Nuclear Medicine
Yale New Haven Hospital
20 York Street, Ste 2nd Floor
New Haven, CT 06510
- Nuclear MedicineYale New Haven Hospital20 York Street, Ste 2nd FloorNew Haven, CT 06510
Ming-Kai Chen, MD, PhD
Medical Oncology, Nuclear Medicine, Neuroradiology, Radiology & Biomedical Imaging
Patient type treated
Child, Adult
Accepting new patients
Yes
Referral required
From patients or physicians
Board Certified in
Nuclear Medicine
Biography
Ming-Kai Chen, MD, PhD, is a radiologist in the Department of Radiology & Biomedical Imaging and co-medical director of PET Center. He has special expertise in nuclear medicine—a type of imaging that uses radioactive materials to detect and treat disease—as well as oncologic molecular imaging, which is used to take detailed imagines of the body at a cellular level to detect and monitor cancer.
“With the advance of nuclear medicine and molecular imaging,” Dr. Chen says, “we often can detect the disease at an early stage (and detect more metastatic disease) compared to convention diagnostic imaging.”
Dr. Chen, an associate professor of radiology and biomedical imaging at Yale School of Medicine, is conducting research and a clinical trial about the use of PET imaging for synaptic density in the Alzheimer’s disease.
“We hope this new PET imaging could provide early diagnosis of Alzheimer’s disease and serve as a reliable biomarker for the evaluation of treatment response,” he says.
Titles
- Associate Professor of Radiology and Biomedical Imaging
- Co-Medical Director, Yale University PET Center
Education & Training
- ResidencyYale New Haven Hospital (2010)
- PhDJohns Hopkins University (2007)
- InternshipGreater Baltimore Medical Center (2006)
- Research FellowshipJohns Hopkins Hospital (2001)
- MDNational Taiwan University School of Medicine (1996)
Languages Spoken
- 官話 / 官话 (Chinese-Mandarin)
- English
Additional Information
Board Certifications
- AB of Nuclear Medicine, Nuclear Medicine (2010)
Publications
- Young J, O’Dell R, Naganawa M, Toyonaga T, Chen M, Nabulsi N, Huang Y, Cooper E, Miller A, Lam J, Bates K, Ruan A, Nelsen K, Salardini E, Carson R, van Dyck C, Mecca A. Validation of a Simplified Tissue-to-Reference Ratio Measurement Using SUVR to Assess Synaptic Density Alterations in Alzheimer Disease with [11C]UCB-J PET. Journal Of Nuclear Medicine 2024, 65: jnumed.124.267419. PMID: 39299782, PMCID: PMC11533916, DOI: 10.2967/jnumed.124.267419.
- Liu Q, Tsai Y, Gallezot J, Guo X, Chen M, Pucar D, Young C, Panin V, Casey M, Miao T, Xie H, Chen X, Zhou B, Carson R, Liu C. Population-based deep image prior for dynamic PET denoising: A data-driven approach to improve parametric quantification. Medical Image Analysis 2024, 95: 103180. PMID: 38657423, DOI: 10.1016/j.media.2024.103180.
- Fang X, Raval N, O’Dell R, Naganawa M, Mecca A, Chen M, van Dyck C, Carson R. Synaptic density patterns in early Alzheimer’s disease assessed by independent component analysis. Brain Communications 2024, 6: fcae107. PMID: 38601916, PMCID: PMC11004947, DOI: 10.1093/braincomms/fcae107.
- Toyonaga T, Khattar N, Wu Y, Lu Y, Naganawa M, Gallezot J, Matuskey D, Mecca A, Pittman B, Dias M, Nabulsi N, Finnema S, Chen M, Arnsten A, Radhakrishnan R, Skosnik P, D’Souza D, Esterlis I, Huang Y, van Dyck C, Carson R. The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [11C]UCB-J. European Journal Of Nuclear Medicine And Molecular Imaging 2023, 51: 1012-1022. PMID: 37955791, DOI: 10.1007/s00259-023-06487-8.
- Chen M, Matuskey D, Finnema S, Carson R. Synaptic PET Imaging in Neurodegeneration. 2023, 157-167. DOI: 10.1007/978-3-031-35098-6_10.
- Silva-Rudberg J, Salardini E, O'Dell R, Chen M, Ra J, Georgelos J, Morehouse M, Melino K, Varma P, Toyonaga T, Nabulsi N, Huang Y, Carson R, van Dyck C, Mecca A. Assessment of Gray Matter Microstructure and Synaptic Density in Alzheimer's Disease: A Multimodal Imaging Study With DTI and SV2A PET. American Journal Of Geriatric Psychiatry 2023, 32: 17-28. PMID: 37673749, PMCID: PMC10840732, DOI: 10.1016/j.jagp.2023.08.002.
- Guo X, Zhou B, Chen X, Chen M, Liu C, Dvornek N. MCP-Net: Introducing Patlak Loss Optimization to Whole-Body Dynamic PET Inter-Frame Motion Correction. IEEE Transactions On Medical Imaging 2023, 42: 3512-3523. PMID: 37368811, PMCID: PMC10751388, DOI: 10.1109/tmi.2023.3290003.
- O'Dell R, Higgins-Chen A, Gupta D, Chen M, Naganawa M, Toyonaga T, Lu Y, Ni G, Chupak A, Zhao W, Salardini E, Nabulsi N, Huang Y, Arnsten A, Carson R, van Dyck C, Mecca A. Principal component analysis of synaptic density measured with [11C]UCB-J PET in early Alzheimer’s disease. NeuroImage Clinical 2023, 39: 103457. PMID: 37422964, PMCID: PMC10338149, DOI: 10.1016/j.nicl.2023.103457.
- Miao T, Zhou B, Liu J, Guo X, Liu Q, Xie H, Chen X, Chen M, Wu J, Carson R, Liu C. Generation of Whole-Body FDG Parametric Ki Images From Static PET Images Using Deep Learning. IEEE Transactions On Radiation And Plasma Medical Sciences 2023, 7: 465-472. PMID: 37997577, PMCID: PMC10665031, DOI: 10.1109/trpms.2023.3243576.
- Guo X, Wu J, Chen M, Liu Q, Onofrey J, Pucar D, Pang Y, Pigg D, Casey M, Dvornek N, Liu C. Inter-Pass Motion Correction for Whole-Body Dynamic PET and Parametric Imaging. IEEE Transactions On Radiation And Plasma Medical Sciences 2022, 7: 344-353. PMID: 37842204, PMCID: PMC10569406, DOI: 10.1109/trpms.2022.3227576.
- Naganawa M, Gallezot J, Finnema S, Maguire R, Mercier J, Nabulsi N, Kervyn S, Henry S, Nicolas J, Huang Y, Chen M, Hannestad J, Klitgaard H, Stockis A, Carson R. Drug characteristics derived from kinetic modeling: combined 11C-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2A. EJNMMI Research 2022, 12: 71. PMID: 36346513, PMCID: PMC9643320, DOI: 10.1186/s13550-022-00944-5.
