s0006-291x(03)01044-1.
- Lee T, Esemuede N, Sumpio BE, Gahtan V. Thrombospondin-1 induces matrix metalloproteinase-2 activation in vascular smooth muscle cells. Journal Of Vascular Surgery 2003, 38: 147-54. PMID: 12844104, DOI: 10.1016/s0741-5214(02)75468-2.
- Lee T, Nesselroth SM, Olson ET, Esemuede N, Lawler J, Sumpio BE, Gahtan V. Thrombospondin-1-induced vascular smooth muscle cell chemotaxis: the role of the type 3 repeat and carboxyl terminal domains. Journal Of Cellular Biochemistry 2003, 89: 500-6. PMID: 12761883, DOI: 10.1002/jcb.10524.
- Haga M, Yamashita A, Paszkowiak J, Sumpio BE, Dardik A. Oscillatory shear stress increases smooth muscle cell proliferation and Akt phosphorylation. Journal Of Vascular Surgery 2003, 37: 1277-84. PMID: 12764276, DOI: 10.1016/s0741-5214(03)00329-x.
- Kakisis JD, Abir F, Liapis CD, Sumpio BE. An appraisal of different cardiac risk reduction strategies in vascular surgery patients. European Journal Of Vascular And Endovascular Surgery : The Official Journal Of The European Society For Vascular Surgery 2003, 25: 493-504. PMID: 12787690, DOI: 10.1053/ejvs.2002.1851.
- Li W, Chen Q, Mills I, Sumpio BE. Involvement of S6 kinase and p38 mitogen activated protein kinase pathways in strain-induced alignment and proliferation of bovine aortic smooth muscle cells. Journal Of Cellular Physiology 2003, 195: 202-9. PMID: 12652647, DOI: 10.1002/jcp.10230.
- Zhang J, Li W, Sanders MA, Sumpio BE, Panja A, Basson MD. Regulation of the intestinal epithelial response to cyclic strain by extracellular matrix proteins. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2003, 17: 926-8. PMID: 12626437, DOI: 10.1096/fj.02-0663fje.
- Lee T, Seo JW, Sumpio BE, Kim SJ. Immunobiologic analysis of arterial tissue in Buerger's disease. European Journal Of Vascular And Endovascular Surgery : The Official Journal Of The European Society For Vascular Surgery 2003, 25: 451-7. PMID: 12713785, DOI: 10.1053/ejvs.2002.1869.
- Yamashita A, Hanna AK, Hirata S, Dardik A, Sumpio BE. Antisense basic fibroblast growth factor alters the time course of mitogen-activated protein kinase in arterialized vein graft remodeling. Journal Of Vascular Surgery 2003, 37: 866-73. PMID: 12663990, DOI: 10.1067/mva.2003.130.
- Lee T, Kim SJ, Sumpio BE. Role of PP2A in the regulation of p38 MAPK activation in bovine aortic endothelial cells exposed to cyclic strain. Journal Of Cellular Physiology 2003, 194: 349-55. PMID: 12548554, DOI: 10.1002/jcp.10211.
- Chen Q, Li W, Quan Z, Sumpio BE. Modulation of vascular smooth muscle cell alignment by cyclic strain is dependent on reactive oxygen species and P38 mitogen-activated protein kinase. Journal Of Vascular Surgery 2003, 37: 660-8. PMID: 12618707, DOI: 10.1067/mva.2003.95.
- Abir F, Kakisis I, Sumpio B. Do vascular surgery patients need a cardiology work-up? A review of pre-operative cardiac clearance guidelines in vascular surgery. European Journal Of Vascular And Endovascular Surgery : The Official Journal Of The European Society For Vascular Surgery 2003, 25: 110-7. PMID: 12552470, DOI: 10.1053/ejvs.2002.1797.
- Haga M, Chen A, Gortler D, Dardik A, Sumpio BE. Shear stress and cyclic strain may suppress apoptosis in endothelial cells by different pathways. Endothelium : Journal Of Endothelial Cell Research 2003, 10: 149-57. PMID: 13129818, DOI: 10.1080/10623320390233463.
- Renzulli JF, Borromeo JR, Barkhordarian S, Sumpio BE. Abdominal aortic aneurysm in association with a congenital pelvic horseshoe kidney: sentinel report and technical consideration. Vascular Medicine (London, England) 2003, 8: 197-9. PMID: 14989561, DOI: 10.1191/1358863x03vm495cr.
- Sumpio BE, Riley JT, Dardik A. Cells in focus: endothelial cell. The International Journal Of Biochemistry & Cell Biology 2002, 34: 1508-12. PMID: 12379270, DOI: 10.1016/s1357-2725(02)00075-4.
- Lee DM, Gasparro FP, Wang XJ, Kopec C, DeLeo K, Sumpio BE. Photochemotherapy of vascular cells with 8-methoxypsoralen and visible light: differential effects on endothelial and smooth muscle cells. Photodermatology, Photoimmunology & Photomedicine 2002, 18: 244-52. PMID: 12390666, DOI: 10.1034/j.1600-0781.2002.02770.x.
- Yun S, Dardik A, Haga M, Yamashita A, Yamaguchi S, Koh Y, Madri JA, Sumpio BE. Transcription factor Sp1 phosphorylation induced by shear stress inhibits membrane type 1-matrix metalloproteinase expression in endothelium. The Journal Of Biological Chemistry 2002, 277: 34808-14. PMID: 12093818, DOI: 10.1074/jbc.M205417200.
- Yamaguchi S, Yamaguchi M, Yatsuyanagi E, Yun SS, Nakajima N, Madri JA, Sumpio BE. Cyclic strain stimulates early growth response gene product 1-mediated expression of membrane type 1 matrix metalloproteinase in endothelium. Laboratory Investigation; A Journal Of Technical Methods And Pathology 2002, 82: 949-56. PMID: 12118097, DOI: 10.1097/01.lab.0000020408.77307.e9.
