- Yale PathologyYale New Haven Hospital20 York Street, Wing East Pavilion Fl 2ndNew Haven, CT 06510
Natalia Buza, MD
Biography
As a pathologist specializing in gynecologic and breast cancers and diseases, Natalia Buza, MD, rarely sees the patients she spends many hours thinking about; her work is done not in an exam room, but behind a high-powered microscope. This doesn’t make her patients any less real, however. Dr. Buza explains that she became a pathologist because “it’s an exciting discipline and so important for patient care.”
Working closely with gynecologic cancer doctors, Dr. Buza examines samples of patients’ tissue taken for a biopsy to look for signs of endometrial, ovarian and cervical cancers. Once a cancer has been identified, she continues her examination of the cells, specifying the tumor subtype and looking for specific markers at the protein and genetic level that could help the patient’s physician create a personalized cancer treatment plan. Also, she notes, “I do a lot of collaborative research and studies.” For example, she and other colleagues recently investigated the possibility of using targeted anti-HER2 therapy in certain endometrial cancers.
Dr. Buza is an associate professor of pathology and associate director of gynecologic pathology at Yale School of Medicine.
Titles
- Professor of Pathology
- Associate Director of Gynecologic Pathology
Education & Training
- FellowshipYale School of Medicine (2010)
- ResidencyYale University School of Medicine (2009)
- MDUniversity of Pecs Med and Health Science Center (1999)
Languages Spoken
- English
- Magyar (Hungarian)
Additional Information
- The Averill A. Liebow Award for Excellence in the Teaching of Pathology Residents: (2016)
- Modern Pathology (2021 - Present): Editorial Board Member
- Human Pathology (2018 - Present): Editorial Board Member
- International Journal of Gynecological Pathology (2016 - Present): Editorial Board Member
- Yadav G, Roque DM, Bellone S, Manavella DD, Hartwich TMP, Zipponi M, Harold J, Tymon-Rosario J, Mutlu L, Altwerger G, Menderes G, Ratner E, Buza N, Hui P, Huang GS, Andikyan V, Clark M, Azodi M, Schwartz PE, Alexandrov LB, Santin AD. Synergistic activity of neratinib in combination with olaparib in uterine serous carcinoma overexpressing HER2/neu. Gynecologic Oncology 2022, 166: 351-357. PMID: 35641325, DOI: 10.1016/j.ygyno.2022.05.021.
- Buza N, Hui P. Characteristics of HER2 Gene Amplification by Fluorescence In Situ Hybridization in Endometrial Serous Carcinoma. Archives Of Pathology & Laboratory Medicine 2022, 146: 0. PMID: 35687792, DOI: 10.5858/arpa.2021-0547-OA.
- Roque DM, Siegel ER, Buza N, Bellone S, Silasi DA, Huang GS, Andikyan V, Clark M, Azodi M, Schwartz PE, Rao GG, Reader JC, Hui P, Tymon-Rosario JR, Harold J, Mauricio D, Zeybek B, Menderes G, Altwerger G, Ratner E, Santin AD. Randomised phase II trial of weekly ixabepilone ± biweekly bevacizumab for platinum-resistant or refractory ovarian/fallopian tube/primary peritoneal cancer. British Journal Of Cancer 2022, 126: 1695-1703. PMID: 35149854, PMCID: PMC8853032, DOI: 10.1038/s41416-022-01717-6.
- Buza N. Gestational Trophoblastic Disease: Contemporary Diagnostic Approach. Surgical Pathology Clinics 2022, 15: 197-218. PMID: 35715158, DOI: 10.1016/j.path.2022.02.002.
- McHenry A, Buza N. Anastomosing Hemangioma of the Ovary With Leydig Cell Hyperplasia: A Clinicopathologic Study of 12 Cases. International Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists 2022 PMID: 35512214, DOI: 10.1097/PGP.0000000000000887.
- Bellone S, Roque DM, Siegel ER, Buza N, Hui P, Bonazzoli E, Guglielmi A, Zammataro L, Nagarkatti N, Zaidi S, Lee J, Silasi DA, Huang GS, Andikyan V, Damast S, Clark M, Azodi M, Schwartz PE, Tymon-Rosario JR, Harold JA, Mauricio D, Zeybek B, Menderes G, Altwerger G, Ratner E, Alexandrov LB, Iwasaki A, Kong Y, Song E, Dong W, Elvin JA, Choi J, Santin AD. A phase 2 evaluation of pembrolizumab for recurrent Lynch-like versus sporadic endometrial cancers with microsatellite instability. Cancer 2022, 128: 1206-1218. PMID: 34875107, DOI: 10.1002/cncr.34025.
