John Krystal, MD
Psychiatry, Addiction Medicine
Biography
John Krystal, MD, is a leading expert in the areas of alcoholism, post-traumatic stress disorder, schizophrenia, and depression. His work links psychopharmacology, neuroimaging, molecular genetics, and computational neuroscience to study the neurobiology and treatment of these disorders. He is best known for leading the discovery of the rapid antidepressant effects of ketamine in depressed patients.
He is a member of the U.S. National Academy of Medicine. He also serves in a variety of advisory and review capacities for NIAAA, NIMH, Wellcome Trust, Brain and Behavior Research Foundation, the Broad Institute, and the Karolinska Institutet.
Dr. Krystal previously served on the National Alcohol Abuse and Alcoholism Advisory Council (NIAAA), the Department of Defense Psychological Health Advisory Committee, and the NIMH Board of Scientific Counselors (chair, 2005-2007). He has led the American College of Neuropsychopharmacology (president, 2012), and International College of Neuropsychophamacology (president, 2016-2018).
Currently, he is co-chair of the Neuroscience Forum (NeuroForum) of the National Academies of Sciences, Engineering, and Medicine, a member of the NIMH National Mental Health Advisory Council, and he edits the journal, Biological Psychiatry (impact factor: 11.982).
Titles
- Robert L. McNeil, Jr. Professor of Translational Research and Professor of Psychiatry, of Neuroscience, and of Psychology
- Co-Director, Yale Center for Clinical Investigation
- Chair, Psychiatry
- Physician-in-Chief of Psychiatry, Yale New Haven Hospital
- Director: NIAAA Center for the Translational Neuroscience of Alcoholism
- Director, Clinical Neuroscience Division, VA National Center for PTSD
Education & Training
- ResidencyYale University School of Medicine (1988)
- MDYale University (1984)
- BAUniversity of Chicago, Behavioral Sciences (1980)
Additional Information
Honors & Recognitions
- Barbara Fish Memorial Award for Contributions to Basic, Translational, and Clinical Neuroscience: American College of Neuropsychopharmacology (2024)
- Rhoda and Bernard Sarnat in International Mental Health Award: National Academy of Medicine (USA) (2023)
- Nasrallah Family Award for Psychiatric Neuroscience: American Psychiatric Association (2023)
- Sir John Gaddam Memorial Lecture and Medal: British Pharmacologic Society (2022)
- Colvin Prize for Outstanding Achievement in Mood Disorders Research: Brain and Behavior Research Foundation (2019)
- Ulf van Euler Memorial Lecturer: Karolinska Institute (2019)
- Edward H. Ahrens, Jr., Distinguished Investigator Award: Association for Clinical and Translational Science (2019)
- E.M. Jellinek Award for Alcohol Research: E.M. Jellinek Foundation (2016)
- Henri Begleiter Award for Research Excellence: Research Society on Alcoholism (2015)
- Paul Hoch Research Award: American Psychopathological Association (2014)
Board Certifications
- AB of Psychiatry & Neurology, Psychiatry (1991)
Professional Service
- Neuroscience Forum, National Academies of Sciences, Engineering, and Medicine (2018 - Present): Co-Director
- International College of Neuropsychopharmacology (2016 - 2018): President
- NIMH (2016 - Present): NIMH National Mental Health Advisory Council
- American College of Neuropsychopharmacology (2011 - 2012): President
Publications
- Harpaz-Rotem *, Duek O, Korem N, Krystal J. MEMORY RELATED STRUCTURAL AND FUNCTIONAL NEURAL CHANGES FOLLOWING A SINGLE INFUSION OF KETAMINE IN PTSD. The International Journal Of Neuropsychopharmacology 2025, 28: i38-i38. PMCID: PMC11814760, DOI: 10.1093/ijnp/pyae059.066.
- Roach B, Ford J, Nicholas S, Ferri J, Gunduz-Bruce H, Krystal J, Jaeger J, Mathalon D. Gamma oscillations and excitation/inhibition imbalance: parallel effects of N-methyl D-aspartate receptor antagonism and psychosis. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 39832734, DOI: 10.1016/j.bpsc.2025.01.008.
- Wolfgang A, Fonzo G, Gray J, Krystal J, Grzenda A, Widge A, Kraguljac N, McDonald W, Rodriguez C, Nemeroff C. MDMA and MDMA-Assisted Therapy. American Journal Of Psychiatry 2024, 182: 79-103. PMID: 39741438, DOI: 10.1176/appi.ajp.20230681.
- Fonzo G, Wolfgang A, Barksdale B, Krystal J, Carpenter L, Kraguljac N, Grzenda A, McDonald W, Widge A, Rodriguez C, Nemeroff C. Psilocybin: From Psychiatric Pariah to Perceived Panacea. American Journal Of Psychiatry 2024, 182: 54-78. PMID: 39741437, PMCID: PMC11694823, DOI: 10.1176/appi.ajp.20230682.
- Fischer I, Na P, Nagamatsu S, Jeste D, Cabrera-Mendoza B, Montalvo-Ortiz J, Krystal J, Polimanti R, Gelernter J, Pietrzak R. Posttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans. JAMA Psychiatry 2024, 81: 1276-1277. PMID: 39476130, PMCID: PMC11581715, DOI: 10.1001/jamapsychiatry.2024.3403.
- Clark S, Hartwell E, Choi D, Krystal J, Messing R, Ferguson L. Next‐generation biomarkers for alcohol consumption and alcohol use disorder diagnosis, prognosis, and treatment: A critical review. Alcohol Clinical And Experimental Research 2024, 49: 5-24. PMID: 39532676, PMCID: PMC11747793, DOI: 10.1111/acer.15476.
- Lamsam L, Gu B, Liang M, Sun G, Khan K, Sheth K, Hirsch L, Pittenger C, Kaye A, Krystal J, Damisah E. The human claustrum tracks slow waves during sleep. Nature Communications 2024, 15: 8964. PMID: 39419999, PMCID: PMC11487173, DOI: 10.1038/s41467-024-53477-x.
- Lee K, Ji J, Fonteneau C, Berkovitch L, Rahmati M, Pan L, Repovš G, Krystal J, Murray J, Anticevic A. Human brain state dynamics are highly reproducible and associated with neural and behavioral features. PLOS Biology 2024, 22: e3002808. PMID: 39316635, PMCID: PMC11421804, DOI: 10.1371/journal.pbio.3002808.
- Ekhtiari H, Zare-Bidoky M, Sangchooli A, Valyan A, Abi-Dargham A, Cannon D, Carter C, Garavan H, George T, Ghobadi-Azbari P, Juchem C, Krystal J, Nichols T, Öngür D, Pernet C, Poldrack R, Thompson P, Paulus M. Reporting checklists in neuroimaging: promoting transparency, replicability, and reproducibility. Neuropsychopharmacology 2024, 50: 67-84. PMID: 39242922, PMCID: PMC11525976, DOI: 10.1038/s41386-024-01973-5.
- Blithikioti C, Duek O, Gordon C, Krystal J, Levy I, Harpaz-Rotem I, Schiller D, Perl O. Cerebellar Contributions to Traumatic Autobiographical Memory in People with Post-Traumatic Stress Disorder. The Cerebellum 2024, 23: 2332-2340. PMID: 39180693, DOI: 10.1007/s12311-024-01731-9.
- Bonomi R, Hillmer A, Woodcock E, Bhatt S, Rusowicz A, Angarita G, Carson R, Davis M, Esterlis I, Nabulsi N, Huang Y, Krystal J, Pietrzak R, Cosgrove K. Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406005121. PMID: 39172786, PMCID: PMC11363315, DOI: 10.1073/pnas.2406005121.
- Petrakis I, Nolen T, Vandergrift N, Hirsch S, Krystal J, De Vivo M, Sabados J, Pisani E, Newcomb J, Kosten T. Dexmedetomidine HCL (BXCL501) as a potential treatment for alcohol use disorder and comorbid PTSD: A phase 1b, placebo‐controlled crossover laboratory study. American Journal On Addictions 2024, 34: 7-14. PMID: 39152094, DOI: 10.1111/ajad.13637.
- Swanberg K, Prinsen H, Averill C, Campos L, Kurada A, Krystal J, Petrakis I, Averill L, Rothman D, Abdallah C, Juchem C. Medial prefrontal cortex neurotransmitter abnormalities in posttraumatic stress disorder with and without comorbidity to major depression. NMR In Biomedicine 2024, 37: e5220. PMID: 39054694, DOI: 10.1002/nbm.5220.
- Averill C, Averill L, Akiki T, Fouda S, Krystal J, Abdallah C. Findings of PTSD-specific deficits in default mode network strength following a mild experimental stressor. NPP—Digital Psychiatry And Neuroscience 2024, 2: 9. PMID: 38919723, PMCID: PMC11197271, DOI: 10.1038/s44277-024-00011-y.
- Blahova Z, Ikezawa S, Falkai P, Krystal J, Rangan T. CONNEX, a Phase III Randomized Trial Program Assessing Efficacy and Safety of Iclepertin in Schizophrenia: Recruitment and Baseline Characteristics. BJPsych Open 2024, 10: s72-s73. PMCID: PMC11738127, DOI: 10.1192/bjo.2024.230.
- Kraguljac N, Bruns D, Appelbaum P, Botello E, King V, Remiszewski N, Widge A, Alpert J, Carpenter L, Grzenda A, Krystal J, McDonald W, Nemeroff C. Post-Roe v Wade psychiatry: legal, clinical, and ethical challenges in psychiatry under abortion bans. The Lancet Psychiatry 2024, 11: 853-862. PMID: 38795722, DOI: 10.1016/s2215-0366(24)00096-8.
- Nunez-Rios D, Hurd Y, Rompala G, Nagamatsu S, Martinez-Magaña J, Krystal J, Group T, Montalvo-Ortiz J. Multi-Omics Mapping in Human Cortical Neurons Reveals Well-Known and Novel Loci of Post-Traumatic Stress Disorder. Biological Psychiatry 2024, 95: s34. DOI: 10.1016/j.biopsych.2024.02.087.
- Martinez-Magaña J, Nagamatsu S, Nunez-Rios D, Krystal J, Girgenti M, Group T, Montalvo-Ortiz J. The Prefrontal Cortex Transcriptomic Landscape of the Comorbidity Between Post-Traumatic Stress Disorder and Opioid Misuse. Biological Psychiatry 2024, 95: s69. DOI: 10.1016/j.biopsych.2024.02.169.
- Moujaes F, Ji J, Rahmati M, Burt J, Schleifer C, Adkinson B, Savic A, Santamauro N, Tamayo Z, Diehl C, Kolobaric A, Flynn M, Rieser N, Fonteneau C, Camarro T, Xu J, Cho Y, Repovs G, Fineberg S, Morgan P, Seifritz E, Vollenweider F, Krystal J, Murray J, Preller K, Anticevic A. Ketamine induces multiple individually distinct whole-brain functional connectivity signatures. ELife 2024, 13: e84173. PMID: 38629811, PMCID: PMC11023699, DOI: 10.7554/elife.84173.
- Na P, Petrakis I, Krystal J, Pietrzak R. Problem Opioid Use Among US Military Veterans: Prevalence, Correlates, and Psychiatric Characteristics. Journal Of Addiction Medicine 2024, 18: 313-318. PMID: 38498625, PMCID: PMC11150085, DOI: 10.1097/adm.0000000000001286.
- Havlik J, Wahid S, Teopiz K, McIntyre R, Krystal J, Rhee T. Recent Advances in the Treatment of Treatment-Resistant Depression: A Narrative Review of Literature Published from 2018 to 2023. Current Psychiatry Reports 2024, 26: 176-213. PMID: 38386251, DOI: 10.1007/s11920-024-01494-4.
- Basu A, Yang J, Yu A, Glaeser-Khan S, Rondeau J, Feng J, Krystal J, Li Y, Kaye A. Frontal Norepinephrine Represents a Threat Prediction Error Under Uncertainty. Biological Psychiatry 2024, 96: 256-267. PMID: 38316333, PMCID: PMC11269024, DOI: 10.1016/j.biopsych.2024.01.025.
- Chekroud A, Hawrilenko M, Loho H, Bondar J, Gueorguieva R, Hasan A, Kambeitz J, Corlett P, Koutsouleris N, Krumholz H, Krystal J, Paulus M. Illusory generalizability of clinical prediction models. Science 2024, 383: 164-167. PMID: 38207039, DOI: 10.1126/science.adg8538.
- Huggins A, Baird C, Briggs M, Laskowitz S, Hussain A, Fouda S, Haswell C, Sun D, Salminen L, Jahanshad N, Thomopoulos S, Veltman D, Frijling J, Olff M, van Zuiden M, Koch S, Nawjin L, Wang L, Zhu Y, Li G, Stein D, Ipser J, Seedat S, du Plessis S, van den Heuvel L, Suarez-Jimenez B, Zhu X, Kim Y, He X, Zilcha-Mano S, Lazarov A, Neria Y, Stevens J, Ressler K, Jovanovic T, van Rooij S, Fani N, Hudson A, Mueller S, Sierk A, Manthey A, Walter H, Daniels J, Schmahl C, Herzog J, Říha P, Rektor I, Lebois L, Kaufman M, Olson E, Baker J, Rosso I, King A, Liberzon I, Angstadt M, Davenport N, Sponheim S, Disner S, Straube T, Hofmann D, Qi R, Lu G, Baugh L, Forster G, Simons R, Simons J, Magnotta V, Fercho K, Maron-Katz A, Etkin A, Cotton A, O’Leary E, Xie H, Wang X, Quidé Y, El-Hage W, Lissek S, Berg H, Bruce S, Cisler J, Ross M, Herringa R, Grupe D, Nitschke J, Davidson R, Larson C, deRoon-Cassini T, Tomas C, Fitzgerald J, Blackford J, Olatunji B, Kremen W, Lyons M, Franz C, Gordon E, May G, Nelson S, Abdallah C, Levy I, Harpaz-Rotem I, Krystal J, Dennis E, Tate D, Cifu D, Walker W, Wilde E, Harding I, Kerestes R, Thompson P, Morey R. Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup. Molecular Psychiatry 2024, 29: 611-623. PMID: 38195980, PMCID: PMC11153161, DOI: 10.1038/s41380-023-02352-0.
- Tamman A, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal J, Gelernter J, Montalvo-Ortiz J, Polimanti R, Pietrzak R. Correction: Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Neuropsychopharmacology 2024, 49: 764-764. PMID: 38182778, PMCID: PMC10876612, DOI: 10.1038/s41386-023-01786-y.
- Krystal J, Imeh I, Garces R, Addy N. The Biological Psychiatry Cover Art Initiative: Addressing the Underrepresentation of Black People on the Journal Cover Through a Series of Commissioned Artworks. Biological Psychiatry 2024, 95: 2. PMID: 38030306, DOI: 10.1016/j.biopsych.2023.10.010.
- Zhou H, Kember R, Deak J, Xu H, Toikumo S, Yuan K, Lind P, Farajzadeh L, Wang L, Hatoum A, Johnson J, Lee H, Mallard T, Xu J, Johnston K, Johnson E, Nielsen T, Galimberti M, Dao C, Levey D, Overstreet C, Byrne E, Gillespie N, Gordon S, Hickie I, Whitfield J, Xu K, Zhao H, Huckins L, Davis L, Sanchez-Roige S, Madden P, Heath A, Medland S, Martin N, Ge T, Smoller J, Hougaard D, Børglum A, Demontis D, Krystal J, Gaziano J, Edenberg H, Agrawal A, Justice A, Stein M, Kranzler H, Gelernter J. Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals. Nature Medicine 2023, 29: 3184-3192. PMID: 38062264, PMCID: PMC10719093, DOI: 10.1038/s41591-023-02653-5.
- Perl O, Duek O, Kulkarni K, Gordon C, Krystal J, Levy I, Harpaz-Rotem I, Schiller D. Neural patterns differentiate traumatic from sad autobiographical memories in PTSD. Nature Neuroscience 2023, 26: 2226-2236. PMID: 38036701, DOI: 10.1038/s41593-023-01483-5.
- Yang J, Huggins A, Sun D, Baird C, Haswell C, Frijling J, Olff M, van Zuiden M, Koch S, Nawijn L, Veltman D, Suarez-Jimenez B, Zhu X, Neria Y, Hudson A, Mueller S, Baker J, Lebois L, Kaufman M, Qi R, Lu G, Říha P, Rektor I, Dennis E, Ching C, Thomopoulos S, Salminen L, Jahanshad N, Thompson P, Stein D, Koopowitz S, Ipser J, Seedat S, du Plessis S, van den Heuvel L, Wang L, Zhu Y, Li G, Sierk A, Manthey A, Walter H, Daniels J, Schmahl C, Herzog J, Liberzon I, King A, Angstadt M, Davenport N, Sponheim S, Disner S, Straube T, Hofmann D, Grupe D, Nitschke J, Davidson R, Larson C, deRoon-Cassini T, Blackford J, Olatunji B, Gordon E, May G, Nelson S, Abdallah C, Levy I, Harpaz-Rotem I, Krystal J, Morey R, Sotiras A. Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods. Neuropsychopharmacology 2023, 49: 609-619. PMID: 38017161, PMCID: PMC10789873, DOI: 10.1038/s41386-023-01763-5.
- Krystal J, Kaye A, Jefferson S, Girgenti M, Wilkinson S, Sanacora G, Esterlis I. Ketamine and the neurobiology of depression: Toward next-generation rapid-acting antidepressant treatments. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2305772120. PMID: 38011560, PMCID: PMC10710048, DOI: 10.1073/pnas.2305772120.
- Ward E, Fragala M, Birse C, Hawrilenko M, Smolka C, Ambwani G, Brown M, Krystal J, Corlett P, Chekroud A. Assessing the impact of a comprehensive mental health program on frontline health service workers. PLOS ONE 2023, 18: e0294414. PMID: 37988363, PMCID: PMC10662717, DOI: 10.1371/journal.pone.0294414.
- Zhu X, Kim Y, Ravid O, He X, Suarez-Jimenez B, Zilcha-Mano S, Lazarov A, Lee S, Abdallah C, Angstadt M, Averill C, Baird C, Baugh L, Blackford J, Bomyea J, Bruce S, Bryant R, Cao Z, Choi K, Cisler J, Cotton A, Daniels J, Davenport N, Davidson R, DeBellis M, Dennis E, Densmore M, deRoon-Cassini T, Disner S, Hage W, Etkin A, Fani N, Fercho K, Fitzgerald J, Forster G, Frijling J, Geuze E, Gonenc A, Gordon E, Gruber S, Grupe D, Guenette J, Haswell C, Herringa R, Herzog J, Hofmann D, Hosseini B, Hudson A, Huggins A, Ipser J, Jahanshad N, Jia-Richards M, Jovanovic T, Kaufman M, Kennis M, King A, Kinzel P, Koch S, Koerte I, Koopowitz S, Korgaonkar M, Krystal J, Lanius R, Larson C, Lebois L, Li G, Liberzon I, Lu G, Luo Y, Magnotta V, Manthey A, Maron-Katz A, May G, McLaughlin K, Mueller S, Nawijn L, Nelson S, Neufeld R, Nitschke J, O'Leary E, Olatunji B, Olff M, Peverill M, Phan K, Qi R, Quidé Y, Rektor I, Ressler K, Riha P, Ross M, Rosso I, Salminen L, Sambrook K, Schmahl C, Shenton M, Sheridan M, Shih C, Sicorello M, Sierk A, Simmons A, Simons R, Simons J, Sponheim S, Stein M, Stein D, Stevens J, Straube T, Sun D, Théberge J, Thompson P, Thomopoulos S, van der Wee N, van der Werff S, van Erp T, van Rooij S, van Zuiden M, Varkevisser T, Veltman D, Vermeiren R, Walter H, Wang L, Wang X, Weis C, Winternitz S, Xie H, Zhu Y, Wall M, Neria Y, Morey R. Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium. NeuroImage 2023, 283: 120412. PMID: 37858907, PMCID: PMC10842116, DOI: 10.1016/j.neuroimage.2023.120412.
- Tamman A, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal J, Gelernter J, Montalvo-Ortiz J, Polimanti R, Pietrzak R. Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Neuropsychopharmacology 2023, 49: 699-708. PMID: 37848731, PMCID: PMC10876568, DOI: 10.1038/s41386-023-01747-5.
- Krystal J, Preller K, Corlett P, Anticevic A, Kaye A. Psychedelics and the Neurobiology of Meaningfulness. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 9: 462-463. PMID: 37730161, DOI: 10.1016/j.bpsc.2023.09.003.
- Na P, Zhou H, Montalvo-Ortiz J, Cabrera-Mendoza B, Petrakis I, Krystal J, Polimanti R, Gelernter J, Pietrzak R. Positive personality traits moderate persistent high alcohol consumption, determined by polygenic risk in U.S. military veterans: results from a 10-year, population-based, observational cohort study. Psychological Medicine 2023, 53: 7893-7901. PMID: 37642191, PMCID: PMC11750353, DOI: 10.1017/s003329172300199x.
- Rompala G, Nagamatsu S, Martínez-Magaña J, Nuñez-Ríos D, Wang J, Girgenti M, Krystal J, Gelernter J, Hurd Y, Montalvo-Ortiz J. Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex. Nature Communications 2023, 14: 4544. PMID: 37507366, PMCID: PMC10382503, DOI: 10.1038/s41467-023-40285-y.
- Krystal J, Kavalali E, Monteggia L. Ketamine and rapid antidepressant action: new treatments and novel synaptic signaling mechanisms. Neuropsychopharmacology 2023, 49: 41-50. PMID: 37488280, PMCID: PMC10700627, DOI: 10.1038/s41386-023-01629-w.
- Benfer N, Grunthal B, Dondanville K, Young-McCaughan S, Blankenship A, Abdallah C, Back S, Flanagan J, Foa E, Fox P, Krystal J, Marx B, McGeary D, McLean C, Pruiksma K, Resick P, Roache J, Shiroma P, Sloan D, Taylor D, Wachen J, López-Roca A, Nicholson K, Schobitz R, Schrader C, Sharrieff A, Yarvis J, Mintz J, Keane T, Peterson A, Litz B. DSM-5 Criterion-A-Based Trauma Types in Service Members and Veterans Seeking Treatment for Posttraumatic Stress Disorder. Psychological Trauma Theory Research Practice And Policy 2023, 16: 1218-1228. PMID: 37410416, PMCID: PMC10770283, DOI: 10.1037/tra0001537.
- Duek O, Korem N, Li Y, Kelmendi B, Amen S, Gordon C, Milne M, Krystal J, Levy I, Harpaz-Rotem I. Long term structural and functional neural changes following a single infusion of Ketamine in PTSD. Neuropsychopharmacology 2023, 48: 1648-1658. PMID: 37270621, PMCID: PMC10517133, DOI: 10.1038/s41386-023-01606-3.
- Fischer I, Nichter B, Na P, Norman S, Krystal J, Pietrzak R. Longitudinal Trends in Suicidal Thoughts and Behaviors Among US Military Veterans During the COVID-19 Pandemic. JAMA Psychiatry 2023, 80: 577-584. PMID: 37017978, PMCID: PMC10077136, DOI: 10.1001/jamapsychiatry.2023.0393.
- Kaye A, Rao M, Kwan A, Ressler K, Krystal J. A computational model for learning from repeated traumatic experiences under uncertainty. Cognitive, Affective, & Behavioral Neuroscience 2023, 23: 894-904. PMID: 37165181, PMCID: PMC11149767, DOI: 10.3758/s13415-023-01085-5.
- Abi-Dargham A, Moeller S, Ali F, DeLorenzo C, Domschke K, Horga G, Jutla A, Kotov R, Paulus M, Rubio J, Sanacora G, Veenstra-VanderWeele J, Krystal J. Candidate biomarkers in psychiatric disorders: state of the field. World Psychiatry 2023, 22: 236-262. PMID: 37159365, PMCID: PMC10168176, DOI: 10.1002/wps.21078.
- Surti T, Ranganathan M, Johannesen J, Gueorguieva R, Deaso E, Kenney J, Krystal J, D'Souza D. Randomized controlled trial of the glycine transporter 1 inhibitor PF-03463275 to enhance cognitive training and neuroplasticity in schizophrenia. Schizophrenia Research 2023, 256: 36-43. PMID: 37141764, PMCID: PMC10257994, DOI: 10.1016/j.schres.2023.04.010.
- Girgenti M, Zhang J, Skarica M, Hwang A, Xu K, Young K, Zhao H, Sestan N, Krystal J. Single Cell Genomic Analysis Reveals Cell Type-Specific Molecular Signatures in the Human PTSD Prefrontal Cortex. Biological Psychiatry 2023, 93: s11-s12. DOI: 10.1016/j.biopsych.2023.02.049.
- Rahmati M, Moujaes F, Schleifer C, Ji J, Fonteneau C, Tamayo Z, Santamauro N, Respov G, Fineberg S, Krystal J, Murray J, Cho Y, Anticevic A. 248. Effects of NMDA Receptor Antagonist Ketamine on Neural Tuning. Biological Psychiatry 2023, 93: s193-s194. DOI: 10.1016/j.biopsych.2023.02.488.
- Driesen N, Herman P, Rowland M, Thompson G, Qiu M, He G, Criscuolo E, Fineberg S, Barron D, Helgeson L, Lacadie C, Chow R, Gueorguieva R, Straun T, Krystal J, Hyder F. 430. Calibrated fMRI Sensitive to Ketamine-Related Increases Throughout the Cortex. Biological Psychiatry 2023, 93: s268-s269. DOI: 10.1016/j.biopsych.2023.02.670.
- Sarantopoulos C, Shin D, Schleifer C, Moujaes F, Adkinson B, Ji J, Kolabaric A, Flynn M, Santamauro N, Krystal J, Murray J, Repovs G, Martin W, Pittenger C, Anticevic A, Cho Y. 511. Common and Distinct Effects of Incentives on Spatial Working Memory in Schizophrenia and Obsessive-Compulsive Disorder. Biological Psychiatry 2023, 93: s300-s301. DOI: 10.1016/j.biopsych.2023.02.751.
- Johnson T, Black S, Smith B, Krystal J, Sevier B, Aly F, Kumpf B, Grover K, Solod A. 183 Explaining Research to Children and Adolescents. Journal Of Clinical And Translational Science 2023, 7: 56-57. PMCID: PMC10129822, DOI: 10.1017/cts.2023.261.
- Johnson T, Davis J, Smith B, Krystal J, Sevier B, Perry L, Clayton E, Black S. 93 Empowering the Next Generation of Clinical & Translational Scientists. Journal Of Clinical And Translational Science 2023, 7: 26-26. PMCID: PMC10129482, DOI: 10.1017/cts.2023.176.
- Shinn M, Hu A, Turner L, Noble S, Preller K, Ji J, Moujaes F, Achard S, Scheinost D, Constable R, Krystal J, Vollenweider F, Lee D, Anticevic A, Bullmore E, Murray J. Functional brain networks reflect spatial and temporal autocorrelation. Nature Neuroscience 2023, 26: 867-878. PMID: 37095399, DOI: 10.1038/s41593-023-01299-3.
- Widge A, Jordan A, Kraguljac N, Sullivan C, Wilson S, Benton T, Alpert J, Carpenter L, Krystal J, Nemeroff C, Dzirasa K. Structural Racism in Psychiatric Research Careers: Eradicating Barriers to a More Diverse Workforce. American Journal Of Psychiatry 2023, 180: 645-659. PMID: 37073513, PMCID: PMC11227892, DOI: 10.1176/appi.ajp.20220685.
- Wunderlich G, Blahova Z, Hake S, Ikezawa S, Marder S, Falkai P, Krystal J. Efficacy and Safety of Iclepertin (BI 425809) in Patients With Schizophrenia: CONNEX, A Phase III Randomized Controlled Trial Program. CNS Spectrums 2023, 28: 229-229. DOI: 10.1017/s1092852923001530.
- Havlik J, Murphy M, Gong N, Tang D, Krystal J. Characteristics of Esketamine Prescribers Among Medicare Beneficiaries in the United States, 2019-2020. JAMA Network Open 2023, 6: e2311250. PMID: 37103934, PMCID: PMC10140803, DOI: 10.1001/jamanetworkopen.2023.11250.
- Jia R, Ruderman L, Pietrzak R, Gordon C, Ehrlich D, Horvath M, Mirchandani S, DeFontes C, Southwick S, Krystal J, Harpaz-Rotem I, Levy I. Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach. Translational Psychiatry 2023, 13: 101. PMID: 36977676, PMCID: PMC10050320, DOI: 10.1038/s41398-023-02388-4.
- Na P, Montalvo-Ortiz J, Petrakis I, Krystal J, Polimanti R, Gelernter J, Pietrzak R. Trajectories of alcohol consumption in U.S. military veterans: Results from a 10-year population-based longitudinal study. Drug And Alcohol Dependence 2023, 246: 109833. PMID: 36963160, PMCID: PMC10811960, DOI: 10.1016/j.drugalcdep.2023.109833.
- Falkai P, Reuteman-Fowler C, Blahova Z, Ikezawa S, Marder S, Krystal J. Efficacy and safety of iclepertin (BI 425809) in patients with schizophrenia: CONNEX, a Phase III randomised controlled trial programme. European Psychiatry 2023, 66: s637-s637. PMCID: PMC10661489, DOI: 10.1192/j.eurpsy.2023.1325.
- Fineberg S, Choi E, Shapiro-Thompson R, Dhaliwal K, Neustadter E, Sakheim M, Null K, Trujillo-Diaz D, Rondeau J, Pittaro G, Peters J, Corlett P, Krystal J. A pilot randomized controlled trial of ketamine in Borderline Personality Disorder. Neuropsychopharmacology 2023, 48: 991-999. PMID: 36804489, PMCID: PMC10209175, DOI: 10.1038/s41386-023-01540-4.
- Núñez-Rios D, Martínez-Magaña J, Nagamatsu S, Krystal J, Martínez-González K, Giusti-Rodríguez P, Montalvo-Ortiz J. Cross-Species Convergence of Brain Transcriptomic and Epigenomic Findings in Posttraumatic Stress Disorder: A Systematic Review. Complex Psychiatry 2023, 9: 100-118. PMID: 37404872, PMCID: PMC10315001, DOI: 10.1159/000529536.
- Fischer I, Na P, Harpaz-Rotem I, Krystal J, Pietrzak R. Characterization of Mental Health in US Veterans Before, During, and 2 Years After the Onset of the COVID-19 Pandemic. JAMA Network Open 2023, 6: e230463. PMID: 36821116, PMCID: PMC9951035, DOI: 10.1001/jamanetworkopen.2023.0463.
- Nagamatsu S, Rompala G, Hurd Y, Núñez-Rios D, Montalvo-Ortiz J, Group T, Alvarez V, Benedek D, Che A, Cruz D, Davis D, Girgenti M, Hoffman E, Holtzheimer P, Huber B, Kaye A, Krystal J, Labadorf A, Keane T, Logue M, McKee A, Marx B, Mash D, Miller M, Noller C, JM-O, Scott W, Schnurr P, Stein T, Ursano R, Williamson D, Wolf E, Young K. CpH methylome analysis in human cortical neurons identifies novel gene pathways and drug targets for opioid use disorder. Frontiers In Psychiatry 2023, 13: 1078894. PMID: 36745154, PMCID: PMC9892724, DOI: 10.3389/fpsyt.2022.1078894.
- Stanley I, Marx B, Fina B, Young-McCaughan S, Tyler H, Sloan D, Blankenship A, Dondanville K, Walker J, Boffa J, Bryan C, Brown L, Straud C, Mintz J, Abdallah C, Back S, Blount T, DeBeer B, Flanagan J, Foa E, Fox P, Fredman S, Krystal J, McDevitt-Murphy M, McGeary D, Pruiksma K, Resick P, Roache J, Shiroma P, Taylor D, Wachen J, Kaplan A, López-Roca A, Nicholson K, Schobitz R, Schrader C, Sharrieff A, Yarvis J, Litz B, Keane T, Peterson A. Psychometric Properties of the Self-Injurious Thoughts and Behaviors Interview–Short Form Among U.S. Active Duty Military Service Members and Veterans. Assessment 2023, 30: 2332-2346. PMID: 36644835, DOI: 10.1177/10731911221143979.
- Reuteman-Fowler C, Blahova Z, Ikezawa S, Marder S, Falkai P, Krystal J. Efficacy and safety of iclepertin (BI 425809) in patients with schizophrenia: CONNEX, a Phase III randomised controlled trial programme. Neuroscience Applied 2023, 2: 102592. DOI: 10.1016/j.nsa.2023.102592.
- Rhee TG, Shim SR, Forester BP, Nierenberg AA, McIntyre RS, Papakostas GI, Krystal JH, Sanacora G, Wilkinson ST. Efficacy and Safety of Ketamine vs Electroconvulsive Therapy Among Patients With Major Depressive Episode. JAMA Psychiatry 2022, 79: 1162-1172. PMID: 36260324, PMCID: PMC9582972, DOI: 10.1001/jamapsychiatry.2022.3352.
- Krystal J, Kane J, Correll C, Walling D, Leoni M, Duvvuri S, Patel S, Chang I, Iredale P, Frohlich L, Versavel S, Perry P, Sanchez R, Renger J. Emraclidine, a novel positive allosteric modulator of cholinergic M4 receptors, for the treatment of schizophrenia: a two-part, randomised, double-blind, placebo-controlled, phase 1b trial. The Lancet 2022, 400: 2210-2220. PMID: 36528376, DOI: 10.1016/s0140-6736(22)01990-0.
- Nagamatsu S, Pietrzak R, Xu K, Krystal J, Gelernter J, Montalvo‐Ortiz J. Dissecting the epigenomic differences between smoking and nicotine dependence in a veteran cohort. Addiction Biology 2022, 28: e13259. PMID: 36577721, DOI: 10.1111/adb.13259.
- Nichter B, Koller D, De Angelis F, Wang J, Girgenti M, Na P, Hill M, Norman S, Krystal J, Gelernter J, Polimanti R, Pietrzak R. Genetic liability to suicidal thoughts and behaviors and risk of suicide attempt in US military veterans: moderating effects of cumulative trauma burden. Psychological Medicine 2022, 53: 6325-6333. PMID: 36444557, DOI: 10.1017/s0033291722003646.
- Merians A, Spiller T, Harpaz-Rotem I, Krystal J, Pietrzak R. Post-traumatic Stress Disorder. Medical Clinics Of North America 2022, 107: 85-99. PMID: 36402502, DOI: 10.1016/j.mcna.2022.04.003.
- Harvey PD, Depp CA, Rizzo AA, Strauss GP, Spelber D, Carpenter LL, Kalin NH, Krystal JH, McDonald WM, Nemeroff CB, Rodriguez CI, Widge AS, Torous J. Technology and Mental Health: State of the Art for Assessment and Treatment. American Journal Of Psychiatry 2022, 179: 897-914. PMID: 36200275, DOI: 10.1176/appi.ajp.21121254.
- Citrome L, Preskorn SH, Lauriello J, Krystal JH, Kakar R, Finman J, De Vivo M, Yocca FD, Risinger R, Rajachandran L. Sublingual Dexmedetomidine for the Treatment of Acute Agitation in Adults With Schizophrenia or Schizoaffective Disorder: A Randomized Placebo-Controlled Trial. The Journal Of Clinical Psychiatry 2022, 83 PMID: 36198061, DOI: 10.4088/jcp.22m14447.
- Tamman AJF, Nagamatsu S, Krystal JH, Gelernter J, Montalvo-Ortiz JL, Pietrzak RH. Psychosocial Factors Associated With Accelerated GrimAge in Male U.S. Military Veterans. American Journal Of Geriatric Psychiatry 2022, 31: 97-109. PMID: 36210262, DOI: 10.1016/j.jagp.2022.09.002.
- Olson K, Fogelman N, Maturo L, Alvarado J, Ball S, Forray A, Hu M, Ivy M, Kapo J, Krystal J, Mayes L, Rohrbaugh R, Southwick S, Tebes J, Wassel B, Sinha R. COVID-19 Traumatic Disaster Appraisal and Stress Symptoms Among Health Care Workers. Journal Of Occupational And Environmental Medicine 2022, 64: 934-941. PMID: 35959912, PMCID: PMC9640251, DOI: 10.1097/jom.0000000000002673.
- Wendt FR, Pathak GA, Singh K, Stein MB, Koenen KC, Krystal JH, Gelernter J, Davis LK, Polimanti R. Sex-Specific Genetic and Transcriptomic Liability to Neuroticism. Biological Psychiatry 2022, 93: 243-252. PMID: 36244801, PMCID: PMC10508260, DOI: 10.1016/j.biopsych.2022.07.019.
- Jegede O, Na PJ, Haeny AM, Krystal JH, Pietrzak RH. Association of Distress Due to Systemic Racism and Racial Disparities With Psychopathology and Suicidal Ideation Among US Veterans During the COVID-19 Pandemic. The Journal Of Clinical Psychiatry 2022, 83 PMID: 35921504, PMCID: PMC10228546, DOI: 10.4088/jcp.22br14410.
- Sun D, Rakesh G, Haswell CC, Logue M, Baird CL, O'Leary EN, Cotton AS, Xie H, Tamburrino M, Chen T, Dennis EL, Jahanshad N, Salminen LE, Thomopoulos SI, Rashid F, Ching CRK, Koch SBJ, Frijling JL, Nawijn L, van Zuiden M, Zhu X, Suarez-Jimenez B, Sierk A, Walter H, Manthey A, Stevens JS, Fani N, van Rooij SJH, Stein M, Bomyea J, Koerte IK, Choi K, van der Werff SJA, Vermeiren RRJM, Herzog J, Lebois LAM, Baker JT, Olson EA, Straube T, Korgaonkar MS, Andrew E, Zhu Y, Li G, Ipser J, Hudson AR, Peverill M, Sambrook K, Gordon E, Baugh L, Forster G, Simons RM, Simons JS, Magnotta V, Maron-Katz A, du Plessis S, Disner SG, Davenport N, Grupe DW, Nitschke JB, deRoon-Cassini TA, Fitzgerald JM, Krystal JH, Levy I, Olff M, Veltman DJ, Wang L, Neria Y, De Bellis MD, Jovanovic T, Daniels JK, Shenton M, van de Wee NJA, Schmahl C, Kaufman ML, Rosso IM, Sponheim SR, Hofmann DB, Bryant RA, Fercho KA, Stein DJ, Mueller SC, Hosseini B, Phan KL, McLaughlin KA, Davidson RJ, Larson CL, May G, Nelson SM, Abdallah CG, Gomaa H, Etkin A, Seedat S, Harpaz-Rotem I, Liberzon I, van Erp TGM, Quidé Y, Wang X, Thompson PM, Morey RA. A comparison of methods to harmonize cortical thickness measurements across scanners and sites. NeuroImage 2022, 261: 119509. PMID: 35917919, PMCID: PMC9648725, DOI: 10.1016/j.neuroimage.2022.119509.
- Na PJ, Montalvo-Ortiz JL, Nagamatsu ST, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. Association of Symptoms of Posttraumatic Stress Disorder and GrimAge, an Epigenetic Marker of Mortality Risk, in US Military Veterans. The Journal Of Clinical Psychiatry 2022, 83 PMID: 35802930, PMCID: PMC10859885, DOI: 10.4088/jcp.21br14309.
- Kohler C, Wolf D, Abi-Dargham A, Anticevic A, Cho Y, Fonteneau C, Gil R, Girgis R, Gray D, Grinband J, Javitch J, Kantrowitz J, Krystal J, Lieberman J, Murray J, Ranganathan M, Santamauro N, Van Snellenberg J, Tamayo Z, Group T, D'Souza D, Srihari V, Gueorguieva R, Patel P, Forselius-Bielen K, Lu J, Butler A, Fram G, Afriyie-Agyemang Y, Selloni A, Cadavid L, Gomez-Luna S, Gupta A, Radhakrishnan R, Rashid A, Aker R, Abrahim P, Nia A, Surti T, Kegeles L, Carlson M, Goldberg T, Gangwisch J, Benedict E, Govil P, Brazis S, Mayer M, de la Garrigue N, Fallon N, Baumvoll T, Abeykoon S, Perlman G, Bobchin K, Elliott M, Schmidt L, Rush S, Port A, Heffernan Z, Laney N, Kantor J, Hohing T, Gur R, Gur R, Calkins M. Illness Phase as a Key Assessment and Intervention Window for Psychosis. Biological Psychiatry Global Open Science 2022, 3: 340-350. PMID: 37519466, PMCID: PMC10382701, DOI: 10.1016/j.bpsgos.2022.05.009.
- Bondar J, Morrow C, Gueorguieva R, Brown M, Hawrilenko M, Krystal JH, Corlett PR, Chekroud AM. Clinical and Financial Outcomes Associated With a Workplace Mental Health Program Before and During the COVID-19 Pandemic. JAMA Network Open 2022, 5: e2216349. PMID: 35679044, PMCID: PMC9185188, DOI: 10.1001/jamanetworkopen.2022.16349.
- Abdallah CG, Roache JD, Gueorguieva R, Averill LA, Young-McCaughan S, Shiroma PR, Purohit P, Brundige A, Murff W, Ahn KH, Sherif MA, Baltutis EJ, Ranganathan M, D’Souza D, Martini B, Southwick SM, Petrakis IL, Burson RR, Guthmiller KB, López-Roca AL, Lautenschlager KA, McCallin JP, Hoch MB, Timchenko A, Souza SE, Bryant CE, Mintz J, Litz BT, Williamson DE, Keane TM, Peterson AL, Krystal JH. Correction to: Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial. Neuropsychopharmacology 2022, 47: 1583-1584. PMID: 35545665, PMCID: PMC9205895, DOI: 10.1038/s41386-022-01339-9.
- Nagamatsu S, Pietrzak R, Na P, Krystal J, Gelernter J, Montalvo-Ortiz J. P79. Are Positive Psychosocial Traits Linked to Epigenetic Aging? Results From a National Sample of U.S. Military Veterans. Biological Psychiatry 2022, 91: s119. DOI: 10.1016/j.biopsych.2022.02.313.
- Nunez-Rios D, Rompala G, Hurd Y, Nagamatsu S, Martinez-Magaña J, Krystal J, Gelernter J, Montalvo-Ortiz T. P630. Multiomics Mapping of Posttraumatic Stress Disorder in Human Cortical Neurons. Biological Psychiatry 2022, 91: s344. DOI: 10.1016/j.biopsych.2022.02.867.
- Shaikh N, Sandhu M, Aljishi A, Obaid S, Gu B, Krystal J, Kaye A, Damisah E. P142. Neural Correlates of Bodily Feedback During Spatial Threat Avoidance. Biological Psychiatry 2022, 91: s144. DOI: 10.1016/j.biopsych.2022.02.376.
- Aljishi A, Sandhu M, Shaikh N, Wise T, Krystal J, Kaye A, Damisah E. P143. Intracranial Electrophysiology of Amygdala-Insula Interactions in Anxiety. Biological Psychiatry 2022, 91: s144-s145. DOI: 10.1016/j.biopsych.2022.02.377.
- Tebes JK, Awad MN, Connors EH, Fineberg SK, Gordon DM, Jordan A, Kravitz R, Li L, Ponce AN, Prabhu M, Rubman S, Silva MA, Steinfeld M, Tate DC, Xu K, Krystal JH. The Stress and Resilience Town Hall: A systems response to support the health workforce during COVID-19 and beyond. General Hospital Psychiatry 2022, 77: 80-87. PMID: 35569322, PMCID: PMC9033303, DOI: 10.1016/j.genhosppsych.2022.04.009.
- Swanberg K, Prinsen H, Averill C, Campos L, Kurada A, Krystal J, Petrakis I, Averill L, Abdallah C, Juchem C. Abnormal glutamate metabolism in prefrontal cortex of post-traumatic stress disorder linked to comorbidity with major depression. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2022 DOI: 10.58530/2022/3344.
- Smart K, Worhunsky PD, Scheinost D, Angarita GA, Esterlis I, Carson RE, Krystal JH, O'Malley SS, Cosgrove KP, Hillmer AT. Multimodal neuroimaging of metabotropic glutamate 5 receptors and functional connectivity in alcohol use disorder. Alcohol Clinical And Experimental Research 2022, 46: 770-782. PMID: 35342968, PMCID: PMC9117461, DOI: 10.1111/acer.14816.
- Nikayin S, Murphy E, Krystal JH, Wilkinson ST. Long-term safety of ketamine and esketamine in treatment of depression. Expert Opinion On Drug Safety 2022, 21: 777-787. PMID: 35416105, DOI: 10.1080/14740338.2022.2066651.
- Abram SV, Roach BJ, Fryer SL, Calhoun VD, Preda A, van Erp TGM, Bustillo JR, Lim KO, Loewy RL, Stuart BK, Krystal JH, Ford JM, Mathalon DH. Validation of ketamine as a pharmacological model of thalamic dysconnectivity across the illness course of schizophrenia. Molecular Psychiatry 2022, 27: 2448-2456. PMID: 35422467, PMCID: PMC9135621, DOI: 10.1038/s41380-022-01502-0.
- Krystal JH, Southwick SM, Girgenti MJ. Matthew J. Friedman, M.D., Ph.D. and His Legacy of Leadership in the Field of Post-traumatic Stress Disorder. Psychiatry 2022, 85: 161-170. PMID: 35588483, DOI: 10.1080/00332747.2022.2068931.
- Cho YT, Moujaes F, Schleifer CH, Starc M, Ji JL, Santamauro N, Adkinson B, Kolobaric A, Flynn M, Krystal JH, Murray JD, Repovs G, Anticevic A. Reward and loss incentives improve spatial working memory by shaping trial-by-trial posterior frontoparietal signals. NeuroImage 2022, 254: 119139. PMID: 35346841, PMCID: PMC9264479, DOI: 10.1016/j.neuroimage.2022.119139.
- Sun D, Rakesh G, Clarke-Rubright EK, Haswell CC, Logue MW, O'Leary EN, Cotton AS, Xie H, Dennis EL, Jahanshad N, Salminen LE, Thomopoulos SI, Rashid FM, Ching CRK, Koch SBJ, Frijling JL, Nawijn L, van Zuiden M, Zhu X, Suarez-Jimenez B, Sierk A, Walter H, Manthey A, Stevens JS, Fani N, van Rooij SJH, Stein MB, Bomyea J, Koerte I, Choi K, van der Werff SJA, Vermeiren RRJM, Herzog JI, Lebois LAM, Baker JT, Ressler KJ, Olson EA, Straube T, Korgaonkar MS, Andrew E, Zhu Y, Li G, Ipser J, Hudson AR, Peverill M, Sambrook K, Gordon E, Baugh LA, Forster G, Simons RM, Simons JS, Magnotta VA, Maron-Katz A, du Plessis S, Disner SG, Davenport ND, Grupe D, Nitschke JB, deRoon-Cassini TA, Fitzgerald J, Krystal JH, Levy I, Olff M, Veltman DJ, Wang L, Neria Y, De Bellis MD, Jovanovic T, Daniels JK, Shenton ME, van de Wee NJA, Schmahl C, Kaufman ML, Rosso IM, Sponheim SR, Hofmann DB, Bryant RA, Fercho KA, Stein DJ, Mueller SC, Phan KL, McLaughlin KA, Davidson RJ, Larson C, May G, Nelson SM, Abdallah CG, Gomaa H, Etkin A, Seedat S, Harpaz-Rotem I, Liberzon I, Wang X, Thompson PM, Morey RA. Remodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results From the ENIGMA-PGC Posttraumatic Stress Disorder Consortium. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2022, 7: 935-948. PMID: 35307575, PMCID: PMC9835553, DOI: 10.1016/j.bpsc.2022.02.008.
- Bonomi R, Girgenti M, Krystal J, Cosgrove K. A Role for Histone Deacetylases in the Biology and Treatment of Post-Traumatic Stress Disorder: What Do We Know and Where Do We Go from Here? Complex Psychiatry 2022, 8: 13-27. PMID: 36545044, PMCID: PMC9669946, DOI: 10.1159/000524079.
- Pathak GA, Singh K, Wendt FR, Fleming TW, Overstreet C, Koller D, Tylee DS, De Angelis F, Cabrera Mendoza B, Levey DF, Koenen KC, Krystal JH, Pietrzak RH, O’ Donell C, Gaziano JM, Falcone G, Stein MB, Gelernter J, Pasaniuc B, Mancuso N, Davis LK, Polimanti R. Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits. Molecular Psychiatry 2022, 27: 1394-1404. PMID: 35241783, PMCID: PMC9210390, DOI: 10.1038/s41380-022-01488-9.
- Wisco BE, Nomamiukor FO, Marx BP, Krystal JH, Southwick SM, Pietrzak RH. Posttraumatic Stress Disorder in US Military Veterans: Results From the 2019-2020 National Health and Resilience in Veterans Study. The Journal Of Clinical Psychiatry 2022, 83 PMID: 35192748, DOI: 10.4088/jcp.20m14029.
- Wendt FR, Warrier V, Pathak GA, Koenen KC, Stein MB, Krystal JH, Pietrzak RH, Gelernter J, Goldfarb EV, Baron-Cohen S, Polimanti R. Polygenic scores for empathy associate with posttraumatic stress severity in response to certain traumatic events. Neurobiology Of Stress 2022, 17: 100439. PMID: 35242894, PMCID: PMC8881478, DOI: 10.1016/j.ynstr.2022.100439.
- Montalvo-Ortiz JL, Gelernter J, Cheng Z, Girgenti MJ, Xu K, Zhang X, Gopalan S, Zhou H, Duman RS, Southwick SM, Krystal JH, Pietrzak R. Epigenome-wide association study of posttraumatic stress disorder identifies novel loci in U.S. military veterans. Translational Psychiatry 2022, 12: 65. PMID: 35177594, PMCID: PMC8854688, DOI: 10.1038/s41398-022-01822-3.
- Holmes SE, Finnema SJ, Naganawa M, DellaGioia N, Holden D, Fowles K, Davis M, Ropchan J, Emory P, Ye Y, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Imaging the effect of ketamine on synaptic density (SV2A) in the living brain. Molecular Psychiatry 2022, 27: 2273-2281. PMID: 35165397, PMCID: PMC9133063, DOI: 10.1038/s41380-022-01465-2.
- Krystal J. Edward F. Domino, Ph.D. (1924–2021). Neuropsychopharmacology 2022, 47: 1138-1139. PMCID: PMC8938419, DOI: 10.1038/s41386-022-01280-x.
- Averill LA, Averill CL, Gueorguieva R, Fouda S, Sherif M, Ahn KH, Ranganathan M, D'Souza DC, Southwick SM, Sanacora G, Duman RS, Krystal JH, Abdallah CG. mTORC1 inhibitor effects on rapid ketamine-induced reductions in suicidal ideation in patients with treatment-resistant depression. Journal Of Affective Disorders 2022, 303: 91-97. PMID: 35101523, DOI: 10.1016/j.jad.2022.01.104.
- Abdallah CG, Roache JD, Gueorguieva R, Averill LA, Young-McCaughan S, Shiroma PR, Purohit P, Brundige A, Murff W, Ahn KH, Sherif MA, Baltutis EJ, Ranganathan M, D’Souza D, Martini B, Southwick SM, Petrakis IL, Burson RR, Guthmiller KB, López-Roca AL, Lautenschlager KA, McCallin JP, Hoch MB, Timchenko A, Souza SE, Bryant CE, Mintz J, Litz BT, Williamson DE, Keane TM, Peterson AL, Krystal JH. Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial. Neuropsychopharmacology 2022, 47: 1574-1581. PMID: 35046508, PMCID: PMC8767037, DOI: 10.1038/s41386-022-01266-9.
- Barron D, Heisig S, Agurto C, Norel R, Quagan B, Powers A, Birnbaum M, Constable T, Cecchi G, Krystal J. Feasibility Analysis of Phenotype Quantification from Unstructured Clinical Interactions. Computational Psychiatry 2022, 6: 1. PMID: 38774775, PMCID: PMC11104416, DOI: 10.5334/cpsy.78.
- Averill LA, Jiang L, Purohit P, Coppoli A, Averill CL, Roscoe J, Kelmendi B, De Feyter HM, de Graaf RA, Gueorguieva R, Sanacora G, Krystal JH, Rothman DL, Mason GF, Abdallah CG. Prefrontal Glutamate Neurotransmission in PTSD: A Novel Approach to Estimate Synaptic Strength in Vivo in Humans. Chronic Stress 2022, 6: 24705470221092734. PMID: 35434443, PMCID: PMC9008809, DOI: 10.1177/24705470221092734.
- Wunderlich G, Blahova Z, Hake S, Ikezawa S, Marder S, Falkai P, Krystal J. Efficacy and safety of BI 425809 in patients with schizophrenia: CONNEX, a Phase III randomised controlled trial programme. Neuroscience Applied 2022, 1: 100342. DOI: 10.1016/j.nsa.2022.100342.
- Clausen AN, Fercho KA, Monsour M, Disner S, Salminen L, Haswell CC, Rubright EC, Watts AA, Buckley MN, Maron-Katz A, Sierk A, Manthey A, Suarez-Jimenez B, Olatunji BO, Averill CL, Hofmann D, Veltman DJ, Olson EA, Li G, Forster GL, Walter H, Fitzgerald J, Théberge J, Simons JS, Bomyea JA, Frijling JL, Krystal JH, Baker JT, Phan KL, Ressler K, Han LKM, Nawijn L, Lebois LAM, Schmaal L, Densmore M, Shenton ME, van Zuiden M, Stein M, Fani N, Simons RM, Neufeld RWJ, Lanius R, van Rooij S, Koch SBJ, Bonomo S, Jovanovic T, deRoon-Cassini T, Ely TD, Magnotta VA, He X, Abdallah CG, Etkin A, Schmahl C, Larson C, Rosso IM, Blackford JU, Stevens JS, Daniels JK, Herzog J, Kaufman ML, Olff M, Davidson RJ, Sponheim SR, Mueller SC, Straube T, Zhu X, Neria Y, Baugh LA, Cole JH, Thompson PM, Morey RA. Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups. Brain And Behavior 2021, 12: e2413. PMID: 34907666, PMCID: PMC8785613, DOI: 10.1002/brb3.2413.
- Lam NH, Borduqui T, Hallak J, Roque A, Anticevic A, Krystal JH, Wang XJ, Murray JD. Effects of Altered Excitation-Inhibition Balance on Decision Making in a Cortical Circuit Model. Journal Of Neuroscience 2021, 42: 1035-1053. PMID: 34887320, PMCID: PMC8824494, DOI: 10.1523/jneurosci.1371-20.2021.
- Hill KP, Gold MS, Nemeroff CB, McDonald W, Grzenda A, Widge AS, Rodriguez C, Kraguljac NV, Krystal JH, Carpenter LL. Risks and Benefits of Cannabis and Cannabinoids in Psychiatry. American Journal Of Psychiatry 2021, 179: 98-109. PMID: 34875873, DOI: 10.1176/appi.ajp.2021.21030320.
- Nichter B, Stein MB, Monteith LL, Herzog S, Holliday R, Hill ML, Norman SB, Krystal JH, Pietrzak RH. Risk factors for suicide attempts among U.S. military veterans: A 7‐year population‐based, longitudinal cohort study. Suicide And Life-Threatening Behavior 2021, 52: 303-316. PMID: 34873738, DOI: 10.1111/sltb.12822.
- DeMartini KS, Gueorguieva R, Taylor JR, Krishnan-Sarin S, Pearlson G, Krystal JH, O'Malley SS. Dynamic structural equation modeling of the relationship between alcohol habit and drinking variability. Drug And Alcohol Dependence 2021, 233: 109202. PMID: 35151022, PMCID: PMC10046111, DOI: 10.1016/j.drugalcdep.2021.109202.
- Kachadourian L, Tsai J, Na PJ, Krystal JH, Southwick SM, Pietrzak RH. Resilience in the Face of the COVID-19 Pandemic: A National Study of US Military Veterans. The Primary Care Companion For CNS Disorders 2021, 23 PMID: 34763375, DOI: 10.4088/pcc.21br03075.
- Na PJ, De Angelis F, Nichter B, Wendt FR, Krystal JH, Southwick SM, Levey DF, Gelernter J, Polimanti R, Pietrzak RH. Psychosocial moderators of polygenic risk for suicidal ideation: Results from a 7-year population-based, prospective cohort study of U.S. veterans. Molecular Psychiatry 2021, 27: 1068-1074. PMID: 34725455, DOI: 10.1038/s41380-021-01352-2.
- Nichter B, Hill ML, Na PJ, Kline AC, Norman SB, Krystal JH, Southwick SM, Pietrzak RH. Prevalence and Trends in Suicidal Behavior Among US Military Veterans During the COVID-19 Pandemic. JAMA Psychiatry 2021, 78: 1218-1227. PMID: 34431973, PMCID: PMC8387942, DOI: 10.1001/jamapsychiatry.2021.2332.
- Krystal J. Potential Schizophrenia Medications Point to New Disease Model. Psychiatric News 2021, 56 DOI: 10.1176/appi.pn.2021.11.37.
- Bhatt S, Hillmer AT, Rusowicz A, Nabulsi N, Matuskey D, Angarita GA, Najafzadeh S, Kapinos M, Southwick SM, Krystal JH, Carson RE, Huang Y, Cosgrove KP. Imaging brain cortisol regulation in PTSD with a target for 11β-hydroxysteroid dehydrogenase type 1. Journal Of Clinical Investigation 2021, 131: e150452. PMID: 34651587, PMCID: PMC8516462, DOI: 10.1172/jci150452.
- Tamman AJF, Wendt FR, Pathak GA, Krystal JH, Southwick SM, Sippel LM, Gelernter J, Polimanti R, Pietrzak RH. Attachment Style Moderates Polygenic Risk for Incident Posttraumatic Stress in U.S. Military Veterans: A 7-Year, Nationally Representative, Prospective Cohort Study. Biological Psychiatry 2021, 91: 637-646. PMID: 34955171, DOI: 10.1016/j.biopsych.2021.09.025.
- Peterson AL, Young-McCaughan S, Roache JD, Mintz J, Litz BT, Williamson DE, Resick PA, Foa EB, McGeary DD, Dondanville KA, Taylor DJ, Wachen JS, Fox PT, Bryan CJ, McLean CP, Pruiksma KE, Yarvis JS, Niles BL, Abdallah CG, Averill LA, Back SE, Baker MT, Blount TH, Borah AM, Borah EV, Brock MS, Brown LA, Burg MM, Cigrang JA, DeBeer BB, DeVoe ER, Fina BA, Flanagan JC, Fredman SJ, Gardner CL, Gatchel RR, Goodie JL, Gueorguieva R, Higgs JB, Jacoby VM, Kelly KM, Krystal JH, Lapiz-Bluhm MD, López-Roca AL, Marx BP, Maurer DM, McDevitt-Murphy ME, McGeary CA, Meyer EC, Miles SR, Monson CM, Morilak DA, Moring JC, Mysliwiec V, Nicholson KL, Rauch SAM, Riggs DS, Rosen CS, Rudd MD, Schobitz RP, Schrader CC, Shinn AM, Shiroma PR, Sloan DM, Stern SL, Strong R, Vannoy SD, Young KA, Keane TM. STRONG STAR and the Consortium to Alleviate PTSD: Shaping the future of combat PTSD and related conditions in military and veteran populations. Contemporary Clinical Trials 2021, 110: 106583. PMID: 34600107, PMCID: PMC11392039, DOI: 10.1016/j.cct.2021.106583.
- Barron DS, Baker JT, Budde KS, Bzdok D, Eickhoff SB, Friston KJ, Fox PT, Geha P, Heisig S, Holmes A, Onnela JP, Powers A, Silbersweig D, Krystal JH. Decision Models and Technology Can Help Psychiatry Develop Biomarkers. Frontiers In Psychiatry 2021, 12: 706655. PMID: 34566711, PMCID: PMC8458705, DOI: 10.3389/fpsyt.2021.706655.
- Patel KT, Stevens MC, Dunlap A, Gallagher A, O’Malley S, DeMartini K, Potenza MN, Krystal JH, Pearlson GD. Effects of the Fyn kinase inhibitor saracatinib on ventral striatal activity during performance of an fMRI monetary incentive delay task in individuals family history positive or negative for alcohol use disorder. A pilot randomised trial. Neuropsychopharmacology 2021, 47: 840-846. PMID: 34475522, PMCID: PMC8882177, DOI: 10.1038/s41386-021-01157-5.
- Thompson SL, Gianessi CA, O'Malley SS, Cavallo DA, Shi JM, Tetrault JM, DeMartini KS, Gueorguieva R, Pittman B, Krystal JH, Taylor JR, Krishnan-Sarin S. Saracatinib Fails to Reduce Alcohol-Seeking and Consumption in Mice and Human Participants. Frontiers In Psychiatry 2021, 12: 709559. PMID: 34531767, PMCID: PMC8438169, DOI: 10.3389/fpsyt.2021.709559.
- Abi-Dargham A, Javitch JA, Slifstein M, Anticevic A, Calkins ME, Cho YT, Fonteneau C, Gil R, Girgis R, Gur RE, Gur RC, Grinband J, Kantrowitz J, Kohler C, Krystal J, Murray J, Ranganathan M, Santamauro N, Van Snellenberg J, Tamayo Z, Wolf D, D’Souza D, Srihari V, Gueorguieva R, Patel P, Forselius-Bielen K, Lu J, Butler A, Fram G, Afriyie-Agyemang Y, Selloni A, Cadavid L, Gomez-Luna S, Gupta A, Radhakrishnan R, Rashid A, Aker R, Abrahim P, Nia A, Surti T, Kegeles L, Carlson M, Goldberg T, Gangwisch J, Benedict E, Govil P, Brazis S, Mayer M, de la Garrigue N, Fallon N, Baumvoll T, Abeykoon S, Perlman G, Bobchin K, Elliott M, Schmidt L, Rush S, Port A, Heffernan Z, Laney N, Kantor J, Hohing T, Gray D, Lieberman J. Dopamine D1R Receptor Stimulation as a Mechanistic Pro-cognitive Target for Schizophrenia. Schizophrenia Bulletin 2021, 48: 199-210. PMID: 34423843, PMCID: PMC8781338, DOI: 10.1093/schbul/sbab095.
- Krystal JH, Chow B, Vessicchio J, Henrie AM, Neylan TC, Krystal AD, Marx BP, Xu K, Jindal RD, Davis LL, Schnurr PP, Stein MB, Thase ME, Ventura B, Huang GD, Shih MC, Team T. Design of the national adaptive trial for PTSD-related insomnia (NAP study), VA cooperative study program (CSP) #2016. Contemporary Clinical Trials 2021, 109: 106540. PMID: 34416369, DOI: 10.1016/j.cct.2021.106540.
- Krystal JH, Kelmendi B, Petrakis IL. Psychotherapy-supported MDMA treatment for PTSD. Cell Reports Medicine 2021, 2: 100378. PMID: 34467253, PMCID: PMC8385322, DOI: 10.1016/j.xcrm.2021.100378.
- Haeny AM, Gueorguieva R, Jackson A, Morean ME, Krishnan-Sarin S, DeMartini KS, Pearlson GD, Anticevic A, Krystal JH, O’Malley S. Individual Differences in the Associations Between Risk Factors for Alcohol Use Disorder and Alcohol Use-Related Outcomes. Psychology Of Addictive Behaviors 2021, 35: 501-513. PMID: 34110841, PMCID: PMC9211405, DOI: 10.1037/adb0000733.
- Burt JB, Preller KH, Demirtas M, Ji JL, Krystal JH, Vollenweider FX, Anticevic A, Murray JD. Transcriptomics-informed large-scale cortical model captures topography of pharmacological neuroimaging effects of LSD. ELife 2021, 10: e69320. PMID: 34313217, PMCID: PMC8315798, DOI: 10.7554/elife.69320.
- Nestler EJ, Krystal JH. Ronald S. Duman (1954–2020): In Memoriam. Biological Psychiatry 2021, 90: 72-73. DOI: 10.1016/j.biopsych.2021.05.010.
- Beck K, Hindley G, Borgan F, Ginestet C, McCutcheon R, Brugger S, Driesen N, Ranganathan M, D'Souza D, Taylor M, Krystal J, Howes O. The effect of ketamine on psychopathology and implications for understanding schizophrenia and its therapeutic use: a meta-analysis. BJPsych Open 2021, 7: s237-s237. PMCID: PMC8771247, DOI: 10.1192/bjo.2021.634.
- Hill ML, Nichter B, Na PJ, Norman SB, Morland LA, Krystal JH, Pietrzak RH. Mental health impact of the COVID-19 pandemic in U.S. military veterans: a population-based, prospective cohort study. Psychological Medicine 2021, 53: 945-956. PMID: 34120667, PMCID: PMC8245339, DOI: 10.1017/s0033291721002361.
- Barron D, Heisig S, Agurto C, Norel R, Quagan B, Powers A, Baker J, Constable T, Cecchi G, Krystal J. Preliminary Evaluation of Phenotypic Features from Clinical Interactions. Journal Of Pain 2021, 22: 594. DOI: 10.1016/j.jpain.2021.03.068.
- McClurkin M, Krystal J, Kaye A, Damisah E. Human iEEG Characterization of Threat and Anxiety Oscillations Across Amygdala, Hippocampus, and Frontal Cortex. Biological Psychiatry 2021, 89: s255. DOI: 10.1016/j.biopsych.2021.02.638.
- Girgenti M, Skarica M, Zhang J, Wang J, Friedman M, Zhao H, Krystal J. Integrative Functional Genomic Analysis of Human PTSD Molecular Pathology and Risk. Biological Psychiatry 2021, 89: s12. DOI: 10.1016/j.biopsych.2021.02.050.
- DeMartini KS, Gueorguieva R, Pearlson G, Krishnan‐Sarin S, Anticevic A, Ji LJ, Krystal JH, O’Malley S. Mapping data‐driven individualized neurobehavioral phenotypes in heavy alcohol drinkers. Alcohol Clinical And Experimental Research 2021, 45: 841-853. PMID: 33605439, DOI: 10.1111/acer.14580.
- Pietrzak RH, Javier FG, Krystal JH, Southwick SM. Subthreshold post-traumatic stress disorder as a risk factor for post-traumatic stress disorder: results from a sample of USA veterans. The British Journal Of Psychiatry 2021, 219: 456-459. PMID: 35048836, DOI: 10.1192/bjp.2021.17.
- Wendt FR, Pathak GA, Levey DF, Nuñez YZ, Overstreet C, Tyrrell C, Adhikari K, De Angelis F, Tylee DS, Goswami A, Krystal JH, Abdallah CG, Stein MB, Kranzler HR, Gelernter J, Polimanti R. Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality. Neurobiology Of Stress 2021, 14: 100309. PMID: 33665242, PMCID: PMC7905234, DOI: 10.1016/j.ynstr.2021.100309.
- Lee EE, Torous J, De Choudhury M, Depp CA, Graham SA, Kim HC, Paulus MP, Krystal JH, Jeste DV. Artificial Intelligence for Mental Health Care: Clinical Applications, Barriers, Facilitators, and Artificial Wisdom. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2021, 6: 856-864. PMID: 33571718, PMCID: PMC8349367, DOI: 10.1016/j.bpsc.2021.02.001.
- Barron DS, Gao S, Dadashkarimi J, Greene AS, Spann MN, Noble S, Lake EMR, Krystal JH, Constable RT, Scheinost D. Transdiagnostic, Connectome-Based Prediction of Memory Constructs Across Psychiatric Disorders. Cerebral Cortex 2020, 31: 2523-2533. PMID: 33345271, PMCID: PMC8023861, DOI: 10.1093/cercor/bhaa371.
- Wendt FR, Pathak GA, Lencz T, Krystal JH, Gelernter J, Polimanti R. Multivariate genome-wide analysis of education, socioeconomic status and brain phenome. Nature Human Behaviour 2020, 5: 482-496. PMID: 33349686, PMCID: PMC8068566, DOI: 10.1038/s41562-020-00980-y.
- Girgenti MJ, Wang J, Ji D, Cruz DA, Stein M, Gelernter J, Young K, Huber B, Williamson D, Friedman M, Krystal J, Zhao H, Duman R. Transcriptomic organization of the human brain in post-traumatic stress disorder. Nature Neuroscience 2020, 24: 24-33. PMID: 33349712, DOI: 10.1038/s41593-020-00748-7.
- Hamilton HK, Roach BJ, Cavus I, Teyler TJ, Clapp WC, Ford JM, Tarakci E, Krystal JH, Mathalon DH. Impaired Potentiation of Theta Oscillations During a Visual Cortical Plasticity Paradigm in Individuals With Schizophrenia. Frontiers In Psychiatry 2020, 11: 590567. PMID: 33391054, PMCID: PMC7772351, DOI: 10.3389/fpsyt.2020.590567.
- Fogle BM, Tsai J, Mota N, Harpaz-Rotem I, Krystal JH, Southwick SM, Pietrzak RH. The National Health and Resilience in Veterans Study: A Narrative Review and Future Directions. Frontiers In Psychiatry 2020, 11: 538218. PMID: 33362593, PMCID: PMC7755975, DOI: 10.3389/fpsyt.2020.538218.
- Wang X, Xie H, Chen T, Cotton AS, Salminen LE, Logue MW, Clarke-Rubright EK, Wall J, Dennis EL, O’Leary B, Abdallah CG, Andrew E, Baugh LA, Bomyea J, Bruce SE, Bryant R, Choi K, Daniels JK, Davenport ND, Davidson RJ, DeBellis M, deRoon-Cassini T, Disner SG, Fani N, Fercho KA, Fitzgerald J, Forster GL, Frijling JL, Geuze E, Gomaa H, Gordon EM, Grupe D, Harpaz-Rotem I, Haswell CC, Herzog JI, Hofmann D, Hollifield M, Hosseini B, Hudson AR, Ipser J, Jahanshad N, Jovanovic T, Kaufman ML, King AP, Koch SBJ, Koerte IK, Korgaonkar MS, Krystal JH, Larson C, Lebois LAM, Levy I, Li G, Magnotta VA, Manthey A, May G, McLaughlin KA, Mueller SC, Nawijn L, Nelson SM, Neria Y, Nitschke JB, Olff M, Olson EA, Peverill M, Phan K, Rashid FM, Ressler K, Rosso IM, Sambrook K, Schmahl C, Shenton ME, Sierk A, Simons JS, Simons RM, Sponheim SR, Stein MB, Stein DJ, Stevens JS, Straube T, Suarez-Jimenez B, Tamburrino M, Thomopoulos SI, van der Wee NJA, van der Werff SJA, van Erp TGM, van Rooij SJH, van Zuiden M, Varkevisser T, Veltman DJ, Vermeiren RRJM, Walter H, Wang L, Zhu Y, Zhu X, Thompson PM, Morey RA, Liberzon I. Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis. Molecular Psychiatry 2020, 26: 4331-4343. PMID: 33288872, PMCID: PMC8180531, DOI: 10.1038/s41380-020-00967-1.
- Spiegelman D, Lovato LC, Khudyakov P, Wilkens TL, Adebamowo CA, Adebamowo SN, Appel LJ, Beulens JW, Coughlin JW, Dragsted LO, Edenberg HJ, Eriksen JN, Estruch R, Grobbee DE, Gulayin PE, Irazola V, Krystal JH, Lazo M, Murray MM, Rimm EB, Schrieks IC, Williamson JD, Mukamal KJ. The Moderate Alcohol and Cardiovascular Health Trial (MACH15): Design and methods for a randomized trial of moderate alcohol consumption and cardiometabolic risk. European Journal Of Preventive Cardiology 2020, 27: 1967-1982. PMID: 32250171, PMCID: PMC7541556, DOI: 10.1177/2047487320912376.
- Steine IM, Nielsen B, Porter PA, Krystal JH, Winje D, Grønli J, Milde AM, Bjorvatn B, Nordhus IH, Pallesen S. Predictors and correlates of lifetime and persistent non-suicidal self-injury and suicide attempts among adult survivors of childhood sexual abuse. European Journal Of Psychotraumatology 2020, 11: 1815282. PMID: 33312451, PMCID: PMC7717684, DOI: 10.1080/20008198.2020.1815282.
- Krystal JH. Publisher Correction: Responding to the hidden pandemic for healthcare workers: stress. Nature Medicine 2020, 26: 1951-1951. PMID: 33247290, DOI: 10.1038/s41591-020-01176-7.
- Krystal JH, Alvarado J, Ball SA, Fortunati FG, Hu M, Ivy ME, Kapo J, Olson KD, Rohrbaugh RM, Sinha R, Tebes JK, Vender RJ, Yonkers KA, Mayes LC. Mobilizing an institutional supportive response for healthcare workers and other staff in the context of COVID-19: The Yale experience. General Hospital Psychiatry 2020, 68: 12-18. PMID: 33254081, PMCID: PMC7680059, DOI: 10.1016/j.genhosppsych.2020.11.005.
- Moujaes F, Preller K, Vollenweider F, Schleifer C, Adkinson B, Kolobaric A, Fineberg S, Krystal J, Repovs G, Santamauro N, Morgan P, Savic A, Cho Y, D. M, Anticevic A. P.499 Ketamine's influence on global resting-state functional connectivity and individual variation in neuro-behavioural relationships. European Neuropsychopharmacology 2020, 40: s278-s279. DOI: 10.1016/j.euroneuro.2020.09.363.
- Krystal JH, Barch DM, Carter CS. Introducing a New Journal, Biological Psychiatry: Global Open Science. Biological Psychiatry 2020, 88: 890. PMID: 33213699, DOI: 10.1016/j.biopsych.2020.10.005.
- Characteristics of Ongoing Clinical Trials for Alcohol Use Disorder Registered on ClinicalTrials.govWallach JD, Krystal JH, Ross JS, O’Malley S. Characteristics of Ongoing Clinical Trials for Alcohol Use Disorder Registered on ClinicalTrials.gov. JAMA Psychiatry 2020, 77: 1081-1084. PMID: 32459295, PMCID: PMC7254444, DOI: 10.1001/jamapsychiatry.2020.1167.
- Tamman AJF, Wendt FR, Pathak GA, Krystal JH, Montalvo-Ortiz JL, Southwick SM, Sippel LM, Gelernter J, Polimanti R, Pietrzak RH. Attachment Style Moderates Polygenic Risk for Posttraumatic Stress in United States Military Veterans: Results From the National Health and Resilience in Veterans Study. Biological Psychiatry 2020, 89: 878-887. PMID: 33276944, DOI: 10.1016/j.biopsych.2020.09.018.
- Abdallah CG, Ahn KH, Averill LA, Nemati S, Averill CL, Fouda S, Ranganathan M, Morgan PT, D’Souza D, Mathalon DH, Krystal JH, Driesen NR. A robust and reproducible connectome fingerprint of ketamine is highly associated with the connectomic signature of antidepressants. Neuropsychopharmacology 2020, 46: 478-485. PMID: 32967000, PMCID: PMC7852889, DOI: 10.1038/s41386-020-00864-9.
- Stone LA, Girgenti MJ, Wang J, Ji D, Zhao H, Krystal JH, Duman R. Cortical Transcriptomic Alterations in Association With Appetitive Neuropeptides and Body Mass Index in Posttraumatic Stress Disorder. The International Journal Of Neuropsychopharmacology 2020, 24: 118-129. PMID: 32951025, PMCID: PMC8611677, DOI: 10.1093/ijnp/pyaa072.
- Hillmer AT, Angarita GA, Esterlis I, Anderson JM, Nabulsi N, Lim K, Ropchan J, Carson RE, Krystal JH, Malley S, Cosgrove KP. Longitudinal imaging of metabotropic glutamate 5 receptors during early and extended alcohol abstinence. Neuropsychopharmacology 2020, 46: 380-385. PMID: 32919411, PMCID: PMC7852514, DOI: 10.1038/s41386-020-00856-9.
- Li L, Li F, Fortunati F, Krystal JH. Association of a Prior Psychiatric Diagnosis With Mortality Among Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) Infection. JAMA Network Open 2020, 3: e2023282. PMID: 32997123, PMCID: PMC7527869, DOI: 10.1001/jamanetworkopen.2020.23282.
- Mason GF, Krystal JH. Mapping Lithium in the Brain: New 3-Dimensional Methodology Reveals Regional Distribution in Euthymic Patients With Bipolar Disorder. Biological Psychiatry 2020, 88: 367-368. PMID: 32792052, DOI: 10.1016/j.biopsych.2020.05.023.
- Krystal J. Robert T. Malison, M.D. (1959–2020). Neuropsychopharmacology 2020, 45: 2133-2134. PMCID: PMC7547671, DOI: 10.1038/s41386-020-00817-2.
- Kaye AP, Krystal JH. Predictive Processing in Mental Illness: Hierarchical Circuitry for Perception and Trauma. Journal Of Psychopathology And Clinical Science 2020, 129: 629-632. PMID: 32757606, DOI: 10.1037/abn0000628.
- Aghajanian GK, Mathé AA, Eriksson E, Krystal JH. Torgny Svensson, M.D., Ph.D. (1945–2020). Neuropsychopharmacology 2020, 45: 1960-1960. PMID: 32699343, PMCID: PMC7374074, DOI: 10.1038/s41386-020-0770-4.
- Moreno C, Wykes T, Galderisi S, Nordentoft M, Crossley N, Jones N, Cannon M, Correll CU, Byrne L, Carr S, Chen EYH, Gorwood P, Johnson S, Kärkkäinen H, Krystal JH, Lee J, Lieberman J, López-Jaramillo C, Männikkö M, Phillips MR, Uchida H, Vieta E, Vita A, Arango C. How mental health care should change as a consequence of the COVID-19 pandemic. The Lancet Psychiatry 2020, 7: 813-824. PMID: 32682460, PMCID: PMC7365642, DOI: 10.1016/s2215-0366(20)30307-2.
- Steine IM, Winje D, Krystal JH, Milde AM, Bjorvatn B, Nordhus IH, Grønli J, Pallesen S. Longitudinal Relationships between Perceived Social Support and Symptom Outcomes: Findings from a sample of Adult Survivors of Childhood Sexual Abuse. Child Abuse & Neglect 2020, 107: 104566. PMID: 32526550, DOI: 10.1016/j.chiabu.2020.104566.
- Kantrowitz JT, Grinband J, Goff DC, Lahti AC, Marder SR, Kegeles LS, Girgis RR, Sobeih T, Wall MM, Choo TH, Green MF, Yang YS, Lee J, Horga G, Krystal JH, Potter WZ, Javitt DC, Lieberman JA. Proof of mechanism and target engagement of glutamatergic drugs for the treatment of schizophrenia: RCTs of pomaglumetad and TS-134 on ketamine-induced psychotic symptoms and pharmacoBOLD in healthy volunteers. Neuropsychopharmacology 2020, 45: 1842-1850. PMID: 32403118, PMCID: PMC7608251, DOI: 10.1038/s41386-020-0706-z.
- Gur TL, Krystal JH. Biological Psychiatry Podcast Series: Support Resources for the COVID-19 Pandemic. Biological Psychiatry 2020, 88: 3. PMID: 32405077, PMCID: PMC7217797, DOI: 10.1016/j.biopsych.2020.05.008.
- Bhatt S, Hillmer AT, Girgenti MJ, Rusowicz A, Kapinos M, Nabulsi N, Huang Y, Matuskey D, Angarita GA, Esterlis I, Davis MT, Southwick SM, Friedman MJ, Duman R, Carson R, Krystal J, Pietrzak R, Cosgrove K. PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies. Nature Communications 2020, 11: 2360. PMID: 32398677, PMCID: PMC7217830, DOI: 10.1038/s41467-020-15930-5.
- Abdallah CG, Krystal JH. Ketamine and rapid acting antidepressants: Are we ready to cure, rather than treat depression? Behavioural Brain Research 2020, 390: 112628. PMID: 32407817, PMCID: PMC7316409, DOI: 10.1016/j.bbr.2020.112628.
- Barron D, Bzdok D, Krystal J, Constable R. What Can Machine Learning Do for Psychiatry? Biological Psychiatry 2020, 87: s462. DOI: 10.1016/j.biopsych.2020.02.1176.
- Barron D, Heisig S, Norel R, Agurto C, Quagan B, Powers A, Baker J, Constable R, Cecchi G, Krystal J. Preliminary Phenotypic Feature Capture During Clinical Interaction. Biological Psychiatry 2020, 87: s212-s213. DOI: 10.1016/j.biopsych.2020.02.552.
- Nemati S, Akiki T, Ju Y, Averill C, Fouda S, Dutta A, Mckie S, Krystal J, Deakin B, Averill L, Abdallah C. A Shift in Executive Connectivity Predates and Predicts Response to Treatment in Major Depressive Disorder. Biological Psychiatry 2020, 87: s107. DOI: 10.1016/j.biopsych.2020.02.294.
- Wendt F, Pathak G, Lencz T, Krystal J, Gelernter J, Polimanti R. Education and Socioeconomic Status Mask the Identification of Brain Cell Types in GWAS of Mental Health and Disease. Biological Psychiatry 2020, 87: s110. DOI: 10.1016/j.biopsych.2020.02.302.
- Beck K, Hindley G, Borgan F, Ginestet C, McCutcheon R, Brugger S, Driesen N, Ranganathan M, D’Souza D, Taylor M, Krystal JH, Howes OD. Association of Ketamine With Psychiatric Symptoms and Implications for Its Therapeutic Use and for Understanding Schizophrenia. JAMA Network Open 2020, 3: e204693. PMID: 32437573, PMCID: PMC7243091, DOI: 10.1001/jamanetworkopen.2020.4693.
- Stone L, Girgenti M, Krystal J, Duman R, Group T. Neural Transcriptomic Alterations Associated With Neuropeptide Y and Ghrelin in Posttraumatic Stress Disorder. Biological Psychiatry 2020, 87: s421-s422. DOI: 10.1016/j.biopsych.2020.02.1075.
- Girgenti M, Wang J, Ji D, Cruz D, Group T, Program M, Stein M, Gelernter J, Young K, Huber B, Williamson D, Friedman M, Krystal J, Zhao H, Duman R. Transcriptomic Organization of Human Posttraumatic Stress Disorder. Biological Psychiatry 2020, 87: s122. DOI: 10.1016/j.biopsych.2020.02.330.
- DeMartini KS, Pittman B, Krystal JH, O’Malley S, Krishnan‐Sarin S. Examining the Relationship Between Self‐Reported Drinking and In‐Laboratory Drinking and Craving: Is There Concordance? Alcohol Clinical And Experimental Research 2020, 44: 1151-1157. PMID: 32352581, PMCID: PMC10158572, DOI: 10.1111/acer.14329.
- Krystal JH. Responding to the hidden pandemic for healthcare workers: stress. Nature Medicine 2020, 26: 639-639. PMID: 32350461, DOI: 10.1038/s41591-020-0878-4.
- Koblan KS, Kent J, Hopkins SC, Krystal JH, Cheng H, Goldman R, Loebel A. A Non–D2-Receptor-Binding Drug for the Treatment of Schizophrenia. New England Journal Of Medicine 2020, 382: 1497-1506. PMID: 32294346, DOI: 10.1056/nejmoa1911772.
- Keizer BM, Roache JD, Jones JR, Kalpinski RJ, Porcerelli JH, Krystal JH. Continuous Ketamine Infusion for Pain as an Opportunity for Psychotherapy for PTSD: A Case Series of Ketamine-Enhanced Psychotherapy for PTSD and Pain (KEP-P2). Psychotherapy And Psychosomatics 2020, 89: 326-329. PMID: 32248200, DOI: 10.1159/000507095.