- Zakiniaeiz Y, Hoye J, Ryan Petrulli J, LeVasseur B, Stanley G, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Chen MK, Matuskey D, Barron DS, Kelmendi B, Fulbright RK, Hampson M, Cosgrove KP, Morris ED. Systemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers. Brain Behavior And Immunity 2022, 106: 262-269. PMID: 36058419, PMCID: PMC10097458, DOI: 10.1016/j.bbi.2022.08.016.
- Liu J, Ren S, Wang R, Mirian N, Tsai Y, Kulon M, Pucar D, Chen M, Liu C. Virtual high‐count PET image generation using a deep learning method. Medical Physics 2022, 49: 5830-5840. PMID: 35880541, PMCID: PMC9474624, DOI: 10.1002/mp.15867.
- Carson RE, Naganawa M, Toyonaga T, Koohsari S, Yang Y, Chen MK, Matuskey D, Finnema SJ. Imaging of Synaptic Density in Neurodegenerative Disorders. Journal Of Nuclear Medicine 2022, 63: 60s-67s. PMID: 35649655, DOI: 10.2967/jnumed.121.263201.
- Toyonaga T, Shao D, Shi L, Zhang J, Revilla EM, Menard D, Ankrah J, Hirata K, Chen MK, Onofrey JA, Lu Y. Deep learning–based attenuation correction for whole-body PET — a multi-tracer study with 18F-FDG, 68 Ga-DOTATATE, and 18F-Fluciclovine. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 49: 3086-3097. PMID: 35277742, PMCID: PMC10725742, DOI: 10.1007/s00259-022-05748-2.
- Mecca AP, O'Dell RS, Sharp ES, Banks ER, Bartlett HH, Zhao W, Lipior S, Diepenbrock NG, Chen M, Naganawa M, Toyonaga T, Nabulsi NB, Vander Wyk B, Arnsten AFT, Huang Y, Carson RE, van Dyck C. Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [11C]UCB‐J. Alzheimer's & Dementia 2022, 18: 2527-2536. PMID: 35174954, PMCID: PMC9381645, DOI: 10.1002/alz.12582.
- Zakiniaeiz Y, Liu H, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Matuskey D, Chen MK, Cosgrove KP, Morris ED. Nicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment Response. Nicotine & Tobacco Research 2022, 24: 1597-1606. PMID: 35100429, PMCID: PMC9575980, DOI: 10.1093/ntr/ntac026.
- Liu H, Yousefi H, Mirian N, Lin M, Menard D, Gregory M, Aboian M, Boustani A, Chen M, Saperstein L, Pucar D, Kulon M, Liu C. PET Image Denoising Using a Deep-Learning Method for Extremely Obese Patients. IEEE Transactions On Radiation And Plasma Medical Sciences 2021, 6: 766-770. PMID: 37284026, PMCID: PMC10241407, DOI: 10.1109/trpms.2021.3131999.
- Mecca AP, Chen MK, O'Dell RS, Naganawa M, Toyonaga T, Godek TA, Harris JE, Bartlett HH, Zhao W, Banks ER, Ni GS, Rogers K, Gallezot JD, Ropchan J, Emery PR, Nabulsi NB, Vander Wyk BC, Arnsten AFT, Huang Y, Carson RE, van Dyck CH. Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's disease. Neurobiology Of Aging 2021, 111: 44-53. PMID: 34963063, PMCID: PMC8761170, DOI: 10.1016/j.neurobiolaging.2021.11.004.
- Cheng D, Ghita M, Menard D, Chen MK. Determining the Minimal Required Ultra-Low-Dose CT Dose Level for Reliable Attenuation Correction of 18F-FDG PET/CT: A Phantom Study. Journal Of Nuclear Medicine Technology 2021, 50: 126-131. PMID: 34750234, DOI: 10.2967/jnmt.121.262943.
- Ren S, Liu J, Xie H, Toyonaga T, Mirian N, Chen M, Aboian M, Carson R, Liu C. Super-resolution PET Brain Imaging using Deep Learning. 2021, 00: 1-6. DOI: 10.1109/nss/mic44867.2021.9875548.
- Zhou B, Wang R, Chen M, Mecca A, O’Dell R, Van Dyck C, Carson R, Duncan J, Liu C. Synthesizing Multi-tracer PET Images for Alzheimer’s Disease Patients Using a 3D Unified Anatomy-Aware Cyclic Adversarial Network. Lecture Notes In Computer Science 2021, 12906: 34-43. DOI: 10.1007/978-3-030-87231-1_4.
- Wu J, Liu H, Ye Q, Gallezot J, Naganawa M, Miao T, Lu Y, Chen M, Esserman DA, Kyriakides TC, Carson RE, Liu C. Generation of parametric Ki images for FDG PET using two 5‐min scans. Medical Physics 2021, 48: 5219-5231. PMID: 34287939, DOI: 10.1002/mp.15113.
- Wang R, Liu H, Toyonaga T, Shi L, Wu J, Onofrey JA, Tsai Y, Naganawa M, Ma T, Liu Y, Chen M, Mecca AP, O’Dell R, van Dyck C, Carson RE, Liu C. Generation of synthetic PET images of synaptic density and amyloid from 18F‐FDG images using deep learning. Medical Physics 2021, 48: 5115-5129. PMID: 34224153, PMCID: PMC8455448, DOI: 10.1002/mp.15073.
- Lu Y, Toyonaga T, Naganawa M, Gallezot JD, Chen MK, Mecca AP, van Dyck CH, Carson RE. Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease. NeuroImage 2021, 238: 118248. PMID: 34119639, PMCID: PMC8454285, DOI: 10.1016/j.neuroimage.2021.118248.
- Chen MK, Mecca AP, Naganawa M, Gallezot JD, Toyonaga T, Mondal J, Finnema SJ, Lin SF, O’Dell R, McDonald JW, Michalak HR, Vander Wyk B, Nabulsi NB, Huang Y, Arnsten AF, van Dyck CH, Carson RE. Comparison of [11C]UCB-J and [18F]FDG PET in Alzheimer’s disease: A tracer kinetic modeling study. Cerebrovascular And Brain Metabolism Reviews 2021, 41: 2395-2409. PMID: 33757318, PMCID: PMC8393289, DOI: 10.1177/0271678x211004312.
- O’Dell R, Mecca AP, Chen MK, Naganawa M, Toyonaga T, Lu Y, Godek TA, Harris JE, Bartlett HH, Banks ER, Kominek VL, Zhao W, Nabulsi NB, Ropchan J, Ye Y, Vander Wyk BC, Huang Y, Arnsten AFT, Carson RE, van Dyck CH. Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-J. Alzheimer's Research & Therapy 2021, 13: 11. PMID: 33402201, PMCID: PMC7786921, DOI: 10.1186/s13195-020-00742-y.
