Xuchen Zhang, MD, PhD
Biography
Xuchen Zhang, MD, PhD, is a pathologist who specializes in diagnosing liver and gastrointestinal conditions, as well as in lung diseases. Dr. Zhang is a fourth-generation physician in his family. “My father, grandfather, and great-grandfather were doctors,” he says.
On a daily basis, Dr. Zhang examines tissue samples and biopsies from patients with suspected gastrointestinal and liver diseases, and renders a pathology diagnosis. “My diagnosis can help the clinician to choose the best treatment and management of the disease,” Dr. Zhang says. “That’s the part I most enjoy about my job.”
At Yale School of Medicine, Dr. Zhang is an associate professor of pathology. Dr. Zhang’s research interests include lung diseases, inflammatory bowel disease, liver tumors, and cancers related to the liver and digestive tract. “I actively collaborate with other investigators at Yale in the areas of lung, liver, and gastrointestinal pathology,” Dr. Zhang says. In addition to these diverse specialties and interest, Dr. Zhang also contributes to research on how to better classify the different types of colon cancer and liver cancer.
Titles
- Professor of Pathology
- Director, Gastrointestinal and Liver Pathology Program, Pathology
Education & Training
- PhDChinese Academy of Medical Sciences (2000)
- MSBeijing Univ of Chinese Medicine (1994)
- MDChengde Medical College (1988)
- ResidencyState University of New York (SUNY) at Downstate Medical Center
- FellowshipMount Sinai School of Medicine
Additional Information
- The Averill Liebow Award for Excellence in the Teaching of Pathology Residents: Department of Pathology, Yale University School of Medicine (2013)
- Chair’s Award for Outstanding Scholarship: Department of Pathology. SUNY Downstate Medical Center (2011)
- Outstanding performance: SUNY Downstate Medical Center (2011)
- Young Investigator Award: Society of Cardiovascular Pathology (2011)
- AB of Pathology, Anatomic & Clinical Pathology (2011)
- Jiao J, Tang H, Sun N, Zhang X. Artificial intelligence–aided steatosis assessment in donor livers according to the Banff consensus recommendations. American Journal Of Clinical Pathology 2024, aqae053. PMID: 38716796, DOI: 10.1093/ajcp/aqae053.
- Sakuma I, Gaspar R, Luukkonen P, Kahn M, Zhang D, Zhang X, Murray S, Golla J, Vatner D, Samuel V, Petersen K, Shulman G. Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and overnutrition. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2312666120. PMID: 38127985, PMCID: PMC10756285, DOI: 10.1073/pnas.2312666120.
- Tang H, Jiao J, Lin J, Zhang X, Sun N. Detection of Large-Droplet Macrovesicular Steatosis in Donor Livers Based on Segment-Anything Model. Laboratory Investigation 2023, 104: 100288. PMID: 37977550, DOI: 10.1016/j.labinv.2023.100288.
- Hou T, Yang Z, Zhang Q, Zhang X, Liao X, Lin J. Histology Shift in Esophageal Cancer Between Biopsies and Resections After Neoadjuvant Therapy: A Pilot Study. International Journal Of Surgical Pathology 2023, 10668969231208029. PMID: 37899731, DOI: 10.1177/10668969231208029.
- Song J, Lv H, Liu B, Hao M, Taylor H, Zhang X, Li D, Huang Y. Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production. Molecular Metabolism 2023, 78: 101828. PMID: 37898449, PMCID: PMC10641683, DOI: 10.1016/j.molmet.2023.101828.
- Zhang X, Shan P, Otterbein L, Alam J, Flavell R, Davis R, Choi A, Lee P. Correction: Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. Journal Of Biological Chemistry 2023, 299: 105304. PMID: 37826982, PMCID: PMC10570935, DOI: 10.1016/j.jbc.2023.105304.
- Tanaka M, Jeong J, Thomas C, Zhang X, Zhang P, Saruwatari J, Kondo R, McConnell M, Utsumi T, Iwakiri Y. The Sympathetic Nervous System Promotes Hepatic Lymphangiogenesis, which Is Protective Against Liver Fibrosis. American Journal Of Pathology 2023, 193: 2182-2202. PMID: 37673329, PMCID: PMC10699132, DOI: 10.1016/j.ajpath.2023.08.004.