- Krystal JH, Charney DS, Duman RS. A New Rapid-Acting Antidepressant. Cell 2020, 181: 7. PMID: 32243798, DOI: 10.1016/j.cell.2020.02.033.
- Nestler E, Krystal J. Ronald S. Duman (1954–2020). Neuron 2020, 105: 769-770. DOI: 10.1016/j.neuron.2020.02.018.
- Hu Y, Ranganathan M, Shu C, Liang X, Ganesh S, Osafo-Addo A, Yan C, Zhang X, Aouizerat BE, Krystal JH, D’Souza D, Xu K. Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Scientific Reports 2020, 10: 3450. PMID: 32103029, PMCID: PMC7044203, DOI: 10.1038/s41598-020-59827-1.
- Abdallah CG, Averill LA, Gueorguieva R, Goktas S, Purohit P, Ranganathan M, Sherif M, Ahn KH, D’Souza D, Formica R, Southwick SM, Duman RS, Sanacora G, Krystal JH. Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin. Neuropsychopharmacology 2020, 45: 990-997. PMID: 32092760, PMCID: PMC7162891, DOI: 10.1038/s41386-020-0644-9.
- Krystal J, Nestler E, Picciotto M. Ronald S. Duman, Ph.D. (1954–2020). Neuropsychopharmacology 2020, 45: 1078-1078. PMCID: PMC7162938, DOI: 10.1038/s41386-020-0642-y.
- Garrison KA, DeMartini KS, Corlett PR, Worhunsky PD, Krystal JH, O'Malley SS. Drinking and responses to antidrinking messages among young adults: An fMRI study. Addiction Biology 2020, 26: e12882. PMID: 32068323, PMCID: PMC7431375, DOI: 10.1111/adb.12882.
- Hartwell EE, Feinn R, Morris PE, Gelernter J, Krystal J, Arias AJ, Hoffman M, Petrakis I, Gueorguieva R, Schacht JP, Oslin D, Anton RF, Kranzler HR. Systematic review and meta‐analysis of the moderating effect of rs1799971 in OPRM1, the mu‐opioid receptor gene, on response to naltrexone treatment of alcohol use disorder. Addiction 2020, 115: 1426-1437. PMID: 31961981, PMCID: PMC7340566, DOI: 10.1111/add.14975.
- Liang X, Justice AC, So-Armah K, Krystal JH, Sinha R, Xu K. DNA methylation signature on phosphatidylethanol, not on self-reported alcohol consumption, predicts hazardous alcohol consumption in two distinct populations. Molecular Psychiatry 2020, 26: 2238-2253. PMID: 32034291, PMCID: PMC8440221, DOI: 10.1038/s41380-020-0668-x.
- Krystal JH. Imaging the glutamate synapse. Nature Medicine 2020, 26: 165-167. PMID: 32015559, DOI: 10.1038/s41591-020-0760-4.
- Preller KH, Duerler P, Burt JB, Ji JL, Adkinson B, Stämpfli P, Seifritz E, Repovš G, Krystal JH, Murray JD, Anticevic A, Vollenweider FX. Psilocybin Induces Time-Dependent Changes in Global Functional Connectivity. Biological Psychiatry 2020, 88: 197-207. PMID: 32111343, DOI: 10.1016/j.biopsych.2019.12.027.
- McCutcheon RA, Krystal JH, Howes OD. Dopamine and glutamate in schizophrenia: biology, symptoms and treatment. World Psychiatry 2020, 19: 15-33. PMID: 31922684, PMCID: PMC6953551, DOI: 10.1002/wps.20693.
- Krystal JH. Preface: Remembering Ronald Stanton Duman, Ph.D. Advances In Pharmacology 2020, 89: xv-xvi. PMID: 32616216, DOI: 10.1016/s1054-3589(20)30048-x.
- Suzuki S, Mell MM, O'Malley SS, Krystal JH, Anticevic A, Kober H. Regulation of Craving and Negative Emotion in Alcohol Use Disorder. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 5: 239-250. PMID: 31892465, PMCID: PMC7010564, DOI: 10.1016/j.bpsc.2019.10.005.
- Nemati S, Akiki TJ, Roscoe J, Ju Y, Averill CL, Fouda S, Dutta A, McKie S, Krystal JH, Deakin JFW, Averill LA, Abdallah CG. A Unique Brain Connectome Fingerprint Predates and Predicts Response to Antidepressants. IScience 2019, 23: 100800. PMID: 31918047, PMCID: PMC6992944, DOI: 10.1016/j.isci.2019.100800.
- Dennis EL, Disner SG, Fani N, Salminen LE, Logue M, Clarke EK, Haswell CC, Averill CL, Baugh LA, Bomyea J, Bruce SE, Cha J, Choi K, Davenport ND, Densmore M, du Plessis S, Forster GL, Frijling JL, Gonenc A, Gruber S, Grupe DW, Guenette JP, Hayes J, Hofmann D, Ipser J, Jovanovic T, Kelly S, Kennis M, Kinzel P, Koch SBJ, Koerte I, Koopowitz S, Korgaonkar M, Krystal J, Lebois LAM, Li G, Magnotta VA, Manthey A, May GJ, Menefee DS, Nawijn L, Nelson SM, Neufeld RWJ, Nitschke JB, O’Doherty D, Peverill M, Ressler KJ, Roos A, Sheridan MA, Sierk A, Simmons A, Simons RM, Simons JS, Stevens J, Suarez-Jimenez B, Sullivan DR, Théberge J, Tran JK, van den Heuvel L, van der Werff SJA, van Rooij SJH, van Zuiden M, Velez C, Verfaellie M, Vermeiren RRJM, Wade BSC, Wager T, Walter H, Winternitz S, Wolff J, York G, Zhu Y, Zhu X, Abdallah CG, Bryant R, Daniels JK, Davidson RJ, Fercho KA, Franz C, Geuze E, Gordon EM, Kaufman ML, Kremen WS, Lagopoulos J, Lanius RA, Lyons MJ, McCauley SR, McGlinchey R, McLaughlin KA, Milberg W, Neria Y, Olff M, Seedat S, Shenton M, Sponheim SR, Stein DJ, Stein MB, Straube T, Tate DF, van der Wee NJA, Veltman DJ, Wang L, Wilde EA, Thompson PM, Kochunov P, Jahanshad N, Morey RA. Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium. Molecular Psychiatry 2019, 26: 4315-4330. PMID: 31857689, PMCID: PMC7302988, DOI: 10.1038/s41380-019-0631-x.
- Haeny AM, Gueorguieva R, Morean ME, Krishnan‐Sarin S, DeMartini KS, Pearlson GD, Anticevic A, Krystal JH, O'Malley SS. The Association of Impulsivity and Family History of Alcohol Use Disorder on Alcohol Use and Consequences. Alcohol Clinical And Experimental Research 2019, 44: 159-167. PMID: 31693193, PMCID: PMC6981005, DOI: 10.1111/acer.14230.
- Holmes SE, Gallezot JD, Davis MT, DellaGioia N, Matuskey D, Nabulsi N, Krystal JH, Javitch JA, DeLorenzo C, Carson RE, Esterlis I. Measuring the effects of ketamine on mGluR5 using [18F]FPEB and PET. Cerebrovascular And Brain Metabolism Reviews 2019, 40: 2254-2264. PMID: 31744389, PMCID: PMC7585925, DOI: 10.1177/0271678x19886316.
- Krishnan-Sarin S, O’Malley S, Franco N, Cavallo DA, Tetrault JM, Shi J, Gueorguieva R, Pittman B, Krystal JH. Influence of combined treatment with naltrexone and memantine on alcohol drinking behaviors: a phase II randomized crossover trial. Neuropsychopharmacology 2019, 45: 319-326. PMID: 31590179, PMCID: PMC6901445, DOI: 10.1038/s41386-019-0536-z.
- Mota NP, Cook JM, Smith NB, Tsai J, Harpaz-Rotem I, Krystal JH, Southwick SM, Pietrzak RH. Posttraumatic stress symptom courses in U.S. military veterans: A seven-year, nationally representative, prospective cohort study. Journal Of Psychiatric Research 2019, 119: 23-31. PMID: 31546045, DOI: 10.1016/j.jpsychires.2019.09.005.
- Xu K, Montalvo‐Ortiz J, Zhang X, Southwick SM, Krystal JH, Pietrzak RH, Gelernter J. Epigenome‐Wide DNA Methylation Association Analysis Identified Novel Loci in Peripheral Cells for Alcohol Consumption Among European American Male Veterans. Alcohol Clinical And Experimental Research 2019, 43: 2111-2121. PMID: 31386212, PMCID: PMC9377208, DOI: 10.1111/acer.14168.
- Chen MH, Cheng CM, Gueorguieva R, Lin WC, Li CT, Hong CJ, Tu PC, Bai YM, Tsai SJ, Krystal JH, Su TP. Maintenance of antidepressant and antisuicidal effects by D-cycloserine among patients with treatment-resistant depression who responded to low-dose ketamine infusion: a double-blind randomized placebo–control study. Neuropsychopharmacology 2019, 44: 2112-2118. PMID: 31421635, PMCID: PMC6898334, DOI: 10.1038/s41386-019-0480-y.
- Averill LA, Abdallah CG, Levey DF, Han S, Harpaz‐Rotem I, Kranzler HR, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study. Depression And Anxiety 2019, 36: 834-845. PMID: 31385647, DOI: 10.1002/da.22912.
- Quagliato LA, Cosci F, Shader RI, Silberman EK, Starcevic V, Balon R, Dubovsky SL, Salzman C, Krystal JH, Weintraub SJ, Freire RC, Nardi AE, Benzodiazepines I. Selective serotonin reuptake inhibitors and benzodiazepines in panic disorder: A meta-analysis of common side effects in acute treatment. Journal Of Psychopharmacology 2019, 33: 1340-1351. PMID: 31304840, DOI: 10.1177/0269881119859372.
- Kaffman A, White JD, Wei L, Johnson FK, Krystal JH. Enhancing the Utility of Preclinical Research in Neuropsychiatry Drug Development. Methods In Molecular Biology 2019, 2011: 3-22. PMID: 31273690, PMCID: PMC6895673, DOI: 10.1007/978-1-4939-9554-7_1.
- Wang W, Zhornitsky S, Le TM, Dhingra I, Zhang S, Krystal JH, Li CR. Cue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers. Journal Of Psychiatric Research 2019, 116: 74-82. PMID: 31202048, PMCID: PMC6606341, DOI: 10.1016/j.jpsychires.2019.06.005.
- Ji JL, Diehl C, Schleifer C, Tamminga CA, Keshavan MS, Sweeney JA, Clementz BA, Hill SK, Pearlson G, Yang G, Creatura G, Krystal JH, Repovs G, Murray J, Winkler A, Anticevic A. Schizophrenia Exhibits Bi-directional Brain-Wide Alterations in Cortico-Striato-Cerebellar Circuits. Cerebral Cortex 2019, 29: 4463-4487. PMID: 31157363, PMCID: PMC6917525, DOI: 10.1093/cercor/bhy306.
- Krystal JH, Yoon G, Petrakis IL. Rigorous Trial Design Is Essential to Understand the Role of Opioid Receptors in Ketamine’s Antidepressant Effect—Reply. JAMA Psychiatry 2019, 76: 658-659. PMID: 31042270, DOI: 10.1001/jamapsychiatry.2019.0763.
- Steine IM, Skogen JC, Krystal JH, Winje D, Milde AM, Grønli J, Nordhus IH, Bjorvatn B, Pallesen S. Insomnia symptom trajectories among adult survivors of childhood sexual abuse: A longitudinal study. Child Abuse & Neglect 2019, 93: 263-276. PMID: 31129428, DOI: 10.1016/j.chiabu.2019.05.009.
- Davis MT, Hillmer A, Holmes SE, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Angarita G, Carson RE, Krystal JH, Esterlis I. In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 11490-11495. PMID: 31085640, PMCID: PMC6561298, DOI: 10.1073/pnas.1818871116.
- Barron D, Gao S, Greene A, Constable R, Krystal J, Scheinost D. S179. Transdiagnostic Prediction of Memory and Executive Function From Whole-Brain Functional Connectivity. Biological Psychiatry 2019, 85: s366-s367. DOI: 10.1016/j.biopsych.2019.03.930.
- Cho Y, Schleifer C, Moujaes F, Starc M, Ji J, Santamauro N, Adkinson B, Kolobaric A, Flynn M, Krystal J, Murray J, Repovs G, Anticevic A. T193. Monetary Incentives Shape Behavioral and Neural Precision of Spatial Working Memory. Biological Psychiatry 2019, 85: s204-s205. DOI: 10.1016/j.biopsych.2019.03.516.
- Kaye A, Ressler K, Krystal J. S16. PTSD as a Threat Mood: Insights From a Reinforcement Learning Model. Biological Psychiatry 2019, 85: s302. DOI: 10.1016/j.biopsych.2019.03.767.
- Kolobaric A, Anticevic A, Hu X, Xiao Y, Hu J, Li F, Bi F, Cole M, Savic A, Yang G, Repovs G, Murray J, Wang X, Huang X, Lui S, Krystal J, Gong Q. T174. Examining the Neurobiological Progression of Early Course Schizophrenia. Biological Psychiatry 2019, 85: s196-s197. DOI: 10.1016/j.biopsych.2019.03.497.
- Hamilton H, Ford J, Roach B, Gunduz-Bruce H, Krystal J, Jaeger J, Reinhart R, Mathalon D. T161. Effects of Ketamine Administration on the P300 Event-Related Potential: Implications for Schizophrenia. Biological Psychiatry 2019, 85: s191. DOI: 10.1016/j.biopsych.2019.03.484.
- Moujaes F, Schleifer C, Ji L, Adkinson B, Kolobaric A, Flynn M, Fineberg S, Krystal J, Repovs G, Cho Y, Santamauro N, Morgan P, Savic A, Murray J, Anticevic A. F195. NMDAR Antagonism via Ketamine Differentially Modulates Thalamic Versus Hippocampal Brain-Wide Functional Connectivity. Biological Psychiatry 2019, 85: s289. DOI: 10.1016/j.biopsych.2019.03.732.
- Burt J, Preller K, Demirtas M, Ji J, Krystal J, Vollenweider F, Anticevic A, Murray J. S175. Large-Scale Model of Human Cortex Captures LSD-Induced Functional Alterations via HTR2A-Mediated Neural Gain Modulation. Biological Psychiatry 2019, 85: s365. DOI: 10.1016/j.biopsych.2019.03.926.
- Moujaes F, Preller K, Vollenweider F, Schleifer C, Ji J, Adkinson B, Kolobaric A, Flynn M, Fineberg S, Krystal J, Repovs G, Santamauro N, Morgan P, Savic A, Cho Y, Murray J, Anticevic A. S159. NMDA Receptor Antagonism Effects on Delayed Spatial Working Memory and Distraction in Comparison With Schizophrenia. Biological Psychiatry 2019, 85: s358. DOI: 10.1016/j.biopsych.2019.03.910.
- Abdallah CG, Roache JD, Averill LA, Young-McCaughan S, Martini B, Gueorguieva R, Amoroso T, Southwick SM, Guthmiller K, López-Roca AL, Lautenschlager K, Mintz J, Litz BT, Williamson DE, Keane TM, Peterson AL, Krystal JH, PTSD F. Repeated ketamine infusions for antidepressant-resistant PTSD: Methods of a multicenter, randomized, placebo-controlled clinical trial. Contemporary Clinical Trials 2019, 81: 11-18. PMID: 30999057, DOI: 10.1016/j.cct.2019.04.009.
- Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Lower synaptic density is associated with depression severity and network alterations. Nature Communications 2019, 10: 1529. PMID: 30948709, PMCID: PMC6449365, DOI: 10.1038/s41467-019-09562-7.
- Duman RS, Sanacora G, Krystal JH. Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments. Neuron 2019, 102: 75-90. PMID: 30946828, PMCID: PMC6450409, DOI: 10.1016/j.neuron.2019.03.013.
- Krystal JH, Abdallah CG, Sanacora G, Charney DS, Duman RS. Ketamine: A Paradigm Shift for Depression Research and Treatment. Neuron 2019, 101: 774-778. PMID: 30844397, PMCID: PMC6560624, DOI: 10.1016/j.neuron.2019.02.005.
- Yoon G, Petrakis IL, Krystal JH. Association of Combined Naltrexone and Ketamine With Depressive Symptoms in a Case series of Patients With Depression and Alcohol Use Disorder. JAMA Psychiatry 2019, 76: 337-338. PMID: 30624551, PMCID: PMC6439824, DOI: 10.1001/jamapsychiatry.2018.3990.
- Fleming LM, Javitt DC, Carter CS, Kantrowitz JT, Girgis RR, Kegeles LS, Ragland JD, Maddock RJ, Lesh TA, Tanase C, Robinson J, Potter WZ, Carlson M, Wall MM, Choo TH, Grinband J, Lieberman J, Krystal JH, Corlett PR. A multicenter study of ketamine effects on functional connectivity: Large scale network relationships, hubs and symptom mechanisms. NeuroImage Clinical 2019, 22: 101739. PMID: 30852397, PMCID: PMC6411494, DOI: 10.1016/j.nicl.2019.101739.
- Homan P, Levy I, Feltham E, Gordon C, Hu J, Li J, Pietrzak RH, Southwick S, Krystal JH, Harpaz-Rotem I, Schiller D. Author Correction: Neural computations of threat in the aftermath of combat trauma. Nature Neuroscience 2019, 22: 840-841. PMID: 30760852, DOI: 10.1038/s41593-019-0356-9.
- Tang Y, Zhou Q, Chang M, Chekroud A, Gueorguieva R, Jiang X, Zhou Y, He G, Rowland M, Wang D, Fu S, Yin Z, Leng H, Wei S, Xu K, Wang F, Krystal JH, Driesen NR. Altered functional connectivity and low-frequency signal fluctuations in early psychosis and genetic high risk. Schizophrenia Research 2019, 210: 172-179. PMID: 30685394, DOI: 10.1016/j.schres.2018.12.041.
- Homan P, Levy I, Feltham E, Gordon C, Hu J, Li J, Pietrzak RH, Southwick S, Krystal JH, Harpaz-Rotem I, Schiller D. Neural computations of threat in the aftermath of combat trauma. Nature Neuroscience 2019, 22: 470-476. PMID: 30664770, PMCID: PMC6829910, DOI: 10.1038/s41593-018-0315-x.
- Tamman AJF, Montalvo-Ortiz JL, Southwick SM, Krystal JH, Levy BR, Pietrzak RH. Accelerated DNA Methylation Aging in U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study. American Journal Of Geriatric Psychiatry 2019, 27: 528-532. PMID: 30792041, DOI: 10.1016/j.jagp.2019.01.001.
- Abdallah CG, Averill CL, Ramage AE, Averill LA, Goktas S, Nemati S, Krystal JH, Roache JD, Resick PA, Young-McCaughan S, Peterson AL, Fox P, Consortium T. Salience Network Disruption in U.S. Army Soldiers With Posttraumatic Stress Disorder. Chronic Stress 2019, 3: 2470547019850467. PMID: 31131337, PMCID: PMC6529942, DOI: 10.1177/2470547019850467.
- Abdallah CG, Averill CL, Ramage AE, Averill LA, Alkin E, Nemati S, Krystal JH, Roache JD, Resick P, Young-McCaughan S, Peterson AL, Fox P, Consortium T. Reduced Salience and Enhanced Central Executive Connectivity Following PTSD Treatment. Chronic Stress 2019, 3: 2470547019838971. PMID: 31008419, PMCID: PMC6469713, DOI: 10.1177/2470547019838971.
- Zhang X, Hu Y, Aouizerat BE, Peng G, Marconi VC, Corley MJ, Hulgan T, Bryant KJ, Zhao H, Krystal JH, Justice AC, Xu K. Machine learning selected smoking-associated DNA methylation signatures that predict HIV prognosis and mortality. Clinical Epigenetics 2018, 10: 155. PMID: 30545403, PMCID: PMC6293604, DOI: 10.1186/s13148-018-0591-z.
- Zhornitsky S, Zhang S, Ide JS, Chao HH, Wang W, Le TM, Leeman RF, Bi J, Krystal JH, Li CR. Alcohol Expectancy and Cerebral Responses to Cue-Elicited Craving in Adult Nondependent Drinkers. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 4: 493-504. PMID: 30711509, PMCID: PMC6500759, DOI: 10.1016/j.bpsc.2018.11.012.
- Su TP, Chen MH, Li CT, Lin WC, Hong CJ, Gueorguieva R, Tu PC, Bai YM, Cheng CM, Krystal JH. Correction: Dose-Related Effects of Adjunctive Ketamine in Taiwanese Patients with Treatment-Resistant Depression. Neuropsychopharmacology 2018, 44: 655-656. PMID: 30487654, PMCID: PMC6333826, DOI: 10.1038/s41386-018-0253-z.
- Preller KH, Burt JB, Ji JL, Schleifer CH, Adkinson BD, Stämpfli P, Seifritz E, Repovs G, Krystal JH, Murray JD, Vollenweider FX, Anticevic A. Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor. ELife 2018, 7: e35082. PMID: 30355445, PMCID: PMC6202055, DOI: 10.7554/elife.35082.
- Zhornitsky S, Ide J, Wang W, Chao H, Zhang S, Hu S, Krystal J, Li C. Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult Drinkers. Brain Connectivity 2018, 8: 487-502. PMID: 30198312, PMCID: PMC6207153, DOI: 10.1089/brain.2018.0633.
- Pitts BL, Whealin JM, Harpaz-Rotem I, Duman RS, Krystal JH, Southwick SM, Pietrzak RH. BDNF Val66Met polymorphism and posttraumatic stress symptoms in U.S. military veterans: Protective effect of physical exercise. Psychoneuroendocrinology 2018, 100: 198-202. PMID: 30388593, DOI: 10.1016/j.psyneuen.2018.10.011.
- Zhou H, Cheng Z, Bass N, Krystal JH, Farrer LA, Kranzler HR, Gelernter J. Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression. Translational Psychiatry 2018, 8: 208. PMID: 30287806, PMCID: PMC6172277, DOI: 10.1038/s41398-018-0258-8.
- Chekroud SR, Gueorguieva R, Zheutlin AB, Paulus M, Krumholz HM, Krystal JH, Chekroud AM. Physical activity and mental health – Author's reply. The Lancet Psychiatry 2018, 5: 874. PMID: 30245184, DOI: 10.1016/s2215-0366(18)30354-7.
- Abdallah CG, Averill LA, Akiki TJ, Raza M, Averill CL, Gomaa H, Adikey A, Krystal JH. The Neurobiology and Pharmacotherapy of Posttraumatic Stress Disorder. The Annual Review Of Pharmacology And Toxicology 2018, 59: 171-189. PMID: 30216745, PMCID: PMC6326888, DOI: 10.1146/annurev-pharmtox-010818-021701.
- Akiki TJ, Averill CL, Wrocklage KM, Scott JC, Averill LA, Schweinsburg B, Alexander-Bloch A, Martini B, Southwick SM, Krystal JH, Abdallah CG. Topology of brain functional connectivity networks in posttraumatic stress disorder. Data In Brief 2018, 20: 1658-1675. PMID: 30364328, PMCID: PMC6195053, DOI: 10.1016/j.dib.2018.08.198.
- Krystal JH. Celebrating 50 Years of Biological Psychiatry: To the Future, and Beyond. Biological Psychiatry 2018, 85: 2-4. PMID: 30527209, DOI: 10.1016/j.biopsych.2018.08.015.
- Chekroud SR, Gueorguieva R, Zheutlin AB, Paulus M, Krumholz HM, Krystal JH, Chekroud AM. Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015: a cross-sectional study. The Lancet Psychiatry 2018, 5: 739-746. PMID: 30099000, DOI: 10.1016/s2215-0366(18)30227-x.
- Nardi AE, Cosci F, Balon R, Weintraub SJ, Freire RC, Krystal JH, Roth T, Silberman EK, Sonino N, Fava GA, Starcevic V, Dubovsky SL, Salzman C, Rickels K, Greenblatt DJ, Shader RI, Chouinard G. The Prescription of Benzodiazepines for Panic Disorder. Journal Of Clinical Psychopharmacology 2018, 38: 283-285. PMID: 29912790, DOI: 10.1097/jcp.0000000000000908.
- Averill CL, Averill LA, Wrocklage KM, Scott JC, Akiki TJ, Schweinsburg B, Southwick SM, Krystal JH, Abdallah CG. Altered White Matter Diffusivity of the Cingulum Angular Bundle in Posttraumatic Stress Disorder. Complex Psychiatry 2018, 4: 75-82. PMID: 30397595, PMCID: PMC6206974, DOI: 10.1159/000490464.
- Chekroud AM, Foster D, Zheutlin AB, Gerhard DM, Roy B, Koutsouleris N, Chandra A, Esposti MD, Subramanyan G, Gueorguieva R, Paulus M, Krystal JH. Predicting Barriers to Treatment for Depression in a U.S. National Sample: A Cross-Sectional, Proof-of-Concept Study. Psychiatric Services 2018, 69: 927-934. PMID: 29962307, PMCID: PMC7232987, DOI: 10.1176/appi.ps.201800094.
- Abdallah CG, De Feyter HM, Averill LA, Jiang L, Averill CL, Chowdhury GMI, Purohit P, de Graaf RA, Esterlis I, Juchem C, Pittman BP, Krystal JH, Rothman DL, Sanacora G, Mason GF. The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects. Neuropsychopharmacology 2018, 43: 2154-2160. PMID: 29977074, PMCID: PMC6098048, DOI: 10.1038/s41386-018-0136-3.
- Zhang X, Zhang X, Hu Y, Justice A, Li B, Wang Z, Zhao H, Krystal J, Xu K. DNA methylation signatures analysis with Illumina Infinitum MethylationEPIC and Infinium Human Methylation 450K BeadChip. Protocol Exchange 2018 DOI: 10.1038/protex.2018.080.
- Abdallah CG, Sanacora G, Duman RS, Krystal JH. The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation? Pharmacology & Therapeutics 2018, 190: 148-158. PMID: 29803629, PMCID: PMC6165688, DOI: 10.1016/j.pharmthera.2018.05.010.
- Balon R, Chouinard G, Cosci F, Dubovsky SL, Fava GA, Freire RC, Greenblatt DJ, Krystal JH, Nardi AE, Rickels K, Roth T, Salzman C, Shader R, Silberman EK, Sonino N, Starcevic V, Weintraub SJ. International Task Force on Benzodiazepines. Psychotherapy And Psychosomatics 2018, 87: 193-194. PMID: 29788029, DOI: 10.1159/000489538.
- Wilkinson S, Ostroff R, Katz R, Krystal J. Erratum to: Ketamine: A Promising Rapid-Acting Antidepressant. 2018, e1-e1. DOI: 10.1007/978-981-10-6577-4_24.
- Ide JS, Zhornitsky S, Chao HH, Zhang S, Hu S, Wang W, Krystal JH, Li CR. Thalamic Cortical Error–Related Responses in Adult Social Drinkers: Sex Differences and Problem Alcohol Use. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 3: 868-877. PMID: 29859929, PMCID: PMC6177312, DOI: 10.1016/j.bpsc.2018.04.008.
- Akiki TJ, Averill CL, Wrocklage KM, Scott JC, Averill LA, Schweinsburg B, Alexander-Bloch A, Martini B, Southwick SM, Krystal JH, Abdallah CG. Default mode network abnormalities in posttraumatic stress disorder: A novel network-restricted topology approach. NeuroImage 2018, 176: 489-498. PMID: 29730491, PMCID: PMC5976548, DOI: 10.1016/j.neuroimage.2018.05.005.
- Cho Y, Schleifer C, Moujaes F, Starc M, Ji J, Santamauro N, Adkinson B, Lituchy M, Krystal J, Murray J, Repovs G, Anticevic A. S232. Effects of Incentive Presentation on Spatial Working Memory Performance. Biological Psychiatry 2018, 83: s438. DOI: 10.1016/j.biopsych.2018.02.1124.
- Girgenti M, Cruz D, Williamson D, Friedman M, Krystal J, Duman R. T103. Transcriptome Alterations for Posttraumatic Stress Disorder in Human Prefrontal Cortex. Biological Psychiatry 2018, 83: s168. DOI: 10.1016/j.biopsych.2018.02.439.
- Zhou H, Zhong Z, Bass N, Krystal J, Farrer L, Kranzler H, Gelernter J. F131. Genome-Wide Association Study Identifies Glutamate Ionotropic Receptor GRIA4 as a Risk Gene for Comorbid Nicotine Dependence and Major Depression. Biological Psychiatry 2018, 83: s288-s289. DOI: 10.1016/j.biopsych.2018.02.744.
- Kegeles LS, Horga G, Ghazzaoui R, Rosengard R, Ojeil N, Xu X, Slifstein M, Petrakis I, O’Malley S, Krystal JH, Abi-Dargham A. Enhanced Striatal Dopamine Release to Expectation of Alcohol: A Potential Risk Factor for Alcohol Use Disorder. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 3: 591-598. PMID: 29803635, PMCID: PMC6953614, DOI: 10.1016/j.bpsc.2018.03.018.
- Fuehrlein BS, Kachadourian LK, DeVylder EK, Trevisan LA, Potenza MN, Krystal JH, Southwick SM, Pietrzak RH. Trajectories of alcohol consumption in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. American Journal On Addictions 2018, 27: 383-390. PMID: 29667712, DOI: 10.1111/ajad.12731.
- Krystal J. 2. MICROCIRCUITS, MACROCIRCUITS, AND CORTICOL DYSFUNCTION IN SCHIZOPHRENIA: A COMPUTATIONAL AND TRANSLATIONAL NEUROSCIENCE PERSPECTIVE. Schizophrenia Bulletin 2018, 44: s1-s1. PMCID: PMC5887654, DOI: 10.1093/schbul/sby014.001.
- Morean ME, DeMartini KS, Foster D, Patock-Peckham J, Garrison KA, Corlett PR, Krystal JH, Krishan-Sarin S, O'Malley SS. The Self-Report Habit Index: Assessing habitual marijuana, alcohol, e-cigarette, and cigarette use. Drug And Alcohol Dependence 2018, 186: 207-214. PMID: 29609132, PMCID: PMC5912163, DOI: 10.1016/j.drugalcdep.2018.01.014.
- Cheng WJ, Chen CH, Chen CK, Huang MC, Pietrzak RH, Krystal JH, Xu K. Similar psychotic and cognitive profile between ketamine dependence with persistent psychosis and schizophrenia. Schizophrenia Research 2018, 199: 313-318. PMID: 29510925, DOI: 10.1016/j.schres.2018.02.049.
- Krystal JH, Abdallah CG, Pietrzak RH, Averill LA, Harpaz-Rotem I, Levy I, Kelmendi B, Southwick SM. Locus Coeruleus Hyperactivity in Posttraumatic Stress Disorder: Answers and Questions. Biological Psychiatry 2018, 83: 197-199. PMID: 29277190, DOI: 10.1016/j.biopsych.2017.09.027.
- D’Souza D, Carson RE, Driesen N, Johannesen J, Ranganathan M, Krystal JH, Ahn K, Bielen K, Carbuto M, Deaso E, D’Souza D, Ranganathan M, Naganawa M, Ranganathan M, D’Souza D, Nabulsi N, Zheng M, Lin S, Huang Y, Carson R, Driesen N, Ahn K, Morgan P, Suckow R, He G, McCarthy G, Krystal J, Johannesen J, Kenney J, Gelernter J, Gueorguieva R, Pittman B. Dose-Related Target Occupancy and Effects on Circuitry, Behavior, and Neuroplasticity of the Glycine Transporter-1 Inhibitor PF-03463275 in Healthy and Schizophrenia Subjects. Biological Psychiatry 2018, 84: 413-421. PMID: 29499855, PMCID: PMC6068006, DOI: 10.1016/j.biopsych.2017.12.019.
- Anticevic A, Krystal J, Murray J. Meeting Emerging Challenges and Opportunities in Psychiatry Through Computational Neuroscience. 2018, xiii-xxxi. DOI: 10.1016/b978-0-12-809825-7.02004-6.
- Chekroud AM, Loho H, Paulus M, Krystal JH. PTSD and the War of Words. Chronic Stress 2018, 2: 2470547018767387. PMID: 32440582, PMCID: PMC7219886, DOI: 10.1177/2470547018767387.
- Javitt DC, Carter CS, Krystal JH, Kantrowitz JT, Girgis RR, Kegeles LS, Ragland JD, Maddock RJ, Lesh TA, Tanase C, Corlett PR, Rothman DL, Mason G, Qiu M, Robinson J, Potter WZ, Carlson M, Wall MM, Choo TH, Grinband J, Lieberman JA. Utility of Imaging-Based Biomarkers for Glutamate-Targeted Drug Development in Psychotic Disorders: A Randomized Clinical Trial. JAMA Psychiatry 2018, 75: 11-19. PMID: 29167877, PMCID: PMC5833531, DOI: 10.1001/jamapsychiatry.2017.3572.
- Holmes SE, Scheinost D, DellaGioia N, Davis MT, Matuskey D, Pietrzak RH, Hampson M, Krystal JH, Esterlis I. Cerebellar and Prefrontal Cortical Alterations in PTSD: Structural and Functional Evidence. Chronic Stress 2018, 2: 2470547018786390. PMID: 30035247, PMCID: PMC6054445, DOI: 10.1177/2470547018786390.
- DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailtyZhang X, Hu Y, Justice AC, Li B, Wang Z, Zhao H, Krystal JH, Xu K. DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailty. Nature Communications 2017, 8: 2243. PMID: 29269866, PMCID: PMC5740109, DOI: 10.1038/s41467-017-02326-1.
- Byrne SP, Krystal JH, Rosenheck RA, Vessicchio J, Pietrzak RH. Correlates of Nonimprovement to Pharmacotherapy for Chronic, Antidepressant-Resistant, Military Service–Related Posttraumatic Stress Disorder. Journal Of Clinical Psychopharmacology 2017, 37: 717-721. PMID: 28945664, DOI: 10.1097/jcp.0000000000000777.
- Mota NP, Han S, Harpaz‐Rotem I, Maruff P, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH. Apolipoprotein E gene polymorphism, trauma burden, and posttraumatic stress symptoms in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Depression And Anxiety 2017, 35: 168-177. PMID: 29172227, PMCID: PMC5794529, DOI: 10.1002/da.22698.
- Zhang X, Zhang X, Hu Y, Justice A, Li B, Wang Z, Zhao H, Krystal J, Xu K. DNA methylation signatures analysis with Illumina Infinitum MethylationEPIC and Infinium Human Methylation 450K BeadChip. Protocol Exchange 2017 DOI: 10.1038/protex.2017.135.
- Yang B, Arias AJ, Feinn R, Krystal JH, Gelernter J, Petrakis IL. GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose‐Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers. Alcohol Clinical And Experimental Research 2017, 41: 2025-2032. PMID: 29131352, PMCID: PMC5764175, DOI: 10.1111/acer.13516.
- Andersen AM, Pietrzak RH, Kranzler HR, Ma L, Zhou H, Liu X, Kramer J, Kuperman S, Edenberg HJ, Nurnberger JI, Rice JP, Tischfield JA, Goate A, Foroud TM, Meyers JL, Porjesz B, Dick DM, Hesselbrock V, Boerwinkle E, Southwick SM, Krystal JH, Weissman MM, Levinson DF, Potash JB, Gelernter J, Han S. Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence. JAMA Psychiatry 2017, 74: 1153-1160. PMID: 28813562, PMCID: PMC5710224, DOI: 10.1001/jamapsychiatry.2017.2269.
- Watkins LE, Han S, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH. Association Between Functional Polymorphism in Neuropeptide Y Gene Promoter rs16147 and Resilience to Traumatic Stress in US Military Veterans. The Journal Of Clinical Psychiatry 2017, 78: e1058-e1059. PMID: 29099554, DOI: 10.4088/jcp.17l11646.
- Wilkinson S, Ostroff R, Katz R, Krystal J. Ketamine: A Promising Rapid-Acting Antidepressant. 2017, 223-239. DOI: 10.1007/978-981-10-6577-4_16.
- Krystal J. My Path to Psychiatry. Psychiatric News 2017, 52: 1-1. DOI: 10.1176/appi.pn.2017.10b1.
- Krystal JH, Davis LL, Neylan TC, Raskind M, Schnurr PP, Stein MB, Vessicchio J, Shiner B, Gleason TC, Huang GD. Reply to: It Is Time to Look for New Treatments for Posttraumatic Stress Disorder: Can Sympathetic System Modulation Be an Answer? Biological Psychiatry 2017, 84: e19-e20. PMID: 29132654, DOI: 10.1016/j.biopsych.2017.09.031.
- Petrakis IL, Ralevski E, Gueorguieva R, O'Malley SS, Arias A, Sevarino KA, Jane JS, O'Brien E, Krystal JH. Mecamylamine treatment for alcohol dependence: a randomized controlled trial. Addiction 2017, 113: 6-14. PMID: 28710873, PMCID: PMC5725262, DOI: 10.1111/add.13943.
- Tamman AJF, Sippel LM, Han S, Neria Y, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH. Attachment style moderates effects of FKBP5 polymorphisms and childhood abuse on post-traumatic stress symptoms: Results from the National Health and Resilience in Veterans Study. The World Journal Of Biological Psychiatry 2017, 20: 289-300. PMID: 28891785, DOI: 10.1080/15622975.2017.1376114.
- Krystal J. KL.01.01 Targeting glutamate in psychiatric disease. European Neuropsychopharmacology 2017, 27: s521. DOI: 10.1016/s0924-977x(17)30985-9.
- Abdallah CG, Averill CL, Salas R, Averill LA, Baldwin PR, Krystal JH, Mathew SJ, Mathalon DH. Prefrontal Connectivity and Glutamate Transmission: Relevance to Depression Pathophysiology and Ketamine Treatment. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2017, 2: 566-574. PMID: 29034354, PMCID: PMC5635826, DOI: 10.1016/j.bpsc.2017.04.006.
- Taylor JJ, Krystal JH, D'Souza DC, Gerrard JL, Corlett PR. Targeted neural network interventions for auditory hallucinations: Can TMS inform DBS? Schizophrenia Research 2017, 195: 455-462. PMID: 28969932, PMCID: PMC8141945, DOI: 10.1016/j.schres.2017.09.020.
- Scheinost D, Holmes SE, DellaGioia N, Schleifer C, Matuskey D, Abdallah CG, Hampson M, Krystal JH, Anticevic A, Esterlis I. Multimodal Investigation of Network Level Effects Using Intrinsic Functional Connectivity, Anatomical Covariance, and Structure-to-Function Correlations in Unmedicated Major Depressive Disorder. Neuropsychopharmacology 2017, 43: 1119-1127. PMID: 28944772, PMCID: PMC5854800, DOI: 10.1038/npp.2017.229.
- Logue MW, van Rooij SJH, Dennis EL, Davis SL, Hayes JP, Stevens JS, Densmore M, Haswell CC, Ipser J, Koch SBJ, Korgaonkar M, Lebois LAM, Peverill M, Baker JT, Boedhoe PSW, Frijling JL, Gruber SA, Harpaz-Rotem I, Jahanshad N, Koopowitz S, Levy I, Nawijn L, O’Connor L, Olff M, Salat DH, Sheridan MA, Spielberg JM, van Zuiden M, Winternitz SR, Wolff JD, Wolf EJ, Wang X, Wrocklage K, Abdallah CG, Bryant RA, Geuze E, Jovanovic T, Kaufman ML, King AP, Krystal JH, Lagopoulos J, Bennett M, Lanius R, Liberzon I, McGlinchey RE, McLaughlin KA, Milberg WP, Miller MW, Ressler KJ, Veltman DJ, Stein DJ, Thomaes K, Thompson PM, Morey RA. Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia. Biological Psychiatry 2017, 83: 244-253. PMID: 29217296, PMCID: PMC5951719, DOI: 10.1016/j.biopsych.2017.09.006.
- Esterlis I, Holmes SE, Sharma P, Krystal JH, DeLorenzo C. Metabotropic Glutamatergic Receptor 5 and Stress Disorders: Knowledge Gained From Receptor Imaging Studies. Biological Psychiatry 2017, 84: 95-105. PMID: 29100629, PMCID: PMC5858955, DOI: 10.1016/j.biopsych.2017.08.025.
- Krystal JH. Biological Psychiatry: A New Approach to Reviews. Biological Psychiatry 2017, 82: 620. PMID: 28918940, DOI: 10.1016/j.biopsych.2017.07.025.
- Kelmendi B, Adams TG, Southwick S, Abdallah CG, Krystal JH. Posttraumatic Stress Disorder: An Integrated Overview of the Neurobiological Rationale for Pharmacology. Clinical Psychology Science And Practice 2017, 24: 281-297. PMID: 31404451, PMCID: PMC6688474, DOI: 10.1111/cpsp.12202.
- Krystal JH, Abdallah CG, Averill LA, Kelmendi B, Harpaz-Rotem I, Sanacora G, Southwick SM, Duman RS. Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic. Current Psychiatry Reports 2017, 19: 74. PMID: 28844076, PMCID: PMC5904792, DOI: 10.1007/s11920-017-0829-z.
- Holmes SE, Girgenti MJ, Davis MT, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Duman RS, Carson RE, Krystal JH, Esterlis I, Friedman M, Kowall N, Brady C, McKee A, Stein T, Huber B, Kaloupek D, Alvarez V, Benedek D, Ursano R, Williamson D, Cruz D, Young K, Duman R, Krystal J, Mash D, Hardegree M, Serlin G. Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 8390-8395. PMID: 28716937, PMCID: PMC5547601, DOI: 10.1073/pnas.1701749114.
- Sippel LM, Han S, Watkins LE, Harpaz-Rotem I, Southwick SM, Krystal JH, Olff M, Sherva R, Farrer LA, Kranzler HR, Gelernter J, Pietrzak RH. Oxytocin receptor gene polymorphisms, attachment, and PTSD: Results from the National Health and Resilience in Veterans Study. Journal Of Psychiatric Research 2017, 94: 139-147. PMID: 28715704, PMCID: PMC5605420, DOI: 10.1016/j.jpsychires.2017.07.008.
- Wisco BE, Marx BP, Miller MW, Wolf EJ, Krystal JH, Southwick SM, Pietrzak RH. A comparison of ICD-11 and DSM criteria for posttraumatic stress disorder in two national samples of U.S. military veterans. Journal Of Affective Disorders 2017, 223: 17-19. PMID: 28715723, DOI: 10.1016/j.jad.2017.07.006.
- Stefanovics EA, Rosenheck RA, Jones KM, Huang G, Krystal JH. Minimal Clinically Important Differences (MCID) in Assessing Outcomes of Post-Traumatic Stress Disorder. Psychiatric Quarterly 2017, 89: 141-155. PMID: 28634644, DOI: 10.1007/s11126-017-9522-y.
- Su TP, Chen MH, Li CT, Lin WC, Hong CJ, Gueorguieva R, Tu PC, Bai YM, Cheng CM, Krystal JH. Dose-Related Effects of Adjunctive Ketamine in Taiwanese Patients with Treatment-Resistant Depression. Neuropsychopharmacology 2017, 42: 2482-2492. PMID: 28492279, PMCID: PMC5686503, DOI: 10.1038/npp.2017.94.
- Cho Y, Schleifer C, Starc M, Ji J, Santamauro N, Adkinson B, Lituchy M, Krystal J, Murray J, Repovs G, Anticevic A. 961 Incentives to Perform: The Effects of Reward on Working Memory. Biological Psychiatry 2017, 81: s389. DOI: 10.1016/j.biopsych.2017.02.687.
- Cortes-Briones J, Skosnik P, D’Souza D, Abdallah C, Petrakis I, Krystal J. 67 Ketamine-induced Changes in Neural Noise and their Relationship to Psychosis-like Symptoms. Biological Psychiatry 2017, 81: s28. DOI: 10.1016/j.biopsych.2017.02.078.
- Morey R, Logue M, van Rooij S, Dennis E, Davis S, Hayes J, Stevens J, Densmore M, Koch S, Korgaonkar M, LeBois L, Peverill M, Jahanshad N, Lagopoulos J, Gueze E, Jovanovic T, Abdallah C, Bennett M, King A, Krystal J, Bryant R, Miller M, Veltman D, McLaughlin K, Lanius R, Stein D, Thomaes K, Liberzon I, Ressler K, Thompson P. 87 Volume of Sub-Cortical Structures in Posttraumatic Stress Disorder from Multi-Site Investigation by ENIGMA and PGC Consortia. Biological Psychiatry 2017, 81: s36-s37. DOI: 10.1016/j.biopsych.2017.02.099.
- Ferri J, Ford J, Roach B, Perry-O׳Leary D, Jaeger J, Gunduz-Bruce H, Krystal J, Mathalon D. 539 Ketamine, an NMDA-Receptor Antagonist, Mimics the Patterns of Intrinsically but Not Extrinsically Driven Gamma Oscillations. Biological Psychiatry 2017, 81: s218-s219. DOI: 10.1016/j.biopsych.2017.02.1147.
- Akiki T, Averill C, Wrocklage K, Scott J, Alexander-Bloch A, Southwick S, Krystal J, Abdallah C. 581 The Default Mode Network in Posttraumatic Stress Disorder (PTSD): A Data-Driven Multimodal Approach. Biological Psychiatry 2017, 81: s235. DOI: 10.1016/j.biopsych.2017.02.451.
- Hamilton H, Kort N, Ford J, Roach B, Gunduz-Bruce H, Krystal J, Jaeger J, Reinhart R, Mathalon D. 540 Effects of N-methyl-D-aspartate Glutamate Receptor Disruption and Nicotinic Acetylcholine Enhancement on Mismatch Negativity. Biological Psychiatry 2017, 81: s219. DOI: 10.1016/j.biopsych.2017.02.1148.
- Anticevic A, Schleifer C, Srihari V, Krystal J, Murray J, Repovs G, Xu G, Ji L, Cho Y, Santamauro N, Foss-Feig J, Yang G, Morgan P, Savic A. 423 NMDAR Antagonism via Ketamine Differentially Modulates Thalamic versus Hippocampal Functional Connectivity. Biological Psychiatry 2017, 81: s172-s173. DOI: 10.1016/j.biopsych.2017.02.907.
- Esterlis I, Pietrzak R, DellaGioia N, Matuskey D, Huang H, Krystal J, Duman R, Carson R, Finnema S. 389 In Vivo Evidence of Lower Synaptic Density in Depression and Associated Mood and Cognitive Deficits: A [11C]UCB-J PET Imaging Study. Biological Psychiatry 2017, 81: s159. DOI: 10.1016/j.biopsych.2017.02.406.
- Davis M, Holmes S, Pietrzak R, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Carson R, Krystal J, Esterlis I. 18 In Vivo Quantification of mGluR5 Availability in Posttraumatic Stress Disorder. Biological Psychiatry 2017, 81: s8. DOI: 10.1016/j.biopsych.2017.02.029.
- Preller K, Schleifer C, Stämpfli P, Krystal J, Vollenweider F, Anticevic A. 951 Changes in Resting-State Global Brain Connectivity in LSD-Induced Altered States of Consciousness are Attributable to the 5-HT2A Receptor. Biological Psychiatry 2017, 81: s385. DOI: 10.1016/j.biopsych.2017.02.677.
- Abdallah CG, Southwick SM, Krystal JH. Neurobiology of posttraumatic stress disorder (PTSD): A path from novel pathophysiology to innovative therapeutics. Neuroscience Letters 2017, 649: 130-132. PMID: 28478864, DOI: 10.1016/j.neulet.2017.04.046.
- Esterlis I, DellaGioia N, Pietrzak RH, Matuskey D, Nabulsi N, Abdallah CG, Yang J, Pittenger C, Sanacora G, Krystal JH, Parsey RV, Carson RE, DeLorenzo C. Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression. Molecular Psychiatry 2017, 23: 824-832. PMID: 28397841, PMCID: PMC5636649, DOI: 10.1038/mp.2017.58.
- Chekroud AM, Gueorguieva R, Krumholz HM, Trivedi MH, Krystal JH, McCarthy G. Reevaluating the Efficacy and Predictability of Antidepressant Treatments: A Symptom Clustering Approach. JAMA Psychiatry 2017, 74: 370-378. PMID: 28241180, PMCID: PMC5863470, DOI: 10.1001/jamapsychiatry.2017.0025.
- Chekroud AM, Loho H, Krystal JH. Mental illness and mental health. The Lancet Psychiatry 2017, 4: 276-277. PMID: 28347431, DOI: 10.1016/s2215-0366(17)30088-3.
- Ide JS, Zhornitsky S, Hu S, Zhang S, Krystal JH, Li CR. Sex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study. NeuroImage Clinical 2017, 14: 750-759. PMID: 28413777, PMCID: PMC5385596, DOI: 10.1016/j.nicl.2017.03.015.
- Wisco BE, Marx BP, May CL, Martini B, Krystal JH, Southwick SM, Pietrzak RH. Moral injury in U.S. combat veterans: Results from the national health and resilience in veterans study. Depression And Anxiety 2017, 34: 340-347. PMID: 28370818, DOI: 10.1002/da.22614.
- Posttraumatic symptom profiles among adult survivors of childhood sexual abuse: A longitudinal studySteine IM, Winje D, Skogen JC, Krystal JH, Milde AM, Bjorvatn B, Nordhus IH, Grønli J, Pallesen S. Posttraumatic symptom profiles among adult survivors of childhood sexual abuse: A longitudinal study. Child Abuse & Neglect 2017, 67: 280-293. PMID: 28327414, DOI: 10.1016/j.chiabu.2017.03.002.
- Foss-Feig JH, Adkinson BD, Ji JL, Yang G, Srihari VH, McPartland JC, Krystal JH, Murray JD, Anticevic A. Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders. Biological Psychiatry 2017, 81: 848-861. PMID: 28434615, PMCID: PMC5436134, DOI: 10.1016/j.biopsych.2017.03.005.
- Krystal JH, Davis LL, Neylan TC, Raskind M, Schnurr PP, Stein MB, Vessicchio J, Shiner B, Gleason TD, Huang GD. It Is Time to Address the Crisis in the Pharmacotherapy of Posttraumatic Stress Disorder: A Consensus Statement of the PTSD Psychopharmacology Working Group. Biological Psychiatry 2017, 82: e51-e59. PMID: 28454621, DOI: 10.1016/j.biopsych.2017.03.007.
- Krystal JH, Murray JD, Chekroud AM, Corlett PR, Yang G, Wang XJ, Anticevic A. Computational Psychiatry and the Challenge of Schizophrenia. Schizophrenia Bulletin 2017, 43: 473-475. PMID: 28338845, PMCID: PMC5464204, DOI: 10.1093/schbul/sbx025.
- Wrocklage KM, Averill LA, Scott J, Averill CL, Schweinsburg B, Trejo M, Roy A, Weisser V, Kelly C, Martini B, Harpaz-Rotem I, Southwick SM, Krystal JH, Abdallah CG. Cortical thickness reduction in combat exposed U.S. veterans with and without PTSD. European Neuropsychopharmacology 2017, 27: 515-525. PMID: 28279623, PMCID: PMC5429865, DOI: 10.1016/j.euroneuro.2017.02.010.
- Abdallah CG, Wrocklage KM, Averill CL, Akiki T, Schweinsburg B, Roy A, Martini B, Southwick SM, Krystal JH, Scott JC. Anterior hippocampal dysconnectivity in posttraumatic stress disorder: a dimensional and multimodal approach. Translational Psychiatry 2017, 7: e1045-e1045. PMID: 28244983, PMCID: PMC5545643, DOI: 10.1038/tp.2017.12.
- Abdallah CG, Averill LA, Krystal JH. A New Journal: Addressing the Behavioral and Biological Effects of Chronic Stress. Chronic Stress 2017, 1: 2470547016683296. PMID: 32440577, PMCID: PMC7219917, DOI: 10.1177/2470547016683296.
- Goldenberg MN, Krystal JH. Undergraduate Neuroscience Majors: A Missed Opportunity for Psychiatry Workforce Development. Academic Psychiatry 2017, 41: 239-242. PMID: 28188505, DOI: 10.1007/s40596-017-0670-z.
- Gueorguieva R, Chekroud AM, Krystal JH. Trajectories of relapse in randomised, placebo-controlled trials of treatment discontinuation in major depressive disorder: an individual patient-level data meta-analysis. The Lancet Psychiatry 2017, 4: 230-237. PMID: 28189575, PMCID: PMC5340978, DOI: 10.1016/s2215-0366(17)30038-x.
- Averill LA, Abdallah CG, Pietrzak RH, Averill CL, Southwick SM, Krystal JH, Harpaz-Rotem I. Combat Exposure Severity Is Associated With Reduced Cortical Thickness in Combat Veterans: A Preliminary Report. Chronic Stress 2017, 1: 2470547017724714. PMID: 28845475, PMCID: PMC5568834, DOI: 10.1177/2470547017724714.
- Averill CL, Satodiya RM, Scott JC, Wrocklage KM, Schweinsburg B, Averill LA, Akiki TJ, Amoroso T, Southwick SM, Krystal JH, Abdallah CG. Posttraumatic Stress Disorder and Depression Symptom Severities Are Differentially Associated With Hippocampal Subfield Volume Loss in Combat Veterans. Chronic Stress 2017, 1: 2470547017744538. PMID: 29520395, PMCID: PMC5839647, DOI: 10.1177/2470547017744538.
- Akiki TJ, Averill CL, Wrocklage KM, Schweinsburg B, Scott JC, Martini B, Averill LA, Southwick SM, Krystal JH, Abdallah CG. The Association of PTSD Symptom Severity With Localized Hippocampus and Amygdala Abnormalities. Chronic Stress 2017, 1: 2470547017724069. PMID: 28825050, PMCID: PMC5562232, DOI: 10.1177/2470547017724069.
- Chang F, Xu K, Huang MC, Krystal JH. Alcohol Triggers Reemergence of Ketamine-Like Experience in a Ketamine Ex-User. Journal Of Clinical Psychopharmacology 2017, 37: 110-112. PMID: 28027112, PMCID: PMC5193231, DOI: 10.1097/jcp.0000000000000635.
- Krystal JH, Petrakis IL, O’Malley S, Krishnan-Sarin S, Pearlson G, Yoon G. NMDA Glutamate Receptor Antagonism and the Heritable Risk for Alcoholism: New Insights from a Study of Nitrous Oxide. The International Journal Of Neuropsychopharmacology 2017, 20: 351-353. PMID: 28158462, PMCID: PMC5409033, DOI: 10.1093/ijnp/pyw118.
- Steine IM, Winje D, Krystal JH, Bjorvatn B, Milde AM, Grønli J, Nordhus IH, Pallesen S. Cumulative childhood maltreatment and its dose-response relation with adult symptomatology: Findings in a sample of adult survivors of sexual abuse. Child Abuse & Neglect 2017, 65: 99-111. PMID: 28131947, DOI: 10.1016/j.chiabu.2017.01.008.
- Krystal JH, Anticevic A, Yang GJ, Dragoi G, Driesen NR, Wang XJ, Murray JD. Impaired Tuning of Neural Ensembles and the Pathophysiology of Schizophrenia: A Translational and Computational Neuroscience Perspective. Biological Psychiatry 2017, 81: 874-885. PMID: 28434616, PMCID: PMC5407407, DOI: 10.1016/j.biopsych.2017.01.004.
- Steine IM, Zayats T, Stansberg C, Pallesen S, Mrdalj J, Håvik B, Soulé J, Haavik J, Milde AM, Skrede S, Murison R, Krystal J, Grønli J. Implication of NOTCH1 gene in susceptibility to anxiety and depression among sexual abuse victims. Translational Psychiatry 2016, 6: e977-e977. PMID: 27959334, PMCID: PMC5290341, DOI: 10.1038/tp.2016.248.
- Krystal J, Anticevic A, Murray J, Glahn D, Driesen N, Yang G, Wang X. Clinical Heterogeneity Arising from Categorical and Dimensional Features of the Neurobiology of Psychiatric Diagnoses: Insights from Neuroimaging and Computational Neuroscience. 2016, 293-316. DOI: 10.7551/mitpress/10936.003.0023.
- Averill LA, Purohit P, Averill CL, Boesl MA, Krystal JH, Abdallah CG. Glutamate dysregulation and glutamatergic therapeutics for PTSD: Evidence from human studies. Neuroscience Letters 2016, 649: 147-155. PMID: 27916636, PMCID: PMC5482215, DOI: 10.1016/j.neulet.2016.11.064.
- Kelmendi B, Corlett P, Ranganathan M, D’Souza C, Krystal JH. The role of psychedelics in palliative care reconsidered: A case for psilocybin. Journal Of Psychopharmacology 2016, 30: 1212-1214. PMID: 27909173, DOI: 10.1177/0269881116675781.
- Krystal J, Anticevic A, Murray J, Glahn D, Driesen N, Yang G, Wang X. Clinical Heterogeneity Arising from Categorical and Dimensional Features of the Neurobiology of Psychiatric Diagnoses. 2016 DOI: 10.7551/mitpress/9780262035422.003.0016.
- Yehuda R, Spiegel D, Southwick S, Davis LL, Neylan TC, Krystal JH. What I have changed my mind about and why. European Journal Of Psychotraumatology 2016, 7: 33768. PMID: 27837585, PMCID: PMC5106864, DOI: 10.3402/ejpt.v7.33768.
- Kelmendi B, Adams TG, Yarnell S, Southwick S, Abdallah CG, Krystal JH. PTSD: from neurobiology to pharmacological treatments. European Journal Of Psychotraumatology 2016, 7: 31858. PMID: 27837583, PMCID: PMC5106865, DOI: 10.3402/ejpt.v7.31858.
- Khlestova E, Johnson JW, Krystal JH, Lisman J. The Role of GluN2C-Containing NMDA Receptors in Ketamine's Psychotogenic Action and in Schizophrenia Models. Journal Of Neuroscience 2016, 36: 11151-11157. PMID: 27807157, PMCID: PMC5148234, DOI: 10.1523/jneurosci.1203-16.2016.
- Isaacs K, Mota NP, Tsai J, Harpaz-Rotem I, Cook JM, Kirwin PD, Krystal JH, Southwick SM, Pietrzak RH. Psychological resilience in U.S. military veterans: A 2-year, nationally representative prospective cohort study. Journal Of Psychiatric Research 2016, 84: 301-309. PMID: 27814502, DOI: 10.1016/j.jpsychires.2016.10.017.
- Starc M, Murray JD, Santamauro N, Savic A, Diehl C, Cho YT, Srihari V, Morgan PT, Krystal JH, Wang XJ, Repovs G, Anticevic A. Schizophrenia is associated with a pattern of spatial working memory deficits consistent with cortical disinhibition. Schizophrenia Research 2016, 181: 107-116. PMID: 27745755, PMCID: PMC5901719, DOI: 10.1016/j.schres.2016.10.011.
- Yang GJ, Murray JD, Glasser M, Pearlson GD, Krystal JH, Schleifer C, Repovs G, Anticevic A. Altered Global Signal Topography in Schizophrenia. Cerebral Cortex 2016, 27: 5156-5169. PMID: 27702810, PMCID: PMC6075538, DOI: 10.1093/cercor/bhw297.
- Steiner JL, Anez-Nava L, Baranoski M, Cole R, Davidson L, Delphin-Rittmon M, Dike C, DiLeo PJ, Duman RS, Kirk T, Krystal J, Malison RT, Rohrbaugh RM, Sernyak MJ, Srihari V, Styron T, Tebes JK, Woods S, Zonana H, Jacobs SC. The Connecticut Mental Health Center: Celebrating 50 Years of a Successful Partnership Between the State and Yale University. Psychiatric Services 2016, 67: 1286-1289. PMID: 27691379, DOI: 10.1176/appi.ps.201600373.
- Mukamal KJ, Clowry CM, Murray MM, Hendriks HF, Rimm EB, Sink KM, Adebamowo CA, Dragsted LO, Lapinski PS, Lazo M, Krystal JH. Moderate Alcohol Consumption and Chronic Disease: The Case for a Long‐Term Trial. Alcohol Clinical And Experimental Research 2016, 40: 2283-2291. PMID: 27688006, PMCID: PMC5073014, DOI: 10.1111/acer.13231.
- Zhang X, Justice AC, Hu Y, Wang Z, Zhao H, Wang G, Johnson EO, Emu B, Sutton RE, Krystal JH, Xu K. Epigenome-wide differential DNA methylation between HIV-infected and uninfected individuals. Epigenetics 2016, 11: 750-760. PMID: 27672717, PMCID: PMC5094631, DOI: 10.1080/15592294.2016.1221569.
- Knickman J, Krishnan K, Pincus H, Blanco C, Blazer D, Coye M, Krystal J, Rauch S, Simon G, Vitiello B. Improving Access to Effective Care for People Who Have Mental Health and Substance Use Disorders: A Vital Direction for Health and Health Care. NAM Perspectives 2016, 6 DOI: 10.31478/201609v.
- Pietrzak RH, Zhu Y, Slade MD, Qi Q, Krystal JH, Southwick SM, Levy BR. Association Between Negative Age Stereotypes and Accelerated Cellular Aging: Evidence from Two Cohorts of Older Adults. Journal Of The American Geriatrics Society 2016, 64: e228-e230. PMID: 27641354, PMCID: PMC5118148, DOI: 10.1111/jgs.14452.
- Watkins LE, Harpaz-Rotem I, Sippel LM, Krystal JH, Southwick SM, Pietrzak RH. Hostility and telomere shortening among U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Psychoneuroendocrinology 2016, 74: 251-257. PMID: 27689898, DOI: 10.1016/j.psyneuen.2016.09.006.
- Wisco BE, Marx BP, Miller MW, Wolf EJ, Mota NP, Krystal JH, Southwick SM, Pietrzak RH. Probable Posttraumatic Stress Disorder in the US Veteran Population According to DSM-5: Results From the National Health and Resilience in Veterans Study. The Journal Of Clinical Psychiatry 2016, 77: 1503-1510. PMID: 27631148, DOI: 10.4088/jcp.15m10188.
- Heinz A, Voss M, Lawrie SM, Mishara A, Bauer M, Gallinat J, Juckel G, Lang U, Rapp M, Falkai P, Strik W, Krystal J, Abi-Dargham A, Galderisi S. Shall we really say goodbye to first rank symptoms? European Psychiatry 2016, 37: 8-13. PMID: 27429167, DOI: 10.1016/j.eurpsy.2016.04.010.
- Hodgson K, Almasy L, Knowles EE, Kent JW, Curran JE, Dyer TD, Göring HH, Olvera RL, Fox PT, Pearlson GD, Krystal JH, Duggirala R, Blangero J, Glahn DC. Genome-wide significant loci for addiction and anxiety. European Psychiatry 2016, 36: 47-54. PMID: 27318301, PMCID: PMC5483998, DOI: 10.1016/j.eurpsy.2016.03.004.
- Krystal JH, Bugno R. Biological Psychiatry: We’re Just Getting Started! Biological Psychiatry 2016, 80: 500-501. PMID: 27601337, DOI: 10.1016/j.biopsych.2016.06.024.
- Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AF, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA, Carter CS, Cook EH, Daskalakis ZJ, DiLeone RJ, Duman RS, Grace AA, Hariri AR, Harrison PJ, Hiroi N, Kenny PJ, Kleinman JE, Krystal AD, Lewis DA, Lipska BK, Marder SR, Mason GF, Mathalon DH, McClung CA, McDougle CJ, McIntosh AM, McMahon FJ, Mirnics K, Monteggia LM, Narendran R, Nestler EJ, Neumeister A, O’Donovan M, Öngür D, Pariante CM, Paulus MP, Pearlson G, Phillips ML, Pine DS, Pizzagalli DA, Pletnikov MV, Ragland JD, Rapoport JL, Ressler KJ, Russo SJ, Sanacora G, Sawa A, Schatzberg AF, Shaham Y, Shamay-Tsoory SG, Sklar P, State MW, Stein MB, Strakowski SM, Taylor SF, Turecki G, Turetsky BI, Weissman MM, Zachariou V, Zarate CA, Zubieta JK. Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research. Biological Psychiatry 2016, 80: 84-86. PMID: 27346079, PMCID: PMC6150945, DOI: 10.1016/j.biopsych.2016.05.004.
- Kort NS, Ford JM, Roach BJ, Gunduz-Bruce H, Krystal JH, Jaeger J, Reinhart RM, Mathalon DH. Role of N-Methyl-D-Aspartate Receptors in Action-Based Predictive Coding Deficits in Schizophrenia. Biological Psychiatry 2016, 81: 514-524. PMID: 27647218, PMCID: PMC5203970, DOI: 10.1016/j.biopsych.2016.06.019.
- Krystal JH, Abi-Dargham A, Barch DM, Bullmore ET, Carter CS, Geschwind DH, Harrison PJ, Nestler EJ, Stein MB. Biological Psychiatry and Biological Psychiatry: Cognitive Neuroscience and Neuroimaging Adopt Neuroscience-Based Nomenclature. Biological Psychiatry 2016, 80: 2-3. PMID: 27312230, DOI: 10.1016/j.biopsych.2016.03.2103.
- Scott JC, Woods SP, Wrocklage KM, Schweinsburg BC, Southwick SM, Krystal JH. Prospective Memory in Posttraumatic Stress Disorder. Journal Of The International Neuropsychological Society 2016, 22: 724-734. PMID: 27353125, DOI: 10.1017/s1355617716000564.
- Sippel LM, Mota NP, Kachadourian LK, Krystal JH, Southwick SM, Harpaz-Rotem I, Pietrzak RH. The burden of hostility in U.S. Veterans: Results from the National Health and Resilience in Veterans Study. Psychiatry Research 2016, 243: 421-430. PMID: 27450745, DOI: 10.1016/j.psychres.2016.06.040.
- Krystal JH, Abi-Dargham A, Barch DM, Bullmore ET, Carter CS, Geschwind DH, Harrison PJ, Nestler EJ, Stein MB. Biological Psychiatry and Biological Psychiatry: Cognitive Neuroscience and Neuroimaging Adopt Neuroscience-Based Nomenclature. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2016, 1: 300-301. PMID: 29560862, DOI: 10.1016/j.bpsc.2016.03.007.
- Gerin MI, Fichtenholtz H, Roy A, Walsh CJ, Krystal JH, Southwick S, Hampson M. Real-Time fMRI Neurofeedback with War Veterans with Chronic PTSD: A Feasibility Study. Frontiers In Psychiatry 2016, 7: 111. PMID: 27445868, PMCID: PMC4914513, DOI: 10.3389/fpsyt.2016.00111.
- Otto MW, Pollack MH, Dowd SM, Hofmann SG, Pearlson G, Szuhany KL, Gueorguieva R, Krystal JH, Simon NM, Tolin DF. RANDOMIZED TRIAL OF D‐CYCLOSERINE ENHANCEMENT OF COGNITIVE‐BEHAVIORAL THERAPY FOR PANIC DISORDER. Depression And Anxiety 2016, 33: 737-745. PMID: 27315514, PMCID: PMC5958622, DOI: 10.1002/da.22531.
- Mota NP, Tsai J, Sareen J, Marx BP, Wisco BE, Harpaz-Rotem I, Southwick SM, Krystal JH, Pietrzak RH. High burden of subthreshold DSM‐5 post‐traumatic stress disorder in U.S. military veterans. World Psychiatry 2016, 15: 185-186. PMID: 27265715, PMCID: PMC4911785, DOI: 10.1002/wps.20313.
- Krystal J, Sanacora G, Abdallah C, Duman R. Speaker 4: John Krystal, USA. The International Journal Of Neuropsychopharmacology 2016, 19: 19-19. PMCID: PMC5616528, DOI: 10.1093/ijnp/pyw042.052.
- Fuehrlein BS, Mota N, Arias AJ, Trevisan LA, Kachadourian LK, Krystal JH, Southwick SM, Pietrzak RH. The burden of alcohol use disorders in US military veterans: results from the National Health and Resilience in Veterans Study. Addiction 2016, 111: 1786-1794. PMID: 27061707, DOI: 10.1111/add.13423.
- Murrough JW, Abdallah CG, Anticevic A, Collins KA, Geha P, Averill LA, Schwartz J, DeWilde KE, Averill C, Jia-Wei Yang G, Wong E, Tang CY, Krystal JH, Iosifescu DV, Charney DS. Reduced global functional connectivity of the medial prefrontal cortex in major depressive disorder. Human Brain Mapping 2016, 37: 3214-3223. PMID: 27144347, PMCID: PMC4980239, DOI: 10.1002/hbm.23235.
- Abdallah CG, Adams TG, Kelmendi B, Esterlis I, Sanacora G, Krystal JH. KETAMINE'S MECHANISM OF ACTION: A PATH TO RAPID‐ACTING ANTIDEPRESSANTS. Depression And Anxiety 2016, 33: 689-697. PMID: 27062302, PMCID: PMC4961540, DOI: 10.1002/da.22501.
- Watkins LE, Han S, Harpaz-Rotem I, Mota NP, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. FKBP5 polymorphisms, childhood abuse, and PTSD symptoms: Results from the National Health and Resilience in Veterans Study. Psychoneuroendocrinology 2016, 69: 98-105. PMID: 27078785, DOI: 10.1016/j.psyneuen.2016.04.001.
- Mota N, Tsai J, Kirwin PD, Harpaz-Rotem I, Krystal JH, Southwick SM, Pietrzak RH. Late-life exacerbation of PTSD symptoms in US veterans: results from the National Health and Resilience in Veterans Study. The Journal Of Clinical Psychiatry 2016, 77: 348-54. PMID: 27046308, DOI: 10.4088/jcp.15m10101.
- Duman RS, Aghajanian GK, Sanacora G, Krystal JH. Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nature Medicine 2016, 22: 238-249. PMID: 26937618, PMCID: PMC5405628, DOI: 10.1038/nm.4050.
- Wrocklage KM, Schweinsburg BC, Krystal JH, Trejo M, Roy A, Weisser V, Moore TM, Southwick SM, Scott JC. Neuropsychological Functioning in Veterans with Posttraumatic Stress Disorder: Associations with Performance Validity, Comorbidities, and Functional Outcomes. Journal Of The International Neuropsychological Society 2016, 22: 399-411. PMID: 26892753, DOI: 10.1017/s1355617716000059.
- Krystal JH. Neuroethology as a translational neuroscience strategy in the era of the NIMH Research Domain Criteria. Psychophysiology 2016, 53: 364-366. PMID: 26877127, PMCID: PMC4758465, DOI: 10.1111/psyp.12465.
- Rich AM, Cho YT, Tang Y, Savic A, Krystal JH, Wang F, Xu K, Anticevic A. Amygdala volume is reduced in early course schizophrenia. Psychiatry Research Neuroimaging 2016, 250: 50-60. PMID: 27035063, PMCID: PMC4904038, DOI: 10.1016/j.pscychresns.2016.02.006.
- Hu S, Zhang S, Chao HH, Krystal JH, Li CS. Association of Drinking Problems and Duration of Alcohol Use to Inhibitory Control in Nondependent Young Adult Social Drinkers. Alcohol Clinical And Experimental Research 2016, 40: 319-328. PMID: 26833431, PMCID: PMC4742397, DOI: 10.1111/acer.12964.
- Krystal JH, Pietrzak RH, Rosenheck RA, Cramer JA, Vessicchio J, Jones KM, Huang GD, Vertrees JE, Collins J, Krystal AD. Sleep disturbance in chronic military-related PTSD: clinical impact and response to adjunctive risperidone in the Veterans Affairs cooperative study #504. The Journal Of Clinical Psychiatry 2016, 77: 483-91. PMID: 26890894, DOI: 10.4088/jcp.14m09585.
- Southwick SM, Sippel L, Krystal J, Charney D, Mayes L, Pietrzak R. Why are some individuals more resilient than others: the role of social support. World Psychiatry 2016, 15: 77-79. PMID: 26833614, PMCID: PMC4780285, DOI: 10.1002/wps.20282.
- Chekroud AM, Zotti RJ, Shehzad Z, Gueorguieva R, Johnson MK, Trivedi MH, Cannon TD, Krystal JH, Corlett PR. Cross-trial prediction of treatment outcome in depression: a machine learning approach. The Lancet Psychiatry 2016, 3: 243-250. PMID: 26803397, DOI: 10.1016/s2215-0366(15)00471-x.
- Cavus I, Widi GA, Duckrow RB, Zaveri H, Kennard JT, Krystal J, Spencer DD. 50 Hz hippocampal stimulation in refractory epilepsy: Higher level of basal glutamate predicts greater release of glutamate. Epilepsia 2016, 57: 288-297. PMID: 26749134, DOI: 10.1111/epi.13269.
- Guille C, Zhao Z, Krystal J, Nichols B, Brady K, Sen S. Web-Based Cognitive Behavioral Therapy Intervention for the Prevention of Suicidal Ideation in Medical Interns: A Randomized Clinical Trial. Missouri Medicine 2016, 113: 19. PMID: 30228438, PMCID: PMC6139738.
- Abdallah CG, Averill LA, Krystal JH, Southwick SM, Arnsten AF. Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology. Behavioral And Brain Sciences 2016, 39: e201. PMID: 28347382, PMCID: PMC5485236, DOI: 10.1017/s0140525x15001727.
- Yang GJ, Murray JD, Wang XJ, Glahn DC, Pearlson GD, Repovs G, Krystal JH, Anticevic A. Functional hierarchy underlies preferential connectivity disturbances in schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 113: e219-e228. PMID: 26699491, PMCID: PMC4720350, DOI: 10.1073/pnas.1508436113.
- Krystal JH, Anticevic A. Toward Illness Phase–Specific Pharmacotherapy for Schizophrenia. Biological Psychiatry 2015, 78: 738-740. PMID: 26542740, DOI: 10.1016/j.biopsych.2015.08.017.
- Corbin WR, Papova A, Morean ME, O’Malley S, Krishnan-Sarin S, Abi-Dargham A, Anticevic A, Pearlson G, Petrakis I, Pittman BP, Krystal JH. Integrating Acquired Preparedness and Dual Process Models of Risk for Heavy Drinking and Related Problems. Psychology Of Addictive Behaviors 2015, 29: 864-874. PMID: 26348221, PMCID: PMC6223629, DOI: 10.1037/adb0000093.
- Guille C, Zhao Z, Krystal J, Nichols B, Brady K, Sen S. Web-Based Cognitive Behavioral Therapy Intervention for the Prevention of Suicidal Ideation in Medical Interns: A Randomized Clinical Trial. JAMA Psychiatry 2015, 72: 1-7. PMID: 26535958, PMCID: PMC4866804, DOI: 10.1001/jamapsychiatry.2015.1880.
- Licznerski P, Duric V, Banasr M, Alavian KN, Ota KT, Kang HJ, Jonas EA, Ursano R, Krystal JH, Duman RS, . Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic Stress. PLOS Biology 2015, 13: e1002282. PMID: 26506154, PMCID: PMC4623974, DOI: 10.1371/journal.pbio.1002282.
- Yoon G, Pittman B, Limoncelli D, Krystal JH, Petrakis IL. Familial Alcoholism Risk and the Ratio of Stimulant to Sedative Effects of Ketamine. Biological Psychiatry 2015, 79: e69-e70. PMID: 26475672, DOI: 10.1016/j.biopsych.2015.09.006.
- Southwick SM, Pietrzak RH, Charney DS, Krystal JH. Resilience: The role of accurate appraisal, thresholds, and socioenvironmental factors 1. Behavioral And Brain Sciences 2015, 38: e122. PMID: 26786005, DOI: 10.1017/s0140525x14001708.
- Zuo L, Tan Y, Zhang X, Wang X, Krystal J, Tabakoff B, Zhong C, Luo X. A New Genomewide Association Meta‐Analysis of Alcohol Dependence. Alcohol Clinical And Experimental Research 2015, 39: 1388-1395. PMID: 26173551, PMCID: PMC5587504, DOI: 10.1111/acer.12786.
- Stone J, Kotoula V, Dietrich C, De Simoni S, Krystal JH, Mehta MA. Perceptual distortions and delusional thinking following ketamine administration are related to increased pharmacological MRI signal changes in the parietal lobe. Journal Of Psychopharmacology 2015, 29: 1025-1028. PMID: 26152321, DOI: 10.1177/0269881115592337.
- Krystal JH, Stossel S, Krystal AD. Restricting Benzodiazepines to Short-Term Prescription. JAMA Psychiatry 2015, 72: 734-735. PMID: 25923129, DOI: 10.1001/jamapsychiatry.2015.0351.
- Zuo L, Saba L, Lin X, Tan Y, Wang K, Krystal JH, Tabakoff B, Luo X. Significant association between rare IPO11‐HTR1A variants and attention deficit hyperactivity disorder in Caucasians. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2015, 168: 544-556. PMID: 26079129, PMCID: PMC4851708, DOI: 10.1002/ajmg.b.32329.
- Chekroud AM, Krystal JH. Personalised pharmacotherapy: an interim solution for antidepressant treatment? The BMJ 2015, 350: h2502. PMID: 25976040, DOI: 10.1136/bmj.h2502.
- Ahn KH, Sewell A, Elander J, Pittman B, Ranganathan M, Gunduz-Bruce H, Krystal J, D'Souza DC. Role of GABA Deficit in Sensitivity to the Psychotomimetic Effects of Amphetamine. Neuropsychopharmacology 2015, 40: 2822-2831. PMID: 25953357, PMCID: PMC4864658, DOI: 10.1038/npp.2015.132.
- Lingjun Z, ZHANG CK, SAYWARD FG, CHEUNG KH, Kesheng W, KRYSTAL JH, Hongyu Z, Xingguang L. Gene-based and pathway-based genome-wide association study of alcohol dependence. General Psychiatry 2015, 27: 111-118. PMID: 26120261, PMCID: PMC4466852, DOI: 10.11919/j.issn.1002-0829.215031.
- Krystal JH, Carter CS. Introducing a New Journal: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. Biological Psychiatry 2015, 77: 922. PMID: 25959562, DOI: 10.1016/j.biopsych.2015.04.009.
- Abdallah C, Krystal J. Ketamine. 2015, 857-862. DOI: 10.1007/978-3-642-36172-2_7031.
- Pietrzak RH, Averill LA, Abdallah CG, Neumeister A, Krystal JH, Levy I, Harpaz-Rotem I. Amygdala-Hippocampal Volume and the Phenotypic Heterogeneity of Posttraumatic Stress Disorder: A Cross-Sectional Study. JAMA Psychiatry 2015, 72: 396-398. PMID: 25692480, PMCID: PMC5134909, DOI: 10.1001/jamapsychiatry.2014.2470.
- Krystal JH. Deconstructing N-Methyl-D-Aspartate Glutamate Receptor Contributions to Cortical Circuit Functions to Construct Better Hypotheses About the Pathophysiology of Schizophrenia. Biological Psychiatry 2015, 77: 508-510. PMID: 25687430, DOI: 10.1016/j.biopsych.2014.10.010.
- Abdallah CG, Averill LA, Krystal JH. Ketamine as a promising prototype for a new generation of rapid‐acting antidepressants. Annals Of The New York Academy Of Sciences 2015, 1344: 66-77. PMID: 25727103, PMCID: PMC4412785, DOI: 10.1111/nyas.12718.
- Krishnan‐Sarin S, O'Malley SS, Franco N, Cavallo DA, Morean M, Shi J, Pittman B, Krystal JH. N‐Methyl‐d‐Aspartate Receptor Antagonism has Differential Effects on Alcohol Craving and Drinking in Heavy Drinkers. Alcohol Clinical And Experimental Research 2015, 39: 300-307. PMID: 25664775, PMCID: PMC4331214, DOI: 10.1111/acer.12619.
- Krystal JH, O'Malley SS. From Translational Neuroscience to Personalized Medicine. Alcohol Clinical And Experimental Research 2015, 39: 585-586. PMID: 25656652, DOI: 10.1111/acer.12667.
- Anticevic A, Hu X, Xiao Y, Hu J, Li F, Bi F, Cole MW, Savic A, Yang GJ, Repovs G, Murray JD, Wang XJ, Huang X, Lui S, Krystal JH, Gong Q. Early-Course Unmedicated Schizophrenia Patients Exhibit Elevated Prefrontal Connectivity Associated with Longitudinal Change. Journal Of Neuroscience 2015, 35: 267-286. PMID: 25568120, PMCID: PMC4287147, DOI: 10.1523/jneurosci.2310-14.2015.
- Krystal JH. Biological Psychiatry: Looking Good! Biological Psychiatry 2015, 77: 2. PMID: 25483341, DOI: 10.1016/j.biopsych.2014.10.007.
- Scott JC, Matt GE, Wrocklage KM, Crnich C, Jordan J, Southwick SM, Krystal JH, Schweinsburg BC. A Quantitative Meta-Analysis of Neurocognitive Functioning in Posttraumatic Stress Disorder. Psychological Bulletin 2015, 141: 105-140. PMID: 25365762, PMCID: PMC4293317, DOI: 10.1037/a0038039.
- Xu K, Krystal JH, Ning Y, Chen da C, He H, Wang D, Ke X, Zhang X, Ding Y, Liu Y, Gueorguieva R, Wang Z, Limoncelli D, Pietrzak RH, Petrakis IL, Zhang X, Fan N. Preliminary analysis of positive and negative syndrome scale in ketamine-associated psychosis in comparison with schizophrenia. Journal Of Psychiatric Research 2014, 61: 64-72. PMID: 25560772, PMCID: PMC4445679, DOI: 10.1016/j.jpsychires.2014.12.012.
- Cosgrove KP, McKay R, Esterlis I, Kloczynski T, Perkins E, Bois F, Pittman B, Lancaster J, Glahn DC, O’Malley S, Carson RE, Krystal JH. Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 18031-18036. PMID: 25453062, PMCID: PMC4273348, DOI: 10.1073/pnas.1413947111.
- Saricicek A, Chen J, Planeta B, Ruf B, Subramanyam K, Maloney K, Matuskey D, Labaree D, Deserno L, Neumeister A, Krystal JH, Gallezot JD, Huang Y, Carson RE, Bhagwagar Z. Test–retest reliability of the novel 5-HT1B receptor PET radioligand [11C]P943. European Journal Of Nuclear Medicine And Molecular Imaging 2014, 42: 468-477. PMID: 25427881, DOI: 10.1007/s00259-014-2958-5.
- Tsai J, Harpaz-Rotem I, Armour C, Southwick SM, Krystal JH, Pietrzak RH. Dimensional structure of DSM-5 posttraumatic stress disorder symptoms: results from the National Health and Resilience in Veterans Study. The Journal Of Clinical Psychiatry 2014, 76: 546-53. PMID: 25562376, DOI: 10.4088/jcp.14m09091.
- Wang XJ, Krystal JH. Computational Psychiatry. Neuron 2014, 84: 638-654. PMID: 25442941, PMCID: PMC4255477, DOI: 10.1016/j.neuron.2014.10.018.
- Abdallah CG, Jiang L, De Feyter HM, Fasula M, Krystal JH, Rothman DL, Mason GF, Sanacora G. Glutamate Metabolism in Major Depressive Disorder. American Journal Of Psychiatry 2014, 171: 1320-1327. PMID: 25073688, PMCID: PMC4472484, DOI: 10.1176/appi.ajp.2014.14010067.