- Naganawa M, Gallezot JD, Shah V, Mulnix T, Young C, Dias M, Chen MK, Smith AM, Carson RE. Assessment of population-based input functions for Patlak imaging of whole body dynamic 18F-FDG PET. EJNMMI Physics 2020, 7: 67. PMID: 33226522, PMCID: PMC7683759, DOI: 10.1186/s40658-020-00330-x.
- Finnema S, Li S, Cai Z, Naganawa M, Chen M, Matuskey D, Nabulsi N, Esterlis I, Holmes S, Radhakrishnan R, Toyonaga T, Huang Y, Carson R. PET Imaging of Synaptic Vesicle Protein 2A. 2020, 993-1019. DOI: 10.1007/978-3-030-53176-8_29.
- Finnema SJ, Toyonaga T, Detyniecki K, Chen M, Dias M, Wang Q, Lin S, Naganawa M, Gallezot J, Lu Y, Nabulsi NB, Huang Y, Spencer DD, Carson RE. Reduced synaptic vesicle protein 2A binding in temporal lobe epilepsy: A [11C]UCB‐J positron emission tomography study. Epilepsia 2020, 61: 2183-2193. PMID: 32944949, DOI: 10.1111/epi.16653.
- Smart K, Liu H, Matuskey D, Chen MK, Torres K, Nabulsi N, Labaree D, Ropchan J, Hillmer AT, Huang Y, Carson RE. Binding of the synaptic vesicle radiotracer [11C]UCB-J is unchanged during functional brain activation using a visual stimulation task. Cerebrovascular And Brain Metabolism Reviews 2020, 41: 1067-1079. PMID: 32757741, PMCID: PMC8054713, DOI: 10.1177/0271678x20946198.
- Mecca AP, Chen M, O'Dell RS, Naganawa M, Toyonaga T, Godek TA, Harris JE, Bartlett HH, Zhao W, Nabulsi NB, Vander Wyk B, Varma P, Arnsten AFT, Huang Y, Carson RE, van Dyck C. In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET. Alzheimer's & Dementia 2020, 16: 974-982. PMID: 32400950, PMCID: PMC7383876, DOI: 10.1002/alz.12097.
- Mecca AP, McDonald JW, Michalak HR, Godek TA, Harris JE, Pugh EA, Kemp EC, Chen MK, Salardini A, Nabulsi NB, Lim K, Huang Y, Carson RE, Strittmatter SM, van Dyck CH. PET imaging of mGluR5 in Alzheimer’s disease. Alzheimer's Research & Therapy 2020, 12: 15. PMID: 31954399, PMCID: PMC6969979, DOI: 10.1186/s13195-020-0582-0.
- Sanchez-Rangel E, Gallezot JD, Yeckel CW, Lam W, Belfort-DeAguiar R, Chen MK, Carson RE, Sherwin R, Hwang JJ. Norepinephrine transporter availability in brown fat is reduced in obesity: a human PET study with [11C] MRB. International Journal Of Obesity 2019, 44: 964-967. PMID: 31636373, PMCID: PMC7259982, DOI: 10.1038/s41366-019-0471-4.
- Tuisku J, Plavén-Sigray P, Gaiser EC, Airas L, Al-Abdulrasul H, Brück A, Carson RE, Chen MK, Cosgrove KP, Ekblad L, Esterlis I, Farde L, Forsberg A, Halldin C, Helin S, Kosek E, Lekander M, Lindgren N, Marjamäki P, Rissanen E, Sucksdorff M, Varrone A, Collste K, Gallezot J, Hillmer A, Huang Y, Höglund C, Johansson J, Jucaite A, Lampa J, Nabulsi N, Pittman B, Sandiego C, Stenkrona P, Rinne J, Matuskey D, Cervenka S. Effects of age, BMI and sex on the glial cell marker TSPO — a multicentre [11C]PBR28 HRRT PET study. European Journal Of Nuclear Medicine And Molecular Imaging 2019, 46: 2329-2338. PMID: 31363804, PMCID: PMC6717599, DOI: 10.1007/s00259-019-04403-7.
- Mahalingam S, Chen MK. Neuroimaging in Dementias. Seminars In Neurology 2019, 39: 188-199. PMID: 30925612, DOI: 10.1055/s-0039-1678580.
- Chen MK, Mecca AP, Naganawa M, Finnema SJ, Toyonaga T, Lin SF, Najafzadeh S, Ropchan J, Lu Y, McDonald JW, Michalak HR, Nabulsi NB, Arnsten AFT, Huang Y, Carson RE, van Dyck CH. Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging. JAMA Neurology 2018, 75: 1215-1224. PMID: 30014145, PMCID: PMC6233853, DOI: 10.1001/jamaneurol.2018.1836.
- Ye Q, Wu J, Lu Y, Naganawa M, Gallezot JD, Ma T, Liu Y, Tanoue L, Detterbeck F, Blasberg J, Chen MK, Casey M, Carson RE, Liu C. Improved discrimination between benign and malignant LDCT screening-detected lung nodules with dynamic over static 18F-FDG PET as a function of injected dose. Physics In Medicine And Biology 2018, 63: 175015. PMID: 30095083, PMCID: PMC6158045, DOI: 10.1088/1361-6560/aad97f.
- Finnema SJ, Nabulsi NB, Mercier J, Lin SF, Chen MK, Matuskey D, Gallezot JD, Henry S, Hannestad J, Huang Y, Carson RE. Kinetic evaluation and test–retest reproducibility of [11C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans. Cerebrovascular And Brain Metabolism Reviews 2017, 38: 2041-2052. PMID: 28792356, PMCID: PMC6259313, DOI: 10.1177/0271678x17724947.
- Finnema S, Mercier J, Naganawa M, Nabulsi N, Kervyn S, Henry S, Nicolas J, Huang Y, Chen M, Hannestad J, Klitgaard H, Stockis A, Carson R. Brivaracetam enters the brain faster than levetiracetam: a PET study in healthy volunteers (P6.233). Neurology 2017, 88 DOI: 10.1212/wnl.88.16_supplement.p6.233.
- Morbelli S, Arbizu J, Booij J, Chen MK, Chetelat G, Cross DJ, Djekidel M, Drzezga A, Ekmekcioglu O, Garibotto V, Hesse S, Ishii K, Saraf LJ, Lammertsma AA, Law I, Mathews D, Minoshima S, Mosci K, Pagani M, Pappata S, Silverman DH, Signore A, Van De Giessen E, Villemagne V, Barthel H, on behalf of the European Association of Nuclear Medicine (EANM) and of the Society of Nuclear Medicine and Molecular Imaging (SNMMI). The need of standardization and of large clinical studies in an emerging indication of [18F]FDG PET: the autoimmune encephalitis. European Journal Of Nuclear Medicine And Molecular Imaging 2016, 44: 353-357. PMID: 27924371, DOI: 10.1007/s00259-016-3589-9.