- Jeong J, Tanaka M, Yang Y, Arefyev N, DiRito J, Tietjen G, Zhang X, McConnell M, Utsumi T, Iwakiri Y. An optimized visualization and quantitative protocol for in-depth evaluation of lymphatic vessel architecture in the liver. AJP Gastrointestinal And Liver Physiology 2023, 325: g379-g390. PMID: 37605828, PMCID: PMC10887843, DOI: 10.1152/ajpgi.00139.2023.
- Fernandez A, Robbins C, Gaule P, Agostini-Vulaj D, Anders R, Bellizzi A, Chen W, Chen Z, Gopal P, Zhao L, Lisovsky M, Liu X, Shia J, Wang H, Yang Z, McCann L, Chan Y, Weidler J, Bates M, Zhang X, Rimm D. Multi-Institutional Study of Pathologist Reading of the Programmed Cell Death Ligand-1 Combined Positive Score Immunohistochemistry Assay for Gastric or Gastroesophageal Junction Cancer. Modern Pathology 2023, 36: 100128. PMID: 36889057, PMCID: PMC10198879, DOI: 10.1016/j.modpat.2023.100128.
- Luukkonen P, Sakuma I, Gaspar R, Mooring M, Nasiri A, Kahn M, Zhang X, Zhang D, Sammalkorpi H, Penttilä A, Orho-Melander M, Arola J, Juuti A, Zhang X, Yimlamai D, Yki-Järvinen H, Petersen K, Shulman G. Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2217543120. PMID: 36669104, PMCID: PMC9942818, DOI: 10.1073/pnas.2217543120.
- Santana J, Shewarega A, Nam D, Kahl V, Madoff D, Zhang X, Chapiro J. Experimental VX2 Rabbit Liver Tumor Model in Carbon Tetrachloride–Induced Cirrhosis of the Liver. Journal Of Vascular And Interventional Radiology 2022, 34: 404-408.e1. PMID: 36473611, PMCID: PMC11037556, DOI: 10.1016/j.jvir.2022.11.026.
- Baine M, Zhang X. Lymphomatoid Granulomatosis Versus Granulomatosis with Polyangiitis. 2022, 213-218. DOI: 10.1007/978-3-031-14402-8_35.
- Baine M, Cai G, Zhang X. Pleomorphic Carcinoma Versus Sarcomatoid Malignant Mesothelioma. 2022, 137-145. DOI: 10.1007/978-3-031-14402-8_23.
- Harris ZM, Sun Y, Joerns J, Clark B, Hu B, Korde A, Sharma L, Shin HJ, Manning EP, Placek L, Unutmaz D, Stanley G, Chun H, Sauler M, Rajagopalan G, Zhang X, Kang MJ, Koff JL. Epidermal Growth Factor Receptor Inhibition Is Protective in Hyperoxia-Induced Lung Injury. Oxidative Medicine And Cellular Longevity 2022, 2022: 9518592. PMID: 36193076, PMCID: PMC9526641, DOI: 10.1155/2022/9518592.
- Jiao J, Zhang X. Post-infantile Giant Cell Hepatitis: A Literature Review and Meta-analysis. Journal Of Clinical And Translational Pathology 2022, 000: 000-000. DOI: 10.14218/jctp.2022.00016.
- Dolezal D, Zhang X, Harigopal M. Increased Expression of LEF1 and β-Catenin in Invasive Micropapillary Carcinoma of the Breast is Associated With Lymphovascular Invasion and Lymph Node Metastasis. Applied Immunohistochemistry & Molecular Morphology 2022, 30: 557-565. PMID: 35960138, DOI: 10.1097/pai.0000000000001052.
- Lai J, Wang HL, Zhang X, Wang H, Liu X. Pathologic Diagnosis of Nonalcoholic Fatty Liver Disease. Archives Of Pathology & Laboratory Medicine 2022, 146: 940-946. PMID: 34871361, DOI: 10.5858/arpa.2021-0339-RA.
- Zhang X, Jain D. The many faces and pathologic diagnostic challenges of autoimmune hepatitis. Human Pathology 2022, 132: 114-125. PMID: 35753409, DOI: 10.1016/j.humpath.2022.06.019.
- Wang D, González IA, Russo PA, Jain D, Zhang X. Prominent Pseudoacini in Focal Nodular Hyperplasia. The American Journal Of Surgical Pathology 2022, 46: 1380-1385. PMID: 35749760, DOI: 10.1097/pas.0000000000001931.
