Thomas Fernandez, MD
Child and Adolescent Psychiatry
Titles
- Associate Professor In the Child Study Center and in Psychiatry
- Vice Chair for Research, Child Study Center
- Co-Director of the Tic and OCD Program, Child Study Center
Education & Training
- FellowshipYale Child Study Center (2012)
- ResidencyYale-New Haven Hospital (2011)
- ResidencyYale-New Haven Hospital (2010)
- MDYale University School of Medicine (2005)
- BAPrinceton University, Psychology (1997)
Additional Information
Honors & Recognitions
- Allison Family Foundation Psychiatric Research Scholar: Yale Department of Psychiatry and Child Study Center (2012)
- Campaign for America’s Kids/ AACAP Annual Meeting Junior Scholar Award: American Academy of Child & Adolescent Psychiatry (2011)
- Travel Award: American College of Neuropsychopharmacology (2011)
- National Research Service Award (NRSA) T32 Research Training Grant: National Institute of Mental Health (2010)
- Seymour L. Lustman Award for Psychiatric Research: Yale University Department of Psychiatry (2010)
- Pilot Research Award for Junior Faculty and Child Psychiatry Fellows (“Genetic Investigation of Childhood Movement Disorders”) : American Academy of Child and Adolescent Psychiatry (2008)
- NIH Pediatric Loan Repayment Program: (2007), (2017)
Professional Service
- NIH Center for Scientific Review (2018 - Present): Behavioral Genetics and Epidemiology Study Section (BGES) Member
- American College of Neuropsychopharmacology (2018 - Present): Program Committee
- Yale University School of Medicine Dean's Faculty Advisory Council (2018 - Present): Member
- American Academy of Child and Adolescent Psychiatry (2017 - Present): Program Committee
- NIH Center for Scientific Review (2017 - 2018): Early Career Reviewer Program
- American College of Neuropsychopharmacology (2016 - Present): Associate Member
- International College of Neuropsychopharmacology (2016 - Present): Member
- Yale University School of Medicine Admissions Committee (2016 - Present): Committee Member
- American Society of Human Genetics (2015 - Present): Member
- American Academy of Child and Adolescent Psychiatry (2008 - Present): Member
Publications
- Please see CV for full listing of publications
- Wang S, Mandell JD, Kumar Y, Sun N, Morris MT, Arbelaez J, Nasello C, Dong S, Duhn C, Zhao X, Yang Z, Padmanabhuni SS, Yu D, King RA, Dietrich A, Khalifa N, Dahl N, Huang AY, Neale BM, Coppola G, Mathews CA, Scharf JM, Fernandez TV, Buxbaum JD, De Rubeis S, Grice DE, Xing J, Heiman GA, Tischfield JA, Paschou P, Willsey AJ, State MW. De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis. Cell Reports 2018, 24: 3441-3454.e12. PMID: 30257206, PMCID: PMC6475626, DOI: 10.1016/j.celrep.2018.08.082.
- Willsey AJ, Fernandez TV, Yu D, King RA, Dietrich A, Xing J, Sanders SJ, Mandell JD, Huang AY, Richer P, Smith L, Dong S, Samocha KE, Neale BM, Coppola G, Mathews CA, Tischfield JA, Scharf JM, State MW, Heiman GA. De Novo Coding Variants Are Strongly Associated with Tourette Disorder. Neuron 2017, 94: 486-499.e9. PMID: 28472652, PMCID: PMC5769876, DOI: 10.1016/j.neuron.2017.04.024.
- Péter Z, Oliphant ME, Fernandez TV. Motor Stereotypies: A Pathophysiological Review. Frontiers In Neuroscience 2017, 11: 171. PMID: 28405185, PMCID: PMC5370241, DOI: 10.3389/fnins.2017.00171.
- Fernandez TV, Leckman JF. Prenatal and Perinatal Risk Factors and the Promise of Birth Cohort Studies: Origins of Obsessive-Compulsive Disorder. JAMA Psychiatry 2016, 73: 1117-1118. PMID: 27706471, PMCID: PMC5180419, DOI: 10.1001/jamapsychiatry.2016.2092.
- Leckman JF, Fernandez TV. The Origins of Tourette Syndrome: Prenatal Risk Factors and the Promise of Birth Cohort Studies. Journal Of The American Academy Of Child And Adolescent Psychiatry 2016, 55: 751-3. PMID: 27566115, PMCID: PMC5180440, DOI: 10.1016/j.jaac.2016.06.009.