- Finnema SJ, Nabulsi NB, Eid T, Detyniecki K, Lin SF, Chen MK, Dhaher R, Matuskey D, Baum E, Holden D, Spencer DD, Mercier J, Hannestad J, Huang Y, Carson RE. Imaging synaptic density in the living human brain. Science Translational Medicine 2016, 8: 348ra96. PMID: 27440727, DOI: 10.1126/scitranslmed.aaf6667.
- Chen MK, Menard DH, Cheng DW. Determining the Minimal Required Radioactivity of 18F-FDG for Reliable Semiquantification in PET/CT Imaging: A Phantom Study. Journal Of Nuclear Medicine Technology 2016, 44: 26-30. PMID: 26769598, DOI: 10.2967/jnmt.115.165258.
- Park E, Gallezot JD, Delgadillo A, Liu S, Planeta B, Lin SF, O’Connor K, Lim K, Lee JY, Chastre A, Chen MK, Seneca N, Leppert D, Huang Y, Carson RE, Pelletier D. 11C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areas. European Journal Of Nuclear Medicine And Molecular Imaging 2015, 42: 1081-1092. PMID: 25833352, DOI: 10.1007/s00259-015-3043-4.
- Chen MK, Cheng DW. What is the role of dosimetry in patients with advanced thyroid cancer? Current Opinion In Oncology 2015, 27: 33-37. PMID: 25319079, DOI: 10.1097/cco.0000000000000145.
- Lin S, Labaree D, Chen M, Holden D, Gallezot J, Kapinos M, Teng J, Najafzadeh S, Plisson C, Rabiner EA, Gunn RN, Carson RE, Huang Y. Further evaluation of [11C]MP‐10 as a radiotracer for phosphodiesterase 10A: PET imaging study in rhesus monkeys and brain tissue metabolite analysis. Synapse 2014, 69: 86-95. PMID: 25450608, PMCID: PMC4275380, DOI: 10.1002/syn.21792.
- Caporizzo DJ, Kwiatkowski AE, Chen MK, Beck AP, Booth CJ, Zeiss C, Smith PC, Carlson Scholz JA, Wilson SR. Use of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography to aid in diagnosing intestinal adenocarcinoma in 2 rhesus macaques (Macaca mulatta). Comparative Medicine 2014, 64: 211-20. PMID: 24956213, PMCID: PMC4067585.
- Chen MK, Yasrebi M, Samii J, Staib LH, Doddamane I, Cheng DW. The Utility of I-123 Pretherapy Scan in I-131 Radioiodine Therapy for Thyroid Cancer. Thyroid 2012, 22: 304-309. PMID: 22300251, DOI: 10.1089/thy.2011.0203.
- Chen MK, Doddamane I, Cheng DW. Recombinant human thyroid-stimulating hormone as an alternative for thyroid hormone withdrawal in thyroid cancer management. Current Opinion In Oncology 2010, 22: 6-10. PMID: 19844179, DOI: 10.1097/cco.0b013e3283339d5d.
- Chen MK, Guilarte TR. Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair. Pharmacology & Therapeutics 2008, 118: 1-17. PMID: 18374421, PMCID: PMC2453598, DOI: 10.1016/j.pharmthera.2007.12.004.
- Chen MK, Kuwabara H, Zhou Y, Adams RJ, Brasić JR, McGlothan JL, Verina T, Burton NC, Alexander M, Kumar A, Wong DF, Guilarte TR. VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease. Journal Of Neurochemistry 2008, 105: 78-90. PMID: 17988241, PMCID: PMC4137401, DOI: 10.1111/j.1471-4159.2007.05108.x.
- Guilarte TR, Chen MK. Manganese inhibits NMDA receptor channel function: implications to psychiatric and cognitive effects. Neurotoxicology 2007, 28: 1147-52. PMID: 17662456, PMCID: PMC2100416, DOI: 10.1016/j.neuro.2007.06.005.
- Guilarte TR, Chen MK, McGlothan JL, Verina T, Wong DF, Zhou Y, Alexander M, Rohde CA, Syversen T, Decamp E, Koser AJ, Fritz S, Gonczi H, Anderson DW, Schneider JS. Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates. Experimental Neurology 2006, 202: 381-90. PMID: 16925997, DOI: 10.1016/j.expneurol.2006.06.015.
- Guilarte TR, McGlothan JL, Degaonkar M, Chen MK, Barker PB, Syversen T, Schneider JS. Evidence for cortical dysfunction and widespread manganese accumulation in the nonhuman primate brain following chronic manganese exposure: a 1H-MRS and MRI study. Toxicological Sciences : An Official Journal Of The Society Of Toxicology 2006, 94: 351-8. PMID: 16968886, DOI: 10.1093/toxsci/kfl106.
- Zhou Y, Chen MK, Endres CJ, Ye W, Brasic JR, Alexander M, Crabb AH, Guilarte TR, Wong DF. An extended simplified reference tissue model for the quantification of dynamic PET with amphetamine challenge. NeuroImage 2006, 33: 550-63. PMID: 16920365, DOI: 10.1016/j.neuroimage.2006.06.038.
- Chen MK, Guilarte TR. Imaging the peripheral benzodiazepine receptor response in central nervous system demyelination and remyelination. Toxicological Sciences : An Official Journal Of The Society Of Toxicology 2006, 91: 532-9. PMID: 16554315, DOI: 10.1093/toxsci/kfj172.
- Acute manganese administration alters dopamine transporter levels in the non-human primate striatum.Chen MK, Lee JS, McGlothan JL, Furukawa E, Adams RJ, Alexander M, Wong DF, Guilarte TR. Acute manganese administration alters dopamine transporter levels in the non-human primate striatum. Neurotoxicology 2006, 27: 229-36. PMID: 16325911, DOI: 10.1016/j.neuro.2005.10.008.
- Hardwick MJ, Chen MK, Baidoo K, Pomper MG, Guilarte TR. In vivo imaging of peripheral benzodiazepine receptors in mouse lungs: a biomarker of inflammation. Molecular Imaging 2005, 4: 432-8. PMID: 16285905.
- Lin KS, Luu A, Baidoo KE, Hashemzadeh-Gargari H, Chen MK, Brenneman K, Pili R, Pomper M, Carducci MA, Wagner HN. A new high affinity technetium-99m-bombesin analogue with low abdominal accumulation. Bioconjugate Chemistry 2005, 16: 43-50. PMID: 15656574, DOI: 10.1021/bc049820h.
- Lin KS, Luu A, Baidoo KE, Hashemzadeh-Gargari H, Chen MK, Pili R, Pomper M, Carducci M, Wagner HN. A new high affinity technetium analogue of bombesin containing DTPA as a pharmacokinetic modifier. Bioconjugate Chemistry 2004, 15: 1416-23. PMID: 15546210, DOI: 10.1021/bc0498267.
- Chen MK, Baidoo K, Verina T, Guilarte TR. Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization. Brain : A Journal Of Neurology 2004, 127: 1379-92. PMID: 15069023, DOI: 10.1093/brain/awh161.