- Chava S, Bugide S, Zhang X, Gupta R, Wajapeyee N. Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis. IScience 2022, 25: 104211. PMID: 35494243, PMCID: PMC9048069, DOI: 10.1016/j.isci.2022.104211.
- Wang JD, Sebastian C, Walther Z, Suresh T, Lacy J, Zhang X, Jain D. An Appraisal of Immunohistochemical Stain Use in Hepatic Metastasis Highlights the Effectiveness of the Individualized, Case-Based Approach: Analysis of Data From a Tertiary Care Medical Center. Archives Of Pathology & Laboratory Medicine 2022, 147: 185-192. PMID: 35512224, DOI: 10.5858/arpa.2021-0457-oa.
- Ho S, Kuo E, Allende D, Wang HL, Westerhoff M, Graham RP, Saxena R, Gonzalez RS, Fiel MI, Yang Z, Zhang X, Liu X. Heterogeneity of hepatic steatosis definitions and reporting of donor liver frozen sections among pathologists: A multicenter survey. Liver Transplantation 2022, 28: 1540-1542. PMID: 35377545, DOI: 10.1002/lt.26466.
- Wang X, Zhang X. Hepatocellular adenoma: Where are we now? World Journal Of Gastroenterology 2022, 28: 1384-1393. PMID: 35582672, PMCID: PMC9048476, DOI: 10.3748/wjg.v28.i14.1384.
- Berz AM, Santana JG, Iseke S, Gross M, Pekurovsky V, Laage Gaupp F, Savic LJ, Borde T, Gottwald LA, Boustani AM, Gebauer B, Lin M, Zhang X, Schlachter T, Madoff DC, Chapiro J. Impact of Chemoembolic Regimen on Immune Cell Recruitment and Immune Checkpoint Marker Expression following Transcatheter Arterial Chemoembolization in a VX2 Rabbit Liver Tumor Model. Journal Of Vascular And Interventional Radiology 2022, 33: 764-774.e4. PMID: 35346859, PMCID: PMC9344951, DOI: 10.1016/j.jvir.2022.03.026.
- Nguyen RY, Xiao H, Gong X, Arroyo A, Cabral AT, Fischer TT, Flores KM, Zhang X, Robert ME, Ehrlich BE, Mak M. Cytoskeletal dynamics regulates stromal invasion behavior of distinct liver cancer subtypes. Communications Biology 2022, 5: 202. PMID: 35241781, PMCID: PMC8894393, DOI: 10.1038/s42003-022-03121-5.
- Cadamuro M, Fabris L, Zhang X, Strazzabosco M. Tumor microenvironment and immunology of cholangiocarcinoma. Hepatoma Research 2022, 8: null-null. DOI: 10.20517/2394-5079.2021.140.
- Li H, Zhang X, Finberg KE, Walther Z, Jain D, Gibson J. Pathogenic BRCA2 germline variants in combined hepatocellular‐cholangiocarcinoma. Pathology International 2021, 72: 138-140. PMID: 34808016, DOI: 10.1111/pin.13188.
- González IA, Fuller LD, Zhang X, Papke DJ, Zhao L, Zhang D, Liao X, Liu X, Fiel MI, Zhang X. Development of a Scoring System to Differentiate Amiodarone-Induced Liver Injury From Alcoholic Steatohepatitis. American Journal Of Clinical Pathology 2021, 157: 434-442. PMID: 34596220, DOI: 10.1093/ajcp/aqab142.
- Jain A, Mazer B, Deng Y, Ciarleglio M, Jain D, Taddei T, Zhang X. Hepatocellular Carcinoma. American Journal Of Clinical Pathology 2021, 157: 305-313. PMID: 34542582, DOI: 10.1093/ajcp/aqab125.
- Ranjan K, Hedl M, Sinha S, Zhang X, Abraham C. Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response. Journal Of Clinical Investigation 2021, 131: e145472. PMID: 34623328, PMCID: PMC8409591, DOI: 10.1172/jci145472.
- Reschke M, DiRito JR, Stern D, Day W, Plebanek N, Harris M, Hosgood SA, Nicholson ML, Haakinson DJ, Zhang X, Mehal WZ, Ouyang X, Pober JS, Saltzman WM, Tietjen GT. A digital pathology tool for quantification of color features in histologic specimens. Bioengineering & Translational Medicine 2021, 7: e10242. PMID: 35111944, PMCID: PMC8780932, DOI: 10.1002/btm2.10242.