- Cappi C, Brentani H, Lima L, Sanders SJ, Zai G, Diniz BJ, Reis VN, Hounie AG, Conceição do Rosário M, Mariani D, Requena GL, Puga R, Souza-Duran FL, Shavitt RG, Pauls DL, Miguel EC, Fernandez TV. Whole-exome sequencing in obsessive-compulsive disorder identifies rare mutations in immunological and neurodevelopmental pathways. Translational Psychiatry 2016, 6: e764. PMID: 27023170, PMCID: PMC4872454, DOI: 10.1038/tp.2016.30.
- Lennington JB, Coppola G, Kataoka-Sasaki Y, Fernandez TV, Palejev D, Li Y, Huttner A, Pletikos M, Sestan N, Leckman JF, Vaccarino FM. Transcriptome Analysis of the Human Striatum in Tourette Syndrome. Biological Psychiatry 2016, 79: 372-382. PMID: 25199956, PMCID: PMC4305353, DOI: 10.1016/j.biopsych.2014.07.018.
- Fernandez TV. What Makes You Tic? A New Lead in Tourette Syndrome Genetics. Biological Psychiatry 2016, 79: 341-342. PMID: 26847659, PMCID: PMC4758116, DOI: 10.1016/j.biopsych.2015.12.018.
- Richer P, Fernandez TV. Tourette Syndrome: Bridging the Gap between Genetics and Biology. Molecular Neuropsychiatry 2015, 1: 156-164. PMID: 26509143, PMCID: PMC4617782, DOI: 10.1159/000439085.
- Fernandez TV, King RA, Pittenger C. Tourette's syndrome and translational clinical science. Journal Of The American Academy Of Child And Adolescent Psychiatry 2015, 54: 6-8. PMID: 25524784, PMCID: PMC4502583, DOI: 10.1016/j.jaac.2014.11.004.
- Scharf JM, Yu D, Mathews CA, Neale BM, Stewart SE, Fagerness JA, Evans P, Gamazon E, Edlund CK, Service SK, Tikhomirov A, Osiecki L, Illmann C, Pluzhnikov A, Konkashbaev A, Davis LK, Han B, Crane J, Moorjani P, Crenshaw AT, Parkin MA, Reus VI, Lowe TL, Rangel-Lugo M, Chouinard S, Dion Y, Girard S, Cath DC, Smit JH, King RA, Fernandez TV, Leckman JF, Kidd KK, Kidd JR, Pakstis AJ, State MW, Herrera LD, Romero R, Fournier E, Sandor P, Barr CL, Phan N, Gross-Tsur V, Benarroch F, Pollak Y, Budman CL, Bruun RD, Erenberg G, Naarden AL, Lee PC, Weiss N, Kremeyer B, Berrío GB, Campbell DD, Cardona Silgado JC, Ochoa WC, Mesa Restrepo SC, Muller H, Valencia Duarte AV, Lyon GJ, Leppert M, Morgan J, Weiss R, Grados MA, Anderson K, Davarya S, Singer H, Walkup J, Jankovic J, Tischfield JA, Heiman GA, Gilbert DL, Hoekstra PJ, Robertson MM, Kurlan R, Liu C, Gibbs JR, Singleton A, Hardy J, Strengman E, Ophoff RA, Wagner M, Moessner R, Mirel DB, Posthuma D, Sabatti C, Eskin E, Conti DV, Knowles JA, Ruiz-Linares A, Rouleau GA, Purcell S, Heutink P, Oostra BA, McMahon WM, Freimer NB, Cox NJ, Pauls DL. Genome-wide association study of Tourette's syndrome. Molecular Psychiatry 2013, 18: 721-8. PMID: 22889924, PMCID: PMC3605224, DOI: 10.1038/mp.2012.69.
- Fernandez TV, Sanders SJ, Yurkiewicz IR, Ercan-Sencicek AG, Kim YS, Fishman DO, Raubeson MJ, Song Y, Yasuno K, Ho WS, Bilguvar K, Glessner J, Chu SH, Leckman JF, King RA, Gilbert DL, Heiman GA, Tischfield JA, Hoekstra PJ, Devlin B, Hakonarson H, Mane SM, Günel M, State MW. Rare copy number variants in tourette syndrome disrupt genes in histaminergic pathways and overlap with autism. Biological Psychiatry 2012, 71: 392-402. PMID: 22169095, PMCID: PMC3282144, DOI: 10.1016/j.biopsych.2011.09.034.