Departments and Programs
Locations
Nuclear Medicine
Yale New Haven Hospital
20 York Street, Ste 2nd Floor
New Haven, CT 06510
- Nuclear MedicineYale New Haven Hospital20 York Street, Ste 2nd FloorNew Haven, CT 06510
Biography
Ming-Kai Chen, MD, PhD, is a radiologist in the Department of Radiology & Biomedical Imaging and co-medical director of PET Center. He has special expertise in nuclear medicine—a type of imaging that uses radioactive materials to detect and treat disease—as well as oncologic molecular imaging, which is used to take detailed imagines of the body at a cellular level to detect and monitor cancer.
“With the advance of nuclear medicine and molecular imaging,” Dr. Chen says, “we often can detect the disease at an early stage (and detect more metastatic disease) compared to convention diagnostic imaging.”
Dr. Chen, an associate professor of radiology and biomedical imaging at Yale School of Medicine, is conducting research and a clinical trial about the use of PET imaging for synaptic density in the Alzheimer’s disease.
“We hope this new PET imaging could provide early diagnosis of Alzheimer’s disease and serve as a reliable biomarker for the evaluation of treatment response,” he says.
Titles
- Associate Professor of Radiology and Biomedical Imaging
- Co-Medical Director, Yale University PET Center
Education & Training
- ResidencyYale New Haven Hospital (2010)
- PhDJohns Hopkins University (2007)
- InternshipGreater Baltimore Medical Center (2006)
- Research FellowshipJohns Hopkins Hospital (2001)
- MDNational Taiwan University School of Medicine (1996)
Languages Spoken
- 官話 / 官话 (Chinese-Mandarin)
- English
Additional Information
Board Certifications
- AB of Nuclear Medicine, Nuclear Medicine (2010)
Publications
- Young J, O’Dell R, Naganawa M, Toyonaga T, Chen M, Nabulsi N, Huang Y, Cooper E, Miller A, Lam J, Bates K, Ruan A, Nelsen K, Salardini E, Carson R, van Dyck C, Mecca A. Validation of a Simplified Tissue-to-Reference Ratio Measurement Using SUVR to Assess Synaptic Density Alterations in Alzheimer Disease with [11C]UCB-J PET. Journal Of Nuclear Medicine 2024, 65: jnumed.124.267419. PMID: 39299782, PMCID: PMC11533916, DOI: 10.2967/jnumed.124.267419.
- Liu Q, Tsai Y, Gallezot J, Guo X, Chen M, Pucar D, Young C, Panin V, Casey M, Miao T, Xie H, Chen X, Zhou B, Carson R, Liu C. Population-based deep image prior for dynamic PET denoising: A data-driven approach to improve parametric quantification. Medical Image Analysis 2024, 95: 103180. PMID: 38657423, DOI: 10.1016/j.media.2024.103180.
- Fang X, Raval N, O’Dell R, Naganawa M, Mecca A, Chen M, van Dyck C, Carson R. Synaptic density patterns in early Alzheimer’s disease assessed by independent component analysis. Brain Communications 2024, 6: fcae107. PMID: 38601916, PMCID: PMC11004947, DOI: 10.1093/braincomms/fcae107.
- Toyonaga T, Khattar N, Wu Y, Lu Y, Naganawa M, Gallezot J, Matuskey D, Mecca A, Pittman B, Dias M, Nabulsi N, Finnema S, Chen M, Arnsten A, Radhakrishnan R, Skosnik P, D’Souza D, Esterlis I, Huang Y, van Dyck C, Carson R. The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [11C]UCB-J. European Journal Of Nuclear Medicine And Molecular Imaging 2023, 51: 1012-1022. PMID: 37955791, DOI: 10.1007/s00259-023-06487-8.
- Chen M, Matuskey D, Finnema S, Carson R. Synaptic PET Imaging in Neurodegeneration. 2023, 157-167. DOI: 10.1007/978-3-031-35098-6_10.
- Silva-Rudberg J, Salardini E, O'Dell R, Chen M, Ra J, Georgelos J, Morehouse M, Melino K, Varma P, Toyonaga T, Nabulsi N, Huang Y, Carson R, van Dyck C, Mecca A. Assessment of Gray Matter Microstructure and Synaptic Density in Alzheimer's Disease: A Multimodal Imaging Study With DTI and SV2A PET. American Journal Of Geriatric Psychiatry 2023, 32: 17-28. PMID: 37673749, PMCID: PMC10840732, DOI: 10.1016/j.jagp.2023.08.002.
- Guo X, Zhou B, Chen X, Chen M, Liu C, Dvornek N. MCP-Net: Introducing Patlak Loss Optimization to Whole-Body Dynamic PET Inter-Frame Motion Correction. IEEE Transactions On Medical Imaging 2023, 42: 3512-3523. PMID: 37368811, PMCID: PMC10751388, DOI: 10.1109/tmi.2023.3290003.
- O'Dell R, Higgins-Chen A, Gupta D, Chen M, Naganawa M, Toyonaga T, Lu Y, Ni G, Chupak A, Zhao W, Salardini E, Nabulsi N, Huang Y, Arnsten A, Carson R, van Dyck C, Mecca A. Principal component analysis of synaptic density measured with [11C]UCB-J PET in early Alzheimer’s disease. NeuroImage Clinical 2023, 39: 103457. PMID: 37422964, PMCID: PMC10338149, DOI: 10.1016/j.nicl.2023.103457.
- Miao T, Zhou B, Liu J, Guo X, Liu Q, Xie H, Chen X, Chen M, Wu J, Carson R, Liu C. Generation of Whole-Body FDG Parametric Ki Images From Static PET Images Using Deep Learning. IEEE Transactions On Radiation And Plasma Medical Sciences 2023, 7: 465-472. PMID: 37997577, PMCID: PMC10665031, DOI: 10.1109/trpms.2023.3243576.
- Guo X, Wu J, Chen M, Liu Q, Onofrey J, Pucar D, Pang Y, Pigg D, Casey M, Dvornek N, Liu C. Inter-Pass Motion Correction for Whole-Body Dynamic PET and Parametric Imaging. IEEE Transactions On Radiation And Plasma Medical Sciences 2022, 7: 344-353. PMID: 37842204, PMCID: PMC10569406, DOI: 10.1109/trpms.2022.3227576.
- Naganawa M, Gallezot J, Finnema S, Maguire R, Mercier J, Nabulsi N, Kervyn S, Henry S, Nicolas J, Huang Y, Chen M, Hannestad J, Klitgaard H, Stockis A, Carson R. Drug characteristics derived from kinetic modeling: combined 11C-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2A. EJNMMI Research 2022, 12: 71. PMID: 36346513, PMCID: PMC9643320, DOI: 10.1186/s13550-022-00944-5.
- Zakiniaeiz Y, Hoye J, Ryan Petrulli J, LeVasseur B, Stanley G, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Chen MK, Matuskey D, Barron DS, Kelmendi B, Fulbright RK, Hampson M, Cosgrove KP, Morris ED. Systemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers. Brain Behavior And Immunity 2022, 106: 262-269. PMID: 36058419, PMCID: PMC10097458, DOI: 10.1016/j.bbi.2022.08.016.