- Cagaanan A, Stelter B, Vu N, Rhode EN, Stewart T, Hui P, Buza N, Al-Niaimi A, Flynn C, Weisman PS, McGregor SM. HER2 Expression in Endometrial Cancers Diagnosed as Clear Cell Carcinoma. International Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists 2022, 41: 132-141. PMID: 33782344, DOI: 10.1097/PGP.0000000000000783.
- Li JY, Mutlu L, Tymon-Rosario J, Khadraoui W, Nagarkatti N, Hui P, Buza N, Lu L, Schwartz P, Menderes G. Clinicopathologic characteristics and oncologic outcomes in adenosarcoma of gynecologic sites. Gynecologic Oncology Reports 2022, 39: 100913. PMID: 35005157, PMCID: PMC8715286, DOI: 10.1016/j.gore.2021.100913.
- Buza N. Immunohistochemistry in gynecologic carcinomas: Practical update with diagnostic and clinical considerations based on the 2020 WHO classification of tumors. Seminars In Diagnostic Pathology 2022, 39: 58-77. PMID: 34750021, DOI: 10.1053/j.semdp.2021.10.006.
- Assem H, Rottmann D, Finkelstein A, Wang M, Ratner E, Santin AD, Buza N, Hui P. Minimal uterine serous carcinoma and endometrial polyp: a close clinicopathological relationship. Human Pathology 2021, 118: 1-8. PMID: 34508766, DOI: 10.1016/j.humpath.2021.09.001.
- Tymon-Rosario J, Bonazzoli E, Bellone S, Manzano A, Pelligra S, Guglielmi A, Gnutti B, Nagarkatti N, Zeybek B, Manara P, Zammataro L, Harold J, Mauricio D, Buza N, Hui P, Altwerger G, Menderes G, Ratner E, Clark M, Andikyan V, Huang GS, Silasi DA, Azodi M, Schwartz PE, Santin AD. DHES0815A, a novel antibody-drug conjugate targeting HER2/neu, is highly active against uterine serous carcinomas in vitro and in vivo. Gynecologic Oncology 2021, 163: 334-341. PMID: 34452746, PMCID: PMC8722447, DOI: 10.1016/j.ygyno.2021.08.014.
- Buza N, Hui P. Genotyping diagnosis of gestational trophoblastic disease: frontiers in precision medicine. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2021, 34: 1658-1672. PMID: 34088998, DOI: 10.1038/s41379-021-00831-9.
- Bellone S, Roque DM, Siegel ER, Buza N, Hui P, Bonazzoli E, Guglielmi A, Zammataro L, Nagarkatti N, Zaidi S, Lee J, Silasi DA, Huang GS, Andikyan V, Damast S, Clark M, Azodi M, Schwartz PE, Tymon-Rosario J, Harold J, Mauricio D, Zeybek B, Menderes G, Altwerger G, Ratner E, Alexandrov LB, Iwasaki A, Kong Y, Song E, Dong W, Elvin J, Choi J, Santin AD. A phase II evaluation of pembrolizumab in recurrent microsatellite instability-high (MSI-H) endometrial cancer patients with Lynch-like versus MLH-1 methylated characteristics (NCT02899793). Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / ESMO 2021, 32: 1045-1046. PMID: 33932502, DOI: 10.1016/j.annonc.2021.04.013.
- Buza N. HER2 Testing in Endometrial Serous Carcinoma: Time for Standardized Pathology Practice to Meet the Clinical Demand. Archives Of Pathology & Laboratory Medicine 2021, 145: 687-691. PMID: 32649220, DOI: 10.5858/arpa.2020-0207-RA.
- Buza N, Euscher ED, Matias-Guiu X, McHenry A, Oliva E, Ordulu Z, Parra-Herran C, Rottmann D, Turner BM, Wong S, Hui P. Reproducibility of scoring criteria for HER2 immunohistochemistry in endometrial serous carcinoma: a multi-institutional interobserver agreement study. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2021, 34: 1194-1202. PMID: 33536574, DOI: 10.1038/s41379-021-00746-5.
- Rottmann D, Assem H, Matsumoto N, Wong S, Hui P, Buza N. Does Specimen Type Have an Impact on HER2 Status in Endometrial Serous Carcinoma? Discordant HER2 Status of Paired Endometrial Biopsy and Hysterectomy Specimens in the Presence of Frequent Intratumoral Heterogeneity. International Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists 2021, 40: 263-271. PMID: 32897955, DOI: 10.1097/PGP.0000000000000690.