- Kondo R, Kawaguchi N, McConnell MJ, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Sun Z, Utsumi T, Strazzabosco M, Iwakiri Y. Pathological characteristics of liver sinusoidal thrombosis in COVID‐19 patients: A series of 43 cases. Hepatology Research 2021, 51: 1000-1006. PMID: 34260803, PMCID: PMC8444906, DOI: 10.1111/hepr.13696.
- Rottmann BG, Patel N, Ahmed M, Deng Y, Ciarleglio M, Vyas M, Jain D, Zhang X. Clinicopathological significance of neutrophil-rich colorectal carcinoma. Journal Of Clinical Pathology 2021, 76: 34-39. PMID: 34312298, PMCID: PMC10910606, DOI: 10.1136/jclinpath-2021-207702.
- Pischel L, Radcliffe C, Vilchez GA, Charifa A, Zhang XC, Grant M. Bartonellosis in transplant recipients: A retrospective single center experience. World Journal Of Transplantation 2021, 11: 244-253. PMID: 34164299, PMCID: PMC8218350, DOI: 10.5500/wjt.v11.i6.244.
- Patil PA, Taddei T, Jain D, Zhang X. HNF-1β is a More Sensitive and Specific Marker Than C-Reactive Protein for Identifying Biliary Differentiation in Primary Hepatic Carcinomas. Archives Of Pathology & Laboratory Medicine 2021, 146: 220-226. PMID: 34086854, DOI: 10.5858/arpa.2020-0725-oa.
- Papke Jr. D, Dong F, Zhang X, Kozielski R, Basturk O, Fletcher CDM, Zhao L. Calcifying nested stromal–epithelial tumor: a clinicopathologic and molecular genetic study of eight cases highlighting metastatic potential and recurrent CTNNB1 and TERT promoter alterations. Modern Pathology 2021, 34: 1696-1703. PMID: 33994539, DOI: 10.1038/s41379-021-00822-w.
- McConnell MJ, Kawaguchi N, Kondo R, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Lee A, Pine AB, Chun HJ, Zhang X, Fernandez-Hernando C, Qing H, Wang A, Price C, Sun Z, Utsumi T, Hwa J, Strazzabosco M, Iwakiri Y. Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy. Journal Of Hepatology 2021, 75: 647-658. PMID: 33991637, PMCID: PMC8285256, DOI: 10.1016/j.jhep.2021.04.050.
- Kumar D, Hafez O, Jain D, Zhang X. Can primary hepatocellular carcinoma histomorphology predict extrahepatic metastasis? Human Pathology 2021, 113: 39-46. PMID: 33905775, DOI: 10.1016/j.humpath.2021.04.008.
- Lu SX, Huang YH, Liu LL, Zhang CZ, Yang X, Yang YZ, Shao CK, Li JM, Xie D, Zhang X, Jain D, Yun JP. α-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study. British Journal Of Cancer 2021, 124: 1988-1996. PMID: 33824478, PMCID: PMC8184895, DOI: 10.1038/s41416-021-01363-4.
- Murtha TD, Cornman-Homonoff J, Ayyagari R, Zhang X, Salem RR. A Novel Treatment for Metastatic Serous Cystadenocarcinoma Using a Microwave Ablation: Case Report and Review of the Literature. Pancreas 2021, 50: 434-440. PMID: 33835976, DOI: 10.1097/mpa.0000000000001785.
- Saulino D, Chen R, Wang K, Shen M, Zhang X, Westerhoff M, Cheng J, Lin J, Zhang X, Feely M, Liu X. Characterization of Chronic Gastritis in Lynch Syndrome Patients With Gastric Adenocarcinoma. Gastroenterology Research 2021, 14: 13-20. PMID: 33737995, PMCID: PMC7935615, DOI: 10.14740/gr1359.
- Lo YC, Price C, Blenman K, Patil P, Zhang X, Robert ME. Checkpoint Inhibitor Colitis Shows Drug-Specific Differences in Immune Cell Reaction That Overlap With Inflammatory Bowel Disease and Predict Response to Colitis Therapy. American Journal Of Clinical Pathology 2021, 156: 214-228. PMID: 33555016, DOI: 10.1093/ajcp/aqaa217.
- Liang Y, Shi X, Zhang X, Zhang L. The prospective on molecular diagnostics of colorectal cancer and its clinical implications. 中华病理学杂志 2021, 50: 66-68. PMID: 33396991, DOI: 10.3760/cma.j.cn112151-20201120-00856.