- Pietrzak RH, Rosenheck RA, Cramer JA, Vessichio JC, Tsai J, Southwick SM, Krystal JH, Group F. Elucidating the transdiagnostic dimensional structure of trauma-related psychopathology: Findings from VA cooperative study 504 – risperidone treatment for military service related chronic post traumatic stress disorder. Journal Of Affective Disorders 2014, 172: 331-336. PMID: 25451434, DOI: 10.1016/j.jad.2014.10.025.
- Abdallah CG, Sanacora G, Duman RS, Krystal JH. Ketamine and Rapid-Acting Antidepressants: A Window into a New Neurobiology for Mood Disorder Therapeutics. Annual Review Of Medicine 2014, 66: 1-15. PMID: 25341010, PMCID: PMC4428310, DOI: 10.1146/annurev-med-053013-062946.
- Morean ME, DeMartini KS, Leeman RF, Pearlson GD, Anticevic A, Krishnan-Sarin S, Krystal JH, O’Malley S. Psychometrically Improved, Abbreviated Versions of Three Classic Measures of Impulsivity and Self-Control. Psychological Assessment 2014, 26: 1003-1020. PMID: 24885848, PMCID: PMC4152397, DOI: 10.1037/pas0000003.
- Anticevic A, Corlett PR, Cole MW, Savic A, Gancsos M, Tang Y, Repovs G, Murray JD, Driesen NR, Morgan PT, Xu K, Wang F, Krystal JH. N-Methyl-D-Aspartate Receptor Antagonist Effects on Prefrontal Cortical Connectivity Better Model Early Than Chronic Schizophrenia. Biological Psychiatry 2014, 77: 569-580. PMID: 25281999, DOI: 10.1016/j.biopsych.2014.07.022.
- Gallezot J, Esterlis I, Bois F, Zheng M, Lin S, Kloczynski T, Krystal JH, Huang Y, Sabri O, Carson RE, Cosgrove KP. Evaluation of the sensitivity of the novel α4β2* nicotinic acetylcholine receptor PET radioligand 18F‐(‐)‐NCFHEB to increases in synaptic acetylcholine levels in rhesus monkeys. Synapse 2014, 68: 556-564. PMID: 25043426, PMCID: PMC4224280, DOI: 10.1002/syn.21767.
- In Vivo Ketamine-Induced Changes in [11C]ABP688 Binding to Metabotropic Glutamate Receptor Subtype 5DeLorenzo C, DellaGioia N, Bloch M, Sanacora G, Nabulsi N, Abdallah C, Yang J, Wen R, Mann JJ, Krystal JH, Parsey RV, Carson RE, Esterlis I. In Vivo Ketamine-Induced Changes in [11C]ABP688 Binding to Metabotropic Glutamate Receptor Subtype 5. Biological Psychiatry 2014, 77: 266-275. PMID: 25156701, PMCID: PMC4277907, DOI: 10.1016/j.biopsych.2014.06.024.
- Baldan L, Williams K, Gallezot J, Pogorelov V, Rapanelli M, Crowley M, Anderson G, Loring E, Gorczyca R, Billingslea E, Wasylink S, Panza K, Ercan-Sencicek A, Krusong K, Leventhal B, Ohtsu H, Bloch M, Hughes Z, Krystal J, Mayes L, de Araujo I, Ding Y, State M, Pittenger C. Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice. Neuron 2014, 82: 1186-1187. DOI: 10.1016/j.neuron.2014.05.023.
- Abdallah C, Krystal J. Ketamine. 2014, 1-6. DOI: 10.1007/978-3-642-27772-6_7031-1.
- Yang GJ, Murray JD, Repovs G, Cole MW, Savic A, Glasser MF, Pittenger C, Krystal JH, Wang XJ, Pearlson GD, Glahn DC, Anticevic A. Altered global brain signal in schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 7438-7443. PMID: 24799682, PMCID: PMC4034208, DOI: 10.1073/pnas.1405289111.
- Anticevic A, Savic A, Repovs G, Yang G, McKay DR, Sprooten E, Knowles EE, Krystal JH, Pearlson GD, Glahn DC. Ventral Anterior Cingulate Connectivity Distinguished Nonpsychotic Bipolar Illness From Psychotic Bipolar Disorder and Schizophrenia. Schizophrenia Bulletin 2014, 41: 133-143. PMID: 24782562, PMCID: PMC4266289, DOI: 10.1093/schbul/sbu051.
- Anticevic A, Murray J, Repovs G, Starc M, Santamauro N, Savic A, Morgan P, Wang X, Krystal J. 5:45 PM INTEGRATING PHARMACOLOGY AND COMPUTATION: TOWARDS UNDERSTANDING MECHANISMS OF COGNITIVE AND CONNECTIVITY DEFICITS IN SCHIZOPHRENIA. Schizophrenia Research 2014, 153: s52-s53. DOI: 10.1016/s0920-9964(14)70172-0.
- Rosenheck R, Leatherman S, Krystal J, Liang M. Poster #T200 SUBGROUP ANALYSIS IN A RANDOMIZED CLINICAL TRIAL OF LONG-ACTING INJECTABLE RISPERIDONE AND ORAL ANTIPSYCHOTICS IN UNSTABLE CHRONIC SCHIZOPHRENIA. Schizophrenia Research 2014, 153: s360. DOI: 10.1016/s0920-9964(14)71016-3.
- Krystal JH, State MW. Psychiatric Disorders: Diagnosis to Therapy. Cell 2014, 157: 201-214. PMID: 24679536, PMCID: PMC4104191, DOI: 10.1016/j.cell.2014.02.042.
- Stefanovics EA, Krystal JH, Rosenheck RA. Symptom structure and severity: A comparison of responses to the positive and negative syndrome scale (PANSS) between patients with PTSD or schizophrenia. Comprehensive Psychiatry 2014, 55: 887-895. PMID: 24602497, DOI: 10.1016/j.comppsych.2014.01.014.
- Baldan LC, Williams KA, Gallezot JD, Pogorelov V, Rapanelli M, Crowley M, Anderson GM, Loring E, Gorczyca R, Billingslea E, Wasylink S, Panza KE, Ercan-Sencicek AG, Krusong K, Leventhal BL, Ohtsu H, Bloch MH, Hughes ZA, Krystal JH, Mayes L, de Araujo I, Ding YS, State MW, Pittenger C. Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice. Neuron 2014, 81: 77-90. PMID: 24411733, PMCID: PMC3894588, DOI: 10.1016/j.neuron.2013.10.052.
- Boggs DL, Carlson J, Cortes-Briones J, Krystal JH, D'Souza DC. Going up in smoke? A review of nAChRs-based treatment strategies for improving cognition in schizophrenia. Current Pharmaceutical Design 2014, 20: 5077-92. PMID: 24345265, PMCID: PMC4442779, DOI: 10.2174/1381612819666131216121019.
- Leatherman SM, Liang MH, Krystal JH, Lew RA, Valley D, Thwin SS, Rosenheck RA. Differences in Treatment Effect Among Clinical Subgroups in a Randomized Clinical Trial of Long-Acting Injectable Risperidone and Oral Antipsychotics in Unstable Chronic Schizophrenia. The Journal Of Nervous And Mental Disease 2014, 202: 13-17. PMID: 24375206, DOI: 10.1097/nmd.0000000000000069.
- Anticevic A, Tang Y, Cho YT, Repovs G, Cole MW, Savic A, Wang F, Krystal JH, Xu K. Amygdala Connectivity Differs Among Chronic, Early Course, and Individuals at Risk for Developing Schizophrenia. Schizophrenia Bulletin 2013, 40: 1105-1116. PMID: 24366718, PMCID: PMC4133672, DOI: 10.1093/schbul/sbt165.
- Zuo L, Wang K, Zhang X, Pan X, Wang G, Krystal JH, Zhang H, Luo X. Sex chromosome-wide association analysis suggested male-specific risk genes for alcohol dependence. Psychiatric Genetics 2013, 23: 233-238. PMID: 23907288, PMCID: PMC3941913, DOI: 10.1097/ypg.0b013e328364b8c7.
- Anticevic A, Hu S, Zhang S, Savic A, Billingslea E, Wasylink S, Repovs G, Cole MW, Bednarski S, Krystal JH, Bloch MH, Li CS, Pittenger C. Global Resting-State Functional Magnetic Resonance Imaging Analysis Identifies Frontal Cortex, Striatal, and Cerebellar Dysconnectivity in Obsessive-Compulsive Disorder. Biological Psychiatry 2013, 75: 595-605. PMID: 24314349, PMCID: PMC3969771, DOI: 10.1016/j.biopsych.2013.10.021.
- Pietrzak RH, Gallezot JD, Ding YS, Henry S, Potenza MN, Southwick SM, Krystal JH, Carson RE, Neumeister A. Association of Posttraumatic Stress Disorder With Reduced In Vivo Norepinephrine Transporter Availability in the Locus Coeruleus. JAMA Psychiatry 2013, 70: 1199-1205. PMID: 24048210, PMCID: PMC4026855, DOI: 10.1001/jamapsychiatry.2013.399.
- Krystal J. Pl.2 - KETAMINE. Behavioural Pharmacology 2013, 24: e1. DOI: 10.1097/01.fbp.0000434680.00108.7d.
- Krystal J. S.19.04 Glutamatergic contributions to reward dysfunction in alcohol dependence. European Neuropsychopharmacology 2013, 23: s141. DOI: 10.1016/s0924-977x(13)70198-6.
- Krystal JH. Biological Psychiatry: Raising the Bar. Biological Psychiatry 2013, 74: 476-477. PMID: 24034363, DOI: 10.1016/j.biopsych.2013.07.034.
- Holmes A, Spanagel R, Krystal JH. Glutamatergic targets for new alcohol medications. Psychopharmacology 2013, 229: 539-554. PMID: 23995381, PMCID: PMC3811052, DOI: 10.1007/s00213-013-3226-2.
- Zuo L, Wang KS, Zhang XY, Li CS, Zhang F, Wang X, Chen W, Gao G, Zhang H, Krystal JH, Luo X. Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent. Pharmacogenetics And Genomics 2013, 23: 395-402. PMID: 23778322, PMCID: PMC4287355, DOI: 10.1097/fpc.0b013e328362f9f2.
- Xie P, Kranzler HR, Krystal JH, Farrer LA, Zhao H, Gelernter J. Deep resequencing of 17 glutamate system genes identifies rare variants in DISC1 and GRIN2B affecting risk of opioid dependence. Addiction Biology 2013, 19: 955-964. PMID: 23855403, PMCID: PMC3815683, DOI: 10.1111/adb.12072.
- Driesen NR, McCarthy G, Bhagwagar Z, Bloch MH, Calhoun VD, D'Souza DC, Gueorguieva R, He G, Leung HC, Ramani R, Anticevic A, Suckow RF, Morgan PT, Krystal JH. The Impact of NMDA Receptor Blockade on Human Working Memory-Related Prefrontal Function and Connectivity. Neuropsychopharmacology 2013, 38: 2613-2622. PMID: 23856634, PMCID: PMC3828532, DOI: 10.1038/npp.2013.170.
- Anticevic A, Cole MW, Repovs G, Murray JD, Brumbaugh MS, Winkler AM, Savic A, Krystal JH, Pearlson GD, Glahn DC. Characterizing Thalamo-Cortical Disturbances in Schizophrenia and Bipolar Illness. Cerebral Cortex 2013, 24: 3116-3130. PMID: 23825317, PMCID: PMC4224238, DOI: 10.1093/cercor/bht165.
- Zuo L, Saba L, Wang K, Zhang X, Krystal JH, Tabakoff B, Luo X. Exome-wide association study of replicable nonsynonymous variants conferring risk for alcohol dependence. Journal Of Studies On Alcohol And Drugs 2013, 74: 622-5. PMID: 23739027, PMCID: PMC3711352, DOI: 10.15288/jsad.2013.74.622.
- Corlett PR, Cambridge V, Gardner JM, Piggot JS, Turner DC, Everitt JC, Arana FS, Morgan HL, Milton AL, Lee JL, Aitken MR, Dickinson A, Everitt BJ, Absalom AR, Adapa R, Subramanian N, Taylor JR, Krystal JH, Fletcher PC. Ketamine Effects on Memory Reconsolidation Favor a Learning Model of Delusions. PLOS ONE 2013, 8: e65088. PMID: 23776445, PMCID: PMC3680467, DOI: 10.1371/journal.pone.0065088.
- Krystal JH, Sanacora G, Duman RS. Rapid-Acting Glutamatergic Antidepressants: The Path to Ketamine and Beyond. Biological Psychiatry 2013, 73: 1133-1141. PMID: 23726151, PMCID: PMC3671489, DOI: 10.1016/j.biopsych.2013.03.026.
- DeVito EE, Meda SA, Jiantonio R, Potenza MN, Krystal JH, Pearlson GD. Neural Correlates of Impulsivity in Healthy Males and Females with Family Histories of Alcoholism. Neuropsychopharmacology 2013, 38: 1854-1863. PMID: 23584260, PMCID: PMC3746701, DOI: 10.1038/npp.2013.92.
- Jiang L, Gulanski BI, De Feyter HM, Weinzimer SA, Pittman B, Guidone E, Koretski J, Harman S, Petrakis IL, Krystal JH, Mason GF. Increased brain uptake and oxidation of acetate in heavy drinkers. Journal Of Clinical Investigation 2013, 123: 1605-1614. PMID: 23478412, PMCID: PMC3613911, DOI: 10.1172/jci65153.
- Zuo L, Wang K, Zhang XY, Pan X, Wang G, Tan Y, Zhong C, Krystal JH, State M, Zhang H, Luo X. Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism. Human Genetics 2013, 132: 735-743. PMID: 23468174, PMCID: PMC3683370, DOI: 10.1007/s00439-013-1277-4.
- Narayanan B, Stevens MC, Jiantonio RE, Krystal JH, Pearlson GD. Effects of memantine on event-related potential, oscillations, and complexity in individuals with and without family histories of alcoholism. Journal Of Studies On Alcohol And Drugs 2013, 74: 245-57. PMID: 23384372, PMCID: PMC3568163, DOI: 10.15288/jsad.2013.74.245.
- Zuo L, Wang K, Zhang XY, Krystal JH, Li CS, Zhang F, Zhang H, Luo X. NKAIN1–SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent. Drug And Alcohol Dependence 2013, 129: 254-264. PMID: 23455491, PMCID: PMC3628730, DOI: 10.1016/j.drugalcdep.2013.02.006.
- Gueorguieva R, Wu R, Krystal JH, Donovan D, O'Malley SS. Temporal patterns of adherence to medications and behavioral treatment and their relationship to patient characteristics and treatment response. Addictive Behaviors 2013, 38: 2119-2127. PMID: 23435273, PMCID: PMC3595348, DOI: 10.1016/j.addbeh.2013.01.024.
- Anticevic A, Krystal J, Barch D. Translational cognitive neuroscience of schizophrenia: bridging neurocognitive and computational approaches toward understanding cognitive deficits. 2013, 193-230. DOI: 10.1017/cbo9781139003872.013.
- Driesen NR, McCarthy G, Bhagwagar Z, Bloch M, Calhoun V, D'Souza DC, Gueorguieva R, He G, Ramachandran R, Suckow RF, Anticevic A, Morgan PT, Krystal JH. Relationship of resting brain hyperconnectivity and schizophrenia-like symptoms produced by the NMDA receptor antagonist ketamine in humans. Molecular Psychiatry 2013, 18: 1199-1204. PMID: 23337947, PMCID: PMC3646075, DOI: 10.1038/mp.2012.194.
- Anticevic A, Cole MW, Repovs G, Savic A, Driesen NR, Yang G, Cho YT, Murray JD, Glahn DC, Wang XJ, Krystal JH. Connectivity, Pharmacology, and Computation: Toward a Mechanistic Understanding of Neural System Dysfunction in Schizophrenia. Frontiers In Psychiatry 2013, 4: 169. PMID: 24399974, PMCID: PMC3871997, DOI: 10.3389/fpsyt.2013.00169.
- Insel T, Krystal J, Ehlers M. New drug development for cognitive enhancement in mental health: Challenges and opportunities. Neuropharmacology 2013, 64: 2-7. PMID: 23145450, DOI: 10.1016/j.neuropharm.2012.07.041.
- Zuo L, Zhang X, Wang F, Li C, Lu L, Ye L, Zhang H, Krystal JH, Deng H, Luo X. Genome‐Wide Significant Association Signals in IPO11‐HTR1A Region Specific for Alcohol and Nicotine Codependence. Alcohol Clinical And Experimental Research 2012, 37: 730-739. PMID: 23216389, PMCID: PMC3610804, DOI: 10.1111/acer.12032.
- Murray JD, Anticevic A, Gancsos M, Ichinose M, Corlett PR, Krystal JH, Wang XJ. Linking Microcircuit Dysfunction to Cognitive Impairment: Effects of Disinhibition Associated with Schizophrenia in a Cortical Working Memory Model. Cerebral Cortex 2012, 24: 859-872. PMID: 23203979, PMCID: PMC3948492, DOI: 10.1093/cercor/bhs370.
- Anticevic A, Cole MW, Murray JD, Corlett PR, Wang XJ, Krystal JH. The role of default network deactivation in cognition and disease. Trends In Cognitive Sciences 2012, 16: 584-592. PMID: 23142417, PMCID: PMC3501603, DOI: 10.1016/j.tics.2012.10.008.
- Fryer SL, Jorgensen KW, Yetter EJ, Daurignac EC, Watson TD, Shanbhag H, Krystal JH, Mathalon DH. Differential brain response to alcohol cue distractors across stages of alcohol dependence. Biological Psychology 2012, 92: 282-291. PMID: 23131612, PMCID: PMC3947923, DOI: 10.1016/j.biopsycho.2012.10.004.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: Report of two pilot studies. European Neuropsychopharmacology 2012, 23: 931-940. PMID: 23089076, PMCID: PMC4028140, DOI: 10.1016/j.euroneuro.2012.09.008.
- Zuo L, Zhang H, Malison RT, Li CS, Zhang XY, Wang F, Lu L, Lu L, Wang X, Krystal JH, Zhang F, Deng HW, Luo X. Rare ADH Variant Constellations are Specific for Alcohol Dependence. Alcohol And Alcoholism 2012, 48: 9-14. PMID: 23019235, PMCID: PMC3523382, DOI: 10.1093/alcalc/ags104.
- Anticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ, Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH, Corlett PR. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16720-16725. PMID: 23012427, PMCID: PMC3478611, DOI: 10.1073/pnas.1208494109.
- Anticevic A, Brumbaugh MS, Winkler AM, Lombardo LE, Barrett J, Corlett PR, Kober H, Gruber J, Repovs G, Cole MW, Krystal JH, Pearlson GD, Glahn DC. Global Prefrontal and Fronto-Amygdala Dysconnectivity in Bipolar I Disorder with Psychosis History. Biological Psychiatry 2012, 73: 565-573. PMID: 22980587, PMCID: PMC3549314, DOI: 10.1016/j.biopsych.2012.07.031.
- Moghaddam B, Krystal JH. Capturing the Angel in “Angel Dust”: Twenty Years of Translational Neuroscience Studies of NMDA Receptor Antagonists in Animals and Humans. Schizophrenia Bulletin 2012, 38: 942-949. PMID: 22899397, PMCID: PMC3446228, DOI: 10.1093/schbul/sbs075.
- Anticevic A, Repovs G, Krystal JH, Barch DM. A broken filter: Prefrontal functional connectivity abnormalities in schizophrenia during working memory interference. Schizophrenia Research 2012, 141: 8-14. PMID: 22863548, PMCID: PMC3879404, DOI: 10.1016/j.schres.2012.07.007.
- Bloch MH, Wasylink S, Landeros-Weisenberger A, Panza KE, Billingslea E, Leckman JF, Krystal JH, Bhagwagar Z, Sanacora G, Pittenger C. Effects of Ketamine in Treatment-Refractory Obsessive-Compulsive Disorder. Biological Psychiatry 2012, 72: 964-970. PMID: 22784486, PMCID: PMC3667652, DOI: 10.1016/j.biopsych.2012.05.028.
- Nestler EJ, Krystal JH. Planning the New National Institute on Substance Use and Addiction Disorders. Biological Psychiatry 2012, 72: 166-167. PMID: 22683089, DOI: 10.1016/j.biopsych.2012.05.011.
- Krystal JH. Enhancing Prolonged Exposure Therapy for Posttraumatic Stress Disorder with D-Cycloserine: Further Support for Treatments That Promote Experience-Dependent Neuroplasticity. Biological Psychiatry 2012, 71: 932-934. PMID: 22579302, DOI: 10.1016/j.biopsych.2012.03.031.
- Pietrzak RH, Henry S, Southwick SM, Krystal JH, Neumeister A. Linking in vivo brain serotonin type 1B receptor density to phenotypic heterogeneity of posttraumatic stress symptomatology. Molecular Psychiatry 2012, 18: 399-401. PMID: 22584868, DOI: 10.1038/mp.2012.60.
- Barnett PG, Scott JY, Krystal JH, Rosenheck RA. Cost and cost-effectiveness in a randomized trial of long-acting risperidone for schizophrenia. The Journal Of Clinical Psychiatry 2012, 73: 696-702. PMID: 22697193, DOI: 10.4088/jcp.11m07070.
- Hyatt CJ, Assaf M, Muska CE, Rosen RI, Thomas AD, Johnson MR, Hylton JL, Andrews MM, Reynolds BA, Krystal JH, Potenza MN, Pearlson GD. Reward-Related Dorsal Striatal Activity Differences between Former and Current Cocaine Dependent Individuals during an Interactive Competitive Game. PLOS ONE 2012, 7: e34917. PMID: 22606228, PMCID: PMC3351439, DOI: 10.1371/journal.pone.0034917.
- Zuo L, Zhang F, Zhang H, Zhang X, Wang F, Li C, Lu L, Hong J, Lu L, Krystal J, Deng H, Luo X. Genome‐wide search for replicable risk gene regions in alcohol and nicotine co‐dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2012, 159B: 437-444. PMID: 22488850, PMCID: PMC3405545, DOI: 10.1002/ajmg.b.32047.
- Stone J, Dietrich C, Edden R, Mehta M, De Simoni S, Reed L, Krystal J, Nutt D, Barker G. P.3.001 Ketamine-induced changes in anterior cingulate glutamate levels correlate with positive symptom generation. European Neuropsychopharmacology 2012, 22: s52-s53. DOI: 10.1016/s0924-977x(12)70054-8.
- Pietrzak RH, Maruff P, Woodward M, Fredrickson J, Fredrickson A, Krystal JH, Southwick SM, Darby D. Mild Worry Symptoms Predict Decline in Learning and Memory in Healthy Older Adults: A 2-Year Prospective Cohort Study. American Journal Of Geriatric Psychiatry 2012, 20: 266-275. PMID: 22354117, PMCID: PMC3285262, DOI: 10.1097/jgp.0b013e3182107e24.
- Çavuş I, Reinhart RM, Roach BJ, Gueorguieva R, Teyler TJ, Clapp WC, Ford JM, Krystal JH, Mathalon DH. Impaired Visual Cortical Plasticity in Schizophrenia. Biological Psychiatry 2012, 71: 512-520. PMID: 22364738, PMCID: PMC3292767, DOI: 10.1016/j.biopsych.2012.01.013.
- Jamadar S, DeVito EE, Jiantonio RE, Meda SA, Stevens MC, Potenza MN, Krystal JH, Pearlson GD. Memantine, an NMDA receptor antagonist, differentially influences Go/No-Go performance and fMRI activity in individuals with and without a family history of alcoholism. Psychopharmacology 2012, 222: 129-140. PMID: 22311382, PMCID: PMC3674025, DOI: 10.1007/s00213-011-2628-2.
- Stone JM, Dietrich C, Edden R, Mehta MA, De Simoni S, Reed LJ, Krystal JH, Nutt D, Barker GJ. Ketamine effects on brain GABA and glutamate levels with 1H-MRS: relationship to ketamine-induced psychopathology. Molecular Psychiatry 2012, 17: 664-665. PMID: 22212598, PMCID: PMC3883303, DOI: 10.1038/mp.2011.171.
- Steine IM, Krystal JH, Nordhus IH, Bjorvatn B, Harvey AG, Eid J, Grønli J, Milde AM, Pallesen S. Insomnia, Nightmare Frequency, and Nightmare Distress in Victims of Sexual Abuse. Journal Of Interpersonal Violence 2011, 27: 1827-1843. PMID: 22204947, DOI: 10.1177/0886260511430385.
- Zuo L, Gelernter J, Zhang C, Zhao H, Lu L, Kranzler H, Malison R, Li C, Wang F, Zhang X, Deng H, Krystal J, Zhang F, Luo X. Erratum: Genome-Wide Association Study of Alcohol Dependence Implicates KIAA0040 on Chromosome 1q. Neuropsychopharmacology 2011, 37: 581-582. PMCID: PMC3242324, DOI: 10.1038/npp.2011.271.
- Kaffman A, Krystal J. New Frontiers in Animal Research of Psychiatric Illness. Methods In Molecular Biology 2011, 829: 3-30. PMID: 22231804, PMCID: PMC3337084, DOI: 10.1007/978-1-61779-458-2_1.
- Kaffman A, Krystal J. Erratum: New Frontiers in Animal Research of Psychiatric Illness. Methods In Molecular Biology 2011, 829: e1-e1. DOI: 10.1007/978-1-61779-458-2_38.
- Gueorguieva R, Mallinckrodt C, Krystal JH. Trajectories of Depression Severity in Clinical Trials of Duloxetine: Insights Into Antidepressant and Placebo Responses. JAMA Psychiatry 2011, 68: 1227-1237. PMID: 22147842, PMCID: PMC3339151, DOI: 10.1001/archgenpsychiatry.2011.132.
- Murrough JW, Huang Y, Hu J, Henry S, Williams W, Gallezot JD, Bailey CR, Krystal JH, Carson RE, Neumeister A. Reduced Amygdala Serotonin Transporter Binding in Posttraumatic Stress Disorder. Biological Psychiatry 2011, 70: 1033-1038. PMID: 21855859, PMCID: PMC3207037, DOI: 10.1016/j.biopsych.2011.07.003.
- Petrakis IL, Ralevski E, Desai N, Trevisan L, Gueorguieva R, Rounsaville B, Krystal JH. Noradrenergic vs Serotonergic Antidepressant with or without Naltrexone for Veterans with PTSD and Comorbid Alcohol Dependence. Neuropsychopharmacology 2011, 37: 996-1004. PMID: 22089316, PMCID: PMC3280636, DOI: 10.1038/npp.2011.283.
- Zuo L, Zhang CK, Wang F, Li CS, Zhao H, Lu L, Zhang XY, Lu L, Zhang H, Zhang F, Krystal JH, Luo X. A Novel, Functional and Replicable Risk Gene Region for Alcohol Dependence Identified by Genome-Wide Association Study. PLOS ONE 2011, 6: e26726. PMID: 22096494, PMCID: PMC3210123, DOI: 10.1371/journal.pone.0026726.
- Urban NB, Slifstein M, Meda S, Xu X, Ayoub R, Medina O, Pearlson GD, Krystal JH, Abi-Dargham A. Imaging human reward processing with positron emission tomography and functional magnetic resonance imaging. Psychopharmacology 2011, 221: 67-77. PMID: 22052081, DOI: 10.1007/s00213-011-2543-6.
- Gunduz-Bruce H, Reinhart RM, Roach BJ, Gueorguieva R, Oliver S, D'Souza DC, Ford JM, Krystal JH, Mathalon DH. Glutamatergic Modulation of Auditory Information Processing in the Human Brain. Biological Psychiatry 2011, 71: 969-977. PMID: 22036036, PMCID: PMC3290754, DOI: 10.1016/j.biopsych.2011.09.031.
- Marder SR, Roth B, Sullivan PF, Scolnick EM, Nestler EJ, Geyer MA, Welnberger DR, Karayiorgou M, Guidotti A, Gingrich J, Akbarian S, Buchanan RW, Lieberman JA, Conn PJ, Haggarty SJ, Law AJ, Campbell B, Krystal JH, Moghaddam B, Saw A, Caron MG, George SR, Allen JA, Solis M. Advancing drug discovery for schizophrenia. Annals Of The New York Academy Of Sciences 2011, 1236: 30-43. PMID: 22032400, PMCID: PMC3787879, DOI: 10.1111/j.1749-6632.2011.06216.x.
- Zuo L, Gelernter J, Zhang CK, Zhao H, Lu L, Kranzler HR, Malison RT, Li CS, Wang F, Zhang XY, Deng HW, Krystal JH, Zhang F, Luo X. Genome-Wide Association Study of Alcohol Dependence Implicates KIAA0040 on Chromosome 1q. Neuropsychopharmacology 2011, 37: 557-566. PMID: 21956439, DOI: 10.1038/npp.2011.229.
- Gueorguieva R, Wu R, Donovan D, Rounsaville BJ, Couper D, Krystal JH, O’Malley S. Baseline trajectories of heavy drinking and their effects on postrandomization drinking in the COMBINE Study: empirically derived predictors of drinking outcomes during treatment. Alcohol 2011, 46: 121-131. PMID: 21925828, PMCID: PMC3266454, DOI: 10.1016/j.alcohol.2011.08.008.
- Murrough JW, Czermak C, Henry S, Nabulsi N, Gallezot JD, Gueorguieva R, Planeta-Wilson B, Krystal JH, Neumaier JF, Huang Y, Ding YS, Carson RE, Neumeister A. The Effect of Early Trauma Exposure on Serotonin Type 1B Receptor Expression Revealed by Reduced Selective Radioligand Binding. JAMA Psychiatry 2011, 68: 892-900. PMID: 21893657, PMCID: PMC3244836, DOI: 10.1001/archgenpsychiatry.2011.91.
- Gomez R, Behar KL, Watzl J, Weinzimer SA, Gulanski B, Sanacora G, Koretski J, Guidone E, Jiang L, Petrakis IL, Pittman B, Krystal JH, Mason GF. Intravenous Ethanol Infusion Decreases Human Cortical γ-Aminobutyric Acid and N-Acetylaspartate as Measured with Proton Magnetic Resonance Spectroscopy at 4 Tesla. Biological Psychiatry 2011, 71: 239-246. PMID: 21855054, PMCID: PMC3227760, DOI: 10.1016/j.biopsych.2011.06.026.
- Krystal JH, Rosenheck RA, Cramer JA, Vessicchio JC, Jones KM, Vertrees JE, Horney RA, Huang GD, Stock C, Group F. Adjunctive Risperidone Treatment for Antidepressant-Resistant Symptoms of Chronic Military Service–Related PTSD: A Randomized Trial. JAMA 2011, 306: 493-502. PMID: 21813427, DOI: 10.1001/jama.2011.1080.
- Freeman WM, VanGuilder HD, Guidone E, Krystal JH, Grant KA, Vrana KE. Plasma proteomic alterations in non-human primates and humans after chronic alcohol self-administration. The International Journal Of Neuropsychopharmacology 2011, 14: 899-911. PMID: 21303580, PMCID: PMC3107900, DOI: 10.1017/s1461145711000046.
- Krystal J. Biological Psychiatry: A Time of Opportunity, a Time of Challenge. Biological Psychiatry 2011, 70: 3-4. DOI: 10.1016/j.biopsych.2011.04.020.
- Xie P, Kranzler HR, Krauthammer M, Cosgrove KP, Oslin D, Anton RF, Farrer LA, Picciotto MR, Krystal JH, Zhao H, Gelernter J. Rare Nonsynonymous Variants in Alpha-4 Nicotinic Acetylcholine Receptor Gene Protect Against Nicotine Dependence. Biological Psychiatry 2011, 70: 528-536. PMID: 21683344, PMCID: PMC3199609, DOI: 10.1016/j.biopsych.2011.04.017.
- Steine IM, Harvey AG, Krystal JH, Milde AM, Grønli J, Bjorvatn B, Nordhus IH, Eid J, Pallesen S. Sleep disturbances in sexual abuse victims: A systematic review. Sleep Medicine Reviews 2011, 16: 15-25. PMID: 21600813, DOI: 10.1016/j.smrv.2011.01.006.
- Carter CS, Barch DM, Bullmore E, Breiling J, Buchanan RW, Butler P, Cohen JD, Geyer M, Gollub R, Green MF, Jaeger J, Krystal JH, Moore H, Nuechterlein K, Robbins T, Silverstein S, Smith EE, Strauss M, Wykes T. Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia II: Developing Imaging Biomarkers to Enhance Treatment Development for Schizophrenia and Related Disorders. Biological Psychiatry 2011, 70: 7-12. PMID: 21529781, PMCID: PMC3116022, DOI: 10.1016/j.biopsych.2011.01.041.
- Soyka M, Kranzler HR, van den Brink W, Krystal J, Möller HJ, Kasper S, Treatment G. The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Substance Use and Related Disorders. Part 2: Opioid dependence. The World Journal Of Biological Psychiatry 2011, 12: 160-187. PMID: 21486104, DOI: 10.3109/15622975.2011.561872.
- Rosenheck RA, Krystal JH, Lew R, Barnett PG, Fiore L, Valley D, Thwin SS, Vertrees JE, Liang MH. Long-Acting Risperidone and Oral Antipsychotics in Unstable Schizophrenia. New England Journal Of Medicine 2011, 364: 842-851. PMID: 21366475, DOI: 10.1056/nejmoa1005987.
- Krystal J, Petrakis I, Limoncelli D, Nappi S, Trevisan L, Pittman B, D'Souza D. Erratum: Characterization of the Interactive Effects of Glycine and D-Cycloserine in Men: Further Evidence for Enhanced NMDA Receptor Function Associated with Human Alcohol Dependence. Neuropsychopharmacology 2011, 36: 911-911. PMCID: PMC3055722, DOI: 10.1038/npp.2011.2.
- Cosgrove KP, Esterlis I, Mason GF, Bois F, O’Malley S, Krystal JH. Neuroimaging insights into the role of cortical GABA systems and the influence of nicotine on the recovery from alcohol dependence. Neuropharmacology 2011, 60: 1318-1325. PMID: 21276806, PMCID: PMC3078950, DOI: 10.1016/j.neuropharm.2011.01.020.
- Rosenheck RA, Krystal JH, Lew R, Barnett PG, Thwin SS, Fiore L, Valley D, Huang GD, Neal C, Vertrees JE, Liang MH. Challenges in the design and conduct of controlled clinical effectiveness trials in schizophrenia. Clinical Trials 2011, 8: 196-204. PMID: 21270143, DOI: 10.1177/1740774510392931.
- Valentine GW, Mason GF, Gomez R, Fasula M, Watzl J, Pittman B, Krystal JH, Sanacora G. The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [1H]-MRS. Psychiatry Research 2011, 191: 122-127. PMID: 21232924, PMCID: PMC3061550, DOI: 10.1016/j.pscychresns.2010.10.009.
- Krystal J, Moghaddam B. Contributions of Glutamate and GABA Systems to the Neurobiology and Treatment of Schizophrenia. 2010, 433-461. DOI: 10.1002/9781444327298.ch21.
- Gueorguieva R, Wu R, Donovan D, Rounsaville BJ, Couper D, Krystal JH, O’Malley S. Baseline Trajectories of Drinking Moderate Acamprosate and Naltrexone Effects in the COMBINE Study. Alcohol Clinical And Experimental Research 2010, 35: 523-531. PMID: 21143249, PMCID: PMC3062945, DOI: 10.1111/j.1530-0277.2010.01369.x.
- Andrews MM, Meda SA, Thomas AD, Potenza MN, Krystal JH, Worhunsky P, Stevens MC, O'Malley S, Book GA, Reynolds B, Pearlson GD. Individuals Family History Positive for Alcoholism Show Functional Magnetic Resonance Imaging Differences in Reward Sensitivity That Are Related to Impulsivity Factors. Biological Psychiatry 2010, 69: 675-683. PMID: 21126735, PMCID: PMC3677031, DOI: 10.1016/j.biopsych.2010.09.049.
- Krystal JH, Petrakis IL, Limoncelli D, Nappi SK, Trevisan L, Pittman B, D'Souza DC. Characterization of the Interactive Effects of Glycine and D-Cycloserine in Men: Further Evidence for Enhanced NMDA Receptor Function Associated with Human Alcohol Dependence. Neuropsychopharmacology 2010, 36: 701-710. PMID: 21124304, PMCID: PMC3055693, DOI: 10.1038/npp.2010.203.
- Hallak JE, Dursun SM, Bosi DC, de Macedo LR, Machado-de-Sousa JP, Abrão J, Crippa JA, McGuire P, Krystal JH, Baker GB, Zuardi AW. The interplay of cannabinoid and NMDA glutamate receptor systems in humans: Preliminary evidence of interactive effects of cannabidiol and ketamine in healthy human subjects. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2010, 35: 198-202. PMID: 21062637, DOI: 10.1016/j.pnpbp.2010.11.002.
- N- methyl-D-aspartate Glutamate Receptor Antagonists and the Promise of Rapid-Acting AntidepressantsKrystal JH. N- methyl-D-aspartate Glutamate Receptor Antagonists and the Promise of Rapid-Acting Antidepressants. JAMA Psychiatry 2010, 67: 1110-1111. PMID: 21041611, DOI: 10.1001/archgenpsychiatry.2010.138.
- Corlett PR, Honey GD, Krystal JH, Fletcher PC. Glutamatergic Model Psychoses: Prediction Error, Learning, and Inference. Neuropsychopharmacology 2010, 36: 294-315. PMID: 20861831, PMCID: PMC3055519, DOI: 10.1038/npp.2010.163.
- Sewell RA, Perry EB, Karper LP, Bell MD, Lysaker P, Goulet JL, Brenner L, Erdos J, d'Souza DC, Seibyl JP, Krystal JH. Clinical significance of neurological soft signs in schizophrenia: Factor analysis of the Neurological Evaluation Scale. Schizophrenia Research 2010, 124: 1-12. PMID: 20855185, DOI: 10.1016/j.schres.2010.08.036.
- Nakic M, Krystal J, Bhagwagar Z. Neurotransmitter Systems in Bipolar Disorder. 2010, 210-227. DOI: 10.1002/9780470661277.ch16.
- Urban NB, Kegeles LS, Slifstein M, Xu X, Martinez D, Sakr E, Castillo F, Moadel T, O'Malley SS, Krystal JH, Abi-Dargham A. Sex Differences in Striatal Dopamine Release in Young Adults After Oral Alcohol Challenge: A Positron Emission Tomography Imaging Study With [11C]Raclopride. Biological Psychiatry 2010, 68: 689-696. PMID: 20678752, PMCID: PMC2949533, DOI: 10.1016/j.biopsych.2010.06.005.
- Krystal JH, Mathew SJ, D’Souza D, Garakani A, Gunduz-Bruce H, Charney DS. Potential Psychiatric Applications of Metabotropic Glutamate Receptor Agonists and Antagonists. CNS Drugs 2010, 24: 669-693. PMID: 20658799, DOI: 10.2165/11533230-000000000-00000.
- Corlett PR, Taylor JR, Wang X, Fletcher PC, Krystal JH. Toward a neurobiology of delusions. Progress In Neurobiology 2010, 92: 345-369. PMID: 20558235, PMCID: PMC3676875, DOI: 10.1016/j.pneurobio.2010.06.007.
- Sen S, Kranzler H, Krystal J, Speller H, Chan G, Gelernter J, Guille C. In Reply. JAMA Psychiatry 2010, 67: 568-569. DOI: 10.1001/archgenpsychiatry.2010.53.
- Cosgrove KP, Kloczynski T, Bois F, Pittman B, Tamagnan G, Seibyl JP, Krystal JH, Staley JK. Decreased Beta2*‐nicotinic acetylcholine receptor availability after chronic ethanol exposure in nonhuman primates. Synapse 2010, 64: 729-732. PMID: 20340174, PMCID: PMC2904861, DOI: 10.1002/syn.20795.
- Corlett PR, D'Souza DC, Krystal JH. Capgras Syndrome Induced by Ketamine in a Healthy Subject. Biological Psychiatry 2010, 68: e1-e2. PMID: 20385373, PMCID: PMC3721067, DOI: 10.1016/j.biopsych.2010.02.015.
- Sen S, Kranzler HR, Krystal JH, Speller H, Chan G, Gelernter J, Guille C. A Prospective Cohort Study Investigating Factors Associated With Depression During Medical Internship. JAMA Psychiatry 2010, 67: 557-565. PMID: 20368500, PMCID: PMC4036806, DOI: 10.1001/archgenpsychiatry.2010.41.
- Cavus I, Guglielmino R, Ford J, Roach B, Krystal J, Gueorguieva R, Mathalon D. IMPAIRED LONG-TERM POTENTIATION OF THE VISUAL EVOKED POTENTIAL IN SCHIZOPHRENIA. Schizophrenia Research 2010, 117: 244-245. DOI: 10.1016/j.schres.2010.02.373.
- Aikins DE, Anticevic A, Kiehl KA, Krystal JH. Sex-related differences in amygdala activity influences immediate memory. Neuroreport 2010, 21: 273-276. PMID: 20093991, DOI: 10.1097/wnr.0b013e328335b3f9.
- Hu J, Henry S, Gallezot JD, Ropchan J, Neumaier JF, Potenza MN, Sinha R, Krystal JH, Huang Y, Ding YS, Carson RE, Neumeister A. Serotonin 1B Receptor Imaging in Alcohol Dependence. Biological Psychiatry 2010, 67: 800-803. PMID: 20172504, PMCID: PMC3112181, DOI: 10.1016/j.biopsych.2009.12.028.
- Yun RJ, Krystal JH, Mathalon DH. Working Memory Overload: Fronto-Limbic Interactions and Effects on Subsequent Working Memory Function. Brain Imaging And Behavior 2010, 4: 96-108. PMID: 20503117, PMCID: PMC2854358, DOI: 10.1007/s11682-010-9089-9.
- Esterlis I, Cosgrove KP, Petrakis IL, McKee SA, Bois F, Krantzler E, Stiklus SM, Perry EB, Tamagnan GD, Seibyl JP, Krystal JH, Staley JK. SPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individuals. Drug And Alcohol Dependence 2010, 108: 146-150. PMID: 20074869, PMCID: PMC2871672, DOI: 10.1016/j.drugalcdep.2009.12.006.
- Gueorguieva R, Wu R, Donovan D, Rounsaville BJ, Couper D, Krystal JH, O’Malley S. Naltrexone and combined behavioral intervention effects on trajectories of drinking in the COMBINE study. Drug And Alcohol Dependence 2009, 107: 221-229. PMID: 19969427, PMCID: PMC2821955, DOI: 10.1016/j.drugalcdep.2009.10.017.
- Zuo L, Luo X, Kranzler HR, Lu L, Rosenheck RA, Cramer J, van Kammen DP, Erdos J, Charney DS, Krystal J, Gelernter J. Association study of DTNBP1 with schizophrenia in a US sample. Psychiatric Genetics 2009, 19: 292-304. PMID: 19862852, PMCID: PMC2771321, DOI: 10.1097/ypg.0b013e32832a50bc.
- Corlett PR, Simons JS, Pigott JS, Gardner JM, Murray GK, Krystal JH, Fletcher PC. Illusions and Delusions: Relating Experimentally-Induced False Memories to Anomalous Experiences and Ideas. Frontiers In Behavioral Neuroscience 2009, 3: 53. PMID: 19956402, PMCID: PMC2786301, DOI: 10.3389/neuro.08.053.2009.
- Krystal JH. The evolution of the psychiatry research journal. The Journal Of Clinical Psychiatry 2009, 70: 1601-2. PMID: 20031103, DOI: 10.4088/jcp.09com05629whi.
- Otto MW, Tolin DF, Simon NM, Pearlson GD, Basden S, Meunier SA, Hofmann SG, Eisenmenger K, Krystal JH, Pollack MH. Efficacy of D-Cycloserine for Enhancing Response to Cognitive-Behavior Therapy for Panic Disorder. Biological Psychiatry 2009, 67: 365-370. PMID: 19811776, DOI: 10.1016/j.biopsych.2009.07.036.
- Corlett PR, Krystal JH, Taylor JR, Fletcher PC. Why Do Delusions Persist? Frontiers In Human Neuroscience 2009, 3: 12. PMID: 19636384, PMCID: PMC2713737, DOI: 10.3389/neuro.09.012.2009.
- Landeros-Weisenberger A, Bloch MH, Kelmendi B, Wegner R, Nudel J, Dombrowski P, Pittenger C, Krystal JH, Goodman WK, Leckman JF, Coric V. Dimensional predictors of response to SRI pharmacotherapy in obsessive–compulsive disorder. Journal Of Affective Disorders 2009, 121: 175-179. PMID: 19577308, PMCID: PMC3974618, DOI: 10.1016/j.jad.2009.06.010.
- Driesen N, McCarthy G, Bhagwagar Z, Calhoun V, D'Souza D, Holub J, Morgan P, Krystal J. NMDA Receptor Antagonist Ketamine Produces Opposing Effects on Resting and Task-Related Brain Activation During Working Memory in Humans. NeuroImage 2009, 47: s145. DOI: 10.1016/s1053-8119(09)71458-2.
- Zuo L, Luo X, Krystal JH, Cramer J, Charney DS, Gelernter J. The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation. Pharmacogenetics And Genomics 2009, 19: 437-446. PMID: 19369910, PMCID: PMC2857717, DOI: 10.1097/fpc.0b013e32832b9cfc.
- Krystal JH, Tolin DF, Sanacora G, Castner SA, Williams GV, Aikins DE, Hoffman RE, D'Souza DC. Neuroplasticity as a target for the pharmacotherapy of anxiety disorders, mood disorders, and schizophrenia. Drug Discovery Today 2009, 14: 690-697. PMID: 19460458, PMCID: PMC2898127, DOI: 10.1016/j.drudis.2009.05.002.
- Cosgrove KP, Krantzler E, Frohlich EB, Stiklus S, Pittman B, Tamagnan GD, Baldwin RM, Bois F, Seibyl JP, Krystal JH, O'Malley SS, Staley JK. Dopamine and Serotonin Transporter Availability During Acute Alcohol Withdrawal: Effects of Comorbid Tobacco Smoking. Neuropsychopharmacology 2009, 34: 2218-2226. PMID: 19440191, PMCID: PMC4457331, DOI: 10.1038/npp.2009.49.
- Krystal JH, Neumeister A. Noradrenergic and serotonergic mechanisms in the neurobiology of posttraumatic stress disorder and resilience. Brain Research 2009, 1293: 13-23. PMID: 19332037, PMCID: PMC2761677, DOI: 10.1016/j.brainres.2009.03.044.
- Zuo L, Luo X, Listman JB, Kranzler HR, Wang S, Anton RF, Blumberg HP, Stein MB, Pearlson GD, Covault J, Charney DS, van Kammen DP, Price LH, Lappalainen J, Cramer J, Krystal JH, Gelernter J. Population admixture modulates risk for alcohol dependence. Human Genetics 2009, 125: 605-613. PMID: 19306106, PMCID: PMC2777998, DOI: 10.1007/s00439-009-0647-4.
- Krystal J. Biological Psychiatry: Real Progress. Biological Psychiatry 2009, 65: 3-4. DOI: 10.1016/j.biopsych.2008.08.026.
- Ranganathan M, Braley G, Pittman B, Cooper T, Perry E, Krystal J, D’Souza D. The effects of cannabinoids on serum cortisol and prolactin in humans. Psychopharmacology 2008, 203: 737. PMID: 19083209, PMCID: PMC2863108, DOI: 10.1007/s00213-008-1422-2.
- Southwick S, Friedman M, Krystal J. Does Psychoeducation Help Prevent Post Traumatic Psychological Stress Disorder? In Reply. Psychiatry 2008, 71: 303-307. PMID: 19152277, DOI: 10.1521/psyc.2008.71.4.303.
- Dickerson D, Pittman B, Ralevski E, Perrino A, Limoncelli D, Edgecombe J, Acampora G, Krystal J, Petrakis I. Ethanol-like effects of thiopental and ketamine in healthy humans. Journal Of Psychopharmacology 2008, 24: 203-211. PMID: 19028835, PMCID: PMC4484757, DOI: 10.1177/0269881108098612.
- Barch DM, Carter CS, Arnsten A, Buchanan RW, Cohen JD, Geyer M, Green MF, Krystal JH, Nuechterlein K, Robbins T, Silverstein S, Smith EE, Strauss M, Wykes T, Heinssen R. Selecting Paradigms From Cognitive Neuroscience for Translation into Use in Clinical Trials: Proceedings of the Third CNTRICS Meeting. Schizophrenia Bulletin 2008, 35: 109-114. PMID: 19023126, PMCID: PMC2643950, DOI: 10.1093/schbul/sbn163.
- Weder N, Yang BZ, Douglas-Palumberi H, Massey J, Krystal JH, Gelernter J, Kaufman J. MAOA Genotype, Maltreatment, and Aggressive Behavior: The Changing Impact of Genotype at Varying Levels of Trauma. Biological Psychiatry 2008, 65: 417-424. PMID: 18996506, PMCID: PMC3816252, DOI: 10.1016/j.biopsych.2008.09.013.
- Martinez D, Slifstein M, Gil R, Hwang DR, Huang Y, Perez A, Frankle WG, Laruelle M, Krystal J, Abi-Dargham A. Positron Emission Tomography Imaging of the Serotonin Transporter and 5-HT1A Receptor in Alcohol Dependence. Biological Psychiatry 2008, 65: 175-180. PMID: 18962444, PMCID: PMC2621104, DOI: 10.1016/j.biopsych.2008.08.034.
- Perepletchikova F, Krystal JH, Kaufman J. Practitioner Review: Adolescent alcohol use disorders: assessment and treatment issues. Journal Of Child Psychology And Psychiatry 2008, 49: 1131-1154. PMID: 19017028, PMCID: PMC4113213, DOI: 10.1111/j.1469-7610.2008.01934.x.
- Driesen NR, Leung HC, Calhoun VD, Constable RT, Gueorguieva R, Hoffman R, Skudlarski P, Goldman-Rakic PS, Krystal JH. Impairment of Working Memory Maintenance and Response in Schizophrenia: Functional Magnetic Resonance Imaging Evidence. Biological Psychiatry 2008, 64: 1026-1034. PMID: 18823880, PMCID: PMC2650279, DOI: 10.1016/j.biopsych.2008.07.029.
- Watson TD, Petrakis IL, Edgecombe J, Perrino A, Krystal JH, Mathalon DH. Modulation of the cortical processing of novel and target stimuli by drugs affecting glutamate and GABA neurotransmission. The International Journal Of Neuropsychopharmacology 2008, 12: 357-370. PMID: 18771605, PMCID: PMC2900256, DOI: 10.1017/s1461145708009334.
- Pittenger C, Coric V, Banasr M, Bloch M, Krystal JH, Sanacora G. Riluzole in the Treatment of Mood and Anxiety Disorders. CNS Drugs 2008, 22: 761-786. PMID: 18698875, DOI: 10.2165/00023210-200822090-00004.
- Krystal JH. Capitalizing on Extrasynaptic Glutamate Neurotransmission to Treat Antipsychotic-Resistant Symptoms in Schizophrenia. Biological Psychiatry 2008, 64: 358-360. PMID: 18694665, DOI: 10.1016/j.biopsych.2008.06.011.
- Cavus I, Pan JW, Hetherington HP, Abi‐Saab W, Zaveri HP, Vives KP, Krystal JH, Spencer SS, Spencer DD. Decreased hippocampal volume on MRI is associated with increased extracellular glutamate in epilepsy patients. Epilepsia 2008, 49: 1358-1366. PMID: 18410365, DOI: 10.1111/j.1528-1167.2008.01603.x.
- Carter CS, Barch DM, Buchanan RW, Bullmore E, Krystal JH, Cohen J, Geyer M, Green M, Nuechterlein KH, Robbins T, Silverstein S, Smith EE, Strauss M, Wykes T, Heinssen R. Identifying Cognitive Mechanisms Targeted for Treatment Development in Schizophrenia: An Overview of the First Meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia Initiative. Biological Psychiatry 2008, 64: 4-10. PMID: 18466880, PMCID: PMC2577821, DOI: 10.1016/j.biopsych.2008.03.020.
- Sanacora G, Zarate CA, Krystal JH, Manji HK. Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders. Nature Reviews Drug Discovery 2008, 7: 426-437. PMID: 18425072, PMCID: PMC2715836, DOI: 10.1038/nrd2462.
- Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, Berman KF, Blair J, Braff DL, Brown ES, Calabrese JR, Carlezon WA, Cook EH, Davidson RJ, Davis M, Desimone R, Drevets WC, Duman RS, Essock SM, Faraone SV, Freedman R, Friston KJ, Gelernter J, Geller B, Gill M, Gould E, Grace AA, Grillon C, Gueorguieva R, Hariri AR, Innis RB, Jones EG, Kleinman JE, Koob GF, Krystal AD, Leibenluft E, Levinson DF, Levitt PR, Lewis DA, Liberzon I, Lipska BK, Marder SR, Markou A, Mason GF, McDougle CJ, McEwen BS, McMahon FJ, Meaney MJ, Meltzer HY, Merikangas KR, Meyer-Lindenberg A, Mirnics K, Monteggia LM, Neumeister A, O’Brien C, Owen MJ, Pine DS, Rapoport JL, Rauch SL, Robbins TW, Rosenbaum JF, Rosenberg DR, Ross CA, Rush AJ, Sackeim HA, Sanacora G, Schatzberg AF, Shaham Y, Siever LJ, Sunderland T, Tecott LH, Thase ME, Todd RD, Weissman MM, Yehuda R, Yoshikawa T, Young EA, McCandless R. It Is Time to Take a Stand for Medical Research and Against Terrorism Targeting Medical Scientists. Biological Psychiatry 2008, 63: 725-727. PMID: 18371494, DOI: 10.1016/j.biopsych.2008.03.005.
- Norberg MM, Krystal JH, Tolin DF. A Meta-Analysis of D-Cycloserine and the Facilitation of Fear Extinction and Exposure Therapy. Biological Psychiatry 2008, 63: 1118-1126. PMID: 18313643, DOI: 10.1016/j.biopsych.2008.01.012.
- Jackowski AP, Douglas-Palumberi H, Jackowski M, Win L, Schultz RT, Staib LW, Krystal JH, Kaufman J. Corpus callosum in maltreated children with posttraumatic stress disorder: A diffusion tensor imaging study. Psychiatry Research 2008, 162: 256-261. PMID: 18296031, PMCID: PMC3771642, DOI: 10.1016/j.pscychresns.2007.08.006.
- Czermak C, Staley JK, Kasserman S, Bois F, Young T, Henry S, Tamagnan GD, Seibyl JP, Krystal JH, Neumeister A. β 2 Nicotinic acetylcholine receptor availability in post-traumatic stress disorder. The International Journal Of Neuropsychopharmacology 2008, 11: 419-424. PMID: 18190729, DOI: 10.1017/s1461145707008152.
- D'Souza DC, Ranganathan M, Braley G, Gueorguieva R, Zimolo Z, Cooper T, Perry E, Krystal J. Blunted Psychotomimetic and Amnestic Effects of Δ-9-Tetrahydrocannabinol in Frequent Users of Cannabis. Neuropsychopharmacology 2008, 33: 2505-2516. PMID: 18185500, PMCID: PMC3799954, DOI: 10.1038/sj.npp.1301643.
- Stone JM, Erlandsson K, Arstad E, Squassante L, Teneggi V, Bressan RA, Krystal JH, Ell PJ, Pilowsky LS. Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy—a [123I]CNS-1261 SPET study. Psychopharmacology 2008, 197: 401-408. PMID: 18176855, DOI: 10.1007/s00213-007-1047-x.
- Esterlis I, Bois F, Cosgrove K, Stiklus S, Perry E, Tamagnan G, Seibyl J, Krystal J, Staley J. Sex differences in nicotinic acetylcholine receptor availability in heavy alcohol drinkers. NeuroImage 2008, 41: t183. DOI: 10.1016/j.neuroimage.2008.04.150.
- Urban N, Martinez D, Zhou Y, Toda M, Xu X, Kegeles L, Slifstein M, Pearlson G, Krystal J, Abi-Dargham A. New probes for imaging dopamine transmission in at risk subjects for alcoholism. NeuroImage 2008, 41: t143. DOI: 10.1016/j.neuroimage.2008.04.111.
- Neumeister A, Czermak C, Henry S, Planeta-Wilson B, Huang H, Ding Y, Krystal J, Nabulsi N, Gallezot J, Carson R. Serotonin-1B receptor imaging in PTSD. NeuroImage 2008, 41: t163. DOI: 10.1016/j.neuroimage.2008.04.130.
- Krishnan-Sarin S, O'Malley S, Krystal JH. Treatment implications: using neuroscience to guide the development of new pharmacotherapies for alcoholism. Alcohol Research 2008, 31: 400-7. PMID: 23584013, PMCID: PMC3860468.
- Heninger G, Krystal J, Duman R, Bunney B, Bowers M, Aghajanian G. The Neuroscience Research Program at the Connecticut Mental Health Center. 2007, 77-95. DOI: 10.1002/9780470994580.ch4.
- Krystal J. Biological Psychiatry: Increasing Impact. Biological Psychiatry 2007, 62: 1203-1204. DOI: 10.1016/j.biopsych.2007.09.021.
- Goff DC, Keefe R, Citrome L, Davy K, Krystal JH, Large C, Thompson TR, Volavka J, Webster EL. Lamotrigine as Add-On Therapy in Schizophrenia. Journal Of Clinical Psychopharmacology 2007, 27: 582-589. PMID: 18004124, DOI: 10.1097/jcp.0b013e31815abf34.
- Trevisan L, Petrakis IL, Pittman B, Gueorguieva R, D’Souza D, Perry E, Limoncelli D, Krystal JH. Absence of Significant Interactive Effects of High‐Dose d‐Cycloserine and Ethanol in Healthy Human Subjects: Preliminary Insights Into Ethanol Actions at the GlycineB Site of NMDA Glutamate Receptors. Alcohol Clinical And Experimental Research 2007, 32: 36-42. PMID: 18028532, DOI: 10.1111/j.1530-0277.2007.00543.x.
- Krystal JH, Gueorguieva R, Cramer J, Collins J, Rosenheck R, Team T. Naltrexone Is Associated With Reduced Drinking by Alcohol Dependent Patients Receiving Antidepressants for Mood and Anxiety Symptoms: Results From VA Cooperative Study No. 425, “Naltrexone in the Treatment of Alcoholism”. Alcohol Clinical And Experimental Research 2007, 32: 85-91. PMID: 18070245, DOI: 10.1111/j.1530-0277.2007.00555.x.
- Martinez D, Kim JH, Krystal J, Abi-Dargham A. Imaging the Neurochemistry of Alcohol and Substance Abuse. Neuroimaging Clinics Of North America 2007, 17: 539-555. PMID: 17983969, DOI: 10.1016/j.nic.2007.07.004.
- Krystal JH. Neuroplasticity as a Target for the Pharmacotherapy of Psychiatric Disorders: New Opportunities for Synergy with Psychotherapy. Biological Psychiatry 2007, 62: 833-834. PMID: 17916459, DOI: 10.1016/j.biopsych.2007.08.017.
- Epperson CN, Amin Z, Naftolin F, Cappiello A, Czarkowski KA, Stiklus S, Anderson GM, Krystal JH. The resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findings. Journal Of Psychopharmacology 2007, 21: 414-420. PMID: 16891341, DOI: 10.1177/0269881106067330.
- Kaufman J, Massey J, Krystal J, Gelernter J. Reply. Biological Psychiatry 2007, 61: 1113-1115. DOI: 10.1016/j.biopsych.2006.07.004.
- Krystal JH. Ketamine and the potential role for rapid-acting antidepressant medications. Swiss Medical Weekly 2007, 137: 215-216. PMID: 17525875, DOI: 10.4414/smw.2007.11932.
- Pittenger C, Sanacora G, Krystal JH. The NMDA receptor as a therapeutic target in major depressive disorder. CNS & Neurological Disorders - Drug Targets 2007, 6: 101-15. PMID: 17430148, DOI: 10.2174/187152707780363267.
- Ford JM, Krystal JH, Mathalon DH. Neural Synchrony in Schizophrenia: From Networks to New Treatments. Schizophrenia Bulletin 2007, 33: 848-852. PMID: 17567628, PMCID: PMC2632315, DOI: 10.1093/schbul/sbm062.
- Krishnan-Sarin S, Krystal JH, Shi J, Pittman B, O’Malley S. Family History of Alcoholism Influences Naltrexone-Induced Reduction in Alcohol Drinking. Biological Psychiatry 2007, 62: 694-697. PMID: 17336941, DOI: 10.1016/j.biopsych.2006.11.018.
- Neumeister A, Charney D, Sanacora G, Krystal J. Neurobiology and Treatment of Depression. 2007 DOI: 10.1002/9780470101001.hcn018.
- Krupitsky EM, Neznanova O, Masalov D, Burakov AM, Didenko T, Romanova T, Tsoy M, Bespalov A, Slavina TY, Grinenko AA, Petrakis IL, Pittman B, Gueorguieva R, Zvartau EE, Krystal JH. Effect of Memantine on Cue-Induced Alcohol Craving in Recovering Alcohol-Dependent Patients. American Journal Of Psychiatry 2007, 164: 519-523. PMID: 17329479, DOI: 10.1176/ajp.2007.164.3.519.
- Luteal-Phase Accentuation of Acoustic Startle Response in Women with Premenstrual Dysphoric DisorderEpperson CN, Pittman B, Czarkowski KA, Stiklus S, Krystal JH, Grillon C. Luteal-Phase Accentuation of Acoustic Startle Response in Women with Premenstrual Dysphoric Disorder. Neuropsychopharmacology 2007, 32: 2190-2198. PMID: 17314917, PMCID: PMC2713599, DOI: 10.1038/sj.npp.1301351.
- Perry EB, Cramer JA, Cho HS, Petrakis IL, Karper LP, Genovese A, O’Donnell E, Krystal JH, D’Souza D. Psychiatric safety of ketamine in psychopharmacology research. Psychopharmacology 2007, 192: 253-260. PMID: 17458544, DOI: 10.1007/s00213-007-0706-2.
- Hoffman RE, Hampson M, Wu K, Anderson AW, Gore JC, Buchanan RJ, Constable RT, Hawkins KA, Sahay N, Krystal JH. Probing the Pathophysiology of Auditory/Verbal Hallucinations by Combining Functional Magnetic Resonance Imaging and Transcranial Magnetic Stimulation. Cerebral Cortex 2007, 17: 2733-2743. PMID: 17298962, PMCID: PMC2634833, DOI: 10.1093/cercor/bhl183.
- Krupitsky EM, Rudenko AA, Burakov AM, Slavina TY, Grinenko AA, Pittman B, Gueorguieva R, Petrakis IL, Zvartau EE, Krystal JH. Antiglutamatergic Strategies for Ethanol Detoxification: Comparison With Placebo and Diazepam. Alcohol Clinical And Experimental Research 2007, 31: 604-611. PMID: 17374039, DOI: 10.1111/j.1530-0277.2007.00344.x.
- Pittman B, Gueorguieva R, Krupitsky E, Rudenko AA, Flannery BA, Krystal JH. Multidimensionality of the Alcohol Withdrawal Symptom Checklist: A Factor Analysis of the Alcohol Withdrawal Symptom Checklist and CIWA‐Ar. Alcohol Clinical And Experimental Research 2007, 31: 612-618. PMID: 17374040, DOI: 10.1111/j.1530-0277.2007.00345.x.
- Gelernter J, Gueorguieva R, Kranzler HR, Zhang H, Cramer J, Rosenheck R, Krystal JH, Group T. Opioid Receptor Gene (OPRM1, OPRK1, and OPRD1) Variants and Response to Naltrexone Treatment for Alcohol Dependence: Results From the VA Cooperative Study. Alcohol Clinical And Experimental Research 2007, 31: 555-563. PMID: 17374034, DOI: 10.1111/j.1530-0277.2007.00339.x.
- McDougle CJ, Krystal JH. Pediatric psychopharmacology: mood, anxiety and disruptive behavior/pervasive developmental disorders. Psychopharmacology 2007, 191: 1-3. PMID: 17476481, DOI: 10.1007/s00213-007-0720-4.
- Gueorguieva R, Wu R, Pittman B, Cramer J, Rosenheck RA, O’Malley S, Krystal JH. New Insights into the Efficacy of Naltrexone Based on Trajectory-Based Reanalyses of Two Negative Clinical Trials. Biological Psychiatry 2007, 61: 1290-1295. PMID: 17224132, PMCID: PMC1952242, DOI: 10.1016/j.biopsych.2006.09.038.
- Sanacora G, Kendell SF, Levin Y, Simen AA, Fenton LR, Coric V, Krystal JH. Preliminary Evidence of Riluzole Efficacy in Antidepressant-Treated Patients with Residual Depressive Symptoms. Biological Psychiatry 2006, 61: 822-825. PMID: 17141740, PMCID: PMC2754299, DOI: 10.1016/j.biopsych.2006.08.037.
- Neumeister A, Carson R, Henry S, Planeta-Wilson B, Binneman B, Maguire RP, Luckenbaugh DA, D'Souza C, Krystal JH, Frost JJ. Cerebral Metabolic Effects of Intravenous Glycine in Healthy Human Subjects. Journal Of Clinical Psychopharmacology 2006, 26: 595-599. PMID: 17110816, DOI: 10.1097/01.jcp.0000245558.14284.aa.
- Sasso DA, Kalanithi PS, Trueblood KV, Pittenger C, Kelmendi B, Wayslink S, Malison RT, Krystal JH, Coric V. Beneficial Effects of the Glutamate-modulating Agent Riluzole on Disordered Eating and Pathological Skin-picking Behaviors. Journal Of Clinical Psychopharmacology 2006, 26: 685-687. PMID: 17110840, DOI: 10.1097/01.jcp.0000245567.29531.d6.
- Kaufman J, Yang BZ, Douglas-Palumberi H, Crouse-Artus M, Lipschitz D, Krystal JH, Gelernter J. Genetic and Environmental Predictors of Early Alcohol Use. Biological Psychiatry 2006, 61: 1228-1234. PMID: 17123474, DOI: 10.1016/j.biopsych.2006.06.039.
- Lappalainen J, Krupitsky E, Kranzler HR, Luo X, Remizov M, Pchelina S, Taraskina A, Zvartau E, Räsanen P, Makikyro T, Somberg LK, Krystal JH, Stein MB, Gelernter J. Mutation screen of the GAD2 gene and association study of alcoholism in three populations. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2006, 144B: 183-192. PMID: 17034009, DOI: 10.1002/ajmg.b.30377.
- Mason GF, Krystal JH. MR spectroscopy: its potential role for drug development for the treatment of psychiatric diseases. NMR In Biomedicine 2006, 19: 690-701. PMID: 16986118, DOI: 10.1002/nbm.1080.
- Krystal JH. Biological Psychiatry: A New Leadership Team. Biological Psychiatry 2006, 60: 794-795. PMID: 17045860, DOI: 10.1016/j.biopsych.2006.09.004.
- D'Souza DC, Gil RB, Madonick S, Perry EB, Forselius-Bielen K, Braley G, Donahue L, Tellioglu T, Zimolo Z, Gueorguieva R, Krystal JH. Enhanced Sensitivity to the Euphoric Effects of Alcohol in Schizophrenia. Neuropsychopharmacology 2006, 31: 2767-2775. PMID: 16985503, DOI: 10.1038/sj.npp.1301207.
- Krystal JH, Staley J, Mason G, Petrakis IL, Kaufman J, Harris RA, Gelernter J, Lappalainen J. γ-Aminobutyric Acid Type A Receptors and Alcoholism: Intoxication, Dependence, Vulnerability, and Treatment. JAMA Psychiatry 2006, 63: 957-968. PMID: 16952998, DOI: 10.1001/archpsyc.63.9.957.
- Krystal JH, D’Souza D, Gallinat J, Driesen N, Abi-Dargham A, Petrakis I, Heinz A, Pearlson G. The vulnerability to alcohol and substance abuse in individuals diagnosed with schizophrenia. Neurotoxicity Research 2006, 10: 235-252. PMID: 17197373, DOI: 10.1007/bf03033360.
- Rasmusson AM, Pinna G, Paliwal P, Weisman D, Gottschalk C, Charney D, Krystal J, Guidotti A. Decreased Cerebrospinal Fluid Allopregnanolone Levels in Women with Posttraumatic Stress Disorder. Biological Psychiatry 2006, 60: 704-713. PMID: 16934764, DOI: 10.1016/j.biopsych.2006.03.026.
- Morgan CJ, Perry EB, Cho HS, Krystal JH, D’Souza D. Greater vulnerability to the amnestic effects of ketamine in males. Psychopharmacology 2006, 187: 405-414. PMID: 16896964, DOI: 10.1007/s00213-006-0409-0.
- Amin Z, Mason GF, Cavus I, Krystal JH, Rothman DL, Epperson CN. The interaction of neuroactive steroids and GABA in the development of neuropsychiatric disorders in women. Pharmacology Biochemistry And Behavior 2006, 84: 635-643. PMID: 16860856, DOI: 10.1016/j.pbb.2006.06.007.
- Epperson CN, Gueorguieva R, Czarkowski KA, Stiklus S, Sellers E, Krystal JH, Rothman DL, Mason GF. Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study. Psychopharmacology 2006, 186: 425. PMID: 16724188, DOI: 10.1007/s00213-006-0313-7.
- Epperson CN, deWit H, Krystal JH. Advances in the translational neuroscience of neurosteroids. Psychopharmacology 2006, 186: 265. PMID: 16555064, DOI: 10.1007/s00213-006-0310-x.
- Pittenger C, Naungayan C, Kendell S, Coric V, Malison R, Krystal JH, Sanacora GS. Visual Hallucinations from the Addition of Riluzole to Memantine and Bupropion. Journal Of Clinical Psychopharmacology 2006, 26: 218-220. PMID: 16633160, DOI: 10.1097/01.jcp.0000203228.64117.9f.
- Kaufman J, Yang BZ, Douglas-Palumberi H, Grasso D, Lipschitz D, Houshyar S, Krystal JH, Gelernter J. Brain-Derived Neurotrophic Factor–5-HTTLPR Gene Interactions and Environmental Modifiers of Depression in Children. Biological Psychiatry 2006, 59: 673-680. PMID: 16458264, DOI: 10.1016/j.biopsych.2005.10.026.
- Blumberg HP, Krystal JH, Bansal R, Martin A, Dziura J, Durkin K, Martin L, Gerard E, Charney DS, Peterson BS. Age, Rapid-Cycling, and Pharmacotherapy Effects on Ventral Prefrontal Cortex in Bipolar Disorder: A Cross-Sectional Study. Biological Psychiatry 2006, 59: 611-618. PMID: 16414030, DOI: 10.1016/j.biopsych.2005.08.031.
- D'Souza D, Krystal J. Psychoactive Drugs. 2006 DOI: 10.1002/0470018860.s00599.
- Krystal JH, Madonick S, Perry E, Gueorguieva R, Brush L, Wray Y, Belger A, D'Souza DC. Potentiation of Low Dose Ketamine Effects by Naltrexone: Potential Implications for the Pharmacotherapy of Alcoholism. Neuropsychopharmacology 2006, 31: 1793-1800. PMID: 16395307, DOI: 10.1038/sj.npp.1300994.
- Staley J, Tellioglu T, Bois F, Palazzo C, McGuire-Schwartz N, Cosgrove K, van Dyck C, Tamagnan G, Seibyl J, Krystal J, D'Souza D. [I-123] 5-IA-85380 SPECT imaging of beta2-nicotinic acetylcholine receptors in recently abstinent mentally healthy and schizophrenic smokers. NeuroImage 2006, 31: t154. DOI: 10.1016/j.neuroimage.2006.04.137.
- Pittenger C, Krystal JH, Coric V. Glutamate-modulating drugs as novel pharmacotherapeutic agents in the treatment of obsessive-compulsive disorder. Neurotherapeutics 2006, 3: 69-81. PMID: 16490414, PMCID: PMC3593363, DOI: 10.1016/j.nurx.2005.12.006.
- Lafleur DL, Pittenger C, Kelmendi B, Gardner T, Wasylink S, Malison RT, Sanacora G, Krystal JH, Coric V. N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder. Psychopharmacology 2005, 184: 254-256. PMID: 16374600, DOI: 10.1007/s00213-005-0246-6.
- Blumberg HP, Fredericks C, Wang F, Kalmar JH, Spencer L, Papademetris X, Pittman B, Martin A, Peterson BS, Fulbright RK, Krystal JH. Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder. Bipolar Disorders 2005, 7: 570-576. PMID: 16403182, PMCID: PMC2291299, DOI: 10.1111/j.1399-5618.2005.00264.x.
- Pittenger C, Krystal JH, Coric V. Initial evidence of the beneficial effects of glutamate-modulating agents in the treatment of self-injurious behavior associated with borderline personality disorder. The Journal Of Clinical Psychiatry 2005, 66: 1492-3. PMID: 16420092, DOI: 10.4088/jcp.v66n1121d.
- Keller MB, Krystal JH, Hen R, Neumeister A, Simon NM. Untangling depression and anxiety: clinical challenges. The Journal Of Clinical Psychiatry 2005, 66: 1477-84. PMID: 16420087, DOI: 10.4088/jcp.v66n1119.
- Mason GF, Petrakis IL, de Graaf RA, Gueorguieva R, Guidone E, Coric V, Epperson CN, Rothman DL, Krystal JH. Cortical Gamma-Aminobutyric Acid Levels and the Recovery from Ethanol Dependence: Preliminary Evidence of Modification by Cigarette Smoking. Biological Psychiatry 2005, 59: 85-93. PMID: 16289397, DOI: 10.1016/j.biopsych.2005.06.009.
- Pittenger C, Kelmendi B, Bloch M, Krystal JH, Coric V. Clinical treatment of obsessive compulsive disorder. Innov Clin Neurosci 2005, 2: 34-43. PMID: 21120095, PMCID: PMC2993523.
- Blumberg HP, Donegan NH, Sanislow CA, Collins S, Lacadie C, Skudlarski P, Gueorguieva R, Fulbright RK, McGlashan TH, Gore JC, Krystal JH. Preliminary evidence for medication effects on functional abnormalities in the amygdala and anterior cingulate in bipolar disorder. Psychopharmacology 2005, 183: 308-313. PMID: 16249909, DOI: 10.1007/s00213-005-0156-7.
- Pilowsky LS, Bressan RA, Stone JM, Erlandsson K, Mulligan RS, Krystal JH, Ell PJ. First in vivo evidence of an NMDA receptor deficit in medication-free schizophrenic patients. Molecular Psychiatry 2005, 11: 118-119. PMID: 16189506, DOI: 10.1038/sj.mp.4001751.
- Cho RY, Ford JM, Krystal JH, Laruelle M, Cuthbert B, Carter CS. Functional Neuroimaging and Electrophysiology Biomarkers for Clinical Trials for Cognition in Schizophrenia. Schizophrenia Bulletin 2005, 31: 865-869. PMID: 16166611, DOI: 10.1093/schbul/sbi050.
- Li CS, Krystal JH, Mathalon DH. Fore-period effect and stop-signal reaction time. Experimental Brain Research 2005, 167: 305-309. PMID: 16160823, DOI: 10.1007/s00221-005-0110-2.
- D’Souza D, Gil RB, Zuzarte E, MacDougall LM, Donahue L, Ebersole JS, Boutros NN, Cooper T, Seibyl J, Krystal JH. γ-Aminobutyric Acid–Serotonin Interactions in Healthy Men: Implications for Network Models of Psychosis and Dissociation. Biological Psychiatry 2005, 59: 128-137. PMID: 16140281, DOI: 10.1016/j.biopsych.2005.06.020.
- Sanacora G, Fenton LR, Fasula MK, Rothman DL, Levin Y, Krystal JH, Mason GF. Cortical γ-Aminobutyric Acid Concentrations in Depressed Patients Receiving Cognitive Behavioral Therapy. Biological Psychiatry 2005, 59: 284-286. PMID: 16139814, DOI: 10.1016/j.biopsych.2005.07.015.
- Coric V, Taskiran S, Pittenger C, Wasylink S, Mathalon DH, Valentine G, Saksa J, Wu YT, Gueorguieva R, Sanacora G, Malison RT, Krystal JH. Riluzole Augmentation in Treatment-Resistant Obsessive–Compulsive Disorder: An Open-Label Trial. Biological Psychiatry 2005, 58: 424-428. PMID: 15993857, DOI: 10.1016/j.biopsych.2005.04.043.
- Krystal JH, Perry EB, Gueorguieva R, Belger A, Madonick SH, Abi-Dargham A, Cooper TB, MacDougall L, Abi-Saab W, D’Souza D. Comparative and Interactive Human Psychopharmacologic Effects of Ketamine and Amphetamine: Implications for Glutamatergic and Dopaminergic Model Psychoses and Cognitive Function. JAMA Psychiatry 2005, 62: 985-995. PMID: 16143730, DOI: 10.1001/archpsyc.62.9.985.
- Staley JK, Gottschalk C, Petrakis IL, Gueorguieva R, O’Malley S, Baldwin R, Jatlow P, Verhoeff NP, Perry E, Weinzimmer D, Frohlich E, Ruff E, van Dyck CH, Seibyl JP, Innis RB, Krystal JH. Cortical γ-Aminobutyric Acid Type A–Benzodiazepine Receptors in Recovery From Alcohol Dependence: Relationship to Features of Alcohol Dependence and Cigarette Smoking. JAMA Psychiatry 2005, 62: 877-888. PMID: 16061765, DOI: 10.1001/archpsyc.62.8.877.
- Martinez D, Gil R, Slifstein M, Hwang DR, Huang Y, Perez A, Kegeles L, Talbot P, Evans S, Krystal J, Laruelle M, Abi-Dargham A. Alcohol Dependence Is Associated with Blunted Dopamine Transmission in the Ventral Striatum. Biological Psychiatry 2005, 58: 779-786. PMID: 16018986, DOI: 10.1016/j.biopsych.2005.04.044.
- Hoffman RE, Gueorguieva R, Hawkins KA, Varanko M, Boutros NN, Wu YT, Carroll K, Krystal JH. Temporoparietal Transcranial Magnetic Stimulation for Auditory Hallucinations: Safety, Efficacy and Moderators in a Fifty Patient Sample. Biological Psychiatry 2005, 58: 97-104. PMID: 15936729, DOI: 10.1016/j.biopsych.2005.03.041.
- Bressan RA, Erlandsson K, Stone JM, Mulligan RS, Krystal JH, Ell PJ, Pilowsky LS. Impact of Schizophrenia and Chronic Antipsychotic Treatment on [123I]CNS-1261 Binding to N-Methyl-D-Aspartate Receptors In Vivo. Biological Psychiatry 2005, 58: 41-46. PMID: 15992521, DOI: 10.1016/j.biopsych.2005.03.016.
- Kiehl KA, Stevens MC, Celone K, Kurtz M, Krystal JH. Abnormal hemodynamics in schizophrenia during an auditory oddball task. Biological Psychiatry 2005, 57: 1029-1040. PMID: 15860344, PMCID: PMC2771438, DOI: 10.1016/j.biopsych.2005.01.035.
- Lappalainen J, Krupitsky E, Remizov M, Pchelina S, Taraskina A, Zvartau E, Somberg LK, Covault J, Kranzler HR, Krystal JH, Gelernter J. Association Between Alcoholism and γ‐Amino Butyric Acid α2 Receptor Subtype in a Russian Population. Alcohol Clinical And Experimental Research 2005, 29: 493-498. PMID: 15834213, DOI: 10.1097/01.alc.0000158938.97464.90.
- D’Souza D, Abi-Saab WM, Madonick S, Forselius-Bielen K, Doersch A, Braley G, Gueorguieva R, Cooper TB, Krystal JH. Delta-9-tetrahydrocannabinol effects in schizophrenia: Implications for cognition, psychosis, and addiction. Biological Psychiatry 2005, 57: 594-608. PMID: 15780846, DOI: 10.1016/j.biopsych.2004.12.006.
- Kendell SF, Krystal JH, Sanacora G. GABA and glutamate systems as therapeutic targets in depression and mood disorders. Expert Opinion On Therapeutic Targets 2005, 9: 153-168. PMID: 15757488, DOI: 10.1517/14728222.9.1.153.
- Cho HS, D’Souza D, Gueorguieva R, Perry EB, Madonick S, Karper LP, Abi-Dargham A, Belger A, Abi-Saab W, Lipschitz D, Bennet A, Seibyl JP, Krystal JH. Absence of behavioral sensitization in healthy human subjects following repeated exposure to ketamine. Psychopharmacology 2005, 179: 136-143. PMID: 15682309, DOI: 10.1007/s00213-004-2066-5.
- Cavus I, Kasoff WS, Cassaday MP, Jacob R, Gueorguieva R, Sherwin RS, Krystal JH, Spencer DD, Abi‐Saab W. Extracellular metabolites in the cortex and hippocampus of epileptic patients. Annals Of Neurology 2005, 57: 226-235. PMID: 15668975, DOI: 10.1002/ana.20380.
- Perry E, Gil R, Miles D, Brenner L, Macdougall L, Johnson R, Degen K, Gueorguieva R, Petrakis I, Krystal J, D'Souza D. Mazindol Augmentation of Antipsychotic Treatment for Schizophrenic Patients with Comorbid Cocaine Abuse or Dependence. Journal Of Dual Diagnosis 2005, 1: 37-47. DOI: 10.1300/j374v01n01_04.
- Tsoy M, Krupitsky E, Neznanova O, Burakov A, Didenko T, Masalov D, Romanova T, Bespalov A, Zvartau E, Krystal J. P.3.10 Ethanol-like effects of N-methyl-d-aspartatereceptors antagonist memantine, and its ability to prevent cue induced alcohol craving. European Neuropsychopharmacology 2005, 15: s59-s60. DOI: 10.1016/s0924-977x(05)80177-4.
- Mason G, Bendszus M, Meyerhoff D, Hetherington H, Schweinsburg B, Ross B, Taylor M, Krystal J. Magnetic Resonance Spectroscopic Studies of Alcoholism: From Heavy Drinking to Alcohol Dependence and Back Again. Alcohol Clinical And Experimental Research 2005, 29: 150-158. PMID: 15895489, DOI: 10.1097/01.alc.0000150010.72739.58.
- Daurignac E, Toga A, Jones D, Aronen H, Hommer D, Jernigan T, Krystal J, Mathalon D. Applications of Morphometric and Diffusion Tensor Magnetic Resonance Imaging to the Study of Brain Abnormalities in the Alcoholism Spectrum. Alcohol Clinical And Experimental Research 2005, 29: 159-166. PMID: 15895490, DOI: 10.1097/01.alc.0000150891.72900.62.
- Epperson CN, O’Malley S, Czarkowski KA, Gueorguieva R, Jatlow P, Sanacora G, Rothman DL, Krystal JH, Mason GF. Sex, GABA, and nicotine: The impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopy. Biological Psychiatry 2005, 57: 44-48. PMID: 15607299, PMCID: PMC4097033, DOI: 10.1016/j.biopsych.2004.09.021.