- Choi J, Manzano A, Dong W, Bellone S, Bonazzoli E, Zammataro L, Yao X, Deshpande A, Zaidi S, Guglielmi A, Gnutti B, Nagarkatti N, Tymon-Rosario JR, Harold J, Mauricio D, Zeybek B, Menderes G, Altwerger G, Jeong K, Zhao S, Buza N, Hui P, Ravaggi A, Bignotti E, Romani C, Todeschini P, Zanotti L, Odicino F, Pecorelli S, Ardighieri L, Bilguvar K, Quick CM, Silasi DA, Huang GS, Andikyan V, Clark M, Ratner E, Azodi M, Imielinski M, Schwartz PE, Alexandrov LB, Lifton RP, Schlessinger J, Santin AD. Integrated mutational landscape analysis of uterine leiomyosarcomas. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118 PMID: 33876771, PMCID: PMC8053980, DOI: 10.1073/pnas.2025182118.
- Buza N. HER2 Testing and Reporting in Endometrial Serous Carcinoma: Practical Recommendations for HER2 Immunohistochemistry and Fluorescent In Situ Hybridization: Proceedings of the ISGyP Companion Society Session at the 2020 USCAP Annual Meeting. International Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists 2021, 40: 17-23. PMID: 33290351, DOI: 10.1097/PGP.0000000000000711.
- Erickson BK, Najjar O, Damast S, Blakaj A, Tymon-Rosario J, Shahi M, Santin A, Klein M, Dolan M, Cimino-Mathews A, Buza N, Ferriss JS, Stone RL, Khalifa M, Fader AN. Human epidermal growth factor 2 (HER2) in early stage uterine serous carcinoma: A multi-institutional cohort study. Gynecologic Oncology 2020, 159: 17-22. PMID: 32709539, PMCID: PMC7541557, DOI: 10.1016/j.ygyno.2020.07.016.
- Ordulu Z, Chai H, Peng G, McDonald AG, De Nictolis M, Garcia-Fernandez E, Hardisson D, Prat J, Li P, Hui P, Oliva E, Buza N. Molecular and clinicopathologic characterization of intravenous leiomyomatosis. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2020, 33: 1844-1860. PMID: 32341498, PMCID: PMC7483566, DOI: 10.1038/s41379-020-0546-8.
- Wong S, Hui P, Buza N. Frequent loss of mutation-specific mismatch repair protein expression in nonneoplastic endometrium of Lynch syndrome patients. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2020, 33: 1172-1181. PMID: 31932681, DOI: 10.1038/s41379-020-0455-x.
- Simpson S, Simoni M, Hui P, Taylor H, Buza N. Extragonadal Yolk Sac Tumor Limited to the Myometrium: Report of a Case With Potential Fertility Preservation and Molecular Analysis Suggesting Germ Cell Origin. International Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists 2020, 39: 247-253. PMID: 31033797, DOI: 10.1097/PGP.0000000000000601.
- Pelligra S, Buza N, Hui P, Bellone S, Zeybek B, Ratner E, Schwartz PE, Scambia G, Santin AD. Selection of HER2/NEU negative tumor cells as a mechanism of resistance to trastuzumab in uterine serous carcinoma. Gynecologic Oncology Reports 2020, 32: 100554. PMID: 32140533, PMCID: PMC7049633, DOI: 10.1016/j.gore.2020.100554.
- Santin AD, Deng W, Frumovitz M, Buza N, Bellone S, Huh W, Khleif S, Lankes HA, Ratner ES, O'Cearbhaill RE, Jazaeri AA, Birrer M. Phase II evaluation of nivolumab in the treatment of persistent or recurrent cervical cancer (NCT02257528/NRG-GY002). Gynecologic Oncology 2020, 157: 161-166. PMID: 31924334, PMCID: PMC7127981, DOI: 10.1016/j.ygyno.2019.12.034.
- Chen PH, Hui P, Buza N. Bilateral Signet-ring Stromal Tumor of the Ovary: A Case Report With Next-generation Sequencing Analysis and FOXL2 Mutation Testing. International Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists 2020, 39: 193-198. PMID: 30676431, DOI: 10.1097/PGP.0000000000000579.
- Rottmann D, Snir OL, Wu X, Wong S, Hui P, Santin AD, Buza N. HER2 testing of gynecologic carcinosarcomas: tumor stratification for potential targeted therapy. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2020, 33: 118-127. PMID: 31477811, DOI: 10.1038/s41379-019-0358-x.
- Zammataro L, Lopez S, Bellone S, Pettinella F, Bonazzoli E, Perrone E, Zhao S, Menderes G, Altwerger G, Han C, Zeybek B, Bianchi A, Manzano A, Manara P, Cocco E, Buza N, Hui P, Wong S, Ravaggi A, Bignotti E, Romani C, Todeschini P, Zanotti L, Odicino F, Pecorelli S, Donzelli C, Ardighieri L, Angioli R, Raspagliesi F, Scambia G, Choi J, Dong W, Bilguvar K, Alexandrov LB, Silasi DA, Huang GS, Ratner E, Azodi M, Schwartz PE, Pirazzoli V, Stiegler AL, Boggon TJ, Lifton RP, Schlessinger J, Santin AD. Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 22730-22736. PMID: 31624127, PMCID: PMC6842590, DOI: 10.1073/pnas.1911385116.