- Oestmann PM, Wang CJ, Savic LJ, Hamm CA, Stark S, Schobert I, Gebauer B, Schlachter T, Lin M, Weinreb JC, Batra R, Mulligan D, Zhang X, Duncan JS, Chapiro J. Deep learning–assisted differentiation of pathologically proven atypical and typical hepatocellular carcinoma (HCC) versus non-HCC on contrast-enhanced MRI of the liver. European Radiology 2021, 31: 4981-4990. PMID: 33409782, PMCID: PMC8222094, DOI: 10.1007/s00330-020-07559-1.
- Yin F, Saad M, Lin J, Jackson CR, Ren B, Lawson C, Karamchandani DM, Bernabeu BQ, Jiang W, Dhir T, Zheng R, Schultz CW, Zhang D, Thomas CL, Zhang X, Lai J, Schild M, Zhang X, Xie H, Liu X. Splenic-vasculature involvement is associated with poor prognosis in resected distal pancreatic cancer. Gastroenterology Report 2020, 9: 139-145. PMID: 34026221, PMCID: PMC8128010, DOI: 10.1093/gastro/goaa084.
- Turbiville D, Zhang X. Calcifying fibrous tumor of the gastrointestinal tract: A clinicopathologic review and update. World Journal Of Gastroenterology 2020, 26: 5597-5605. PMID: 33071524, PMCID: PMC7545394, DOI: 10.3748/wjg.v26.i37.5597.
- Zhang X, Jain D. Updates in staging and pathologic evaluation of esophageal carcinoma following neoadjuvant therapy. Annals Of The New York Academy Of Sciences 2020, 1482: 163-176. PMID: 32892349, DOI: 10.1111/nyas.14462.
- Vyas M, Zhang X. Hepatocellular Carcinoma Role of Pathology in the Era of Precision Medicine. Clinics In Liver Disease 2020, 24: 591-610. PMID: 33012447, DOI: 10.1016/j.cld.2020.07.010.
- Irshaid L, Robert ME, Zhang X. Immune Checkpoint Inhibitor–Induced Upper Gastrointestinal Tract Inflammation Shows Morphologic Similarities to, but Is Immunologically Distinct From, Helicobacter pylori Gastritis and Celiac Disease. Archives Of Pathology & Laboratory Medicine 2020, 145: 191-200. PMID: 33501492, DOI: 10.5858/arpa.2019-0700-oa.
- Celli R, Zhang X. Gastrointestinal Ischemia and Vascular Disorders. 2020, 84-101. DOI: 10.1017/9781316823026.007.
- Tefera J, Revzin M, Chapiro J, Savic L, Mulligan D, Batra R, Taddei T, Jain D, Zhang X. Fibronodular hepatocellular carcinoma—a new variant of liver cancer: clinical, pathological and radiological correlation. Journal Of Clinical Pathology 2020, 74: 31-35. PMID: 32430483, PMCID: PMC7674234, DOI: 10.1136/jclinpath-2020-206574.
- Patil PA, Zhang X. Pathologic Manifestations of Gastrointestinal and Hepatobiliary Injury in Immune Checkpoint Inhibitor Therapy. Archives Of Pathology & Laboratory Medicine 2020, 145: 571-582. PMID: 32338534, DOI: 10.5858/arpa.2020-0070-ra.
- Johncilla M, Grover S, Zhang X, Jain D, Srivastava A. Morphological spectrum of immune check‐point inhibitor therapy‐associated gastritis. Histopathology 2020, 76: 531-539. PMID: 31692018, DOI: 10.1111/his.14029.
- Zhang D, Hart J, Ding X, Zhang X, Feely M, Yassan L, Alpert L, Soldevila-Pico C, Zhang X, Liu X, Lai J. Histologic patterns of liver injury induced by anti-PD-1 therapy. Gastroenterology Report 2019, 8: 50-55. PMID: 32467761, PMCID: PMC7244961, DOI: 10.1093/gastro/goz044.
- Patel N, Vyas M, Celli R, Jain D, Zhang X. Adverse Histologic Features in Colorectal Nonpedunculated Malignant Polyps With Nodal Metastasis. The American Journal Of Surgical Pathology 2019, 44: 241-246. PMID: 31498179, DOI: 10.1097/pas.0000000000001369.