- Araim O, Ballantyne J, Waterhouse AL, Sumpio BE. Inhibition of vascular smooth muscle cell proliferation with red wine and red wine polyphenols. Journal Of Vascular Surgery 2002, 35: 1226-32. PMID: 12042735, DOI: 10.1067/mva.2002.124358.
- Thamilselvan V, Li W, Sumpio BE, Basson MD. Sphingosine-1-phosphate stimulates human Caco-2 intestinal epithelial proliferation via p38 activation and activates ERK by an independent mechanism. In Vitro Cellular & Developmental Biology. Animal 2002, 38: 246-53. PMID: 12197778, DOI: 10.1290/1071-2690(2002)038<0246:SPSHCI>2.0.CO;2.
- Frangos SG, Kilaru S, Sumpio BE, Gahtan V. Effect of gender on outcome following infrainguinal bypass graft surgery: a systematic review. Connecticut Medicine 2002, 66: 137-44. PMID: 11957765.
- Gahtan V, Olson ET, Sumpio BE. Molecular biology: a brief overview. Journal Of Vascular Surgery 2002, 35: 563-8. PMID: 11877707, DOI: 10.1067/mva.2002.120039.
- Blume PA, Paragas LK, Sumpio BE, Attinger CE. Single-stage surgical treatment of noninfected diabetic foot ulcers. Plastic And Reconstructive Surgery 2002, 109: 601-9. PMID: 11818842, DOI: 10.1097/00006534-200202000-00029.
- Throckmorton D, Kurscheid-Reich D, Rosales OR, Rodriguez-Commes J, Lopez R, Sumpio B, Zhong Q, Ding KH, McCarthy R, Barrett PQ, Isales CM. Parathyroid hormone effects on signaling pathways in endothelial cells vary with peptide concentration. Peptides 2002, 23: 79-85. PMID: 11814621, DOI: 10.1016/s0196-9781(01)00582-4.
- Kilaru S, Frangos SG, Chen AH, Gortler D, Dhadwal AK, Araim O, Sumpio BE. Nicotine: a review of its role in atherosclerosis. Journal Of The American College Of Surgeons 2001, 193: 538-46. PMID: 11708512, DOI: 10.1016/s1072-7515(01)01059-6.
- Chen AH, Gortler DS, Kilaru S, Araim O, Frangos SG, Sumpio BE. Cyclic strain activates the pro-survival Akt protein kinase in bovine aortic smooth muscle cells. Surgery 2001, 130: 378-81. PMID: 11490374, DOI: 10.1067/msy.2001.116668.
- Chen AH, Frangos SG, Kilaru S, Sumpio BE. Intermittent pneumatic compression devices -- physiological mechanisms of action. European Journal Of Vascular And Endovascular Surgery : The Official Journal Of The European Society For Vascular Surgery 2001, 21: 383-92. PMID: 11352511, DOI: 10.1053/ejvs.2001.1348.
- Nesselroth SM, Willis AI, Fuse S, Olson ET, Lawler J, Sumpio BE, Gahtan V. The C-terminal domain of thrombospondin-1 induces vascular smooth muscle cell chemotaxis. Journal Of Vascular Surgery 2001, 33: 595-600. PMID: 11241132, DOI: 10.1067/mva.2001.112318.
- Azuma N, Akasaka N, Kito H, Ikeda M, Gahtan V, Sasajima T, Sumpio BE. Role of p38 MAP kinase in endothelial cell alignment induced by fluid shear stress. American Journal Of Physiology. Heart And Circulatory Physiology 2001, 280: H189-97. PMID: 11123233, DOI: 10.1152/ajpheart.2001.280.1.H189.
- Li W, Duzgun A, Sumpio BE, Basson MD. Integrin and FAK-mediated MAPK activation is required for cyclic strain mitogenic effects in Caco-2 cells. American Journal Of Physiology. Gastrointestinal And Liver Physiology 2001, 280: G75-87. PMID: 11123200, DOI: 10.1152/ajpgi.2001.280.1.G75.
- Han O, Takei T, Basson M, Sumpio BE. Translocation of PKC isoforms in bovine aortic smooth muscle cells exposed to strain. Journal Of Cellular Biochemistry 2001, 80: 367-72. PMID: 11135367, DOI: 10.1002/1097-4644(20010301)80:3<367::aid-jcb100>3.0.co;2-2.
- Smith JD, Davies N, Willis AI, Sumpio BE, Zilla P. Cyclic stretch induces the expression of vascular endothelial growth factor in vascular smooth muscle cells. Endothelium : Journal Of Endothelial Cell Research 2001, 8: 41-8. PMID: 11409850, DOI: 10.3109/10623320109063156.
- Frangos SG, Knox R, Yano Y, Chen E, Di Luozzo G, Chen AH, Sumpio BE. The integrin-mediated cyclic strain-induced signaling pathway in vascular endothelial cells. Endothelium : Journal Of Endothelial Cell Research 2001, 8: 1-10. PMID: 11409847, DOI: 10.3109/10623320109063153.
- Kito H, Chen EL, Wang X, Ikeda M, Azuma N, Nakajima N, Gahtan V, Sumpio BE. Role of mitogen-activated protein kinases in pulmonary endothelial cells exposed to cyclic strain. Journal Of Applied Physiology (Bethesda, Md. : 1985) 2000, 89: 2391-400. PMID: 11090594, DOI: 10.1152/jappl.2000.89.6.2391.
- Azuma N, Duzgun SA, Ikeda M, Kito H, Akasaka N, Sasajima T, Sumpio BE. Endothelial cell response to different mechanical forces. Journal Of Vascular Surgery 2000, 32: 789-94. PMID: 11013043, DOI: 10.1067/mva.2000.107989.
- Sumpio BE. Foot ulcers. The New England Journal Of Medicine 2000, 343: 787-93. PMID: 10984568, DOI: 10.1056/NEJM200009143431107.