- Buza N, Baine I, Hui P. Precision genotyping diagnosis of lung tumors with trophoblastic morphology in young women. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2019, 32: 1271-1280. PMID: 31028360, DOI: 10.1038/s41379-019-0275-z.
- Nolan A, Buza N, Margeta M, Rabban JT. Ovarian Teratomas in Women With Anti-N-methyl-D-Aspartate Receptor Encephalitis: Topography and Composition of Immune Cell and Neuroglial Populations Is Compatible With an Autoimmune Mechanism of Disease. The American Journal Of Surgical Pathology 2019, 43: 949-964. PMID: 31021857, DOI: 10.1097/PAS.0000000000001249.
- Buza N, McGregor SM, Barroilhet L, Zheng X, Hui P. Paternal uniparental isodisomy of tyrosine hydroxylase locus at chromosome 11p15.4: spectrum of phenotypical presentations simulating hydatidiform moles. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2019, 32: 1180-1188. PMID: 30952972, DOI: 10.1038/s41379-019-0266-0.
- Wu X, Snir O, Rottmann D, Wong S, Buza N, Hui P. Minimal microsatellite shift in microsatellite instability high endometrial cancer: a significant pitfall in diagnostic interpretation. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2019, 32: 650-658. PMID: 30443012, DOI: 10.1038/s41379-018-0179-3.
- Buza N. Frozen Section Diagnosis of Ovarian Epithelial Tumors: Diagnostic Pearls and Pitfalls. Archives Of Pathology & Laboratory Medicine 2019, 143: 47-64. PMID: 30785337, DOI: 10.5858/arpa.2018-0289-RA.
- Wong S, Ratner E, Buza N. Intra-operative evaluation of prophylactic hysterectomy and salpingo-oophorectomy specimens in hereditary gynaecological cancer syndromes. Histopathology 2018, 73: 109-123. PMID: 29484698, DOI: 10.1111/his.13503.
- Wong S, Hong W, Hui P, Buza N. Comprehensive Analysis of PAX8 Expression in Epithelial Malignancies of the Uterine Cervix. International Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists 2017, 36: 101-106. PMID: 27362905, DOI: 10.1097/PGP.0000000000000309.
- Buza N, Ziai J, Hui P. Mismatch repair deficiency testing in clinical practice. Expert Review Of Molecular Diagnostics 2016, 16: 591-604. PMID: 26895074, DOI: 10.1586/14737159.2016.1156533.
- Hong W, Abi-Raad R, Alomari AK, Hui P, Buza N. Diagnostic application of KRAS mutation testing in uterine microglandular proliferations. Human Pathology 2015, 46: 1000-5. PMID: 25997988, DOI: 10.1016/j.humpath.2015.03.010.
- Carr RJ, Hui P, Buza N. Intravenous leiomyomatosis revisited: an experience of 14 cases at a single medical center. International Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists 2015, 34: 169-76. PMID: 25675187, DOI: 10.1097/PGP.0000000000000127.
- Buza N, Xu F, Wu W, Carr RJ, Li P, Hui P. Recurrent chromosomal aberrations in intravenous leiomyomatosis of the uterus: high-resolution array comparative genomic hybridization study. Human Pathology 2014, 45: 1885-92. PMID: 25033729, DOI: 10.1016/j.humpath.2014.05.010.
- Abi-Raad R, Alomari A, Hui P, Buza N. Mitotically active microglandular hyperplasia of the cervix: a case series with implications for the differential diagnosis. International Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists 2014, 33: 524-30. PMID: 25083971, DOI: 10.1097/PGP.0000000000000086.
- Buza N, Roque DM, Santin AD. HER2/neu in Endometrial Cancer: A Promising Therapeutic Target With Diagnostic Challenges. Archives Of Pathology & Laboratory Medicine 2014, 138: 343-50. PMID: 24576030, DOI: 10.5858/arpa.2012-0416-RA.
- Buza N, Rutherford T, Hui P. Genotyping diagnosis of nongestational choriocarcinoma involving fallopian tube and broad ligament: a case study. International Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists 2014, 33: 58-63. PMID: 24300537, DOI: 10.1097/PGP.0b013e31827cd386.