- Jacobsen LK, Krystal JH, Mencl WE, Westerveld M, Frost SJ, Pugh KR. Effects of smoking and smoking abstinence on cognition in adolescent tobacco smokers. Biological Psychiatry 2005, 57: 56-66. PMID: 15607301, DOI: 10.1016/j.biopsych.2004.10.022.
- Hoffman R, Mathalon D, Ford J, Krystal J. Cortico – (thalamo) – cortical interactions, gamma resonance, and auditory hallucinations in schizophrenia. Behavioral And Brain Sciences 2004, 27: 797-798. DOI: 10.1017/s0140525x04320182.
- Goddard AW, Mason GF, Appel M, Rothman DL, Gueorguieva R, Behar KL, Krystal JH. Impaired GABA Neuronal Response to Acute Benzodiazepine Administration in Panic Disorder. American Journal Of Psychiatry 2004, 161: 2186-2193. PMID: 15569888, DOI: 10.1176/appi.ajp.161.12.2186.
- Kaufman J, Yang BZ, Douglas-Palumberi H, Houshyar S, Lipschitz D, Krystal JH, Gelernter J. Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 17316-17321. PMID: 15563601, PMCID: PMC534414, DOI: 10.1073/pnas.0404376101.
- Sanacora G, Kendell SF, Fenton L, Coric V, Krystal JH. Riluzole Augmentation for Treatment-Resistant Depression. American Journal Of Psychiatry 2004, 161: 2132-2132. PMID: 15514421, DOI: 10.1176/appi.ajp.161.11.2132.
- Petrakis IL, Limoncelli D, Gueorguieva R, Jatlow P, Boutros NN, Trevisan L, Gelernter J, Krystal JH. Altered NMDA Glutamate Receptor Antagonist Response in Individuals With a Family Vulnerability to Alcoholism. American Journal Of Psychiatry 2004, 161: 1776-1782. PMID: 15465973, DOI: 10.1176/ajp.161.10.1776.
- Krystal JH, Abi-Saab W, Perry E, D’Souza D, Liu N, Gueorguieva R, McDougall L, Hunsberger T, Belger A, Levine L, Breier A. Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects. Psychopharmacology 2004, 179: 303-309. PMID: 15309376, DOI: 10.1007/s00213-004-1982-8.
- Krishnan-Sarin S, Shih J, Krystal J, O’Malley S. HPA AXIS RESPONSIVITY AND ALCOHOL DRINKING: INTERACTIVE EFFECTS OF FAMILY HISTORY OF ALCOHOLISM AND NALTREXONE TREATMENT. Alcohol Clinical And Experimental Research 2004, 28: 73a. DOI: 10.1097/00000374-200408002-00397.
- Krupitsky E, Rudenko A, Burakov A, Zvartau E, Slavina T, Grinenko A, Krystal J. ANTI-GLUTAMATE TREATMENTS FOR ALCOHOL DETOXIFICATION: A DOUBLE-BLIND PLACEBO-CONTROLLED PILOT STUDY OF LAMOTRIGINE, MEMANTINE, AND TOPIRAMATE. Alcohol Clinical And Experimental Research 2004, 28: 50a. DOI: 10.1097/00000374-200408002-00258.
- Malhotra A, Krystal J. Molecular genetics and psychopharmacology. Psychopharmacology 2004, 174: 439-440. DOI: 10.1007/s00213-004-1947-y.
- Sanacora G, Gueorguieva R, Epperson CN, Wu YT, Appel M, Rothman DL, Krystal JH, Mason GF. Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression. JAMA Psychiatry 2004, 61: 705-713. PMID: 15237082, DOI: 10.1001/archpsyc.61.7.705.
- Petrakis I, O’Malley S, Rounsaville B, Poling J, McHugh-Strong C, Krystal J, VA Naltrexone Study Collaboration Group. Naltrexone augmentation of neuroleptic treatment in alcohol abusing patients with schizophrenia. Psychopharmacology 2004, 174: 300-300. DOI: 10.1007/s00213-004-1881-z.
- D'Souza DC, Perry E, MacDougall L, Ammerman Y, Cooper T, Wu YT, Braley G, Gueorguieva R, Krystal JH. The Psychotomimetic Effects of Intravenous Delta-9-Tetrahydrocannabinol in Healthy Individuals: Implications for Psychosis. Neuropsychopharmacology 2004, 29: 1558-1572. PMID: 15173844, DOI: 10.1038/sj.npp.1300496.
- BLUMBERG HP, KAUFMAN J, MARTIN A, CHARNEY DS, KRYSTAL JH, PETERSON BS. Significance of Adolescent Neurodevelopment for the Neural Circuitry of Bipolar Disorder. Annals Of The New York Academy Of Sciences 2004, 1021: 376-383. PMID: 15251913, DOI: 10.1196/annals.1308.048.
- D'souza D, Cho H, Perry E, Krystal J. Cannabinoid ‘model’ psychosis, dopamine–cannabinoid interactions and implications for schizophrenia. 2004, 142-165. DOI: 10.1017/cbo9780511543630.012.
- Cho H, Krystal J, D’Souza D. Blood dyscrasias. 2004, 221-238. DOI: 10.1093/med/9780198527480.003.0012.
- Jacobsen LK, D'Souza DC, Mencl WE, Pugh KR, Skudlarski P, Krystal JH. Nicotine effects on brain function and functional connectivity in schizophrenia. Biological Psychiatry 2004, 55: 850-858. PMID: 15050867, DOI: 10.1016/j.biopsych.2003.12.023.
- Gueorguieva R, Krystal JH. Move Over ANOVA: Progress in Analyzing Repeated-Measures Data andIts Reflection in Papers Published in the Archives of General Psychiatry. JAMA Psychiatry 2004, 61: 310-317. PMID: 14993119, DOI: 10.1001/archpsyc.61.3.310.
- Lappalainen J, Kranzler HR, Petrakis I, Somberg LK, Page G, Krystal JH, Gelernter J. Confirmation and fine mapping of the chromosome 1 alcohol dependence risk locus. Molecular Psychiatry 2004, 9: 312-319. PMID: 15094791, DOI: 10.1038/sj.mp.4001429.
- Family Psychopathology and Magnitude of Reductions in Occipital Cortex GABA Levels in Panic DisorderGoddard AW, Mason GF, Rothman DL, Behar KL, Petroff O, Krystal JH. Family Psychopathology and Magnitude of Reductions in Occipital Cortex GABA Levels in Panic Disorder. Neuropsychopharmacology 2004, 29: 639-640. PMID: 14973435, DOI: 10.1038/sj.npp.1300374.
- Blumberg HP, Kaufman J, Martin A, Whiteman R, Zhang JH, Gore JC, Charney DS, Krystal JH, Peterson BS. Amygdala and Hippocampal Volumes in Adolescents and Adults With Bipolar Disorder. JAMA Psychiatry 2003, 60: 1201-1208. PMID: 14662552, DOI: 10.1001/archpsyc.60.12.1201.
- Heinz A, Schäfer M, Higley J, Krystal J, Goldman D. Neurobiological Correlates of the Disposition and Maintenance of Alcoholism. Pharmacopsychiatry 2003, 36: 255-258. PMID: 14677088, DOI: 10.1055/s-2003-45139.
- Jacobsen LK, Mencl WE, Pugh KR, Skudlarski P, Krystal JH. Preliminary evidence of hippocampal dysfunction in adolescent MDMA (“ecstasy”) users: possible relationship to neurotoxic effects. Psychopharmacology 2003, 173: 383-390. PMID: 14647960, DOI: 10.1007/s00213-003-1679-4.
- Petrakis IL, O’Malley S, Rounsaville B, Poling J, McHugh-Strong C, Krystal JH, VA Naltrexone Study Collaboration Group. Naltrexone augmentation of neuroleptic treatment in alcohol abusing patients with schizophrenia. Psychopharmacology 2003, 172: 291-297. PMID: 14634716, DOI: 10.1007/s00213-003-1658-9.
- Roberts LW, Krystal J. A time of promise, a time of promises: ethical issues in advancing psychopharmacological research. Psychopharmacology 2003, 171: 1-5. PMID: 14615879, DOI: 10.1007/s00213-003-1704-7.
- Qin J, Mitchell K, Johnson M, Krystal J, Southwick S, Rasmusson A, Allen E. Reactions to and memories for the September 11, 2001 terrorist attacks in adults with posttraumatic stress disorder. Applied Cognitive Psychology 2003, 17: 1081-1097. DOI: 10.1002/acp.987.
- SANACORA G, ROTHMAN DL, MASON G, KRYSTAL JH. Clinical Studies Implementing Glutamate Neurotransmission in Mood Disorders. Annals Of The New York Academy Of Sciences 2003, 1003: 292-308. PMID: 14684453, DOI: 10.1196/annals.1300.018.
- KRYSTAL JH, PETRAKIS IL, KRUPITSKY E, SCHÜTZ C, TREVISAN L, D'SOUZA DC. NMDA Receptor Antagonism and the Ethanol Intoxication Signal. Annals Of The New York Academy Of Sciences 2003, 1003: 176-184. PMID: 14684445, DOI: 10.1196/annals.1300.010.
- Krystal J, D'Souza D, Mathalon D, Belger A, Perry E. S.01.03 Therapeutic implications of the NMDA receptor antagonist model psychosis. European Neuropsychopharmacology 2003, 13: s96. DOI: 10.1016/s0924-977x(03)91600-2.
- Rasmusson A, Guidotti A, Charney D, Vojvoda D, Lipschitz D, Weisman D, Krystal J. S.20.01 Adrenal & CSF neurosteroids as mediators of HPA axis upregulation and symptom production in premenopausal women with PTSD. European Neuropsychopharmacology 2003, 13: s151-s152. DOI: 10.1016/s0924-977x(03)91680-4.
- Krystal JH, D'Souza DC, Mathalon D, Perry E, Belger A, Hoffman R. NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development. Psychopharmacology 2003, 169: 215-233. PMID: 12955285, DOI: 10.1007/s00213-003-1582-z.
- Cramer J, Rosenheck R, Kirk G, Krol W, Krystal J, 425 F. Medication Compliance Feedback and Monitoring in a Clinical Trial: Predictors and Outcomes. Value In Health 2003, 6: 566-573. PMID: 14627063, DOI: 10.1046/j.1524-4733.2003.65269.x.
- Harvey PD, Geyer MA, Robbins TW, Krystal JH. Cognition in schizophrenia: from basic science to clinical treatment. Psychopharmacology 2003, 169: 213-214. PMID: 12955286, DOI: 10.1007/s00213-003-1581-0.
- Lappalainen J, Sanacora G, Kranzler HR, Malison R, Hibbard ES, Price LH, Krystal J, Gelernter J. Mutation screen of the glutamate decarboxylase‐67 gene and haplotype association to unipolar depression. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2003, 124B: 81-86. PMID: 14681921, DOI: 10.1002/ajmg.b.20055.
- Mathalon DH, Rapoport JL, Davis KL, Krystal JH. Neurotoxicity, Neuroplasticity, and Magnetic Resonance Imaging Morphometry. JAMA Psychiatry 2003, 60: 846-848. PMID: 12912768, DOI: 10.1001/archpsyc.60.8.846.
- Blumberg HP, Martin A, Kaufman J, Leung HC, Skudlarski P, Lacadie C, Fulbright RK, Gore JC, Charney DS, Krystal JH, Peterson BS. Frontostriatal Abnormalities in Adolescents With Bipolar Disorder: Preliminary Observations From Functional MRI. American Journal Of Psychiatry 2003, 160: 1345-1347. PMID: 12832254, DOI: 10.1176/appi.ajp.160.7.1345.
- Krystal JH, Petrakis IL, Mason G, Trevisan L, D'Souza DC. N-methyl-d-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability. Pharmacology & Therapeutics 2003, 99: 79-94. PMID: 12804700, DOI: 10.1016/s0163-7258(03)00054-8.
- Krystal JH, Petrakis IL, Limoncelli D, Webb E, Gueorgueva R, D'Souza DC, Boutros NN, Trevisan L, Charney DS. Altered NMDA Glutamate Receptor Antagonist Response in Recovering Ethanol-Dependent Patients. Neuropsychopharmacology 2003, 28: 2020-2028. PMID: 12888778, DOI: 10.1038/sj.npp.1300252.
- Blumberg HP, Leung HC, Skudlarski P, Lacadie CM, Fredericks CA, Harris BC, Charney DS, Gore JC, Krystal JH, Peterson BS. A Functional Magnetic Resonance Imaging Study of Bipolar Disorder: State- and Trait-Related Dysfunction in Ventral Prefrontal Cortices. JAMA Psychiatry 2003, 60: 601-609. PMID: 12796223, DOI: 10.1001/archpsyc.60.6.601.
- Morgan CA, Krystal JH, Southwick SM. Toward early pharmacological posttraumatic stress intervention. Biological Psychiatry 2003, 53: 834-843. PMID: 12725976, DOI: 10.1016/s0006-3223(03)00116-1.
- Coric V, Milanovic S, Wasylink S, Patel P, Malison R, Krystal JH. Beneficial effects of the antiglutamatergic agent riluzole in a patient diagnosed with obsessive-compulsive disorder and major depressive disorder. Psychopharmacology 2003, 167: 219-220. PMID: 12658528, DOI: 10.1007/s00213-003-1396-z.
- D'Souza D, Perry E, Riccardi P, Abi-Saab W, Krystal J. Cannabinoids and psychosis: Pharmacological studies with IV delta-9-THC in humans. Schizophrenia Research 2003, 60: 310. DOI: 10.1016/s0920-9964(03)80247-5.
- Jacobsen L, Mencl W, D'Souza D, Pugh K, Skudlarski P, Abi-Saab W, Krystal J. Impact of nicotine on brain function in smokers with schizophrenia. Schizophrenia Research 2003, 60: 223-224. DOI: 10.1016/s0920-9964(03)81196-9.
- Sanacora G, Mason GF, Rothman DL, Hyder F, Ciarcia JJ, Ostroff RB, Berman RM, Krystal JH. Increased Cortical GABA Concentrations in Depressed Patients Receiving ECT. American Journal Of Psychiatry 2003, 160: 577-579. PMID: 12611844, DOI: 10.1176/appi.ajp.160.3.577.
- Moghaddam B, Krystal J. The Neurochemistry of Schizophrenia. 2003, 349-364. DOI: 10.1002/9780470987353.ch19.
- Hoffman RE, Hawkins KA, Gueorguieva R, Boutros NN, Rachid F, Carroll K, Krystal JH. Transcranial Magnetic Stimulation of Left Temporoparietal Cortex and Medication-Resistant Auditory Hallucinations. JAMA Psychiatry 2003, 60: 49-56. PMID: 12511172, DOI: 10.1001/archpsyc.60.1.49.
- Sierra M, Phillips ML, Ivin G, Krystal J, David AS. A placebo-controlled, cross-over trial of lamotrigine in depersonalization disorder. Journal Of Psychopharmacology 2003, 17: 103-105. PMID: 12680746, DOI: 10.1177/0269881103017001712.
- Kane JM, Krystal J, Correll CU. Treatment Models and Designs for Intervention Research During the Psychotic Prodrome. Schizophrenia Bulletin 2003, 29: 747-756. PMID: 14989412, DOI: 10.1093/oxfordjournals.schbul.a007044.
- Blumberg HP, Charney DS, Krystal JH. Frontotemporal neural systems in bipolar disorder. Seminars In Clinical Neuropsychiatry 2002, 7: 243-54. PMID: 12382207, DOI: 10.1053/scnp.2002.35220.
- Epperson CN, Haga K, Mason GF, Sellers E, Gueorguieva R, Zhang W, Weiss E, Rothman DL, Krystal JH. Cortical γ-Aminobutyric Acid Levels Across the Menstrual Cycle in Healthy Women and Those With Premenstrual Dysphoric Disorder: A Proton Magnetic Resonance Spectroscopy Study. JAMA Psychiatry 2002, 59: 851-858. PMID: 12215085, DOI: 10.1001/archpsyc.59.9.851.
- Lappalainen J, Kranzler HR, Malison R, Price LH, Van Dyck C, Rosenheck RA, Cramer J, Southwick S, Charney D, Krystal J, Gelernter J. A Functional Neuropeptide Y Leu7Pro Polymorphism Associated With Alcohol Dependence in a Large Population Sample From the United States. JAMA Psychiatry 2002, 59: 825-831. PMID: 12215082, DOI: 10.1001/archpsyc.59.9.825.
- Krystal J, Petrakis I, D'Souza D, Mason G, Trevisan L. Alcohol and Glutamate Neurotransmission in Humans: Implications for Reward, Dependence, and Treatment. 2002, 0: 389-398. DOI: 10.1385/1-59259-306-2:389.
- Petrakis I, Buonopane A, O???Malley S, Cermik O, Trevisan L, Boutros N, Limoncelli D, Krystal J. The Effect of Tryptophan Depletion on Alcohol Self-Administration in Non-Treatment-Seeking Alcoholic Individuals. Alcohol Clinical And Experimental Research 2002, 26: 969-975. DOI: 10.1097/00000374-200207000-00005.
- Petrakis IL, Buonopane A, O'Malley S, Cermik O, Trevisan L, Boutros NN, Limoncelli D, Krystal JH. The Effect of Tryptophan Depletion on Alcohol Self‐Administration in Non‐Treatment‐Seeking Alcoholic Individuals. Alcohol Clinical And Experimental Research 2002, 26: 969-975. PMID: 12170105, DOI: 10.1111/j.1530-0277.2002.tb02629.x.
- Krystal JH, Anand A, Moghaddam B. Effects of NMDA receptor antagonists: implications for the pathophysiology of schizophrenia. JAMA Psychiatry 2002, 59: 663-4. PMID: 12090822, DOI: 10.1001/archpsyc.59.7.663.
- Cramer J, Rosenheck R, Krystal J, Kirk G, Krol W. PMH1 USEFULNESS OF ELECTRONIC COMPLIANCE DATA IN AN EFFECTIVENESS TRIAL. Value In Health 2002, 5: 226. DOI: 10.1016/s1098-3015(10)61067-4.
- Abi-Saab W, Seibyl JP, D'Souza C, Karper LP, Gueorgueva R, Abi-Dargham A, Wong ML, Rajhans S, Erdos JP, Heninger GR, Charney DS, Krystal JH. Ritanserin antagonism of m-chlorophenylpiperazine effects in neuroleptic-free schizophrenics patients: support for serotonin-2 receptor modulation of schizophrenia symptoms. Psychopharmacology 2002, 162: 55-62. PMID: 12107618, DOI: 10.1007/s00213-002-1057-7.
- Sanacora G, Mason GF, Rothman DL, Krystal JH. Increased Occipital Cortex GABA Concentrations in Depressed Patients After Therapy With Selective Serotonin Reuptake Inhibitors. American Journal Of Psychiatry 2002, 159: 663-665. PMID: 11925309, DOI: 10.1176/appi.ajp.159.4.663.
- Stine SM, Southwick SM, Petrakis IL, Kosten TR, Charney DS, Krystal JH. Yohimbine-induced withdrawal and anxiety symptoms in opioid-dependent patients. Biological Psychiatry 2002, 51: 642-651. PMID: 11955464, DOI: 10.1016/s0006-3223(01)01292-6.
- Boutros NN, Gelernter J, Gooding DC, Cubells J, Young A, Krystal JH, Kosten T. Sensory gating and psychosis vulnerability in cocaine-dependent individuals: preliminary data. Biological Psychiatry 2002, 51: 683-686. PMID: 11955469, DOI: 10.1016/s0006-3223(01)01237-9.
- Abi-Saab WM, Maggs DG, Jones T, Jacob R, Srihari V, Thompson J, Kerr D, Leone P, Krystal JH, Spencer DD, During MJ, Sherwin RS. Striking Differences in Glucose and Lactate Levels Between Brain Extracellular Fluid and Plasma in Conscious Human Subjects: Effects of Hyperglycemia and Hypoglycemia. Cerebrovascular And Brain Metabolism Reviews 2002, 22: 271-279. PMID: 11891432, DOI: 10.1097/00004647-200203000-00004.
- Jacobsen LK, Gore JC, Skudlarski P, Lacadie CM, Jatlow P, Krystal JH. Impact of intravenous nicotine on BOLD signal response to photic stimulation. Magnetic Resonance Imaging 2002, 20: 141-145. PMID: 12034334, DOI: 10.1016/s0730-725x(02)00494-0.
- Krystal J, Petrakis I, D’Souza D, Mason G, Trevisan L. Alcohol and Glutamate Neurotransmission in Humans. Contemporary Clinical Neuroscience 2002, 389-397. DOI: 10.1007/978-1-59259-306-4_26.
- Commentary: first, do no harm. Then, do some good: ethics and human experimental psychopharmacology.Krystal JH. Commentary: first, do no harm. Then, do some good: ethics and human experimental psychopharmacology. Israel Journal Of Psychiatry And Related Sciences 2002, 39: 89-91. PMID: 12227233.
- Krystal JH, Sanacora G, Blumberg H, Anand A, Charney DS, Marek G, Epperson CN, Goddard A, Mason GF. Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments. Molecular Psychiatry 2002, 7: s71-s80. PMID: 11986998, DOI: 10.1038/sj.mp.4001021.
- Krystal J, Cramer J, Krol W, Kirk G, Rosenheck R. Naltrexone in the Treatment of Alcohol Dependence. New England Journal Of Medicine 2001, 345: 1734-1739. PMID: 11742047, DOI: 10.1056/nejmoa011127.
- Sierra M, Phillips M, Lambert M, Senior C, David A, Krystal J. Lamotrigine in the treatment of depersonalization disorder. The Journal Of Clinical Psychiatry 2001, 62: 826-7. PMID: 11816874, DOI: 10.4088/jcp.v62n1012b.
- Krystal J, D’Souza D. Comment on “ketamine has equal affinity for NMDA receptors and the high-affinity state of the dopamine D2 receptor”. Biological Psychiatry 2001, 50: 555. PMID: 11600110, DOI: 10.1016/s0006-3223(01)01258-6.
- Newcomer J, Krystal J. NMDA receptor regulation of memory and behavior in humans. Hippocampus 2001, 11: 529-542. PMID: 11732706, DOI: 10.1002/hipo.1069.
- Krupitsky E, Burakov A, Romanova T, Grinenko N, Grinenko A, Fletcher J, Petrakis I, Krystal J. Attenuation of Ketamine Effects by Nimodipine Pretreatment in Recovering Ethanol Dependent Men: Psychopharmacologic Implications of the Interaction of NMDA and L-Type Calcium Channel Antagonists. Neuropsychopharmacology 2001, 25: 936-947. PMID: 11750186, DOI: 10.1016/s0893-133x(01)00346-3.
- Petrakis I, Trevisan L, Boutros N, Limoncelli D, Cooney N, Krystal J. Effect of Tryptophan Depletion on Alcohol Cue-Induced Craving in Abstinent Alcoholic Patients. Alcohol Clinical And Experimental Research 2001, 25: 1151-1155. DOI: 10.1097/00000374-200108000-00009.
- Petrakis I, Trevisan L, Boutros N, Limoncelli D, Cooney N, Krystal J. Effect of Tryptophan Depletion on Alcohol Cue‐Induced Craving in Abstinent Alcoholic Patients. Alcohol Clinical And Experimental Research 2001, 25: 1151-1155. PMID: 11505046, DOI: 10.1111/j.1530-0277.2001.tb02329.x.
- Chambers R, Krystal J, Self D. A neurobiological basis for substance abuse comorbidity in schizophrenia. Biological Psychiatry 2001, 50: 71-83. PMID: 11526998, PMCID: PMC2913410, DOI: 10.1016/s0006-3223(01)01134-9.
- Goddard AW, Mason GF, Almai A, Rothman DL, Behar KL, Petroff OA, Charney DS, Krystal JH. Reductions in Occipital Cortex GABA Levels in Panic Disorder Detected With 1H-Magnetic Resonance Spectroscopy. JAMA Psychiatry 2001, 58: 556-561. PMID: 11386984, DOI: 10.1001/archpsyc.58.6.556.
- Mason G, Behar K, Krystal J, Rothman D. Aplicações da ressonância magnética para medidas espectroscópicas da neurotransmissão. Brazilian Journal Of Psychiatry 2001, 23: 6-10. DOI: 10.1590/s1516-44462001000500004.
- Krystal J, D'Souza D, Sanacora G, Goddard A, Charney D. CURRENT PERSPECTIVES ON THE PATHOPHYSIOLOGY OF SCHIZOPHRENIA, DEPRESSION, AND ANXIETY DISORDERS. Medical Clinics Of North America 2001, 85: 559-577. PMID: 11349473, DOI: 10.1016/s0025-7125(05)70329-1.
- Stine S, Grillon C, Morgan III C, Kosten T, Charney D, Krystal J. Methadone patients exhibit increased startle and cortisol response after intravenous yohimbine. Psychopharmacology 2001, 154: 274-281. PMID: 11351934, DOI: 10.1007/s002130000644.
- Jacobsen LK, Giedd JN, Gottschalk C, Kosten TR, Krystal JH. Quantitative Morphology of the Caudate and Putamen in Patients With Cocaine Dependence. American Journal Of Psychiatry 2001, 158: 486-489. PMID: 11229995, DOI: 10.1176/appi.ajp.158.3.486.
- D'Souza D, Krystal J. Psychopharmacological challenge studies in psychiatric research. International Review Of Psychiatry 2001, 13: 40-46. DOI: 10.1080/09540260020024187.
- Boutros N, Lisanby S, Tokuno H, Torello M, Campbell D, Berman R, Malison R, Krystal J, Kosten T. Elevated motor threshold in drug-free, cocaine-dependent patients assessed with transcranial magnetic stimulation. Biological Psychiatry 2001, 49: 369-373. PMID: 11239908, DOI: 10.1016/s0006-3223(00)00948-3.
- D'Souza D, Krystal J. Psychopharmacological challenge studies in psychiatric research. International Review Of Psychiatry 2001, 13: 40-46. DOI: 10.1080/09540260123077.
- Boutros N, Reid M, Petrakis I, Campbell D, Torello M, Krystal J. Similarities in the Disturbances in Cortical Information Processing in Alcoholism and Aging: A Pilot Evoked Potential Study,. International Psychogeriatrics 2000, 12: 513-525. PMID: 11263717, DOI: 10.1017/s1041610200006621.
- Krystal J, Belger A, Abi-Saab W, Moghaddam B, Charney D, Anand A, Madonick S, D’Souza C. Glutamatergic contributions to cognitive dysfunction in schizophrenia. 2000, 126-153. DOI: 10.1093/oso/9780192629937.003.0007.
- Boutros N, Campbell D, Petrakis I, Krystal J, Caporale M, Kosten T. Cocaine use and the mid-latency auditory evoked responses. Psychiatry Research 2000, 96: 117-126. PMID: 11063784, DOI: 10.1016/s0165-1781(00)00207-9.
- Abi-Dargham A, Krystal J. Serotonin Receptors as Targets of Antipsychotic Medications. Handbooks In Pharmacology And Toxicology 2000, 20000744: 79-107. DOI: 10.1201/9781420041774.ch6.
- George T, Krystal J. Comorbidity of psychiatric and substance abuse disorders. Current Opinion In Psychiatry 2000, 13: 327-331. DOI: 10.1097/00001504-200005000-00015.
- Belger A, Krystal J. 203. Working memory: constructs, neural circuits, and pharmacological modulation. Biological Psychiatry 2000, 47: s62. DOI: 10.1016/s0006-3223(00)00295-x.
- Abi-Saab W, Spencer D, Srihari V, Thompson J, Roth R, Sherwin R, Krystal J. 458. Extracellular levels of GABA and glutamate increase in response to direct electrical stimulation of the hippocampus in humans: an in vivo microdialysis study. Biological Psychiatry 2000, 47: s140. DOI: 10.1016/s0006-3223(00)00728-9.
- Hoffman R, Boutros N, Berman R, Hu S, Rachid F, Schaffer N, Krystal J, Charney D. 401. One Hertz rTMS of left temporoparietal cortex in schizophrenic patients reporting auditory hallucinations. Biological Psychiatry 2000, 47: s122-s123. DOI: 10.1016/s0006-3223(00)00670-3.
- Boutros N, Reid C, Campbell D, Torello M, Krystal J. 455. Sensory gating in older healthy adults. Biological Psychiatry 2000, 47: s139. DOI: 10.1016/s0006-3223(00)00725-3.
- Hoffman R, Boutros N, Hu S, Berman R, Krystal J, Charney D. Transcranial magnetic stimulation and auditory hallucinations in schizophrenia. The Lancet 2000, 355: 1073-1075. PMID: 10744097, DOI: 10.1016/s0140-6736(00)02043-2.
- Laruelle M, Abi-Dargham A, van Dyck C, Gil R, D’Souza D, Krystal J, Seibyl J, Baldwin R, Innis R. Dopamine and serotonin transporters in patients with schizophrenia: an imaging study with [123I]β-CIT. Biological Psychiatry 2000, 47: 371-379. PMID: 10704949, DOI: 10.1016/s0006-3223(99)00257-7.
- D’Souza D, Gil R, Cassello K, Morrissey K, Abi-Saab D, White J, Sturwold R, Bennett A, Karper L, Zuzarte E, Charney D, Krystal J. IV glycine and oral d-cycloserine effects on plasma and CSF amino acids in healthy humans. Biological Psychiatry 2000, 47: 450-462. PMID: 10704956, DOI: 10.1016/s0006-3223(99)00133-x.
- Anand A, Charney DS, Oren DA, Berman RM, Hu XS, Cappiello A, Krystal JH. Attenuation of the Neuropsychiatric Effects of Ketamine With Lamotrigine: Support for Hyperglutamatergic Effects of N-methyl-D-aspartate Receptor Antagonists. JAMA Psychiatry 2000, 57: 270-276. PMID: 10711913, DOI: 10.1001/archpsyc.57.3.270.
- Berman R, Cappiello A, Anand A, Oren D, Heninger G, Charney D, Krystal J. Antidepressant effects of ketamine in depressed patients. Biological Psychiatry 2000, 47: 351-354. PMID: 10686270, DOI: 10.1016/s0006-3223(99)00230-9.
- Krystal J, Bremner J, D’Souza D, Anand A, Southwick S, Charney D. The Emerging Neurobiology of Dissociative States. Springer Series On Stress And Coping 2000, 307-320. DOI: 10.1007/978-1-4615-4177-6_22.
- D'Souza D, Abi-Saab W, Madonick S, Wray Y, Forselius K, MacDougall L, Brush L, Cassello K, Krystal J. Cannabinoids & psychosis: Evidence from studies with I.V THC in schizophrenic patients and controls. Schizophrenia Research 2000, 41: 33. DOI: 10.1016/s0920-9964(00)90371-2.
- D'Souza D, Madonick S, Abi-Saab W, Wray Y, MacDougall L, Brush L, Cassello K, Krystal J. Dose-response of acute ethanol administration in schizophrenic patients and controls. Schizophrenia Research 2000, 41: 247. DOI: 10.1016/s0920-9964(00)90923-x.
- Krystal J, D'Souza D, Belger A, Madonick S, Cossello K. Ketamine and amphetamine interactions in healthy humans: Further insights into glutamate-dopamine interactions. Schizophrenia Research 2000, 41: 235-236. DOI: 10.1016/s0920-9964(00)90891-0.
- Anand A, Berman R, Charney D, Krystal J. Attenuation of ketamine effects in healthy humans by lamotrigine, a drug that reduces glutamate release. Schizophrenia Research 2000, 41: 33. DOI: 10.1016/s0920-9964(00)90372-4.
- Krystal J, Bennett A, Abi-Saab D, Belger A, Karper L, D’Souza D, Lipschitz D, Abi-Dargham A, Charney D. Dissociation of ketamine effects on rule acquisition and rule implementation: possible relevance to NMDA receptor contributions to executive cognitive functions. Biological Psychiatry 2000, 47: 137-143. PMID: 10664830, PMCID: PMC10060085, DOI: 10.1016/s0006-3223(99)00097-9.
- Sanacora G, Mason G, Krystal J. Impairment of GABAergic Transmission in Depression: New Insights from Neuroimaging Studies. Critical Reviews In Neurobiology 2000, 14: 23. PMID: 11253954, DOI: 10.1615/critrevneurobiol.v14.i1.20.
- Krystal J, Belger A, D'Souza D, Anand A, Charney D, Aghajanian G, Moghaddam B. Therapeutic Implications of the Hyperglutamatergic Effects of NMDA Antagonists. Neuropsychopharmacology 1999, 21: s143-s157. DOI: 10.1016/s0893-133x(99)00102-5.
- Gibbons R, Brown B, Azarnoff D, Bunney W, Cancro R, Gillin J, Hullett S, Killam K, Krystal J, Kupfer D, Stolley P, Pope A, French G. Assessment of the Safety and Efficacy Data for the Hypnotic Halcion (R) : Results of an Analysis by an Institute of Medicine Committee. Journal Of The American Statistical Association 1999, 94: 993. DOI: 10.2307/2669913.
- Gibbons R, Brown B, Azarnoff D, Bunney W, Cancro R, Gillin J, Hullett S, Killam K, Krystal J, Kupfer D, Stolley P, Pope A, French G. Assessment of the Safety and Efficacy Data for the Hypnotic Halcion(R): Results of an Analysis by an Institute of Medicine Committee. Journal Of The American Statistical Association 1999, 94: 993-1002. DOI: 10.1080/01621459.1999.10473852.
- Boutros N, Belger A, Campbell D, D’Souza C, Krystal J. Comparison of four components of sensory gating in schizophrenia and normal subjects: a preliminary report. Psychiatry Research 1999, 88: 119-130. PMID: 10622348, DOI: 10.1016/s0165-1781(99)00074-8.
- Sanacora G, Mason GF, Rothman DL, Behar KL, Hyder F, Petroff OA, Berman RM, Charney DS, Krystal JH. Reduced Cortical γ-Aminobutyric Acid Levels in Depressed Patients Determined by Proton Magnetic Resonance Spectroscopy. JAMA Psychiatry 1999, 56: 1043-1047. PMID: 10565505, DOI: 10.1001/archpsyc.56.11.1043.
- D’Souza D, Berman R, Krystal J, Charney D. Symptom provocation studies in psychiatric disorders: scientific value, risks, and future. Biological Psychiatry 1999, 46: 1060-1080. PMID: 10536743, DOI: 10.1016/s0006-3223(99)00209-7.
- Verhoeff N, Soares J, D’Souza C, Gil R, Degen K, Abi-Dargham A, Zoghbi S, Fujita M, Rajeevan N, Seibyl J, Krystal J, van Dyck C, Charney D, Innis R. [123I]Iomazenil SPECT benzodiazepine receptor imaging in schizophrenia. Psychiatry Research 1999, 91: 163-173. PMID: 10641580, DOI: 10.1016/s0925-4927(99)00027-x.
- Southwick SM, Paige S, Morgan CA, Bremner JD, Krystal JH, Charney DS. Neurotransmitter alterations in PTSD: catecholamines and serotonin. Seminars In Clinical Neuropsychiatry 1999, 4: 242-8. PMID: 10553029, DOI: 10.153/scnp00400242.
- Chambers RA, Bremner JD, Moghaddam B, Southwick SM, Charney DS, Krystal JH. Glutamate and post-traumatic stress disorder: toward a psychobiology of dissociation. Seminars In Clinical Neuropsychiatry 1999, 4: 274-81. PMID: 10553033, DOI: 10.153/scnp00400274.
- Krystal J. NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disorders. Harvard Review Of Psychiatry 1999, 7: 125-143. DOI: 10.1093/hrp/7.3.125.
- Krupitsky E, Burakov A, Romanova T, Vegso S, Krystal J. Nimodipine attenuates psychotigenic effects of ketamine in humans. European Neuropsychopharmacology 1999, 9: 347. DOI: 10.1016/s0924-977x(99)80514-8.
- Krystal J, D'Souza C, Petrakis I, Belger A, Berman R, Charney D, AbiSaab W, Madonick S. NMDA Agonists and Antagonists as Probes of Glutamatergic Dysfunction and Pharmacotherapies in Neuropsychiatric Disorders. Harvard Review Of Psychiatry 1999, 7: 125-143. PMID: 10483932, DOI: 10.3109/hrp.7.3.125.
- Petrakis I, Trevisan L, D'Souza C, Gil R, Krasnicki S, Webb E, Heninger G, Cooney N, Krystal J. CSF Monoamine Metabolite and Beta Endorphin Levels in Recently Detoxified Alcoholics and Healthy Controls. Alcohol Clinical And Experimental Research 1999, 23: 1336. DOI: 10.1097/00000374-199908000-00007.
- Petrakis I, Trevisan L, D'Souza C, Gil R, Krasnicki S, Webb E, Heninger G, Cooney N, Krystal J. CSF Monoamine Metabolite and Beta Endorphin Levels in Recently Detoxified Alcoholics and Healthy Controls: Prediction of Alcohol Cue‐Induced Craving? Alcohol Clinical And Experimental Research 1999, 23: 1336-1341. PMID: 10470976, DOI: 10.1111/j.1530-0277.1999.tb04355.x.
- Hoffman R, Boutros N, Berman R, Roessler E, Belger A, Krystal J, Charney D. Transcranial magnetic stimulation of left temporoparietal cortex in three patients reporting hallucinated “voices”. Biological Psychiatry 1999, 46: 130-132. PMID: 10394483, DOI: 10.1016/s0006-3223(98)00358-8.
- Delgado P, Miller H, Salomon R, Licinio J, Krystal J, Moreno F, Heninger G, Charney D. Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action. Biological Psychiatry 1999, 46: 212-220. PMID: 10418696, DOI: 10.1016/s0006-3223(99)00014-1.
- Krystal J, D’Souza D, Karper L, Bennett A, Abi-Dargham A, Abi-Saab D, Cassello K, Bowers Jr. M, Vegso S, Heninger G, Charney D, Bowers M. Interactive effects of subanesthetic ketamine and haloperidol in healthy humans. Psychopharmacology 1999, 145: 193-204. PMID: 10463321, DOI: 10.1007/s002130051049.
- Abi-Dargham A, Laruelle M, Krystal J, D'Souza C, Zoghbi S, Baldwin R, Seibyl J, Mawlawi O, de Erasquin G, Charney D, Innis R. No Evidence of Altered In Vivo Benzodiazepine Receptor Binding in Schizophrenia. Neuropsychopharmacology 1999, 20: 650-661. PMID: 10327433, DOI: 10.1016/s0893-133x(98)00107-9.
- Behar KL, Rothman DL, Petersen KF, Hooten M, Delaney R, Petroff OA, Shulman GI, Navarro V, Petrakis IL, Charney DS, Krystal JH. Preliminary Evidence of Low Cortical GABA Levels in Localized 1H-MR Spectra of Alcohol-Dependent and Hepatic Encephalopathy Patients. American Journal Of Psychiatry 1999, 156: 952-954. PMID: 10360140, DOI: 10.1176/ajp.156.6.952.
- Sanacora G, Rothman D, Krystal J. Applications of Magnetic Resonance Spectroscopy to Psychiatry. The Neuroscientist 1999, 5: 192-196. DOI: 10.1177/107385849900500316.
- Bunney W, Azarnoff D, Brown B, Cancro R, Gibbons R, Gillin J, Hullett S, Killam K, Kupfer D, Krystal J, Stolley P, French G, Pope A. Report of the Institute of Medicine Committee on the Efficacy and Safety of Halcion. JAMA Psychiatry 1999, 56: 349-352. PMID: 10197830, DOI: 10.1001/archpsyc.56.4.349.
- Sanacora G, Mason G, Rothman D, Berman R, Charney D, Ciarcia J, Krystal J. 1. ECT Effects on Cortical GABA Levels as Determined by 1H-MRS. Journal Of Ect 1999, 15: 102. DOI: 10.1097/00124509-199903000-00009.
- Krystal J, D'Souza D, Madonick S, Petrakis I. Toward a rational pharmacotherapy of comorbid substance abuse in schizophrenic patients. Schizophrenia Research 1999, 35: s35-s49. PMID: 10190224, DOI: 10.1016/s0920-9964(98)00162-5.
- Fujita M, Woods S, Verhoeff N, Abi-Dargham A, Baldwin R, Zoghbi S, Soares J, Jatlow P, Krystal J, Rajeevan N, Charney D, Seibyl J, Innis R. Changes of benzodiazepine receptors during chronic benzodiazepine administration in humans. European Journal Of Pharmacology 1999, 368: 161-172. PMID: 10193652, DOI: 10.1016/s0014-2999(99)00013-8.
- Belger A, Puce A, Krystal J, Gore J, Goldman‐Rakic P, McCarthy G. Dissociation of mnemonic and perceptual processes during spatial and nonspatial working memory using fMRI. Human Brain Mapping 1998, 6: 14-32. PMID: 9673660, PMCID: PMC6873355, DOI: 10.1002/(sici)1097-0193(1998)6:1<14::aid-hbm2>3.0.co;2-o.
- Krystal JH, D'Souza DC. Editorial. Biological Psychiatry 1998, 44: 1075-1076. PMID: 9836009, DOI: 10.1016/s0006-3223(98)00284-4.
- Abi-Dargham A, Krystal JH, Anjilvel S, Scanley BE, Zoghbi S, Baldwin RM, Rajeevan N, Ellis S, Petrakis IL, Seibyl JP, Charney DS, Laruelle M, Innis RB. Alterations of Benzodiazepine Receptors in Type II Alcoholic Subjects Measured With SPECT and 123IIomazenil. American Journal Of Psychiatry 1998, 155: 1550-1555. PMID: 9812116, DOI: 10.1176/ajp.155.11.1550.
- Abi-Saab W, D'Souza D, Moghaddam B, Krystal J. The NMDA Antagonist Model for Schizophrenia: Promise and Pitfalls. Pharmacopsychiatry 1998, 31: 104-109. PMID: 9754841, DOI: 10.1055/s-2007-979354.
- Sernyak M, Glazer W, Heninger G, Charney D, Woods S, Petrakis I, Krystal J, Price L. Naltrexone Augmentation of Neuroleptics in Schizophrenia. Journal Of Clinical Psychopharmacology 1998, 18: 248-251.. PMID: 9617985, DOI: 10.1097/00004714-199806000-00011.
- Abi-Dargham A, Gil R, Krystal J, Baldwin RM, Seibyl JP, Bowers M, van Dyck CH, Charney DS, Innis RB, Laruelle M. Increased Striatal Dopamine Transmission in Schizophrenia: Confirmation in a Second Cohort. American Journal Of Psychiatry 1998, 155: 761-767. PMID: 9619147, DOI: 10.1176/ajp.155.6.761.
- Krystal J, Moghaddam B, Breier A, Goldman-Rakic P, McElvey J. 204. Glutamate, dopamine, the frontal cortex, and schizophrenia. Biological Psychiatry 1998, 43: s60. DOI: 10.1016/s0006-3223(98)90652-7.
- D'Souza D, Belger A, Abi-Saab W, Adams S, Gil R, Larvey K, Cassello K, Sernyak M, Krystal J. 435. Dose-response of THC effects in schizophrenics and healthy controls. Biological Psychiatry 1998, 43: s130-s131. DOI: 10.1016/s0006-3223(98)90883-6.
- Boutros N, Krystal J, Gelernter J. 295. Sensory gating and cocaine induced paranoia. Biological Psychiatry 1998, 43: s89. DOI: 10.1016/s0006-3223(98)90743-0.
- Hoffman R, Boutros N, Berman R, Krystal J, Charney D. 310. Transcranial magnetic stimulation and hallucinated ‘voices’. Biological Psychiatry 1998, 43: s93. DOI: 10.1016/s0006-3223(98)90758-2.
- Krystal JH, Petrakis IL, Webb E, Cooney NL, Karper LP, Namanworth S, Stetson P, Trevisan LA, Charney DS. Dose-Related Ethanol-like Effects of the NMDA Antagonist, Ketamine, in Recently Detoxified Alcoholics. JAMA Psychiatry 1998, 55: 354-360. PMID: 9554431, DOI: 10.1001/archpsyc.55.4.354.
- Hillbrand M, Spitz R, Foster H, Krystal J, Young J. Creatine Kinase Elevations and Aggressive Behavior in Hospitalized Forensic Patients. Psychiatric Quarterly 1998, 69: 69-82. PMID: 9536476, DOI: 10.1023/a:1022137524475.
- Belger A, Kirino E, McCarthy G, Gore J, Krystal J. Assessment of prefrontal activation by infrequent visual targets and non-target novel stimuli in schizophrenia: A functional MRI study. Schizophrenia Research 1998, 29: 106. DOI: 10.1016/s0920-9964(97)88567-2.
- Krystal J, Nagy L, Rasmusson A, Morgan A, Cottrol C, Southwick S, Charney D. Initial Clinical Evidence of Genetic Contributions to Posttraumatic Stress Disorder. Springer Series On Stress And Coping 1998, 657-667. DOI: 10.1007/978-1-4757-5567-1_39.
- Krystal J. Excitatory Amino Acids: Clinical Results with Antagonists. The Yale Journal Of Biology And Medicine 1998, 71: 409-410. PMCID: PMC2578927.
- Measurement of dissociative states with the Clinician‐Administered Dissociative States Scale (CADSS)Bremner J, Krystal J, Putnam F, Southwick S, Marmar C, Charney D, Mazure C. Measurement of dissociative states with the Clinician‐Administered Dissociative States Scale (CADSS). Journal Of Traumatic Stress 1998, 11: 125-136. PMID: 9479681, DOI: 10.1023/a:1024465317902.
- Krystal J, Karper L, Bennett A, D’Souza D, Abi-Dargham A, Morrissey K, Abi-Saab D, Bremner J, Bowers Jr. M, Suckow R, Stetson P, Heninger G, Charney D. Interactive effects of subanesthetic ketamine and subhypnotic lorazepam in humans. Psychopharmacology 1998, 135: 213-229. PMID: 9498724, DOI: 10.1007/s002130050503.
- Trevisan LA, Boutros N, Petrakis IL, Krystal JH. Complications of alcohol withdrawal: pathophysiological insights. Alcohol Research 1998, 22: 61-6. PMID: 15706735, PMCID: PMC6761825.
- Abi-Dargham A, Charney D, Krystal J. Benzodiazepine Receptor Antagonists. CNS Drugs 1997, 8: 244-256. DOI: 10.2165/00023210-199708030-00007.
- Stine S, Krystal J, Petrakis I, Jatlow P, Heninger G, Kosten T, Chamey D. Effect of alpha-methyl-para-tyrosine on response to cocaine challenge. Biological Psychiatry 1997, 42: 181-190. PMID: 9232210, DOI: 10.1016/s0006-3223(96)00331-9.
- Southwick SM, Krystal JH, Bremner JD, Morgan CA, Nicolaou AL, Nagy LM, Johnson DR, Heninger GR, Charney DS. Noradrenergic and Serotonergic Function in Posttraumatic Stress Disorder. JAMA Psychiatry 1997, 54: 749-758. PMID: 9283511, DOI: 10.1001/archpsyc.1997.01830200083012.
- Cramer J, Krystal J, Rosenheck R, Rounsaville B, Krol W, Collins J. P111 Protocol enhancements for a study of alcohol-dependent patients. Contemporary Clinical Trials 1997, 18: s179. DOI: 10.1016/s0197-2456(97)91206-x.
- Krystal J, Webb E, Grillon C, Cooney N, Casal L, Morgan III. C, Southwick S, Davis M, Charney D. Evidence of acoustic startle hyperreflexia in recently detoxified early onset male alcoholics: modulation by yohimbine and m-Chlorophenylpiperazine (mCPP). Psychopharmacology 1997, 131: 207-215. PMID: 9203230, DOI: 10.1007/s002130050285.
- SOUTHWICK S, MORGAN CA, BREMNER A, GRILLON C, KRYSTAL J, NAGY L, CHARNEY D. Noradrenergic Alterations in Posttraumatic Stress Disorder. Annals Of The New York Academy Of Sciences 1997, 821: 125-141. PMID: 9238199, DOI: 10.1111/j.1749-6632.1997.tb48274.x.
- Bremner JD, Licinio J, Darnell A, Krystal JH, Owens MJ, Southwick SM, Nemeroff CB, Charney DS. Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder. American Journal Of Psychiatry 1997, 154: 624-629. PMID: 9137116, PMCID: PMC3233756, DOI: 10.1176/ajp.154.5.624.
- Bremner JD, Innis RB, Salomon RM, Staib LH, Ng CK, Miller HL, Bronen RA, Krystal JH, Duncan J, Rich D, Price LH, Malison R, Dey H, Soufer R, Charney DS. Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Tryptophan Depletion—Induced Depressive Relapse. JAMA Psychiatry 1997, 54: 364-374. PMID: 9107153, DOI: 10.1001/archpsyc.1997.01830160092012.
- Bremner JD, Innis RB, Ng CK, Staib LH, Salomon RM, Bronen RA, Duncan J, Southwick SM, Krystal JH, Rich D, Zubal G, Dey H, Soufer R, Charney DS. Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Yohimbine Administration in Combat-Related Posttraumatic Stress Disorder. JAMA Psychiatry 1997, 54: 246-254. PMID: 9075465, DOI: 10.1001/archpsyc.1997.01830150070011.
- Abi-Dargham A, Laruelle M, Aghajanian GK, Charney D, Krystal J. The role of serotonin in the pathophysiology and treatment of schizophrenia. Journal Of Neuropsychiatry 1997, 9: 1-17. PMID: 9017523, DOI: 10.1176/jnp.9.1.1.
- D’Souza D, Gil R, Zuzarte E, Zimmerman L, Abi-Saab D, Damon D, White J, Semyak M, Krystal J. 602 Tetrahydrocannabinol effects in schizophrenic subjects & healthy controls. Schizophrenia Research 1997, 24: 213. DOI: 10.1016/s0920-9964(97)82610-2.
- Zuzarte E, D’Souza D, Gil R, Genovese A, White J, Charney D, Krystal J. 617 Dose-related ethanol effects in schizophrenic patients. Schizophrenia Research 1997, 24: 218. DOI: 10.1016/s0920-9964(97)82625-4.
- Behar K, Rothman D, D’Souza D, Gil R, Petroff O, Abi-Saab D, Zuzarte E, Hooten M, Petrakis I, Sernyak M, White J, Webb E, Charnay D, Krystal J. 496 Preliminary assessment of cortical gaba levels in schizophrenics using magnetic resonance spectroscopy. Schizophrenia Research 1997, 24: 175-176. DOI: 10.1016/s0920-9964(97)82504-2.
- Laruelle M, Abi-Dargham A, Krystal J, Charney D, Innis R. 507 In vivo evaluation of dopamine synaptic funcflon in untreated schizophrenic patients. Schizophrenia Research 1997, 24: 179. DOI: 10.1016/s0920-9964(97)82515-7.
- Zuzarte E, D’Souza D, Gil R, White J, AbiSaab D, Charney D, Krystal J. 618 Evaluation of lorazepam blockade of M-chlorophenylpiperazine (MCPP) effects in schizophrenia. Schizophrenia Research 1997, 24: 218. DOI: 10.1016/s0920-9964(97)82626-6.
- D’Souza D, Gil R, Zuzarte E, Abi-Saab D, Damon D, White J, Zimmerman L, Krystal J. 601 Glycine ketamine interactions in healthy humans. Schizophrenia Research 1997, 24: 213. DOI: 10.1016/s0920-9964(97)82609-6.
- Belger A, Taqqu Y, Krystal J. 357 Behavioral dissociation of working memory and selective attention functions in schizophrenia. Schizophrenia Research 1997, 24: 129-130. DOI: 10.1016/s0920-9964(97)82365-1.
- Belger A, McNulty A, Krystal J. 356 Behavioral assessment of frontal/ cingulate attention deficits in schizophrenia. Schizophrenia Research 1997, 24: 129. DOI: 10.1016/s0920-9964(97)82364-x.
- Salomon R, Miller H, Krystal J, Heninger G, Charney D. Lack of behavioral effects of monoamine depletion in healthy subjects. Biological Psychiatry 1997, 41: 58-64. PMID: 8988796, DOI: 10.1016/0006-3223(95)00670-2.
- Petrakis I, Krystal J. Neuroscience: implications for treatment. Alcohol Research 1997, 21: 157-60. PMID: 15704353, PMCID: PMC6826829.
- Petrakis I, Satel S, Stine S, Kosten T, Namanworth S, Charney D, Krystal J. AMPT Effects on Cue‐Induced Craving for Cocaine. American Journal On Addictions 1996, 5: 313-320. DOI: 10.1111/j.1521-0391.1996.tb00317.x.
- Laruelle M, Abi-Dargham A, van Dyck CH, Gil R, D'Souza CD, Erdos J, McCance E, Rosenblatt W, Fingado C, Zoghbi SS, Baldwin RM, Seibyl JP, Krystal JH, Charney DS, Innis RB. Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 9235-9240. PMID: 8799184, PMCID: PMC38625, DOI: 10.1073/pnas.93.17.9235.
- McCarthy G, Puce A, Constable T, Krystal J, Gore J, Goldman-Rakic P. Activation of Human Prefrontal Cortex during Spatial and Nonspatial Working Memory Tasks Measured by Functional MRI. Cerebral Cortex 1996, 6: 600-611. PMID: 8670685, DOI: 10.1093/cercor/6.4.600.
- Bremner JD, Krystal JH, Charney DS, Southwick SM. Neural Mechanisms in dissociative amnesia for childhood abuse: relevance to the current controversy surrounding the "false memory syndrome". American Journal Of Psychiatry 1996, 153: 71-82. PMID: 8659644, DOI: 10.1176/ajp.153.7.71.
- D’Souza D, Abi-Saab D, Damon D, White J, Gil R, Krystal J. O-22-11 Dose response of D-Cycloserine, a partial NMDA-Glycine site agonist, in schizophrenia. European Neuropsychopharmacology 1996, 6: 149. DOI: 10.1016/0924-977x(96)87994-6.
- Bremner J, Krystal J, Southwick S, Charney D. Noradrenergic mechanisms in stress and anxiety: I. preclinical studies. Synapse 1996, 23: 28-38. PMID: 8723133, DOI: 10.1002/(sici)1098-2396(199605)23:1<28::aid-syn4>3.0.co;2-j.
- Bremner J, Krystal J, Southwick S, Charney D. Noradrenergic mechanisms in stress and anxiety: II. Clinical studies. Synapse 1996, 23: 39-51. PMID: 8723134, DOI: 10.1002/(sici)1098-2396(199605)23:1<39::aid-syn5>3.0.co;2-i.
- Laruelle M, Abi-Dargham A, van Dyck C, Krystal J, Charney D, Innis R. 208. Increased striatal dopamine release in drug free schizophrenic subjects. Biological Psychiatry 1996, 39: 560. DOI: 10.1016/0006-3223(96)84153-9.
- Gil R, D’Souza D, Zuzarte E, Damon D, Genovese A, Boutros N, Abi-Dargham A, Innis R, Charney D, Krystal J. 326. GABA-serotonin interactions in healthy subjects: Implications for psychosis. Biological Psychiatry 1996, 39: 595-596. DOI: 10.1016/0006-3223(96)84271-5.
- Krystal J, Compere S, Nestler E, Rasmussen K. Nimodipine reduction of naltrexone-precipitated locus coeruleus activation and abstinence behavior in morphine-dependent rats. Physiology & Behavior 1996, 59: 863-866. PMID: 8778878, DOI: 10.1016/0031-9384(95)02206-6.
- Hillbrand M, Young J, Krystal J. Recurrent self-injurious behavior in forensic patients. Psychiatric Quarterly 1996, 67: 33-45. PMID: 8623037, DOI: 10.1007/bf02244273.
- D'Souza D, White J, Abi-Saab D, Damon D, Gil R, Zuzarte E, Krystal J. Dose response of oral D-cycloserine in unmedicated and medicated schizophrenics. Schizophrenia Research 1996, 18: 134. DOI: 10.1016/0920-9964(96)85447-8.
- Laruelle M, Abi-Dargham A, Gil R, van Dyck C, Erdos J, D'Souza D, Rosenblatt W, McCance-Katz E, Zea-Ponce Y, Zoghbi S, Baldwin R, Hoffer P, Krystal J, Charney D, Innis R. SPECT imaging of synaptic dopamine release in drug free schizophrenic patients: An experimental validation of the dopamine hypothesis of schizophrenia. Schizophrenia Research 1996, 18: 198-199. DOI: 10.1016/0920-9964(96)85619-2.
- Miller HL, Delgado PL, Salomon RM, Berman R, Krystal JH, Heninger GR, Charney DS. Clinical and Biochemical Effects of Catecholamine Depletion on Antidepressant-Induced Remission of Depression. JAMA Psychiatry 1996, 53: 117-128. PMID: 8629887, DOI: 10.1001/archpsyc.1996.01830020031005.
- Karper LP, Freeman GK, Grillon C, Morgan CA, Charney DS, Krystal JH. Preliminary evidence of an association between sensorimotor gating and distractibility in psychosis. Journal Of Neuropsychiatry 1996, 8: 60-66. PMID: 8845703, DOI: 10.1176/jnp.8.1.60.
- Krystal J, Bennett A, Bremner J, Southwick S, Charney D. Recent Developments in the Neurobiology of Dissociation. 1996, 163-190. DOI: 10.1007/978-1-4899-0310-5_8.
- Petrakis I, Satel S, Stine S, Kosten T, Namanworth S, Charney D, Krystal J. AMPT Effects on Cue-Induced Craving for Cocaine. American Journal On Addictions 1996, 5: 313-320. DOI: 10.3109/10550499608995682.
- Lam RW, Zis AP, Grewal A, Delgado PL, Charney DS, Krystal JH. Effects of Rapid Tryptophan Depletion in Patients With Seasonal Affective Disorder in Remission After Light Therapy. JAMA Psychiatry 1996, 53: 41-44. PMID: 8540776, DOI: 10.1001/archpsyc.1996.01830010043007.
- Krystal JH, Deutsch DN, Charney DS. The biological basis of panic disorder. The Journal Of Clinical Psychiatry 1996, 57 Suppl 10: 23-31; discussion 32-3. PMID: 8917129.
- Seibyl JP, Zea-Ponce Y, Brenner L, Baldwin RM, Krystal JH, Offord SJ, Mochoviak S, Charney DS, Hoffer PB, Innis RB. Continuous intravenous infusion of iodine-123-IBZM for SPECT determination of human brain dopamine receptor occupancy by antipsychotic agent RWJ-37796. Journal Of Nuclear Medicine 1996, 37: 11-5. PMID: 8543979.
- Krystal JH, Webb E, Cooney NL, Kranzler HR, Southwick SW, Heninger GR, Charney DS. Serotonergic and noradrenergic dysregulation in alcoholism: m- chlorophenylpiperazine and yohimbine effects in recently detoxified alcoholics and healthy comparison subjects. American Journal Of Psychiatry 1996, 153: 83-92. PMID: 8540598, DOI: 10.1176/ajp.153.1.83.
- Bremner J, Krystal J, Southwick S, Charney D. Functional neuroanatomical correlates of the effects of stress on memory. Journal Of Traumatic Stress 1995, 8: 527-553. DOI: 10.1007/bf02102888.
- Stine S, Krystal J, Kosten T, Charney D. Mazindol treatment for cocaine dependence. Drug And Alcohol Dependence 1995, 39: 245-252. PMID: 8556974, DOI: 10.1016/0376-8716(95)01174-4.
- Bremner J, Krystal J, Southwick S, Charney D. Functional neuroanatomical correlates of the effects of stress on memory. Journal Of Traumatic Stress 1995, 8: 527-553. PMID: 8564272, DOI: 10.1002/jts.2490080403.
- D'Souza D, Charney D, Krystal J. Glycine Site Agonists of the NMDA Receptor: A Review. CNS Neuroscience & Therapeutics 1995, 1: 227-260. DOI: 10.1111/j.1527-3458.1995.tb00285.x.
- Randall P, Bremner J, Krystal J, Nagy L, Heninger G, Nicolaou A, Charney D. Effects of the benzodiazepine antagonist flumazenil in PTSD. Biological Psychiatry 1995, 38: 319-324. PMID: 7495926, DOI: 10.1016/0006-3223(94)00306-n.
- Goddard A, Charney D, Germine M, Woods S, Heninger G, Krystal J, Goodman W, Price L. Effects of tryptophan depletion on responses to yohimbine in healthy human subjects. Biological Psychiatry 1995, 38: 74-85. PMID: 7578653, DOI: 10.1016/0006-3223(94)00223-p.
- Satel SL, Krystal JH, Delgado PL, Kosten TR, Charney DS. Tryptophan depletion and attenuation of cue-induced craving for cocaine. American Journal Of Psychiatry 1995, 152: 778-783. PMID: 7726319, DOI: 10.1176/ajp.152.5.778.
- Karper L, Grillon C, Abi-Saab D, Morgan C, Charney D, Krystal J. The effect of ketamine on pre-pulse inhibition and attention. Schizophrenia Research 1995, 15: 180. DOI: 10.1016/0920-9964(95)95554-m.
- Belger A, McCarthy G, Gore J, Puce A, Constable T, Krystal J. Evaluation of frontal and parietal association cortex contributions to attention using fMRI. Schizophrenia Research 1995, 15: 76. DOI: 10.1016/0920-9964(95)95239-6.
- Krystal J, Karper L, D'Souza C, Webb E, Bennett A, Abi-Dargham A, Petrakis I, Brenner L, Morrissey K, Abi-Saab D, Charney D. Differentiating nmda dysregulation in schizophrenia and alcoholism using ketamine. Schizophrenia Research 1995, 15: 156. DOI: 10.1016/0920-9964(95)95484-q.
- D'Souza D, Morrissey K, Abi-Saab D, Damon D, Gil R, Bennett A, Krystal J. Intravenous glycine and oral d-Cycloserine effects on CSF Amino acids, plasma hormones and behavior in healthy humans: Implications for schizophrenia. Schizophrenia Research 1995, 15: 147. DOI: 10.1016/0920-9964(95)95456-j.
- Bennett A, Abi-Saab D, Karper L, D'Souza D, Abi-Dargham A, Charney D, Krystal J. Ketamine impairs learning, but not procedural expression, on the wisconsin card sorting test. Schizophrenia Research 1995, 15: 108-109. DOI: 10.1016/0920-9964(95)95333-5.
- Krystal J, Karper L, Bennett A, Abi-Saab D, D'Souza C, Abi-Dargham A, Charney D. Modulating ketamine-induced thought disorder with lorazepam and haloperidol in humans. Schizophrenia Research 1995, 15: 156-157. DOI: 10.1016/0920-9964(95)95485-r.
- Abi-Dargham A, Krystal J, Laruelle M, D'Souza D, Zoghbi S, Brenner L, Gil R, Sernyak M, Baldwin R, Zubal G, Hoffer P, Charney D, Innis R. Spect imaging of the benzodiazepine receptor in schizophrenics and healthy subjects. Schizophrenia Research 1995, 15: 75. DOI: 10.1016/0920-9964(95)95236-3.
- McDougle C, Price L, Heninger G, Krystal J, Charney D. Noradrenergic response to acute ethanol administration in heathly subjects: comparison with intravenous yohimbine. Psychopharmacology 1995, 118: 127-135. PMID: 7617798, DOI: 10.1007/bf02245830.
- HILLBRAND M, YOUNG J, KRYSTAL J. Discontinuing Anticonvulsant Treatment of Aggression. Journal Of Neuropsychiatry 1995, 7: 116-a-117. PMID: 7711482, DOI: 10.1176/jnp.7.1.116-a.
- Morgan CA, Grillon C, Southwick SM, Nagy LM, Davis M, Krystal JH, Charney DS. Yohimbine facilitated acoustic startle in combat veterans with post-traumatic stress disorder. Psychopharmacology 1995, 117: 466-471. PMID: 7604149, DOI: 10.1007/bf02246220.
- Southwick S, Krystal J, Johnson D, Charney D. Neurobiology of Post-Traumatic Stress Disorder. Springer Series On Stress And Coping 1995, 49-72. DOI: 10.1007/978-1-4899-1034-9_4.
- Southwick S, Krystal J, Charney D. Relationship of Panic Disorder to Posttraumatic Stress Disorder-Reply. JAMA Psychiatry 1995, 52: 77-78. DOI: 10.1001/archpsyc.1995.03950130077012.
- Krystal J, Woods S, Kosten T, Rosen M, Seibyl J, Van Dyck C, Price L, Zubal I, Hoffer P, Charney D. Opiate Dependence and Withdrawal: Preliminary Assessment Using Single Photon Emission Computerized Tomography (SPECT). The American Journal Of Drug And Alcohol Abuse 1995, 21: 47-63. PMID: 7762544, DOI: 10.3109/00952999509095229.
- Karper L, Bennett A, Erdos J, Krystal J. ANTIPSYCHOTICS, LITHIUM, BENZODIAZEPINES, BETA-BLOCKERS. Journal Of Offender Rehabilitation 1994, 21: 203-222. DOI: 10.1300/j076v21n03_13.
- van Dyck C, Rosen M, Thomas H, McMahon T, Wallace E, O'Connor P, Sullivan M, Krystal J, Hoffer P, Woods S, Kosten T. SPECT regional cerebral blood flow alterations in naltrexone-precipitated withdrawal from buprenorphine. Psychiatry Research 1994, 55: 181-191. PMID: 7701033, DOI: 10.1016/0925-4927(94)90013-2.
- Salomon R, Delgado P, Licinio J, Krystal J, Heninger G, Charney D. Effects of sleep deprivation on serotonin function in depression. Biological Psychiatry 1994, 36: 840-846. PMID: 7893848, DOI: 10.1016/0006-3223(94)90595-9.
- Krystal JH, Webb E, Cooney N, Kranzler HR, Charney DS. Specificity of Ethanollike Effects Elicited by Serotonergic and Noradrenergic Mechanisms. JAMA Psychiatry 1994, 51: 898-911. PMID: 7944878, DOI: 10.1001/archpsyc.1994.03950110058008.
- D'SOUZA D, BENNETT A, ABI-DARGHAM A, KRYSTAL J. Precipitation of a Psychoneuromotor Syndrome by Fluoxetine in a Haloperidol-. Journal Of Clinical Psychopharmacology 1994, 14: 361-362. PMID: 7806697, DOI: 10.1097/00004714-199410000-00018.
- Brenner L, Karper L, Krystal J. Short-Term Use of Disulfiram With Clozapine. Journal Of Clinical Psychopharmacology 1994, 14: 213-214. PMID: 8027424, DOI: 10.1097/00004714-199406000-00016.
- Southwick S, Bremner D, Krystal J, Charney D. Psychobiologic Research in Post-Traumatic Stress Disorder. Psychiatric Clinics Of North America 1994, 17: 251-264. PMID: 7937357, DOI: 10.1016/s0193-953x(18)30112-6.
- D'Souza D, Bennett A, Karper L, Gil R, Morrissey K, Abi-Saab D, Charney D, Krystal J. I.V. glycine/d-cycloserine to facilitate NMDA function in humans. Biological Psychiatry 1994, 35: 734. DOI: 10.1016/0006-3223(94)91085-5.
- Krystal J, Southwick S, Charney D. Alcohol Dependence May Be the Missing Link Between Posttraumatic Stress Disorder and Panic-Reply. JAMA Psychiatry 1994, 51: 430-430. DOI: 10.1001/archpsyc.1994.03950050090014.
- Karper L, Grillon C, Lysaker P, Bell M, Charney D, Krystal J. Soft signs, attention, and startle in schizophrenia. Biological Psychiatry 1994, 35: 714. DOI: 10.1016/0006-3223(94)91014-6.
- D'Souza D, Gil R, Abi-Dargham A, Karper L, Abi-Saab D, Morrissey K, Brenner L, Charney D, Krystal J. Tryptophan depletion paradigm: Implications for schizophrenia. Biological Psychiatry 1994, 35: 703. DOI: 10.1016/0006-3223(94)90974-1.
- Krystal JH, Karper LP, Seibyl JP, Freeman GK, Delaney R, Bremner JD, Heninger GR, Bowers MB, Charney DS. Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans: Psychotomimetic, Perceptual, Cognitive, and Neuroendocrine Responses. JAMA Psychiatry 1994, 51: 199-214. PMID: 8122957, DOI: 10.1001/archpsyc.1994.03950030035004.
- D'Souza D, Krystal J. Perturbing the Organism: The Biology of Stressful Experience. The Journal Of Nervous And Mental Disease 1994, 182: 126. DOI: 10.1097/00005053-199402000-00023.
- DOCHERTY N, EVANS I, SLEDGE W, SEIBYL J, KRYSTAL J. Affective Reactivity of Language in Schizophrenia. The Journal Of Nervous And Mental Disease 1994, 182: 98-103. PMID: 8308539, DOI: 10.1097/00005053-199402000-00006.
- HILLBRAND M, KRYSTAL J, SHARPE K, FOSTER H. Clinical Predictors of Self-Mutilation in Hospitalized Forensic Patients. The Journal Of Nervous And Mental Disease 1994, 182: 9-16. PMID: 8277305, DOI: 10.1097/00005053-199401000-00003.
- Licinio J, Seibyl JP, Altemus M, Charney DS, Krystal JH. Elevated CSF levels of interleukin-2 in neuroleptic-free schizophrenic patients. American Journal Of Psychiatry 1993, 150: 1408-1410. PMID: 8102512, DOI: 10.1176/ajp.150.9.1408.
- Krystal JH, Seibyl JP, Price LH, Woods SW, Heninger GR, Aghajanian GK, Charney DS. m-Chlorophenylpiperazine Effects in Neuroleptic-Free Schizophrenic Patients: Evidence Implicating Serotonergic Systems in the Positive Symptoms of Schizophrenia. JAMA Psychiatry 1993, 50: 624-635. PMID: 8102048, DOI: 10.1001/archpsyc.1993.01820200034004.
- Karper L, Bell M, Lysaker P, Seibyl J, Beam-Goulet J, Brenner L, Krystal J. The neurological evaluation scale (NES): Factor analysis and clinical correlates. Schizophrenia Research 1993, 9: 179. DOI: 10.1016/0920-9964(93)90354-l.
- Abi-Dargham A, Seibyl J, Laruelle M, Rattner Z, Zoghbi S, Baldwin R, Ponce Y, Charney D, Hoffer P, Krystal J, Innis R. Spect imaging of the benzodiazepine receptor in humans using [123I]iomazenil. Schizophrenia Research 1993, 9: 191. DOI: 10.1016/0920-9964(93)90389-z.
- Karper L, Freeman G, Morgan C, Grillon C, Charney D, Krystal J. Pre-pulse inhibition of the acoustic startle response and measures of attention in schizophrenic subjects. Schizophrenia Research 1993, 9: 160. DOI: 10.1016/0920-9964(93)90296-u.
- Krystal J, Karper L, Seibyl J, Delaney R, Bremner J, Bowers M, Charney D. Dose-related effects of the NMDA antagonist, ketamine, in healthy humans. Schizophrenia Research 1993, 9: 240-241. DOI: 10.1016/0920-9964(93)90538-t.
- Krystal J, Karper L, Abi-Dargham A, Delaney R, Bremmer J, Bowers M, Charney D. Ketamine effects reduced by lorazepam in healthy humans. Schizophrenia Research 1993, 9: 241. DOI: 10.1016/0920-9964(93)90539-u.
- Charney DS, Deutch AY, Krystal JH, Southwick SM, Davis M. Psychobiologic Mechanisms of Posttraumatic Stress Disorder. JAMA Psychiatry 1993, 50: 294-305. PMID: 8466391, DOI: 10.1001/archpsyc.1993.01820160064008.
- Southwick SM, Krystal JH, Morgan CA, Johnson D, Nagy LM, Nicolaou A, Heninger GR, Charney DS. Abnormal Noradrenergic Function in Posttraumatic Stress Disorder. JAMA Psychiatry 1993, 50: 266-274. PMID: 8466387, DOI: 10.1001/archpsyc.1993.01820160036003.
- NAGY L, KRYSTAL J, CHARNEY D, MERIKANGAS K, WOODS S. Long-Term Outcome of Panic Disorder After Short-Term Imipramine and Behavioral Group Treatment. Journal Of Clinical Psychopharmacology 1993, 13: 16-24. PMID: 8098050, DOI: 10.1097/00004714-199302000-00003.
- Morgan CA, Southwick SM, Grillon C, Davis M, Krystal JH, Charney DS. Yohimbine — facilitated acoustic startle reflex in humans. Psychopharmacology 1993, 110: 342-346. PMID: 7831429, DOI: 10.1007/bf02251291.
- Krystal J. Stress, the Aging Brain, and the Mechanisms of Neuron Death. The Yale Journal Of Biology And Medicine 1993, 66: 109-110. PMCID: PMC2588844.
- SEIBYL J, SATEL S, ANTHONY D, SOUTHWICK S, KRYSTAL J, CHARNEY D. Effects of Cocaine on Hospital Course in Schizophrenia. The Journal Of Nervous And Mental Disease 1993, 181: 31-37. PMID: 8093475, DOI: 10.1097/00005053-199301000-00006.
- Yehuda R, Southwick SM, Krystal JH, Bremner D, Charney DS, Mason JW. Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder. American Journal Of Psychiatry 1993, 150: 83-86. PMID: 8417586, DOI: 10.1176/ajp.150.1.83.
- Karper LP, Salloway SP, Seibyl JP, Krystal JH. Prolonged postictal encephalopathy in two patients with clozapine- induced seizures. Journal Of Neuropsychiatry 1992, 4: 454-457. PMID: 1422175, DOI: 10.1176/jnp.4.4.454.
- Grillon C, Ameli R, Charney D, Krystal J, Braff D. Startle gating deficits occur across prepulse intensities in schizophrenic patients. Biological Psychiatry 1992, 32: 939-943. PMID: 1467378, DOI: 10.1016/0006-3223(92)90183-z.
- Kosten T, Krystal J, Giller E, Frank J, Dan E. Alexithymia as a predictor of treatment response in post-traumatic stress disorder. Journal Of Traumatic Stress 1992, 5: 563-573. DOI: 10.1007/bf00979225.
- Kosten T, Krystal J, Giller E, Frank J, Dan E. Alexithymia as a predictor of treatment response in post‐traumatic stress disorder. Journal Of Traumatic Stress 1992, 5: 563-573. DOI: 10.1002/jts.2490050406.
- Charney DS, Woods SW, Krystal JH, Nagy LM, Heninger GR. Noradrenergic neuronal dysregulation in panic disorder: the effects of intravenous yohimbine and clonidine in panic disorder patients. Acta Psychiatrica Scandinavica 1992, 86: 273-282. PMID: 1333719, DOI: 10.1111/j.1600-0447.1992.tb03266.x.
- Krystal J, McDougle C, Woods S, Price L, Heninger G, Charney D. Dose-response relationship for oral idazoxan effects in healthy human subjects: comparison with oral yohimbine. Psychopharmacology 1992, 108: 313-319. PMID: 1355923, DOI: 10.1007/bf02245117.
- Seibyl J, Brenner L, Krystal J, Johnson R, Charney D. Mazindol and cocaine addiction in schizophrenia. Biological Psychiatry 1992, 31: 1179-1181. PMID: 1525287, DOI: 10.1016/0006-3223(92)90171-u.
- KARPER L, SEIBYL J, KRYSTAL J. Valproate Management of Psychosis in a Patient with Carbamazepine-Induced Hyponatremia. Journal Of Clinical Psychopharmacology 1992, 12: 137-138. PMID: 1573038, DOI: 10.1097/00004714-199204000-00015.
- WOODS S, NAGY L, KOLESZAR A, KRYSTAL J, HENINGER G, CHAEY D. Controlled Trial of Alprazolam Supplementation During Imipramine Treatment of Panic Disorder. Current Opinion In Cardiology 1992, 7: 32. DOI: 10.1097/00001573-199202000-00006.
- WOODS S, NAGY L, KOLESZAR A, KRYSTAL J, HENINGER G, CHARNEY D. Controlled Trial of Alprazolam Supplementation During Imipramine Treatment of Panic Disorder. Journal Of Clinical Psychopharmacology 1992, 12: 32-38. PMID: 1552038, DOI: 10.1097/00004714-199202000-00006.
- Krystal J. Novel Antipsychotic Drugs. The Yale Journal Of Biology And Medicine 1992, 65: 539-540. PMCID: PMC2589751.
- Krystal J. Trauma and the Vietnam War Generation. The Yale Journal Of Biology And Medicine 1992, 65: 543-544. PMCID: PMC2589725.
- Krystal J, McDougle C, Kosten T, Price L, Aghajanian G, Charney D. Baclofen-assisted detoxification from opiates A pilot study. Journal Of Substance Use And Addiction Treatment 1992, 9: 139-142. PMID: 1324986, DOI: 10.1016/0740-5472(92)90081-x.
- Krystal J, Price L, Opsahl C, Ricaurte G, Heninger G. Chronic 3,4-Methylenedioxymethamphetamine (MDMA) Use: Effects on Mood and Neuropsychological Function? The American Journal Of Drug And Alcohol Abuse 1992, 18: 331-341. PMID: 1357957, DOI: 10.3109/00952999209026070.
- Krystal J. Invited commentary: complexities in evaluating neurobiological models for stress resistance. Journal Of Psychopharmacology 1992, 6: 12-14. PMID: 22291236, DOI: 10.1177/026988119200600105.
- Krystal JH, Leaf PJ, Bruce ML, Charney DS. Effects of age and alcoholism on the prevalence of panic disorder. Acta Psychiatrica Scandinavica 1992, 85: 77-82. PMID: 1546554, DOI: 10.1111/j.1600-0447.1992.tb01447.x.
- Rasmussen K, Krystal J, Aghajanian G. Excitatory amino acids and morphine withdrawal: differential effects of central and peripheral kynurenic acid administration. Psychopharmacology 1991, 105: 508-512. PMID: 1771218, DOI: 10.1007/bf02244371.
- Satel SL, Price LH, Palumbo JM, McDougle CJ, Krystal JH, Gawin F, Charney DS, Heninger GR, Kleber HD. Clinical phenomenology and neurobiology of cocaine abstinence: a prospective inpatient study. American Journal Of Psychiatry 1991, 148: 1712-1716. PMID: 1957935, DOI: 10.1176/ajp.148.12.1712.
- Krystal J, Woods S, Hill C, Charney D. Characteristics of panic attack subtypes: Assessment of spontaneous panic, situational panic, sleep panic, and limited symptom attacks. Comprehensive Psychiatry 1991, 32: 474-480. PMID: 1778074, DOI: 10.1016/0010-440x(91)90026-9.
- Gelernter J, O'Malley S, Risch N, Kranzler HR, Krystal J, Merikangas K, Kennedy JL, Kidd KK. NO Association Between an Allele at the D2 Dopamine Receptor Gene (DRD2) and Alcoholism. JAMA 1991, 266: 1801-1807. PMID: 1832467, DOI: 10.1001/jama.1991.03470130081033.
- Nagy L, Krystal J, Charney D, Woods S. Follow-up Study of Patients With Panic Disorder-Reply. JAMA Psychiatry 1991, 48: 861-862. DOI: 10.1001/archpsyc.1991.01810330085018.
- Seibyl J, Krystal J, Price L, Woods S, D'Amico C, Heninger G, Charney D. Effects of ritanserin on the behavioral, neuroendocrine, and cardiovascular responses to meta-chlorophenylpiperazine in healthy human subjects. Psychiatry Research 1991, 38: 227-236. PMID: 1754635, DOI: 10.1016/0165-1781(91)90013-f.
- Licinio J, Krystal J, Seibyl J, Altemus M, Charney D. Elevated central levels of interleukin-2 in drug-free schizophrenic patients. Schizophrenia Research 1991, 4: 372. DOI: 10.1016/0920-9964(91)90301-7.
- Krystal J, Seibyl J, Price L, Woods S, Heninger G, Charney D. MCPP effects in schizophrenic patients before and after typical and atypical neuroleptic treatment. Schizophrenia Research 1991, 4: 350. DOI: 10.1016/0920-9964(91)90266-t.
- Deutch A, Moghaddam B, Innis R, Krystal J, Aghajanian G, Bunney B, Charney D. Mechanisms of action of atypical antipsychotic drugs Implications for novel therapeutic strategies for schizophrenia. Schizophrenia Research 1991, 4: 121-156. PMID: 1674882, DOI: 10.1016/0920-9964(91)90030-u.
- Woods S, Charney D, Silver J, Krystal J, Heninger G. Behavioral, biochemical, and cardiovascular responses to the benzodiazepine receptor antagonist flumazenil in panic disorder. Psychiatry Research 1991, 36: 115-127. PMID: 1850142, DOI: 10.1016/0165-1781(91)90124-8.
- Woods SW, Hegeman IM, Zubal IG, Krystal JH, Koster K, Smith EO, Heninger GR, Hoffer PB. Visual stimulation increases technetium-99m-HMPAO distribution in human visual cortex. Journal Of Nuclear Medicine 1991, 32: 210-5. PMID: 1992020.
- Woods S, O'malley S, Martini B, Mcdougle C, Price L, Krystal J, Hoffer P, Kosten T. Spect regional cerebral blood flow and neuropsychological testing in non-demented HIV-positive drug abusers: Preliminary results. Progress In Neuro-Psychopharmacology And Biological Psychiatry 1991, 15: 649-662. PMID: 1956993, DOI: 10.1016/0278-5846(91)90055-6.
- Delgado PL, Price LH, Miller HL, Salomon RM, Licinio J, Krystal JH, Heninger GR, Charney DS. Rapid serotonin depletion as a provocative challenge test for patients with major depression: relevance to antidepressant action and the neurobiology of depression. Psychopharmacology Bulletin 1991, 27: 321-30. PMID: 1775606.
- Charney DS, Woods SW, Nagy LM, Southwick SM, Krystal JH, Heninger GR. Noradrenergic function in panic disorder. The Journal Of Clinical Psychiatry 1990, 51 Suppl A: 5-11. PMID: 2258377.
- CHARNEY D, WOODS S, KRYSTAL J, HENINGER G. Serotonin Function and Human Anxiety Disordersa. Annals Of The New York Academy Of Sciences 1990, 600: 558-572. PMID: 2252335, DOI: 10.1111/j.1749-6632.1990.tb16910.x.
- Charney D, Krystal J, Southwick S, Nagy L, Woods S, Heninger G. Serotonin Function in Panic and Generalized Anxiety Disorders. Psychiatric Annals 1990, 20: 593-602. DOI: 10.3928/0048-5713-19901001-11.
- Rasmussen K, Beitner-Johnson D, Krystal J, Aghajanian G, Nestler E. Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates. Journal Of Neuroscience 1990, 10: 2308-2317. PMID: 2115910, PMCID: PMC6570391, DOI: 10.1523/jneurosci.10-07-02308.1990.
- Goodman WK, Price LH, Delgado PL, Palumbo J, Krystal JH, Nagy LM, Rasmussen SA, Heninger GR, Charney DS. Specificity of Serotonin Reuptake Inhibitors in the Treatment of Obsessive-Compulsive Disorder: Comparison of Fluvoxamine and Desipramine. JAMA Psychiatry 1990, 47: 577-585. PMID: 2112374, DOI: 10.1001/archpsyc.1990.01810180077011.
- Charney D, Woods S, Krystal J, Heninger G. Neurobiological Mechanisms of Human Anxiety. Progress In Basic And Clinical Pharmacology 1990, 3: 242-283. DOI: 10.1159/000417680.