- Woo DK, Dudrick SJ, Sumpio BE. Homocysteine stimulates MAP kinase in bovine aortic smooth muscle cells. Surgery 2000, 128: 59-66. PMID: 10876187, DOI: 10.1067/msy.2000.106531.
- Murnin M, Kumar A, Li GD, Brown M, Sumpio BE, Basson MD. Effects of glutamine isomers on human (Caco-2) intestinal epithelial proliferation, strain-responsiveness, and differentiation. Journal Of Gastrointestinal Surgery : Official Journal Of The Society For Surgery Of The Alimentary Tract 2000, 4: 435-42. PMID: 11058864, DOI: 10.1016/s1091-255x(00)80025-6.
- Fujioka K, Azuma N, Kito H, Gahtan V, Esato K, Sumpio BE. Role of caveolin in hemodynamic force-mediated endothelial changes. The Journal Of Surgical Research 2000, 92: 7-10. PMID: 10864474, DOI: 10.1006/jsre.2000.5838.
- Willis AI, Fuse S, Wang XJ, Chen E, Tuszynski GP, Sumpio BE, Gahtan V. Inhibition of phosphatidylinositol 3-kinase and protein kinase C attenuates extracellular matrix protein-induced vascular smooth muscle cell chemotaxis. Journal Of Vascular Surgery 2000, 31: 1160-7. PMID: 10842153, DOI: 10.1067/mva.2000.106489.
- Basson MD, Yu CF, Herden-Kirchoff O, Ellermeier M, Sanders MA, Merrell RC, Sumpio BE. Effects of increased ambient pressure on colon cancer cell adhesion. Journal Of Cellular Biochemistry 2000, 78: 47-61. PMID: 10797565, DOI: 10.1002/(sici)1097-4644(20000701)78:1<47::aid-jcb5>3.0.co;2-m.
- Collins KA, Sumpio BE. Vascular assessment. Clinics In Podiatric Medicine And Surgery 2000, 17: 171-91. PMID: 10810651.
- Duzgun SA, Rasque H, Kito H, Azuma N, Li W, Basson MD, Gahtan V, Dudrick SJ, Sumpio BE. Mitogen-activated protein phosphorylation in endothelial cells exposed to hyperosmolar conditions. Journal Of Cellular Biochemistry 2000, 76: 567-71. PMID: 10653976, DOI: 10.1002/(sici)1097-4644(20000315)76:4<567::aid-jcb5>3.0.co;2-w.
- Gahtan V, Wang XJ, Willis AI, Tuszynski GP, Sumpio BE. Thrombospondin-1 regulation of smooth muscle cell chemotaxis is extracellular signal-regulated protein kinases 1/2 dependent. Surgery 1999, 126: 203-7. PMID: 10455885.
- Gahtan V, Wang XJ, Ikeda M, Willis AI, Tuszynski GP, Sumpio BE. Thrombospondin-1 induces activation of focal adhesion kinase in vascular smooth muscle cells. Journal Of Vascular Surgery 1999, 29: 1031-6. PMID: 10359937, DOI: 10.1016/s0741-5214(99)70244-2.
- Ikeda M, Kito H, Sumpio BE. Phosphatidylinositol-3 kinase dependent MAP kinase activation via p21ras in endothelial cells exposed to cyclic strain. Biochemical And Biophysical Research Communications 1999, 257: 668-71. PMID: 10208841, DOI: 10.1006/bbrc.1999.0532.
- Li S, Chen BP, Azuma N, Hu YL, Wu SZ, Sumpio BE, Shyy JY, Chien S. Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress. The Journal Of Clinical Investigation 1999, 103: 1141-50. PMID: 10207166, PMCID: PMC408275, DOI: 10.1172/JCI5367.
- Ikeda M, Takei T, Mills I, Kito H, Sumpio BE. Extracellular signal-regulated kinases 1 and 2 activation in endothelial cells exposed to cyclic strain. The American Journal Of Physiology 1999, 276: H614-22. PMID: 9950863, DOI: 10.1152/ajpheart.1999.276.2.h614.
- Kamal K, Du W, Mills I, Sumpio BE. Antiproliferative effect of elevated glucose in human microvascular endothelial cells. Journal Of Cellular Biochemistry 1998, 71: 491-501. PMID: 9827695, DOI: 10.1002/(sici)1097-4644(19981215)71:4<491::aid-jcb4>3.0.co;2-p.
- Quader MA, Stump LS, Sumpio BE. Low molecular weight heparins: current use and indications. Journal Of The American College Of Surgeons 1998, 187: 641-58. PMID: 9849742, DOI: 10.1016/s1072-7515(98)00255-5.
- Han O, Sumpio BE, Basson MD. Mechanical strain rapidly redistributes tyrosine phosphorylated proteins in human intestinal Caco-2 cells. Biochemical And Biophysical Research Communications 1998, 250: 668-73. PMID: 9784404, DOI: 10.1006/bbrc.1998.9372.
- Han O, Li GD, Sumpio BE, Basson MD. Strain induces Caco-2 intestinal epithelial proliferation and differentiation via PKC and tyrosine kinase signals. The American Journal Of Physiology 1998, 275: G534-41. PMID: 9724266, DOI: 10.1152/ajpgi.1998.275.3.G534.
- Segurola RJ, Mills I, Sumpio BE. Strain-induced dual alignment of L6 rat skeletal muscle cells. In Vitro Cellular & Developmental Biology. Animal 1998, 34: 609-12. PMID: 9769140, DOI: 10.1007/s11626-996-0004-z.
- Gahtan V, Peyman JA, Sumpio BE. Understanding molecular biology. Seminars In Vascular Surgery 1998, 11: 125-33. PMID: 9763112.
- Takei T, Mills I, Arai K, Sumpio BE. Molecular basis for tissue expansion: clinical implications for the surgeon. Plastic And Reconstructive Surgery 1998, 102: 247-58. PMID: 9655439, DOI: 10.1097/00006534-199807000-00044.