- Liu J, Ren S, Wang R, Mirian N, Tsai Y, Kulon M, Pucar D, Chen M, Liu C. Virtual high‐count PET image generation using a deep learning method. Medical Physics 2022, 49: 5830-5840. PMID: 35880541, PMCID: PMC9474624, DOI: 10.1002/mp.15867.
- Carson RE, Naganawa M, Toyonaga T, Koohsari S, Yang Y, Chen MK, Matuskey D, Finnema SJ. Imaging of Synaptic Density in Neurodegenerative Disorders. Journal Of Nuclear Medicine 2022, 63: 60s-67s. PMID: 35649655, DOI: 10.2967/jnumed.121.263201.
- Toyonaga T, Shao D, Shi L, Zhang J, Revilla EM, Menard D, Ankrah J, Hirata K, Chen MK, Onofrey JA, Lu Y. Deep learning–based attenuation correction for whole-body PET — a multi-tracer study with 18F-FDG, 68 Ga-DOTATATE, and 18F-Fluciclovine. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 49: 3086-3097. PMID: 35277742, PMCID: PMC10725742, DOI: 10.1007/s00259-022-05748-2.
- Mecca AP, O'Dell RS, Sharp ES, Banks ER, Bartlett HH, Zhao W, Lipior S, Diepenbrock NG, Chen M, Naganawa M, Toyonaga T, Nabulsi NB, Vander Wyk B, Arnsten AFT, Huang Y, Carson RE, van Dyck C. Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [11C]UCB‐J. Alzheimer's & Dementia 2022, 18: 2527-2536. PMID: 35174954, PMCID: PMC9381645, DOI: 10.1002/alz.12582.
- Zakiniaeiz Y, Liu H, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Matuskey D, Chen MK, Cosgrove KP, Morris ED. Nicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment Response. Nicotine & Tobacco Research 2022, 24: 1597-1606. PMID: 35100429, PMCID: PMC9575980, DOI: 10.1093/ntr/ntac026.
- Liu H, Yousefi H, Mirian N, Lin M, Menard D, Gregory M, Aboian M, Boustani A, Chen M, Saperstein L, Pucar D, Kulon M, Liu C. PET Image Denoising Using a Deep-Learning Method for Extremely Obese Patients. IEEE Transactions On Radiation And Plasma Medical Sciences 2021, 6: 766-770. PMID: 37284026, PMCID: PMC10241407, DOI: 10.1109/trpms.2021.3131999.
- Mecca AP, Chen MK, O'Dell RS, Naganawa M, Toyonaga T, Godek TA, Harris JE, Bartlett HH, Zhao W, Banks ER, Ni GS, Rogers K, Gallezot JD, Ropchan J, Emery PR, Nabulsi NB, Vander Wyk BC, Arnsten AFT, Huang Y, Carson RE, van Dyck CH. Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's disease. Neurobiology Of Aging 2021, 111: 44-53. PMID: 34963063, PMCID: PMC8761170, DOI: 10.1016/j.neurobiolaging.2021.11.004.
- Cheng D, Ghita M, Menard D, Chen MK. Determining the Minimal Required Ultra-Low-Dose CT Dose Level for Reliable Attenuation Correction of 18F-FDG PET/CT: A Phantom Study. Journal Of Nuclear Medicine Technology 2021, 50: 126-131. PMID: 34750234, DOI: 10.2967/jnmt.121.262943.
- Ren S, Liu J, Xie H, Toyonaga T, Mirian N, Chen M, Aboian M, Carson R, Liu C. Super-resolution PET Brain Imaging using Deep Learning. 2021, 00: 1-6. DOI: 10.1109/nss/mic44867.2021.9875548.
- Zhou B, Wang R, Chen M, Mecca A, O’Dell R, Van Dyck C, Carson R, Duncan J, Liu C. Synthesizing Multi-tracer PET Images for Alzheimer’s Disease Patients Using a 3D Unified Anatomy-Aware Cyclic Adversarial Network. Lecture Notes In Computer Science 2021, 12906: 34-43. DOI: 10.1007/978-3-030-87231-1_4.
- Wu J, Liu H, Ye Q, Gallezot J, Naganawa M, Miao T, Lu Y, Chen M, Esserman DA, Kyriakides TC, Carson RE, Liu C. Generation of parametric Ki images for FDG PET using two 5‐min scans. Medical Physics 2021, 48: 5219-5231. PMID: 34287939, DOI: 10.1002/mp.15113.
- Wang R, Liu H, Toyonaga T, Shi L, Wu J, Onofrey JA, Tsai Y, Naganawa M, Ma T, Liu Y, Chen M, Mecca AP, O’Dell R, van Dyck C, Carson RE, Liu C. Generation of synthetic PET images of synaptic density and amyloid from 18F‐FDG images using deep learning. Medical Physics 2021, 48: 5115-5129. PMID: 34224153, PMCID: PMC8455448, DOI: 10.1002/mp.15073.
- Lu Y, Toyonaga T, Naganawa M, Gallezot JD, Chen MK, Mecca AP, van Dyck CH, Carson RE. Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease. NeuroImage 2021, 238: 118248. PMID: 34119639, PMCID: PMC8454285, DOI: 10.1016/j.neuroimage.2021.118248.
- Chen MK, Mecca AP, Naganawa M, Gallezot JD, Toyonaga T, Mondal J, Finnema SJ, Lin SF, O’Dell R, McDonald JW, Michalak HR, Vander Wyk B, Nabulsi NB, Huang Y, Arnsten AF, van Dyck CH, Carson RE. Comparison of [11C]UCB-J and [18F]FDG PET in Alzheimer’s disease: A tracer kinetic modeling study. Cerebrovascular And Brain Metabolism Reviews 2021, 41: 2395-2409. PMID: 33757318, PMCID: PMC8393289, DOI: 10.1177/0271678x211004312.
- O’Dell R, Mecca AP, Chen MK, Naganawa M, Toyonaga T, Lu Y, Godek TA, Harris JE, Bartlett HH, Banks ER, Kominek VL, Zhao W, Nabulsi NB, Ropchan J, Ye Y, Vander Wyk BC, Huang Y, Arnsten AFT, Carson RE, van Dyck CH. Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-J. Alzheimer's Research & Therapy 2021, 13: 11. PMID: 33402201, PMCID: PMC7786921, DOI: 10.1186/s13195-020-00742-y.
- Naganawa M, Gallezot JD, Shah V, Mulnix T, Young C, Dias M, Chen MK, Smith AM, Carson RE. Assessment of population-based input functions for Patlak imaging of whole body dynamic 18F-FDG PET. EJNMMI Physics 2020, 7: 67. PMID: 33226522, PMCID: PMC7683759, DOI: 10.1186/s40658-020-00330-x.