- McDougle CJ, Goodman WK, Price LH, Delgado PL, Krystal JH, Charney DS, Heninger GR. Neuroleptic addition in fluvoxamine-refractory obsessive-compulsive disorder. American Journal Of Psychiatry 1990, 147: 652-654. PMID: 1970224, DOI: 10.1176/ajp.147.5.652.
- Price LH, Charney DS, Delgado PL, Goodman WK, Krystal JH, Woods SW, Heninger GR. Clinical data on the role of serotonin in the mechanism(s) of action of antidepressant drugs. The Journal Of Clinical Psychiatry 1990, 51 Suppl: 44-50; discussion 51-2. PMID: 2182616.
- Price L, Krystal J, Heninger G, Ricaurte G. Second Thoughts on 3,4-Methylenedioxymethamphetamine (MDMA) Neurotoxicity-Reply. JAMA Psychiatry 1990, 47: 289-289. DOI: 10.1001/archpsyc.1990.01810150089015.
- Kosten T, Krystal J, Charney D, Price L, Morgan C, Kleber H. Opioid antagonist challenges in buprenorphine maintained patients. Drug And Alcohol Dependence 1990, 25: 73-78. PMID: 2323312, DOI: 10.1016/0376-8716(90)90144-4.
- SEIBYL J, KRYSTAL J, CHARNEY D. Marijuana (cannabis) use is anecdotally said to precipitate anxiety symptoms in patients with panic disorder. Is there any research evidence to support this? Also, can marijuana use precipitate or expose paranoia in patients with an underlying bipolar disorder? Journal Of Clinical Psychopharmacology 1990, 10: 78. PMID: 2307743, DOI: 10.1097/00004714-199002000-00033.
- Charney DS, Krystal JH, Delgado PL, Heninger GR. Serotonin-Specific Drugs for Anxiety and Depressive Disorders. Annual Review Of Medicine 1990, 41: 437-446. PMID: 2139556, DOI: 10.1146/annurev.me.41.020190.002253.
- Price L, Charney D, Delgado P, Goodman W, Krystal J, Woods S, Heninger G. Clinical studies of 5-HT function using I.V. l-Tryptophan. Progress In Neuro-Psychopharmacology And Biological Psychiatry 1990, 14: 459-472. PMID: 2236580, DOI: 10.1016/0278-5846(90)90002-x.
- Nagy LM, Krystal JH, Woods SW, Charney DS. Clinical and Medication Outcome After Short-term Alprazolam and Behavorial Group Treatment in Panic Disorder: 2.5-Year Naturalistic Follow-up Study. JAMA Psychiatry 1989, 46: 993-999. PMID: 2818144, DOI: 10.1001/archpsyc.1989.01810110035005.
- Kosten TR, Krystal JH, Charney DS, Price LH, Morgan CH, Kleber HD. Rapid detoxification from opioid dependence. American Journal Of Psychiatry 1989, 146: 1349a-1349. PMID: 2675644, DOI: 10.1176/ajp.146.10.1349a.
- Woods S, Hegeman I, Krystal J, Smith E, Zubal I, Koster K, Hotfer P. EFFECTS OF VISUAL STIMULATION ON DISTRIBUTION OF TC-99M D, 1 HMPAO IN HEALTHY HUMAN SUBJECTS. Clinical Nuclear Medicine 1989, 14: 230. DOI: 10.1097/00003072-198903000-00025.
- Koster K, Woods S, Smith E, Zubal I, Krystal J, Charney D, Hoffer P. REGIONAL CEREBRAL BLOOD FLOW CHANGES IN PATIENTS WITH PANIC DISORDER. Clinical Nuclear Medicine 1989, 14: 234. DOI: 10.1097/00003072-198903000-00039.
- Krystal J, Walker M, Heninger G. Intermittent naloxone attenuates the development of physical dependence on methadone in rhesus monkeys. European Journal Of Pharmacology 1989, 160: 331-338. PMID: 2540995, DOI: 10.1016/0014-2999(89)90088-5.
- SEIBYL J, KRYSTAL J, PRICE L, CHARNEY D. Use of Yohimbine to Counteract Nortriptyline-Induced Orthostatic Hypotension. Journal Of Clinical Psychopharmacology 1989, 9: 67-68. PMID: 2708559, DOI: 10.1097/00004714-198902000-00026.
- Krystal J, Kosten T, Southwick S, Mason J, Perry B, Giller E. Neurobiological aspects of PTSD: Review of clinical and preclinical studies. Behavior Therapy 1989, 20: 177-198. DOI: 10.1016/s0005-7894(89)80068-1.
- Krystal J. Psychopharmacology: The Third Generation of Progress. The Yale Journal Of Biology And Medicine 1989, 62: 554-555. PMCID: PMC2589180.
- Woods S, Krystal J, Heninger G, Charney D. Effects of alprazolam and clonidine on carbon dioxide-induced increases in anxiety ratings in healthy human subjects. Life Sciences 1989, 45: 233-242. PMID: 2503670, DOI: 10.1016/0024-3205(89)90255-5.
- Krystal J, Woods S, Levesque M, Heninger C, Heninger G. The effects of carbon dioxide inhalation of plasma MHPG, plasma hormones respiratory rate, and behavior in the Rhesus monkey. Life Sciences 1989, 45: 1657-1663. PMID: 2511388, DOI: 10.1016/0024-3205(89)90275-0.
- Price LH, Ricaurte GA, Krystal JH, Heninger GR. Responses to i.v. L-tryptophan in MDMA users. NIDA Research Monograph 1989, 95: 421-2. PMID: 2577044.
- Price LH, Ricaurte GA, Krystal JH, Heninger GR. Neuroendocrine and Mood Responses to Intravenous L-Tryptophan in 3,4-Methylenedioxymethamphetamine (MDMA) Users: Preliminary Observations. JAMA Psychiatry 1989, 46: 20-22. PMID: 2562914, DOI: 10.1001/archpsyc.1989.01810010022003.
- Woods SW, Koster K, Krystal JK, Smith EO, Zubal IG, Hoffer PB, Charney DS. YOHIMBINE ALTERS REGIONAL CEREBRAL BLOOD FLOW IN PANIC DISORDER. The Lancet 1988, 332: 678. PMID: 2901529, DOI: 10.1016/s0140-6736(88)90484-9.
- Krystal J. Neural Plasticity. A Lifespan Approach. The Yale Journal Of Biology And Medicine 1988, 61: 478-479. PMCID: PMC2590436.
- Woods SW, Krystal JH, D'Amico CL, Heninger GR, Charney DS. A review of behavioral and pharmacologic studies relevant to the application of CO2 as a human subject model of anxiety. Psychopharmacology Bulletin 1988, 24: 149-53. PMID: 3133718.
- Kosten T, Krystal J. Biological Mechanisms in Posttraumatic Stress Disorder Relevance for Substance Abuse. Recent Developments In Alcoholism 1988, 6: 49-68. PMID: 3283864, DOI: 10.1007/978-1-4615-7718-8_3.
- Krystal J. Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and Heart. The Yale Journal Of Biology And Medicine 1987, 60: 202-202. PMCID: PMC2590308.
- Krystal J. Quantitative Receptor Autoradiography. The Yale Journal Of Biology And Medicine 1987, 60: 294-295. PMCID: PMC2590106.
- Krystal J. The Psychopharmacology of Lithium. The Yale Journal Of Biology And Medicine 1986, 59: 74-75. PMCID: PMC2590046.
- Krystal H. Management of alcohol withdrawal in the critically ill patient: a selected review. Henry Ford Hospital Medical Journal 1986, 34: 293. PMID: 3583798.
- Krystal JH, Giller EL, Cicchetti DV. Assessment of alexithymia in posttraumatic stress disorder and somatic illness: introduction of a reliable measure. Psychosomatic Medicine 1986, 48: 84-94. PMID: 3945719, DOI: 10.1097/00006842-198601000-00007.
- van der Kolk B, Greenberg M, Boyd H, Krystal J. Inescapable shock, neurotransmitters, and addiction to trauma: Toward a psychobiology of post traumatic stress. Biological Psychiatry 1985, 20: 314-325. PMID: 2858226, DOI: 10.1016/0006-3223(85)90061-7.
- Krystal J. Behavioral Pharmacology: The Current Status. The Yale Journal Of Biology And Medicine 1985, 58: 197-198. PMCID: PMC2589892.
- Krystal J. Monoamine Innervation of the Cerebral Cortex. The Yale Journal Of Biology And Medicine 1985, 58: 58-59. PMCID: PMC2589842.
- Redmond DE, Krystal JH. Multiple Mechanisms of withdrawal from Opioid Drugs. Annual Review Of Neuroscience 1984, 7: 443-478. PMID: 6324646, DOI: 10.1146/annurev.ne.07.030184.002303.
- Krystal J. Physiology of Adrenocortical Secretion. Frontiers of Hormone Research. Volume 11. The Yale Journal Of Biology And Medicine 1984, 57: 247-247. PMCID: PMC2589820.
- Krystal J. Anorexia Nervosa: Recent Developments in Research. The Yale Journal Of Biology And Medicine 1984, 57: 442-443. PMCID: PMC2589855.
- Krystal J. Ethopharmacology: Primate Models of Neuropsychiatric Disorders. The Yale Journal Of Biology And Medicine 1984, 57: 248-250. PMCID: PMC2589821.
- Fassler D, Krystal J. The role of medical student societies in psychiatric recruitment. American Journal Of Psychiatry 1983, 140: 654a-654. PMID: 6846610, DOI: 10.1176/ajp.140.5.654a.
- Krystal JH, Redmond DE. A preliminary description of acute physical dependence on morphine in the vervet monkey. Pharmacology Biochemistry And Behavior 1983, 18: 289-291. PMID: 6682230, DOI: 10.1016/0091-3057(83)90379-9.
- Krystal J. The Natural History of Alcoholism: Causes, Patterns, and Paths to Recovery. The Yale Journal Of Biology And Medicine 1983, 56: 339-340. PMCID: PMC2589638.
- Krystal J, Arnold R. Psychopharmacology of Clonidine. The Yale Journal Of Biology And Medicine 1982, 55: 543-544. PMCID: PMC2596571.
- Krystal H. Trauma: considerations of its intensity and chronicity. International Psychiatry Clinics 1971, 8: 11-28. PMID: 5148247.
Departments and Programs
Biography
John Krystal, MD, is a leading expert in the areas of alcoholism, post-traumatic stress disorder, schizophrenia, and depression. His work links psychopharmacology, neuroimaging, molecular genetics, and computational neuroscience to study the neurobiology and treatment of these disorders. He is best known for leading the discovery of the rapid antidepressant effects of ketamine in depressed patients.
He is a member of the U.S. National Academy of Medicine. He also serves in a variety of advisory and review capacities for NIAAA, NIMH, Wellcome Trust, Brain and Behavior Research Foundation, the Broad Institute, and the Karolinska Institutet.
Dr. Krystal previously served on the National Alcohol Abuse and Alcoholism Advisory Council (NIAAA), the Department of Defense Psychological Health Advisory Committee, and the NIMH Board of Scientific Counselors (chair, 2005-2007). He has led the American College of Neuropsychopharmacology (president, 2012), and International College of Neuropsychophamacology (president, 2016-2018).
Currently, he is co-chair of the Neuroscience Forum (NeuroForum) of the National Academies of Sciences, Engineering, and Medicine, a member of the NIMH National Mental Health Advisory Council, and he edits the journal, Biological Psychiatry (impact factor: 11.982).
Titles
- Robert L. McNeil, Jr. Professor of Translational Research and Professor of Psychiatry, of Neuroscience, and of Psychology
- Co-Director, Yale Center for Clinical Investigation
- Chair, Psychiatry
- Physician-in-Chief of Psychiatry, Yale New Haven Hospital
- Director: NIAAA Center for the Translational Neuroscience of Alcoholism
- Director, Clinical Neuroscience Division, VA National Center for PTSD
Education & Training
- ResidencyYale University School of Medicine (1988)
- MDYale University (1984)
- BAUniversity of Chicago, Behavioral Sciences (1980)
Additional Information
Honors & Recognitions
- Barbara Fish Memorial Award for Contributions to Basic, Translational, and Clinical Neuroscience: American College of Neuropsychopharmacology (2024)
- Rhoda and Bernard Sarnat in International Mental Health Award: National Academy of Medicine (USA) (2023)
- Nasrallah Family Award for Psychiatric Neuroscience: American Psychiatric Association (2023)
- Sir John Gaddam Memorial Lecture and Medal: British Pharmacologic Society (2022)
- Colvin Prize for Outstanding Achievement in Mood Disorders Research: Brain and Behavior Research Foundation (2019)
- Ulf van Euler Memorial Lecturer: Karolinska Institute (2019)
- Edward H. Ahrens, Jr., Distinguished Investigator Award: Association for Clinical and Translational Science (2019)
- E.M. Jellinek Award for Alcohol Research: E.M. Jellinek Foundation (2016)
- Henri Begleiter Award for Research Excellence: Research Society on Alcoholism (2015)
- Paul Hoch Research Award: American Psychopathological Association (2014)
Board Certifications
- AB of Psychiatry & Neurology, Psychiatry (1991)
Professional Service
- Neuroscience Forum, National Academies of Sciences, Engineering, and Medicine (2018 - Present): Co-Director
- International College of Neuropsychopharmacology (2016 - 2018): President
- NIMH (2016 - Present): NIMH National Mental Health Advisory Council
- American College of Neuropsychopharmacology (2011 - 2012): President
Publications
- Harpaz-Rotem *, Duek O, Korem N, Krystal J. MEMORY RELATED STRUCTURAL AND FUNCTIONAL NEURAL CHANGES FOLLOWING A SINGLE INFUSION OF KETAMINE IN PTSD. The International Journal Of Neuropsychopharmacology 2025, 28: i38-i38. PMCID: PMC11814760, DOI: 10.1093/ijnp/pyae059.066.
- Roach B, Ford J, Nicholas S, Ferri J, Gunduz-Bruce H, Krystal J, Jaeger J, Mathalon D. Gamma oscillations and excitation/inhibition imbalance: parallel effects of N-methyl D-aspartate receptor antagonism and psychosis. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 39832734, DOI: 10.1016/j.bpsc.2025.01.008.
- Wolfgang A, Fonzo G, Gray J, Krystal J, Grzenda A, Widge A, Kraguljac N, McDonald W, Rodriguez C, Nemeroff C. MDMA and MDMA-Assisted Therapy. American Journal Of Psychiatry 2024, 182: 79-103. PMID: 39741438, DOI: 10.1176/appi.ajp.20230681.
- Fonzo G, Wolfgang A, Barksdale B, Krystal J, Carpenter L, Kraguljac N, Grzenda A, McDonald W, Widge A, Rodriguez C, Nemeroff C. Psilocybin: From Psychiatric Pariah to Perceived Panacea. American Journal Of Psychiatry 2024, 182: 54-78. PMID: 39741437, PMCID: PMC11694823, DOI: 10.1176/appi.ajp.20230682.
- Fischer I, Na P, Nagamatsu S, Jeste D, Cabrera-Mendoza B, Montalvo-Ortiz J, Krystal J, Polimanti R, Gelernter J, Pietrzak R. Posttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans. JAMA Psychiatry 2024, 81: 1276-1277. PMID: 39476130, PMCID: PMC11581715, DOI: 10.1001/jamapsychiatry.2024.3403.
- Clark S, Hartwell E, Choi D, Krystal J, Messing R, Ferguson L. Next‐generation biomarkers for alcohol consumption and alcohol use disorder diagnosis, prognosis, and treatment: A critical review. Alcohol Clinical And Experimental Research 2024, 49: 5-24. PMID: 39532676, PMCID: PMC11747793, DOI: 10.1111/acer.15476.
- Lamsam L, Gu B, Liang M, Sun G, Khan K, Sheth K, Hirsch L, Pittenger C, Kaye A, Krystal J, Damisah E. The human claustrum tracks slow waves during sleep. Nature Communications 2024, 15: 8964. PMID: 39419999, PMCID: PMC11487173, DOI: 10.1038/s41467-024-53477-x.
- Lee K, Ji J, Fonteneau C, Berkovitch L, Rahmati M, Pan L, Repovš G, Krystal J, Murray J, Anticevic A. Human brain state dynamics are highly reproducible and associated with neural and behavioral features. PLOS Biology 2024, 22: e3002808. PMID: 39316635, PMCID: PMC11421804, DOI: 10.1371/journal.pbio.3002808.
- Ekhtiari H, Zare-Bidoky M, Sangchooli A, Valyan A, Abi-Dargham A, Cannon D, Carter C, Garavan H, George T, Ghobadi-Azbari P, Juchem C, Krystal J, Nichols T, Öngür D, Pernet C, Poldrack R, Thompson P, Paulus M. Reporting checklists in neuroimaging: promoting transparency, replicability, and reproducibility. Neuropsychopharmacology 2024, 50: 67-84. PMID: 39242922, PMCID: PMC11525976, DOI: 10.1038/s41386-024-01973-5.
- Blithikioti C, Duek O, Gordon C, Krystal J, Levy I, Harpaz-Rotem I, Schiller D, Perl O. Cerebellar Contributions to Traumatic Autobiographical Memory in People with Post-Traumatic Stress Disorder. The Cerebellum 2024, 23: 2332-2340. PMID: 39180693, DOI: 10.1007/s12311-024-01731-9.
- Bonomi R, Hillmer A, Woodcock E, Bhatt S, Rusowicz A, Angarita G, Carson R, Davis M, Esterlis I, Nabulsi N, Huang Y, Krystal J, Pietrzak R, Cosgrove K. Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406005121. PMID: 39172786, PMCID: PMC11363315, DOI: 10.1073/pnas.2406005121.
- Petrakis I, Nolen T, Vandergrift N, Hirsch S, Krystal J, De Vivo M, Sabados J, Pisani E, Newcomb J, Kosten T. Dexmedetomidine HCL (BXCL501) as a potential treatment for alcohol use disorder and comorbid PTSD: A phase 1b, placebo‐controlled crossover laboratory study. American Journal On Addictions 2024, 34: 7-14. PMID: 39152094, DOI: 10.1111/ajad.13637.
- Swanberg K, Prinsen H, Averill C, Campos L, Kurada A, Krystal J, Petrakis I, Averill L, Rothman D, Abdallah C, Juchem C. Medial prefrontal cortex neurotransmitter abnormalities in posttraumatic stress disorder with and without comorbidity to major depression. NMR In Biomedicine 2024, 37: e5220. PMID: 39054694, DOI: 10.1002/nbm.5220.
- Averill C, Averill L, Akiki T, Fouda S, Krystal J, Abdallah C. Findings of PTSD-specific deficits in default mode network strength following a mild experimental stressor. NPP—Digital Psychiatry And Neuroscience 2024, 2: 9. PMID: 38919723, PMCID: PMC11197271, DOI: 10.1038/s44277-024-00011-y.
- Blahova Z, Ikezawa S, Falkai P, Krystal J, Rangan T. CONNEX, a Phase III Randomized Trial Program Assessing Efficacy and Safety of Iclepertin in Schizophrenia: Recruitment and Baseline Characteristics. BJPsych Open 2024, 10: s72-s73. PMCID: PMC11738127, DOI: 10.1192/bjo.2024.230.
- Kraguljac N, Bruns D, Appelbaum P, Botello E, King V, Remiszewski N, Widge A, Alpert J, Carpenter L, Grzenda A, Krystal J, McDonald W, Nemeroff C. Post-Roe v Wade psychiatry: legal, clinical, and ethical challenges in psychiatry under abortion bans. The Lancet Psychiatry 2024, 11: 853-862. PMID: 38795722, DOI: 10.1016/s2215-0366(24)00096-8.
- Nunez-Rios D, Hurd Y, Rompala G, Nagamatsu S, Martinez-Magaña J, Krystal J, Group T, Montalvo-Ortiz J. Multi-Omics Mapping in Human Cortical Neurons Reveals Well-Known and Novel Loci of Post-Traumatic Stress Disorder. Biological Psychiatry 2024, 95: s34. DOI: 10.1016/j.biopsych.2024.02.087.
- Martinez-Magaña J, Nagamatsu S, Nunez-Rios D, Krystal J, Girgenti M, Group T, Montalvo-Ortiz J. The Prefrontal Cortex Transcriptomic Landscape of the Comorbidity Between Post-Traumatic Stress Disorder and Opioid Misuse. Biological Psychiatry 2024, 95: s69. DOI: 10.1016/j.biopsych.2024.02.169.
- Moujaes F, Ji J, Rahmati M, Burt J, Schleifer C, Adkinson B, Savic A, Santamauro N, Tamayo Z, Diehl C, Kolobaric A, Flynn M, Rieser N, Fonteneau C, Camarro T, Xu J, Cho Y, Repovs G, Fineberg S, Morgan P, Seifritz E, Vollenweider F, Krystal J, Murray J, Preller K, Anticevic A. Ketamine induces multiple individually distinct whole-brain functional connectivity signatures. ELife 2024, 13: e84173. PMID: 38629811, PMCID: PMC11023699, DOI: 10.7554/elife.84173.
- Na P, Petrakis I, Krystal J, Pietrzak R. Problem Opioid Use Among US Military Veterans: Prevalence, Correlates, and Psychiatric Characteristics. Journal Of Addiction Medicine 2024, 18: 313-318. PMID: 38498625, PMCID: PMC11150085, DOI: 10.1097/adm.0000000000001286.
- Havlik J, Wahid S, Teopiz K, McIntyre R, Krystal J, Rhee T. Recent Advances in the Treatment of Treatment-Resistant Depression: A Narrative Review of Literature Published from 2018 to 2023. Current Psychiatry Reports 2024, 26: 176-213. PMID: 38386251, DOI: 10.1007/s11920-024-01494-4.
- Basu A, Yang J, Yu A, Glaeser-Khan S, Rondeau J, Feng J, Krystal J, Li Y, Kaye A. Frontal Norepinephrine Represents a Threat Prediction Error Under Uncertainty. Biological Psychiatry 2024, 96: 256-267. PMID: 38316333, PMCID: PMC11269024, DOI: 10.1016/j.biopsych.2024.01.025.
- Chekroud A, Hawrilenko M, Loho H, Bondar J, Gueorguieva R, Hasan A, Kambeitz J, Corlett P, Koutsouleris N, Krumholz H, Krystal J, Paulus M. Illusory generalizability of clinical prediction models. Science 2024, 383: 164-167. PMID: 38207039, DOI: 10.1126/science.adg8538.
- Huggins A, Baird C, Briggs M, Laskowitz S, Hussain A, Fouda S, Haswell C, Sun D, Salminen L, Jahanshad N, Thomopoulos S, Veltman D, Frijling J, Olff M, van Zuiden M, Koch S, Nawjin L, Wang L, Zhu Y, Li G, Stein D, Ipser J, Seedat S, du Plessis S, van den Heuvel L, Suarez-Jimenez B, Zhu X, Kim Y, He X, Zilcha-Mano S, Lazarov A, Neria Y, Stevens J, Ressler K, Jovanovic T, van Rooij S, Fani N, Hudson A, Mueller S, Sierk A, Manthey A, Walter H, Daniels J, Schmahl C, Herzog J, Říha P, Rektor I, Lebois L, Kaufman M, Olson E, Baker J, Rosso I, King A, Liberzon I, Angstadt M, Davenport N, Sponheim S, Disner S, Straube T, Hofmann D, Qi R, Lu G, Baugh L, Forster G, Simons R, Simons J, Magnotta V, Fercho K, Maron-Katz A, Etkin A, Cotton A, O’Leary E, Xie H, Wang X, Quidé Y, El-Hage W, Lissek S, Berg H, Bruce S, Cisler J, Ross M, Herringa R, Grupe D, Nitschke J, Davidson R, Larson C, deRoon-Cassini T, Tomas C, Fitzgerald J, Blackford J, Olatunji B, Kremen W, Lyons M, Franz C, Gordon E, May G, Nelson S, Abdallah C, Levy I, Harpaz-Rotem I, Krystal J, Dennis E, Tate D, Cifu D, Walker W, Wilde E, Harding I, Kerestes R, Thompson P, Morey R. Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup. Molecular Psychiatry 2024, 29: 611-623. PMID: 38195980, PMCID: PMC11153161, DOI: 10.1038/s41380-023-02352-0.
- Tamman A, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal J, Gelernter J, Montalvo-Ortiz J, Polimanti R, Pietrzak R. Correction: Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Neuropsychopharmacology 2024, 49: 764-764. PMID: 38182778, PMCID: PMC10876612, DOI: 10.1038/s41386-023-01786-y.
- Krystal J, Imeh I, Garces R, Addy N. The Biological Psychiatry Cover Art Initiative: Addressing the Underrepresentation of Black People on the Journal Cover Through a Series of Commissioned Artworks. Biological Psychiatry 2024, 95: 2. PMID: 38030306, DOI: 10.1016/j.biopsych.2023.10.010.
- Zhou H, Kember R, Deak J, Xu H, Toikumo S, Yuan K, Lind P, Farajzadeh L, Wang L, Hatoum A, Johnson J, Lee H, Mallard T, Xu J, Johnston K, Johnson E, Nielsen T, Galimberti M, Dao C, Levey D, Overstreet C, Byrne E, Gillespie N, Gordon S, Hickie I, Whitfield J, Xu K, Zhao H, Huckins L, Davis L, Sanchez-Roige S, Madden P, Heath A, Medland S, Martin N, Ge T, Smoller J, Hougaard D, Børglum A, Demontis D, Krystal J, Gaziano J, Edenberg H, Agrawal A, Justice A, Stein M, Kranzler H, Gelernter J. Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals. Nature Medicine 2023, 29: 3184-3192. PMID: 38062264, PMCID: PMC10719093, DOI: 10.1038/s41591-023-02653-5.
- Perl O, Duek O, Kulkarni K, Gordon C, Krystal J, Levy I, Harpaz-Rotem I, Schiller D. Neural patterns differentiate traumatic from sad autobiographical memories in PTSD. Nature Neuroscience 2023, 26: 2226-2236. PMID: 38036701, DOI: 10.1038/s41593-023-01483-5.
- Yang J, Huggins A, Sun D, Baird C, Haswell C, Frijling J, Olff M, van Zuiden M, Koch S, Nawijn L, Veltman D, Suarez-Jimenez B, Zhu X, Neria Y, Hudson A, Mueller S, Baker J, Lebois L, Kaufman M, Qi R, Lu G, Říha P, Rektor I, Dennis E, Ching C, Thomopoulos S, Salminen L, Jahanshad N, Thompson P, Stein D, Koopowitz S, Ipser J, Seedat S, du Plessis S, van den Heuvel L, Wang L, Zhu Y, Li G, Sierk A, Manthey A, Walter H, Daniels J, Schmahl C, Herzog J, Liberzon I, King A, Angstadt M, Davenport N, Sponheim S, Disner S, Straube T, Hofmann D, Grupe D, Nitschke J, Davidson R, Larson C, deRoon-Cassini T, Blackford J, Olatunji B, Gordon E, May G, Nelson S, Abdallah C, Levy I, Harpaz-Rotem I, Krystal J, Morey R, Sotiras A. Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods. Neuropsychopharmacology 2023, 49: 609-619. PMID: 38017161, PMCID: PMC10789873, DOI: 10.1038/s41386-023-01763-5.
- Krystal J, Kaye A, Jefferson S, Girgenti M, Wilkinson S, Sanacora G, Esterlis I. Ketamine and the neurobiology of depression: Toward next-generation rapid-acting antidepressant treatments. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2305772120. PMID: 38011560, PMCID: PMC10710048, DOI: 10.1073/pnas.2305772120.
- Ward E, Fragala M, Birse C, Hawrilenko M, Smolka C, Ambwani G, Brown M, Krystal J, Corlett P, Chekroud A. Assessing the impact of a comprehensive mental health program on frontline health service workers. PLOS ONE 2023, 18: e0294414. PMID: 37988363, PMCID: PMC10662717, DOI: 10.1371/journal.pone.0294414.
- Zhu X, Kim Y, Ravid O, He X, Suarez-Jimenez B, Zilcha-Mano S, Lazarov A, Lee S, Abdallah C, Angstadt M, Averill C, Baird C, Baugh L, Blackford J, Bomyea J, Bruce S, Bryant R, Cao Z, Choi K, Cisler J, Cotton A, Daniels J, Davenport N, Davidson R, DeBellis M, Dennis E, Densmore M, deRoon-Cassini T, Disner S, Hage W, Etkin A, Fani N, Fercho K, Fitzgerald J, Forster G, Frijling J, Geuze E, Gonenc A, Gordon E, Gruber S, Grupe D, Guenette J, Haswell C, Herringa R, Herzog J, Hofmann D, Hosseini B, Hudson A, Huggins A, Ipser J, Jahanshad N, Jia-Richards M, Jovanovic T, Kaufman M, Kennis M, King A, Kinzel P, Koch S, Koerte I, Koopowitz S, Korgaonkar M, Krystal J, Lanius R, Larson C, Lebois L, Li G, Liberzon I, Lu G, Luo Y, Magnotta V, Manthey A, Maron-Katz A, May G, McLaughlin K, Mueller S, Nawijn L, Nelson S, Neufeld R, Nitschke J, O'Leary E, Olatunji B, Olff M, Peverill M, Phan K, Qi R, Quidé Y, Rektor I, Ressler K, Riha P, Ross M, Rosso I, Salminen L, Sambrook K, Schmahl C, Shenton M, Sheridan M, Shih C, Sicorello M, Sierk A, Simmons A, Simons R, Simons J, Sponheim S, Stein M, Stein D, Stevens J, Straube T, Sun D, Théberge J, Thompson P, Thomopoulos S, van der Wee N, van der Werff S, van Erp T, van Rooij S, van Zuiden M, Varkevisser T, Veltman D, Vermeiren R, Walter H, Wang L, Wang X, Weis C, Winternitz S, Xie H, Zhu Y, Wall M, Neria Y, Morey R. Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium. NeuroImage 2023, 283: 120412. PMID: 37858907, PMCID: PMC10842116, DOI: 10.1016/j.neuroimage.2023.120412.
- Tamman A, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal J, Gelernter J, Montalvo-Ortiz J, Polimanti R, Pietrzak R. Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Neuropsychopharmacology 2023, 49: 699-708. PMID: 37848731, PMCID: PMC10876568, DOI: 10.1038/s41386-023-01747-5.
- Krystal J, Preller K, Corlett P, Anticevic A, Kaye A. Psychedelics and the Neurobiology of Meaningfulness. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 9: 462-463. PMID: 37730161, DOI: 10.1016/j.bpsc.2023.09.003.
- Na P, Zhou H, Montalvo-Ortiz J, Cabrera-Mendoza B, Petrakis I, Krystal J, Polimanti R, Gelernter J, Pietrzak R. Positive personality traits moderate persistent high alcohol consumption, determined by polygenic risk in U.S. military veterans: results from a 10-year, population-based, observational cohort study. Psychological Medicine 2023, 53: 7893-7901. PMID: 37642191, PMCID: PMC11750353, DOI: 10.1017/s003329172300199x.
- Rompala G, Nagamatsu S, Martínez-Magaña J, Nuñez-Ríos D, Wang J, Girgenti M, Krystal J, Gelernter J, Hurd Y, Montalvo-Ortiz J. Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex. Nature Communications 2023, 14: 4544. PMID: 37507366, PMCID: PMC10382503, DOI: 10.1038/s41467-023-40285-y.
- Krystal J, Kavalali E, Monteggia L. Ketamine and rapid antidepressant action: new treatments and novel synaptic signaling mechanisms. Neuropsychopharmacology 2023, 49: 41-50. PMID: 37488280, PMCID: PMC10700627, DOI: 10.1038/s41386-023-01629-w.
- Benfer N, Grunthal B, Dondanville K, Young-McCaughan S, Blankenship A, Abdallah C, Back S, Flanagan J, Foa E, Fox P, Krystal J, Marx B, McGeary D, McLean C, Pruiksma K, Resick P, Roache J, Shiroma P, Sloan D, Taylor D, Wachen J, López-Roca A, Nicholson K, Schobitz R, Schrader C, Sharrieff A, Yarvis J, Mintz J, Keane T, Peterson A, Litz B. DSM-5 Criterion-A-Based Trauma Types in Service Members and Veterans Seeking Treatment for Posttraumatic Stress Disorder. Psychological Trauma Theory Research Practice And Policy 2023, 16: 1218-1228. PMID: 37410416, PMCID: PMC10770283, DOI: 10.1037/tra0001537.
- Duek O, Korem N, Li Y, Kelmendi B, Amen S, Gordon C, Milne M, Krystal J, Levy I, Harpaz-Rotem I. Long term structural and functional neural changes following a single infusion of Ketamine in PTSD. Neuropsychopharmacology 2023, 48: 1648-1658. PMID: 37270621, PMCID: PMC10517133, DOI: 10.1038/s41386-023-01606-3.
- Fischer I, Nichter B, Na P, Norman S, Krystal J, Pietrzak R. Longitudinal Trends in Suicidal Thoughts and Behaviors Among US Military Veterans During the COVID-19 Pandemic. JAMA Psychiatry 2023, 80: 577-584. PMID: 37017978, PMCID: PMC10077136, DOI: 10.1001/jamapsychiatry.2023.0393.
- Kaye A, Rao M, Kwan A, Ressler K, Krystal J. A computational model for learning from repeated traumatic experiences under uncertainty. Cognitive, Affective, & Behavioral Neuroscience 2023, 23: 894-904. PMID: 37165181, PMCID: PMC11149767, DOI: 10.3758/s13415-023-01085-5.
- Abi-Dargham A, Moeller S, Ali F, DeLorenzo C, Domschke K, Horga G, Jutla A, Kotov R, Paulus M, Rubio J, Sanacora G, Veenstra-VanderWeele J, Krystal J. Candidate biomarkers in psychiatric disorders: state of the field. World Psychiatry 2023, 22: 236-262. PMID: 37159365, PMCID: PMC10168176, DOI: 10.1002/wps.21078.
- Surti T, Ranganathan M, Johannesen J, Gueorguieva R, Deaso E, Kenney J, Krystal J, D'Souza D. Randomized controlled trial of the glycine transporter 1 inhibitor PF-03463275 to enhance cognitive training and neuroplasticity in schizophrenia. Schizophrenia Research 2023, 256: 36-43. PMID: 37141764, PMCID: PMC10257994, DOI: 10.1016/j.schres.2023.04.010.
- Girgenti M, Zhang J, Skarica M, Hwang A, Xu K, Young K, Zhao H, Sestan N, Krystal J. Single Cell Genomic Analysis Reveals Cell Type-Specific Molecular Signatures in the Human PTSD Prefrontal Cortex. Biological Psychiatry 2023, 93: s11-s12. DOI: 10.1016/j.biopsych.2023.02.049.
- Rahmati M, Moujaes F, Schleifer C, Ji J, Fonteneau C, Tamayo Z, Santamauro N, Respov G, Fineberg S, Krystal J, Murray J, Cho Y, Anticevic A. 248. Effects of NMDA Receptor Antagonist Ketamine on Neural Tuning. Biological Psychiatry 2023, 93: s193-s194. DOI: 10.1016/j.biopsych.2023.02.488.
- Driesen N, Herman P, Rowland M, Thompson G, Qiu M, He G, Criscuolo E, Fineberg S, Barron D, Helgeson L, Lacadie C, Chow R, Gueorguieva R, Straun T, Krystal J, Hyder F. 430. Calibrated fMRI Sensitive to Ketamine-Related Increases Throughout the Cortex. Biological Psychiatry 2023, 93: s268-s269. DOI: 10.1016/j.biopsych.2023.02.670.
- Sarantopoulos C, Shin D, Schleifer C, Moujaes F, Adkinson B, Ji J, Kolabaric A, Flynn M, Santamauro N, Krystal J, Murray J, Repovs G, Martin W, Pittenger C, Anticevic A, Cho Y. 511. Common and Distinct Effects of Incentives on Spatial Working Memory in Schizophrenia and Obsessive-Compulsive Disorder. Biological Psychiatry 2023, 93: s300-s301. DOI: 10.1016/j.biopsych.2023.02.751.
- Johnson T, Black S, Smith B, Krystal J, Sevier B, Aly F, Kumpf B, Grover K, Solod A. 183 Explaining Research to Children and Adolescents. Journal Of Clinical And Translational Science 2023, 7: 56-57. PMCID: PMC10129822, DOI: 10.1017/cts.2023.261.
- Johnson T, Davis J, Smith B, Krystal J, Sevier B, Perry L, Clayton E, Black S. 93 Empowering the Next Generation of Clinical & Translational Scientists. Journal Of Clinical And Translational Science 2023, 7: 26-26. PMCID: PMC10129482, DOI: 10.1017/cts.2023.176.
- Shinn M, Hu A, Turner L, Noble S, Preller K, Ji J, Moujaes F, Achard S, Scheinost D, Constable R, Krystal J, Vollenweider F, Lee D, Anticevic A, Bullmore E, Murray J. Functional brain networks reflect spatial and temporal autocorrelation. Nature Neuroscience 2023, 26: 867-878. PMID: 37095399, DOI: 10.1038/s41593-023-01299-3.
- Widge A, Jordan A, Kraguljac N, Sullivan C, Wilson S, Benton T, Alpert J, Carpenter L, Krystal J, Nemeroff C, Dzirasa K. Structural Racism in Psychiatric Research Careers: Eradicating Barriers to a More Diverse Workforce. American Journal Of Psychiatry 2023, 180: 645-659. PMID: 37073513, PMCID: PMC11227892, DOI: 10.1176/appi.ajp.20220685.
- Wunderlich G, Blahova Z, Hake S, Ikezawa S, Marder S, Falkai P, Krystal J. Efficacy and Safety of Iclepertin (BI 425809) in Patients With Schizophrenia: CONNEX, A Phase III Randomized Controlled Trial Program. CNS Spectrums 2023, 28: 229-229. DOI: 10.1017/s1092852923001530.
- Havlik J, Murphy M, Gong N, Tang D, Krystal J. Characteristics of Esketamine Prescribers Among Medicare Beneficiaries in the United States, 2019-2020. JAMA Network Open 2023, 6: e2311250. PMID: 37103934, PMCID: PMC10140803, DOI: 10.1001/jamanetworkopen.2023.11250.
- Jia R, Ruderman L, Pietrzak R, Gordon C, Ehrlich D, Horvath M, Mirchandani S, DeFontes C, Southwick S, Krystal J, Harpaz-Rotem I, Levy I. Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach. Translational Psychiatry 2023, 13: 101. PMID: 36977676, PMCID: PMC10050320, DOI: 10.1038/s41398-023-02388-4.
- Na P, Montalvo-Ortiz J, Petrakis I, Krystal J, Polimanti R, Gelernter J, Pietrzak R. Trajectories of alcohol consumption in U.S. military veterans: Results from a 10-year population-based longitudinal study. Drug And Alcohol Dependence 2023, 246: 109833. PMID: 36963160, PMCID: PMC10811960, DOI: 10.1016/j.drugalcdep.2023.109833.
- Falkai P, Reuteman-Fowler C, Blahova Z, Ikezawa S, Marder S, Krystal J. Efficacy and safety of iclepertin (BI 425809) in patients with schizophrenia: CONNEX, a Phase III randomised controlled trial programme. European Psychiatry 2023, 66: s637-s637. PMCID: PMC10661489, DOI: 10.1192/j.eurpsy.2023.1325.
- Fineberg S, Choi E, Shapiro-Thompson R, Dhaliwal K, Neustadter E, Sakheim M, Null K, Trujillo-Diaz D, Rondeau J, Pittaro G, Peters J, Corlett P, Krystal J. A pilot randomized controlled trial of ketamine in Borderline Personality Disorder. Neuropsychopharmacology 2023, 48: 991-999. PMID: 36804489, PMCID: PMC10209175, DOI: 10.1038/s41386-023-01540-4.
- Núñez-Rios D, Martínez-Magaña J, Nagamatsu S, Krystal J, Martínez-González K, Giusti-Rodríguez P, Montalvo-Ortiz J. Cross-Species Convergence of Brain Transcriptomic and Epigenomic Findings in Posttraumatic Stress Disorder: A Systematic Review. Complex Psychiatry 2023, 9: 100-118. PMID: 37404872, PMCID: PMC10315001, DOI: 10.1159/000529536.
- Fischer I, Na P, Harpaz-Rotem I, Krystal J, Pietrzak R. Characterization of Mental Health in US Veterans Before, During, and 2 Years After the Onset of the COVID-19 Pandemic. JAMA Network Open 2023, 6: e230463. PMID: 36821116, PMCID: PMC9951035, DOI: 10.1001/jamanetworkopen.2023.0463.
- Nagamatsu S, Rompala G, Hurd Y, Núñez-Rios D, Montalvo-Ortiz J, Group T, Alvarez V, Benedek D, Che A, Cruz D, Davis D, Girgenti M, Hoffman E, Holtzheimer P, Huber B, Kaye A, Krystal J, Labadorf A, Keane T, Logue M, McKee A, Marx B, Mash D, Miller M, Noller C, JM-O, Scott W, Schnurr P, Stein T, Ursano R, Williamson D, Wolf E, Young K. CpH methylome analysis in human cortical neurons identifies novel gene pathways and drug targets for opioid use disorder. Frontiers In Psychiatry 2023, 13: 1078894. PMID: 36745154, PMCID: PMC9892724, DOI: 10.3389/fpsyt.2022.1078894.
- Stanley I, Marx B, Fina B, Young-McCaughan S, Tyler H, Sloan D, Blankenship A, Dondanville K, Walker J, Boffa J, Bryan C, Brown L, Straud C, Mintz J, Abdallah C, Back S, Blount T, DeBeer B, Flanagan J, Foa E, Fox P, Fredman S, Krystal J, McDevitt-Murphy M, McGeary D, Pruiksma K, Resick P, Roache J, Shiroma P, Taylor D, Wachen J, Kaplan A, López-Roca A, Nicholson K, Schobitz R, Schrader C, Sharrieff A, Yarvis J, Litz B, Keane T, Peterson A. Psychometric Properties of the Self-Injurious Thoughts and Behaviors Interview–Short Form Among U.S. Active Duty Military Service Members and Veterans. Assessment 2023, 30: 2332-2346. PMID: 36644835, DOI: 10.1177/10731911221143979.
- Reuteman-Fowler C, Blahova Z, Ikezawa S, Marder S, Falkai P, Krystal J. Efficacy and safety of iclepertin (BI 425809) in patients with schizophrenia: CONNEX, a Phase III randomised controlled trial programme. Neuroscience Applied 2023, 2: 102592. DOI: 10.1016/j.nsa.2023.102592.
- Rhee TG, Shim SR, Forester BP, Nierenberg AA, McIntyre RS, Papakostas GI, Krystal JH, Sanacora G, Wilkinson ST. Efficacy and Safety of Ketamine vs Electroconvulsive Therapy Among Patients With Major Depressive Episode. JAMA Psychiatry 2022, 79: 1162-1172. PMID: 36260324, PMCID: PMC9582972, DOI: 10.1001/jamapsychiatry.2022.3352.
- Krystal J, Kane J, Correll C, Walling D, Leoni M, Duvvuri S, Patel S, Chang I, Iredale P, Frohlich L, Versavel S, Perry P, Sanchez R, Renger J. Emraclidine, a novel positive allosteric modulator of cholinergic M4 receptors, for the treatment of schizophrenia: a two-part, randomised, double-blind, placebo-controlled, phase 1b trial. The Lancet 2022, 400: 2210-2220. PMID: 36528376, DOI: 10.1016/s0140-6736(22)01990-0.
- Nagamatsu S, Pietrzak R, Xu K, Krystal J, Gelernter J, Montalvo‐Ortiz J. Dissecting the epigenomic differences between smoking and nicotine dependence in a veteran cohort. Addiction Biology 2022, 28: e13259. PMID: 36577721, DOI: 10.1111/adb.13259.
- Nichter B, Koller D, De Angelis F, Wang J, Girgenti M, Na P, Hill M, Norman S, Krystal J, Gelernter J, Polimanti R, Pietrzak R. Genetic liability to suicidal thoughts and behaviors and risk of suicide attempt in US military veterans: moderating effects of cumulative trauma burden. Psychological Medicine 2022, 53: 6325-6333. PMID: 36444557, DOI: 10.1017/s0033291722003646.
- Merians A, Spiller T, Harpaz-Rotem I, Krystal J, Pietrzak R. Post-traumatic Stress Disorder. Medical Clinics Of North America 2022, 107: 85-99. PMID: 36402502, DOI: 10.1016/j.mcna.2022.04.003.
- Harvey PD, Depp CA, Rizzo AA, Strauss GP, Spelber D, Carpenter LL, Kalin NH, Krystal JH, McDonald WM, Nemeroff CB, Rodriguez CI, Widge AS, Torous J. Technology and Mental Health: State of the Art for Assessment and Treatment. American Journal Of Psychiatry 2022, 179: 897-914. PMID: 36200275, DOI: 10.1176/appi.ajp.21121254.
- Citrome L, Preskorn SH, Lauriello J, Krystal JH, Kakar R, Finman J, De Vivo M, Yocca FD, Risinger R, Rajachandran L. Sublingual Dexmedetomidine for the Treatment of Acute Agitation in Adults With Schizophrenia or Schizoaffective Disorder: A Randomized Placebo-Controlled Trial. The Journal Of Clinical Psychiatry 2022, 83 PMID: 36198061, DOI: 10.4088/jcp.22m14447.
- Tamman AJF, Nagamatsu S, Krystal JH, Gelernter J, Montalvo-Ortiz JL, Pietrzak RH. Psychosocial Factors Associated With Accelerated GrimAge in Male U.S. Military Veterans. American Journal Of Geriatric Psychiatry 2022, 31: 97-109. PMID: 36210262, DOI: 10.1016/j.jagp.2022.09.002.
- Olson K, Fogelman N, Maturo L, Alvarado J, Ball S, Forray A, Hu M, Ivy M, Kapo J, Krystal J, Mayes L, Rohrbaugh R, Southwick S, Tebes J, Wassel B, Sinha R. COVID-19 Traumatic Disaster Appraisal and Stress Symptoms Among Health Care Workers. Journal Of Occupational And Environmental Medicine 2022, 64: 934-941. PMID: 35959912, PMCID: PMC9640251, DOI: 10.1097/jom.0000000000002673.
- Wendt FR, Pathak GA, Singh K, Stein MB, Koenen KC, Krystal JH, Gelernter J, Davis LK, Polimanti R. Sex-Specific Genetic and Transcriptomic Liability to Neuroticism. Biological Psychiatry 2022, 93: 243-252. PMID: 36244801, PMCID: PMC10508260, DOI: 10.1016/j.biopsych.2022.07.019.
- Jegede O, Na PJ, Haeny AM, Krystal JH, Pietrzak RH. Association of Distress Due to Systemic Racism and Racial Disparities With Psychopathology and Suicidal Ideation Among US Veterans During the COVID-19 Pandemic. The Journal Of Clinical Psychiatry 2022, 83 PMID: 35921504, PMCID: PMC10228546, DOI: 10.4088/jcp.22br14410.
- Sun D, Rakesh G, Haswell CC, Logue M, Baird CL, O'Leary EN, Cotton AS, Xie H, Tamburrino M, Chen T, Dennis EL, Jahanshad N, Salminen LE, Thomopoulos SI, Rashid F, Ching CRK, Koch SBJ, Frijling JL, Nawijn L, van Zuiden M, Zhu X, Suarez-Jimenez B, Sierk A, Walter H, Manthey A, Stevens JS, Fani N, van Rooij SJH, Stein M, Bomyea J, Koerte IK, Choi K, van der Werff SJA, Vermeiren RRJM, Herzog J, Lebois LAM, Baker JT, Olson EA, Straube T, Korgaonkar MS, Andrew E, Zhu Y, Li G, Ipser J, Hudson AR, Peverill M, Sambrook K, Gordon E, Baugh L, Forster G, Simons RM, Simons JS, Magnotta V, Maron-Katz A, du Plessis S, Disner SG, Davenport N, Grupe DW, Nitschke JB, deRoon-Cassini TA, Fitzgerald JM, Krystal JH, Levy I, Olff M, Veltman DJ, Wang L, Neria Y, De Bellis MD, Jovanovic T, Daniels JK, Shenton M, van de Wee NJA, Schmahl C, Kaufman ML, Rosso IM, Sponheim SR, Hofmann DB, Bryant RA, Fercho KA, Stein DJ, Mueller SC, Hosseini B, Phan KL, McLaughlin KA, Davidson RJ, Larson CL, May G, Nelson SM, Abdallah CG, Gomaa H, Etkin A, Seedat S, Harpaz-Rotem I, Liberzon I, van Erp TGM, Quidé Y, Wang X, Thompson PM, Morey RA. A comparison of methods to harmonize cortical thickness measurements across scanners and sites. NeuroImage 2022, 261: 119509. PMID: 35917919, PMCID: PMC9648725, DOI: 10.1016/j.neuroimage.2022.119509.
- Na PJ, Montalvo-Ortiz JL, Nagamatsu ST, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. Association of Symptoms of Posttraumatic Stress Disorder and GrimAge, an Epigenetic Marker of Mortality Risk, in US Military Veterans. The Journal Of Clinical Psychiatry 2022, 83 PMID: 35802930, PMCID: PMC10859885, DOI: 10.4088/jcp.21br14309.
- Kohler C, Wolf D, Abi-Dargham A, Anticevic A, Cho Y, Fonteneau C, Gil R, Girgis R, Gray D, Grinband J, Javitch J, Kantrowitz J, Krystal J, Lieberman J, Murray J, Ranganathan M, Santamauro N, Van Snellenberg J, Tamayo Z, Group T, D'Souza D, Srihari V, Gueorguieva R, Patel P, Forselius-Bielen K, Lu J, Butler A, Fram G, Afriyie-Agyemang Y, Selloni A, Cadavid L, Gomez-Luna S, Gupta A, Radhakrishnan R, Rashid A, Aker R, Abrahim P, Nia A, Surti T, Kegeles L, Carlson M, Goldberg T, Gangwisch J, Benedict E, Govil P, Brazis S, Mayer M, de la Garrigue N, Fallon N, Baumvoll T, Abeykoon S, Perlman G, Bobchin K, Elliott M, Schmidt L, Rush S, Port A, Heffernan Z, Laney N, Kantor J, Hohing T, Gur R, Gur R, Calkins M. Illness Phase as a Key Assessment and Intervention Window for Psychosis. Biological Psychiatry Global Open Science 2022, 3: 340-350. PMID: 37519466, PMCID: PMC10382701, DOI: 10.1016/j.bpsgos.2022.05.009.
- Bondar J, Morrow C, Gueorguieva R, Brown M, Hawrilenko M, Krystal JH, Corlett PR, Chekroud AM. Clinical and Financial Outcomes Associated With a Workplace Mental Health Program Before and During the COVID-19 Pandemic. JAMA Network Open 2022, 5: e2216349. PMID: 35679044, PMCID: PMC9185188, DOI: 10.1001/jamanetworkopen.2022.16349.
- Abdallah CG, Roache JD, Gueorguieva R, Averill LA, Young-McCaughan S, Shiroma PR, Purohit P, Brundige A, Murff W, Ahn KH, Sherif MA, Baltutis EJ, Ranganathan M, D’Souza D, Martini B, Southwick SM, Petrakis IL, Burson RR, Guthmiller KB, López-Roca AL, Lautenschlager KA, McCallin JP, Hoch MB, Timchenko A, Souza SE, Bryant CE, Mintz J, Litz BT, Williamson DE, Keane TM, Peterson AL, Krystal JH. Correction to: Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial. Neuropsychopharmacology 2022, 47: 1583-1584. PMID: 35545665, PMCID: PMC9205895, DOI: 10.1038/s41386-022-01339-9.
- Nagamatsu S, Pietrzak R, Na P, Krystal J, Gelernter J, Montalvo-Ortiz J. P79. Are Positive Psychosocial Traits Linked to Epigenetic Aging? Results From a National Sample of U.S. Military Veterans. Biological Psychiatry 2022, 91: s119. DOI: 10.1016/j.biopsych.2022.02.313.
- Nunez-Rios D, Rompala G, Hurd Y, Nagamatsu S, Martinez-Magaña J, Krystal J, Gelernter J, Montalvo-Ortiz T. P630. Multiomics Mapping of Posttraumatic Stress Disorder in Human Cortical Neurons. Biological Psychiatry 2022, 91: s344. DOI: 10.1016/j.biopsych.2022.02.867.
- Shaikh N, Sandhu M, Aljishi A, Obaid S, Gu B, Krystal J, Kaye A, Damisah E. P142. Neural Correlates of Bodily Feedback During Spatial Threat Avoidance. Biological Psychiatry 2022, 91: s144. DOI: 10.1016/j.biopsych.2022.02.376.
- Aljishi A, Sandhu M, Shaikh N, Wise T, Krystal J, Kaye A, Damisah E. P143. Intracranial Electrophysiology of Amygdala-Insula Interactions in Anxiety. Biological Psychiatry 2022, 91: s144-s145. DOI: 10.1016/j.biopsych.2022.02.377.
- Tebes JK, Awad MN, Connors EH, Fineberg SK, Gordon DM, Jordan A, Kravitz R, Li L, Ponce AN, Prabhu M, Rubman S, Silva MA, Steinfeld M, Tate DC, Xu K, Krystal JH. The Stress and Resilience Town Hall: A systems response to support the health workforce during COVID-19 and beyond. General Hospital Psychiatry 2022, 77: 80-87. PMID: 35569322, PMCID: PMC9033303, DOI: 10.1016/j.genhosppsych.2022.04.009.
- Swanberg K, Prinsen H, Averill C, Campos L, Kurada A, Krystal J, Petrakis I, Averill L, Abdallah C, Juchem C. Abnormal glutamate metabolism in prefrontal cortex of post-traumatic stress disorder linked to comorbidity with major depression. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2022 DOI: 10.58530/2022/3344.
- Smart K, Worhunsky PD, Scheinost D, Angarita GA, Esterlis I, Carson RE, Krystal JH, O'Malley SS, Cosgrove KP, Hillmer AT. Multimodal neuroimaging of metabotropic glutamate 5 receptors and functional connectivity in alcohol use disorder. Alcohol Clinical And Experimental Research 2022, 46: 770-782. PMID: 35342968, PMCID: PMC9117461, DOI: 10.1111/acer.14816.
- Nikayin S, Murphy E, Krystal JH, Wilkinson ST. Long-term safety of ketamine and esketamine in treatment of depression. Expert Opinion On Drug Safety 2022, 21: 777-787. PMID: 35416105, DOI: 10.1080/14740338.2022.2066651.
- Abram SV, Roach BJ, Fryer SL, Calhoun VD, Preda A, van Erp TGM, Bustillo JR, Lim KO, Loewy RL, Stuart BK, Krystal JH, Ford JM, Mathalon DH. Validation of ketamine as a pharmacological model of thalamic dysconnectivity across the illness course of schizophrenia. Molecular Psychiatry 2022, 27: 2448-2456. PMID: 35422467, PMCID: PMC9135621, DOI: 10.1038/s41380-022-01502-0.
- Krystal JH, Southwick SM, Girgenti MJ. Matthew J. Friedman, M.D., Ph.D. and His Legacy of Leadership in the Field of Post-traumatic Stress Disorder. Psychiatry 2022, 85: 161-170. PMID: 35588483, DOI: 10.1080/00332747.2022.2068931.
- Cho YT, Moujaes F, Schleifer CH, Starc M, Ji JL, Santamauro N, Adkinson B, Kolobaric A, Flynn M, Krystal JH, Murray JD, Repovs G, Anticevic A. Reward and loss incentives improve spatial working memory by shaping trial-by-trial posterior frontoparietal signals. NeuroImage 2022, 254: 119139. PMID: 35346841, PMCID: PMC9264479, DOI: 10.1016/j.neuroimage.2022.119139.
- Sun D, Rakesh G, Clarke-Rubright EK, Haswell CC, Logue MW, O'Leary EN, Cotton AS, Xie H, Dennis EL, Jahanshad N, Salminen LE, Thomopoulos SI, Rashid FM, Ching CRK, Koch SBJ, Frijling JL, Nawijn L, van Zuiden M, Zhu X, Suarez-Jimenez B, Sierk A, Walter H, Manthey A, Stevens JS, Fani N, van Rooij SJH, Stein MB, Bomyea J, Koerte I, Choi K, van der Werff SJA, Vermeiren RRJM, Herzog JI, Lebois LAM, Baker JT, Ressler KJ, Olson EA, Straube T, Korgaonkar MS, Andrew E, Zhu Y, Li G, Ipser J, Hudson AR, Peverill M, Sambrook K, Gordon E, Baugh LA, Forster G, Simons RM, Simons JS, Magnotta VA, Maron-Katz A, du Plessis S, Disner SG, Davenport ND, Grupe D, Nitschke JB, deRoon-Cassini TA, Fitzgerald J, Krystal JH, Levy I, Olff M, Veltman DJ, Wang L, Neria Y, De Bellis MD, Jovanovic T, Daniels JK, Shenton ME, van de Wee NJA, Schmahl C, Kaufman ML, Rosso IM, Sponheim SR, Hofmann DB, Bryant RA, Fercho KA, Stein DJ, Mueller SC, Phan KL, McLaughlin KA, Davidson RJ, Larson C, May G, Nelson SM, Abdallah CG, Gomaa H, Etkin A, Seedat S, Harpaz-Rotem I, Liberzon I, Wang X, Thompson PM, Morey RA. Remodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results From the ENIGMA-PGC Posttraumatic Stress Disorder Consortium. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2022, 7: 935-948. PMID: 35307575, PMCID: PMC9835553, DOI: 10.1016/j.bpsc.2022.02.008.
- Bonomi R, Girgenti M, Krystal J, Cosgrove K. A Role for Histone Deacetylases in the Biology and Treatment of Post-Traumatic Stress Disorder: What Do We Know and Where Do We Go from Here? Complex Psychiatry 2022, 8: 13-27. PMID: 36545044, PMCID: PMC9669946, DOI: 10.1159/000524079.
- Pathak GA, Singh K, Wendt FR, Fleming TW, Overstreet C, Koller D, Tylee DS, De Angelis F, Cabrera Mendoza B, Levey DF, Koenen KC, Krystal JH, Pietrzak RH, O’ Donell C, Gaziano JM, Falcone G, Stein MB, Gelernter J, Pasaniuc B, Mancuso N, Davis LK, Polimanti R. Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits. Molecular Psychiatry 2022, 27: 1394-1404. PMID: 35241783, PMCID: PMC9210390, DOI: 10.1038/s41380-022-01488-9.
- Wisco BE, Nomamiukor FO, Marx BP, Krystal JH, Southwick SM, Pietrzak RH. Posttraumatic Stress Disorder in US Military Veterans: Results From the 2019-2020 National Health and Resilience in Veterans Study. The Journal Of Clinical Psychiatry 2022, 83 PMID: 35192748, DOI: 10.4088/jcp.20m14029.
- Wendt FR, Warrier V, Pathak GA, Koenen KC, Stein MB, Krystal JH, Pietrzak RH, Gelernter J, Goldfarb EV, Baron-Cohen S, Polimanti R. Polygenic scores for empathy associate with posttraumatic stress severity in response to certain traumatic events. Neurobiology Of Stress 2022, 17: 100439. PMID: 35242894, PMCID: PMC8881478, DOI: 10.1016/j.ynstr.2022.100439.
- Montalvo-Ortiz JL, Gelernter J, Cheng Z, Girgenti MJ, Xu K, Zhang X, Gopalan S, Zhou H, Duman RS, Southwick SM, Krystal JH, Pietrzak R. Epigenome-wide association study of posttraumatic stress disorder identifies novel loci in U.S. military veterans. Translational Psychiatry 2022, 12: 65. PMID: 35177594, PMCID: PMC8854688, DOI: 10.1038/s41398-022-01822-3.
- Holmes SE, Finnema SJ, Naganawa M, DellaGioia N, Holden D, Fowles K, Davis M, Ropchan J, Emory P, Ye Y, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Imaging the effect of ketamine on synaptic density (SV2A) in the living brain. Molecular Psychiatry 2022, 27: 2273-2281. PMID: 35165397, PMCID: PMC9133063, DOI: 10.1038/s41380-022-01465-2.
- Krystal J. Edward F. Domino, Ph.D. (1924–2021). Neuropsychopharmacology 2022, 47: 1138-1139. PMCID: PMC8938419, DOI: 10.1038/s41386-022-01280-x.
- Averill LA, Averill CL, Gueorguieva R, Fouda S, Sherif M, Ahn KH, Ranganathan M, D'Souza DC, Southwick SM, Sanacora G, Duman RS, Krystal JH, Abdallah CG. mTORC1 inhibitor effects on rapid ketamine-induced reductions in suicidal ideation in patients with treatment-resistant depression. Journal Of Affective Disorders 2022, 303: 91-97. PMID: 35101523, DOI: 10.1016/j.jad.2022.01.104.
- Abdallah CG, Roache JD, Gueorguieva R, Averill LA, Young-McCaughan S, Shiroma PR, Purohit P, Brundige A, Murff W, Ahn KH, Sherif MA, Baltutis EJ, Ranganathan M, D’Souza D, Martini B, Southwick SM, Petrakis IL, Burson RR, Guthmiller KB, López-Roca AL, Lautenschlager KA, McCallin JP, Hoch MB, Timchenko A, Souza SE, Bryant CE, Mintz J, Litz BT, Williamson DE, Keane TM, Peterson AL, Krystal JH. Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial. Neuropsychopharmacology 2022, 47: 1574-1581. PMID: 35046508, PMCID: PMC8767037, DOI: 10.1038/s41386-022-01266-9.
- Barron D, Heisig S, Agurto C, Norel R, Quagan B, Powers A, Birnbaum M, Constable T, Cecchi G, Krystal J. Feasibility Analysis of Phenotype Quantification from Unstructured Clinical Interactions. Computational Psychiatry 2022, 6: 1. PMID: 38774775, PMCID: PMC11104416, DOI: 10.5334/cpsy.78.
- Averill LA, Jiang L, Purohit P, Coppoli A, Averill CL, Roscoe J, Kelmendi B, De Feyter HM, de Graaf RA, Gueorguieva R, Sanacora G, Krystal JH, Rothman DL, Mason GF, Abdallah CG. Prefrontal Glutamate Neurotransmission in PTSD: A Novel Approach to Estimate Synaptic Strength in Vivo in Humans. Chronic Stress 2022, 6: 24705470221092734. PMID: 35434443, PMCID: PMC9008809, DOI: 10.1177/24705470221092734.
- Wunderlich G, Blahova Z, Hake S, Ikezawa S, Marder S, Falkai P, Krystal J. Efficacy and safety of BI 425809 in patients with schizophrenia: CONNEX, a Phase III randomised controlled trial programme. Neuroscience Applied 2022, 1: 100342. DOI: 10.1016/j.nsa.2022.100342.
- Clausen AN, Fercho KA, Monsour M, Disner S, Salminen L, Haswell CC, Rubright EC, Watts AA, Buckley MN, Maron-Katz A, Sierk A, Manthey A, Suarez-Jimenez B, Olatunji BO, Averill CL, Hofmann D, Veltman DJ, Olson EA, Li G, Forster GL, Walter H, Fitzgerald J, Théberge J, Simons JS, Bomyea JA, Frijling JL, Krystal JH, Baker JT, Phan KL, Ressler K, Han LKM, Nawijn L, Lebois LAM, Schmaal L, Densmore M, Shenton ME, van Zuiden M, Stein M, Fani N, Simons RM, Neufeld RWJ, Lanius R, van Rooij S, Koch SBJ, Bonomo S, Jovanovic T, deRoon-Cassini T, Ely TD, Magnotta VA, He X, Abdallah CG, Etkin A, Schmahl C, Larson C, Rosso IM, Blackford JU, Stevens JS, Daniels JK, Herzog J, Kaufman ML, Olff M, Davidson RJ, Sponheim SR, Mueller SC, Straube T, Zhu X, Neria Y, Baugh LA, Cole JH, Thompson PM, Morey RA. Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups. Brain And Behavior 2021, 12: e2413. PMID: 34907666, PMCID: PMC8785613, DOI: 10.1002/brb3.2413.
- Lam NH, Borduqui T, Hallak J, Roque A, Anticevic A, Krystal JH, Wang XJ, Murray JD. Effects of Altered Excitation-Inhibition Balance on Decision Making in a Cortical Circuit Model. Journal Of Neuroscience 2021, 42: 1035-1053. PMID: 34887320, PMCID: PMC8824494, DOI: 10.1523/jneurosci.1371-20.2021.
- Hill KP, Gold MS, Nemeroff CB, McDonald W, Grzenda A, Widge AS, Rodriguez C, Kraguljac NV, Krystal JH, Carpenter LL. Risks and Benefits of Cannabis and Cannabinoids in Psychiatry. American Journal Of Psychiatry 2021, 179: 98-109. PMID: 34875873, DOI: 10.1176/appi.ajp.2021.21030320.
- Nichter B, Stein MB, Monteith LL, Herzog S, Holliday R, Hill ML, Norman SB, Krystal JH, Pietrzak RH. Risk factors for suicide attempts among U.S. military veterans: A 7‐year population‐based, longitudinal cohort study. Suicide And Life-Threatening Behavior 2021, 52: 303-316. PMID: 34873738, DOI: 10.1111/sltb.12822.
- DeMartini KS, Gueorguieva R, Taylor JR, Krishnan-Sarin S, Pearlson G, Krystal JH, O'Malley SS. Dynamic structural equation modeling of the relationship between alcohol habit and drinking variability. Drug And Alcohol Dependence 2021, 233: 109202. PMID: 35151022, PMCID: PMC10046111, DOI: 10.1016/j.drugalcdep.2021.109202.
- Kachadourian L, Tsai J, Na PJ, Krystal JH, Southwick SM, Pietrzak RH. Resilience in the Face of the COVID-19 Pandemic: A National Study of US Military Veterans. The Primary Care Companion For CNS Disorders 2021, 23 PMID: 34763375, DOI: 10.4088/pcc.21br03075.
- Na PJ, De Angelis F, Nichter B, Wendt FR, Krystal JH, Southwick SM, Levey DF, Gelernter J, Polimanti R, Pietrzak RH. Psychosocial moderators of polygenic risk for suicidal ideation: Results from a 7-year population-based, prospective cohort study of U.S. veterans. Molecular Psychiatry 2021, 27: 1068-1074. PMID: 34725455, DOI: 10.1038/s41380-021-01352-2.
- Nichter B, Hill ML, Na PJ, Kline AC, Norman SB, Krystal JH, Southwick SM, Pietrzak RH. Prevalence and Trends in Suicidal Behavior Among US Military Veterans During the COVID-19 Pandemic. JAMA Psychiatry 2021, 78: 1218-1227. PMID: 34431973, PMCID: PMC8387942, DOI: 10.1001/jamapsychiatry.2021.2332.
- Krystal J. Potential Schizophrenia Medications Point to New Disease Model. Psychiatric News 2021, 56 DOI: 10.1176/appi.pn.2021.11.37.
- Bhatt S, Hillmer AT, Rusowicz A, Nabulsi N, Matuskey D, Angarita GA, Najafzadeh S, Kapinos M, Southwick SM, Krystal JH, Carson RE, Huang Y, Cosgrove KP. Imaging brain cortisol regulation in PTSD with a target for 11β-hydroxysteroid dehydrogenase type 1. Journal Of Clinical Investigation 2021, 131: e150452. PMID: 34651587, PMCID: PMC8516462, DOI: 10.1172/jci150452.
- Tamman AJF, Wendt FR, Pathak GA, Krystal JH, Southwick SM, Sippel LM, Gelernter J, Polimanti R, Pietrzak RH. Attachment Style Moderates Polygenic Risk for Incident Posttraumatic Stress in U.S. Military Veterans: A 7-Year, Nationally Representative, Prospective Cohort Study. Biological Psychiatry 2021, 91: 637-646. PMID: 34955171, DOI: 10.1016/j.biopsych.2021.09.025.
- Peterson AL, Young-McCaughan S, Roache JD, Mintz J, Litz BT, Williamson DE, Resick PA, Foa EB, McGeary DD, Dondanville KA, Taylor DJ, Wachen JS, Fox PT, Bryan CJ, McLean CP, Pruiksma KE, Yarvis JS, Niles BL, Abdallah CG, Averill LA, Back SE, Baker MT, Blount TH, Borah AM, Borah EV, Brock MS, Brown LA, Burg MM, Cigrang JA, DeBeer BB, DeVoe ER, Fina BA, Flanagan JC, Fredman SJ, Gardner CL, Gatchel RR, Goodie JL, Gueorguieva R, Higgs JB, Jacoby VM, Kelly KM, Krystal JH, Lapiz-Bluhm MD, López-Roca AL, Marx BP, Maurer DM, McDevitt-Murphy ME, McGeary CA, Meyer EC, Miles SR, Monson CM, Morilak DA, Moring JC, Mysliwiec V, Nicholson KL, Rauch SAM, Riggs DS, Rosen CS, Rudd MD, Schobitz RP, Schrader CC, Shinn AM, Shiroma PR, Sloan DM, Stern SL, Strong R, Vannoy SD, Young KA, Keane TM. STRONG STAR and the Consortium to Alleviate PTSD: Shaping the future of combat PTSD and related conditions in military and veteran populations. Contemporary Clinical Trials 2021, 110: 106583. PMID: 34600107, PMCID: PMC11392039, DOI: 10.1016/j.cct.2021.106583.
- Barron DS, Baker JT, Budde KS, Bzdok D, Eickhoff SB, Friston KJ, Fox PT, Geha P, Heisig S, Holmes A, Onnela JP, Powers A, Silbersweig D, Krystal JH. Decision Models and Technology Can Help Psychiatry Develop Biomarkers. Frontiers In Psychiatry 2021, 12: 706655. PMID: 34566711, PMCID: PMC8458705, DOI: 10.3389/fpsyt.2021.706655.
- Patel KT, Stevens MC, Dunlap A, Gallagher A, O’Malley S, DeMartini K, Potenza MN, Krystal JH, Pearlson GD. Effects of the Fyn kinase inhibitor saracatinib on ventral striatal activity during performance of an fMRI monetary incentive delay task in individuals family history positive or negative for alcohol use disorder. A pilot randomised trial. Neuropsychopharmacology 2021, 47: 840-846. PMID: 34475522, PMCID: PMC8882177, DOI: 10.1038/s41386-021-01157-5.
- Thompson SL, Gianessi CA, O'Malley SS, Cavallo DA, Shi JM, Tetrault JM, DeMartini KS, Gueorguieva R, Pittman B, Krystal JH, Taylor JR, Krishnan-Sarin S. Saracatinib Fails to Reduce Alcohol-Seeking and Consumption in Mice and Human Participants. Frontiers In Psychiatry 2021, 12: 709559. PMID: 34531767, PMCID: PMC8438169, DOI: 10.3389/fpsyt.2021.709559.
- Abi-Dargham A, Javitch JA, Slifstein M, Anticevic A, Calkins ME, Cho YT, Fonteneau C, Gil R, Girgis R, Gur RE, Gur RC, Grinband J, Kantrowitz J, Kohler C, Krystal J, Murray J, Ranganathan M, Santamauro N, Van Snellenberg J, Tamayo Z, Wolf D, D’Souza D, Srihari V, Gueorguieva R, Patel P, Forselius-Bielen K, Lu J, Butler A, Fram G, Afriyie-Agyemang Y, Selloni A, Cadavid L, Gomez-Luna S, Gupta A, Radhakrishnan R, Rashid A, Aker R, Abrahim P, Nia A, Surti T, Kegeles L, Carlson M, Goldberg T, Gangwisch J, Benedict E, Govil P, Brazis S, Mayer M, de la Garrigue N, Fallon N, Baumvoll T, Abeykoon S, Perlman G, Bobchin K, Elliott M, Schmidt L, Rush S, Port A, Heffernan Z, Laney N, Kantor J, Hohing T, Gray D, Lieberman J. Dopamine D1R Receptor Stimulation as a Mechanistic Pro-cognitive Target for Schizophrenia. Schizophrenia Bulletin 2021, 48: 199-210. PMID: 34423843, PMCID: PMC8781338, DOI: 10.1093/schbul/sbab095.
- Krystal JH, Chow B, Vessicchio J, Henrie AM, Neylan TC, Krystal AD, Marx BP, Xu K, Jindal RD, Davis LL, Schnurr PP, Stein MB, Thase ME, Ventura B, Huang GD, Shih MC, Team T. Design of the national adaptive trial for PTSD-related insomnia (NAP study), VA cooperative study program (CSP) #2016. Contemporary Clinical Trials 2021, 109: 106540. PMID: 34416369, DOI: 10.1016/j.cct.2021.106540.
- Krystal JH, Kelmendi B, Petrakis IL. Psychotherapy-supported MDMA treatment for PTSD. Cell Reports Medicine 2021, 2: 100378. PMID: 34467253, PMCID: PMC8385322, DOI: 10.1016/j.xcrm.2021.100378.
- Haeny AM, Gueorguieva R, Jackson A, Morean ME, Krishnan-Sarin S, DeMartini KS, Pearlson GD, Anticevic A, Krystal JH, O’Malley S. Individual Differences in the Associations Between Risk Factors for Alcohol Use Disorder and Alcohol Use-Related Outcomes. Psychology Of Addictive Behaviors 2021, 35: 501-513. PMID: 34110841, PMCID: PMC9211405, DOI: 10.1037/adb0000733.
- Burt JB, Preller KH, Demirtas M, Ji JL, Krystal JH, Vollenweider FX, Anticevic A, Murray JD. Transcriptomics-informed large-scale cortical model captures topography of pharmacological neuroimaging effects of LSD. ELife 2021, 10: e69320. PMID: 34313217, PMCID: PMC8315798, DOI: 10.7554/elife.69320.
- Nestler EJ, Krystal JH. Ronald S. Duman (1954–2020): In Memoriam. Biological Psychiatry 2021, 90: 72-73. DOI: 10.1016/j.biopsych.2021.05.010.
- Beck K, Hindley G, Borgan F, Ginestet C, McCutcheon R, Brugger S, Driesen N, Ranganathan M, D'Souza D, Taylor M, Krystal J, Howes O. The effect of ketamine on psychopathology and implications for understanding schizophrenia and its therapeutic use: a meta-analysis. BJPsych Open 2021, 7: s237-s237. PMCID: PMC8771247, DOI: 10.1192/bjo.2021.634.
- Hill ML, Nichter B, Na PJ, Norman SB, Morland LA, Krystal JH, Pietrzak RH. Mental health impact of the COVID-19 pandemic in U.S. military veterans: a population-based, prospective cohort study. Psychological Medicine 2021, 53: 945-956. PMID: 34120667, PMCID: PMC8245339, DOI: 10.1017/s0033291721002361.
- Barron D, Heisig S, Agurto C, Norel R, Quagan B, Powers A, Baker J, Constable T, Cecchi G, Krystal J. Preliminary Evaluation of Phenotypic Features from Clinical Interactions. Journal Of Pain 2021, 22: 594. DOI: 10.1016/j.jpain.2021.03.068.
- McClurkin M, Krystal J, Kaye A, Damisah E. Human iEEG Characterization of Threat and Anxiety Oscillations Across Amygdala, Hippocampus, and Frontal Cortex. Biological Psychiatry 2021, 89: s255. DOI: 10.1016/j.biopsych.2021.02.638.
- Girgenti M, Skarica M, Zhang J, Wang J, Friedman M, Zhao H, Krystal J. Integrative Functional Genomic Analysis of Human PTSD Molecular Pathology and Risk. Biological Psychiatry 2021, 89: s12. DOI: 10.1016/j.biopsych.2021.02.050.
- DeMartini KS, Gueorguieva R, Pearlson G, Krishnan‐Sarin S, Anticevic A, Ji LJ, Krystal JH, O’Malley S. Mapping data‐driven individualized neurobehavioral phenotypes in heavy alcohol drinkers. Alcohol Clinical And Experimental Research 2021, 45: 841-853. PMID: 33605439, DOI: 10.1111/acer.14580.
- Pietrzak RH, Javier FG, Krystal JH, Southwick SM. Subthreshold post-traumatic stress disorder as a risk factor for post-traumatic stress disorder: results from a sample of USA veterans. The British Journal Of Psychiatry 2021, 219: 456-459. PMID: 35048836, DOI: 10.1192/bjp.2021.17.
- Wendt FR, Pathak GA, Levey DF, Nuñez YZ, Overstreet C, Tyrrell C, Adhikari K, De Angelis F, Tylee DS, Goswami A, Krystal JH, Abdallah CG, Stein MB, Kranzler HR, Gelernter J, Polimanti R. Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality. Neurobiology Of Stress 2021, 14: 100309. PMID: 33665242, PMCID: PMC7905234, DOI: 10.1016/j.ynstr.2021.100309.
- Lee EE, Torous J, De Choudhury M, Depp CA, Graham SA, Kim HC, Paulus MP, Krystal JH, Jeste DV. Artificial Intelligence for Mental Health Care: Clinical Applications, Barriers, Facilitators, and Artificial Wisdom. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2021, 6: 856-864. PMID: 33571718, PMCID: PMC8349367, DOI: 10.1016/j.bpsc.2021.02.001.
- Barron DS, Gao S, Dadashkarimi J, Greene AS, Spann MN, Noble S, Lake EMR, Krystal JH, Constable RT, Scheinost D. Transdiagnostic, Connectome-Based Prediction of Memory Constructs Across Psychiatric Disorders. Cerebral Cortex 2020, 31: 2523-2533. PMID: 33345271, PMCID: PMC8023861, DOI: 10.1093/cercor/bhaa371.
- Wendt FR, Pathak GA, Lencz T, Krystal JH, Gelernter J, Polimanti R. Multivariate genome-wide analysis of education, socioeconomic status and brain phenome. Nature Human Behaviour 2020, 5: 482-496. PMID: 33349686, PMCID: PMC8068566, DOI: 10.1038/s41562-020-00980-y.
- Girgenti MJ, Wang J, Ji D, Cruz DA, Stein M, Gelernter J, Young K, Huber B, Williamson D, Friedman M, Krystal J, Zhao H, Duman R. Transcriptomic organization of the human brain in post-traumatic stress disorder. Nature Neuroscience 2020, 24: 24-33. PMID: 33349712, DOI: 10.1038/s41593-020-00748-7.
- Hamilton HK, Roach BJ, Cavus I, Teyler TJ, Clapp WC, Ford JM, Tarakci E, Krystal JH, Mathalon DH. Impaired Potentiation of Theta Oscillations During a Visual Cortical Plasticity Paradigm in Individuals With Schizophrenia. Frontiers In Psychiatry 2020, 11: 590567. PMID: 33391054, PMCID: PMC7772351, DOI: 10.3389/fpsyt.2020.590567.
- Fogle BM, Tsai J, Mota N, Harpaz-Rotem I, Krystal JH, Southwick SM, Pietrzak RH. The National Health and Resilience in Veterans Study: A Narrative Review and Future Directions. Frontiers In Psychiatry 2020, 11: 538218. PMID: 33362593, PMCID: PMC7755975, DOI: 10.3389/fpsyt.2020.538218.
- Wang X, Xie H, Chen T, Cotton AS, Salminen LE, Logue MW, Clarke-Rubright EK, Wall J, Dennis EL, O’Leary B, Abdallah CG, Andrew E, Baugh LA, Bomyea J, Bruce SE, Bryant R, Choi K, Daniels JK, Davenport ND, Davidson RJ, DeBellis M, deRoon-Cassini T, Disner SG, Fani N, Fercho KA, Fitzgerald J, Forster GL, Frijling JL, Geuze E, Gomaa H, Gordon EM, Grupe D, Harpaz-Rotem I, Haswell CC, Herzog JI, Hofmann D, Hollifield M, Hosseini B, Hudson AR, Ipser J, Jahanshad N, Jovanovic T, Kaufman ML, King AP, Koch SBJ, Koerte IK, Korgaonkar MS, Krystal JH, Larson C, Lebois LAM, Levy I, Li G, Magnotta VA, Manthey A, May G, McLaughlin KA, Mueller SC, Nawijn L, Nelson SM, Neria Y, Nitschke JB, Olff M, Olson EA, Peverill M, Phan K, Rashid FM, Ressler K, Rosso IM, Sambrook K, Schmahl C, Shenton ME, Sierk A, Simons JS, Simons RM, Sponheim SR, Stein MB, Stein DJ, Stevens JS, Straube T, Suarez-Jimenez B, Tamburrino M, Thomopoulos SI, van der Wee NJA, van der Werff SJA, van Erp TGM, van Rooij SJH, van Zuiden M, Varkevisser T, Veltman DJ, Vermeiren RRJM, Walter H, Wang L, Zhu Y, Zhu X, Thompson PM, Morey RA, Liberzon I. Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis. Molecular Psychiatry 2020, 26: 4331-4343. PMID: 33288872, PMCID: PMC8180531, DOI: 10.1038/s41380-020-00967-1.
- Spiegelman D, Lovato LC, Khudyakov P, Wilkens TL, Adebamowo CA, Adebamowo SN, Appel LJ, Beulens JW, Coughlin JW, Dragsted LO, Edenberg HJ, Eriksen JN, Estruch R, Grobbee DE, Gulayin PE, Irazola V, Krystal JH, Lazo M, Murray MM, Rimm EB, Schrieks IC, Williamson JD, Mukamal KJ. The Moderate Alcohol and Cardiovascular Health Trial (MACH15): Design and methods for a randomized trial of moderate alcohol consumption and cardiometabolic risk. European Journal Of Preventive Cardiology 2020, 27: 1967-1982. PMID: 32250171, PMCID: PMC7541556, DOI: 10.1177/2047487320912376.
- Steine IM, Nielsen B, Porter PA, Krystal JH, Winje D, Grønli J, Milde AM, Bjorvatn B, Nordhus IH, Pallesen S. Predictors and correlates of lifetime and persistent non-suicidal self-injury and suicide attempts among adult survivors of childhood sexual abuse. European Journal Of Psychotraumatology 2020, 11: 1815282. PMID: 33312451, PMCID: PMC7717684, DOI: 10.1080/20008198.2020.1815282.
- Krystal JH. Publisher Correction: Responding to the hidden pandemic for healthcare workers: stress. Nature Medicine 2020, 26: 1951-1951. PMID: 33247290, DOI: 10.1038/s41591-020-01176-7.
- Krystal JH, Alvarado J, Ball SA, Fortunati FG, Hu M, Ivy ME, Kapo J, Olson KD, Rohrbaugh RM, Sinha R, Tebes JK, Vender RJ, Yonkers KA, Mayes LC. Mobilizing an institutional supportive response for healthcare workers and other staff in the context of COVID-19: The Yale experience. General Hospital Psychiatry 2020, 68: 12-18. PMID: 33254081, PMCID: PMC7680059, DOI: 10.1016/j.genhosppsych.2020.11.005.
- Moujaes F, Preller K, Vollenweider F, Schleifer C, Adkinson B, Kolobaric A, Fineberg S, Krystal J, Repovs G, Santamauro N, Morgan P, Savic A, Cho Y, D. M, Anticevic A. P.499 Ketamine's influence on global resting-state functional connectivity and individual variation in neuro-behavioural relationships. European Neuropsychopharmacology 2020, 40: s278-s279. DOI: 10.1016/j.euroneuro.2020.09.363.