- Ikeda M, Takei T, Mills I, Sumpio BE. Calcium-independent activation of extracellular signal-regulated kinases 1 and 2 by cyclic strain. Biochemical And Biophysical Research Communications 1998, 247: 462-5. PMID: 9642151, DOI: 10.1006/bbrc.1998.8811.
- Sawmiller CJ, Powell RJ, Quader M, Dudrick SJ, Sumpio BE. The differential effect of contrast agents on endothelial cell and smooth muscle cell growth in vitro. Journal Of Vascular Surgery 1998, 27: 1128-40. PMID: 9652475, DOI: 10.1016/s0741-5214(98)70015-1.
- Takei T, Kito H, Du W, Mills I, Sumpio BE. Induction of interleukin (IL)-1 alpha and beta gene expression in human keratinocytes exposed to repetitive strain: their role in strain-induced keratinocyte proliferation and morphological change. Journal Of Cellular Biochemistry 1998, 69: 95-103. PMID: 9548558.
- Sawyer MD, van Raaij T, Cross J, Sumpio BE. Novel potentiation of interleukin 1alpha production in endotoxin-stimulated IC-21 cells by ambient pressure augmentation. Archives Of Surgery (Chicago, Ill. : 1960) 1998, 133: 438-41. PMID: 9565126, DOI: 10.1001/archsurg.133.4.438.
- Sumpio BE, Du W, Galagher G, Wang X, Khachigian LM, Collins T, Gimbrone MA, Resnick N. Regulation of PDGF-B in endothelial cells exposed to cyclic strain. Arteriosclerosis, Thrombosis, And Vascular Biology 1998, 18: 349-55. PMID: 9514402, DOI: 10.1161/01.atv.18.3.349.
- Vouyouka AG, Powell RJ, Ricotta J, Chen H, Dudrick DJ, Sawmiller CJ, Dudrick SJ, Sumpio BE. Ambient pulsatile pressure modulates endothelial cell proliferation. Journal Of Molecular And Cellular Cardiology 1998, 30: 609-15. PMID: 9515036, DOI: 10.1006/jmcc.1997.0625.
- Powell RJ, Bhargava J, Basson MD, Sumpio BE. Coculture conditions alter endothelial modulation of TGF-beta 1 activation and smooth muscle growth morphology. The American Journal Of Physiology 1998, 274: H642-9. PMID: 9486269, DOI: 10.1152/ajpheart.1998.274.2.H642.
- Kito H, Yokoyama C, Inoue H, Tanabe T, Nakajima N, Sumpio BE. Cyclooxygenase expression in bovine aortic endothelial cells exposed to cyclic strain. Endothelium : Journal Of Endothelial Cell Research 1998, 6: 107-12. PMID: 9930644, DOI: 10.3109/10623329809072197.
- Schneider SW, Pagel P, Storck J, Yano Y, Sumpio BE, Geibel JP, Oberleithner H. Atomic force microscopy on living cells: aldosterone-induced localized cell swelling. Kidney & Blood Pressure Research 1998, 21: 256-8. PMID: 9762848, DOI: 10.1159/000025869.
- Takei T, Han O, Ikeda M, Male P, Mills I, Sumpio BE. Cyclic strain stimulates isoform-specific PKC activation and translocation in cultured human keratinocytes. Journal Of Cellular Biochemistry 1997, 67: 327-37. PMID: 9361188, DOI: 10.1002/(sici)1097-4644(19971201)67:3<327::aid-jcb5>3.0.co;2-y.
- Schneider SW, Yano Y, Sumpio BE, Jena BP, Geibel JP, Gekle M, Oberleithner H. Rapid aldosterone-induced cell volume increase of endothelial cells measured by the atomic force microscope. Cell Biology International 1997, 21: 759-68. PMID: 9768474, DOI: 10.1006/cbir.1997.0220.
- Sumpio BE, Chang R, Xu WJ, Wang XJ, Du W. Regulation of tPA in endothelial cells exposed to cyclic strain: role of CRE, AP-2, and SSRE binding sites. The American Journal Of Physiology 1997, 273: C1441-8. PMID: 9374627, DOI: 10.1152/ajpcell.1997.273.5.C1441.
- Takei T, Rivas-Gotz C, Delling CA, Koo JT, Mills I, McCarthy TL, Centrella M, Sumpio BE. Effect of strain on human keratinocytes in vitro. Journal Of Cellular Physiology 1997, 173: 64-72. PMID: 9326450, DOI: 10.1002/(SICI)1097-4652(199710)173:1<64::AID-JCP8>3.0.CO;2-H.
- Rosales OR, Isales CM, Barrett PQ, Brophy C, Sumpio BE. Exposure of endothelial cells to cyclic strain induces elevations of cytosolic Ca2+ concentration through mobilization of intracellular and extracellular pools. The Biochemical Journal 1997, 326 ( Pt 2): 385-92. PMID: 9291109, PMCID: PMC1218682, DOI: 10.1042/bj3260385.
- Powell RJ, Roddy SP, Meier GH, Gusberg RJ, Conte MS, Sumpio BE. Effect of renal insufficiency on outcome following infrarenal aortic surgery. American Journal Of Surgery 1997, 174: 126-30. PMID: 9293827, DOI: 10.1016/s0002-9610(97)00069-x.
- Sai Sudhakar CB, al-Hakeem M, Sumpio BE. Venous obstruction of the lower extremity secondary to an enlarged bladder. Connecticut Medicine 1997, 61: 459-60. PMID: 9309893.
- Sudhakar CB, Al-Hakeem M, MacArthur JD, Sumpio BE. Mesenteric ischemia secondary to cocaine abuse: case reports and literature review. The American Journal Of Gastroenterology 1997, 92: 1053-4. PMID: 9177533.
- Chang R, Powell RJ, Sumpio BE. Tissue plasminogen activator-biologic perspective for surgeons. Journal Of The American College Of Surgeons 1997, 184: 529-39. PMID: 9145078.