- Finnema S, Li S, Cai Z, Naganawa M, Chen M, Matuskey D, Nabulsi N, Esterlis I, Holmes S, Radhakrishnan R, Toyonaga T, Huang Y, Carson R. PET Imaging of Synaptic Vesicle Protein 2A. 2020, 993-1019. DOI: 10.1007/978-3-030-53176-8_29.
- Finnema SJ, Toyonaga T, Detyniecki K, Chen M, Dias M, Wang Q, Lin S, Naganawa M, Gallezot J, Lu Y, Nabulsi NB, Huang Y, Spencer DD, Carson RE. Reduced synaptic vesicle protein 2A binding in temporal lobe epilepsy: A [11C]UCB‐J positron emission tomography study. Epilepsia 2020, 61: 2183-2193. PMID: 32944949, DOI: 10.1111/epi.16653.
- Smart K, Liu H, Matuskey D, Chen MK, Torres K, Nabulsi N, Labaree D, Ropchan J, Hillmer AT, Huang Y, Carson RE. Binding of the synaptic vesicle radiotracer [11C]UCB-J is unchanged during functional brain activation using a visual stimulation task. Cerebrovascular And Brain Metabolism Reviews 2020, 41: 1067-1079. PMID: 32757741, PMCID: PMC8054713, DOI: 10.1177/0271678x20946198.
- Mecca AP, Chen M, O'Dell RS, Naganawa M, Toyonaga T, Godek TA, Harris JE, Bartlett HH, Zhao W, Nabulsi NB, Vander Wyk B, Varma P, Arnsten AFT, Huang Y, Carson RE, van Dyck C. In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET. Alzheimer's & Dementia 2020, 16: 974-982. PMID: 32400950, PMCID: PMC7383876, DOI: 10.1002/alz.12097.
- Mecca AP, McDonald JW, Michalak HR, Godek TA, Harris JE, Pugh EA, Kemp EC, Chen MK, Salardini A, Nabulsi NB, Lim K, Huang Y, Carson RE, Strittmatter SM, van Dyck CH. PET imaging of mGluR5 in Alzheimer’s disease. Alzheimer's Research & Therapy 2020, 12: 15. PMID: 31954399, PMCID: PMC6969979, DOI: 10.1186/s13195-020-0582-0.
- Sanchez-Rangel E, Gallezot JD, Yeckel CW, Lam W, Belfort-DeAguiar R, Chen MK, Carson RE, Sherwin R, Hwang JJ. Norepinephrine transporter availability in brown fat is reduced in obesity: a human PET study with [11C] MRB. International Journal Of Obesity 2019, 44: 964-967. PMID: 31636373, PMCID: PMC7259982, DOI: 10.1038/s41366-019-0471-4.
- Tuisku J, Plavén-Sigray P, Gaiser EC, Airas L, Al-Abdulrasul H, Brück A, Carson RE, Chen MK, Cosgrove KP, Ekblad L, Esterlis I, Farde L, Forsberg A, Halldin C, Helin S, Kosek E, Lekander M, Lindgren N, Marjamäki P, Rissanen E, Sucksdorff M, Varrone A, Collste K, Gallezot J, Hillmer A, Huang Y, Höglund C, Johansson J, Jucaite A, Lampa J, Nabulsi N, Pittman B, Sandiego C, Stenkrona P, Rinne J, Matuskey D, Cervenka S. Effects of age, BMI and sex on the glial cell marker TSPO — a multicentre [11C]PBR28 HRRT PET study. European Journal Of Nuclear Medicine And Molecular Imaging 2019, 46: 2329-2338. PMID: 31363804, PMCID: PMC6717599, DOI: 10.1007/s00259-019-04403-7.
- Mahalingam S, Chen MK. Neuroimaging in Dementias. Seminars In Neurology 2019, 39: 188-199. PMID: 30925612, DOI: 10.1055/s-0039-1678580.
- Chen MK, Mecca AP, Naganawa M, Finnema SJ, Toyonaga T, Lin SF, Najafzadeh S, Ropchan J, Lu Y, McDonald JW, Michalak HR, Nabulsi NB, Arnsten AFT, Huang Y, Carson RE, van Dyck CH. Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging. JAMA Neurology 2018, 75: 1215-1224. PMID: 30014145, PMCID: PMC6233853, DOI: 10.1001/jamaneurol.2018.1836.
- Ye Q, Wu J, Lu Y, Naganawa M, Gallezot JD, Ma T, Liu Y, Tanoue L, Detterbeck F, Blasberg J, Chen MK, Casey M, Carson RE, Liu C. Improved discrimination between benign and malignant LDCT screening-detected lung nodules with dynamic over static 18F-FDG PET as a function of injected dose. Physics In Medicine And Biology 2018, 63: 175015. PMID: 30095083, PMCID: PMC6158045, DOI: 10.1088/1361-6560/aad97f.
- Finnema SJ, Nabulsi NB, Mercier J, Lin SF, Chen MK, Matuskey D, Gallezot JD, Henry S, Hannestad J, Huang Y, Carson RE. Kinetic evaluation and test–retest reproducibility of [11C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans. Cerebrovascular And Brain Metabolism Reviews 2017, 38: 2041-2052. PMID: 28792356, PMCID: PMC6259313, DOI: 10.1177/0271678x17724947.
- Finnema S, Mercier J, Naganawa M, Nabulsi N, Kervyn S, Henry S, Nicolas J, Huang Y, Chen M, Hannestad J, Klitgaard H, Stockis A, Carson R. Brivaracetam enters the brain faster than levetiracetam: a PET study in healthy volunteers (P6.233). Neurology 2017, 88 DOI: 10.1212/wnl.88.16_supplement.p6.233.
- Morbelli S, Arbizu J, Booij J, Chen MK, Chetelat G, Cross DJ, Djekidel M, Drzezga A, Ekmekcioglu O, Garibotto V, Hesse S, Ishii K, Saraf LJ, Lammertsma AA, Law I, Mathews D, Minoshima S, Mosci K, Pagani M, Pappata S, Silverman DH, Signore A, Van De Giessen E, Villemagne V, Barthel H, on behalf of the European Association of Nuclear Medicine (EANM) and of the Society of Nuclear Medicine and Molecular Imaging (SNMMI). The need of standardization and of large clinical studies in an emerging indication of [18F]FDG PET: the autoimmune encephalitis. European Journal Of Nuclear Medicine And Molecular Imaging 2016, 44: 353-357. PMID: 27924371, DOI: 10.1007/s00259-016-3589-9.
- Finnema SJ, Nabulsi NB, Eid T, Detyniecki K, Lin SF, Chen MK, Dhaher R, Matuskey D, Baum E, Holden D, Spencer DD, Mercier J, Hannestad J, Huang Y, Carson RE. Imaging synaptic density in the living human brain. Science Translational Medicine 2016, 8: 348ra96. PMID: 27440727, DOI: 10.1126/scitranslmed.aaf6667.