- Krystal JH, Barch DM, Carter CS. Introducing a New Journal, Biological Psychiatry: Global Open Science. Biological Psychiatry 2020, 88: 890. PMID: 33213699, DOI: 10.1016/j.biopsych.2020.10.005.
- Characteristics of Ongoing Clinical Trials for Alcohol Use Disorder Registered on ClinicalTrials.govWallach JD, Krystal JH, Ross JS, O’Malley S. Characteristics of Ongoing Clinical Trials for Alcohol Use Disorder Registered on ClinicalTrials.gov. JAMA Psychiatry 2020, 77: 1081-1084. PMID: 32459295, PMCID: PMC7254444, DOI: 10.1001/jamapsychiatry.2020.1167.
- Tamman AJF, Wendt FR, Pathak GA, Krystal JH, Montalvo-Ortiz JL, Southwick SM, Sippel LM, Gelernter J, Polimanti R, Pietrzak RH. Attachment Style Moderates Polygenic Risk for Posttraumatic Stress in United States Military Veterans: Results From the National Health and Resilience in Veterans Study. Biological Psychiatry 2020, 89: 878-887. PMID: 33276944, DOI: 10.1016/j.biopsych.2020.09.018.
- Abdallah CG, Ahn KH, Averill LA, Nemati S, Averill CL, Fouda S, Ranganathan M, Morgan PT, D’Souza D, Mathalon DH, Krystal JH, Driesen NR. A robust and reproducible connectome fingerprint of ketamine is highly associated with the connectomic signature of antidepressants. Neuropsychopharmacology 2020, 46: 478-485. PMID: 32967000, PMCID: PMC7852889, DOI: 10.1038/s41386-020-00864-9.
- Stone LA, Girgenti MJ, Wang J, Ji D, Zhao H, Krystal JH, Duman R. Cortical Transcriptomic Alterations in Association With Appetitive Neuropeptides and Body Mass Index in Posttraumatic Stress Disorder. The International Journal Of Neuropsychopharmacology 2020, 24: 118-129. PMID: 32951025, PMCID: PMC8611677, DOI: 10.1093/ijnp/pyaa072.
- Hillmer AT, Angarita GA, Esterlis I, Anderson JM, Nabulsi N, Lim K, Ropchan J, Carson RE, Krystal JH, Malley S, Cosgrove KP. Longitudinal imaging of metabotropic glutamate 5 receptors during early and extended alcohol abstinence. Neuropsychopharmacology 2020, 46: 380-385. PMID: 32919411, PMCID: PMC7852514, DOI: 10.1038/s41386-020-00856-9.
- Li L, Li F, Fortunati F, Krystal JH. Association of a Prior Psychiatric Diagnosis With Mortality Among Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) Infection. JAMA Network Open 2020, 3: e2023282. PMID: 32997123, PMCID: PMC7527869, DOI: 10.1001/jamanetworkopen.2020.23282.
- Mason GF, Krystal JH. Mapping Lithium in the Brain: New 3-Dimensional Methodology Reveals Regional Distribution in Euthymic Patients With Bipolar Disorder. Biological Psychiatry 2020, 88: 367-368. PMID: 32792052, DOI: 10.1016/j.biopsych.2020.05.023.
- Krystal J. Robert T. Malison, M.D. (1959–2020). Neuropsychopharmacology 2020, 45: 2133-2134. PMCID: PMC7547671, DOI: 10.1038/s41386-020-00817-2.
- Kaye AP, Krystal JH. Predictive Processing in Mental Illness: Hierarchical Circuitry for Perception and Trauma. Journal Of Psychopathology And Clinical Science 2020, 129: 629-632. PMID: 32757606, DOI: 10.1037/abn0000628.
- Aghajanian GK, Mathé AA, Eriksson E, Krystal JH. Torgny Svensson, M.D., Ph.D. (1945–2020). Neuropsychopharmacology 2020, 45: 1960-1960. PMID: 32699343, PMCID: PMC7374074, DOI: 10.1038/s41386-020-0770-4.
- Moreno C, Wykes T, Galderisi S, Nordentoft M, Crossley N, Jones N, Cannon M, Correll CU, Byrne L, Carr S, Chen EYH, Gorwood P, Johnson S, Kärkkäinen H, Krystal JH, Lee J, Lieberman J, López-Jaramillo C, Männikkö M, Phillips MR, Uchida H, Vieta E, Vita A, Arango C. How mental health care should change as a consequence of the COVID-19 pandemic. The Lancet Psychiatry 2020, 7: 813-824. PMID: 32682460, PMCID: PMC7365642, DOI: 10.1016/s2215-0366(20)30307-2.
- Steine IM, Winje D, Krystal JH, Milde AM, Bjorvatn B, Nordhus IH, Grønli J, Pallesen S. Longitudinal Relationships between Perceived Social Support and Symptom Outcomes: Findings from a sample of Adult Survivors of Childhood Sexual Abuse. Child Abuse & Neglect 2020, 107: 104566. PMID: 32526550, DOI: 10.1016/j.chiabu.2020.104566.
- Kantrowitz JT, Grinband J, Goff DC, Lahti AC, Marder SR, Kegeles LS, Girgis RR, Sobeih T, Wall MM, Choo TH, Green MF, Yang YS, Lee J, Horga G, Krystal JH, Potter WZ, Javitt DC, Lieberman JA. Proof of mechanism and target engagement of glutamatergic drugs for the treatment of schizophrenia: RCTs of pomaglumetad and TS-134 on ketamine-induced psychotic symptoms and pharmacoBOLD in healthy volunteers. Neuropsychopharmacology 2020, 45: 1842-1850. PMID: 32403118, PMCID: PMC7608251, DOI: 10.1038/s41386-020-0706-z.
- Gur TL, Krystal JH. Biological Psychiatry Podcast Series: Support Resources for the COVID-19 Pandemic. Biological Psychiatry 2020, 88: 3. PMID: 32405077, PMCID: PMC7217797, DOI: 10.1016/j.biopsych.2020.05.008.
- Bhatt S, Hillmer AT, Girgenti MJ, Rusowicz A, Kapinos M, Nabulsi N, Huang Y, Matuskey D, Angarita GA, Esterlis I, Davis MT, Southwick SM, Friedman MJ, Duman R, Carson R, Krystal J, Pietrzak R, Cosgrove K. PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies. Nature Communications 2020, 11: 2360. PMID: 32398677, PMCID: PMC7217830, DOI: 10.1038/s41467-020-15930-5.
- Abdallah CG, Krystal JH. Ketamine and rapid acting antidepressants: Are we ready to cure, rather than treat depression? Behavioural Brain Research 2020, 390: 112628. PMID: 32407817, PMCID: PMC7316409, DOI: 10.1016/j.bbr.2020.112628.
- Barron D, Bzdok D, Krystal J, Constable R. What Can Machine Learning Do for Psychiatry? Biological Psychiatry 2020, 87: s462. DOI: 10.1016/j.biopsych.2020.02.1176.
- Barron D, Heisig S, Norel R, Agurto C, Quagan B, Powers A, Baker J, Constable R, Cecchi G, Krystal J. Preliminary Phenotypic Feature Capture During Clinical Interaction. Biological Psychiatry 2020, 87: s212-s213. DOI: 10.1016/j.biopsych.2020.02.552.
- Nemati S, Akiki T, Ju Y, Averill C, Fouda S, Dutta A, Mckie S, Krystal J, Deakin B, Averill L, Abdallah C. A Shift in Executive Connectivity Predates and Predicts Response to Treatment in Major Depressive Disorder. Biological Psychiatry 2020, 87: s107. DOI: 10.1016/j.biopsych.2020.02.294.
- Wendt F, Pathak G, Lencz T, Krystal J, Gelernter J, Polimanti R. Education and Socioeconomic Status Mask the Identification of Brain Cell Types in GWAS of Mental Health and Disease. Biological Psychiatry 2020, 87: s110. DOI: 10.1016/j.biopsych.2020.02.302.
- Beck K, Hindley G, Borgan F, Ginestet C, McCutcheon R, Brugger S, Driesen N, Ranganathan M, D’Souza D, Taylor M, Krystal JH, Howes OD. Association of Ketamine With Psychiatric Symptoms and Implications for Its Therapeutic Use and for Understanding Schizophrenia. JAMA Network Open 2020, 3: e204693. PMID: 32437573, PMCID: PMC7243091, DOI: 10.1001/jamanetworkopen.2020.4693.
- Stone L, Girgenti M, Krystal J, Duman R, Group T. Neural Transcriptomic Alterations Associated With Neuropeptide Y and Ghrelin in Posttraumatic Stress Disorder. Biological Psychiatry 2020, 87: s421-s422. DOI: 10.1016/j.biopsych.2020.02.1075.
- Girgenti M, Wang J, Ji D, Cruz D, Group T, Program M, Stein M, Gelernter J, Young K, Huber B, Williamson D, Friedman M, Krystal J, Zhao H, Duman R. Transcriptomic Organization of Human Posttraumatic Stress Disorder. Biological Psychiatry 2020, 87: s122. DOI: 10.1016/j.biopsych.2020.02.330.
- DeMartini KS, Pittman B, Krystal JH, O’Malley S, Krishnan‐Sarin S. Examining the Relationship Between Self‐Reported Drinking and In‐Laboratory Drinking and Craving: Is There Concordance? Alcohol Clinical And Experimental Research 2020, 44: 1151-1157. PMID: 32352581, PMCID: PMC10158572, DOI: 10.1111/acer.14329.
- Krystal JH. Responding to the hidden pandemic for healthcare workers: stress. Nature Medicine 2020, 26: 639-639. PMID: 32350461, DOI: 10.1038/s41591-020-0878-4.
- Koblan KS, Kent J, Hopkins SC, Krystal JH, Cheng H, Goldman R, Loebel A. A Non–D2-Receptor-Binding Drug for the Treatment of Schizophrenia. New England Journal Of Medicine 2020, 382: 1497-1506. PMID: 32294346, DOI: 10.1056/nejmoa1911772.
- Keizer BM, Roache JD, Jones JR, Kalpinski RJ, Porcerelli JH, Krystal JH. Continuous Ketamine Infusion for Pain as an Opportunity for Psychotherapy for PTSD: A Case Series of Ketamine-Enhanced Psychotherapy for PTSD and Pain (KEP-P2). Psychotherapy And Psychosomatics 2020, 89: 326-329. PMID: 32248200, DOI: 10.1159/000507095.
- Krystal JH, Charney DS, Duman RS. A New Rapid-Acting Antidepressant. Cell 2020, 181: 7. PMID: 32243798, DOI: 10.1016/j.cell.2020.02.033.
- Nestler E, Krystal J. Ronald S. Duman (1954–2020). Neuron 2020, 105: 769-770. DOI: 10.1016/j.neuron.2020.02.018.
- Hu Y, Ranganathan M, Shu C, Liang X, Ganesh S, Osafo-Addo A, Yan C, Zhang X, Aouizerat BE, Krystal JH, D’Souza D, Xu K. Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Scientific Reports 2020, 10: 3450. PMID: 32103029, PMCID: PMC7044203, DOI: 10.1038/s41598-020-59827-1.
- Abdallah CG, Averill LA, Gueorguieva R, Goktas S, Purohit P, Ranganathan M, Sherif M, Ahn KH, D’Souza D, Formica R, Southwick SM, Duman RS, Sanacora G, Krystal JH. Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin. Neuropsychopharmacology 2020, 45: 990-997. PMID: 32092760, PMCID: PMC7162891, DOI: 10.1038/s41386-020-0644-9.
- Krystal J, Nestler E, Picciotto M. Ronald S. Duman, Ph.D. (1954–2020). Neuropsychopharmacology 2020, 45: 1078-1078. PMCID: PMC7162938, DOI: 10.1038/s41386-020-0642-y.
- Garrison KA, DeMartini KS, Corlett PR, Worhunsky PD, Krystal JH, O'Malley SS. Drinking and responses to antidrinking messages among young adults: An fMRI study. Addiction Biology 2020, 26: e12882. PMID: 32068323, PMCID: PMC7431375, DOI: 10.1111/adb.12882.
- Hartwell EE, Feinn R, Morris PE, Gelernter J, Krystal J, Arias AJ, Hoffman M, Petrakis I, Gueorguieva R, Schacht JP, Oslin D, Anton RF, Kranzler HR. Systematic review and meta‐analysis of the moderating effect of rs1799971 in OPRM1, the mu‐opioid receptor gene, on response to naltrexone treatment of alcohol use disorder. Addiction 2020, 115: 1426-1437. PMID: 31961981, PMCID: PMC7340566, DOI: 10.1111/add.14975.
- Liang X, Justice AC, So-Armah K, Krystal JH, Sinha R, Xu K. DNA methylation signature on phosphatidylethanol, not on self-reported alcohol consumption, predicts hazardous alcohol consumption in two distinct populations. Molecular Psychiatry 2020, 26: 2238-2253. PMID: 32034291, PMCID: PMC8440221, DOI: 10.1038/s41380-020-0668-x.
- Krystal JH. Imaging the glutamate synapse. Nature Medicine 2020, 26: 165-167. PMID: 32015559, DOI: 10.1038/s41591-020-0760-4.
- Preller KH, Duerler P, Burt JB, Ji JL, Adkinson B, Stämpfli P, Seifritz E, Repovš G, Krystal JH, Murray JD, Anticevic A, Vollenweider FX. Psilocybin Induces Time-Dependent Changes in Global Functional Connectivity. Biological Psychiatry 2020, 88: 197-207. PMID: 32111343, DOI: 10.1016/j.biopsych.2019.12.027.
- McCutcheon RA, Krystal JH, Howes OD. Dopamine and glutamate in schizophrenia: biology, symptoms and treatment. World Psychiatry 2020, 19: 15-33. PMID: 31922684, PMCID: PMC6953551, DOI: 10.1002/wps.20693.
- Krystal JH. Preface: Remembering Ronald Stanton Duman, Ph.D. Advances In Pharmacology 2020, 89: xv-xvi. PMID: 32616216, DOI: 10.1016/s1054-3589(20)30048-x.
- Suzuki S, Mell MM, O'Malley SS, Krystal JH, Anticevic A, Kober H. Regulation of Craving and Negative Emotion in Alcohol Use Disorder. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 5: 239-250. PMID: 31892465, PMCID: PMC7010564, DOI: 10.1016/j.bpsc.2019.10.005.
- Nemati S, Akiki TJ, Roscoe J, Ju Y, Averill CL, Fouda S, Dutta A, McKie S, Krystal JH, Deakin JFW, Averill LA, Abdallah CG. A Unique Brain Connectome Fingerprint Predates and Predicts Response to Antidepressants. IScience 2019, 23: 100800. PMID: 31918047, PMCID: PMC6992944, DOI: 10.1016/j.isci.2019.100800.
- Dennis EL, Disner SG, Fani N, Salminen LE, Logue M, Clarke EK, Haswell CC, Averill CL, Baugh LA, Bomyea J, Bruce SE, Cha J, Choi K, Davenport ND, Densmore M, du Plessis S, Forster GL, Frijling JL, Gonenc A, Gruber S, Grupe DW, Guenette JP, Hayes J, Hofmann D, Ipser J, Jovanovic T, Kelly S, Kennis M, Kinzel P, Koch SBJ, Koerte I, Koopowitz S, Korgaonkar M, Krystal J, Lebois LAM, Li G, Magnotta VA, Manthey A, May GJ, Menefee DS, Nawijn L, Nelson SM, Neufeld RWJ, Nitschke JB, O’Doherty D, Peverill M, Ressler KJ, Roos A, Sheridan MA, Sierk A, Simmons A, Simons RM, Simons JS, Stevens J, Suarez-Jimenez B, Sullivan DR, Théberge J, Tran JK, van den Heuvel L, van der Werff SJA, van Rooij SJH, van Zuiden M, Velez C, Verfaellie M, Vermeiren RRJM, Wade BSC, Wager T, Walter H, Winternitz S, Wolff J, York G, Zhu Y, Zhu X, Abdallah CG, Bryant R, Daniels JK, Davidson RJ, Fercho KA, Franz C, Geuze E, Gordon EM, Kaufman ML, Kremen WS, Lagopoulos J, Lanius RA, Lyons MJ, McCauley SR, McGlinchey R, McLaughlin KA, Milberg W, Neria Y, Olff M, Seedat S, Shenton M, Sponheim SR, Stein DJ, Stein MB, Straube T, Tate DF, van der Wee NJA, Veltman DJ, Wang L, Wilde EA, Thompson PM, Kochunov P, Jahanshad N, Morey RA. Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium. Molecular Psychiatry 2019, 26: 4315-4330. PMID: 31857689, PMCID: PMC7302988, DOI: 10.1038/s41380-019-0631-x.
- Haeny AM, Gueorguieva R, Morean ME, Krishnan‐Sarin S, DeMartini KS, Pearlson GD, Anticevic A, Krystal JH, O'Malley SS. The Association of Impulsivity and Family History of Alcohol Use Disorder on Alcohol Use and Consequences. Alcohol Clinical And Experimental Research 2019, 44: 159-167. PMID: 31693193, PMCID: PMC6981005, DOI: 10.1111/acer.14230.
- Holmes SE, Gallezot JD, Davis MT, DellaGioia N, Matuskey D, Nabulsi N, Krystal JH, Javitch JA, DeLorenzo C, Carson RE, Esterlis I. Measuring the effects of ketamine on mGluR5 using [18F]FPEB and PET. Cerebrovascular And Brain Metabolism Reviews 2019, 40: 2254-2264. PMID: 31744389, PMCID: PMC7585925, DOI: 10.1177/0271678x19886316.
- Krishnan-Sarin S, O’Malley S, Franco N, Cavallo DA, Tetrault JM, Shi J, Gueorguieva R, Pittman B, Krystal JH. Influence of combined treatment with naltrexone and memantine on alcohol drinking behaviors: a phase II randomized crossover trial. Neuropsychopharmacology 2019, 45: 319-326. PMID: 31590179, PMCID: PMC6901445, DOI: 10.1038/s41386-019-0536-z.
- Mota NP, Cook JM, Smith NB, Tsai J, Harpaz-Rotem I, Krystal JH, Southwick SM, Pietrzak RH. Posttraumatic stress symptom courses in U.S. military veterans: A seven-year, nationally representative, prospective cohort study. Journal Of Psychiatric Research 2019, 119: 23-31. PMID: 31546045, DOI: 10.1016/j.jpsychires.2019.09.005.
- Xu K, Montalvo‐Ortiz J, Zhang X, Southwick SM, Krystal JH, Pietrzak RH, Gelernter J. Epigenome‐Wide DNA Methylation Association Analysis Identified Novel Loci in Peripheral Cells for Alcohol Consumption Among European American Male Veterans. Alcohol Clinical And Experimental Research 2019, 43: 2111-2121. PMID: 31386212, PMCID: PMC9377208, DOI: 10.1111/acer.14168.
- Chen MH, Cheng CM, Gueorguieva R, Lin WC, Li CT, Hong CJ, Tu PC, Bai YM, Tsai SJ, Krystal JH, Su TP. Maintenance of antidepressant and antisuicidal effects by D-cycloserine among patients with treatment-resistant depression who responded to low-dose ketamine infusion: a double-blind randomized placebo–control study. Neuropsychopharmacology 2019, 44: 2112-2118. PMID: 31421635, PMCID: PMC6898334, DOI: 10.1038/s41386-019-0480-y.
- Averill LA, Abdallah CG, Levey DF, Han S, Harpaz‐Rotem I, Kranzler HR, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study. Depression And Anxiety 2019, 36: 834-845. PMID: 31385647, DOI: 10.1002/da.22912.
- Quagliato LA, Cosci F, Shader RI, Silberman EK, Starcevic V, Balon R, Dubovsky SL, Salzman C, Krystal JH, Weintraub SJ, Freire RC, Nardi AE, Benzodiazepines I. Selective serotonin reuptake inhibitors and benzodiazepines in panic disorder: A meta-analysis of common side effects in acute treatment. Journal Of Psychopharmacology 2019, 33: 1340-1351. PMID: 31304840, DOI: 10.1177/0269881119859372.
- Kaffman A, White JD, Wei L, Johnson FK, Krystal JH. Enhancing the Utility of Preclinical Research in Neuropsychiatry Drug Development. Methods In Molecular Biology 2019, 2011: 3-22. PMID: 31273690, PMCID: PMC6895673, DOI: 10.1007/978-1-4939-9554-7_1.
- Wang W, Zhornitsky S, Le TM, Dhingra I, Zhang S, Krystal JH, Li CR. Cue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers. Journal Of Psychiatric Research 2019, 116: 74-82. PMID: 31202048, PMCID: PMC6606341, DOI: 10.1016/j.jpsychires.2019.06.005.
- Ji JL, Diehl C, Schleifer C, Tamminga CA, Keshavan MS, Sweeney JA, Clementz BA, Hill SK, Pearlson G, Yang G, Creatura G, Krystal JH, Repovs G, Murray J, Winkler A, Anticevic A. Schizophrenia Exhibits Bi-directional Brain-Wide Alterations in Cortico-Striato-Cerebellar Circuits. Cerebral Cortex 2019, 29: 4463-4487. PMID: 31157363, PMCID: PMC6917525, DOI: 10.1093/cercor/bhy306.
- Krystal JH, Yoon G, Petrakis IL. Rigorous Trial Design Is Essential to Understand the Role of Opioid Receptors in Ketamine’s Antidepressant Effect—Reply. JAMA Psychiatry 2019, 76: 658-659. PMID: 31042270, DOI: 10.1001/jamapsychiatry.2019.0763.
- Steine IM, Skogen JC, Krystal JH, Winje D, Milde AM, Grønli J, Nordhus IH, Bjorvatn B, Pallesen S. Insomnia symptom trajectories among adult survivors of childhood sexual abuse: A longitudinal study. Child Abuse & Neglect 2019, 93: 263-276. PMID: 31129428, DOI: 10.1016/j.chiabu.2019.05.009.
- Davis MT, Hillmer A, Holmes SE, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Angarita G, Carson RE, Krystal JH, Esterlis I. In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 11490-11495. PMID: 31085640, PMCID: PMC6561298, DOI: 10.1073/pnas.1818871116.
- Barron D, Gao S, Greene A, Constable R, Krystal J, Scheinost D. S179. Transdiagnostic Prediction of Memory and Executive Function From Whole-Brain Functional Connectivity. Biological Psychiatry 2019, 85: s366-s367. DOI: 10.1016/j.biopsych.2019.03.930.
- Cho Y, Schleifer C, Moujaes F, Starc M, Ji J, Santamauro N, Adkinson B, Kolobaric A, Flynn M, Krystal J, Murray J, Repovs G, Anticevic A. T193. Monetary Incentives Shape Behavioral and Neural Precision of Spatial Working Memory. Biological Psychiatry 2019, 85: s204-s205. DOI: 10.1016/j.biopsych.2019.03.516.
- Kaye A, Ressler K, Krystal J. S16. PTSD as a Threat Mood: Insights From a Reinforcement Learning Model. Biological Psychiatry 2019, 85: s302. DOI: 10.1016/j.biopsych.2019.03.767.
- Kolobaric A, Anticevic A, Hu X, Xiao Y, Hu J, Li F, Bi F, Cole M, Savic A, Yang G, Repovs G, Murray J, Wang X, Huang X, Lui S, Krystal J, Gong Q. T174. Examining the Neurobiological Progression of Early Course Schizophrenia. Biological Psychiatry 2019, 85: s196-s197. DOI: 10.1016/j.biopsych.2019.03.497.
- Hamilton H, Ford J, Roach B, Gunduz-Bruce H, Krystal J, Jaeger J, Reinhart R, Mathalon D. T161. Effects of Ketamine Administration on the P300 Event-Related Potential: Implications for Schizophrenia. Biological Psychiatry 2019, 85: s191. DOI: 10.1016/j.biopsych.2019.03.484.
- Moujaes F, Schleifer C, Ji L, Adkinson B, Kolobaric A, Flynn M, Fineberg S, Krystal J, Repovs G, Cho Y, Santamauro N, Morgan P, Savic A, Murray J, Anticevic A. F195. NMDAR Antagonism via Ketamine Differentially Modulates Thalamic Versus Hippocampal Brain-Wide Functional Connectivity. Biological Psychiatry 2019, 85: s289. DOI: 10.1016/j.biopsych.2019.03.732.
- Burt J, Preller K, Demirtas M, Ji J, Krystal J, Vollenweider F, Anticevic A, Murray J. S175. Large-Scale Model of Human Cortex Captures LSD-Induced Functional Alterations via HTR2A-Mediated Neural Gain Modulation. Biological Psychiatry 2019, 85: s365. DOI: 10.1016/j.biopsych.2019.03.926.
- Moujaes F, Preller K, Vollenweider F, Schleifer C, Ji J, Adkinson B, Kolobaric A, Flynn M, Fineberg S, Krystal J, Repovs G, Santamauro N, Morgan P, Savic A, Cho Y, Murray J, Anticevic A. S159. NMDA Receptor Antagonism Effects on Delayed Spatial Working Memory and Distraction in Comparison With Schizophrenia. Biological Psychiatry 2019, 85: s358. DOI: 10.1016/j.biopsych.2019.03.910.
- Abdallah CG, Roache JD, Averill LA, Young-McCaughan S, Martini B, Gueorguieva R, Amoroso T, Southwick SM, Guthmiller K, López-Roca AL, Lautenschlager K, Mintz J, Litz BT, Williamson DE, Keane TM, Peterson AL, Krystal JH, PTSD F. Repeated ketamine infusions for antidepressant-resistant PTSD: Methods of a multicenter, randomized, placebo-controlled clinical trial. Contemporary Clinical Trials 2019, 81: 11-18. PMID: 30999057, DOI: 10.1016/j.cct.2019.04.009.
- Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Lower synaptic density is associated with depression severity and network alterations. Nature Communications 2019, 10: 1529. PMID: 30948709, PMCID: PMC6449365, DOI: 10.1038/s41467-019-09562-7.
- Duman RS, Sanacora G, Krystal JH. Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments. Neuron 2019, 102: 75-90. PMID: 30946828, PMCID: PMC6450409, DOI: 10.1016/j.neuron.2019.03.013.
- Krystal JH, Abdallah CG, Sanacora G, Charney DS, Duman RS. Ketamine: A Paradigm Shift for Depression Research and Treatment. Neuron 2019, 101: 774-778. PMID: 30844397, PMCID: PMC6560624, DOI: 10.1016/j.neuron.2019.02.005.
- Yoon G, Petrakis IL, Krystal JH. Association of Combined Naltrexone and Ketamine With Depressive Symptoms in a Case series of Patients With Depression and Alcohol Use Disorder. JAMA Psychiatry 2019, 76: 337-338. PMID: 30624551, PMCID: PMC6439824, DOI: 10.1001/jamapsychiatry.2018.3990.
- Fleming LM, Javitt DC, Carter CS, Kantrowitz JT, Girgis RR, Kegeles LS, Ragland JD, Maddock RJ, Lesh TA, Tanase C, Robinson J, Potter WZ, Carlson M, Wall MM, Choo TH, Grinband J, Lieberman J, Krystal JH, Corlett PR. A multicenter study of ketamine effects on functional connectivity: Large scale network relationships, hubs and symptom mechanisms. NeuroImage Clinical 2019, 22: 101739. PMID: 30852397, PMCID: PMC6411494, DOI: 10.1016/j.nicl.2019.101739.
- Homan P, Levy I, Feltham E, Gordon C, Hu J, Li J, Pietrzak RH, Southwick S, Krystal JH, Harpaz-Rotem I, Schiller D. Author Correction: Neural computations of threat in the aftermath of combat trauma. Nature Neuroscience 2019, 22: 840-841. PMID: 30760852, DOI: 10.1038/s41593-019-0356-9.
- Tang Y, Zhou Q, Chang M, Chekroud A, Gueorguieva R, Jiang X, Zhou Y, He G, Rowland M, Wang D, Fu S, Yin Z, Leng H, Wei S, Xu K, Wang F, Krystal JH, Driesen NR. Altered functional connectivity and low-frequency signal fluctuations in early psychosis and genetic high risk. Schizophrenia Research 2019, 210: 172-179. PMID: 30685394, DOI: 10.1016/j.schres.2018.12.041.
- Homan P, Levy I, Feltham E, Gordon C, Hu J, Li J, Pietrzak RH, Southwick S, Krystal JH, Harpaz-Rotem I, Schiller D. Neural computations of threat in the aftermath of combat trauma. Nature Neuroscience 2019, 22: 470-476. PMID: 30664770, PMCID: PMC6829910, DOI: 10.1038/s41593-018-0315-x.
- Tamman AJF, Montalvo-Ortiz JL, Southwick SM, Krystal JH, Levy BR, Pietrzak RH. Accelerated DNA Methylation Aging in U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study. American Journal Of Geriatric Psychiatry 2019, 27: 528-532. PMID: 30792041, DOI: 10.1016/j.jagp.2019.01.001.
- Abdallah CG, Averill CL, Ramage AE, Averill LA, Goktas S, Nemati S, Krystal JH, Roache JD, Resick PA, Young-McCaughan S, Peterson AL, Fox P, Consortium T. Salience Network Disruption in U.S. Army Soldiers With Posttraumatic Stress Disorder. Chronic Stress 2019, 3: 2470547019850467. PMID: 31131337, PMCID: PMC6529942, DOI: 10.1177/2470547019850467.
- Abdallah CG, Averill CL, Ramage AE, Averill LA, Alkin E, Nemati S, Krystal JH, Roache JD, Resick P, Young-McCaughan S, Peterson AL, Fox P, Consortium T. Reduced Salience and Enhanced Central Executive Connectivity Following PTSD Treatment. Chronic Stress 2019, 3: 2470547019838971. PMID: 31008419, PMCID: PMC6469713, DOI: 10.1177/2470547019838971.
- Zhang X, Hu Y, Aouizerat BE, Peng G, Marconi VC, Corley MJ, Hulgan T, Bryant KJ, Zhao H, Krystal JH, Justice AC, Xu K. Machine learning selected smoking-associated DNA methylation signatures that predict HIV prognosis and mortality. Clinical Epigenetics 2018, 10: 155. PMID: 30545403, PMCID: PMC6293604, DOI: 10.1186/s13148-018-0591-z.
- Zhornitsky S, Zhang S, Ide JS, Chao HH, Wang W, Le TM, Leeman RF, Bi J, Krystal JH, Li CR. Alcohol Expectancy and Cerebral Responses to Cue-Elicited Craving in Adult Nondependent Drinkers. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 4: 493-504. PMID: 30711509, PMCID: PMC6500759, DOI: 10.1016/j.bpsc.2018.11.012.
- Su TP, Chen MH, Li CT, Lin WC, Hong CJ, Gueorguieva R, Tu PC, Bai YM, Cheng CM, Krystal JH. Correction: Dose-Related Effects of Adjunctive Ketamine in Taiwanese Patients with Treatment-Resistant Depression. Neuropsychopharmacology 2018, 44: 655-656. PMID: 30487654, PMCID: PMC6333826, DOI: 10.1038/s41386-018-0253-z.
- Preller KH, Burt JB, Ji JL, Schleifer CH, Adkinson BD, Stämpfli P, Seifritz E, Repovs G, Krystal JH, Murray JD, Vollenweider FX, Anticevic A. Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor. ELife 2018, 7: e35082. PMID: 30355445, PMCID: PMC6202055, DOI: 10.7554/elife.35082.
- Zhornitsky S, Ide J, Wang W, Chao H, Zhang S, Hu S, Krystal J, Li C. Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult Drinkers. Brain Connectivity 2018, 8: 487-502. PMID: 30198312, PMCID: PMC6207153, DOI: 10.1089/brain.2018.0633.
- Pitts BL, Whealin JM, Harpaz-Rotem I, Duman RS, Krystal JH, Southwick SM, Pietrzak RH. BDNF Val66Met polymorphism and posttraumatic stress symptoms in U.S. military veterans: Protective effect of physical exercise. Psychoneuroendocrinology 2018, 100: 198-202. PMID: 30388593, DOI: 10.1016/j.psyneuen.2018.10.011.
- Zhou H, Cheng Z, Bass N, Krystal JH, Farrer LA, Kranzler HR, Gelernter J. Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression. Translational Psychiatry 2018, 8: 208. PMID: 30287806, PMCID: PMC6172277, DOI: 10.1038/s41398-018-0258-8.
- Chekroud SR, Gueorguieva R, Zheutlin AB, Paulus M, Krumholz HM, Krystal JH, Chekroud AM. Physical activity and mental health – Author's reply. The Lancet Psychiatry 2018, 5: 874. PMID: 30245184, DOI: 10.1016/s2215-0366(18)30354-7.
- Abdallah CG, Averill LA, Akiki TJ, Raza M, Averill CL, Gomaa H, Adikey A, Krystal JH. The Neurobiology and Pharmacotherapy of Posttraumatic Stress Disorder. The Annual Review Of Pharmacology And Toxicology 2018, 59: 171-189. PMID: 30216745, PMCID: PMC6326888, DOI: 10.1146/annurev-pharmtox-010818-021701.
- Akiki TJ, Averill CL, Wrocklage KM, Scott JC, Averill LA, Schweinsburg B, Alexander-Bloch A, Martini B, Southwick SM, Krystal JH, Abdallah CG. Topology of brain functional connectivity networks in posttraumatic stress disorder. Data In Brief 2018, 20: 1658-1675. PMID: 30364328, PMCID: PMC6195053, DOI: 10.1016/j.dib.2018.08.198.
- Krystal JH. Celebrating 50 Years of Biological Psychiatry: To the Future, and Beyond. Biological Psychiatry 2018, 85: 2-4. PMID: 30527209, DOI: 10.1016/j.biopsych.2018.08.015.
- Chekroud SR, Gueorguieva R, Zheutlin AB, Paulus M, Krumholz HM, Krystal JH, Chekroud AM. Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015: a cross-sectional study. The Lancet Psychiatry 2018, 5: 739-746. PMID: 30099000, DOI: 10.1016/s2215-0366(18)30227-x.
- Nardi AE, Cosci F, Balon R, Weintraub SJ, Freire RC, Krystal JH, Roth T, Silberman EK, Sonino N, Fava GA, Starcevic V, Dubovsky SL, Salzman C, Rickels K, Greenblatt DJ, Shader RI, Chouinard G. The Prescription of Benzodiazepines for Panic Disorder. Journal Of Clinical Psychopharmacology 2018, 38: 283-285. PMID: 29912790, DOI: 10.1097/jcp.0000000000000908.
- Averill CL, Averill LA, Wrocklage KM, Scott JC, Akiki TJ, Schweinsburg B, Southwick SM, Krystal JH, Abdallah CG. Altered White Matter Diffusivity of the Cingulum Angular Bundle in Posttraumatic Stress Disorder. Complex Psychiatry 2018, 4: 75-82. PMID: 30397595, PMCID: PMC6206974, DOI: 10.1159/000490464.
- Chekroud AM, Foster D, Zheutlin AB, Gerhard DM, Roy B, Koutsouleris N, Chandra A, Esposti MD, Subramanyan G, Gueorguieva R, Paulus M, Krystal JH. Predicting Barriers to Treatment for Depression in a U.S. National Sample: A Cross-Sectional, Proof-of-Concept Study. Psychiatric Services 2018, 69: 927-934. PMID: 29962307, PMCID: PMC7232987, DOI: 10.1176/appi.ps.201800094.
- Abdallah CG, De Feyter HM, Averill LA, Jiang L, Averill CL, Chowdhury GMI, Purohit P, de Graaf RA, Esterlis I, Juchem C, Pittman BP, Krystal JH, Rothman DL, Sanacora G, Mason GF. The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects. Neuropsychopharmacology 2018, 43: 2154-2160. PMID: 29977074, PMCID: PMC6098048, DOI: 10.1038/s41386-018-0136-3.
- Zhang X, Zhang X, Hu Y, Justice A, Li B, Wang Z, Zhao H, Krystal J, Xu K. DNA methylation signatures analysis with Illumina Infinitum MethylationEPIC and Infinium Human Methylation 450K BeadChip. Protocol Exchange 2018 DOI: 10.1038/protex.2018.080.
- Abdallah CG, Sanacora G, Duman RS, Krystal JH. The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation? Pharmacology & Therapeutics 2018, 190: 148-158. PMID: 29803629, PMCID: PMC6165688, DOI: 10.1016/j.pharmthera.2018.05.010.
- Balon R, Chouinard G, Cosci F, Dubovsky SL, Fava GA, Freire RC, Greenblatt DJ, Krystal JH, Nardi AE, Rickels K, Roth T, Salzman C, Shader R, Silberman EK, Sonino N, Starcevic V, Weintraub SJ. International Task Force on Benzodiazepines. Psychotherapy And Psychosomatics 2018, 87: 193-194. PMID: 29788029, DOI: 10.1159/000489538.
- Wilkinson S, Ostroff R, Katz R, Krystal J. Erratum to: Ketamine: A Promising Rapid-Acting Antidepressant. 2018, e1-e1. DOI: 10.1007/978-981-10-6577-4_24.
- Ide JS, Zhornitsky S, Chao HH, Zhang S, Hu S, Wang W, Krystal JH, Li CR. Thalamic Cortical Error–Related Responses in Adult Social Drinkers: Sex Differences and Problem Alcohol Use. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 3: 868-877. PMID: 29859929, PMCID: PMC6177312, DOI: 10.1016/j.bpsc.2018.04.008.
- Akiki TJ, Averill CL, Wrocklage KM, Scott JC, Averill LA, Schweinsburg B, Alexander-Bloch A, Martini B, Southwick SM, Krystal JH, Abdallah CG. Default mode network abnormalities in posttraumatic stress disorder: A novel network-restricted topology approach. NeuroImage 2018, 176: 489-498. PMID: 29730491, PMCID: PMC5976548, DOI: 10.1016/j.neuroimage.2018.05.005.
- Cho Y, Schleifer C, Moujaes F, Starc M, Ji J, Santamauro N, Adkinson B, Lituchy M, Krystal J, Murray J, Repovs G, Anticevic A. S232. Effects of Incentive Presentation on Spatial Working Memory Performance. Biological Psychiatry 2018, 83: s438. DOI: 10.1016/j.biopsych.2018.02.1124.
- Girgenti M, Cruz D, Williamson D, Friedman M, Krystal J, Duman R. T103. Transcriptome Alterations for Posttraumatic Stress Disorder in Human Prefrontal Cortex. Biological Psychiatry 2018, 83: s168. DOI: 10.1016/j.biopsych.2018.02.439.
- Zhou H, Zhong Z, Bass N, Krystal J, Farrer L, Kranzler H, Gelernter J. F131. Genome-Wide Association Study Identifies Glutamate Ionotropic Receptor GRIA4 as a Risk Gene for Comorbid Nicotine Dependence and Major Depression. Biological Psychiatry 2018, 83: s288-s289. DOI: 10.1016/j.biopsych.2018.02.744.
- Kegeles LS, Horga G, Ghazzaoui R, Rosengard R, Ojeil N, Xu X, Slifstein M, Petrakis I, O’Malley S, Krystal JH, Abi-Dargham A. Enhanced Striatal Dopamine Release to Expectation of Alcohol: A Potential Risk Factor for Alcohol Use Disorder. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 3: 591-598. PMID: 29803635, PMCID: PMC6953614, DOI: 10.1016/j.bpsc.2018.03.018.
- Fuehrlein BS, Kachadourian LK, DeVylder EK, Trevisan LA, Potenza MN, Krystal JH, Southwick SM, Pietrzak RH. Trajectories of alcohol consumption in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. American Journal On Addictions 2018, 27: 383-390. PMID: 29667712, DOI: 10.1111/ajad.12731.
- Krystal J. 2. MICROCIRCUITS, MACROCIRCUITS, AND CORTICOL DYSFUNCTION IN SCHIZOPHRENIA: A COMPUTATIONAL AND TRANSLATIONAL NEUROSCIENCE PERSPECTIVE. Schizophrenia Bulletin 2018, 44: s1-s1. PMCID: PMC5887654, DOI: 10.1093/schbul/sby014.001.
- Morean ME, DeMartini KS, Foster D, Patock-Peckham J, Garrison KA, Corlett PR, Krystal JH, Krishan-Sarin S, O'Malley SS. The Self-Report Habit Index: Assessing habitual marijuana, alcohol, e-cigarette, and cigarette use. Drug And Alcohol Dependence 2018, 186: 207-214. PMID: 29609132, PMCID: PMC5912163, DOI: 10.1016/j.drugalcdep.2018.01.014.
- Cheng WJ, Chen CH, Chen CK, Huang MC, Pietrzak RH, Krystal JH, Xu K. Similar psychotic and cognitive profile between ketamine dependence with persistent psychosis and schizophrenia. Schizophrenia Research 2018, 199: 313-318. PMID: 29510925, DOI: 10.1016/j.schres.2018.02.049.
- Krystal JH, Abdallah CG, Pietrzak RH, Averill LA, Harpaz-Rotem I, Levy I, Kelmendi B, Southwick SM. Locus Coeruleus Hyperactivity in Posttraumatic Stress Disorder: Answers and Questions. Biological Psychiatry 2018, 83: 197-199. PMID: 29277190, DOI: 10.1016/j.biopsych.2017.09.027.
- D’Souza D, Carson RE, Driesen N, Johannesen J, Ranganathan M, Krystal JH, Ahn K, Bielen K, Carbuto M, Deaso E, D’Souza D, Ranganathan M, Naganawa M, Ranganathan M, D’Souza D, Nabulsi N, Zheng M, Lin S, Huang Y, Carson R, Driesen N, Ahn K, Morgan P, Suckow R, He G, McCarthy G, Krystal J, Johannesen J, Kenney J, Gelernter J, Gueorguieva R, Pittman B. Dose-Related Target Occupancy and Effects on Circuitry, Behavior, and Neuroplasticity of the Glycine Transporter-1 Inhibitor PF-03463275 in Healthy and Schizophrenia Subjects. Biological Psychiatry 2018, 84: 413-421. PMID: 29499855, PMCID: PMC6068006, DOI: 10.1016/j.biopsych.2017.12.019.
- Anticevic A, Krystal J, Murray J. Meeting Emerging Challenges and Opportunities in Psychiatry Through Computational Neuroscience. 2018, xiii-xxxi. DOI: 10.1016/b978-0-12-809825-7.02004-6.
- Chekroud AM, Loho H, Paulus M, Krystal JH. PTSD and the War of Words. Chronic Stress 2018, 2: 2470547018767387. PMID: 32440582, PMCID: PMC7219886, DOI: 10.1177/2470547018767387.
- Javitt DC, Carter CS, Krystal JH, Kantrowitz JT, Girgis RR, Kegeles LS, Ragland JD, Maddock RJ, Lesh TA, Tanase C, Corlett PR, Rothman DL, Mason G, Qiu M, Robinson J, Potter WZ, Carlson M, Wall MM, Choo TH, Grinband J, Lieberman JA. Utility of Imaging-Based Biomarkers for Glutamate-Targeted Drug Development in Psychotic Disorders: A Randomized Clinical Trial. JAMA Psychiatry 2018, 75: 11-19. PMID: 29167877, PMCID: PMC5833531, DOI: 10.1001/jamapsychiatry.2017.3572.
- Holmes SE, Scheinost D, DellaGioia N, Davis MT, Matuskey D, Pietrzak RH, Hampson M, Krystal JH, Esterlis I. Cerebellar and Prefrontal Cortical Alterations in PTSD: Structural and Functional Evidence. Chronic Stress 2018, 2: 2470547018786390. PMID: 30035247, PMCID: PMC6054445, DOI: 10.1177/2470547018786390.
- DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailtyZhang X, Hu Y, Justice AC, Li B, Wang Z, Zhao H, Krystal JH, Xu K. DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailty. Nature Communications 2017, 8: 2243. PMID: 29269866, PMCID: PMC5740109, DOI: 10.1038/s41467-017-02326-1.
- Byrne SP, Krystal JH, Rosenheck RA, Vessicchio J, Pietrzak RH. Correlates of Nonimprovement to Pharmacotherapy for Chronic, Antidepressant-Resistant, Military Service–Related Posttraumatic Stress Disorder. Journal Of Clinical Psychopharmacology 2017, 37: 717-721. PMID: 28945664, DOI: 10.1097/jcp.0000000000000777.
- Mota NP, Han S, Harpaz‐Rotem I, Maruff P, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH. Apolipoprotein E gene polymorphism, trauma burden, and posttraumatic stress symptoms in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Depression And Anxiety 2017, 35: 168-177. PMID: 29172227, PMCID: PMC5794529, DOI: 10.1002/da.22698.
- Zhang X, Zhang X, Hu Y, Justice A, Li B, Wang Z, Zhao H, Krystal J, Xu K. DNA methylation signatures analysis with Illumina Infinitum MethylationEPIC and Infinium Human Methylation 450K BeadChip. Protocol Exchange 2017 DOI: 10.1038/protex.2017.135.
- Yang B, Arias AJ, Feinn R, Krystal JH, Gelernter J, Petrakis IL. GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose‐Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers. Alcohol Clinical And Experimental Research 2017, 41: 2025-2032. PMID: 29131352, PMCID: PMC5764175, DOI: 10.1111/acer.13516.
- Andersen AM, Pietrzak RH, Kranzler HR, Ma L, Zhou H, Liu X, Kramer J, Kuperman S, Edenberg HJ, Nurnberger JI, Rice JP, Tischfield JA, Goate A, Foroud TM, Meyers JL, Porjesz B, Dick DM, Hesselbrock V, Boerwinkle E, Southwick SM, Krystal JH, Weissman MM, Levinson DF, Potash JB, Gelernter J, Han S. Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence. JAMA Psychiatry 2017, 74: 1153-1160. PMID: 28813562, PMCID: PMC5710224, DOI: 10.1001/jamapsychiatry.2017.2269.
- Watkins LE, Han S, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH. Association Between Functional Polymorphism in Neuropeptide Y Gene Promoter rs16147 and Resilience to Traumatic Stress in US Military Veterans. The Journal Of Clinical Psychiatry 2017, 78: e1058-e1059. PMID: 29099554, DOI: 10.4088/jcp.17l11646.
- Wilkinson S, Ostroff R, Katz R, Krystal J. Ketamine: A Promising Rapid-Acting Antidepressant. 2017, 223-239. DOI: 10.1007/978-981-10-6577-4_16.
- Krystal J. My Path to Psychiatry. Psychiatric News 2017, 52: 1-1. DOI: 10.1176/appi.pn.2017.10b1.
- Krystal JH, Davis LL, Neylan TC, Raskind M, Schnurr PP, Stein MB, Vessicchio J, Shiner B, Gleason TC, Huang GD. Reply to: It Is Time to Look for New Treatments for Posttraumatic Stress Disorder: Can Sympathetic System Modulation Be an Answer? Biological Psychiatry 2017, 84: e19-e20. PMID: 29132654, DOI: 10.1016/j.biopsych.2017.09.031.
- Petrakis IL, Ralevski E, Gueorguieva R, O'Malley SS, Arias A, Sevarino KA, Jane JS, O'Brien E, Krystal JH. Mecamylamine treatment for alcohol dependence: a randomized controlled trial. Addiction 2017, 113: 6-14. PMID: 28710873, PMCID: PMC5725262, DOI: 10.1111/add.13943.
- Tamman AJF, Sippel LM, Han S, Neria Y, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH. Attachment style moderates effects of FKBP5 polymorphisms and childhood abuse on post-traumatic stress symptoms: Results from the National Health and Resilience in Veterans Study. The World Journal Of Biological Psychiatry 2017, 20: 289-300. PMID: 28891785, DOI: 10.1080/15622975.2017.1376114.
- Krystal J. KL.01.01 Targeting glutamate in psychiatric disease. European Neuropsychopharmacology 2017, 27: s521. DOI: 10.1016/s0924-977x(17)30985-9.
- Abdallah CG, Averill CL, Salas R, Averill LA, Baldwin PR, Krystal JH, Mathew SJ, Mathalon DH. Prefrontal Connectivity and Glutamate Transmission: Relevance to Depression Pathophysiology and Ketamine Treatment. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2017, 2: 566-574. PMID: 29034354, PMCID: PMC5635826, DOI: 10.1016/j.bpsc.2017.04.006.
- Taylor JJ, Krystal JH, D'Souza DC, Gerrard JL, Corlett PR. Targeted neural network interventions for auditory hallucinations: Can TMS inform DBS? Schizophrenia Research 2017, 195: 455-462. PMID: 28969932, PMCID: PMC8141945, DOI: 10.1016/j.schres.2017.09.020.
- Scheinost D, Holmes SE, DellaGioia N, Schleifer C, Matuskey D, Abdallah CG, Hampson M, Krystal JH, Anticevic A, Esterlis I. Multimodal Investigation of Network Level Effects Using Intrinsic Functional Connectivity, Anatomical Covariance, and Structure-to-Function Correlations in Unmedicated Major Depressive Disorder. Neuropsychopharmacology 2017, 43: 1119-1127. PMID: 28944772, PMCID: PMC5854800, DOI: 10.1038/npp.2017.229.
- Logue MW, van Rooij SJH, Dennis EL, Davis SL, Hayes JP, Stevens JS, Densmore M, Haswell CC, Ipser J, Koch SBJ, Korgaonkar M, Lebois LAM, Peverill M, Baker JT, Boedhoe PSW, Frijling JL, Gruber SA, Harpaz-Rotem I, Jahanshad N, Koopowitz S, Levy I, Nawijn L, O’Connor L, Olff M, Salat DH, Sheridan MA, Spielberg JM, van Zuiden M, Winternitz SR, Wolff JD, Wolf EJ, Wang X, Wrocklage K, Abdallah CG, Bryant RA, Geuze E, Jovanovic T, Kaufman ML, King AP, Krystal JH, Lagopoulos J, Bennett M, Lanius R, Liberzon I, McGlinchey RE, McLaughlin KA, Milberg WP, Miller MW, Ressler KJ, Veltman DJ, Stein DJ, Thomaes K, Thompson PM, Morey RA. Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia. Biological Psychiatry 2017, 83: 244-253. PMID: 29217296, PMCID: PMC5951719, DOI: 10.1016/j.biopsych.2017.09.006.
- Esterlis I, Holmes SE, Sharma P, Krystal JH, DeLorenzo C. Metabotropic Glutamatergic Receptor 5 and Stress Disorders: Knowledge Gained From Receptor Imaging Studies. Biological Psychiatry 2017, 84: 95-105. PMID: 29100629, PMCID: PMC5858955, DOI: 10.1016/j.biopsych.2017.08.025.
- Krystal JH. Biological Psychiatry: A New Approach to Reviews. Biological Psychiatry 2017, 82: 620. PMID: 28918940, DOI: 10.1016/j.biopsych.2017.07.025.
- Kelmendi B, Adams TG, Southwick S, Abdallah CG, Krystal JH. Posttraumatic Stress Disorder: An Integrated Overview of the Neurobiological Rationale for Pharmacology. Clinical Psychology Science And Practice 2017, 24: 281-297. PMID: 31404451, PMCID: PMC6688474, DOI: 10.1111/cpsp.12202.
- Krystal JH, Abdallah CG, Averill LA, Kelmendi B, Harpaz-Rotem I, Sanacora G, Southwick SM, Duman RS. Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic. Current Psychiatry Reports 2017, 19: 74. PMID: 28844076, PMCID: PMC5904792, DOI: 10.1007/s11920-017-0829-z.
- Holmes SE, Girgenti MJ, Davis MT, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Duman RS, Carson RE, Krystal JH, Esterlis I, Friedman M, Kowall N, Brady C, McKee A, Stein T, Huber B, Kaloupek D, Alvarez V, Benedek D, Ursano R, Williamson D, Cruz D, Young K, Duman R, Krystal J, Mash D, Hardegree M, Serlin G. Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 8390-8395. PMID: 28716937, PMCID: PMC5547601, DOI: 10.1073/pnas.1701749114.
- Sippel LM, Han S, Watkins LE, Harpaz-Rotem I, Southwick SM, Krystal JH, Olff M, Sherva R, Farrer LA, Kranzler HR, Gelernter J, Pietrzak RH. Oxytocin receptor gene polymorphisms, attachment, and PTSD: Results from the National Health and Resilience in Veterans Study. Journal Of Psychiatric Research 2017, 94: 139-147. PMID: 28715704, PMCID: PMC5605420, DOI: 10.1016/j.jpsychires.2017.07.008.
- Wisco BE, Marx BP, Miller MW, Wolf EJ, Krystal JH, Southwick SM, Pietrzak RH. A comparison of ICD-11 and DSM criteria for posttraumatic stress disorder in two national samples of U.S. military veterans. Journal Of Affective Disorders 2017, 223: 17-19. PMID: 28715723, DOI: 10.1016/j.jad.2017.07.006.
- Stefanovics EA, Rosenheck RA, Jones KM, Huang G, Krystal JH. Minimal Clinically Important Differences (MCID) in Assessing Outcomes of Post-Traumatic Stress Disorder. Psychiatric Quarterly 2017, 89: 141-155. PMID: 28634644, DOI: 10.1007/s11126-017-9522-y.
- Su TP, Chen MH, Li CT, Lin WC, Hong CJ, Gueorguieva R, Tu PC, Bai YM, Cheng CM, Krystal JH. Dose-Related Effects of Adjunctive Ketamine in Taiwanese Patients with Treatment-Resistant Depression. Neuropsychopharmacology 2017, 42: 2482-2492. PMID: 28492279, PMCID: PMC5686503, DOI: 10.1038/npp.2017.94.
- Cho Y, Schleifer C, Starc M, Ji J, Santamauro N, Adkinson B, Lituchy M, Krystal J, Murray J, Repovs G, Anticevic A. 961 Incentives to Perform: The Effects of Reward on Working Memory. Biological Psychiatry 2017, 81: s389. DOI: 10.1016/j.biopsych.2017.02.687.
- Cortes-Briones J, Skosnik P, D’Souza D, Abdallah C, Petrakis I, Krystal J. 67 Ketamine-induced Changes in Neural Noise and their Relationship to Psychosis-like Symptoms. Biological Psychiatry 2017, 81: s28. DOI: 10.1016/j.biopsych.2017.02.078.
- Morey R, Logue M, van Rooij S, Dennis E, Davis S, Hayes J, Stevens J, Densmore M, Koch S, Korgaonkar M, LeBois L, Peverill M, Jahanshad N, Lagopoulos J, Gueze E, Jovanovic T, Abdallah C, Bennett M, King A, Krystal J, Bryant R, Miller M, Veltman D, McLaughlin K, Lanius R, Stein D, Thomaes K, Liberzon I, Ressler K, Thompson P. 87 Volume of Sub-Cortical Structures in Posttraumatic Stress Disorder from Multi-Site Investigation by ENIGMA and PGC Consortia. Biological Psychiatry 2017, 81: s36-s37. DOI: 10.1016/j.biopsych.2017.02.099.
- Ferri J, Ford J, Roach B, Perry-O׳Leary D, Jaeger J, Gunduz-Bruce H, Krystal J, Mathalon D. 539 Ketamine, an NMDA-Receptor Antagonist, Mimics the Patterns of Intrinsically but Not Extrinsically Driven Gamma Oscillations. Biological Psychiatry 2017, 81: s218-s219. DOI: 10.1016/j.biopsych.2017.02.1147.
- Akiki T, Averill C, Wrocklage K, Scott J, Alexander-Bloch A, Southwick S, Krystal J, Abdallah C. 581 The Default Mode Network in Posttraumatic Stress Disorder (PTSD): A Data-Driven Multimodal Approach. Biological Psychiatry 2017, 81: s235. DOI: 10.1016/j.biopsych.2017.02.451.
- Hamilton H, Kort N, Ford J, Roach B, Gunduz-Bruce H, Krystal J, Jaeger J, Reinhart R, Mathalon D. 540 Effects of N-methyl-D-aspartate Glutamate Receptor Disruption and Nicotinic Acetylcholine Enhancement on Mismatch Negativity. Biological Psychiatry 2017, 81: s219. DOI: 10.1016/j.biopsych.2017.02.1148.
- Anticevic A, Schleifer C, Srihari V, Krystal J, Murray J, Repovs G, Xu G, Ji L, Cho Y, Santamauro N, Foss-Feig J, Yang G, Morgan P, Savic A. 423 NMDAR Antagonism via Ketamine Differentially Modulates Thalamic versus Hippocampal Functional Connectivity. Biological Psychiatry 2017, 81: s172-s173. DOI: 10.1016/j.biopsych.2017.02.907.
- Esterlis I, Pietrzak R, DellaGioia N, Matuskey D, Huang H, Krystal J, Duman R, Carson R, Finnema S. 389 In Vivo Evidence of Lower Synaptic Density in Depression and Associated Mood and Cognitive Deficits: A [11C]UCB-J PET Imaging Study. Biological Psychiatry 2017, 81: s159. DOI: 10.1016/j.biopsych.2017.02.406.
- Davis M, Holmes S, Pietrzak R, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Carson R, Krystal J, Esterlis I. 18 In Vivo Quantification of mGluR5 Availability in Posttraumatic Stress Disorder. Biological Psychiatry 2017, 81: s8. DOI: 10.1016/j.biopsych.2017.02.029.
- Preller K, Schleifer C, Stämpfli P, Krystal J, Vollenweider F, Anticevic A. 951 Changes in Resting-State Global Brain Connectivity in LSD-Induced Altered States of Consciousness are Attributable to the 5-HT2A Receptor. Biological Psychiatry 2017, 81: s385. DOI: 10.1016/j.biopsych.2017.02.677.
- Abdallah CG, Southwick SM, Krystal JH. Neurobiology of posttraumatic stress disorder (PTSD): A path from novel pathophysiology to innovative therapeutics. Neuroscience Letters 2017, 649: 130-132. PMID: 28478864, DOI: 10.1016/j.neulet.2017.04.046.
- Esterlis I, DellaGioia N, Pietrzak RH, Matuskey D, Nabulsi N, Abdallah CG, Yang J, Pittenger C, Sanacora G, Krystal JH, Parsey RV, Carson RE, DeLorenzo C. Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression. Molecular Psychiatry 2017, 23: 824-832. PMID: 28397841, PMCID: PMC5636649, DOI: 10.1038/mp.2017.58.
- Chekroud AM, Gueorguieva R, Krumholz HM, Trivedi MH, Krystal JH, McCarthy G. Reevaluating the Efficacy and Predictability of Antidepressant Treatments: A Symptom Clustering Approach. JAMA Psychiatry 2017, 74: 370-378. PMID: 28241180, PMCID: PMC5863470, DOI: 10.1001/jamapsychiatry.2017.0025.
- Chekroud AM, Loho H, Krystal JH. Mental illness and mental health. The Lancet Psychiatry 2017, 4: 276-277. PMID: 28347431, DOI: 10.1016/s2215-0366(17)30088-3.
- Ide JS, Zhornitsky S, Hu S, Zhang S, Krystal JH, Li CR. Sex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study. NeuroImage Clinical 2017, 14: 750-759. PMID: 28413777, PMCID: PMC5385596, DOI: 10.1016/j.nicl.2017.03.015.
- Wisco BE, Marx BP, May CL, Martini B, Krystal JH, Southwick SM, Pietrzak RH. Moral injury in U.S. combat veterans: Results from the national health and resilience in veterans study. Depression And Anxiety 2017, 34: 340-347. PMID: 28370818, DOI: 10.1002/da.22614.
- Posttraumatic symptom profiles among adult survivors of childhood sexual abuse: A longitudinal studySteine IM, Winje D, Skogen JC, Krystal JH, Milde AM, Bjorvatn B, Nordhus IH, Grønli J, Pallesen S. Posttraumatic symptom profiles among adult survivors of childhood sexual abuse: A longitudinal study. Child Abuse & Neglect 2017, 67: 280-293. PMID: 28327414, DOI: 10.1016/j.chiabu.2017.03.002.
- Foss-Feig JH, Adkinson BD, Ji JL, Yang G, Srihari VH, McPartland JC, Krystal JH, Murray JD, Anticevic A. Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders. Biological Psychiatry 2017, 81: 848-861. PMID: 28434615, PMCID: PMC5436134, DOI: 10.1016/j.biopsych.2017.03.005.
- Krystal JH, Davis LL, Neylan TC, Raskind M, Schnurr PP, Stein MB, Vessicchio J, Shiner B, Gleason TD, Huang GD. It Is Time to Address the Crisis in the Pharmacotherapy of Posttraumatic Stress Disorder: A Consensus Statement of the PTSD Psychopharmacology Working Group. Biological Psychiatry 2017, 82: e51-e59. PMID: 28454621, DOI: 10.1016/j.biopsych.2017.03.007.
- Krystal JH, Murray JD, Chekroud AM, Corlett PR, Yang G, Wang XJ, Anticevic A. Computational Psychiatry and the Challenge of Schizophrenia. Schizophrenia Bulletin 2017, 43: 473-475. PMID: 28338845, PMCID: PMC5464204, DOI: 10.1093/schbul/sbx025.
- Wrocklage KM, Averill LA, Scott J, Averill CL, Schweinsburg B, Trejo M, Roy A, Weisser V, Kelly C, Martini B, Harpaz-Rotem I, Southwick SM, Krystal JH, Abdallah CG. Cortical thickness reduction in combat exposed U.S. veterans with and without PTSD. European Neuropsychopharmacology 2017, 27: 515-525. PMID: 28279623, PMCID: PMC5429865, DOI: 10.1016/j.euroneuro.2017.02.010.
- Abdallah CG, Wrocklage KM, Averill CL, Akiki T, Schweinsburg B, Roy A, Martini B, Southwick SM, Krystal JH, Scott JC. Anterior hippocampal dysconnectivity in posttraumatic stress disorder: a dimensional and multimodal approach. Translational Psychiatry 2017, 7: e1045-e1045. PMID: 28244983, PMCID: PMC5545643, DOI: 10.1038/tp.2017.12.
- Abdallah CG, Averill LA, Krystal JH. A New Journal: Addressing the Behavioral and Biological Effects of Chronic Stress. Chronic Stress 2017, 1: 2470547016683296. PMID: 32440577, PMCID: PMC7219917, DOI: 10.1177/2470547016683296.
- Goldenberg MN, Krystal JH. Undergraduate Neuroscience Majors: A Missed Opportunity for Psychiatry Workforce Development. Academic Psychiatry 2017, 41: 239-242. PMID: 28188505, DOI: 10.1007/s40596-017-0670-z.
- Gueorguieva R, Chekroud AM, Krystal JH. Trajectories of relapse in randomised, placebo-controlled trials of treatment discontinuation in major depressive disorder: an individual patient-level data meta-analysis. The Lancet Psychiatry 2017, 4: 230-237. PMID: 28189575, PMCID: PMC5340978, DOI: 10.1016/s2215-0366(17)30038-x.
- Averill LA, Abdallah CG, Pietrzak RH, Averill CL, Southwick SM, Krystal JH, Harpaz-Rotem I. Combat Exposure Severity Is Associated With Reduced Cortical Thickness in Combat Veterans: A Preliminary Report. Chronic Stress 2017, 1: 2470547017724714. PMID: 28845475, PMCID: PMC5568834, DOI: 10.1177/2470547017724714.
- Averill CL, Satodiya RM, Scott JC, Wrocklage KM, Schweinsburg B, Averill LA, Akiki TJ, Amoroso T, Southwick SM, Krystal JH, Abdallah CG. Posttraumatic Stress Disorder and Depression Symptom Severities Are Differentially Associated With Hippocampal Subfield Volume Loss in Combat Veterans. Chronic Stress 2017, 1: 2470547017744538. PMID: 29520395, PMCID: PMC5839647, DOI: 10.1177/2470547017744538.
- Akiki TJ, Averill CL, Wrocklage KM, Schweinsburg B, Scott JC, Martini B, Averill LA, Southwick SM, Krystal JH, Abdallah CG. The Association of PTSD Symptom Severity With Localized Hippocampus and Amygdala Abnormalities. Chronic Stress 2017, 1: 2470547017724069. PMID: 28825050, PMCID: PMC5562232, DOI: 10.1177/2470547017724069.
- Chang F, Xu K, Huang MC, Krystal JH. Alcohol Triggers Reemergence of Ketamine-Like Experience in a Ketamine Ex-User. Journal Of Clinical Psychopharmacology 2017, 37: 110-112. PMID: 28027112, PMCID: PMC5193231, DOI: 10.1097/jcp.0000000000000635.
- Krystal JH, Petrakis IL, O’Malley S, Krishnan-Sarin S, Pearlson G, Yoon G. NMDA Glutamate Receptor Antagonism and the Heritable Risk for Alcoholism: New Insights from a Study of Nitrous Oxide. The International Journal Of Neuropsychopharmacology 2017, 20: 351-353. PMID: 28158462, PMCID: PMC5409033, DOI: 10.1093/ijnp/pyw118.
- Steine IM, Winje D, Krystal JH, Bjorvatn B, Milde AM, Grønli J, Nordhus IH, Pallesen S. Cumulative childhood maltreatment and its dose-response relation with adult symptomatology: Findings in a sample of adult survivors of sexual abuse. Child Abuse & Neglect 2017, 65: 99-111. PMID: 28131947, DOI: 10.1016/j.chiabu.2017.01.008.
- Krystal JH, Anticevic A, Yang GJ, Dragoi G, Driesen NR, Wang XJ, Murray JD. Impaired Tuning of Neural Ensembles and the Pathophysiology of Schizophrenia: A Translational and Computational Neuroscience Perspective. Biological Psychiatry 2017, 81: 874-885. PMID: 28434616, PMCID: PMC5407407, DOI: 10.1016/j.biopsych.2017.01.004.
- Steine IM, Zayats T, Stansberg C, Pallesen S, Mrdalj J, Håvik B, Soulé J, Haavik J, Milde AM, Skrede S, Murison R, Krystal J, Grønli J. Implication of NOTCH1 gene in susceptibility to anxiety and depression among sexual abuse victims. Translational Psychiatry 2016, 6: e977-e977. PMID: 27959334, PMCID: PMC5290341, DOI: 10.1038/tp.2016.248.
- Krystal J, Anticevic A, Murray J, Glahn D, Driesen N, Yang G, Wang X. Clinical Heterogeneity Arising from Categorical and Dimensional Features of the Neurobiology of Psychiatric Diagnoses: Insights from Neuroimaging and Computational Neuroscience. 2016, 293-316. DOI: 10.7551/mitpress/10936.003.0023.
- Averill LA, Purohit P, Averill CL, Boesl MA, Krystal JH, Abdallah CG. Glutamate dysregulation and glutamatergic therapeutics for PTSD: Evidence from human studies. Neuroscience Letters 2016, 649: 147-155. PMID: 27916636, PMCID: PMC5482215, DOI: 10.1016/j.neulet.2016.11.064.
- Kelmendi B, Corlett P, Ranganathan M, D’Souza C, Krystal JH. The role of psychedelics in palliative care reconsidered: A case for psilocybin. Journal Of Psychopharmacology 2016, 30: 1212-1214. PMID: 27909173, DOI: 10.1177/0269881116675781.
- Krystal J, Anticevic A, Murray J, Glahn D, Driesen N, Yang G, Wang X. Clinical Heterogeneity Arising from Categorical and Dimensional Features of the Neurobiology of Psychiatric Diagnoses. 2016 DOI: 10.7551/mitpress/9780262035422.003.0016.
- Yehuda R, Spiegel D, Southwick S, Davis LL, Neylan TC, Krystal JH. What I have changed my mind about and why. European Journal Of Psychotraumatology 2016, 7: 33768. PMID: 27837585, PMCID: PMC5106864, DOI: 10.3402/ejpt.v7.33768.
- Kelmendi B, Adams TG, Yarnell S, Southwick S, Abdallah CG, Krystal JH. PTSD: from neurobiology to pharmacological treatments. European Journal Of Psychotraumatology 2016, 7: 31858. PMID: 27837583, PMCID: PMC5106865, DOI: 10.3402/ejpt.v7.31858.
- Khlestova E, Johnson JW, Krystal JH, Lisman J. The Role of GluN2C-Containing NMDA Receptors in Ketamine's Psychotogenic Action and in Schizophrenia Models. Journal Of Neuroscience 2016, 36: 11151-11157. PMID: 27807157, PMCID: PMC5148234, DOI: 10.1523/jneurosci.1203-16.2016.
- Isaacs K, Mota NP, Tsai J, Harpaz-Rotem I, Cook JM, Kirwin PD, Krystal JH, Southwick SM, Pietrzak RH. Psychological resilience in U.S. military veterans: A 2-year, nationally representative prospective cohort study. Journal Of Psychiatric Research 2016, 84: 301-309. PMID: 27814502, DOI: 10.1016/j.jpsychires.2016.10.017.
- Starc M, Murray JD, Santamauro N, Savic A, Diehl C, Cho YT, Srihari V, Morgan PT, Krystal JH, Wang XJ, Repovs G, Anticevic A. Schizophrenia is associated with a pattern of spatial working memory deficits consistent with cortical disinhibition. Schizophrenia Research 2016, 181: 107-116. PMID: 27745755, PMCID: PMC5901719, DOI: 10.1016/j.schres.2016.10.011.
- Yang GJ, Murray JD, Glasser M, Pearlson GD, Krystal JH, Schleifer C, Repovs G, Anticevic A. Altered Global Signal Topography in Schizophrenia. Cerebral Cortex 2016, 27: 5156-5169. PMID: 27702810, PMCID: PMC6075538, DOI: 10.1093/cercor/bhw297.
- Steiner JL, Anez-Nava L, Baranoski M, Cole R, Davidson L, Delphin-Rittmon M, Dike C, DiLeo PJ, Duman RS, Kirk T, Krystal J, Malison RT, Rohrbaugh RM, Sernyak MJ, Srihari V, Styron T, Tebes JK, Woods S, Zonana H, Jacobs SC. The Connecticut Mental Health Center: Celebrating 50 Years of a Successful Partnership Between the State and Yale University. Psychiatric Services 2016, 67: 1286-1289. PMID: 27691379, DOI: 10.1176/appi.ps.201600373.
- Mukamal KJ, Clowry CM, Murray MM, Hendriks HF, Rimm EB, Sink KM, Adebamowo CA, Dragsted LO, Lapinski PS, Lazo M, Krystal JH. Moderate Alcohol Consumption and Chronic Disease: The Case for a Long‐Term Trial. Alcohol Clinical And Experimental Research 2016, 40: 2283-2291. PMID: 27688006, PMCID: PMC5073014, DOI: 10.1111/acer.13231.
- Zhang X, Justice AC, Hu Y, Wang Z, Zhao H, Wang G, Johnson EO, Emu B, Sutton RE, Krystal JH, Xu K. Epigenome-wide differential DNA methylation between HIV-infected and uninfected individuals. Epigenetics 2016, 11: 750-760. PMID: 27672717, PMCID: PMC5094631, DOI: 10.1080/15592294.2016.1221569.
- Knickman J, Krishnan K, Pincus H, Blanco C, Blazer D, Coye M, Krystal J, Rauch S, Simon G, Vitiello B. Improving Access to Effective Care for People Who Have Mental Health and Substance Use Disorders: A Vital Direction for Health and Health Care. NAM Perspectives 2016, 6 DOI: 10.31478/201609v.
- Pietrzak RH, Zhu Y, Slade MD, Qi Q, Krystal JH, Southwick SM, Levy BR. Association Between Negative Age Stereotypes and Accelerated Cellular Aging: Evidence from Two Cohorts of Older Adults. Journal Of The American Geriatrics Society 2016, 64: e228-e230. PMID: 27641354, PMCID: PMC5118148, DOI: 10.1111/jgs.14452.
- Watkins LE, Harpaz-Rotem I, Sippel LM, Krystal JH, Southwick SM, Pietrzak RH. Hostility and telomere shortening among U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Psychoneuroendocrinology 2016, 74: 251-257. PMID: 27689898, DOI: 10.1016/j.psyneuen.2016.09.006.
- Wisco BE, Marx BP, Miller MW, Wolf EJ, Mota NP, Krystal JH, Southwick SM, Pietrzak RH. Probable Posttraumatic Stress Disorder in the US Veteran Population According to DSM-5: Results From the National Health and Resilience in Veterans Study. The Journal Of Clinical Psychiatry 2016, 77: 1503-1510. PMID: 27631148, DOI: 10.4088/jcp.15m10188.
- Heinz A, Voss M, Lawrie SM, Mishara A, Bauer M, Gallinat J, Juckel G, Lang U, Rapp M, Falkai P, Strik W, Krystal J, Abi-Dargham A, Galderisi S. Shall we really say goodbye to first rank symptoms? European Psychiatry 2016, 37: 8-13. PMID: 27429167, DOI: 10.1016/j.eurpsy.2016.04.010.
- Hodgson K, Almasy L, Knowles EE, Kent JW, Curran JE, Dyer TD, Göring HH, Olvera RL, Fox PT, Pearlson GD, Krystal JH, Duggirala R, Blangero J, Glahn DC. Genome-wide significant loci for addiction and anxiety. European Psychiatry 2016, 36: 47-54. PMID: 27318301, PMCID: PMC5483998, DOI: 10.1016/j.eurpsy.2016.03.004.
- Krystal JH, Bugno R. Biological Psychiatry: We’re Just Getting Started! Biological Psychiatry 2016, 80: 500-501. PMID: 27601337, DOI: 10.1016/j.biopsych.2016.06.024.
- Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AF, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA, Carter CS, Cook EH, Daskalakis ZJ, DiLeone RJ, Duman RS, Grace AA, Hariri AR, Harrison PJ, Hiroi N, Kenny PJ, Kleinman JE, Krystal AD, Lewis DA, Lipska BK, Marder SR, Mason GF, Mathalon DH, McClung CA, McDougle CJ, McIntosh AM, McMahon FJ, Mirnics K, Monteggia LM, Narendran R, Nestler EJ, Neumeister A, O’Donovan M, Öngür D, Pariante CM, Paulus MP, Pearlson G, Phillips ML, Pine DS, Pizzagalli DA, Pletnikov MV, Ragland JD, Rapoport JL, Ressler KJ, Russo SJ, Sanacora G, Sawa A, Schatzberg AF, Shaham Y, Shamay-Tsoory SG, Sklar P, State MW, Stein MB, Strakowski SM, Taylor SF, Turecki G, Turetsky BI, Weissman MM, Zachariou V, Zarate CA, Zubieta JK. Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research. Biological Psychiatry 2016, 80: 84-86. PMID: 27346079, PMCID: PMC6150945, DOI: 10.1016/j.biopsych.2016.05.004.
- Kort NS, Ford JM, Roach BJ, Gunduz-Bruce H, Krystal JH, Jaeger J, Reinhart RM, Mathalon DH. Role of N-Methyl-D-Aspartate Receptors in Action-Based Predictive Coding Deficits in Schizophrenia. Biological Psychiatry 2016, 81: 514-524. PMID: 27647218, PMCID: PMC5203970, DOI: 10.1016/j.biopsych.2016.06.019.
- Krystal JH, Abi-Dargham A, Barch DM, Bullmore ET, Carter CS, Geschwind DH, Harrison PJ, Nestler EJ, Stein MB. Biological Psychiatry and Biological Psychiatry: Cognitive Neuroscience and Neuroimaging Adopt Neuroscience-Based Nomenclature. Biological Psychiatry 2016, 80: 2-3. PMID: 27312230, DOI: 10.1016/j.biopsych.2016.03.2103.
- Scott JC, Woods SP, Wrocklage KM, Schweinsburg BC, Southwick SM, Krystal JH. Prospective Memory in Posttraumatic Stress Disorder. Journal Of The International Neuropsychological Society 2016, 22: 724-734. PMID: 27353125, DOI: 10.1017/s1355617716000564.
- Sippel LM, Mota NP, Kachadourian LK, Krystal JH, Southwick SM, Harpaz-Rotem I, Pietrzak RH. The burden of hostility in U.S. Veterans: Results from the National Health and Resilience in Veterans Study. Psychiatry Research 2016, 243: 421-430. PMID: 27450745, DOI: 10.1016/j.psychres.2016.06.040.
- Krystal JH, Abi-Dargham A, Barch DM, Bullmore ET, Carter CS, Geschwind DH, Harrison PJ, Nestler EJ, Stein MB. Biological Psychiatry and Biological Psychiatry: Cognitive Neuroscience and Neuroimaging Adopt Neuroscience-Based Nomenclature. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2016, 1: 300-301. PMID: 29560862, DOI: 10.1016/j.bpsc.2016.03.007.
- Gerin MI, Fichtenholtz H, Roy A, Walsh CJ, Krystal JH, Southwick S, Hampson M. Real-Time fMRI Neurofeedback with War Veterans with Chronic PTSD: A Feasibility Study. Frontiers In Psychiatry 2016, 7: 111. PMID: 27445868, PMCID: PMC4914513, DOI: 10.3389/fpsyt.2016.00111.
- Otto MW, Pollack MH, Dowd SM, Hofmann SG, Pearlson G, Szuhany KL, Gueorguieva R, Krystal JH, Simon NM, Tolin DF. RANDOMIZED TRIAL OF D‐CYCLOSERINE ENHANCEMENT OF COGNITIVE‐BEHAVIORAL THERAPY FOR PANIC DISORDER. Depression And Anxiety 2016, 33: 737-745. PMID: 27315514, PMCID: PMC5958622, DOI: 10.1002/da.22531.
- Mota NP, Tsai J, Sareen J, Marx BP, Wisco BE, Harpaz-Rotem I, Southwick SM, Krystal JH, Pietrzak RH. High burden of subthreshold DSM‐5 post‐traumatic stress disorder in U.S. military veterans. World Psychiatry 2016, 15: 185-186. PMID: 27265715, PMCID: PMC4911785, DOI: 10.1002/wps.20313.
- Krystal J, Sanacora G, Abdallah C, Duman R. Speaker 4: John Krystal, USA. The International Journal Of Neuropsychopharmacology 2016, 19: 19-19. PMCID: PMC5616528, DOI: 10.1093/ijnp/pyw042.052.
- Fuehrlein BS, Mota N, Arias AJ, Trevisan LA, Kachadourian LK, Krystal JH, Southwick SM, Pietrzak RH. The burden of alcohol use disorders in US military veterans: results from the National Health and Resilience in Veterans Study. Addiction 2016, 111: 1786-1794. PMID: 27061707, DOI: 10.1111/add.13423.
- Murrough JW, Abdallah CG, Anticevic A, Collins KA, Geha P, Averill LA, Schwartz J, DeWilde KE, Averill C, Jia-Wei Yang G, Wong E, Tang CY, Krystal JH, Iosifescu DV, Charney DS. Reduced global functional connectivity of the medial prefrontal cortex in major depressive disorder. Human Brain Mapping 2016, 37: 3214-3223. PMID: 27144347, PMCID: PMC4980239, DOI: 10.1002/hbm.23235.
- Abdallah CG, Adams TG, Kelmendi B, Esterlis I, Sanacora G, Krystal JH. KETAMINE'S MECHANISM OF ACTION: A PATH TO RAPID‐ACTING ANTIDEPRESSANTS. Depression And Anxiety 2016, 33: 689-697. PMID: 27062302, PMCID: PMC4961540, DOI: 10.1002/da.22501.
- Watkins LE, Han S, Harpaz-Rotem I, Mota NP, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. FKBP5 polymorphisms, childhood abuse, and PTSD symptoms: Results from the National Health and Resilience in Veterans Study. Psychoneuroendocrinology 2016, 69: 98-105. PMID: 27078785, DOI: 10.1016/j.psyneuen.2016.04.001.
- Mota N, Tsai J, Kirwin PD, Harpaz-Rotem I, Krystal JH, Southwick SM, Pietrzak RH. Late-life exacerbation of PTSD symptoms in US veterans: results from the National Health and Resilience in Veterans Study. The Journal Of Clinical Psychiatry 2016, 77: 348-54. PMID: 27046308, DOI: 10.4088/jcp.15m10101.
- Duman RS, Aghajanian GK, Sanacora G, Krystal JH. Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nature Medicine 2016, 22: 238-249. PMID: 26937618, PMCID: PMC5405628, DOI: 10.1038/nm.4050.
- Wrocklage KM, Schweinsburg BC, Krystal JH, Trejo M, Roy A, Weisser V, Moore TM, Southwick SM, Scott JC. Neuropsychological Functioning in Veterans with Posttraumatic Stress Disorder: Associations with Performance Validity, Comorbidities, and Functional Outcomes. Journal Of The International Neuropsychological Society 2016, 22: 399-411. PMID: 26892753, DOI: 10.1017/s1355617716000059.
- Krystal JH. Neuroethology as a translational neuroscience strategy in the era of the NIMH Research Domain Criteria. Psychophysiology 2016, 53: 364-366. PMID: 26877127, PMCID: PMC4758465, DOI: 10.1111/psyp.12465.
- Rich AM, Cho YT, Tang Y, Savic A, Krystal JH, Wang F, Xu K, Anticevic A. Amygdala volume is reduced in early course schizophrenia. Psychiatry Research Neuroimaging 2016, 250: 50-60. PMID: 27035063, PMCID: PMC4904038, DOI: 10.1016/j.pscychresns.2016.02.006.
- Hu S, Zhang S, Chao HH, Krystal JH, Li CS. Association of Drinking Problems and Duration of Alcohol Use to Inhibitory Control in Nondependent Young Adult Social Drinkers. Alcohol Clinical And Experimental Research 2016, 40: 319-328. PMID: 26833431, PMCID: PMC4742397, DOI: 10.1111/acer.12964.
- Krystal JH, Pietrzak RH, Rosenheck RA, Cramer JA, Vessicchio J, Jones KM, Huang GD, Vertrees JE, Collins J, Krystal AD. Sleep disturbance in chronic military-related PTSD: clinical impact and response to adjunctive risperidone in the Veterans Affairs cooperative study #504. The Journal Of Clinical Psychiatry 2016, 77: 483-91. PMID: 26890894, DOI: 10.4088/jcp.14m09585.
- Southwick SM, Sippel L, Krystal J, Charney D, Mayes L, Pietrzak R. Why are some individuals more resilient than others: the role of social support. World Psychiatry 2016, 15: 77-79. PMID: 26833614, PMCID: PMC4780285, DOI: 10.1002/wps.20282.
- Chekroud AM, Zotti RJ, Shehzad Z, Gueorguieva R, Johnson MK, Trivedi MH, Cannon TD, Krystal JH, Corlett PR. Cross-trial prediction of treatment outcome in depression: a machine learning approach. The Lancet Psychiatry 2016, 3: 243-250. PMID: 26803397, DOI: 10.1016/s2215-0366(15)00471-x.
- Cavus I, Widi GA, Duckrow RB, Zaveri H, Kennard JT, Krystal J, Spencer DD. 50 Hz hippocampal stimulation in refractory epilepsy: Higher level of basal glutamate predicts greater release of glutamate. Epilepsia 2016, 57: 288-297. PMID: 26749134, DOI: 10.1111/epi.13269.
- Guille C, Zhao Z, Krystal J, Nichols B, Brady K, Sen S. Web-Based Cognitive Behavioral Therapy Intervention for the Prevention of Suicidal Ideation in Medical Interns: A Randomized Clinical Trial. Missouri Medicine 2016, 113: 19. PMID: 30228438, PMCID: PMC6139738.