- Segurola RJ, Oluwole B, Mills I, Yokoyama C, Tanabe T, Kito H, Nakajima N, Sumpio BE. Cyclic strain is a weak inducer of prostacyclin synthase expression in bovine aortic endothelial cells. The Journal Of Surgical Research 1997, 69: 135-8. PMID: 9202659, DOI: 10.1006/jsre.1997.5050.
- Powell RJ, Hydowski J, Frank O, Bhargava J, Sumpio BE. Endothelial cell effect on smooth muscle cell collagen synthesis. The Journal Of Surgical Research 1997, 69: 113-8. PMID: 9202656, DOI: 10.1006/jsre.1997.5045.
- Mills I, Cohen CR, Kamal K, Li G, Shin T, Du W, Sumpio BE. Strain activation of bovine aortic smooth muscle cell proliferation and alignment: study of strain dependency and the role of protein kinase A and C signaling pathways. Journal Of Cellular Physiology 1997, 170: 228-34. PMID: 9066778, DOI: 10.1002/(SICI)1097-4652(199703)170:3<228::AID-JCP2>3.0.CO;2-Q.
- Yano Y, Geibel J, Sumpio BE. Cyclic strain induces reorganization of integrin alpha 5 beta 1 and alpha 2 beta 1 in human umbilical vein endothelial cells. Journal Of Cellular Biochemistry 1997, 64: 505-13. PMID: 9057108, DOI: 10.1002/(sici)1097-4644(19970301)64:3<505::aid-jcb17>3.0.co;2-e.
- Cohen CR, Mills I, Du W, Kamal K, Sumpio BE. Activation of the adenylyl cyclase/cyclic AMP/protein kinase A pathway in endothelial cells exposed to cyclic strain. Experimental Cell Research 1997, 231: 184-9. PMID: 9056425, DOI: 10.1006/excr.1996.3450.
- Evans L, Frenkel L, Brophy CM, Rosales O, Sudhaker CB, Li G, Du W, Sumpio BE. Activation of diacylglycerol in cultured endothelial cells exposed to cyclic strain. The American Journal Of Physiology 1997, 272: C650-6. PMID: 9124309, DOI: 10.1152/ajpcell.1997.272.2.C650.
- Oluwole BO, Du W, Mills I, Sumpio BE. Gene regulation by mechanical forces. Endothelium : Journal Of Endothelial Cell Research 1997, 5: 85-93. PMID: 9237042, DOI: 10.3109/10623329709079866.
- Watase M, Awolesi MA, Ricotta J, Sumpio BE. Effect of pressure on cultured smooth muscle cells. Life Sciences 1997, 61: 987-96. PMID: 9296337, DOI: 10.1016/s0024-3205(97)00603-6.
- Murata K, Mills I, Sumpio BE. Protein phosphatase 2A in stretch-induced endothelial cell proliferation. Journal Of Cellular Biochemistry 1996, 63: 311-9. PMID: 8913882, DOI: 10.1002/(SICI)1097-4644(19961201)63:3%3C311::AID-JCB6%3E3.0.CO;2-#.
- Kamal K, Powell RJ, Sumpio BE. The pathobiology of diabetes mellitus: implications for surgeons. Journal Of The American College Of Surgeons 1996, 183: 271-89. PMID: 8784324.
- Yano Y, Geibel J, Sumpio BE. Tyrosine phosphorylation of pp125FAK and paxillin in aortic endothelial cells induced by mechanical strain. The American Journal Of Physiology 1996, 271: C635-49. PMID: 8770005, DOI: 10.1152/ajpcell.1996.271.2.C635.
- Basson MD, Li GD, Hong F, Han O, Sumpio BE. Amplitude-dependent modulation of brush border enzymes and proliferation by cyclic strain in human intestinal Caco-2 monolayers. Journal Of Cellular Physiology 1996, 168: 476-88. PMID: 8707883, DOI: 10.1002/(SICI)1097-4652(199608)168:2<476::AID-JCP26>3.0.CO;2-#.
- Yano Y, Saito Y, Narumiya S, Sumpio BE. Involvement of rho p21 in cyclic strain-induced tyrosine phosphorylation of focal adhesion kinase (pp125FAK), morphological changes and migration of endothelial cells. Biochemical And Biophysical Research Communications 1996, 224: 508-15. PMID: 8702419, DOI: 10.1006/bbrc.1996.1057.
- Powell RJ, Carruth JA, Basson MD, Bloodgood R, Sumpio BE. Matrix-specific effect of endothelial control of smooth muscle cell migration. Journal Of Vascular Surgery 1996, 24: 51-7. PMID: 8691527, DOI: 10.1016/s0741-5214(96)70144-1.
- Koo JT, Sawyer MD, Powell RJ, Sumpio BE. Transcriptional regulation of endothelin. Surgical Technology International 1996, 5: 276-82. PMID: 15858752.
- Du W, Mills I, Sumpio BE. Cyclic strain causes heterogeneous induction of transcription factors, AP-1, CRE binding protein and NF-kB, in endothelial cells: species and vascular bed diversity. Journal Of Biomechanics 1995, 28: 1485-91. PMID: 8666588, DOI: 10.1016/0021-9290(95)00096-8.
- Awolesi MA, Sessa WC, Sumpio BE. Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells. The Journal Of Clinical Investigation 1995, 96: 1449-54. PMID: 7544806, PMCID: PMC185768, DOI: 10.1172/JCI118181.
- McMillen MA, Sumpio BE. Endothelins: polyfunctional cytokines. Journal Of The American College Of Surgeons 1995, 180: 621-37. PMID: 7749544.
- Oluwole BO, McMIllen M, Sumpio BE. Endothelial cell control of vasomotor tone. Annals Of Vascular Surgery 1995, 9: 293-301. PMID: 7543275, DOI: 10.1007/BF02135291.
- McMillen MA, Huribal M, Cunningham ME, Kumar R, Sumpio BE. Endothelin-1 increases intracellular calcium in human monocytes and causes production of interleukin-6. Critical Care Medicine 1995, 23: 34-40. PMID: 8001384, DOI: 10.1097/00003246-199501000-00009.