- Beech C, Freedman-Weiss M, Salem R, Jain D, Zhang X. Pancreatic Intraductal Papillary Mucinous Neoplasm With Elevated Pre-Operative Cystic Carcinoembryonic Antigen Level: A Histopathologic Correlation. Gastroenterology Research 2019, 12: 185-190. PMID: 31523327, PMCID: PMC6731045, DOI: 10.14740/gr1201.
- Jeon Y, Benedict M, Taddei T, Jain D, Zhang X. Macrotrabecular Hepatocellular Carcinoma. The American Journal Of Surgical Pathology 2019, 43: 943-948. PMID: 31135484, DOI: 10.1097/pas.0000000000001289.
- Glucose Metabolic Reprogramming and Cell Proliferation Arrest in Colorectal Micropapillary CarcinomaVyas M, Patel N, Celli R, Wajapeyee N, Jain D, Zhang X. Glucose Metabolic Reprogramming and Cell Proliferation Arrest in Colorectal Micropapillary Carcinoma. Gastroenterology Research 2019, 12: 128-134. PMID: 31236153, PMCID: PMC6575135, DOI: 10.14740/gr1145.
- Hakim A, Zhang X, DeLisle A, Oral EA, Dykas D, Drzewiecki K, Assis DN, Silveira M, Batisti J, Jain D, Bale A, Mistry PK, Vilarinho S. Clinical utility of genomic analysis in adults with idiopathic liver disease. Journal Of Hepatology 2019, 70: 1214-1221. PMID: 31000363, PMCID: PMC6526061, DOI: 10.1016/j.jhep.2019.01.036.
- Benedict M, Zhang X. Calcifying Nested Stromal-Epithelial Tumor of the Liver: An Update and Literature Review. Archives Of Pathology & Laboratory Medicine 2018, 143: 264-268. PMID: 30354275, DOI: 10.5858/arpa.2017-0346-rs.
- Zhang X, Patil D, Odze RD, Zhao L, Lisovsky M, Guindi M, Riddell R, Bellizzi A, Yantiss RK, Nalbantoglu I, Appelman HD. The microscopic anatomy of the esophagus including the individual layers, specialized tissues, and unique components and their responses to injury. Annals Of The New York Academy Of Sciences 2018, 1434: 304-318. PMID: 29761508, DOI: 10.1111/nyas.13705.
- Charifa A, Zhang X. Morphologic and Immunohistochemical Characteristics of Anorectal Melanoma. International Journal Of Surgical Pathology 2018, 26: 725-729. PMID: 29759015, DOI: 10.1177/1066896918773177.
- Benedict M, Zhang X. Non-alcoholic fatty liver disease: An expanded review. World Journal Of Hepatology 2017, 9: 715-732. PMID: 28652891, PMCID: PMC5468341, DOI: 10.4254/wjh.v9.i16.715.
- Zhang X, Zhu H, Yang X, Adsay VN, Jain D. Post-obstructive cyst formation in pancreas and cystic acinar transformation: Are they same? Pathology - Research And Practice 2017, 213: 997-1001. PMID: 28599853, DOI: 10.1016/j.prp.2017.03.013.
- Vyas M, Wong S, Zhang X. Intestinal metaplasia of appendiceal endometriosis is not uncommon and may mimic appendiceal mucinous neoplasm. Pathology - Research And Practice 2016, 213: 39-44. PMID: 27913053, DOI: 10.1016/j.prp.2016.10.011.
- Lisovsky M, Westerhoff M, Zhang X. Lymphocytic esophagitis: a histologic pattern with emerging clinical ramifications. Annals Of The New York Academy Of Sciences 2016, 1381: 133-138. PMID: 27635640, DOI: 10.1111/nyas.13260.
- Gettinger S, Zhang X, Homer R, Possick J, Wurtz A, Goldberg S, Chiang A, Herbst R, Rubinowitz A. Pneumonitis in non-small cell lung cancer (NSCLC) patients treated with programmed death 1 (PD1) axis inhibitors. Journal Of Clinical Oncology 2016, 34: 9030-9030. DOI: 10.1200/jco.2016.34.15_suppl.9030.
- Zhang X, Homer R. Normal Development, Anatomy, Histology and Aging of the Lung. 2015, 1-37. DOI: 10.1142/9789814635011_0001.
- Benedict M, Galvao Neto A, Zhang X. Interval colorectal carcinoma: An unsolved debate. World Journal Of Gastroenterology 2015, 21: 12735-12741. PMID: 26668498, PMCID: PMC4671029, DOI: 10.3748/wjg.v21.i45.12735.