- Abdallah CG, Averill LA, Krystal JH, Southwick SM, Arnsten AF. Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology. Behavioral And Brain Sciences 2016, 39: e201. PMID: 28347382, PMCID: PMC5485236, DOI: 10.1017/s0140525x15001727.
- Yang GJ, Murray JD, Wang XJ, Glahn DC, Pearlson GD, Repovs G, Krystal JH, Anticevic A. Functional hierarchy underlies preferential connectivity disturbances in schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 113: e219-e228. PMID: 26699491, PMCID: PMC4720350, DOI: 10.1073/pnas.1508436113.
- Krystal JH, Anticevic A. Toward Illness Phase–Specific Pharmacotherapy for Schizophrenia. Biological Psychiatry 2015, 78: 738-740. PMID: 26542740, DOI: 10.1016/j.biopsych.2015.08.017.
- Corbin WR, Papova A, Morean ME, O’Malley S, Krishnan-Sarin S, Abi-Dargham A, Anticevic A, Pearlson G, Petrakis I, Pittman BP, Krystal JH. Integrating Acquired Preparedness and Dual Process Models of Risk for Heavy Drinking and Related Problems. Psychology Of Addictive Behaviors 2015, 29: 864-874. PMID: 26348221, PMCID: PMC6223629, DOI: 10.1037/adb0000093.
- Guille C, Zhao Z, Krystal J, Nichols B, Brady K, Sen S. Web-Based Cognitive Behavioral Therapy Intervention for the Prevention of Suicidal Ideation in Medical Interns: A Randomized Clinical Trial. JAMA Psychiatry 2015, 72: 1-7. PMID: 26535958, PMCID: PMC4866804, DOI: 10.1001/jamapsychiatry.2015.1880.
- Licznerski P, Duric V, Banasr M, Alavian KN, Ota KT, Kang HJ, Jonas EA, Ursano R, Krystal JH, Duman RS, . Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic Stress. PLOS Biology 2015, 13: e1002282. PMID: 26506154, PMCID: PMC4623974, DOI: 10.1371/journal.pbio.1002282.
- Yoon G, Pittman B, Limoncelli D, Krystal JH, Petrakis IL. Familial Alcoholism Risk and the Ratio of Stimulant to Sedative Effects of Ketamine. Biological Psychiatry 2015, 79: e69-e70. PMID: 26475672, DOI: 10.1016/j.biopsych.2015.09.006.
- Southwick SM, Pietrzak RH, Charney DS, Krystal JH. Resilience: The role of accurate appraisal, thresholds, and socioenvironmental factors 1. Behavioral And Brain Sciences 2015, 38: e122. PMID: 26786005, DOI: 10.1017/s0140525x14001708.
- Zuo L, Tan Y, Zhang X, Wang X, Krystal J, Tabakoff B, Zhong C, Luo X. A New Genomewide Association Meta‐Analysis of Alcohol Dependence. Alcohol Clinical And Experimental Research 2015, 39: 1388-1395. PMID: 26173551, PMCID: PMC5587504, DOI: 10.1111/acer.12786.
- Stone J, Kotoula V, Dietrich C, De Simoni S, Krystal JH, Mehta MA. Perceptual distortions and delusional thinking following ketamine administration are related to increased pharmacological MRI signal changes in the parietal lobe. Journal Of Psychopharmacology 2015, 29: 1025-1028. PMID: 26152321, DOI: 10.1177/0269881115592337.
- Krystal JH, Stossel S, Krystal AD. Restricting Benzodiazepines to Short-Term Prescription. JAMA Psychiatry 2015, 72: 734-735. PMID: 25923129, DOI: 10.1001/jamapsychiatry.2015.0351.
- Zuo L, Saba L, Lin X, Tan Y, Wang K, Krystal JH, Tabakoff B, Luo X. Significant association between rare IPO11‐HTR1A variants and attention deficit hyperactivity disorder in Caucasians. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2015, 168: 544-556. PMID: 26079129, PMCID: PMC4851708, DOI: 10.1002/ajmg.b.32329.
- Chekroud AM, Krystal JH. Personalised pharmacotherapy: an interim solution for antidepressant treatment? The BMJ 2015, 350: h2502. PMID: 25976040, DOI: 10.1136/bmj.h2502.
- Ahn KH, Sewell A, Elander J, Pittman B, Ranganathan M, Gunduz-Bruce H, Krystal J, D'Souza DC. Role of GABA Deficit in Sensitivity to the Psychotomimetic Effects of Amphetamine. Neuropsychopharmacology 2015, 40: 2822-2831. PMID: 25953357, PMCID: PMC4864658, DOI: 10.1038/npp.2015.132.
- Lingjun Z, ZHANG CK, SAYWARD FG, CHEUNG KH, Kesheng W, KRYSTAL JH, Hongyu Z, Xingguang L. Gene-based and pathway-based genome-wide association study of alcohol dependence. General Psychiatry 2015, 27: 111-118. PMID: 26120261, PMCID: PMC4466852, DOI: 10.11919/j.issn.1002-0829.215031.
- Krystal JH, Carter CS. Introducing a New Journal: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. Biological Psychiatry 2015, 77: 922. PMID: 25959562, DOI: 10.1016/j.biopsych.2015.04.009.
- Abdallah C, Krystal J. Ketamine. 2015, 857-862. DOI: 10.1007/978-3-642-36172-2_7031.
- Pietrzak RH, Averill LA, Abdallah CG, Neumeister A, Krystal JH, Levy I, Harpaz-Rotem I. Amygdala-Hippocampal Volume and the Phenotypic Heterogeneity of Posttraumatic Stress Disorder: A Cross-Sectional Study. JAMA Psychiatry 2015, 72: 396-398. PMID: 25692480, PMCID: PMC5134909, DOI: 10.1001/jamapsychiatry.2014.2470.
- Krystal JH. Deconstructing N-Methyl-D-Aspartate Glutamate Receptor Contributions to Cortical Circuit Functions to Construct Better Hypotheses About the Pathophysiology of Schizophrenia. Biological Psychiatry 2015, 77: 508-510. PMID: 25687430, DOI: 10.1016/j.biopsych.2014.10.010.
- Abdallah CG, Averill LA, Krystal JH. Ketamine as a promising prototype for a new generation of rapid‐acting antidepressants. Annals Of The New York Academy Of Sciences 2015, 1344: 66-77. PMID: 25727103, PMCID: PMC4412785, DOI: 10.1111/nyas.12718.
- Krishnan‐Sarin S, O'Malley SS, Franco N, Cavallo DA, Morean M, Shi J, Pittman B, Krystal JH. N‐Methyl‐d‐Aspartate Receptor Antagonism has Differential Effects on Alcohol Craving and Drinking in Heavy Drinkers. Alcohol Clinical And Experimental Research 2015, 39: 300-307. PMID: 25664775, PMCID: PMC4331214, DOI: 10.1111/acer.12619.
- Krystal JH, O'Malley SS. From Translational Neuroscience to Personalized Medicine. Alcohol Clinical And Experimental Research 2015, 39: 585-586. PMID: 25656652, DOI: 10.1111/acer.12667.
- Anticevic A, Hu X, Xiao Y, Hu J, Li F, Bi F, Cole MW, Savic A, Yang GJ, Repovs G, Murray JD, Wang XJ, Huang X, Lui S, Krystal JH, Gong Q. Early-Course Unmedicated Schizophrenia Patients Exhibit Elevated Prefrontal Connectivity Associated with Longitudinal Change. Journal Of Neuroscience 2015, 35: 267-286. PMID: 25568120, PMCID: PMC4287147, DOI: 10.1523/jneurosci.2310-14.2015.
- Krystal JH. Biological Psychiatry: Looking Good! Biological Psychiatry 2015, 77: 2. PMID: 25483341, DOI: 10.1016/j.biopsych.2014.10.007.
- Scott JC, Matt GE, Wrocklage KM, Crnich C, Jordan J, Southwick SM, Krystal JH, Schweinsburg BC. A Quantitative Meta-Analysis of Neurocognitive Functioning in Posttraumatic Stress Disorder. Psychological Bulletin 2015, 141: 105-140. PMID: 25365762, PMCID: PMC4293317, DOI: 10.1037/a0038039.
- Xu K, Krystal JH, Ning Y, Chen da C, He H, Wang D, Ke X, Zhang X, Ding Y, Liu Y, Gueorguieva R, Wang Z, Limoncelli D, Pietrzak RH, Petrakis IL, Zhang X, Fan N. Preliminary analysis of positive and negative syndrome scale in ketamine-associated psychosis in comparison with schizophrenia. Journal Of Psychiatric Research 2014, 61: 64-72. PMID: 25560772, PMCID: PMC4445679, DOI: 10.1016/j.jpsychires.2014.12.012.
- Cosgrove KP, McKay R, Esterlis I, Kloczynski T, Perkins E, Bois F, Pittman B, Lancaster J, Glahn DC, O’Malley S, Carson RE, Krystal JH. Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 18031-18036. PMID: 25453062, PMCID: PMC4273348, DOI: 10.1073/pnas.1413947111.
- Saricicek A, Chen J, Planeta B, Ruf B, Subramanyam K, Maloney K, Matuskey D, Labaree D, Deserno L, Neumeister A, Krystal JH, Gallezot JD, Huang Y, Carson RE, Bhagwagar Z. Test–retest reliability of the novel 5-HT1B receptor PET radioligand [11C]P943. European Journal Of Nuclear Medicine And Molecular Imaging 2014, 42: 468-477. PMID: 25427881, DOI: 10.1007/s00259-014-2958-5.
- Tsai J, Harpaz-Rotem I, Armour C, Southwick SM, Krystal JH, Pietrzak RH. Dimensional structure of DSM-5 posttraumatic stress disorder symptoms: results from the National Health and Resilience in Veterans Study. The Journal Of Clinical Psychiatry 2014, 76: 546-53. PMID: 25562376, DOI: 10.4088/jcp.14m09091.
- Wang XJ, Krystal JH. Computational Psychiatry. Neuron 2014, 84: 638-654. PMID: 25442941, PMCID: PMC4255477, DOI: 10.1016/j.neuron.2014.10.018.
- Abdallah CG, Jiang L, De Feyter HM, Fasula M, Krystal JH, Rothman DL, Mason GF, Sanacora G. Glutamate Metabolism in Major Depressive Disorder. American Journal Of Psychiatry 2014, 171: 1320-1327. PMID: 25073688, PMCID: PMC4472484, DOI: 10.1176/appi.ajp.2014.14010067.
- Pietrzak RH, Rosenheck RA, Cramer JA, Vessichio JC, Tsai J, Southwick SM, Krystal JH, Group F. Elucidating the transdiagnostic dimensional structure of trauma-related psychopathology: Findings from VA cooperative study 504 – risperidone treatment for military service related chronic post traumatic stress disorder. Journal Of Affective Disorders 2014, 172: 331-336. PMID: 25451434, DOI: 10.1016/j.jad.2014.10.025.
- Abdallah CG, Sanacora G, Duman RS, Krystal JH. Ketamine and Rapid-Acting Antidepressants: A Window into a New Neurobiology for Mood Disorder Therapeutics. Annual Review Of Medicine 2014, 66: 1-15. PMID: 25341010, PMCID: PMC4428310, DOI: 10.1146/annurev-med-053013-062946.
- Morean ME, DeMartini KS, Leeman RF, Pearlson GD, Anticevic A, Krishnan-Sarin S, Krystal JH, O’Malley S. Psychometrically Improved, Abbreviated Versions of Three Classic Measures of Impulsivity and Self-Control. Psychological Assessment 2014, 26: 1003-1020. PMID: 24885848, PMCID: PMC4152397, DOI: 10.1037/pas0000003.
- Anticevic A, Corlett PR, Cole MW, Savic A, Gancsos M, Tang Y, Repovs G, Murray JD, Driesen NR, Morgan PT, Xu K, Wang F, Krystal JH. N-Methyl-D-Aspartate Receptor Antagonist Effects on Prefrontal Cortical Connectivity Better Model Early Than Chronic Schizophrenia. Biological Psychiatry 2014, 77: 569-580. PMID: 25281999, DOI: 10.1016/j.biopsych.2014.07.022.
- Gallezot J, Esterlis I, Bois F, Zheng M, Lin S, Kloczynski T, Krystal JH, Huang Y, Sabri O, Carson RE, Cosgrove KP. Evaluation of the sensitivity of the novel α4β2* nicotinic acetylcholine receptor PET radioligand 18F‐(‐)‐NCFHEB to increases in synaptic acetylcholine levels in rhesus monkeys. Synapse 2014, 68: 556-564. PMID: 25043426, PMCID: PMC4224280, DOI: 10.1002/syn.21767.
- In Vivo Ketamine-Induced Changes in [11C]ABP688 Binding to Metabotropic Glutamate Receptor Subtype 5DeLorenzo C, DellaGioia N, Bloch M, Sanacora G, Nabulsi N, Abdallah C, Yang J, Wen R, Mann JJ, Krystal JH, Parsey RV, Carson RE, Esterlis I. In Vivo Ketamine-Induced Changes in [11C]ABP688 Binding to Metabotropic Glutamate Receptor Subtype 5. Biological Psychiatry 2014, 77: 266-275. PMID: 25156701, PMCID: PMC4277907, DOI: 10.1016/j.biopsych.2014.06.024.
- Baldan L, Williams K, Gallezot J, Pogorelov V, Rapanelli M, Crowley M, Anderson G, Loring E, Gorczyca R, Billingslea E, Wasylink S, Panza K, Ercan-Sencicek A, Krusong K, Leventhal B, Ohtsu H, Bloch M, Hughes Z, Krystal J, Mayes L, de Araujo I, Ding Y, State M, Pittenger C. Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice. Neuron 2014, 82: 1186-1187. DOI: 10.1016/j.neuron.2014.05.023.
- Abdallah C, Krystal J. Ketamine. 2014, 1-6. DOI: 10.1007/978-3-642-27772-6_7031-1.
- Yang GJ, Murray JD, Repovs G, Cole MW, Savic A, Glasser MF, Pittenger C, Krystal JH, Wang XJ, Pearlson GD, Glahn DC, Anticevic A. Altered global brain signal in schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 7438-7443. PMID: 24799682, PMCID: PMC4034208, DOI: 10.1073/pnas.1405289111.
- Anticevic A, Savic A, Repovs G, Yang G, McKay DR, Sprooten E, Knowles EE, Krystal JH, Pearlson GD, Glahn DC. Ventral Anterior Cingulate Connectivity Distinguished Nonpsychotic Bipolar Illness From Psychotic Bipolar Disorder and Schizophrenia. Schizophrenia Bulletin 2014, 41: 133-143. PMID: 24782562, PMCID: PMC4266289, DOI: 10.1093/schbul/sbu051.
- Anticevic A, Murray J, Repovs G, Starc M, Santamauro N, Savic A, Morgan P, Wang X, Krystal J. 5:45 PM INTEGRATING PHARMACOLOGY AND COMPUTATION: TOWARDS UNDERSTANDING MECHANISMS OF COGNITIVE AND CONNECTIVITY DEFICITS IN SCHIZOPHRENIA. Schizophrenia Research 2014, 153: s52-s53. DOI: 10.1016/s0920-9964(14)70172-0.
- Rosenheck R, Leatherman S, Krystal J, Liang M. Poster #T200 SUBGROUP ANALYSIS IN A RANDOMIZED CLINICAL TRIAL OF LONG-ACTING INJECTABLE RISPERIDONE AND ORAL ANTIPSYCHOTICS IN UNSTABLE CHRONIC SCHIZOPHRENIA. Schizophrenia Research 2014, 153: s360. DOI: 10.1016/s0920-9964(14)71016-3.
- Krystal JH, State MW. Psychiatric Disorders: Diagnosis to Therapy. Cell 2014, 157: 201-214. PMID: 24679536, PMCID: PMC4104191, DOI: 10.1016/j.cell.2014.02.042.
- Stefanovics EA, Krystal JH, Rosenheck RA. Symptom structure and severity: A comparison of responses to the positive and negative syndrome scale (PANSS) between patients with PTSD or schizophrenia. Comprehensive Psychiatry 2014, 55: 887-895. PMID: 24602497, DOI: 10.1016/j.comppsych.2014.01.014.
- Baldan LC, Williams KA, Gallezot JD, Pogorelov V, Rapanelli M, Crowley M, Anderson GM, Loring E, Gorczyca R, Billingslea E, Wasylink S, Panza KE, Ercan-Sencicek AG, Krusong K, Leventhal BL, Ohtsu H, Bloch MH, Hughes ZA, Krystal JH, Mayes L, de Araujo I, Ding YS, State MW, Pittenger C. Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice. Neuron 2014, 81: 77-90. PMID: 24411733, PMCID: PMC3894588, DOI: 10.1016/j.neuron.2013.10.052.
- Boggs DL, Carlson J, Cortes-Briones J, Krystal JH, D'Souza DC. Going up in smoke? A review of nAChRs-based treatment strategies for improving cognition in schizophrenia. Current Pharmaceutical Design 2014, 20: 5077-92. PMID: 24345265, PMCID: PMC4442779, DOI: 10.2174/1381612819666131216121019.
- Leatherman SM, Liang MH, Krystal JH, Lew RA, Valley D, Thwin SS, Rosenheck RA. Differences in Treatment Effect Among Clinical Subgroups in a Randomized Clinical Trial of Long-Acting Injectable Risperidone and Oral Antipsychotics in Unstable Chronic Schizophrenia. The Journal Of Nervous And Mental Disease 2014, 202: 13-17. PMID: 24375206, DOI: 10.1097/nmd.0000000000000069.
- Anticevic A, Tang Y, Cho YT, Repovs G, Cole MW, Savic A, Wang F, Krystal JH, Xu K. Amygdala Connectivity Differs Among Chronic, Early Course, and Individuals at Risk for Developing Schizophrenia. Schizophrenia Bulletin 2013, 40: 1105-1116. PMID: 24366718, PMCID: PMC4133672, DOI: 10.1093/schbul/sbt165.
- Zuo L, Wang K, Zhang X, Pan X, Wang G, Krystal JH, Zhang H, Luo X. Sex chromosome-wide association analysis suggested male-specific risk genes for alcohol dependence. Psychiatric Genetics 2013, 23: 233-238. PMID: 23907288, PMCID: PMC3941913, DOI: 10.1097/ypg.0b013e328364b8c7.
- Anticevic A, Hu S, Zhang S, Savic A, Billingslea E, Wasylink S, Repovs G, Cole MW, Bednarski S, Krystal JH, Bloch MH, Li CS, Pittenger C. Global Resting-State Functional Magnetic Resonance Imaging Analysis Identifies Frontal Cortex, Striatal, and Cerebellar Dysconnectivity in Obsessive-Compulsive Disorder. Biological Psychiatry 2013, 75: 595-605. PMID: 24314349, PMCID: PMC3969771, DOI: 10.1016/j.biopsych.2013.10.021.
- Pietrzak RH, Gallezot JD, Ding YS, Henry S, Potenza MN, Southwick SM, Krystal JH, Carson RE, Neumeister A. Association of Posttraumatic Stress Disorder With Reduced In Vivo Norepinephrine Transporter Availability in the Locus Coeruleus. JAMA Psychiatry 2013, 70: 1199-1205. PMID: 24048210, PMCID: PMC4026855, DOI: 10.1001/jamapsychiatry.2013.399.
- Krystal J. Pl.2 - KETAMINE. Behavioural Pharmacology 2013, 24: e1. DOI: 10.1097/01.fbp.0000434680.00108.7d.
- Krystal J. S.19.04 Glutamatergic contributions to reward dysfunction in alcohol dependence. European Neuropsychopharmacology 2013, 23: s141. DOI: 10.1016/s0924-977x(13)70198-6.
- Krystal JH. Biological Psychiatry: Raising the Bar. Biological Psychiatry 2013, 74: 476-477. PMID: 24034363, DOI: 10.1016/j.biopsych.2013.07.034.
- Holmes A, Spanagel R, Krystal JH. Glutamatergic targets for new alcohol medications. Psychopharmacology 2013, 229: 539-554. PMID: 23995381, PMCID: PMC3811052, DOI: 10.1007/s00213-013-3226-2.
- Zuo L, Wang KS, Zhang XY, Li CS, Zhang F, Wang X, Chen W, Gao G, Zhang H, Krystal JH, Luo X. Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent. Pharmacogenetics And Genomics 2013, 23: 395-402. PMID: 23778322, PMCID: PMC4287355, DOI: 10.1097/fpc.0b013e328362f9f2.
- Xie P, Kranzler HR, Krystal JH, Farrer LA, Zhao H, Gelernter J. Deep resequencing of 17 glutamate system genes identifies rare variants in DISC1 and GRIN2B affecting risk of opioid dependence. Addiction Biology 2013, 19: 955-964. PMID: 23855403, PMCID: PMC3815683, DOI: 10.1111/adb.12072.
- Driesen NR, McCarthy G, Bhagwagar Z, Bloch MH, Calhoun VD, D'Souza DC, Gueorguieva R, He G, Leung HC, Ramani R, Anticevic A, Suckow RF, Morgan PT, Krystal JH. The Impact of NMDA Receptor Blockade on Human Working Memory-Related Prefrontal Function and Connectivity. Neuropsychopharmacology 2013, 38: 2613-2622. PMID: 23856634, PMCID: PMC3828532, DOI: 10.1038/npp.2013.170.
- Anticevic A, Cole MW, Repovs G, Murray JD, Brumbaugh MS, Winkler AM, Savic A, Krystal JH, Pearlson GD, Glahn DC. Characterizing Thalamo-Cortical Disturbances in Schizophrenia and Bipolar Illness. Cerebral Cortex 2013, 24: 3116-3130. PMID: 23825317, PMCID: PMC4224238, DOI: 10.1093/cercor/bht165.
- Zuo L, Saba L, Wang K, Zhang X, Krystal JH, Tabakoff B, Luo X. Exome-wide association study of replicable nonsynonymous variants conferring risk for alcohol dependence. Journal Of Studies On Alcohol And Drugs 2013, 74: 622-5. PMID: 23739027, PMCID: PMC3711352, DOI: 10.15288/jsad.2013.74.622.
- Corlett PR, Cambridge V, Gardner JM, Piggot JS, Turner DC, Everitt JC, Arana FS, Morgan HL, Milton AL, Lee JL, Aitken MR, Dickinson A, Everitt BJ, Absalom AR, Adapa R, Subramanian N, Taylor JR, Krystal JH, Fletcher PC. Ketamine Effects on Memory Reconsolidation Favor a Learning Model of Delusions. PLOS ONE 2013, 8: e65088. PMID: 23776445, PMCID: PMC3680467, DOI: 10.1371/journal.pone.0065088.
- Krystal JH, Sanacora G, Duman RS. Rapid-Acting Glutamatergic Antidepressants: The Path to Ketamine and Beyond. Biological Psychiatry 2013, 73: 1133-1141. PMID: 23726151, PMCID: PMC3671489, DOI: 10.1016/j.biopsych.2013.03.026.
- DeVito EE, Meda SA, Jiantonio R, Potenza MN, Krystal JH, Pearlson GD. Neural Correlates of Impulsivity in Healthy Males and Females with Family Histories of Alcoholism. Neuropsychopharmacology 2013, 38: 1854-1863. PMID: 23584260, PMCID: PMC3746701, DOI: 10.1038/npp.2013.92.
- Jiang L, Gulanski BI, De Feyter HM, Weinzimer SA, Pittman B, Guidone E, Koretski J, Harman S, Petrakis IL, Krystal JH, Mason GF. Increased brain uptake and oxidation of acetate in heavy drinkers. Journal Of Clinical Investigation 2013, 123: 1605-1614. PMID: 23478412, PMCID: PMC3613911, DOI: 10.1172/jci65153.
- Zuo L, Wang K, Zhang XY, Pan X, Wang G, Tan Y, Zhong C, Krystal JH, State M, Zhang H, Luo X. Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism. Human Genetics 2013, 132: 735-743. PMID: 23468174, PMCID: PMC3683370, DOI: 10.1007/s00439-013-1277-4.
- Narayanan B, Stevens MC, Jiantonio RE, Krystal JH, Pearlson GD. Effects of memantine on event-related potential, oscillations, and complexity in individuals with and without family histories of alcoholism. Journal Of Studies On Alcohol And Drugs 2013, 74: 245-57. PMID: 23384372, PMCID: PMC3568163, DOI: 10.15288/jsad.2013.74.245.
- Zuo L, Wang K, Zhang XY, Krystal JH, Li CS, Zhang F, Zhang H, Luo X. NKAIN1–SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent. Drug And Alcohol Dependence 2013, 129: 254-264. PMID: 23455491, PMCID: PMC3628730, DOI: 10.1016/j.drugalcdep.2013.02.006.
- Gueorguieva R, Wu R, Krystal JH, Donovan D, O'Malley SS. Temporal patterns of adherence to medications and behavioral treatment and their relationship to patient characteristics and treatment response. Addictive Behaviors 2013, 38: 2119-2127. PMID: 23435273, PMCID: PMC3595348, DOI: 10.1016/j.addbeh.2013.01.024.
- Anticevic A, Krystal J, Barch D. Translational cognitive neuroscience of schizophrenia: bridging neurocognitive and computational approaches toward understanding cognitive deficits. 2013, 193-230. DOI: 10.1017/cbo9781139003872.013.
- Driesen NR, McCarthy G, Bhagwagar Z, Bloch M, Calhoun V, D'Souza DC, Gueorguieva R, He G, Ramachandran R, Suckow RF, Anticevic A, Morgan PT, Krystal JH. Relationship of resting brain hyperconnectivity and schizophrenia-like symptoms produced by the NMDA receptor antagonist ketamine in humans. Molecular Psychiatry 2013, 18: 1199-1204. PMID: 23337947, PMCID: PMC3646075, DOI: 10.1038/mp.2012.194.
- Anticevic A, Cole MW, Repovs G, Savic A, Driesen NR, Yang G, Cho YT, Murray JD, Glahn DC, Wang XJ, Krystal JH. Connectivity, Pharmacology, and Computation: Toward a Mechanistic Understanding of Neural System Dysfunction in Schizophrenia. Frontiers In Psychiatry 2013, 4: 169. PMID: 24399974, PMCID: PMC3871997, DOI: 10.3389/fpsyt.2013.00169.
- Insel T, Krystal J, Ehlers M. New drug development for cognitive enhancement in mental health: Challenges and opportunities. Neuropharmacology 2013, 64: 2-7. PMID: 23145450, DOI: 10.1016/j.neuropharm.2012.07.041.
- Zuo L, Zhang X, Wang F, Li C, Lu L, Ye L, Zhang H, Krystal JH, Deng H, Luo X. Genome‐Wide Significant Association Signals in IPO11‐HTR1A Region Specific for Alcohol and Nicotine Codependence. Alcohol Clinical And Experimental Research 2012, 37: 730-739. PMID: 23216389, PMCID: PMC3610804, DOI: 10.1111/acer.12032.
- Murray JD, Anticevic A, Gancsos M, Ichinose M, Corlett PR, Krystal JH, Wang XJ. Linking Microcircuit Dysfunction to Cognitive Impairment: Effects of Disinhibition Associated with Schizophrenia in a Cortical Working Memory Model. Cerebral Cortex 2012, 24: 859-872. PMID: 23203979, PMCID: PMC3948492, DOI: 10.1093/cercor/bhs370.
- Anticevic A, Cole MW, Murray JD, Corlett PR, Wang XJ, Krystal JH. The role of default network deactivation in cognition and disease. Trends In Cognitive Sciences 2012, 16: 584-592. PMID: 23142417, PMCID: PMC3501603, DOI: 10.1016/j.tics.2012.10.008.
- Fryer SL, Jorgensen KW, Yetter EJ, Daurignac EC, Watson TD, Shanbhag H, Krystal JH, Mathalon DH. Differential brain response to alcohol cue distractors across stages of alcohol dependence. Biological Psychology 2012, 92: 282-291. PMID: 23131612, PMCID: PMC3947923, DOI: 10.1016/j.biopsycho.2012.10.004.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: Report of two pilot studies. European Neuropsychopharmacology 2012, 23: 931-940. PMID: 23089076, PMCID: PMC4028140, DOI: 10.1016/j.euroneuro.2012.09.008.
- Zuo L, Zhang H, Malison RT, Li CS, Zhang XY, Wang F, Lu L, Lu L, Wang X, Krystal JH, Zhang F, Deng HW, Luo X. Rare ADH Variant Constellations are Specific for Alcohol Dependence. Alcohol And Alcoholism 2012, 48: 9-14. PMID: 23019235, PMCID: PMC3523382, DOI: 10.1093/alcalc/ags104.
- Anticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ, Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH, Corlett PR. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16720-16725. PMID: 23012427, PMCID: PMC3478611, DOI: 10.1073/pnas.1208494109.
- Anticevic A, Brumbaugh MS, Winkler AM, Lombardo LE, Barrett J, Corlett PR, Kober H, Gruber J, Repovs G, Cole MW, Krystal JH, Pearlson GD, Glahn DC. Global Prefrontal and Fronto-Amygdala Dysconnectivity in Bipolar I Disorder with Psychosis History. Biological Psychiatry 2012, 73: 565-573. PMID: 22980587, PMCID: PMC3549314, DOI: 10.1016/j.biopsych.2012.07.031.
- Moghaddam B, Krystal JH. Capturing the Angel in “Angel Dust”: Twenty Years of Translational Neuroscience Studies of NMDA Receptor Antagonists in Animals and Humans. Schizophrenia Bulletin 2012, 38: 942-949. PMID: 22899397, PMCID: PMC3446228, DOI: 10.1093/schbul/sbs075.
- Anticevic A, Repovs G, Krystal JH, Barch DM. A broken filter: Prefrontal functional connectivity abnormalities in schizophrenia during working memory interference. Schizophrenia Research 2012, 141: 8-14. PMID: 22863548, PMCID: PMC3879404, DOI: 10.1016/j.schres.2012.07.007.
- Bloch MH, Wasylink S, Landeros-Weisenberger A, Panza KE, Billingslea E, Leckman JF, Krystal JH, Bhagwagar Z, Sanacora G, Pittenger C. Effects of Ketamine in Treatment-Refractory Obsessive-Compulsive Disorder. Biological Psychiatry 2012, 72: 964-970. PMID: 22784486, PMCID: PMC3667652, DOI: 10.1016/j.biopsych.2012.05.028.
- Nestler EJ, Krystal JH. Planning the New National Institute on Substance Use and Addiction Disorders. Biological Psychiatry 2012, 72: 166-167. PMID: 22683089, DOI: 10.1016/j.biopsych.2012.05.011.
- Krystal JH. Enhancing Prolonged Exposure Therapy for Posttraumatic Stress Disorder with D-Cycloserine: Further Support for Treatments That Promote Experience-Dependent Neuroplasticity. Biological Psychiatry 2012, 71: 932-934. PMID: 22579302, DOI: 10.1016/j.biopsych.2012.03.031.
- Pietrzak RH, Henry S, Southwick SM, Krystal JH, Neumeister A. Linking in vivo brain serotonin type 1B receptor density to phenotypic heterogeneity of posttraumatic stress symptomatology. Molecular Psychiatry 2012, 18: 399-401. PMID: 22584868, DOI: 10.1038/mp.2012.60.
- Barnett PG, Scott JY, Krystal JH, Rosenheck RA. Cost and cost-effectiveness in a randomized trial of long-acting risperidone for schizophrenia. The Journal Of Clinical Psychiatry 2012, 73: 696-702. PMID: 22697193, DOI: 10.4088/jcp.11m07070.
- Hyatt CJ, Assaf M, Muska CE, Rosen RI, Thomas AD, Johnson MR, Hylton JL, Andrews MM, Reynolds BA, Krystal JH, Potenza MN, Pearlson GD. Reward-Related Dorsal Striatal Activity Differences between Former and Current Cocaine Dependent Individuals during an Interactive Competitive Game. PLOS ONE 2012, 7: e34917. PMID: 22606228, PMCID: PMC3351439, DOI: 10.1371/journal.pone.0034917.
- Zuo L, Zhang F, Zhang H, Zhang X, Wang F, Li C, Lu L, Hong J, Lu L, Krystal J, Deng H, Luo X. Genome‐wide search for replicable risk gene regions in alcohol and nicotine co‐dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2012, 159B: 437-444. PMID: 22488850, PMCID: PMC3405545, DOI: 10.1002/ajmg.b.32047.
- Stone J, Dietrich C, Edden R, Mehta M, De Simoni S, Reed L, Krystal J, Nutt D, Barker G. P.3.001 Ketamine-induced changes in anterior cingulate glutamate levels correlate with positive symptom generation. European Neuropsychopharmacology 2012, 22: s52-s53. DOI: 10.1016/s0924-977x(12)70054-8.
- Pietrzak RH, Maruff P, Woodward M, Fredrickson J, Fredrickson A, Krystal JH, Southwick SM, Darby D. Mild Worry Symptoms Predict Decline in Learning and Memory in Healthy Older Adults: A 2-Year Prospective Cohort Study. American Journal Of Geriatric Psychiatry 2012, 20: 266-275. PMID: 22354117, PMCID: PMC3285262, DOI: 10.1097/jgp.0b013e3182107e24.
- Çavuş I, Reinhart RM, Roach BJ, Gueorguieva R, Teyler TJ, Clapp WC, Ford JM, Krystal JH, Mathalon DH. Impaired Visual Cortical Plasticity in Schizophrenia. Biological Psychiatry 2012, 71: 512-520. PMID: 22364738, PMCID: PMC3292767, DOI: 10.1016/j.biopsych.2012.01.013.
- Jamadar S, DeVito EE, Jiantonio RE, Meda SA, Stevens MC, Potenza MN, Krystal JH, Pearlson GD. Memantine, an NMDA receptor antagonist, differentially influences Go/No-Go performance and fMRI activity in individuals with and without a family history of alcoholism. Psychopharmacology 2012, 222: 129-140. PMID: 22311382, PMCID: PMC3674025, DOI: 10.1007/s00213-011-2628-2.
- Stone JM, Dietrich C, Edden R, Mehta MA, De Simoni S, Reed LJ, Krystal JH, Nutt D, Barker GJ. Ketamine effects on brain GABA and glutamate levels with 1H-MRS: relationship to ketamine-induced psychopathology. Molecular Psychiatry 2012, 17: 664-665. PMID: 22212598, PMCID: PMC3883303, DOI: 10.1038/mp.2011.171.
- Steine IM, Krystal JH, Nordhus IH, Bjorvatn B, Harvey AG, Eid J, Grønli J, Milde AM, Pallesen S. Insomnia, Nightmare Frequency, and Nightmare Distress in Victims of Sexual Abuse. Journal Of Interpersonal Violence 2011, 27: 1827-1843. PMID: 22204947, DOI: 10.1177/0886260511430385.
- Zuo L, Gelernter J, Zhang C, Zhao H, Lu L, Kranzler H, Malison R, Li C, Wang F, Zhang X, Deng H, Krystal J, Zhang F, Luo X. Erratum: Genome-Wide Association Study of Alcohol Dependence Implicates KIAA0040 on Chromosome 1q. Neuropsychopharmacology 2011, 37: 581-582. PMCID: PMC3242324, DOI: 10.1038/npp.2011.271.
- Kaffman A, Krystal J. New Frontiers in Animal Research of Psychiatric Illness. Methods In Molecular Biology 2011, 829: 3-30. PMID: 22231804, PMCID: PMC3337084, DOI: 10.1007/978-1-61779-458-2_1.
- Kaffman A, Krystal J. Erratum: New Frontiers in Animal Research of Psychiatric Illness. Methods In Molecular Biology 2011, 829: e1-e1. DOI: 10.1007/978-1-61779-458-2_38.
- Gueorguieva R, Mallinckrodt C, Krystal JH. Trajectories of Depression Severity in Clinical Trials of Duloxetine: Insights Into Antidepressant and Placebo Responses. JAMA Psychiatry 2011, 68: 1227-1237. PMID: 22147842, PMCID: PMC3339151, DOI: 10.1001/archgenpsychiatry.2011.132.
- Murrough JW, Huang Y, Hu J, Henry S, Williams W, Gallezot JD, Bailey CR, Krystal JH, Carson RE, Neumeister A. Reduced Amygdala Serotonin Transporter Binding in Posttraumatic Stress Disorder. Biological Psychiatry 2011, 70: 1033-1038. PMID: 21855859, PMCID: PMC3207037, DOI: 10.1016/j.biopsych.2011.07.003.
- Petrakis IL, Ralevski E, Desai N, Trevisan L, Gueorguieva R, Rounsaville B, Krystal JH. Noradrenergic vs Serotonergic Antidepressant with or without Naltrexone for Veterans with PTSD and Comorbid Alcohol Dependence. Neuropsychopharmacology 2011, 37: 996-1004. PMID: 22089316, PMCID: PMC3280636, DOI: 10.1038/npp.2011.283.
- Zuo L, Zhang CK, Wang F, Li CS, Zhao H, Lu L, Zhang XY, Lu L, Zhang H, Zhang F, Krystal JH, Luo X. A Novel, Functional and Replicable Risk Gene Region for Alcohol Dependence Identified by Genome-Wide Association Study. PLOS ONE 2011, 6: e26726. PMID: 22096494, PMCID: PMC3210123, DOI: 10.1371/journal.pone.0026726.
- Urban NB, Slifstein M, Meda S, Xu X, Ayoub R, Medina O, Pearlson GD, Krystal JH, Abi-Dargham A. Imaging human reward processing with positron emission tomography and functional magnetic resonance imaging. Psychopharmacology 2011, 221: 67-77. PMID: 22052081, DOI: 10.1007/s00213-011-2543-6.
- Gunduz-Bruce H, Reinhart RM, Roach BJ, Gueorguieva R, Oliver S, D'Souza DC, Ford JM, Krystal JH, Mathalon DH. Glutamatergic Modulation of Auditory Information Processing in the Human Brain. Biological Psychiatry 2011, 71: 969-977. PMID: 22036036, PMCID: PMC3290754, DOI: 10.1016/j.biopsych.2011.09.031.
- Marder SR, Roth B, Sullivan PF, Scolnick EM, Nestler EJ, Geyer MA, Welnberger DR, Karayiorgou M, Guidotti A, Gingrich J, Akbarian S, Buchanan RW, Lieberman JA, Conn PJ, Haggarty SJ, Law AJ, Campbell B, Krystal JH, Moghaddam B, Saw A, Caron MG, George SR, Allen JA, Solis M. Advancing drug discovery for schizophrenia. Annals Of The New York Academy Of Sciences 2011, 1236: 30-43. PMID: 22032400, PMCID: PMC3787879, DOI: 10.1111/j.1749-6632.2011.06216.x.
- Zuo L, Gelernter J, Zhang CK, Zhao H, Lu L, Kranzler HR, Malison RT, Li CS, Wang F, Zhang XY, Deng HW, Krystal JH, Zhang F, Luo X. Genome-Wide Association Study of Alcohol Dependence Implicates KIAA0040 on Chromosome 1q. Neuropsychopharmacology 2011, 37: 557-566. PMID: 21956439, DOI: 10.1038/npp.2011.229.
- Gueorguieva R, Wu R, Donovan D, Rounsaville BJ, Couper D, Krystal JH, O’Malley S. Baseline trajectories of heavy drinking and their effects on postrandomization drinking in the COMBINE Study: empirically derived predictors of drinking outcomes during treatment. Alcohol 2011, 46: 121-131. PMID: 21925828, PMCID: PMC3266454, DOI: 10.1016/j.alcohol.2011.08.008.
- Murrough JW, Czermak C, Henry S, Nabulsi N, Gallezot JD, Gueorguieva R, Planeta-Wilson B, Krystal JH, Neumaier JF, Huang Y, Ding YS, Carson RE, Neumeister A. The Effect of Early Trauma Exposure on Serotonin Type 1B Receptor Expression Revealed by Reduced Selective Radioligand Binding. JAMA Psychiatry 2011, 68: 892-900. PMID: 21893657, PMCID: PMC3244836, DOI: 10.1001/archgenpsychiatry.2011.91.
- Gomez R, Behar KL, Watzl J, Weinzimer SA, Gulanski B, Sanacora G, Koretski J, Guidone E, Jiang L, Petrakis IL, Pittman B, Krystal JH, Mason GF. Intravenous Ethanol Infusion Decreases Human Cortical γ-Aminobutyric Acid and N-Acetylaspartate as Measured with Proton Magnetic Resonance Spectroscopy at 4 Tesla. Biological Psychiatry 2011, 71: 239-246. PMID: 21855054, PMCID: PMC3227760, DOI: 10.1016/j.biopsych.2011.06.026.
- Krystal JH, Rosenheck RA, Cramer JA, Vessicchio JC, Jones KM, Vertrees JE, Horney RA, Huang GD, Stock C, Group F. Adjunctive Risperidone Treatment for Antidepressant-Resistant Symptoms of Chronic Military Service–Related PTSD: A Randomized Trial. JAMA 2011, 306: 493-502. PMID: 21813427, DOI: 10.1001/jama.2011.1080.
- Freeman WM, VanGuilder HD, Guidone E, Krystal JH, Grant KA, Vrana KE. Plasma proteomic alterations in non-human primates and humans after chronic alcohol self-administration. The International Journal Of Neuropsychopharmacology 2011, 14: 899-911. PMID: 21303580, PMCID: PMC3107900, DOI: 10.1017/s1461145711000046.
- Krystal J. Biological Psychiatry: A Time of Opportunity, a Time of Challenge. Biological Psychiatry 2011, 70: 3-4. DOI: 10.1016/j.biopsych.2011.04.020.
- Xie P, Kranzler HR, Krauthammer M, Cosgrove KP, Oslin D, Anton RF, Farrer LA, Picciotto MR, Krystal JH, Zhao H, Gelernter J. Rare Nonsynonymous Variants in Alpha-4 Nicotinic Acetylcholine Receptor Gene Protect Against Nicotine Dependence. Biological Psychiatry 2011, 70: 528-536. PMID: 21683344, PMCID: PMC3199609, DOI: 10.1016/j.biopsych.2011.04.017.
- Steine IM, Harvey AG, Krystal JH, Milde AM, Grønli J, Bjorvatn B, Nordhus IH, Eid J, Pallesen S. Sleep disturbances in sexual abuse victims: A systematic review. Sleep Medicine Reviews 2011, 16: 15-25. PMID: 21600813, DOI: 10.1016/j.smrv.2011.01.006.
- Carter CS, Barch DM, Bullmore E, Breiling J, Buchanan RW, Butler P, Cohen JD, Geyer M, Gollub R, Green MF, Jaeger J, Krystal JH, Moore H, Nuechterlein K, Robbins T, Silverstein S, Smith EE, Strauss M, Wykes T. Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia II: Developing Imaging Biomarkers to Enhance Treatment Development for Schizophrenia and Related Disorders. Biological Psychiatry 2011, 70: 7-12. PMID: 21529781, PMCID: PMC3116022, DOI: 10.1016/j.biopsych.2011.01.041.
- Soyka M, Kranzler HR, van den Brink W, Krystal J, Möller HJ, Kasper S, Treatment G. The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Substance Use and Related Disorders. Part 2: Opioid dependence. The World Journal Of Biological Psychiatry 2011, 12: 160-187. PMID: 21486104, DOI: 10.3109/15622975.2011.561872.
- Rosenheck RA, Krystal JH, Lew R, Barnett PG, Fiore L, Valley D, Thwin SS, Vertrees JE, Liang MH. Long-Acting Risperidone and Oral Antipsychotics in Unstable Schizophrenia. New England Journal Of Medicine 2011, 364: 842-851. PMID: 21366475, DOI: 10.1056/nejmoa1005987.
- Krystal J, Petrakis I, Limoncelli D, Nappi S, Trevisan L, Pittman B, D'Souza D. Erratum: Characterization of the Interactive Effects of Glycine and D-Cycloserine in Men: Further Evidence for Enhanced NMDA Receptor Function Associated with Human Alcohol Dependence. Neuropsychopharmacology 2011, 36: 911-911. PMCID: PMC3055722, DOI: 10.1038/npp.2011.2.
- Cosgrove KP, Esterlis I, Mason GF, Bois F, O’Malley S, Krystal JH. Neuroimaging insights into the role of cortical GABA systems and the influence of nicotine on the recovery from alcohol dependence. Neuropharmacology 2011, 60: 1318-1325. PMID: 21276806, PMCID: PMC3078950, DOI: 10.1016/j.neuropharm.2011.01.020.
- Rosenheck RA, Krystal JH, Lew R, Barnett PG, Thwin SS, Fiore L, Valley D, Huang GD, Neal C, Vertrees JE, Liang MH. Challenges in the design and conduct of controlled clinical effectiveness trials in schizophrenia. Clinical Trials 2011, 8: 196-204. PMID: 21270143, DOI: 10.1177/1740774510392931.
- Valentine GW, Mason GF, Gomez R, Fasula M, Watzl J, Pittman B, Krystal JH, Sanacora G. The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [1H]-MRS. Psychiatry Research 2011, 191: 122-127. PMID: 21232924, PMCID: PMC3061550, DOI: 10.1016/j.pscychresns.2010.10.009.
- Krystal J, Moghaddam B. Contributions of Glutamate and GABA Systems to the Neurobiology and Treatment of Schizophrenia. 2010, 433-461. DOI: 10.1002/9781444327298.ch21.
- Gueorguieva R, Wu R, Donovan D, Rounsaville BJ, Couper D, Krystal JH, O’Malley S. Baseline Trajectories of Drinking Moderate Acamprosate and Naltrexone Effects in the COMBINE Study. Alcohol Clinical And Experimental Research 2010, 35: 523-531. PMID: 21143249, PMCID: PMC3062945, DOI: 10.1111/j.1530-0277.2010.01369.x.
- Andrews MM, Meda SA, Thomas AD, Potenza MN, Krystal JH, Worhunsky P, Stevens MC, O'Malley S, Book GA, Reynolds B, Pearlson GD. Individuals Family History Positive for Alcoholism Show Functional Magnetic Resonance Imaging Differences in Reward Sensitivity That Are Related to Impulsivity Factors. Biological Psychiatry 2010, 69: 675-683. PMID: 21126735, PMCID: PMC3677031, DOI: 10.1016/j.biopsych.2010.09.049.
- Krystal JH, Petrakis IL, Limoncelli D, Nappi SK, Trevisan L, Pittman B, D'Souza DC. Characterization of the Interactive Effects of Glycine and D-Cycloserine in Men: Further Evidence for Enhanced NMDA Receptor Function Associated with Human Alcohol Dependence. Neuropsychopharmacology 2010, 36: 701-710. PMID: 21124304, PMCID: PMC3055693, DOI: 10.1038/npp.2010.203.
- Hallak JE, Dursun SM, Bosi DC, de Macedo LR, Machado-de-Sousa JP, Abrão J, Crippa JA, McGuire P, Krystal JH, Baker GB, Zuardi AW. The interplay of cannabinoid and NMDA glutamate receptor systems in humans: Preliminary evidence of interactive effects of cannabidiol and ketamine in healthy human subjects. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2010, 35: 198-202. PMID: 21062637, DOI: 10.1016/j.pnpbp.2010.11.002.
- N- methyl-D-aspartate Glutamate Receptor Antagonists and the Promise of Rapid-Acting AntidepressantsKrystal JH. N- methyl-D-aspartate Glutamate Receptor Antagonists and the Promise of Rapid-Acting Antidepressants. JAMA Psychiatry 2010, 67: 1110-1111. PMID: 21041611, DOI: 10.1001/archgenpsychiatry.2010.138.
- Corlett PR, Honey GD, Krystal JH, Fletcher PC. Glutamatergic Model Psychoses: Prediction Error, Learning, and Inference. Neuropsychopharmacology 2010, 36: 294-315. PMID: 20861831, PMCID: PMC3055519, DOI: 10.1038/npp.2010.163.
- Sewell RA, Perry EB, Karper LP, Bell MD, Lysaker P, Goulet JL, Brenner L, Erdos J, d'Souza DC, Seibyl JP, Krystal JH. Clinical significance of neurological soft signs in schizophrenia: Factor analysis of the Neurological Evaluation Scale. Schizophrenia Research 2010, 124: 1-12. PMID: 20855185, DOI: 10.1016/j.schres.2010.08.036.
- Nakic M, Krystal J, Bhagwagar Z. Neurotransmitter Systems in Bipolar Disorder. 2010, 210-227. DOI: 10.1002/9780470661277.ch16.
- Urban NB, Kegeles LS, Slifstein M, Xu X, Martinez D, Sakr E, Castillo F, Moadel T, O'Malley SS, Krystal JH, Abi-Dargham A. Sex Differences in Striatal Dopamine Release in Young Adults After Oral Alcohol Challenge: A Positron Emission Tomography Imaging Study With [11C]Raclopride. Biological Psychiatry 2010, 68: 689-696. PMID: 20678752, PMCID: PMC2949533, DOI: 10.1016/j.biopsych.2010.06.005.
- Krystal JH, Mathew SJ, D’Souza D, Garakani A, Gunduz-Bruce H, Charney DS. Potential Psychiatric Applications of Metabotropic Glutamate Receptor Agonists and Antagonists. CNS Drugs 2010, 24: 669-693. PMID: 20658799, DOI: 10.2165/11533230-000000000-00000.
- Corlett PR, Taylor JR, Wang X, Fletcher PC, Krystal JH. Toward a neurobiology of delusions. Progress In Neurobiology 2010, 92: 345-369. PMID: 20558235, PMCID: PMC3676875, DOI: 10.1016/j.pneurobio.2010.06.007.
- Sen S, Kranzler H, Krystal J, Speller H, Chan G, Gelernter J, Guille C. In Reply. JAMA Psychiatry 2010, 67: 568-569. DOI: 10.1001/archgenpsychiatry.2010.53.
- Cosgrove KP, Kloczynski T, Bois F, Pittman B, Tamagnan G, Seibyl JP, Krystal JH, Staley JK. Decreased Beta2*‐nicotinic acetylcholine receptor availability after chronic ethanol exposure in nonhuman primates. Synapse 2010, 64: 729-732. PMID: 20340174, PMCID: PMC2904861, DOI: 10.1002/syn.20795.
- Corlett PR, D'Souza DC, Krystal JH. Capgras Syndrome Induced by Ketamine in a Healthy Subject. Biological Psychiatry 2010, 68: e1-e2. PMID: 20385373, PMCID: PMC3721067, DOI: 10.1016/j.biopsych.2010.02.015.
- Sen S, Kranzler HR, Krystal JH, Speller H, Chan G, Gelernter J, Guille C. A Prospective Cohort Study Investigating Factors Associated With Depression During Medical Internship. JAMA Psychiatry 2010, 67: 557-565. PMID: 20368500, PMCID: PMC4036806, DOI: 10.1001/archgenpsychiatry.2010.41.
- Cavus I, Guglielmino R, Ford J, Roach B, Krystal J, Gueorguieva R, Mathalon D. IMPAIRED LONG-TERM POTENTIATION OF THE VISUAL EVOKED POTENTIAL IN SCHIZOPHRENIA. Schizophrenia Research 2010, 117: 244-245. DOI: 10.1016/j.schres.2010.02.373.
- Aikins DE, Anticevic A, Kiehl KA, Krystal JH. Sex-related differences in amygdala activity influences immediate memory. Neuroreport 2010, 21: 273-276. PMID: 20093991, DOI: 10.1097/wnr.0b013e328335b3f9.
- Hu J, Henry S, Gallezot JD, Ropchan J, Neumaier JF, Potenza MN, Sinha R, Krystal JH, Huang Y, Ding YS, Carson RE, Neumeister A. Serotonin 1B Receptor Imaging in Alcohol Dependence. Biological Psychiatry 2010, 67: 800-803. PMID: 20172504, PMCID: PMC3112181, DOI: 10.1016/j.biopsych.2009.12.028.
- Yun RJ, Krystal JH, Mathalon DH. Working Memory Overload: Fronto-Limbic Interactions and Effects on Subsequent Working Memory Function. Brain Imaging And Behavior 2010, 4: 96-108. PMID: 20503117, PMCID: PMC2854358, DOI: 10.1007/s11682-010-9089-9.
- Esterlis I, Cosgrove KP, Petrakis IL, McKee SA, Bois F, Krantzler E, Stiklus SM, Perry EB, Tamagnan GD, Seibyl JP, Krystal JH, Staley JK. SPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individuals. Drug And Alcohol Dependence 2010, 108: 146-150. PMID: 20074869, PMCID: PMC2871672, DOI: 10.1016/j.drugalcdep.2009.12.006.
- Gueorguieva R, Wu R, Donovan D, Rounsaville BJ, Couper D, Krystal JH, O’Malley S. Naltrexone and combined behavioral intervention effects on trajectories of drinking in the COMBINE study. Drug And Alcohol Dependence 2009, 107: 221-229. PMID: 19969427, PMCID: PMC2821955, DOI: 10.1016/j.drugalcdep.2009.10.017.
- Zuo L, Luo X, Kranzler HR, Lu L, Rosenheck RA, Cramer J, van Kammen DP, Erdos J, Charney DS, Krystal J, Gelernter J. Association study of DTNBP1 with schizophrenia in a US sample. Psychiatric Genetics 2009, 19: 292-304. PMID: 19862852, PMCID: PMC2771321, DOI: 10.1097/ypg.0b013e32832a50bc.
- Corlett PR, Simons JS, Pigott JS, Gardner JM, Murray GK, Krystal JH, Fletcher PC. Illusions and Delusions: Relating Experimentally-Induced False Memories to Anomalous Experiences and Ideas. Frontiers In Behavioral Neuroscience 2009, 3: 53. PMID: 19956402, PMCID: PMC2786301, DOI: 10.3389/neuro.08.053.2009.
- Krystal JH. The evolution of the psychiatry research journal. The Journal Of Clinical Psychiatry 2009, 70: 1601-2. PMID: 20031103, DOI: 10.4088/jcp.09com05629whi.
- Otto MW, Tolin DF, Simon NM, Pearlson GD, Basden S, Meunier SA, Hofmann SG, Eisenmenger K, Krystal JH, Pollack MH. Efficacy of D-Cycloserine for Enhancing Response to Cognitive-Behavior Therapy for Panic Disorder. Biological Psychiatry 2009, 67: 365-370. PMID: 19811776, DOI: 10.1016/j.biopsych.2009.07.036.
- Corlett PR, Krystal JH, Taylor JR, Fletcher PC. Why Do Delusions Persist? Frontiers In Human Neuroscience 2009, 3: 12. PMID: 19636384, PMCID: PMC2713737, DOI: 10.3389/neuro.09.012.2009.
- Landeros-Weisenberger A, Bloch MH, Kelmendi B, Wegner R, Nudel J, Dombrowski P, Pittenger C, Krystal JH, Goodman WK, Leckman JF, Coric V. Dimensional predictors of response to SRI pharmacotherapy in obsessive–compulsive disorder. Journal Of Affective Disorders 2009, 121: 175-179. PMID: 19577308, PMCID: PMC3974618, DOI: 10.1016/j.jad.2009.06.010.
- Driesen N, McCarthy G, Bhagwagar Z, Calhoun V, D'Souza D, Holub J, Morgan P, Krystal J. NMDA Receptor Antagonist Ketamine Produces Opposing Effects on Resting and Task-Related Brain Activation During Working Memory in Humans. NeuroImage 2009, 47: s145. DOI: 10.1016/s1053-8119(09)71458-2.
- Zuo L, Luo X, Krystal JH, Cramer J, Charney DS, Gelernter J. The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation. Pharmacogenetics And Genomics 2009, 19: 437-446. PMID: 19369910, PMCID: PMC2857717, DOI: 10.1097/fpc.0b013e32832b9cfc.
- Krystal JH, Tolin DF, Sanacora G, Castner SA, Williams GV, Aikins DE, Hoffman RE, D'Souza DC. Neuroplasticity as a target for the pharmacotherapy of anxiety disorders, mood disorders, and schizophrenia. Drug Discovery Today 2009, 14: 690-697. PMID: 19460458, PMCID: PMC2898127, DOI: 10.1016/j.drudis.2009.05.002.
- Cosgrove KP, Krantzler E, Frohlich EB, Stiklus S, Pittman B, Tamagnan GD, Baldwin RM, Bois F, Seibyl JP, Krystal JH, O'Malley SS, Staley JK. Dopamine and Serotonin Transporter Availability During Acute Alcohol Withdrawal: Effects of Comorbid Tobacco Smoking. Neuropsychopharmacology 2009, 34: 2218-2226. PMID: 19440191, PMCID: PMC4457331, DOI: 10.1038/npp.2009.49.
- Krystal JH, Neumeister A. Noradrenergic and serotonergic mechanisms in the neurobiology of posttraumatic stress disorder and resilience. Brain Research 2009, 1293: 13-23. PMID: 19332037, PMCID: PMC2761677, DOI: 10.1016/j.brainres.2009.03.044.
- Zuo L, Luo X, Listman JB, Kranzler HR, Wang S, Anton RF, Blumberg HP, Stein MB, Pearlson GD, Covault J, Charney DS, van Kammen DP, Price LH, Lappalainen J, Cramer J, Krystal JH, Gelernter J. Population admixture modulates risk for alcohol dependence. Human Genetics 2009, 125: 605-613. PMID: 19306106, PMCID: PMC2777998, DOI: 10.1007/s00439-009-0647-4.
- Krystal J. Biological Psychiatry: Real Progress. Biological Psychiatry 2009, 65: 3-4. DOI: 10.1016/j.biopsych.2008.08.026.
- Ranganathan M, Braley G, Pittman B, Cooper T, Perry E, Krystal J, D’Souza D. The effects of cannabinoids on serum cortisol and prolactin in humans. Psychopharmacology 2008, 203: 737. PMID: 19083209, PMCID: PMC2863108, DOI: 10.1007/s00213-008-1422-2.
- Southwick S, Friedman M, Krystal J. Does Psychoeducation Help Prevent Post Traumatic Psychological Stress Disorder? In Reply. Psychiatry 2008, 71: 303-307. PMID: 19152277, DOI: 10.1521/psyc.2008.71.4.303.
- Dickerson D, Pittman B, Ralevski E, Perrino A, Limoncelli D, Edgecombe J, Acampora G, Krystal J, Petrakis I. Ethanol-like effects of thiopental and ketamine in healthy humans. Journal Of Psychopharmacology 2008, 24: 203-211. PMID: 19028835, PMCID: PMC4484757, DOI: 10.1177/0269881108098612.
- Barch DM, Carter CS, Arnsten A, Buchanan RW, Cohen JD, Geyer M, Green MF, Krystal JH, Nuechterlein K, Robbins T, Silverstein S, Smith EE, Strauss M, Wykes T, Heinssen R. Selecting Paradigms From Cognitive Neuroscience for Translation into Use in Clinical Trials: Proceedings of the Third CNTRICS Meeting. Schizophrenia Bulletin 2008, 35: 109-114. PMID: 19023126, PMCID: PMC2643950, DOI: 10.1093/schbul/sbn163.
- Weder N, Yang BZ, Douglas-Palumberi H, Massey J, Krystal JH, Gelernter J, Kaufman J. MAOA Genotype, Maltreatment, and Aggressive Behavior: The Changing Impact of Genotype at Varying Levels of Trauma. Biological Psychiatry 2008, 65: 417-424. PMID: 18996506, PMCID: PMC3816252, DOI: 10.1016/j.biopsych.2008.09.013.
- Martinez D, Slifstein M, Gil R, Hwang DR, Huang Y, Perez A, Frankle WG, Laruelle M, Krystal J, Abi-Dargham A. Positron Emission Tomography Imaging of the Serotonin Transporter and 5-HT1A Receptor in Alcohol Dependence. Biological Psychiatry 2008, 65: 175-180. PMID: 18962444, PMCID: PMC2621104, DOI: 10.1016/j.biopsych.2008.08.034.
- Perepletchikova F, Krystal JH, Kaufman J. Practitioner Review: Adolescent alcohol use disorders: assessment and treatment issues. Journal Of Child Psychology And Psychiatry 2008, 49: 1131-1154. PMID: 19017028, PMCID: PMC4113213, DOI: 10.1111/j.1469-7610.2008.01934.x.
- Driesen NR, Leung HC, Calhoun VD, Constable RT, Gueorguieva R, Hoffman R, Skudlarski P, Goldman-Rakic PS, Krystal JH. Impairment of Working Memory Maintenance and Response in Schizophrenia: Functional Magnetic Resonance Imaging Evidence. Biological Psychiatry 2008, 64: 1026-1034. PMID: 18823880, PMCID: PMC2650279, DOI: 10.1016/j.biopsych.2008.07.029.
- Watson TD, Petrakis IL, Edgecombe J, Perrino A, Krystal JH, Mathalon DH. Modulation of the cortical processing of novel and target stimuli by drugs affecting glutamate and GABA neurotransmission. The International Journal Of Neuropsychopharmacology 2008, 12: 357-370. PMID: 18771605, PMCID: PMC2900256, DOI: 10.1017/s1461145708009334.
- Pittenger C, Coric V, Banasr M, Bloch M, Krystal JH, Sanacora G. Riluzole in the Treatment of Mood and Anxiety Disorders. CNS Drugs 2008, 22: 761-786. PMID: 18698875, DOI: 10.2165/00023210-200822090-00004.
- Krystal JH. Capitalizing on Extrasynaptic Glutamate Neurotransmission to Treat Antipsychotic-Resistant Symptoms in Schizophrenia. Biological Psychiatry 2008, 64: 358-360. PMID: 18694665, DOI: 10.1016/j.biopsych.2008.06.011.
- Cavus I, Pan JW, Hetherington HP, Abi‐Saab W, Zaveri HP, Vives KP, Krystal JH, Spencer SS, Spencer DD. Decreased hippocampal volume on MRI is associated with increased extracellular glutamate in epilepsy patients. Epilepsia 2008, 49: 1358-1366. PMID: 18410365, DOI: 10.1111/j.1528-1167.2008.01603.x.
- Carter CS, Barch DM, Buchanan RW, Bullmore E, Krystal JH, Cohen J, Geyer M, Green M, Nuechterlein KH, Robbins T, Silverstein S, Smith EE, Strauss M, Wykes T, Heinssen R. Identifying Cognitive Mechanisms Targeted for Treatment Development in Schizophrenia: An Overview of the First Meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia Initiative. Biological Psychiatry 2008, 64: 4-10. PMID: 18466880, PMCID: PMC2577821, DOI: 10.1016/j.biopsych.2008.03.020.
- Sanacora G, Zarate CA, Krystal JH, Manji HK. Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders. Nature Reviews Drug Discovery 2008, 7: 426-437. PMID: 18425072, PMCID: PMC2715836, DOI: 10.1038/nrd2462.
- Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, Berman KF, Blair J, Braff DL, Brown ES, Calabrese JR, Carlezon WA, Cook EH, Davidson RJ, Davis M, Desimone R, Drevets WC, Duman RS, Essock SM, Faraone SV, Freedman R, Friston KJ, Gelernter J, Geller B, Gill M, Gould E, Grace AA, Grillon C, Gueorguieva R, Hariri AR, Innis RB, Jones EG, Kleinman JE, Koob GF, Krystal AD, Leibenluft E, Levinson DF, Levitt PR, Lewis DA, Liberzon I, Lipska BK, Marder SR, Markou A, Mason GF, McDougle CJ, McEwen BS, McMahon FJ, Meaney MJ, Meltzer HY, Merikangas KR, Meyer-Lindenberg A, Mirnics K, Monteggia LM, Neumeister A, O’Brien C, Owen MJ, Pine DS, Rapoport JL, Rauch SL, Robbins TW, Rosenbaum JF, Rosenberg DR, Ross CA, Rush AJ, Sackeim HA, Sanacora G, Schatzberg AF, Shaham Y, Siever LJ, Sunderland T, Tecott LH, Thase ME, Todd RD, Weissman MM, Yehuda R, Yoshikawa T, Young EA, McCandless R. It Is Time to Take a Stand for Medical Research and Against Terrorism Targeting Medical Scientists. Biological Psychiatry 2008, 63: 725-727. PMID: 18371494, DOI: 10.1016/j.biopsych.2008.03.005.
- Norberg MM, Krystal JH, Tolin DF. A Meta-Analysis of D-Cycloserine and the Facilitation of Fear Extinction and Exposure Therapy. Biological Psychiatry 2008, 63: 1118-1126. PMID: 18313643, DOI: 10.1016/j.biopsych.2008.01.012.
- Jackowski AP, Douglas-Palumberi H, Jackowski M, Win L, Schultz RT, Staib LW, Krystal JH, Kaufman J. Corpus callosum in maltreated children with posttraumatic stress disorder: A diffusion tensor imaging study. Psychiatry Research 2008, 162: 256-261. PMID: 18296031, PMCID: PMC3771642, DOI: 10.1016/j.pscychresns.2007.08.006.
- Czermak C, Staley JK, Kasserman S, Bois F, Young T, Henry S, Tamagnan GD, Seibyl JP, Krystal JH, Neumeister A. β 2 Nicotinic acetylcholine receptor availability in post-traumatic stress disorder. The International Journal Of Neuropsychopharmacology 2008, 11: 419-424. PMID: 18190729, DOI: 10.1017/s1461145707008152.
- D'Souza DC, Ranganathan M, Braley G, Gueorguieva R, Zimolo Z, Cooper T, Perry E, Krystal J. Blunted Psychotomimetic and Amnestic Effects of Δ-9-Tetrahydrocannabinol in Frequent Users of Cannabis. Neuropsychopharmacology 2008, 33: 2505-2516. PMID: 18185500, PMCID: PMC3799954, DOI: 10.1038/sj.npp.1301643.
- Stone JM, Erlandsson K, Arstad E, Squassante L, Teneggi V, Bressan RA, Krystal JH, Ell PJ, Pilowsky LS. Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy—a [123I]CNS-1261 SPET study. Psychopharmacology 2008, 197: 401-408. PMID: 18176855, DOI: 10.1007/s00213-007-1047-x.
- Esterlis I, Bois F, Cosgrove K, Stiklus S, Perry E, Tamagnan G, Seibyl J, Krystal J, Staley J. Sex differences in nicotinic acetylcholine receptor availability in heavy alcohol drinkers. NeuroImage 2008, 41: t183. DOI: 10.1016/j.neuroimage.2008.04.150.
- Urban N, Martinez D, Zhou Y, Toda M, Xu X, Kegeles L, Slifstein M, Pearlson G, Krystal J, Abi-Dargham A. New probes for imaging dopamine transmission in at risk subjects for alcoholism. NeuroImage 2008, 41: t143. DOI: 10.1016/j.neuroimage.2008.04.111.
- Neumeister A, Czermak C, Henry S, Planeta-Wilson B, Huang H, Ding Y, Krystal J, Nabulsi N, Gallezot J, Carson R. Serotonin-1B receptor imaging in PTSD. NeuroImage 2008, 41: t163. DOI: 10.1016/j.neuroimage.2008.04.130.
- Krishnan-Sarin S, O'Malley S, Krystal JH. Treatment implications: using neuroscience to guide the development of new pharmacotherapies for alcoholism. Alcohol Research 2008, 31: 400-7. PMID: 23584013, PMCID: PMC3860468.
- Heninger G, Krystal J, Duman R, Bunney B, Bowers M, Aghajanian G. The Neuroscience Research Program at the Connecticut Mental Health Center. 2007, 77-95. DOI: 10.1002/9780470994580.ch4.
- Krystal J. Biological Psychiatry: Increasing Impact. Biological Psychiatry 2007, 62: 1203-1204. DOI: 10.1016/j.biopsych.2007.09.021.
- Goff DC, Keefe R, Citrome L, Davy K, Krystal JH, Large C, Thompson TR, Volavka J, Webster EL. Lamotrigine as Add-On Therapy in Schizophrenia. Journal Of Clinical Psychopharmacology 2007, 27: 582-589. PMID: 18004124, DOI: 10.1097/jcp.0b013e31815abf34.
- Trevisan L, Petrakis IL, Pittman B, Gueorguieva R, D’Souza D, Perry E, Limoncelli D, Krystal JH. Absence of Significant Interactive Effects of High‐Dose d‐Cycloserine and Ethanol in Healthy Human Subjects: Preliminary Insights Into Ethanol Actions at the GlycineB Site of NMDA Glutamate Receptors. Alcohol Clinical And Experimental Research 2007, 32: 36-42. PMID: 18028532, DOI: 10.1111/j.1530-0277.2007.00543.x.
- Krystal JH, Gueorguieva R, Cramer J, Collins J, Rosenheck R, Team T. Naltrexone Is Associated With Reduced Drinking by Alcohol Dependent Patients Receiving Antidepressants for Mood and Anxiety Symptoms: Results From VA Cooperative Study No. 425, “Naltrexone in the Treatment of Alcoholism”. Alcohol Clinical And Experimental Research 2007, 32: 85-91. PMID: 18070245, DOI: 10.1111/j.1530-0277.2007.00555.x.
- Martinez D, Kim JH, Krystal J, Abi-Dargham A. Imaging the Neurochemistry of Alcohol and Substance Abuse. Neuroimaging Clinics Of North America 2007, 17: 539-555. PMID: 17983969, DOI: 10.1016/j.nic.2007.07.004.
- Krystal JH. Neuroplasticity as a Target for the Pharmacotherapy of Psychiatric Disorders: New Opportunities for Synergy with Psychotherapy. Biological Psychiatry 2007, 62: 833-834. PMID: 17916459, DOI: 10.1016/j.biopsych.2007.08.017.
- Epperson CN, Amin Z, Naftolin F, Cappiello A, Czarkowski KA, Stiklus S, Anderson GM, Krystal JH. The resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findings. Journal Of Psychopharmacology 2007, 21: 414-420. PMID: 16891341, DOI: 10.1177/0269881106067330.
- Kaufman J, Massey J, Krystal J, Gelernter J. Reply. Biological Psychiatry 2007, 61: 1113-1115. DOI: 10.1016/j.biopsych.2006.07.004.
- Krystal JH. Ketamine and the potential role for rapid-acting antidepressant medications. Swiss Medical Weekly 2007, 137: 215-216. PMID: 17525875, DOI: 10.4414/smw.2007.11932.
- Pittenger C, Sanacora G, Krystal JH. The NMDA receptor as a therapeutic target in major depressive disorder. CNS & Neurological Disorders - Drug Targets 2007, 6: 101-15. PMID: 17430148, DOI: 10.2174/187152707780363267.
- Ford JM, Krystal JH, Mathalon DH. Neural Synchrony in Schizophrenia: From Networks to New Treatments. Schizophrenia Bulletin 2007, 33: 848-852. PMID: 17567628, PMCID: PMC2632315, DOI: 10.1093/schbul/sbm062.
- Krishnan-Sarin S, Krystal JH, Shi J, Pittman B, O’Malley S. Family History of Alcoholism Influences Naltrexone-Induced Reduction in Alcohol Drinking. Biological Psychiatry 2007, 62: 694-697. PMID: 17336941, DOI: 10.1016/j.biopsych.2006.11.018.
- Neumeister A, Charney D, Sanacora G, Krystal J. Neurobiology and Treatment of Depression. 2007 DOI: 10.1002/9780470101001.hcn018.
- Krupitsky EM, Neznanova O, Masalov D, Burakov AM, Didenko T, Romanova T, Tsoy M, Bespalov A, Slavina TY, Grinenko AA, Petrakis IL, Pittman B, Gueorguieva R, Zvartau EE, Krystal JH. Effect of Memantine on Cue-Induced Alcohol Craving in Recovering Alcohol-Dependent Patients. American Journal Of Psychiatry 2007, 164: 519-523. PMID: 17329479, DOI: 10.1176/ajp.2007.164.3.519.
- Luteal-Phase Accentuation of Acoustic Startle Response in Women with Premenstrual Dysphoric DisorderEpperson CN, Pittman B, Czarkowski KA, Stiklus S, Krystal JH, Grillon C. Luteal-Phase Accentuation of Acoustic Startle Response in Women with Premenstrual Dysphoric Disorder. Neuropsychopharmacology 2007, 32: 2190-2198. PMID: 17314917, PMCID: PMC2713599, DOI: 10.1038/sj.npp.1301351.
- Perry EB, Cramer JA, Cho HS, Petrakis IL, Karper LP, Genovese A, O’Donnell E, Krystal JH, D’Souza D. Psychiatric safety of ketamine in psychopharmacology research. Psychopharmacology 2007, 192: 253-260. PMID: 17458544, DOI: 10.1007/s00213-007-0706-2.
- Hoffman RE, Hampson M, Wu K, Anderson AW, Gore JC, Buchanan RJ, Constable RT, Hawkins KA, Sahay N, Krystal JH. Probing the Pathophysiology of Auditory/Verbal Hallucinations by Combining Functional Magnetic Resonance Imaging and Transcranial Magnetic Stimulation. Cerebral Cortex 2007, 17: 2733-2743. PMID: 17298962, PMCID: PMC2634833, DOI: 10.1093/cercor/bhl183.
- Krupitsky EM, Rudenko AA, Burakov AM, Slavina TY, Grinenko AA, Pittman B, Gueorguieva R, Petrakis IL, Zvartau EE, Krystal JH. Antiglutamatergic Strategies for Ethanol Detoxification: Comparison With Placebo and Diazepam. Alcohol Clinical And Experimental Research 2007, 31: 604-611. PMID: 17374039, DOI: 10.1111/j.1530-0277.2007.00344.x.
- Pittman B, Gueorguieva R, Krupitsky E, Rudenko AA, Flannery BA, Krystal JH. Multidimensionality of the Alcohol Withdrawal Symptom Checklist: A Factor Analysis of the Alcohol Withdrawal Symptom Checklist and CIWA‐Ar. Alcohol Clinical And Experimental Research 2007, 31: 612-618. PMID: 17374040, DOI: 10.1111/j.1530-0277.2007.00345.x.
- Gelernter J, Gueorguieva R, Kranzler HR, Zhang H, Cramer J, Rosenheck R, Krystal JH, Group T. Opioid Receptor Gene (OPRM1, OPRK1, and OPRD1) Variants and Response to Naltrexone Treatment for Alcohol Dependence: Results From the VA Cooperative Study. Alcohol Clinical And Experimental Research 2007, 31: 555-563. PMID: 17374034, DOI: 10.1111/j.1530-0277.2007.00339.x.
- McDougle CJ, Krystal JH. Pediatric psychopharmacology: mood, anxiety and disruptive behavior/pervasive developmental disorders. Psychopharmacology 2007, 191: 1-3. PMID: 17476481, DOI: 10.1007/s00213-007-0720-4.
- Gueorguieva R, Wu R, Pittman B, Cramer J, Rosenheck RA, O’Malley S, Krystal JH. New Insights into the Efficacy of Naltrexone Based on Trajectory-Based Reanalyses of Two Negative Clinical Trials. Biological Psychiatry 2007, 61: 1290-1295. PMID: 17224132, PMCID: PMC1952242, DOI: 10.1016/j.biopsych.2006.09.038.
- Sanacora G, Kendell SF, Levin Y, Simen AA, Fenton LR, Coric V, Krystal JH. Preliminary Evidence of Riluzole Efficacy in Antidepressant-Treated Patients with Residual Depressive Symptoms. Biological Psychiatry 2006, 61: 822-825. PMID: 17141740, PMCID: PMC2754299, DOI: 10.1016/j.biopsych.2006.08.037.
- Neumeister A, Carson R, Henry S, Planeta-Wilson B, Binneman B, Maguire RP, Luckenbaugh DA, D'Souza C, Krystal JH, Frost JJ. Cerebral Metabolic Effects of Intravenous Glycine in Healthy Human Subjects. Journal Of Clinical Psychopharmacology 2006, 26: 595-599. PMID: 17110816, DOI: 10.1097/01.jcp.0000245558.14284.aa.
- Sasso DA, Kalanithi PS, Trueblood KV, Pittenger C, Kelmendi B, Wayslink S, Malison RT, Krystal JH, Coric V. Beneficial Effects of the Glutamate-modulating Agent Riluzole on Disordered Eating and Pathological Skin-picking Behaviors. Journal Of Clinical Psychopharmacology 2006, 26: 685-687. PMID: 17110840, DOI: 10.1097/01.jcp.0000245567.29531.d6.
- Kaufman J, Yang BZ, Douglas-Palumberi H, Crouse-Artus M, Lipschitz D, Krystal JH, Gelernter J. Genetic and Environmental Predictors of Early Alcohol Use. Biological Psychiatry 2006, 61: 1228-1234. PMID: 17123474, DOI: 10.1016/j.biopsych.2006.06.039.
- Lappalainen J, Krupitsky E, Kranzler HR, Luo X, Remizov M, Pchelina S, Taraskina A, Zvartau E, Räsanen P, Makikyro T, Somberg LK, Krystal JH, Stein MB, Gelernter J. Mutation screen of the GAD2 gene and association study of alcoholism in three populations. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2006, 144B: 183-192. PMID: 17034009, DOI: 10.1002/ajmg.b.30377.
- Mason GF, Krystal JH. MR spectroscopy: its potential role for drug development for the treatment of psychiatric diseases. NMR In Biomedicine 2006, 19: 690-701. PMID: 16986118, DOI: 10.1002/nbm.1080.
- Krystal JH. Biological Psychiatry: A New Leadership Team. Biological Psychiatry 2006, 60: 794-795. PMID: 17045860, DOI: 10.1016/j.biopsych.2006.09.004.
- D'Souza DC, Gil RB, Madonick S, Perry EB, Forselius-Bielen K, Braley G, Donahue L, Tellioglu T, Zimolo Z, Gueorguieva R, Krystal JH. Enhanced Sensitivity to the Euphoric Effects of Alcohol in Schizophrenia. Neuropsychopharmacology 2006, 31: 2767-2775. PMID: 16985503, DOI: 10.1038/sj.npp.1301207.
- Krystal JH, Staley J, Mason G, Petrakis IL, Kaufman J, Harris RA, Gelernter J, Lappalainen J. γ-Aminobutyric Acid Type A Receptors and Alcoholism: Intoxication, Dependence, Vulnerability, and Treatment. JAMA Psychiatry 2006, 63: 957-968. PMID: 16952998, DOI: 10.1001/archpsyc.63.9.957.
- Krystal JH, D’Souza D, Gallinat J, Driesen N, Abi-Dargham A, Petrakis I, Heinz A, Pearlson G. The vulnerability to alcohol and substance abuse in individuals diagnosed with schizophrenia. Neurotoxicity Research 2006, 10: 235-252. PMID: 17197373, DOI: 10.1007/bf03033360.
- Rasmusson AM, Pinna G, Paliwal P, Weisman D, Gottschalk C, Charney D, Krystal J, Guidotti A. Decreased Cerebrospinal Fluid Allopregnanolone Levels in Women with Posttraumatic Stress Disorder. Biological Psychiatry 2006, 60: 704-713. PMID: 16934764, DOI: 10.1016/j.biopsych.2006.03.026.
- Morgan CJ, Perry EB, Cho HS, Krystal JH, D’Souza D. Greater vulnerability to the amnestic effects of ketamine in males. Psychopharmacology 2006, 187: 405-414. PMID: 16896964, DOI: 10.1007/s00213-006-0409-0.
- Amin Z, Mason GF, Cavus I, Krystal JH, Rothman DL, Epperson CN. The interaction of neuroactive steroids and GABA in the development of neuropsychiatric disorders in women. Pharmacology Biochemistry And Behavior 2006, 84: 635-643. PMID: 16860856, DOI: 10.1016/j.pbb.2006.06.007.
- Epperson CN, Gueorguieva R, Czarkowski KA, Stiklus S, Sellers E, Krystal JH, Rothman DL, Mason GF. Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study. Psychopharmacology 2006, 186: 425. PMID: 16724188, DOI: 10.1007/s00213-006-0313-7.
- Epperson CN, deWit H, Krystal JH. Advances in the translational neuroscience of neurosteroids. Psychopharmacology 2006, 186: 265. PMID: 16555064, DOI: 10.1007/s00213-006-0310-x.
- Pittenger C, Naungayan C, Kendell S, Coric V, Malison R, Krystal JH, Sanacora GS. Visual Hallucinations from the Addition of Riluzole to Memantine and Bupropion. Journal Of Clinical Psychopharmacology 2006, 26: 218-220. PMID: 16633160, DOI: 10.1097/01.jcp.0000203228.64117.9f.
- Kaufman J, Yang BZ, Douglas-Palumberi H, Grasso D, Lipschitz D, Houshyar S, Krystal JH, Gelernter J. Brain-Derived Neurotrophic Factor–5-HTTLPR Gene Interactions and Environmental Modifiers of Depression in Children. Biological Psychiatry 2006, 59: 673-680. PMID: 16458264, DOI: 10.1016/j.biopsych.2005.10.026.
- Blumberg HP, Krystal JH, Bansal R, Martin A, Dziura J, Durkin K, Martin L, Gerard E, Charney DS, Peterson BS. Age, Rapid-Cycling, and Pharmacotherapy Effects on Ventral Prefrontal Cortex in Bipolar Disorder: A Cross-Sectional Study. Biological Psychiatry 2006, 59: 611-618. PMID: 16414030, DOI: 10.1016/j.biopsych.2005.08.031.
- D'Souza D, Krystal J. Psychoactive Drugs. 2006 DOI: 10.1002/0470018860.s00599.
- Krystal JH, Madonick S, Perry E, Gueorguieva R, Brush L, Wray Y, Belger A, D'Souza DC. Potentiation of Low Dose Ketamine Effects by Naltrexone: Potential Implications for the Pharmacotherapy of Alcoholism. Neuropsychopharmacology 2006, 31: 1793-1800. PMID: 16395307, DOI: 10.1038/sj.npp.1300994.
- Staley J, Tellioglu T, Bois F, Palazzo C, McGuire-Schwartz N, Cosgrove K, van Dyck C, Tamagnan G, Seibyl J, Krystal J, D'Souza D. [I-123] 5-IA-85380 SPECT imaging of beta2-nicotinic acetylcholine receptors in recently abstinent mentally healthy and schizophrenic smokers. NeuroImage 2006, 31: t154. DOI: 10.1016/j.neuroimage.2006.04.137.
- Pittenger C, Krystal JH, Coric V. Glutamate-modulating drugs as novel pharmacotherapeutic agents in the treatment of obsessive-compulsive disorder. Neurotherapeutics 2006, 3: 69-81. PMID: 16490414, PMCID: PMC3593363, DOI: 10.1016/j.nurx.2005.12.006.
- Lafleur DL, Pittenger C, Kelmendi B, Gardner T, Wasylink S, Malison RT, Sanacora G, Krystal JH, Coric V. N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder. Psychopharmacology 2005, 184: 254-256. PMID: 16374600, DOI: 10.1007/s00213-005-0246-6.
- Blumberg HP, Fredericks C, Wang F, Kalmar JH, Spencer L, Papademetris X, Pittman B, Martin A, Peterson BS, Fulbright RK, Krystal JH. Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder. Bipolar Disorders 2005, 7: 570-576. PMID: 16403182, PMCID: PMC2291299, DOI: 10.1111/j.1399-5618.2005.00264.x.
- Pittenger C, Krystal JH, Coric V. Initial evidence of the beneficial effects of glutamate-modulating agents in the treatment of self-injurious behavior associated with borderline personality disorder. The Journal Of Clinical Psychiatry 2005, 66: 1492-3. PMID: 16420092, DOI: 10.4088/jcp.v66n1121d.