- Yale PathologyYale New Haven Hospital20 York Street, Wing East Pavilion Fl 2ndNew Haven, CT 06510
Biography
As a pathologist specializing in gynecologic and breast cancers and diseases, Natalia Buza, MD, rarely sees the patients she spends many hours thinking about; her work is done not in an exam room, but behind a high-powered microscope. This doesn’t make her patients any less real, however. Dr. Buza explains that she became a pathologist because “it’s an exciting discipline and so important for patient care.”
Working closely with gynecologic cancer doctors, Dr. Buza examines samples of patients’ tissue taken for a biopsy to look for signs of endometrial, ovarian and cervical cancers. Once a cancer has been identified, she continues her examination of the cells, specifying the tumor subtype and looking for specific markers at the protein and genetic level that could help the patient’s physician create a personalized cancer treatment plan. Also, she notes, “I do a lot of collaborative research and studies.” For example, she and other colleagues recently investigated the possibility of using targeted anti-HER2 therapy in certain endometrial cancers.
Dr. Buza is an associate professor of pathology and associate director of gynecologic pathology at Yale School of Medicine.
Titles
- Professor of Pathology
- Associate Director of Gynecologic Pathology
Education & Training
- FellowshipYale School of Medicine (2010)
- ResidencyYale University School of Medicine (2009)
- MDUniversity of Pecs Med and Health Science Center (1999)
Languages Spoken
- English
- Magyar (Hungarian)
Additional Information
- The Averill A. Liebow Award for Excellence in the Teaching of Pathology Residents: (2016)
- Modern Pathology (2021 - Present): Editorial Board Member
- Human Pathology (2018 - Present): Editorial Board Member
- International Journal of Gynecological Pathology (2016 - Present): Editorial Board Member
- Yadav G, Roque DM, Bellone S, Manavella DD, Hartwich TMP, Zipponi M, Harold J, Tymon-Rosario J, Mutlu L, Altwerger G, Menderes G, Ratner E, Buza N, Hui P, Huang GS, Andikyan V, Clark M, Azodi M, Schwartz PE, Alexandrov LB, Santin AD. Synergistic activity of neratinib in combination with olaparib in uterine serous carcinoma overexpressing HER2/neu. Gynecologic Oncology 2022, 166: 351-357. PMID: 35641325, DOI: 10.1016/j.ygyno.2022.05.021.
- Buza N, Hui P. Characteristics of HER2 Gene Amplification by Fluorescence In Situ Hybridization in Endometrial Serous Carcinoma. Archives Of Pathology & Laboratory Medicine 2022, 146: 0. PMID: 35687792, DOI: 10.5858/arpa.2021-0547-OA.
- Roque DM, Siegel ER, Buza N, Bellone S, Silasi DA, Huang GS, Andikyan V, Clark M, Azodi M, Schwartz PE, Rao GG, Reader JC, Hui P, Tymon-Rosario JR, Harold J, Mauricio D, Zeybek B, Menderes G, Altwerger G, Ratner E, Santin AD. Randomised phase II trial of weekly ixabepilone ± biweekly bevacizumab for platinum-resistant or refractory ovarian/fallopian tube/primary peritoneal cancer. British Journal Of Cancer 2022, 126: 1695-1703. PMID: 35149854, PMCID: PMC8853032, DOI: 10.1038/s41416-022-01717-6.
- Buza N. Gestational Trophoblastic Disease: Contemporary Diagnostic Approach. Surgical Pathology Clinics 2022, 15: 197-218. PMID: 35715158, DOI: 10.1016/j.path.2022.02.002.
- McHenry A, Buza N. Anastomosing Hemangioma of the Ovary With Leydig Cell Hyperplasia: A Clinicopathologic Study of 12 Cases. International Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists 2022 PMID: 35512214, DOI: 10.1097/PGP.0000000000000887.
- Bellone S, Roque DM, Siegel ER, Buza N, Hui P, Bonazzoli E, Guglielmi A, Zammataro L, Nagarkatti N, Zaidi S, Lee J, Silasi DA, Huang GS, Andikyan V, Damast S, Clark M, Azodi M, Schwartz PE, Tymon-Rosario JR, Harold JA, Mauricio D, Zeybek B, Menderes G, Altwerger G, Ratner E, Alexandrov LB, Iwasaki A, Kong Y, Song E, Dong W, Elvin JA, Choi J, Santin AD. A phase 2 evaluation of pembrolizumab for recurrent Lynch-like versus sporadic endometrial cancers with microsatellite instability. Cancer 2022, 128: 1206-1218. PMID: 34875107, DOI: 10.1002/cncr.34025.