- McMillen MA, Sumpio BE. Endothelial-leukocyte interactions in the neutrophil cascade. American Journal Of Surgery 1995, 169: 186-7. PMID: 7817990, DOI: 10.1016/s0002-9610(99)80130-5.
- Gusberg RJ, Peterec SM, Sumpio BE, Meier GH. Splenomegaly and variceal bleeding--hemodynamic basis and treatment implications. Hepato-gastroenterology 1994, 41: 573-7. PMID: 7721248.
- Mills I, Murata K, Packer CS, Sumpio BE. Cyclic strain stimulates dephosphorylation of the 20kDa regulatory myosin light chain in vascular smooth muscle cells. Biochemical And Biophysical Research Communications 1994, 205: 79-84. PMID: 7999114, DOI: 10.1006/bbrc.1994.2632.
- Sumpio BE, Li G, Deckelbaum LI, Gasparro FP. Inhibition of smooth muscle cell proliferation by visible light-activated psoralen. Circulation Research 1994, 75: 208-13. PMID: 8033334, DOI: 10.1161/01.res.75.2.208.
- Awolesi MA, Widmann MD, Sessa WC, Sumpio BE. Cyclic strain increases endothelial nitric oxide synthase activity. Surgery 1994, 116: 439-44; discussion 444-5. PMID: 7519368.
- Huribal M, Kumar R, Cunningham ME, Sumpio BE, McMillen MA. Endothelin-stimulated monocyte supernatants enhance neutrophil superoxide production. Shock (Augusta, Ga.) 1994, 1: 184-7. PMID: 7735949, DOI: 10.1097/00024382-199403000-00005.
- Gollin G, Ward B, Meier GH, Sumpio BE, Gusberg RJ. Central splanchnic venous thrombosis. Often unsuspected, usually uncomplicated. Journal Of Clinical Gastroenterology 1994, 18: 109-13. PMID: 8189002, DOI: 10.1097/00004836-199403000-00005.
- Sumpio BE, Widmann MD, Ricotta J, Awolesi MA, Watase M. Increased ambient pressure stimulates proliferation and morphologic changes in cultured endothelial cells. Journal Of Cellular Physiology 1994, 158: 133-9. PMID: 8263020, DOI: 10.1002/jcp.1041580117.
- Wiersbitzky M, Mills I, Sumpio BE, Gewirtz H. Chronic cyclic strain reduces adenylate cyclase activity and stimulatory G protein subunit levels in coronary smooth muscle cells. Experimental Cell Research 1994, 210: 52-5. PMID: 8269996, DOI: 10.1006/excr.1994.1008.
- Widmann MD, Sumpio BE. Lipoprotein (a): a risk factor for peripheral vascular disease. Annals Of Vascular Surgery 1993, 7: 446-51. PMID: 8268090, DOI: 10.1007/BF02002128.
- Wang ZG, Li G, Wu J, Du W, Pu L, Zhang H, Wang D, Sumpio BE. Enhanced patency of venous Dacron grafts by endothelial cell sodding. Annals Of Vascular Surgery 1993, 7: 429-36. PMID: 8268088, DOI: 10.1007/BF02002126.
- Brophy CM, Evans L, Sumpio BE. Defecation syncope secondary to functional inferior vena caval obstruction during a Valsalva maneuver. Annals Of Vascular Surgery 1993, 7: 374-7. PMID: 8268080, DOI: 10.1007/BF02002893.
- Gasparro FP, Gattolin P, Olack GA, Deckelbaum LI, Sumpio BE. The excitation of 8-methoxypsoralen with visible light: reversed phase HPLC quantitation of monoadducts and cross-links. Photochemistry And Photobiology 1993, 57: 1007-10. PMID: 8367529, DOI: 10.1111/j.1751-1097.1993.tb02963.x.
- Sumpio BE, Phan SM, Gasparro FP, Deckelbaum LI. Control of smooth muscle cell proliferation by psoralen photochemotherapy. Journal Of Vascular Surgery 1993, 17: 1010-6; discussion 1016-8. PMID: 8505779, DOI: 10.1067/mva.1993.45747.
- McMillen MA, Huribal M, Kumar R, Sumpio BE. Endothelin-stimulated human monocytes produce prostaglandin E2 but not leukotriene B4. The Journal Of Surgical Research 1993, 54: 331-5. PMID: 8392650, DOI: 10.1006/jsre.1993.1053.
- Brophy CM, Mills I, Rosales O, Isales C, Sumpio BE. Phospholipase C: a putative mechanotransducer for endothelial cell response to acute hemodynamic changes. Biochemical And Biophysical Research Communications 1993, 190: 576-81. PMID: 8427600, DOI: 10.1006/bbrc.1993.1087.
- Deckelbaum LI, Scott JJ, Stetz ML, O'Brien KM, Sumpio BE, Madri JA, Bell L. Photoinhibition of smooth muscle cell migration: potential therapy for restenosis. Lasers In Surgery And Medicine 1993, 13: 4-11. PMID: 8426525, DOI: 10.1002/lsm.1900130104.
- Rosales OR, Isales C, Nathanson M, Sumpio BE. Immunocytochemical expression and localization of protein kinase C in bovine aortic endothelial cells. Biochemical And Biophysical Research Communications 1992, 189: 40-6. PMID: 1449492, DOI: 10.1016/0006-291x(92)91522-r.
- Widmann MD, Letsou GV, Phan S, Baldwin JC, Sumpio BE. Isolation and characterization of rabbit cardiac endothelial cells: response to cyclic strain and growth factors in vitro. The Journal Of Surgical Research 1992, 53: 331-4. PMID: 1405613, DOI: 10.1016/0022-4804(92)90057-7.
- Rosales OR, Sumpio BE. Protein kinase C is a mediator of the adaptation of vascular endothelial cells to cyclic strain in vitro. Surgery 1992, 112: 459-66. PMID: 1379381.