- Sanders SJ, Ercan-Sencicek AG, Hus V, Luo R, Murtha MT, Moreno-De-Luca D, Chu SH, Moreau MP, Gupta AR, Thomson SA, Mason CE, Bilguvar K, Celestino-Soper PB, Choi M, Crawford EL, Davis L, Wright NR, Dhodapkar RM, DiCola M, DiLullo NM, Fernandez TV, Fielding-Singh V, Fishman DO, Frahm S, Garagaloyan R, Goh GS, Kammela S, Klei L, Lowe JK, Lund SC, McGrew AD, Meyer KA, Moffat WJ, Murdoch JD, O'Roak BJ, Ober GT, Pottenger RS, Raubeson MJ, Song Y, Wang Q, Yaspan BL, Yu TW, Yurkiewicz IR, Beaudet AL, Cantor RM, Curland M, Grice DE, Günel M, Lifton RP, Mane SM, Martin DM, Shaw CA, Sheldon M, Tischfield JA, Walsh CA, Morrow EM, Ledbetter DH, Fombonne E, Lord C, Martin CL, Brooks AI, Sutcliffe JS, Cook EH, Geschwind D, Roeder K, Devlin B, State MW. Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism. Neuron 2011, 70: 863-85. PMID: 21658581, PMCID: PMC3939065, DOI: 10.1016/j.neuron.2011.05.002.
- Ercan-Sencicek AG, Stillman AA, Ghosh AK, Bilguvar K, O'Roak BJ, Mason CE, Abbott T, Gupta A, King RA, Pauls DL, Tischfield JA, Heiman GA, Singer HS, Gilbert DL, Hoekstra PJ, Morgan TM, Loring E, Yasuno K, Fernandez T, Sanders S, Louvi A, Cho JH, Mane S, Colangelo CM, Biederer T, Lifton RP, Gunel M, State MW. L-histidine decarboxylase and Tourette's syndrome. The New England Journal Of Medicine 2010, 362: 1901-8. PMID: 20445167, PMCID: PMC2894694, DOI: 10.1056/NEJMoa0907006.
Patient Care Organizations
Titles
- Associate Professor In the Child Study Center and in Psychiatry
- Vice Chair for Research, Child Study Center
- Co-Director of the Tic and OCD Program, Child Study Center
Education & Training
- FellowshipYale Child Study Center (2012)
- ResidencyYale-New Haven Hospital (2011)
- ResidencyYale-New Haven Hospital (2010)
- MDYale University School of Medicine (2005)
- BAPrinceton University, Psychology (1997)
Additional Information
Honors & Recognitions
- Allison Family Foundation Psychiatric Research Scholar: Yale Department of Psychiatry and Child Study Center (2012)
- Campaign for America’s Kids/ AACAP Annual Meeting Junior Scholar Award: American Academy of Child & Adolescent Psychiatry (2011)
- Travel Award: American College of Neuropsychopharmacology (2011)
- National Research Service Award (NRSA) T32 Research Training Grant: National Institute of Mental Health (2010)
- Seymour L. Lustman Award for Psychiatric Research: Yale University Department of Psychiatry (2010)
- Pilot Research Award for Junior Faculty and Child Psychiatry Fellows (“Genetic Investigation of Childhood Movement Disorders”) : American Academy of Child and Adolescent Psychiatry (2008)
- NIH Pediatric Loan Repayment Program: (2007), (2017)
Professional Service
- NIH Center for Scientific Review (2018 - Present): Behavioral Genetics and Epidemiology Study Section (BGES) Member
- American College of Neuropsychopharmacology (2018 - Present): Program Committee
- Yale University School of Medicine Dean's Faculty Advisory Council (2018 - Present): Member
- American Academy of Child and Adolescent Psychiatry (2017 - Present): Program Committee
- NIH Center for Scientific Review (2017 - 2018): Early Career Reviewer Program
- American College of Neuropsychopharmacology (2016 - Present): Associate Member
- International College of Neuropsychopharmacology (2016 - Present): Member
- Yale University School of Medicine Admissions Committee (2016 - Present): Committee Member
- American Society of Human Genetics (2015 - Present): Member
- American Academy of Child and Adolescent Psychiatry (2008 - Present): Member
Publications
- Please see CV for full listing of publications
- Wang S, Mandell JD, Kumar Y, Sun N, Morris MT, Arbelaez J, Nasello C, Dong S, Duhn C, Zhao X, Yang Z, Padmanabhuni SS, Yu D, King RA, Dietrich A, Khalifa N, Dahl N, Huang AY, Neale BM, Coppola G, Mathews CA, Scharf JM, Fernandez TV, Buxbaum JD, De Rubeis S, Grice DE, Xing J, Heiman GA, Tischfield JA, Paschou P, Willsey AJ, State MW. De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis. Cell Reports 2018, 24: 3441-3454.e12. PMID: 30257206, PMCID: PMC6475626, DOI: 10.1016/j.celrep.2018.08.082.