- Cagaanan A, Stelter B, Vu N, Rhode EN, Stewart T, Hui P, Buza N, Al-Niaimi A, Flynn C, Weisman PS, McGregor SM. HER2 Expression in Endometrial Cancers Diagnosed as Clear Cell Carcinoma. International Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists 2022, 41: 132-141. PMID: 33782344, DOI: 10.1097/PGP.0000000000000783.
- Li JY, Mutlu L, Tymon-Rosario J, Khadraoui W, Nagarkatti N, Hui P, Buza N, Lu L, Schwartz P, Menderes G. Clinicopathologic characteristics and oncologic outcomes in adenosarcoma of gynecologic sites. Gynecologic Oncology Reports 2022, 39: 100913. PMID: 35005157, PMCID: PMC8715286, DOI: 10.1016/j.gore.2021.100913.
- Buza N. Immunohistochemistry in gynecologic carcinomas: Practical update with diagnostic and clinical considerations based on the 2020 WHO classification of tumors. Seminars In Diagnostic Pathology 2022, 39: 58-77. PMID: 34750021, DOI: 10.1053/j.semdp.2021.10.006.
- Assem H, Rottmann D, Finkelstein A, Wang M, Ratner E, Santin AD, Buza N, Hui P. Minimal uterine serous carcinoma and endometrial polyp: a close clinicopathological relationship. Human Pathology 2021, 118: 1-8. PMID: 34508766, DOI: 10.1016/j.humpath.2021.09.001.
- Tymon-Rosario J, Bonazzoli E, Bellone S, Manzano A, Pelligra S, Guglielmi A, Gnutti B, Nagarkatti N, Zeybek B, Manara P, Zammataro L, Harold J, Mauricio D, Buza N, Hui P, Altwerger G, Menderes G, Ratner E, Clark M, Andikyan V, Huang GS, Silasi DA, Azodi M, Schwartz PE, Santin AD. DHES0815A, a novel antibody-drug conjugate targeting HER2/neu, is highly active against uterine serous carcinomas in vitro and in vivo. Gynecologic Oncology 2021, 163: 334-341. PMID: 34452746, PMCID: PMC8722447, DOI: 10.1016/j.ygyno.2021.08.014.
- Buza N, Hui P. Genotyping diagnosis of gestational trophoblastic disease: frontiers in precision medicine. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2021, 34: 1658-1672. PMID: 34088998, DOI: 10.1038/s41379-021-00831-9.
- Bellone S, Roque DM, Siegel ER, Buza N, Hui P, Bonazzoli E, Guglielmi A, Zammataro L, Nagarkatti N, Zaidi S, Lee J, Silasi DA, Huang GS, Andikyan V, Damast S, Clark M, Azodi M, Schwartz PE, Tymon-Rosario J, Harold J, Mauricio D, Zeybek B, Menderes G, Altwerger G, Ratner E, Alexandrov LB, Iwasaki A, Kong Y, Song E, Dong W, Elvin J, Choi J, Santin AD. A phase II evaluation of pembrolizumab in recurrent microsatellite instability-high (MSI-H) endometrial cancer patients with Lynch-like versus MLH-1 methylated characteristics (NCT02899793). Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / ESMO 2021, 32: 1045-1046. PMID: 33932502, DOI: 10.1016/j.annonc.2021.04.013.
- Buza N. HER2 Testing in Endometrial Serous Carcinoma: Time for Standardized Pathology Practice to Meet the Clinical Demand. Archives Of Pathology & Laboratory Medicine 2021, 145: 687-691. PMID: 32649220, DOI: 10.5858/arpa.2020-0207-RA.
- Buza N, Euscher ED, Matias-Guiu X, McHenry A, Oliva E, Ordulu Z, Parra-Herran C, Rottmann D, Turner BM, Wong S, Hui P. Reproducibility of scoring criteria for HER2 immunohistochemistry in endometrial serous carcinoma: a multi-institutional interobserver agreement study. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2021, 34: 1194-1202. PMID: 33536574, DOI: 10.1038/s41379-021-00746-5.
- Rottmann D, Assem H, Matsumoto N, Wong S, Hui P, Buza N. Does Specimen Type Have an Impact on HER2 Status in Endometrial Serous Carcinoma? Discordant HER2 Status of Paired Endometrial Biopsy and Hysterectomy Specimens in the Presence of Frequent Intratumoral Heterogeneity. International Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists 2021, 40: 263-271. PMID: 32897955, DOI: 10.1097/PGP.0000000000000690.