- Iba T, Mills I, Sumpio BE. Intracellular cyclic AMP levels in endothelial cells subjected to cyclic strain in vitro. The Journal Of Surgical Research 1992, 52: 625-30. PMID: 1326680, DOI: 10.1016/0022-4804(92)90140-u.
- Sumpio BE. Molecular biology of the vascular system: fundamental concepts and the tools. Journal Of Vascular Surgery 1992, 15: 906-7. PMID: 1578561, DOI: 10.1016/0741-5214(92)90743-r.
- Rosales OR, Sumpio BE. Changes in cyclic strain increase inositol trisphosphate and diacylglycerol in endothelial cells. The American Journal Of Physiology 1992, 262: C956-62. PMID: 1566821, DOI: 10.1152/ajpcell.1992.262.4.C956.
- Widmann MD, Sumpio BE. Persistent hypoglossal artery: An anomaly leading to false-positive carotid duplex sonography. Annals Of Vascular Surgery 1992, 6: 176-8. PMID: 1599838, DOI: 10.1007/BF02042743.
- Iba T, Sumpio BE. Tissue plasminogen activator expression in endothelial cells exposed to cyclic strain in vitro. Cell Transplantation 1992, 1: 43-50. PMID: 1285345, DOI: 10.1177/096368979200100108.
- Sumpio BE, Phan S. Nephrotoxic potential of FK 506. Transplantation Proceedings 1991, 23: 2789-90. PMID: 1721278.
- Iba T, Maitz S, Furbert T, Rosales O, Widmann MD, Spillane B, Shin T, Sonoda T, Sumpio BE. Effect of cyclic stretch on endothelial cells from different vascular beds. Circulatory Shock 1991, 35: 193-8. PMID: 1777956.
- Iba T, Sumpio BE. Morphological response of human endothelial cells subjected to cyclic strain in vitro. Microvascular Research 1991, 42: 245-54. PMID: 1779881, DOI: 10.1016/0026-2862(91)90059-k.
- Rodriguez R, Stepke M, Maitz S, Cuono CB, Sumpio BE. Amelioration of renal ischemic injury by phosphocreatine. The Journal Of Surgical Research 1991, 51: 271-4. PMID: 1921364, DOI: 10.1016/0022-4804(91)90106-v.
- Sumpio BE. Hemodynamic forces and the biology of the endothelium: signal transduction pathways in endothelial cells subjected to physical forces in vitro. Journal Of Vascular Surgery 1991, 13: 744-6. PMID: 2027223, DOI: 10.1016/0741-5214(91)90372-2.
- Iba T, Shin T, Sonoda T, Rosales O, Sumpio BE. Stimulation of endothelial secretion of tissue-type plasminogen activator by repetitive stretch. The Journal Of Surgical Research 1991, 50: 457-60. PMID: 1903823, DOI: 10.1016/0022-4804(91)90024-g.
- Garrand TJ, Stetz ML, O'Brien KM, Gindi GR, Sumpio BE, Deckelbaum LI. Design and evaluation of a fiberoptic fluorescence guided laser recanalization system. Lasers In Surgery And Medicine 1991, 11: 106-16. PMID: 2034008, DOI: 10.1002/lsm.1900110204.
- Stimulation of adenylate cyclase activity in cultured endothelial cells subjected to cyclic stretch.Letsou GV, Rosales O, Maitz S, Vogt A, Sumpio BE. Stimulation of adenylate cyclase activity in cultured endothelial cells subjected to cyclic stretch. The Journal Of Cardiovascular Surgery 1990, 31: 634-9. PMID: 2229164.
- Sumpio BE, Widmann MD. Enhanced production of endothelium-derived contracting factor by endothelial cells subjected to pulsatile stretch. Surgery 1990, 108: 277-81; discussion 281-2. PMID: 2200155.
- Sumpio BE, Banes AJ, Link GW, Iba T. Modulation of endothelial cell phenotype by cyclic stretch: inhibition of collagen production. The Journal Of Surgical Research 1990, 48: 415-20. PMID: 2352417, DOI: 10.1016/0022-4804(90)90005-m.
- Sumpio BE, Upchurch GR, Johnson G. The influence of perfusate viscosity, RBC deformability and drag on the function of an isolated perfused rat kidney. The Journal Of Surgical Research 1989, 46: 4-8. PMID: 2915534, DOI: 10.1016/0022-4804(89)90174-1.
- Sumpio BE, Banes AJ, Link WG, Johnson G. Enhanced collagen production by smooth muscle cells during repetitive mechanical stretching. Archives Of Surgery (Chicago, Ill. : 1960) 1988, 123: 1233-6. PMID: 3178470, DOI: 10.1001/archsurg.1988.01400340059010.
- Sumpio BE, Banes AJ. Prostacyclin synthetic activity in cultured aortic endothelial cells undergoing cyclic mechanical deformation. Surgery 1988, 104: 383-9. PMID: 3135629.
- Buckley MJ, Banes AJ, Levin LG, Sumpio BE, Sato M, Jordan R, Gilbert J, Link GW, Tran Son Tay R. Osteoblasts increase their rate of division and align in response to cyclic, mechanical tension in vitro. Bone And Mineral 1988, 4: 225-36. PMID: 2847838.
- Sumpio BE, Banes AJ. Response of porcine aortic smooth muscle cells to cyclic tensional deformation in culture. The Journal Of Surgical Research 1988, 44: 696-701. PMID: 3379947, DOI: 10.1016/0022-4804(88)90103-5.
- Sumpio BE, O'Leary G, Gusberg RJ. Variceal bleeding, hypersplenism, and systemic mastocytosis. Pathophysiology and management. Archives Of Surgery (Chicago, Ill. : 1960) 1988, 123: 767-9. PMID: 3130825, DOI: 10.1001/archsurg.1988.01400300113020.
- Sumpio BE. Cyclosporine toxicity in the isolated perfused rat kidney. Transplantation Proceedings 1988, 20: 712-6. PMID: 3388509.