- Zhang X, Jain D. Pathology and Staging of Rectal Cancer. 2014, 35-56. DOI: 10.1007/978-1-4471-6609-2_4.
- Zhang X, Shan P, Homer R, Zhang Y, Petrache I, Mannam P, Lee PJ. Cathepsin E Promotes Pulmonary Emphysema via Mitochondrial Fission. American Journal Of Pathology 2014, 184: 2730-2741. PMID: 25239563, PMCID: PMC4188869, DOI: 10.1016/j.ajpath.2014.06.017.
- Celli R, Zhang X. Pathology of Alcoholic Liver Disease. Journal Of Clinical And Translational Hepatology 2014, 2: 103-109. PMID: 26357621, PMCID: PMC4521259, DOI: 10.14218/jcth.2014.00010.
- Zhang X, Ouyang J, Thung SN. Histopathologic Manifestations of Drug-induced Hepatotoxicity. Clinics In Liver Disease 2013, 17: 547-564. PMID: 24099017, DOI: 10.1016/j.cld.2013.07.004.
- Zhang X, Li J. Era of universal testing of microsatellite instability in colorectal cancer. World Journal Of Gastrointestinal Oncology 2013, 5: 12-9. PMID: 23556052, PMCID: PMC3613766, DOI: 10.4251/wjgo.v5.i2.12.
- ZHANG Y, ZHANG X, Shan P, Lee P. Toll-like Receptor 4 Mediates The Protective Effects Of Hsp70 During Hyperoxia. 2010, a2684-a2684. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2684.
- Zhang X, Shan P, Jiang G, Cohn L, Lee PJ. Toll-like receptor 4 deficiency causes pulmonary emphysema. Journal Of Clinical Investigation 2006, 116: 3050-3059. PMID: 17053835, PMCID: PMC1616193, DOI: 10.1172/jci28139.
- Zhang X, Lee P. Response to Comment on “Cutting Edge: TLR4 Deficiency Confers Susceptibility to Lethal Oxidant Lung Injury”. The Journal Of Immunology 2006, 176: 3857-3857. DOI: 10.4049/jimmunol.176.7.3857.
Biography
Xuchen Zhang, MD, PhD, is a pathologist who specializes in diagnosing liver and gastrointestinal conditions, as well as in lung diseases. Dr. Zhang is a fourth-generation physician in his family. “My father, grandfather, and great-grandfather were doctors,” he says.
On a daily basis, Dr. Zhang examines tissue samples and biopsies from patients with suspected gastrointestinal and liver diseases, and renders a pathology diagnosis. “My diagnosis can help the clinician to choose the best treatment and management of the disease,” Dr. Zhang says. “That’s the part I most enjoy about my job.”
At Yale School of Medicine, Dr. Zhang is an associate professor of pathology. Dr. Zhang’s research interests include lung diseases, inflammatory bowel disease, liver tumors, and cancers related to the liver and digestive tract. “I actively collaborate with other investigators at Yale in the areas of lung, liver, and gastrointestinal pathology,” Dr. Zhang says. In addition to these diverse specialties and interest, Dr. Zhang also contributes to research on how to better classify the different types of colon cancer and liver cancer.
Titles
- Professor of Pathology
- Director, Gastrointestinal and Liver Pathology Program, Pathology
Education & Training
- PhDChinese Academy of Medical Sciences (2000)
- MSBeijing Univ of Chinese Medicine (1994)
- MDChengde Medical College (1988)
- ResidencyState University of New York (SUNY) at Downstate Medical Center
- FellowshipMount Sinai School of Medicine
Additional Information
- The Averill Liebow Award for Excellence in the Teaching of Pathology Residents: Department of Pathology, Yale University School of Medicine (2013)
- Chair’s Award for Outstanding Scholarship: Department of Pathology. SUNY Downstate Medical Center (2011)
- Outstanding performance: SUNY Downstate Medical Center (2011)
- Young Investigator Award: Society of Cardiovascular Pathology (2011)
- AB of Pathology, Anatomic & Clinical Pathology (2011)
- Jiao J, Tang H, Sun N, Zhang X. Artificial intelligence–aided steatosis assessment in donor livers according to the Banff consensus recommendations. American Journal Of Clinical Pathology 2024, aqae053. PMID: 38716796, DOI: 10.1093/ajcp/aqae053.
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