- Willsey AJ, Fernandez TV, Yu D, King RA, Dietrich A, Xing J, Sanders SJ, Mandell JD, Huang AY, Richer P, Smith L, Dong S, Samocha KE, Neale BM, Coppola G, Mathews CA, Tischfield JA, Scharf JM, State MW, Heiman GA. De Novo Coding Variants Are Strongly Associated with Tourette Disorder. Neuron 2017, 94: 486-499.e9. PMID: 28472652, PMCID: PMC5769876, DOI: 10.1016/j.neuron.2017.04.024.
- Péter Z, Oliphant ME, Fernandez TV. Motor Stereotypies: A Pathophysiological Review. Frontiers In Neuroscience 2017, 11: 171. PMID: 28405185, PMCID: PMC5370241, DOI: 10.3389/fnins.2017.00171.
- Fernandez TV, Leckman JF. Prenatal and Perinatal Risk Factors and the Promise of Birth Cohort Studies: Origins of Obsessive-Compulsive Disorder. JAMA Psychiatry 2016, 73: 1117-1118. PMID: 27706471, PMCID: PMC5180419, DOI: 10.1001/jamapsychiatry.2016.2092.
- Leckman JF, Fernandez TV. The Origins of Tourette Syndrome: Prenatal Risk Factors and the Promise of Birth Cohort Studies. Journal Of The American Academy Of Child And Adolescent Psychiatry 2016, 55: 751-3. PMID: 27566115, PMCID: PMC5180440, DOI: 10.1016/j.jaac.2016.06.009.
- Cappi C, Brentani H, Lima L, Sanders SJ, Zai G, Diniz BJ, Reis VN, Hounie AG, Conceição do Rosário M, Mariani D, Requena GL, Puga R, Souza-Duran FL, Shavitt RG, Pauls DL, Miguel EC, Fernandez TV. Whole-exome sequencing in obsessive-compulsive disorder identifies rare mutations in immunological and neurodevelopmental pathways. Translational Psychiatry 2016, 6: e764. PMID: 27023170, PMCID: PMC4872454, DOI: 10.1038/tp.2016.30.
- Lennington JB, Coppola G, Kataoka-Sasaki Y, Fernandez TV, Palejev D, Li Y, Huttner A, Pletikos M, Sestan N, Leckman JF, Vaccarino FM. Transcriptome Analysis of the Human Striatum in Tourette Syndrome. Biological Psychiatry 2016, 79: 372-382. PMID: 25199956, PMCID: PMC4305353, DOI: 10.1016/j.biopsych.2014.07.018.
- Fernandez TV. What Makes You Tic? A New Lead in Tourette Syndrome Genetics. Biological Psychiatry 2016, 79: 341-342. PMID: 26847659, PMCID: PMC4758116, DOI: 10.1016/j.biopsych.2015.12.018.
- Richer P, Fernandez TV. Tourette Syndrome: Bridging the Gap between Genetics and Biology. Molecular Neuropsychiatry 2015, 1: 156-164. PMID: 26509143, PMCID: PMC4617782, DOI: 10.1159/000439085.
- Fernandez TV, King RA, Pittenger C. Tourette's syndrome and translational clinical science. Journal Of The American Academy Of Child And Adolescent Psychiatry 2015, 54: 6-8. PMID: 25524784, PMCID: PMC4502583, DOI: 10.1016/j.jaac.2014.11.004.