- Sumpio BE, Banes AJ, Buckley M, Johnson G. Alterations in aortic endothelial cell morphology and cytoskeletal protein synthesis during cyclic tensional deformation. Journal Of Vascular Surgery 1988, 7: 130-8. PMID: 3336119.
- Sumpio BE, Baue AE, Chaudry IH. Alleviation of cyclosporine nephrotoxicity with verapamil and ATP-MgCl2. Mitochondrial respiratory and calcium studies. Annals Of Surgery 1987, 206: 655-60. PMID: 3499878, PMCID: PMC1493310, DOI: 10.1097/00000658-198711000-00017.
- Sumpio BE, Gusberg RJ. Aortic thrombosis with paraplegia: an unusual consequence of blunt abdominal trauma. Journal Of Vascular Surgery 1987, 6: 412-4. PMID: 3309383, DOI: 10.1067/mva.1987.avs0060412.
- Sumpio BE, Banes AJ, Levin LG, Johnson G. Mechanical stress stimulates aortic endothelial cells to proliferate. Journal Of Vascular Surgery 1987, 6: 252-6. PMID: 3625881.
- Sumpio BE, Jennings TA, Merino MJ, Sullivan PD. Adenoid cystic carcinoma of the breast. Data from the Connecticut Tumor Registry and a review of the literature. Annals Of Surgery 1987, 205: 295-301. PMID: 3030200, PMCID: PMC1492723, DOI: 10.1097/00000658-198703000-00013.
- Sumpio BE, Hull MJ, Baue AE, Chaudry IH. Comparison of effects of ATP-MgCl2 and adenosine-MgCl2 on renal function following ischemia. The American Journal Of Physiology 1987, 252: R388-93. PMID: 3492930, DOI: 10.1152/ajpregu.1987.252.2.R388.
- Sumpio BE, Dwyer JM, Flye MW. T-lymphocyte subsets in renal allograft recipients treated with cyclosporine and azathioprine. Annals Of Surgery 1987, 205: 49-53. PMID: 3541801, PMCID: PMC1492880, DOI: 10.1097/00000658-198701000-00009.
- Sumpio BE, Hull MJ, Baue AE, Chaudry IH. Effects of ATP-MgCl2 and adenosine-MgCl2 administration on intracellular ATP levels in the kidney. Biochimica Et Biophysica Acta 1986, 862: 303-8. PMID: 3778894, DOI: 10.1016/0005-2736(86)90232-4.
- T-lymphocyte subsets in renal allograft recipients undergoing different immunosuppression protocols.Sumpio BE, Dwyer JM, Flye MW. T-lymphocyte subsets in renal allograft recipients undergoing different immunosuppression protocols. Current Surgery 1986, 43: 502-5. PMID: 3542396.
- Sumpio BE, Ballantyne GH, Zdon MJ, Modlin IM. Perforated appendicitis and obstructing colonic carcinoma in the elderly. Diseases Of The Colon And Rectum 1986, 29: 668-70. PMID: 3757711, DOI: 10.1007/bf02560335.
- Morse SS, Strauss EB, Sumpio BE. Apparent arterial occlusion due to pneumatic antishock garment: pitfall in trauma angiography (case report). AJR. American Journal Of Roentgenology 1986, 147: 391-2. PMID: 3487959, DOI: 10.2214/ajr.147.2.391.
- Sumpio BE, Traquina DN, Gusberg RJ. Results of aortic grafting in occlusive vs aneurysmal disease. Archives Of Surgery (Chicago, Ill. : 1960) 1985, 120: 817-9. PMID: 4015373, DOI: 10.1001/archsurg.1985.01390310055012.
- Sumpio BE, Chaudry IH, Baue AE. Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. II. Effects on gentamicin-treated isolated perfused kidneys. The Journal Of Surgical Research 1985, 38: 438-45. PMID: 3872964, DOI: 10.1016/0022-4804(85)90059-9.
- Sumpio BE, Chaudry IH, Baue AE. Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. 1. Effects on the cis-diamminedichloroplatinum-treated isolated perfused kidneys. The Journal Of Surgical Research 1985, 38: 429-37. PMID: 3872963, DOI: 10.1016/0022-4804(85)90058-7.
- Sumpio BE, Chaudry IH, Baue AE. Adenosine triphosphate--magnesium chloride ameliorates reperfusion injury following ischemia as determined by phosphorus nuclear magnetic resonance. Archives Of Surgery (Chicago, Ill. : 1960) 1985, 120: 233-40. PMID: 3872113, DOI: 10.1001/archsurg.1985.01390260091013.
- Sumpio BE, Chaudry IH, Clemens MG, Baue AE. Accelerated functional recovery of isolated rat kidney with ATP-MgCl2 after warm ischemia. The American Journal Of Physiology 1984, 247: R1047-53. PMID: 6334446, DOI: 10.1152/ajpregu.1984.247.6.R1047.
- Camargo MJ, Sumpio BE, Maack T. Renal hydrolysis of absorbed protein: influence of load and lysosomal pH. The American Journal Of Physiology 1984, 247: F656-64. PMID: 6093557, DOI: 10.1152/ajprenal.1984.247.4.F656.
- Sumpio BE, Ernstoff MS, Kirkwood JM. Urinary excretion of interferon, albumin, and beta 2-microglobulin during interferon treatment. Cancer Research 1984, 44: 3599-603. PMID: 6378373.
- Camargo MJ, Sumpio BE, Maack T. Kinetics of renal catabolism of absorbed proteins: influence of lysosomal pH. Contributions To Nephrology 1984, 42: 19-29. PMID: 6099789, DOI: 10.1159/000409957.
- Sumpio BE, Maack T. Kinetics, competition, and selectivity of tubular absorption of proteins. The American Journal Of Physiology 1982, 243: F379-92. PMID: 7124951, DOI: 10.1152/ajprenal.1982.243.4.F379.
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