- Choi J, Manzano A, Dong W, Bellone S, Bonazzoli E, Zammataro L, Yao X, Deshpande A, Zaidi S, Guglielmi A, Gnutti B, Nagarkatti N, Tymon-Rosario JR, Harold J, Mauricio D, Zeybek B, Menderes G, Altwerger G, Jeong K, Zhao S, Buza N, Hui P, Ravaggi A, Bignotti E, Romani C, Todeschini P, Zanotti L, Odicino F, Pecorelli S, Ardighieri L, Bilguvar K, Quick CM, Silasi DA, Huang GS, Andikyan V, Clark M, Ratner E, Azodi M, Imielinski M, Schwartz PE, Alexandrov LB, Lifton RP, Schlessinger J, Santin AD. Integrated mutational landscape analysis of uterine leiomyosarcomas. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118 PMID: 33876771, PMCID: PMC8053980, DOI: 10.1073/pnas.2025182118.
- Buza N. HER2 Testing and Reporting in Endometrial Serous Carcinoma: Practical Recommendations for HER2 Immunohistochemistry and Fluorescent In Situ Hybridization: Proceedings of the ISGyP Companion Society Session at the 2020 USCAP Annual Meeting. International Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists 2021, 40: 17-23. PMID: 33290351, DOI: 10.1097/PGP.0000000000000711.
- Erickson BK, Najjar O, Damast S, Blakaj A, Tymon-Rosario J, Shahi M, Santin A, Klein M, Dolan M, Cimino-Mathews A, Buza N, Ferriss JS, Stone RL, Khalifa M, Fader AN. Human epidermal growth factor 2 (HER2) in early stage uterine serous carcinoma: A multi-institutional cohort study. Gynecologic Oncology 2020, 159: 17-22. PMID: 32709539, PMCID: PMC7541557, DOI: 10.1016/j.ygyno.2020.07.016.
- Ordulu Z, Chai H, Peng G, McDonald AG, De Nictolis M, Garcia-Fernandez E, Hardisson D, Prat J, Li P, Hui P, Oliva E, Buza N. Molecular and clinicopathologic characterization of intravenous leiomyomatosis. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2020, 33: 1844-1860. PMID: 32341498, PMCID: PMC7483566, DOI: 10.1038/s41379-020-0546-8.
- Wong S, Hui P, Buza N. Frequent loss of mutation-specific mismatch repair protein expression in nonneoplastic endometrium of Lynch syndrome patients. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2020, 33: 1172-1181. PMID: 31932681, DOI: 10.1038/s41379-020-0455-x.
- Simpson S, Simoni M, Hui P, Taylor H, Buza N. Extragonadal Yolk Sac Tumor Limited to the Myometrium: Report of a Case With Potential Fertility Preservation and Molecular Analysis Suggesting Germ Cell Origin. International Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists 2020, 39: 247-253. PMID: 31033797, DOI: 10.1097/PGP.0000000000000601.
- Pelligra S, Buza N, Hui P, Bellone S, Zeybek B, Ratner E, Schwartz PE, Scambia G, Santin AD. Selection of HER2/NEU negative tumor cells as a mechanism of resistance to trastuzumab in uterine serous carcinoma. Gynecologic Oncology Reports 2020, 32: 100554. PMID: 32140533, PMCID: PMC7049633, DOI: 10.1016/j.gore.2020.100554.
- Santin AD, Deng W, Frumovitz M, Buza N, Bellone S, Huh W, Khleif S, Lankes HA, Ratner ES, O'Cearbhaill RE, Jazaeri AA, Birrer M. Phase II evaluation of nivolumab in the treatment of persistent or recurrent cervical cancer (NCT02257528/NRG-GY002). Gynecologic Oncology 2020, 157: 161-166. PMID: 31924334, PMCID: PMC7127981, DOI: 10.1016/j.ygyno.2019.12.034.
- Chen PH, Hui P, Buza N. Bilateral Signet-ring Stromal Tumor of the Ovary: A Case Report With Next-generation Sequencing Analysis and FOXL2 Mutation Testing. International Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists 2020, 39: 193-198. PMID: 30676431, DOI: 10.1097/PGP.0000000000000579.
- Rottmann D, Snir OL, Wu X, Wong S, Hui P, Santin AD, Buza N. HER2 testing of gynecologic carcinosarcomas: tumor stratification for potential targeted therapy. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2020, 33: 118-127. PMID: 31477811, DOI: 10.1038/s41379-019-0358-x.
- Zammataro L, Lopez S, Bellone S, Pettinella F, Bonazzoli E, Perrone E, Zhao S, Menderes G, Altwerger G, Han C, Zeybek B, Bianchi A, Manzano A, Manara P, Cocco E, Buza N, Hui P, Wong S, Ravaggi A, Bignotti E, Romani C, Todeschini P, Zanotti L, Odicino F, Pecorelli S, Donzelli C, Ardighieri L, Angioli R, Raspagliesi F, Scambia G, Choi J, Dong W, Bilguvar K, Alexandrov LB, Silasi DA, Huang GS, Ratner E, Azodi M, Schwartz PE, Pirazzoli V, Stiegler AL, Boggon TJ, Lifton RP, Schlessinger J, Santin AD. Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 22730-22736. PMID: 31624127, PMCID: PMC6842590, DOI: 10.1073/pnas.1911385116.