- Scharf JM, Yu D, Mathews CA, Neale BM, Stewart SE, Fagerness JA, Evans P, Gamazon E, Edlund CK, Service SK, Tikhomirov A, Osiecki L, Illmann C, Pluzhnikov A, Konkashbaev A, Davis LK, Han B, Crane J, Moorjani P, Crenshaw AT, Parkin MA, Reus VI, Lowe TL, Rangel-Lugo M, Chouinard S, Dion Y, Girard S, Cath DC, Smit JH, King RA, Fernandez TV, Leckman JF, Kidd KK, Kidd JR, Pakstis AJ, State MW, Herrera LD, Romero R, Fournier E, Sandor P, Barr CL, Phan N, Gross-Tsur V, Benarroch F, Pollak Y, Budman CL, Bruun RD, Erenberg G, Naarden AL, Lee PC, Weiss N, Kremeyer B, Berrío GB, Campbell DD, Cardona Silgado JC, Ochoa WC, Mesa Restrepo SC, Muller H, Valencia Duarte AV, Lyon GJ, Leppert M, Morgan J, Weiss R, Grados MA, Anderson K, Davarya S, Singer H, Walkup J, Jankovic J, Tischfield JA, Heiman GA, Gilbert DL, Hoekstra PJ, Robertson MM, Kurlan R, Liu C, Gibbs JR, Singleton A, Hardy J, Strengman E, Ophoff RA, Wagner M, Moessner R, Mirel DB, Posthuma D, Sabatti C, Eskin E, Conti DV, Knowles JA, Ruiz-Linares A, Rouleau GA, Purcell S, Heutink P, Oostra BA, McMahon WM, Freimer NB, Cox NJ, Pauls DL. Genome-wide association study of Tourette's syndrome. Molecular Psychiatry 2013, 18: 721-8. PMID: 22889924, PMCID: PMC3605224, DOI: 10.1038/mp.2012.69.
- Fernandez TV, Sanders SJ, Yurkiewicz IR, Ercan-Sencicek AG, Kim YS, Fishman DO, Raubeson MJ, Song Y, Yasuno K, Ho WS, Bilguvar K, Glessner J, Chu SH, Leckman JF, King RA, Gilbert DL, Heiman GA, Tischfield JA, Hoekstra PJ, Devlin B, Hakonarson H, Mane SM, Günel M, State MW. Rare copy number variants in tourette syndrome disrupt genes in histaminergic pathways and overlap with autism. Biological Psychiatry 2012, 71: 392-402. PMID: 22169095, PMCID: PMC3282144, DOI: 10.1016/j.biopsych.2011.09.034.
- Sanders SJ, Ercan-Sencicek AG, Hus V, Luo R, Murtha MT, Moreno-De-Luca D, Chu SH, Moreau MP, Gupta AR, Thomson SA, Mason CE, Bilguvar K, Celestino-Soper PB, Choi M, Crawford EL, Davis L, Wright NR, Dhodapkar RM, DiCola M, DiLullo NM, Fernandez TV, Fielding-Singh V, Fishman DO, Frahm S, Garagaloyan R, Goh GS, Kammela S, Klei L, Lowe JK, Lund SC, McGrew AD, Meyer KA, Moffat WJ, Murdoch JD, O'Roak BJ, Ober GT, Pottenger RS, Raubeson MJ, Song Y, Wang Q, Yaspan BL, Yu TW, Yurkiewicz IR, Beaudet AL, Cantor RM, Curland M, Grice DE, Günel M, Lifton RP, Mane SM, Martin DM, Shaw CA, Sheldon M, Tischfield JA, Walsh CA, Morrow EM, Ledbetter DH, Fombonne E, Lord C, Martin CL, Brooks AI, Sutcliffe JS, Cook EH, Geschwind D, Roeder K, Devlin B, State MW. Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism. Neuron 2011, 70: 863-85. PMID: 21658581, PMCID: PMC3939065, DOI: 10.1016/j.neuron.2011.05.002.
- Ercan-Sencicek AG, Stillman AA, Ghosh AK, Bilguvar K, O'Roak BJ, Mason CE, Abbott T, Gupta A, King RA, Pauls DL, Tischfield JA, Heiman GA, Singer HS, Gilbert DL, Hoekstra PJ, Morgan TM, Loring E, Yasuno K, Fernandez T, Sanders S, Louvi A, Cho JH, Mane S, Colangelo CM, Biederer T, Lifton RP, Gunel M, State MW. L-histidine decarboxylase and Tourette's syndrome. The New England Journal Of Medicine 2010, 362: 1901-8. PMID: 20445167, PMCID: PMC2894694, DOI: 10.1056/NEJMoa0907006.
Patient Care Organizations