- Chen MK, Menard DH, Cheng DW. Determining the Minimal Required Radioactivity of 18F-FDG for Reliable Semiquantification in PET/CT Imaging: A Phantom Study. Journal Of Nuclear Medicine Technology 2016, 44: 26-30. PMID: 26769598, DOI: 10.2967/jnmt.115.165258.
- Park E, Gallezot JD, Delgadillo A, Liu S, Planeta B, Lin SF, O’Connor K, Lim K, Lee JY, Chastre A, Chen MK, Seneca N, Leppert D, Huang Y, Carson RE, Pelletier D. 11C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areas. European Journal Of Nuclear Medicine And Molecular Imaging 2015, 42: 1081-1092. PMID: 25833352, DOI: 10.1007/s00259-015-3043-4.
- Chen MK, Cheng DW. What is the role of dosimetry in patients with advanced thyroid cancer? Current Opinion In Oncology 2015, 27: 33-37. PMID: 25319079, DOI: 10.1097/cco.0000000000000145.
- Lin S, Labaree D, Chen M, Holden D, Gallezot J, Kapinos M, Teng J, Najafzadeh S, Plisson C, Rabiner EA, Gunn RN, Carson RE, Huang Y. Further evaluation of [11C]MP‐10 as a radiotracer for phosphodiesterase 10A: PET imaging study in rhesus monkeys and brain tissue metabolite analysis. Synapse 2014, 69: 86-95. PMID: 25450608, PMCID: PMC4275380, DOI: 10.1002/syn.21792.
- Caporizzo DJ, Kwiatkowski AE, Chen MK, Beck AP, Booth CJ, Zeiss C, Smith PC, Carlson Scholz JA, Wilson SR. Use of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography to aid in diagnosing intestinal adenocarcinoma in 2 rhesus macaques (Macaca mulatta). Comparative Medicine 2014, 64: 211-20. PMID: 24956213, PMCID: PMC4067585.
- Chen MK, Yasrebi M, Samii J, Staib LH, Doddamane I, Cheng DW. The Utility of I-123 Pretherapy Scan in I-131 Radioiodine Therapy for Thyroid Cancer. Thyroid 2012, 22: 304-309. PMID: 22300251, DOI: 10.1089/thy.2011.0203.
- Chen MK, Doddamane I, Cheng DW. Recombinant human thyroid-stimulating hormone as an alternative for thyroid hormone withdrawal in thyroid cancer management. Current Opinion In Oncology 2010, 22: 6-10. PMID: 19844179, DOI: 10.1097/cco.0b013e3283339d5d.
- Chen MK, Guilarte TR. Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair. Pharmacology & Therapeutics 2008, 118: 1-17. PMID: 18374421, PMCID: PMC2453598, DOI: 10.1016/j.pharmthera.2007.12.004.
- Chen MK, Kuwabara H, Zhou Y, Adams RJ, Brasić JR, McGlothan JL, Verina T, Burton NC, Alexander M, Kumar A, Wong DF, Guilarte TR. VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease. Journal Of Neurochemistry 2008, 105: 78-90. PMID: 17988241, PMCID: PMC4137401, DOI: 10.1111/j.1471-4159.2007.05108.x.
- Guilarte TR, Chen MK. Manganese inhibits NMDA receptor channel function: implications to psychiatric and cognitive effects. Neurotoxicology 2007, 28: 1147-52. PMID: 17662456, PMCID: PMC2100416, DOI: 10.1016/j.neuro.2007.06.005.
- Guilarte TR, Chen MK, McGlothan JL, Verina T, Wong DF, Zhou Y, Alexander M, Rohde CA, Syversen T, Decamp E, Koser AJ, Fritz S, Gonczi H, Anderson DW, Schneider JS. Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates. Experimental Neurology 2006, 202: 381-90. PMID: 16925997, DOI: 10.1016/j.expneurol.2006.06.015.
- Guilarte TR, McGlothan JL, Degaonkar M, Chen MK, Barker PB, Syversen T, Schneider JS. Evidence for cortical dysfunction and widespread manganese accumulation in the nonhuman primate brain following chronic manganese exposure: a 1H-MRS and MRI study. Toxicological Sciences : An Official Journal Of The Society Of Toxicology 2006, 94: 351-8. PMID: 16968886, DOI: 10.1093/toxsci/kfl106.
- Zhou Y, Chen MK, Endres CJ, Ye W, Brasic JR, Alexander M, Crabb AH, Guilarte TR, Wong DF. An extended simplified reference tissue model for the quantification of dynamic PET with amphetamine challenge. NeuroImage 2006, 33: 550-63. PMID: 16920365, DOI: 10.1016/j.neuroimage.2006.06.038.
- Chen MK, Guilarte TR. Imaging the peripheral benzodiazepine receptor response in central nervous system demyelination and remyelination. Toxicological Sciences : An Official Journal Of The Society Of Toxicology 2006, 91: 532-9. PMID: 16554315, DOI: 10.1093/toxsci/kfj172.
- Acute manganese administration alters dopamine transporter levels in the non-human primate striatum.Chen MK, Lee JS, McGlothan JL, Furukawa E, Adams RJ, Alexander M, Wong DF, Guilarte TR. Acute manganese administration alters dopamine transporter levels in the non-human primate striatum. Neurotoxicology 2006, 27: 229-36. PMID: 16325911, DOI: 10.1016/j.neuro.2005.10.008.
- Hardwick MJ, Chen MK, Baidoo K, Pomper MG, Guilarte TR. In vivo imaging of peripheral benzodiazepine receptors in mouse lungs: a biomarker of inflammation. Molecular Imaging 2005, 4: 432-8. PMID: 16285905.
- Lin KS, Luu A, Baidoo KE, Hashemzadeh-Gargari H, Chen MK, Brenneman K, Pili R, Pomper M, Carducci MA, Wagner HN. A new high affinity technetium-99m-bombesin analogue with low abdominal accumulation. Bioconjugate Chemistry 2005, 16: 43-50. PMID: 15656574, DOI: 10.1021/bc049820h.
- Lin KS, Luu A, Baidoo KE, Hashemzadeh-Gargari H, Chen MK, Pili R, Pomper M, Carducci M, Wagner HN. A new high affinity technetium analogue of bombesin containing DTPA as a pharmacokinetic modifier. Bioconjugate Chemistry 2004, 15: 1416-23. PMID: 15546210, DOI: 10.1021/bc0498267.
- Chen MK, Baidoo K, Verina T, Guilarte TR. Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization. Brain : A Journal Of Neurology 2004, 127: 1379-92. PMID: 15069023, DOI: 10.1093/brain/awh161.
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Nuclear Medicine
Yale New Haven Hospital
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New Haven, CT 06510
- Nuclear MedicineYale New Haven Hospital20 York Street, Ste 2nd FloorNew Haven, CT 06510
Nuclear Medicine
Yale New Haven Hospital
20 York Street, Ste 2nd Floor
New Haven, CT 06510
- Nuclear MedicineYale New Haven Hospital20 York Street, Ste 2nd FloorNew Haven, CT 06510