- Buza N, Baine I, Hui P. Precision genotyping diagnosis of lung tumors with trophoblastic morphology in young women. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2019, 32: 1271-1280. PMID: 31028360, DOI: 10.1038/s41379-019-0275-z.
- Nolan A, Buza N, Margeta M, Rabban JT. Ovarian Teratomas in Women With Anti-N-methyl-D-Aspartate Receptor Encephalitis: Topography and Composition of Immune Cell and Neuroglial Populations Is Compatible With an Autoimmune Mechanism of Disease. The American Journal Of Surgical Pathology 2019, 43: 949-964. PMID: 31021857, DOI: 10.1097/PAS.0000000000001249.
- Buza N, McGregor SM, Barroilhet L, Zheng X, Hui P. Paternal uniparental isodisomy of tyrosine hydroxylase locus at chromosome 11p15.4: spectrum of phenotypical presentations simulating hydatidiform moles. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2019, 32: 1180-1188. PMID: 30952972, DOI: 10.1038/s41379-019-0266-0.
- Wu X, Snir O, Rottmann D, Wong S, Buza N, Hui P. Minimal microsatellite shift in microsatellite instability high endometrial cancer: a significant pitfall in diagnostic interpretation. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2019, 32: 650-658. PMID: 30443012, DOI: 10.1038/s41379-018-0179-3.
- Buza N. Frozen Section Diagnosis of Ovarian Epithelial Tumors: Diagnostic Pearls and Pitfalls. Archives Of Pathology & Laboratory Medicine 2019, 143: 47-64. PMID: 30785337, DOI: 10.5858/arpa.2018-0289-RA.
- Wong S, Ratner E, Buza N. Intra-operative evaluation of prophylactic hysterectomy and salpingo-oophorectomy specimens in hereditary gynaecological cancer syndromes. Histopathology 2018, 73: 109-123. PMID: 29484698, DOI: 10.1111/his.13503.
- Wong S, Hong W, Hui P, Buza N. Comprehensive Analysis of PAX8 Expression in Epithelial Malignancies of the Uterine Cervix. International Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists 2017, 36: 101-106. PMID: 27362905, DOI: 10.1097/PGP.0000000000000309.
- Buza N, Ziai J, Hui P. Mismatch repair deficiency testing in clinical practice. Expert Review Of Molecular Diagnostics 2016, 16: 591-604. PMID: 26895074, DOI: 10.1586/14737159.2016.1156533.
- Hong W, Abi-Raad R, Alomari AK, Hui P, Buza N. Diagnostic application of KRAS mutation testing in uterine microglandular proliferations. Human Pathology 2015, 46: 1000-5. PMID: 25997988, DOI: 10.1016/j.humpath.2015.03.010.
- Carr RJ, Hui P, Buza N. Intravenous leiomyomatosis revisited: an experience of 14 cases at a single medical center. International Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists 2015, 34: 169-76. PMID: 25675187, DOI: 10.1097/PGP.0000000000000127.
- Buza N, Xu F, Wu W, Carr RJ, Li P, Hui P. Recurrent chromosomal aberrations in intravenous leiomyomatosis of the uterus: high-resolution array comparative genomic hybridization study. Human Pathology 2014, 45: 1885-92. PMID: 25033729, DOI: 10.1016/j.humpath.2014.05.010.
- Abi-Raad R, Alomari A, Hui P, Buza N. Mitotically active microglandular hyperplasia of the cervix: a case series with implications for the differential diagnosis. International Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists 2014, 33: 524-30. PMID: 25083971, DOI: 10.1097/PGP.0000000000000086.
- Buza N, Roque DM, Santin AD. HER2/neu in Endometrial Cancer: A Promising Therapeutic Target With Diagnostic Challenges. Archives Of Pathology & Laboratory Medicine 2014, 138: 343-50. PMID: 24576030, DOI: 10.5858/arpa.2012-0416-RA.
- Buza N, Rutherford T, Hui P. Genotyping diagnosis of nongestational choriocarcinoma involving fallopian tube and broad ligament: a case study. International Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists 2014, 33: 58-63. PMID: 24300537, DOI: 10.1097/PGP.0b013e31827cd386.
- Yale PathologyYale New Haven Hospital20 York Street, Wing East Pavilion Fl 2ndNew Haven, CT 06510
- Yale PathologyYale New Haven Hospital20 York Street, Wing East Pavilion Fl 2ndNew Haven, CT 06510