- Keller MB, Krystal JH, Hen R, Neumeister A, Simon NM. Untangling depression and anxiety: clinical challenges. The Journal Of Clinical Psychiatry 2005, 66: 1477-84. PMID: 16420087, DOI: 10.4088/jcp.v66n1119.
- Mason GF, Petrakis IL, de Graaf RA, Gueorguieva R, Guidone E, Coric V, Epperson CN, Rothman DL, Krystal JH. Cortical Gamma-Aminobutyric Acid Levels and the Recovery from Ethanol Dependence: Preliminary Evidence of Modification by Cigarette Smoking. Biological Psychiatry 2005, 59: 85-93. PMID: 16289397, DOI: 10.1016/j.biopsych.2005.06.009.
- Pittenger C, Kelmendi B, Bloch M, Krystal JH, Coric V. Clinical treatment of obsessive compulsive disorder. Innov Clin Neurosci 2005, 2: 34-43. PMID: 21120095, PMCID: PMC2993523.
- Blumberg HP, Donegan NH, Sanislow CA, Collins S, Lacadie C, Skudlarski P, Gueorguieva R, Fulbright RK, McGlashan TH, Gore JC, Krystal JH. Preliminary evidence for medication effects on functional abnormalities in the amygdala and anterior cingulate in bipolar disorder. Psychopharmacology 2005, 183: 308-313. PMID: 16249909, DOI: 10.1007/s00213-005-0156-7.
- Pilowsky LS, Bressan RA, Stone JM, Erlandsson K, Mulligan RS, Krystal JH, Ell PJ. First in vivo evidence of an NMDA receptor deficit in medication-free schizophrenic patients. Molecular Psychiatry 2005, 11: 118-119. PMID: 16189506, DOI: 10.1038/sj.mp.4001751.
- Cho RY, Ford JM, Krystal JH, Laruelle M, Cuthbert B, Carter CS. Functional Neuroimaging and Electrophysiology Biomarkers for Clinical Trials for Cognition in Schizophrenia. Schizophrenia Bulletin 2005, 31: 865-869. PMID: 16166611, DOI: 10.1093/schbul/sbi050.
- Li CS, Krystal JH, Mathalon DH. Fore-period effect and stop-signal reaction time. Experimental Brain Research 2005, 167: 305-309. PMID: 16160823, DOI: 10.1007/s00221-005-0110-2.
- D’Souza D, Gil RB, Zuzarte E, MacDougall LM, Donahue L, Ebersole JS, Boutros NN, Cooper T, Seibyl J, Krystal JH. γ-Aminobutyric Acid–Serotonin Interactions in Healthy Men: Implications for Network Models of Psychosis and Dissociation. Biological Psychiatry 2005, 59: 128-137. PMID: 16140281, DOI: 10.1016/j.biopsych.2005.06.020.
- Sanacora G, Fenton LR, Fasula MK, Rothman DL, Levin Y, Krystal JH, Mason GF. Cortical γ-Aminobutyric Acid Concentrations in Depressed Patients Receiving Cognitive Behavioral Therapy. Biological Psychiatry 2005, 59: 284-286. PMID: 16139814, DOI: 10.1016/j.biopsych.2005.07.015.
- Coric V, Taskiran S, Pittenger C, Wasylink S, Mathalon DH, Valentine G, Saksa J, Wu YT, Gueorguieva R, Sanacora G, Malison RT, Krystal JH. Riluzole Augmentation in Treatment-Resistant Obsessive–Compulsive Disorder: An Open-Label Trial. Biological Psychiatry 2005, 58: 424-428. PMID: 15993857, DOI: 10.1016/j.biopsych.2005.04.043.
- Krystal JH, Perry EB, Gueorguieva R, Belger A, Madonick SH, Abi-Dargham A, Cooper TB, MacDougall L, Abi-Saab W, D’Souza D. Comparative and Interactive Human Psychopharmacologic Effects of Ketamine and Amphetamine: Implications for Glutamatergic and Dopaminergic Model Psychoses and Cognitive Function. JAMA Psychiatry 2005, 62: 985-995. PMID: 16143730, DOI: 10.1001/archpsyc.62.9.985.
- Staley JK, Gottschalk C, Petrakis IL, Gueorguieva R, O’Malley S, Baldwin R, Jatlow P, Verhoeff NP, Perry E, Weinzimmer D, Frohlich E, Ruff E, van Dyck CH, Seibyl JP, Innis RB, Krystal JH. Cortical γ-Aminobutyric Acid Type A–Benzodiazepine Receptors in Recovery From Alcohol Dependence: Relationship to Features of Alcohol Dependence and Cigarette Smoking. JAMA Psychiatry 2005, 62: 877-888. PMID: 16061765, DOI: 10.1001/archpsyc.62.8.877.
- Martinez D, Gil R, Slifstein M, Hwang DR, Huang Y, Perez A, Kegeles L, Talbot P, Evans S, Krystal J, Laruelle M, Abi-Dargham A. Alcohol Dependence Is Associated with Blunted Dopamine Transmission in the Ventral Striatum. Biological Psychiatry 2005, 58: 779-786. PMID: 16018986, DOI: 10.1016/j.biopsych.2005.04.044.
- Hoffman RE, Gueorguieva R, Hawkins KA, Varanko M, Boutros NN, Wu YT, Carroll K, Krystal JH. Temporoparietal Transcranial Magnetic Stimulation for Auditory Hallucinations: Safety, Efficacy and Moderators in a Fifty Patient Sample. Biological Psychiatry 2005, 58: 97-104. PMID: 15936729, DOI: 10.1016/j.biopsych.2005.03.041.
- Bressan RA, Erlandsson K, Stone JM, Mulligan RS, Krystal JH, Ell PJ, Pilowsky LS. Impact of Schizophrenia and Chronic Antipsychotic Treatment on [123I]CNS-1261 Binding to N-Methyl-D-Aspartate Receptors In Vivo. Biological Psychiatry 2005, 58: 41-46. PMID: 15992521, DOI: 10.1016/j.biopsych.2005.03.016.
- Kiehl KA, Stevens MC, Celone K, Kurtz M, Krystal JH. Abnormal hemodynamics in schizophrenia during an auditory oddball task. Biological Psychiatry 2005, 57: 1029-1040. PMID: 15860344, PMCID: PMC2771438, DOI: 10.1016/j.biopsych.2005.01.035.
- Lappalainen J, Krupitsky E, Remizov M, Pchelina S, Taraskina A, Zvartau E, Somberg LK, Covault J, Kranzler HR, Krystal JH, Gelernter J. Association Between Alcoholism and γ‐Amino Butyric Acid α2 Receptor Subtype in a Russian Population. Alcohol Clinical And Experimental Research 2005, 29: 493-498. PMID: 15834213, DOI: 10.1097/01.alc.0000158938.97464.90.
- D’Souza D, Abi-Saab WM, Madonick S, Forselius-Bielen K, Doersch A, Braley G, Gueorguieva R, Cooper TB, Krystal JH. Delta-9-tetrahydrocannabinol effects in schizophrenia: Implications for cognition, psychosis, and addiction. Biological Psychiatry 2005, 57: 594-608. PMID: 15780846, DOI: 10.1016/j.biopsych.2004.12.006.
- Kendell SF, Krystal JH, Sanacora G. GABA and glutamate systems as therapeutic targets in depression and mood disorders. Expert Opinion On Therapeutic Targets 2005, 9: 153-168. PMID: 15757488, DOI: 10.1517/14728222.9.1.153.
- Cho HS, D’Souza D, Gueorguieva R, Perry EB, Madonick S, Karper LP, Abi-Dargham A, Belger A, Abi-Saab W, Lipschitz D, Bennet A, Seibyl JP, Krystal JH. Absence of behavioral sensitization in healthy human subjects following repeated exposure to ketamine. Psychopharmacology 2005, 179: 136-143. PMID: 15682309, DOI: 10.1007/s00213-004-2066-5.
- Cavus I, Kasoff WS, Cassaday MP, Jacob R, Gueorguieva R, Sherwin RS, Krystal JH, Spencer DD, Abi‐Saab W. Extracellular metabolites in the cortex and hippocampus of epileptic patients. Annals Of Neurology 2005, 57: 226-235. PMID: 15668975, DOI: 10.1002/ana.20380.
- Perry E, Gil R, Miles D, Brenner L, Macdougall L, Johnson R, Degen K, Gueorguieva R, Petrakis I, Krystal J, D'Souza D. Mazindol Augmentation of Antipsychotic Treatment for Schizophrenic Patients with Comorbid Cocaine Abuse or Dependence. Journal Of Dual Diagnosis 2005, 1: 37-47. DOI: 10.1300/j374v01n01_04.
- Tsoy M, Krupitsky E, Neznanova O, Burakov A, Didenko T, Masalov D, Romanova T, Bespalov A, Zvartau E, Krystal J. P.3.10 Ethanol-like effects of N-methyl-d-aspartatereceptors antagonist memantine, and its ability to prevent cue induced alcohol craving. European Neuropsychopharmacology 2005, 15: s59-s60. DOI: 10.1016/s0924-977x(05)80177-4.
- Mason G, Bendszus M, Meyerhoff D, Hetherington H, Schweinsburg B, Ross B, Taylor M, Krystal J. Magnetic Resonance Spectroscopic Studies of Alcoholism: From Heavy Drinking to Alcohol Dependence and Back Again. Alcohol Clinical And Experimental Research 2005, 29: 150-158. PMID: 15895489, DOI: 10.1097/01.alc.0000150010.72739.58.
- Daurignac E, Toga A, Jones D, Aronen H, Hommer D, Jernigan T, Krystal J, Mathalon D. Applications of Morphometric and Diffusion Tensor Magnetic Resonance Imaging to the Study of Brain Abnormalities in the Alcoholism Spectrum. Alcohol Clinical And Experimental Research 2005, 29: 159-166. PMID: 15895490, DOI: 10.1097/01.alc.0000150891.72900.62.
- Epperson CN, O’Malley S, Czarkowski KA, Gueorguieva R, Jatlow P, Sanacora G, Rothman DL, Krystal JH, Mason GF. Sex, GABA, and nicotine: The impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopy. Biological Psychiatry 2005, 57: 44-48. PMID: 15607299, PMCID: PMC4097033, DOI: 10.1016/j.biopsych.2004.09.021.
- Jacobsen LK, Krystal JH, Mencl WE, Westerveld M, Frost SJ, Pugh KR. Effects of smoking and smoking abstinence on cognition in adolescent tobacco smokers. Biological Psychiatry 2005, 57: 56-66. PMID: 15607301, DOI: 10.1016/j.biopsych.2004.10.022.
- Hoffman R, Mathalon D, Ford J, Krystal J. Cortico – (thalamo) – cortical interactions, gamma resonance, and auditory hallucinations in schizophrenia. Behavioral And Brain Sciences 2004, 27: 797-798. DOI: 10.1017/s0140525x04320182.
- Goddard AW, Mason GF, Appel M, Rothman DL, Gueorguieva R, Behar KL, Krystal JH. Impaired GABA Neuronal Response to Acute Benzodiazepine Administration in Panic Disorder. American Journal Of Psychiatry 2004, 161: 2186-2193. PMID: 15569888, DOI: 10.1176/appi.ajp.161.12.2186.
- Kaufman J, Yang BZ, Douglas-Palumberi H, Houshyar S, Lipschitz D, Krystal JH, Gelernter J. Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 17316-17321. PMID: 15563601, PMCID: PMC534414, DOI: 10.1073/pnas.0404376101.
- Sanacora G, Kendell SF, Fenton L, Coric V, Krystal JH. Riluzole Augmentation for Treatment-Resistant Depression. American Journal Of Psychiatry 2004, 161: 2132-2132. PMID: 15514421, DOI: 10.1176/appi.ajp.161.11.2132.
- Petrakis IL, Limoncelli D, Gueorguieva R, Jatlow P, Boutros NN, Trevisan L, Gelernter J, Krystal JH. Altered NMDA Glutamate Receptor Antagonist Response in Individuals With a Family Vulnerability to Alcoholism. American Journal Of Psychiatry 2004, 161: 1776-1782. PMID: 15465973, DOI: 10.1176/ajp.161.10.1776.
- Krystal JH, Abi-Saab W, Perry E, D’Souza D, Liu N, Gueorguieva R, McDougall L, Hunsberger T, Belger A, Levine L, Breier A. Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects. Psychopharmacology 2004, 179: 303-309. PMID: 15309376, DOI: 10.1007/s00213-004-1982-8.
- Krishnan-Sarin S, Shih J, Krystal J, O’Malley S. HPA AXIS RESPONSIVITY AND ALCOHOL DRINKING: INTERACTIVE EFFECTS OF FAMILY HISTORY OF ALCOHOLISM AND NALTREXONE TREATMENT. Alcohol Clinical And Experimental Research 2004, 28: 73a. DOI: 10.1097/00000374-200408002-00397.
- Krupitsky E, Rudenko A, Burakov A, Zvartau E, Slavina T, Grinenko A, Krystal J. ANTI-GLUTAMATE TREATMENTS FOR ALCOHOL DETOXIFICATION: A DOUBLE-BLIND PLACEBO-CONTROLLED PILOT STUDY OF LAMOTRIGINE, MEMANTINE, AND TOPIRAMATE. Alcohol Clinical And Experimental Research 2004, 28: 50a. DOI: 10.1097/00000374-200408002-00258.
- Malhotra A, Krystal J. Molecular genetics and psychopharmacology. Psychopharmacology 2004, 174: 439-440. DOI: 10.1007/s00213-004-1947-y.
- Sanacora G, Gueorguieva R, Epperson CN, Wu YT, Appel M, Rothman DL, Krystal JH, Mason GF. Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression. JAMA Psychiatry 2004, 61: 705-713. PMID: 15237082, DOI: 10.1001/archpsyc.61.7.705.
- Petrakis I, O’Malley S, Rounsaville B, Poling J, McHugh-Strong C, Krystal J, VA Naltrexone Study Collaboration Group. Naltrexone augmentation of neuroleptic treatment in alcohol abusing patients with schizophrenia. Psychopharmacology 2004, 174: 300-300. DOI: 10.1007/s00213-004-1881-z.
- D'Souza DC, Perry E, MacDougall L, Ammerman Y, Cooper T, Wu YT, Braley G, Gueorguieva R, Krystal JH. The Psychotomimetic Effects of Intravenous Delta-9-Tetrahydrocannabinol in Healthy Individuals: Implications for Psychosis. Neuropsychopharmacology 2004, 29: 1558-1572. PMID: 15173844, DOI: 10.1038/sj.npp.1300496.
- BLUMBERG HP, KAUFMAN J, MARTIN A, CHARNEY DS, KRYSTAL JH, PETERSON BS. Significance of Adolescent Neurodevelopment for the Neural Circuitry of Bipolar Disorder. Annals Of The New York Academy Of Sciences 2004, 1021: 376-383. PMID: 15251913, DOI: 10.1196/annals.1308.048.
- D'souza D, Cho H, Perry E, Krystal J. Cannabinoid ‘model’ psychosis, dopamine–cannabinoid interactions and implications for schizophrenia. 2004, 142-165. DOI: 10.1017/cbo9780511543630.012.
- Cho H, Krystal J, D’Souza D. Blood dyscrasias. 2004, 221-238. DOI: 10.1093/med/9780198527480.003.0012.
- Jacobsen LK, D'Souza DC, Mencl WE, Pugh KR, Skudlarski P, Krystal JH. Nicotine effects on brain function and functional connectivity in schizophrenia. Biological Psychiatry 2004, 55: 850-858. PMID: 15050867, DOI: 10.1016/j.biopsych.2003.12.023.
- Gueorguieva R, Krystal JH. Move Over ANOVA: Progress in Analyzing Repeated-Measures Data andIts Reflection in Papers Published in the Archives of General Psychiatry. JAMA Psychiatry 2004, 61: 310-317. PMID: 14993119, DOI: 10.1001/archpsyc.61.3.310.
- Lappalainen J, Kranzler HR, Petrakis I, Somberg LK, Page G, Krystal JH, Gelernter J. Confirmation and fine mapping of the chromosome 1 alcohol dependence risk locus. Molecular Psychiatry 2004, 9: 312-319. PMID: 15094791, DOI: 10.1038/sj.mp.4001429.
- Family Psychopathology and Magnitude of Reductions in Occipital Cortex GABA Levels in Panic DisorderGoddard AW, Mason GF, Rothman DL, Behar KL, Petroff O, Krystal JH. Family Psychopathology and Magnitude of Reductions in Occipital Cortex GABA Levels in Panic Disorder. Neuropsychopharmacology 2004, 29: 639-640. PMID: 14973435, DOI: 10.1038/sj.npp.1300374.
- Blumberg HP, Kaufman J, Martin A, Whiteman R, Zhang JH, Gore JC, Charney DS, Krystal JH, Peterson BS. Amygdala and Hippocampal Volumes in Adolescents and Adults With Bipolar Disorder. JAMA Psychiatry 2003, 60: 1201-1208. PMID: 14662552, DOI: 10.1001/archpsyc.60.12.1201.
- Heinz A, Schäfer M, Higley J, Krystal J, Goldman D. Neurobiological Correlates of the Disposition and Maintenance of Alcoholism. Pharmacopsychiatry 2003, 36: 255-258. PMID: 14677088, DOI: 10.1055/s-2003-45139.
- Jacobsen LK, Mencl WE, Pugh KR, Skudlarski P, Krystal JH. Preliminary evidence of hippocampal dysfunction in adolescent MDMA (“ecstasy”) users: possible relationship to neurotoxic effects. Psychopharmacology 2003, 173: 383-390. PMID: 14647960, DOI: 10.1007/s00213-003-1679-4.
- Petrakis IL, O’Malley S, Rounsaville B, Poling J, McHugh-Strong C, Krystal JH, VA Naltrexone Study Collaboration Group. Naltrexone augmentation of neuroleptic treatment in alcohol abusing patients with schizophrenia. Psychopharmacology 2003, 172: 291-297. PMID: 14634716, DOI: 10.1007/s00213-003-1658-9.
- Roberts LW, Krystal J. A time of promise, a time of promises: ethical issues in advancing psychopharmacological research. Psychopharmacology 2003, 171: 1-5. PMID: 14615879, DOI: 10.1007/s00213-003-1704-7.
- Qin J, Mitchell K, Johnson M, Krystal J, Southwick S, Rasmusson A, Allen E. Reactions to and memories for the September 11, 2001 terrorist attacks in adults with posttraumatic stress disorder. Applied Cognitive Psychology 2003, 17: 1081-1097. DOI: 10.1002/acp.987.
- SANACORA G, ROTHMAN DL, MASON G, KRYSTAL JH. Clinical Studies Implementing Glutamate Neurotransmission in Mood Disorders. Annals Of The New York Academy Of Sciences 2003, 1003: 292-308. PMID: 14684453, DOI: 10.1196/annals.1300.018.
- KRYSTAL JH, PETRAKIS IL, KRUPITSKY E, SCHÜTZ C, TREVISAN L, D'SOUZA DC. NMDA Receptor Antagonism and the Ethanol Intoxication Signal. Annals Of The New York Academy Of Sciences 2003, 1003: 176-184. PMID: 14684445, DOI: 10.1196/annals.1300.010.
- Krystal J, D'Souza D, Mathalon D, Belger A, Perry E. S.01.03 Therapeutic implications of the NMDA receptor antagonist model psychosis. European Neuropsychopharmacology 2003, 13: s96. DOI: 10.1016/s0924-977x(03)91600-2.
- Rasmusson A, Guidotti A, Charney D, Vojvoda D, Lipschitz D, Weisman D, Krystal J. S.20.01 Adrenal & CSF neurosteroids as mediators of HPA axis upregulation and symptom production in premenopausal women with PTSD. European Neuropsychopharmacology 2003, 13: s151-s152. DOI: 10.1016/s0924-977x(03)91680-4.
- Krystal JH, D'Souza DC, Mathalon D, Perry E, Belger A, Hoffman R. NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development. Psychopharmacology 2003, 169: 215-233. PMID: 12955285, DOI: 10.1007/s00213-003-1582-z.
- Cramer J, Rosenheck R, Kirk G, Krol W, Krystal J, 425 F. Medication Compliance Feedback and Monitoring in a Clinical Trial: Predictors and Outcomes. Value In Health 2003, 6: 566-573. PMID: 14627063, DOI: 10.1046/j.1524-4733.2003.65269.x.
- Harvey PD, Geyer MA, Robbins TW, Krystal JH. Cognition in schizophrenia: from basic science to clinical treatment. Psychopharmacology 2003, 169: 213-214. PMID: 12955286, DOI: 10.1007/s00213-003-1581-0.
- Lappalainen J, Sanacora G, Kranzler HR, Malison R, Hibbard ES, Price LH, Krystal J, Gelernter J. Mutation screen of the glutamate decarboxylase‐67 gene and haplotype association to unipolar depression. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2003, 124B: 81-86. PMID: 14681921, DOI: 10.1002/ajmg.b.20055.
- Mathalon DH, Rapoport JL, Davis KL, Krystal JH. Neurotoxicity, Neuroplasticity, and Magnetic Resonance Imaging Morphometry. JAMA Psychiatry 2003, 60: 846-848. PMID: 12912768, DOI: 10.1001/archpsyc.60.8.846.
- Blumberg HP, Martin A, Kaufman J, Leung HC, Skudlarski P, Lacadie C, Fulbright RK, Gore JC, Charney DS, Krystal JH, Peterson BS. Frontostriatal Abnormalities in Adolescents With Bipolar Disorder: Preliminary Observations From Functional MRI. American Journal Of Psychiatry 2003, 160: 1345-1347. PMID: 12832254, DOI: 10.1176/appi.ajp.160.7.1345.
- Krystal JH, Petrakis IL, Mason G, Trevisan L, D'Souza DC. N-methyl-d-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability. Pharmacology & Therapeutics 2003, 99: 79-94. PMID: 12804700, DOI: 10.1016/s0163-7258(03)00054-8.
- Krystal JH, Petrakis IL, Limoncelli D, Webb E, Gueorgueva R, D'Souza DC, Boutros NN, Trevisan L, Charney DS. Altered NMDA Glutamate Receptor Antagonist Response in Recovering Ethanol-Dependent Patients. Neuropsychopharmacology 2003, 28: 2020-2028. PMID: 12888778, DOI: 10.1038/sj.npp.1300252.
- Blumberg HP, Leung HC, Skudlarski P, Lacadie CM, Fredericks CA, Harris BC, Charney DS, Gore JC, Krystal JH, Peterson BS. A Functional Magnetic Resonance Imaging Study of Bipolar Disorder: State- and Trait-Related Dysfunction in Ventral Prefrontal Cortices. JAMA Psychiatry 2003, 60: 601-609. PMID: 12796223, DOI: 10.1001/archpsyc.60.6.601.
- Morgan CA, Krystal JH, Southwick SM. Toward early pharmacological posttraumatic stress intervention. Biological Psychiatry 2003, 53: 834-843. PMID: 12725976, DOI: 10.1016/s0006-3223(03)00116-1.
- Coric V, Milanovic S, Wasylink S, Patel P, Malison R, Krystal JH. Beneficial effects of the antiglutamatergic agent riluzole in a patient diagnosed with obsessive-compulsive disorder and major depressive disorder. Psychopharmacology 2003, 167: 219-220. PMID: 12658528, DOI: 10.1007/s00213-003-1396-z.
- D'Souza D, Perry E, Riccardi P, Abi-Saab W, Krystal J. Cannabinoids and psychosis: Pharmacological studies with IV delta-9-THC in humans. Schizophrenia Research 2003, 60: 310. DOI: 10.1016/s0920-9964(03)80247-5.
- Jacobsen L, Mencl W, D'Souza D, Pugh K, Skudlarski P, Abi-Saab W, Krystal J. Impact of nicotine on brain function in smokers with schizophrenia. Schizophrenia Research 2003, 60: 223-224. DOI: 10.1016/s0920-9964(03)81196-9.
- Sanacora G, Mason GF, Rothman DL, Hyder F, Ciarcia JJ, Ostroff RB, Berman RM, Krystal JH. Increased Cortical GABA Concentrations in Depressed Patients Receiving ECT. American Journal Of Psychiatry 2003, 160: 577-579. PMID: 12611844, DOI: 10.1176/appi.ajp.160.3.577.
- Moghaddam B, Krystal J. The Neurochemistry of Schizophrenia. 2003, 349-364. DOI: 10.1002/9780470987353.ch19.
- Hoffman RE, Hawkins KA, Gueorguieva R, Boutros NN, Rachid F, Carroll K, Krystal JH. Transcranial Magnetic Stimulation of Left Temporoparietal Cortex and Medication-Resistant Auditory Hallucinations. JAMA Psychiatry 2003, 60: 49-56. PMID: 12511172, DOI: 10.1001/archpsyc.60.1.49.
- Sierra M, Phillips ML, Ivin G, Krystal J, David AS. A placebo-controlled, cross-over trial of lamotrigine in depersonalization disorder. Journal Of Psychopharmacology 2003, 17: 103-105. PMID: 12680746, DOI: 10.1177/0269881103017001712.
- Kane JM, Krystal J, Correll CU. Treatment Models and Designs for Intervention Research During the Psychotic Prodrome. Schizophrenia Bulletin 2003, 29: 747-756. PMID: 14989412, DOI: 10.1093/oxfordjournals.schbul.a007044.
- Blumberg HP, Charney DS, Krystal JH. Frontotemporal neural systems in bipolar disorder. Seminars In Clinical Neuropsychiatry 2002, 7: 243-54. PMID: 12382207, DOI: 10.1053/scnp.2002.35220.
- Epperson CN, Haga K, Mason GF, Sellers E, Gueorguieva R, Zhang W, Weiss E, Rothman DL, Krystal JH. Cortical γ-Aminobutyric Acid Levels Across the Menstrual Cycle in Healthy Women and Those With Premenstrual Dysphoric Disorder: A Proton Magnetic Resonance Spectroscopy Study. JAMA Psychiatry 2002, 59: 851-858. PMID: 12215085, DOI: 10.1001/archpsyc.59.9.851.
- Lappalainen J, Kranzler HR, Malison R, Price LH, Van Dyck C, Rosenheck RA, Cramer J, Southwick S, Charney D, Krystal J, Gelernter J. A Functional Neuropeptide Y Leu7Pro Polymorphism Associated With Alcohol Dependence in a Large Population Sample From the United States. JAMA Psychiatry 2002, 59: 825-831. PMID: 12215082, DOI: 10.1001/archpsyc.59.9.825.
- Krystal J, Petrakis I, D'Souza D, Mason G, Trevisan L. Alcohol and Glutamate Neurotransmission in Humans: Implications for Reward, Dependence, and Treatment. 2002, 0: 389-398. DOI: 10.1385/1-59259-306-2:389.
- Petrakis I, Buonopane A, O???Malley S, Cermik O, Trevisan L, Boutros N, Limoncelli D, Krystal J. The Effect of Tryptophan Depletion on Alcohol Self-Administration in Non-Treatment-Seeking Alcoholic Individuals. Alcohol Clinical And Experimental Research 2002, 26: 969-975. DOI: 10.1097/00000374-200207000-00005.
- Petrakis IL, Buonopane A, O'Malley S, Cermik O, Trevisan L, Boutros NN, Limoncelli D, Krystal JH. The Effect of Tryptophan Depletion on Alcohol Self‐Administration in Non‐Treatment‐Seeking Alcoholic Individuals. Alcohol Clinical And Experimental Research 2002, 26: 969-975. PMID: 12170105, DOI: 10.1111/j.1530-0277.2002.tb02629.x.
- Krystal JH, Anand A, Moghaddam B. Effects of NMDA receptor antagonists: implications for the pathophysiology of schizophrenia. JAMA Psychiatry 2002, 59: 663-4. PMID: 12090822, DOI: 10.1001/archpsyc.59.7.663.
- Cramer J, Rosenheck R, Krystal J, Kirk G, Krol W. PMH1 USEFULNESS OF ELECTRONIC COMPLIANCE DATA IN AN EFFECTIVENESS TRIAL. Value In Health 2002, 5: 226. DOI: 10.1016/s1098-3015(10)61067-4.
- Abi-Saab W, Seibyl JP, D'Souza C, Karper LP, Gueorgueva R, Abi-Dargham A, Wong ML, Rajhans S, Erdos JP, Heninger GR, Charney DS, Krystal JH. Ritanserin antagonism of m-chlorophenylpiperazine effects in neuroleptic-free schizophrenics patients: support for serotonin-2 receptor modulation of schizophrenia symptoms. Psychopharmacology 2002, 162: 55-62. PMID: 12107618, DOI: 10.1007/s00213-002-1057-7.
- Sanacora G, Mason GF, Rothman DL, Krystal JH. Increased Occipital Cortex GABA Concentrations in Depressed Patients After Therapy With Selective Serotonin Reuptake Inhibitors. American Journal Of Psychiatry 2002, 159: 663-665. PMID: 11925309, DOI: 10.1176/appi.ajp.159.4.663.
- Stine SM, Southwick SM, Petrakis IL, Kosten TR, Charney DS, Krystal JH. Yohimbine-induced withdrawal and anxiety symptoms in opioid-dependent patients. Biological Psychiatry 2002, 51: 642-651. PMID: 11955464, DOI: 10.1016/s0006-3223(01)01292-6.
- Boutros NN, Gelernter J, Gooding DC, Cubells J, Young A, Krystal JH, Kosten T. Sensory gating and psychosis vulnerability in cocaine-dependent individuals: preliminary data. Biological Psychiatry 2002, 51: 683-686. PMID: 11955469, DOI: 10.1016/s0006-3223(01)01237-9.
- Abi-Saab WM, Maggs DG, Jones T, Jacob R, Srihari V, Thompson J, Kerr D, Leone P, Krystal JH, Spencer DD, During MJ, Sherwin RS. Striking Differences in Glucose and Lactate Levels Between Brain Extracellular Fluid and Plasma in Conscious Human Subjects: Effects of Hyperglycemia and Hypoglycemia. Cerebrovascular And Brain Metabolism Reviews 2002, 22: 271-279. PMID: 11891432, DOI: 10.1097/00004647-200203000-00004.
- Jacobsen LK, Gore JC, Skudlarski P, Lacadie CM, Jatlow P, Krystal JH. Impact of intravenous nicotine on BOLD signal response to photic stimulation. Magnetic Resonance Imaging 2002, 20: 141-145. PMID: 12034334, DOI: 10.1016/s0730-725x(02)00494-0.
- Krystal J, Petrakis I, D’Souza D, Mason G, Trevisan L. Alcohol and Glutamate Neurotransmission in Humans. Contemporary Clinical Neuroscience 2002, 389-397. DOI: 10.1007/978-1-59259-306-4_26.
- Commentary: first, do no harm. Then, do some good: ethics and human experimental psychopharmacology.Krystal JH. Commentary: first, do no harm. Then, do some good: ethics and human experimental psychopharmacology. Israel Journal Of Psychiatry And Related Sciences 2002, 39: 89-91. PMID: 12227233.
- Krystal JH, Sanacora G, Blumberg H, Anand A, Charney DS, Marek G, Epperson CN, Goddard A, Mason GF. Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments. Molecular Psychiatry 2002, 7: s71-s80. PMID: 11986998, DOI: 10.1038/sj.mp.4001021.
- Krystal J, Cramer J, Krol W, Kirk G, Rosenheck R. Naltrexone in the Treatment of Alcohol Dependence. New England Journal Of Medicine 2001, 345: 1734-1739. PMID: 11742047, DOI: 10.1056/nejmoa011127.
- Sierra M, Phillips M, Lambert M, Senior C, David A, Krystal J. Lamotrigine in the treatment of depersonalization disorder. The Journal Of Clinical Psychiatry 2001, 62: 826-7. PMID: 11816874, DOI: 10.4088/jcp.v62n1012b.
- Krystal J, D’Souza D. Comment on “ketamine has equal affinity for NMDA receptors and the high-affinity state of the dopamine D2 receptor”. Biological Psychiatry 2001, 50: 555. PMID: 11600110, DOI: 10.1016/s0006-3223(01)01258-6.
- Newcomer J, Krystal J. NMDA receptor regulation of memory and behavior in humans. Hippocampus 2001, 11: 529-542. PMID: 11732706, DOI: 10.1002/hipo.1069.
- Krupitsky E, Burakov A, Romanova T, Grinenko N, Grinenko A, Fletcher J, Petrakis I, Krystal J. Attenuation of Ketamine Effects by Nimodipine Pretreatment in Recovering Ethanol Dependent Men: Psychopharmacologic Implications of the Interaction of NMDA and L-Type Calcium Channel Antagonists. Neuropsychopharmacology 2001, 25: 936-947. PMID: 11750186, DOI: 10.1016/s0893-133x(01)00346-3.
- Petrakis I, Trevisan L, Boutros N, Limoncelli D, Cooney N, Krystal J. Effect of Tryptophan Depletion on Alcohol Cue-Induced Craving in Abstinent Alcoholic Patients. Alcohol Clinical And Experimental Research 2001, 25: 1151-1155. DOI: 10.1097/00000374-200108000-00009.
- Petrakis I, Trevisan L, Boutros N, Limoncelli D, Cooney N, Krystal J. Effect of Tryptophan Depletion on Alcohol Cue‐Induced Craving in Abstinent Alcoholic Patients. Alcohol Clinical And Experimental Research 2001, 25: 1151-1155. PMID: 11505046, DOI: 10.1111/j.1530-0277.2001.tb02329.x.
- Chambers R, Krystal J, Self D. A neurobiological basis for substance abuse comorbidity in schizophrenia. Biological Psychiatry 2001, 50: 71-83. PMID: 11526998, PMCID: PMC2913410, DOI: 10.1016/s0006-3223(01)01134-9.
- Goddard AW, Mason GF, Almai A, Rothman DL, Behar KL, Petroff OA, Charney DS, Krystal JH. Reductions in Occipital Cortex GABA Levels in Panic Disorder Detected With 1H-Magnetic Resonance Spectroscopy. JAMA Psychiatry 2001, 58: 556-561. PMID: 11386984, DOI: 10.1001/archpsyc.58.6.556.
- Mason G, Behar K, Krystal J, Rothman D. Aplicações da ressonância magnética para medidas espectroscópicas da neurotransmissão. Brazilian Journal Of Psychiatry 2001, 23: 6-10. DOI: 10.1590/s1516-44462001000500004.
- Krystal J, D'Souza D, Sanacora G, Goddard A, Charney D. CURRENT PERSPECTIVES ON THE PATHOPHYSIOLOGY OF SCHIZOPHRENIA, DEPRESSION, AND ANXIETY DISORDERS. Medical Clinics Of North America 2001, 85: 559-577. PMID: 11349473, DOI: 10.1016/s0025-7125(05)70329-1.
- Stine S, Grillon C, Morgan III C, Kosten T, Charney D, Krystal J. Methadone patients exhibit increased startle and cortisol response after intravenous yohimbine. Psychopharmacology 2001, 154: 274-281. PMID: 11351934, DOI: 10.1007/s002130000644.
- Jacobsen LK, Giedd JN, Gottschalk C, Kosten TR, Krystal JH. Quantitative Morphology of the Caudate and Putamen in Patients With Cocaine Dependence. American Journal Of Psychiatry 2001, 158: 486-489. PMID: 11229995, DOI: 10.1176/appi.ajp.158.3.486.
- D'Souza D, Krystal J. Psychopharmacological challenge studies in psychiatric research. International Review Of Psychiatry 2001, 13: 40-46. DOI: 10.1080/09540260020024187.
- Boutros N, Lisanby S, Tokuno H, Torello M, Campbell D, Berman R, Malison R, Krystal J, Kosten T. Elevated motor threshold in drug-free, cocaine-dependent patients assessed with transcranial magnetic stimulation. Biological Psychiatry 2001, 49: 369-373. PMID: 11239908, DOI: 10.1016/s0006-3223(00)00948-3.
- D'Souza D, Krystal J. Psychopharmacological challenge studies in psychiatric research. International Review Of Psychiatry 2001, 13: 40-46. DOI: 10.1080/09540260123077.
- Boutros N, Reid M, Petrakis I, Campbell D, Torello M, Krystal J. Similarities in the Disturbances in Cortical Information Processing in Alcoholism and Aging: A Pilot Evoked Potential Study,. International Psychogeriatrics 2000, 12: 513-525. PMID: 11263717, DOI: 10.1017/s1041610200006621.
- Krystal J, Belger A, Abi-Saab W, Moghaddam B, Charney D, Anand A, Madonick S, D’Souza C. Glutamatergic contributions to cognitive dysfunction in schizophrenia. 2000, 126-153. DOI: 10.1093/oso/9780192629937.003.0007.
- Boutros N, Campbell D, Petrakis I, Krystal J, Caporale M, Kosten T. Cocaine use and the mid-latency auditory evoked responses. Psychiatry Research 2000, 96: 117-126. PMID: 11063784, DOI: 10.1016/s0165-1781(00)00207-9.
- Abi-Dargham A, Krystal J. Serotonin Receptors as Targets of Antipsychotic Medications. Handbooks In Pharmacology And Toxicology 2000, 20000744: 79-107. DOI: 10.1201/9781420041774.ch6.
- George T, Krystal J. Comorbidity of psychiatric and substance abuse disorders. Current Opinion In Psychiatry 2000, 13: 327-331. DOI: 10.1097/00001504-200005000-00015.
- Belger A, Krystal J. 203. Working memory: constructs, neural circuits, and pharmacological modulation. Biological Psychiatry 2000, 47: s62. DOI: 10.1016/s0006-3223(00)00295-x.
- Abi-Saab W, Spencer D, Srihari V, Thompson J, Roth R, Sherwin R, Krystal J. 458. Extracellular levels of GABA and glutamate increase in response to direct electrical stimulation of the hippocampus in humans: an in vivo microdialysis study. Biological Psychiatry 2000, 47: s140. DOI: 10.1016/s0006-3223(00)00728-9.
- Hoffman R, Boutros N, Berman R, Hu S, Rachid F, Schaffer N, Krystal J, Charney D. 401. One Hertz rTMS of left temporoparietal cortex in schizophrenic patients reporting auditory hallucinations. Biological Psychiatry 2000, 47: s122-s123. DOI: 10.1016/s0006-3223(00)00670-3.
- Boutros N, Reid C, Campbell D, Torello M, Krystal J. 455. Sensory gating in older healthy adults. Biological Psychiatry 2000, 47: s139. DOI: 10.1016/s0006-3223(00)00725-3.
- Hoffman R, Boutros N, Hu S, Berman R, Krystal J, Charney D. Transcranial magnetic stimulation and auditory hallucinations in schizophrenia. The Lancet 2000, 355: 1073-1075. PMID: 10744097, DOI: 10.1016/s0140-6736(00)02043-2.
- Laruelle M, Abi-Dargham A, van Dyck C, Gil R, D’Souza D, Krystal J, Seibyl J, Baldwin R, Innis R. Dopamine and serotonin transporters in patients with schizophrenia: an imaging study with [123I]β-CIT. Biological Psychiatry 2000, 47: 371-379. PMID: 10704949, DOI: 10.1016/s0006-3223(99)00257-7.
- D’Souza D, Gil R, Cassello K, Morrissey K, Abi-Saab D, White J, Sturwold R, Bennett A, Karper L, Zuzarte E, Charney D, Krystal J. IV glycine and oral d-cycloserine effects on plasma and CSF amino acids in healthy humans. Biological Psychiatry 2000, 47: 450-462. PMID: 10704956, DOI: 10.1016/s0006-3223(99)00133-x.
- Anand A, Charney DS, Oren DA, Berman RM, Hu XS, Cappiello A, Krystal JH. Attenuation of the Neuropsychiatric Effects of Ketamine With Lamotrigine: Support for Hyperglutamatergic Effects of N-methyl-D-aspartate Receptor Antagonists. JAMA Psychiatry 2000, 57: 270-276. PMID: 10711913, DOI: 10.1001/archpsyc.57.3.270.
- Berman R, Cappiello A, Anand A, Oren D, Heninger G, Charney D, Krystal J. Antidepressant effects of ketamine in depressed patients. Biological Psychiatry 2000, 47: 351-354. PMID: 10686270, DOI: 10.1016/s0006-3223(99)00230-9.
- Krystal J, Bremner J, D’Souza D, Anand A, Southwick S, Charney D. The Emerging Neurobiology of Dissociative States. Springer Series On Stress And Coping 2000, 307-320. DOI: 10.1007/978-1-4615-4177-6_22.
- D'Souza D, Abi-Saab W, Madonick S, Wray Y, Forselius K, MacDougall L, Brush L, Cassello K, Krystal J. Cannabinoids & psychosis: Evidence from studies with I.V THC in schizophrenic patients and controls. Schizophrenia Research 2000, 41: 33. DOI: 10.1016/s0920-9964(00)90371-2.
- D'Souza D, Madonick S, Abi-Saab W, Wray Y, MacDougall L, Brush L, Cassello K, Krystal J. Dose-response of acute ethanol administration in schizophrenic patients and controls. Schizophrenia Research 2000, 41: 247. DOI: 10.1016/s0920-9964(00)90923-x.
- Krystal J, D'Souza D, Belger A, Madonick S, Cossello K. Ketamine and amphetamine interactions in healthy humans: Further insights into glutamate-dopamine interactions. Schizophrenia Research 2000, 41: 235-236. DOI: 10.1016/s0920-9964(00)90891-0.
- Anand A, Berman R, Charney D, Krystal J. Attenuation of ketamine effects in healthy humans by lamotrigine, a drug that reduces glutamate release. Schizophrenia Research 2000, 41: 33. DOI: 10.1016/s0920-9964(00)90372-4.
- Krystal J, Bennett A, Abi-Saab D, Belger A, Karper L, D’Souza D, Lipschitz D, Abi-Dargham A, Charney D. Dissociation of ketamine effects on rule acquisition and rule implementation: possible relevance to NMDA receptor contributions to executive cognitive functions. Biological Psychiatry 2000, 47: 137-143. PMID: 10664830, PMCID: PMC10060085, DOI: 10.1016/s0006-3223(99)00097-9.
- Sanacora G, Mason G, Krystal J. Impairment of GABAergic Transmission in Depression: New Insights from Neuroimaging Studies. Critical Reviews In Neurobiology 2000, 14: 23. PMID: 11253954, DOI: 10.1615/critrevneurobiol.v14.i1.20.
- Krystal J, Belger A, D'Souza D, Anand A, Charney D, Aghajanian G, Moghaddam B. Therapeutic Implications of the Hyperglutamatergic Effects of NMDA Antagonists. Neuropsychopharmacology 1999, 21: s143-s157. DOI: 10.1016/s0893-133x(99)00102-5.
- Gibbons R, Brown B, Azarnoff D, Bunney W, Cancro R, Gillin J, Hullett S, Killam K, Krystal J, Kupfer D, Stolley P, Pope A, French G. Assessment of the Safety and Efficacy Data for the Hypnotic Halcion (R) : Results of an Analysis by an Institute of Medicine Committee. Journal Of The American Statistical Association 1999, 94: 993. DOI: 10.2307/2669913.
- Gibbons R, Brown B, Azarnoff D, Bunney W, Cancro R, Gillin J, Hullett S, Killam K, Krystal J, Kupfer D, Stolley P, Pope A, French G. Assessment of the Safety and Efficacy Data for the Hypnotic Halcion(R): Results of an Analysis by an Institute of Medicine Committee. Journal Of The American Statistical Association 1999, 94: 993-1002. DOI: 10.1080/01621459.1999.10473852.
- Boutros N, Belger A, Campbell D, D’Souza C, Krystal J. Comparison of four components of sensory gating in schizophrenia and normal subjects: a preliminary report. Psychiatry Research 1999, 88: 119-130. PMID: 10622348, DOI: 10.1016/s0165-1781(99)00074-8.
- Sanacora G, Mason GF, Rothman DL, Behar KL, Hyder F, Petroff OA, Berman RM, Charney DS, Krystal JH. Reduced Cortical γ-Aminobutyric Acid Levels in Depressed Patients Determined by Proton Magnetic Resonance Spectroscopy. JAMA Psychiatry 1999, 56: 1043-1047. PMID: 10565505, DOI: 10.1001/archpsyc.56.11.1043.
- D’Souza D, Berman R, Krystal J, Charney D. Symptom provocation studies in psychiatric disorders: scientific value, risks, and future. Biological Psychiatry 1999, 46: 1060-1080. PMID: 10536743, DOI: 10.1016/s0006-3223(99)00209-7.
- Verhoeff N, Soares J, D’Souza C, Gil R, Degen K, Abi-Dargham A, Zoghbi S, Fujita M, Rajeevan N, Seibyl J, Krystal J, van Dyck C, Charney D, Innis R. [123I]Iomazenil SPECT benzodiazepine receptor imaging in schizophrenia. Psychiatry Research 1999, 91: 163-173. PMID: 10641580, DOI: 10.1016/s0925-4927(99)00027-x.
- Southwick SM, Paige S, Morgan CA, Bremner JD, Krystal JH, Charney DS. Neurotransmitter alterations in PTSD: catecholamines and serotonin. Seminars In Clinical Neuropsychiatry 1999, 4: 242-8. PMID: 10553029, DOI: 10.153/scnp00400242.
- Chambers RA, Bremner JD, Moghaddam B, Southwick SM, Charney DS, Krystal JH. Glutamate and post-traumatic stress disorder: toward a psychobiology of dissociation. Seminars In Clinical Neuropsychiatry 1999, 4: 274-81. PMID: 10553033, DOI: 10.153/scnp00400274.
- Krystal J. NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disorders. Harvard Review Of Psychiatry 1999, 7: 125-143. DOI: 10.1093/hrp/7.3.125.
- Krupitsky E, Burakov A, Romanova T, Vegso S, Krystal J. Nimodipine attenuates psychotigenic effects of ketamine in humans. European Neuropsychopharmacology 1999, 9: 347. DOI: 10.1016/s0924-977x(99)80514-8.
- Krystal J, D'Souza C, Petrakis I, Belger A, Berman R, Charney D, AbiSaab W, Madonick S. NMDA Agonists and Antagonists as Probes of Glutamatergic Dysfunction and Pharmacotherapies in Neuropsychiatric Disorders. Harvard Review Of Psychiatry 1999, 7: 125-143. PMID: 10483932, DOI: 10.3109/hrp.7.3.125.
- Petrakis I, Trevisan L, D'Souza C, Gil R, Krasnicki S, Webb E, Heninger G, Cooney N, Krystal J. CSF Monoamine Metabolite and Beta Endorphin Levels in Recently Detoxified Alcoholics and Healthy Controls. Alcohol Clinical And Experimental Research 1999, 23: 1336. DOI: 10.1097/00000374-199908000-00007.
- Petrakis I, Trevisan L, D'Souza C, Gil R, Krasnicki S, Webb E, Heninger G, Cooney N, Krystal J. CSF Monoamine Metabolite and Beta Endorphin Levels in Recently Detoxified Alcoholics and Healthy Controls: Prediction of Alcohol Cue‐Induced Craving? Alcohol Clinical And Experimental Research 1999, 23: 1336-1341. PMID: 10470976, DOI: 10.1111/j.1530-0277.1999.tb04355.x.
- Hoffman R, Boutros N, Berman R, Roessler E, Belger A, Krystal J, Charney D. Transcranial magnetic stimulation of left temporoparietal cortex in three patients reporting hallucinated “voices”. Biological Psychiatry 1999, 46: 130-132. PMID: 10394483, DOI: 10.1016/s0006-3223(98)00358-8.
- Delgado P, Miller H, Salomon R, Licinio J, Krystal J, Moreno F, Heninger G, Charney D. Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action. Biological Psychiatry 1999, 46: 212-220. PMID: 10418696, DOI: 10.1016/s0006-3223(99)00014-1.
- Krystal J, D’Souza D, Karper L, Bennett A, Abi-Dargham A, Abi-Saab D, Cassello K, Bowers Jr. M, Vegso S, Heninger G, Charney D, Bowers M. Interactive effects of subanesthetic ketamine and haloperidol in healthy humans. Psychopharmacology 1999, 145: 193-204. PMID: 10463321, DOI: 10.1007/s002130051049.
- Abi-Dargham A, Laruelle M, Krystal J, D'Souza C, Zoghbi S, Baldwin R, Seibyl J, Mawlawi O, de Erasquin G, Charney D, Innis R. No Evidence of Altered In Vivo Benzodiazepine Receptor Binding in Schizophrenia. Neuropsychopharmacology 1999, 20: 650-661. PMID: 10327433, DOI: 10.1016/s0893-133x(98)00107-9.
- Behar KL, Rothman DL, Petersen KF, Hooten M, Delaney R, Petroff OA, Shulman GI, Navarro V, Petrakis IL, Charney DS, Krystal JH. Preliminary Evidence of Low Cortical GABA Levels in Localized 1H-MR Spectra of Alcohol-Dependent and Hepatic Encephalopathy Patients. American Journal Of Psychiatry 1999, 156: 952-954. PMID: 10360140, DOI: 10.1176/ajp.156.6.952.
- Sanacora G, Rothman D, Krystal J. Applications of Magnetic Resonance Spectroscopy to Psychiatry. The Neuroscientist 1999, 5: 192-196. DOI: 10.1177/107385849900500316.
- Bunney W, Azarnoff D, Brown B, Cancro R, Gibbons R, Gillin J, Hullett S, Killam K, Kupfer D, Krystal J, Stolley P, French G, Pope A. Report of the Institute of Medicine Committee on the Efficacy and Safety of Halcion. JAMA Psychiatry 1999, 56: 349-352. PMID: 10197830, DOI: 10.1001/archpsyc.56.4.349.
- Sanacora G, Mason G, Rothman D, Berman R, Charney D, Ciarcia J, Krystal J. 1. ECT Effects on Cortical GABA Levels as Determined by 1H-MRS. Journal Of Ect 1999, 15: 102. DOI: 10.1097/00124509-199903000-00009.
- Krystal J, D'Souza D, Madonick S, Petrakis I. Toward a rational pharmacotherapy of comorbid substance abuse in schizophrenic patients. Schizophrenia Research 1999, 35: s35-s49. PMID: 10190224, DOI: 10.1016/s0920-9964(98)00162-5.
- Fujita M, Woods S, Verhoeff N, Abi-Dargham A, Baldwin R, Zoghbi S, Soares J, Jatlow P, Krystal J, Rajeevan N, Charney D, Seibyl J, Innis R. Changes of benzodiazepine receptors during chronic benzodiazepine administration in humans. European Journal Of Pharmacology 1999, 368: 161-172. PMID: 10193652, DOI: 10.1016/s0014-2999(99)00013-8.
- Belger A, Puce A, Krystal J, Gore J, Goldman‐Rakic P, McCarthy G. Dissociation of mnemonic and perceptual processes during spatial and nonspatial working memory using fMRI. Human Brain Mapping 1998, 6: 14-32. PMID: 9673660, PMCID: PMC6873355, DOI: 10.1002/(sici)1097-0193(1998)6:1<14::aid-hbm2>3.0.co;2-o.
- Krystal JH, D'Souza DC. Editorial. Biological Psychiatry 1998, 44: 1075-1076. PMID: 9836009, DOI: 10.1016/s0006-3223(98)00284-4.
- Abi-Dargham A, Krystal JH, Anjilvel S, Scanley BE, Zoghbi S, Baldwin RM, Rajeevan N, Ellis S, Petrakis IL, Seibyl JP, Charney DS, Laruelle M, Innis RB. Alterations of Benzodiazepine Receptors in Type II Alcoholic Subjects Measured With SPECT and 123IIomazenil. American Journal Of Psychiatry 1998, 155: 1550-1555. PMID: 9812116, DOI: 10.1176/ajp.155.11.1550.
- Abi-Saab W, D'Souza D, Moghaddam B, Krystal J. The NMDA Antagonist Model for Schizophrenia: Promise and Pitfalls. Pharmacopsychiatry 1998, 31: 104-109. PMID: 9754841, DOI: 10.1055/s-2007-979354.
- Sernyak M, Glazer W, Heninger G, Charney D, Woods S, Petrakis I, Krystal J, Price L. Naltrexone Augmentation of Neuroleptics in Schizophrenia. Journal Of Clinical Psychopharmacology 1998, 18: 248-251.. PMID: 9617985, DOI: 10.1097/00004714-199806000-00011.
- Abi-Dargham A, Gil R, Krystal J, Baldwin RM, Seibyl JP, Bowers M, van Dyck CH, Charney DS, Innis RB, Laruelle M. Increased Striatal Dopamine Transmission in Schizophrenia: Confirmation in a Second Cohort. American Journal Of Psychiatry 1998, 155: 761-767. PMID: 9619147, DOI: 10.1176/ajp.155.6.761.
- Krystal J, Moghaddam B, Breier A, Goldman-Rakic P, McElvey J. 204. Glutamate, dopamine, the frontal cortex, and schizophrenia. Biological Psychiatry 1998, 43: s60. DOI: 10.1016/s0006-3223(98)90652-7.
- D'Souza D, Belger A, Abi-Saab W, Adams S, Gil R, Larvey K, Cassello K, Sernyak M, Krystal J. 435. Dose-response of THC effects in schizophrenics and healthy controls. Biological Psychiatry 1998, 43: s130-s131. DOI: 10.1016/s0006-3223(98)90883-6.
- Boutros N, Krystal J, Gelernter J. 295. Sensory gating and cocaine induced paranoia. Biological Psychiatry 1998, 43: s89. DOI: 10.1016/s0006-3223(98)90743-0.
- Hoffman R, Boutros N, Berman R, Krystal J, Charney D. 310. Transcranial magnetic stimulation and hallucinated ‘voices’. Biological Psychiatry 1998, 43: s93. DOI: 10.1016/s0006-3223(98)90758-2.
- Krystal JH, Petrakis IL, Webb E, Cooney NL, Karper LP, Namanworth S, Stetson P, Trevisan LA, Charney DS. Dose-Related Ethanol-like Effects of the NMDA Antagonist, Ketamine, in Recently Detoxified Alcoholics. JAMA Psychiatry 1998, 55: 354-360. PMID: 9554431, DOI: 10.1001/archpsyc.55.4.354.
- Hillbrand M, Spitz R, Foster H, Krystal J, Young J. Creatine Kinase Elevations and Aggressive Behavior in Hospitalized Forensic Patients. Psychiatric Quarterly 1998, 69: 69-82. PMID: 9536476, DOI: 10.1023/a:1022137524475.
- Belger A, Kirino E, McCarthy G, Gore J, Krystal J. Assessment of prefrontal activation by infrequent visual targets and non-target novel stimuli in schizophrenia: A functional MRI study. Schizophrenia Research 1998, 29: 106. DOI: 10.1016/s0920-9964(97)88567-2.
- Krystal J, Nagy L, Rasmusson A, Morgan A, Cottrol C, Southwick S, Charney D. Initial Clinical Evidence of Genetic Contributions to Posttraumatic Stress Disorder. Springer Series On Stress And Coping 1998, 657-667. DOI: 10.1007/978-1-4757-5567-1_39.
- Krystal J. Excitatory Amino Acids: Clinical Results with Antagonists. The Yale Journal Of Biology And Medicine 1998, 71: 409-410. PMCID: PMC2578927.
- Measurement of dissociative states with the Clinician‐Administered Dissociative States Scale (CADSS)Bremner J, Krystal J, Putnam F, Southwick S, Marmar C, Charney D, Mazure C. Measurement of dissociative states with the Clinician‐Administered Dissociative States Scale (CADSS). Journal Of Traumatic Stress 1998, 11: 125-136. PMID: 9479681, DOI: 10.1023/a:1024465317902.
- Krystal J, Karper L, Bennett A, D’Souza D, Abi-Dargham A, Morrissey K, Abi-Saab D, Bremner J, Bowers Jr. M, Suckow R, Stetson P, Heninger G, Charney D. Interactive effects of subanesthetic ketamine and subhypnotic lorazepam in humans. Psychopharmacology 1998, 135: 213-229. PMID: 9498724, DOI: 10.1007/s002130050503.
- Trevisan LA, Boutros N, Petrakis IL, Krystal JH. Complications of alcohol withdrawal: pathophysiological insights. Alcohol Research 1998, 22: 61-6. PMID: 15706735, PMCID: PMC6761825.
- Abi-Dargham A, Charney D, Krystal J. Benzodiazepine Receptor Antagonists. CNS Drugs 1997, 8: 244-256. DOI: 10.2165/00023210-199708030-00007.
- Stine S, Krystal J, Petrakis I, Jatlow P, Heninger G, Kosten T, Chamey D. Effect of alpha-methyl-para-tyrosine on response to cocaine challenge. Biological Psychiatry 1997, 42: 181-190. PMID: 9232210, DOI: 10.1016/s0006-3223(96)00331-9.
- Southwick SM, Krystal JH, Bremner JD, Morgan CA, Nicolaou AL, Nagy LM, Johnson DR, Heninger GR, Charney DS. Noradrenergic and Serotonergic Function in Posttraumatic Stress Disorder. JAMA Psychiatry 1997, 54: 749-758. PMID: 9283511, DOI: 10.1001/archpsyc.1997.01830200083012.
- Cramer J, Krystal J, Rosenheck R, Rounsaville B, Krol W, Collins J. P111 Protocol enhancements for a study of alcohol-dependent patients. Contemporary Clinical Trials 1997, 18: s179. DOI: 10.1016/s0197-2456(97)91206-x.
- Krystal J, Webb E, Grillon C, Cooney N, Casal L, Morgan III. C, Southwick S, Davis M, Charney D. Evidence of acoustic startle hyperreflexia in recently detoxified early onset male alcoholics: modulation by yohimbine and m-Chlorophenylpiperazine (mCPP). Psychopharmacology 1997, 131: 207-215. PMID: 9203230, DOI: 10.1007/s002130050285.
- SOUTHWICK S, MORGAN CA, BREMNER A, GRILLON C, KRYSTAL J, NAGY L, CHARNEY D. Noradrenergic Alterations in Posttraumatic Stress Disorder. Annals Of The New York Academy Of Sciences 1997, 821: 125-141. PMID: 9238199, DOI: 10.1111/j.1749-6632.1997.tb48274.x.
- Bremner JD, Licinio J, Darnell A, Krystal JH, Owens MJ, Southwick SM, Nemeroff CB, Charney DS. Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder. American Journal Of Psychiatry 1997, 154: 624-629. PMID: 9137116, PMCID: PMC3233756, DOI: 10.1176/ajp.154.5.624.
- Bremner JD, Innis RB, Salomon RM, Staib LH, Ng CK, Miller HL, Bronen RA, Krystal JH, Duncan J, Rich D, Price LH, Malison R, Dey H, Soufer R, Charney DS. Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Tryptophan Depletion—Induced Depressive Relapse. JAMA Psychiatry 1997, 54: 364-374. PMID: 9107153, DOI: 10.1001/archpsyc.1997.01830160092012.
- Bremner JD, Innis RB, Ng CK, Staib LH, Salomon RM, Bronen RA, Duncan J, Southwick SM, Krystal JH, Rich D, Zubal G, Dey H, Soufer R, Charney DS. Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Yohimbine Administration in Combat-Related Posttraumatic Stress Disorder. JAMA Psychiatry 1997, 54: 246-254. PMID: 9075465, DOI: 10.1001/archpsyc.1997.01830150070011.
- Abi-Dargham A, Laruelle M, Aghajanian GK, Charney D, Krystal J. The role of serotonin in the pathophysiology and treatment of schizophrenia. Journal Of Neuropsychiatry 1997, 9: 1-17. PMID: 9017523, DOI: 10.1176/jnp.9.1.1.
- D’Souza D, Gil R, Zuzarte E, Zimmerman L, Abi-Saab D, Damon D, White J, Semyak M, Krystal J. 602 Tetrahydrocannabinol effects in schizophrenic subjects & healthy controls. Schizophrenia Research 1997, 24: 213. DOI: 10.1016/s0920-9964(97)82610-2.
- Zuzarte E, D’Souza D, Gil R, Genovese A, White J, Charney D, Krystal J. 617 Dose-related ethanol effects in schizophrenic patients. Schizophrenia Research 1997, 24: 218. DOI: 10.1016/s0920-9964(97)82625-4.
- Behar K, Rothman D, D’Souza D, Gil R, Petroff O, Abi-Saab D, Zuzarte E, Hooten M, Petrakis I, Sernyak M, White J, Webb E, Charnay D, Krystal J. 496 Preliminary assessment of cortical gaba levels in schizophrenics using magnetic resonance spectroscopy. Schizophrenia Research 1997, 24: 175-176. DOI: 10.1016/s0920-9964(97)82504-2.
- Laruelle M, Abi-Dargham A, Krystal J, Charney D, Innis R. 507 In vivo evaluation of dopamine synaptic funcflon in untreated schizophrenic patients. Schizophrenia Research 1997, 24: 179. DOI: 10.1016/s0920-9964(97)82515-7.
- Zuzarte E, D’Souza D, Gil R, White J, AbiSaab D, Charney D, Krystal J. 618 Evaluation of lorazepam blockade of M-chlorophenylpiperazine (MCPP) effects in schizophrenia. Schizophrenia Research 1997, 24: 218. DOI: 10.1016/s0920-9964(97)82626-6.
- D’Souza D, Gil R, Zuzarte E, Abi-Saab D, Damon D, White J, Zimmerman L, Krystal J. 601 Glycine ketamine interactions in healthy humans. Schizophrenia Research 1997, 24: 213. DOI: 10.1016/s0920-9964(97)82609-6.
- Belger A, Taqqu Y, Krystal J. 357 Behavioral dissociation of working memory and selective attention functions in schizophrenia. Schizophrenia Research 1997, 24: 129-130. DOI: 10.1016/s0920-9964(97)82365-1.
- Belger A, McNulty A, Krystal J. 356 Behavioral assessment of frontal/ cingulate attention deficits in schizophrenia. Schizophrenia Research 1997, 24: 129. DOI: 10.1016/s0920-9964(97)82364-x.
- Salomon R, Miller H, Krystal J, Heninger G, Charney D. Lack of behavioral effects of monoamine depletion in healthy subjects. Biological Psychiatry 1997, 41: 58-64. PMID: 8988796, DOI: 10.1016/0006-3223(95)00670-2.
- Petrakis I, Krystal J. Neuroscience: implications for treatment. Alcohol Research 1997, 21: 157-60. PMID: 15704353, PMCID: PMC6826829.
- Petrakis I, Satel S, Stine S, Kosten T, Namanworth S, Charney D, Krystal J. AMPT Effects on Cue‐Induced Craving for Cocaine. American Journal On Addictions 1996, 5: 313-320. DOI: 10.1111/j.1521-0391.1996.tb00317.x.
- Laruelle M, Abi-Dargham A, van Dyck CH, Gil R, D'Souza CD, Erdos J, McCance E, Rosenblatt W, Fingado C, Zoghbi SS, Baldwin RM, Seibyl JP, Krystal JH, Charney DS, Innis RB. Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 9235-9240. PMID: 8799184, PMCID: PMC38625, DOI: 10.1073/pnas.93.17.9235.
- McCarthy G, Puce A, Constable T, Krystal J, Gore J, Goldman-Rakic P. Activation of Human Prefrontal Cortex during Spatial and Nonspatial Working Memory Tasks Measured by Functional MRI. Cerebral Cortex 1996, 6: 600-611. PMID: 8670685, DOI: 10.1093/cercor/6.4.600.
- Bremner JD, Krystal JH, Charney DS, Southwick SM. Neural Mechanisms in dissociative amnesia for childhood abuse: relevance to the current controversy surrounding the "false memory syndrome". American Journal Of Psychiatry 1996, 153: 71-82. PMID: 8659644, DOI: 10.1176/ajp.153.7.71.
- D’Souza D, Abi-Saab D, Damon D, White J, Gil R, Krystal J. O-22-11 Dose response of D-Cycloserine, a partial NMDA-Glycine site agonist, in schizophrenia. European Neuropsychopharmacology 1996, 6: 149. DOI: 10.1016/0924-977x(96)87994-6.
- Bremner J, Krystal J, Southwick S, Charney D. Noradrenergic mechanisms in stress and anxiety: I. preclinical studies. Synapse 1996, 23: 28-38. PMID: 8723133, DOI: 10.1002/(sici)1098-2396(199605)23:1<28::aid-syn4>3.0.co;2-j.
- Bremner J, Krystal J, Southwick S, Charney D. Noradrenergic mechanisms in stress and anxiety: II. Clinical studies. Synapse 1996, 23: 39-51. PMID: 8723134, DOI: 10.1002/(sici)1098-2396(199605)23:1<39::aid-syn5>3.0.co;2-i.
- Laruelle M, Abi-Dargham A, van Dyck C, Krystal J, Charney D, Innis R. 208. Increased striatal dopamine release in drug free schizophrenic subjects. Biological Psychiatry 1996, 39: 560. DOI: 10.1016/0006-3223(96)84153-9.
- Gil R, D’Souza D, Zuzarte E, Damon D, Genovese A, Boutros N, Abi-Dargham A, Innis R, Charney D, Krystal J. 326. GABA-serotonin interactions in healthy subjects: Implications for psychosis. Biological Psychiatry 1996, 39: 595-596. DOI: 10.1016/0006-3223(96)84271-5.
- Krystal J, Compere S, Nestler E, Rasmussen K. Nimodipine reduction of naltrexone-precipitated locus coeruleus activation and abstinence behavior in morphine-dependent rats. Physiology & Behavior 1996, 59: 863-866. PMID: 8778878, DOI: 10.1016/0031-9384(95)02206-6.
- Hillbrand M, Young J, Krystal J. Recurrent self-injurious behavior in forensic patients. Psychiatric Quarterly 1996, 67: 33-45. PMID: 8623037, DOI: 10.1007/bf02244273.
- D'Souza D, White J, Abi-Saab D, Damon D, Gil R, Zuzarte E, Krystal J. Dose response of oral D-cycloserine in unmedicated and medicated schizophrenics. Schizophrenia Research 1996, 18: 134. DOI: 10.1016/0920-9964(96)85447-8.
- Laruelle M, Abi-Dargham A, Gil R, van Dyck C, Erdos J, D'Souza D, Rosenblatt W, McCance-Katz E, Zea-Ponce Y, Zoghbi S, Baldwin R, Hoffer P, Krystal J, Charney D, Innis R. SPECT imaging of synaptic dopamine release in drug free schizophrenic patients: An experimental validation of the dopamine hypothesis of schizophrenia. Schizophrenia Research 1996, 18: 198-199. DOI: 10.1016/0920-9964(96)85619-2.
- Miller HL, Delgado PL, Salomon RM, Berman R, Krystal JH, Heninger GR, Charney DS. Clinical and Biochemical Effects of Catecholamine Depletion on Antidepressant-Induced Remission of Depression. JAMA Psychiatry 1996, 53: 117-128. PMID: 8629887, DOI: 10.1001/archpsyc.1996.01830020031005.
- Karper LP, Freeman GK, Grillon C, Morgan CA, Charney DS, Krystal JH. Preliminary evidence of an association between sensorimotor gating and distractibility in psychosis. Journal Of Neuropsychiatry 1996, 8: 60-66. PMID: 8845703, DOI: 10.1176/jnp.8.1.60.
- Krystal J, Bennett A, Bremner J, Southwick S, Charney D. Recent Developments in the Neurobiology of Dissociation. 1996, 163-190. DOI: 10.1007/978-1-4899-0310-5_8.
- Petrakis I, Satel S, Stine S, Kosten T, Namanworth S, Charney D, Krystal J. AMPT Effects on Cue-Induced Craving for Cocaine. American Journal On Addictions 1996, 5: 313-320. DOI: 10.3109/10550499608995682.
- Lam RW, Zis AP, Grewal A, Delgado PL, Charney DS, Krystal JH. Effects of Rapid Tryptophan Depletion in Patients With Seasonal Affective Disorder in Remission After Light Therapy. JAMA Psychiatry 1996, 53: 41-44. PMID: 8540776, DOI: 10.1001/archpsyc.1996.01830010043007.
- Krystal JH, Deutsch DN, Charney DS. The biological basis of panic disorder. The Journal Of Clinical Psychiatry 1996, 57 Suppl 10: 23-31; discussion 32-3. PMID: 8917129.
- Seibyl JP, Zea-Ponce Y, Brenner L, Baldwin RM, Krystal JH, Offord SJ, Mochoviak S, Charney DS, Hoffer PB, Innis RB. Continuous intravenous infusion of iodine-123-IBZM for SPECT determination of human brain dopamine receptor occupancy by antipsychotic agent RWJ-37796. Journal Of Nuclear Medicine 1996, 37: 11-5. PMID: 8543979.
- Krystal JH, Webb E, Cooney NL, Kranzler HR, Southwick SW, Heninger GR, Charney DS. Serotonergic and noradrenergic dysregulation in alcoholism: m- chlorophenylpiperazine and yohimbine effects in recently detoxified alcoholics and healthy comparison subjects. American Journal Of Psychiatry 1996, 153: 83-92. PMID: 8540598, DOI: 10.1176/ajp.153.1.83.
- Bremner J, Krystal J, Southwick S, Charney D. Functional neuroanatomical correlates of the effects of stress on memory. Journal Of Traumatic Stress 1995, 8: 527-553. DOI: 10.1007/bf02102888.
- Stine S, Krystal J, Kosten T, Charney D. Mazindol treatment for cocaine dependence. Drug And Alcohol Dependence 1995, 39: 245-252. PMID: 8556974, DOI: 10.1016/0376-8716(95)01174-4.
- Bremner J, Krystal J, Southwick S, Charney D. Functional neuroanatomical correlates of the effects of stress on memory. Journal Of Traumatic Stress 1995, 8: 527-553. PMID: 8564272, DOI: 10.1002/jts.2490080403.
- D'Souza D, Charney D, Krystal J. Glycine Site Agonists of the NMDA Receptor: A Review. CNS Neuroscience & Therapeutics 1995, 1: 227-260. DOI: 10.1111/j.1527-3458.1995.tb00285.x.
- Randall P, Bremner J, Krystal J, Nagy L, Heninger G, Nicolaou A, Charney D. Effects of the benzodiazepine antagonist flumazenil in PTSD. Biological Psychiatry 1995, 38: 319-324. PMID: 7495926, DOI: 10.1016/0006-3223(94)00306-n.
- Goddard A, Charney D, Germine M, Woods S, Heninger G, Krystal J, Goodman W, Price L. Effects of tryptophan depletion on responses to yohimbine in healthy human subjects. Biological Psychiatry 1995, 38: 74-85. PMID: 7578653, DOI: 10.1016/0006-3223(94)00223-p.
- Satel SL, Krystal JH, Delgado PL, Kosten TR, Charney DS. Tryptophan depletion and attenuation of cue-induced craving for cocaine. American Journal Of Psychiatry 1995, 152: 778-783. PMID: 7726319, DOI: 10.1176/ajp.152.5.778.
- Karper L, Grillon C, Abi-Saab D, Morgan C, Charney D, Krystal J. The effect of ketamine on pre-pulse inhibition and attention. Schizophrenia Research 1995, 15: 180. DOI: 10.1016/0920-9964(95)95554-m.
- Belger A, McCarthy G, Gore J, Puce A, Constable T, Krystal J. Evaluation of frontal and parietal association cortex contributions to attention using fMRI. Schizophrenia Research 1995, 15: 76. DOI: 10.1016/0920-9964(95)95239-6.
- Krystal J, Karper L, D'Souza C, Webb E, Bennett A, Abi-Dargham A, Petrakis I, Brenner L, Morrissey K, Abi-Saab D, Charney D. Differentiating nmda dysregulation in schizophrenia and alcoholism using ketamine. Schizophrenia Research 1995, 15: 156. DOI: 10.1016/0920-9964(95)95484-q.
- D'Souza D, Morrissey K, Abi-Saab D, Damon D, Gil R, Bennett A, Krystal J. Intravenous glycine and oral d-Cycloserine effects on CSF Amino acids, plasma hormones and behavior in healthy humans: Implications for schizophrenia. Schizophrenia Research 1995, 15: 147. DOI: 10.1016/0920-9964(95)95456-j.
- Bennett A, Abi-Saab D, Karper L, D'Souza D, Abi-Dargham A, Charney D, Krystal J. Ketamine impairs learning, but not procedural expression, on the wisconsin card sorting test. Schizophrenia Research 1995, 15: 108-109. DOI: 10.1016/0920-9964(95)95333-5.
- Krystal J, Karper L, Bennett A, Abi-Saab D, D'Souza C, Abi-Dargham A, Charney D. Modulating ketamine-induced thought disorder with lorazepam and haloperidol in humans. Schizophrenia Research 1995, 15: 156-157. DOI: 10.1016/0920-9964(95)95485-r.
- Abi-Dargham A, Krystal J, Laruelle M, D'Souza D, Zoghbi S, Brenner L, Gil R, Sernyak M, Baldwin R, Zubal G, Hoffer P, Charney D, Innis R. Spect imaging of the benzodiazepine receptor in schizophrenics and healthy subjects. Schizophrenia Research 1995, 15: 75. DOI: 10.1016/0920-9964(95)95236-3.
- McDougle C, Price L, Heninger G, Krystal J, Charney D. Noradrenergic response to acute ethanol administration in heathly subjects: comparison with intravenous yohimbine. Psychopharmacology 1995, 118: 127-135. PMID: 7617798, DOI: 10.1007/bf02245830.
- HILLBRAND M, YOUNG J, KRYSTAL J. Discontinuing Anticonvulsant Treatment of Aggression. Journal Of Neuropsychiatry 1995, 7: 116-a-117. PMID: 7711482, DOI: 10.1176/jnp.7.1.116-a.
- Morgan CA, Grillon C, Southwick SM, Nagy LM, Davis M, Krystal JH, Charney DS. Yohimbine facilitated acoustic startle in combat veterans with post-traumatic stress disorder. Psychopharmacology 1995, 117: 466-471. PMID: 7604149, DOI: 10.1007/bf02246220.
- Southwick S, Krystal J, Johnson D, Charney D. Neurobiology of Post-Traumatic Stress Disorder. Springer Series On Stress And Coping 1995, 49-72. DOI: 10.1007/978-1-4899-1034-9_4.
- Southwick S, Krystal J, Charney D. Relationship of Panic Disorder to Posttraumatic Stress Disorder-Reply. JAMA Psychiatry 1995, 52: 77-78. DOI: 10.1001/archpsyc.1995.03950130077012.
- Krystal J, Woods S, Kosten T, Rosen M, Seibyl J, Van Dyck C, Price L, Zubal I, Hoffer P, Charney D. Opiate Dependence and Withdrawal: Preliminary Assessment Using Single Photon Emission Computerized Tomography (SPECT). The American Journal Of Drug And Alcohol Abuse 1995, 21: 47-63. PMID: 7762544, DOI: 10.3109/00952999509095229.
- Karper L, Bennett A, Erdos J, Krystal J. ANTIPSYCHOTICS, LITHIUM, BENZODIAZEPINES, BETA-BLOCKERS. Journal Of Offender Rehabilitation 1994, 21: 203-222. DOI: 10.1300/j076v21n03_13.
- van Dyck C, Rosen M, Thomas H, McMahon T, Wallace E, O'Connor P, Sullivan M, Krystal J, Hoffer P, Woods S, Kosten T. SPECT regional cerebral blood flow alterations in naltrexone-precipitated withdrawal from buprenorphine. Psychiatry Research 1994, 55: 181-191. PMID: 7701033, DOI: 10.1016/0925-4927(94)90013-2.
- Salomon R, Delgado P, Licinio J, Krystal J, Heninger G, Charney D. Effects of sleep deprivation on serotonin function in depression. Biological Psychiatry 1994, 36: 840-846. PMID: 7893848, DOI: 10.1016/0006-3223(94)90595-9.
- Krystal JH, Webb E, Cooney N, Kranzler HR, Charney DS. Specificity of Ethanollike Effects Elicited by Serotonergic and Noradrenergic Mechanisms. JAMA Psychiatry 1994, 51: 898-911. PMID: 7944878, DOI: 10.1001/archpsyc.1994.03950110058008.
- D'SOUZA D, BENNETT A, ABI-DARGHAM A, KRYSTAL J. Precipitation of a Psychoneuromotor Syndrome by Fluoxetine in a Haloperidol-. Journal Of Clinical Psychopharmacology 1994, 14: 361-362. PMID: 7806697, DOI: 10.1097/00004714-199410000-00018.
- Brenner L, Karper L, Krystal J. Short-Term Use of Disulfiram With Clozapine. Journal Of Clinical Psychopharmacology 1994, 14: 213-214. PMID: 8027424, DOI: 10.1097/00004714-199406000-00016.
- Southwick S, Bremner D, Krystal J, Charney D. Psychobiologic Research in Post-Traumatic Stress Disorder. Psychiatric Clinics Of North America 1994, 17: 251-264. PMID: 7937357, DOI: 10.1016/s0193-953x(18)30112-6.
- D'Souza D, Bennett A, Karper L, Gil R, Morrissey K, Abi-Saab D, Charney D, Krystal J. I.V. glycine/d-cycloserine to facilitate NMDA function in humans. Biological Psychiatry 1994, 35: 734. DOI: 10.1016/0006-3223(94)91085-5.
- Krystal J, Southwick S, Charney D. Alcohol Dependence May Be the Missing Link Between Posttraumatic Stress Disorder and Panic-Reply. JAMA Psychiatry 1994, 51: 430-430. DOI: 10.1001/archpsyc.1994.03950050090014.
- Karper L, Grillon C, Lysaker P, Bell M, Charney D, Krystal J. Soft signs, attention, and startle in schizophrenia. Biological Psychiatry 1994, 35: 714. DOI: 10.1016/0006-3223(94)91014-6.
- D'Souza D, Gil R, Abi-Dargham A, Karper L, Abi-Saab D, Morrissey K, Brenner L, Charney D, Krystal J. Tryptophan depletion paradigm: Implications for schizophrenia. Biological Psychiatry 1994, 35: 703. DOI: 10.1016/0006-3223(94)90974-1.
- Krystal JH, Karper LP, Seibyl JP, Freeman GK, Delaney R, Bremner JD, Heninger GR, Bowers MB, Charney DS. Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans: Psychotomimetic, Perceptual, Cognitive, and Neuroendocrine Responses. JAMA Psychiatry 1994, 51: 199-214. PMID: 8122957, DOI: 10.1001/archpsyc.1994.03950030035004.
- D'Souza D, Krystal J. Perturbing the Organism: The Biology of Stressful Experience. The Journal Of Nervous And Mental Disease 1994, 182: 126. DOI: 10.1097/00005053-199402000-00023.
- DOCHERTY N, EVANS I, SLEDGE W, SEIBYL J, KRYSTAL J. Affective Reactivity of Language in Schizophrenia. The Journal Of Nervous And Mental Disease 1994, 182: 98-103. PMID: 8308539, DOI: 10.1097/00005053-199402000-00006.
- HILLBRAND M, KRYSTAL J, SHARPE K, FOSTER H. Clinical Predictors of Self-Mutilation in Hospitalized Forensic Patients. The Journal Of Nervous And Mental Disease 1994, 182: 9-16. PMID: 8277305, DOI: 10.1097/00005053-199401000-00003.
- Licinio J, Seibyl JP, Altemus M, Charney DS, Krystal JH. Elevated CSF levels of interleukin-2 in neuroleptic-free schizophrenic patients. American Journal Of Psychiatry 1993, 150: 1408-1410. PMID: 8102512, DOI: 10.1176/ajp.150.9.1408.
- Krystal JH, Seibyl JP, Price LH, Woods SW, Heninger GR, Aghajanian GK, Charney DS. m-Chlorophenylpiperazine Effects in Neuroleptic-Free Schizophrenic Patients: Evidence Implicating Serotonergic Systems in the Positive Symptoms of Schizophrenia. JAMA Psychiatry 1993, 50: 624-635. PMID: 8102048, DOI: 10.1001/archpsyc.1993.01820200034004.
- Karper L, Bell M, Lysaker P, Seibyl J, Beam-Goulet J, Brenner L, Krystal J. The neurological evaluation scale (NES): Factor analysis and clinical correlates. Schizophrenia Research 1993, 9: 179. DOI: 10.1016/0920-9964(93)90354-l.
- Abi-Dargham A, Seibyl J, Laruelle M, Rattner Z, Zoghbi S, Baldwin R, Ponce Y, Charney D, Hoffer P, Krystal J, Innis R. Spect imaging of the benzodiazepine receptor in humans using [123I]iomazenil. Schizophrenia Research 1993, 9: 191. DOI: 10.1016/0920-9964(93)90389-z.
- Karper L, Freeman G, Morgan C, Grillon C, Charney D, Krystal J. Pre-pulse inhibition of the acoustic startle response and measures of attention in schizophrenic subjects. Schizophrenia Research 1993, 9: 160. DOI: 10.1016/0920-9964(93)90296-u.
- Krystal J, Karper L, Seibyl J, Delaney R, Bremner J, Bowers M, Charney D. Dose-related effects of the NMDA antagonist, ketamine, in healthy humans. Schizophrenia Research 1993, 9: 240-241. DOI: 10.1016/0920-9964(93)90538-t.
- Krystal J, Karper L, Abi-Dargham A, Delaney R, Bremmer J, Bowers M, Charney D. Ketamine effects reduced by lorazepam in healthy humans. Schizophrenia Research 1993, 9: 241. DOI: 10.1016/0920-9964(93)90539-u.
- Charney DS, Deutch AY, Krystal JH, Southwick SM, Davis M. Psychobiologic Mechanisms of Posttraumatic Stress Disorder. JAMA Psychiatry 1993, 50: 294-305. PMID: 8466391, DOI: 10.1001/archpsyc.1993.01820160064008.
- Southwick SM, Krystal JH, Morgan CA, Johnson D, Nagy LM, Nicolaou A, Heninger GR, Charney DS. Abnormal Noradrenergic Function in Posttraumatic Stress Disorder. JAMA Psychiatry 1993, 50: 266-274. PMID: 8466387, DOI: 10.1001/archpsyc.1993.01820160036003.
- NAGY L, KRYSTAL J, CHARNEY D, MERIKANGAS K, WOODS S. Long-Term Outcome of Panic Disorder After Short-Term Imipramine and Behavioral Group Treatment. Journal Of Clinical Psychopharmacology 1993, 13: 16-24. PMID: 8098050, DOI: 10.1097/00004714-199302000-00003.
- Morgan CA, Southwick SM, Grillon C, Davis M, Krystal JH, Charney DS. Yohimbine — facilitated acoustic startle reflex in humans. Psychopharmacology 1993, 110: 342-346. PMID: 7831429, DOI: 10.1007/bf02251291.
- Krystal J. Stress, the Aging Brain, and the Mechanisms of Neuron Death. The Yale Journal Of Biology And Medicine 1993, 66: 109-110. PMCID: PMC2588844.
- SEIBYL J, SATEL S, ANTHONY D, SOUTHWICK S, KRYSTAL J, CHARNEY D. Effects of Cocaine on Hospital Course in Schizophrenia. The Journal Of Nervous And Mental Disease 1993, 181: 31-37. PMID: 8093475, DOI: 10.1097/00005053-199301000-00006.
- Yehuda R, Southwick SM, Krystal JH, Bremner D, Charney DS, Mason JW. Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder. American Journal Of Psychiatry 1993, 150: 83-86. PMID: 8417586, DOI: 10.1176/ajp.150.1.83.
- Karper LP, Salloway SP, Seibyl JP, Krystal JH. Prolonged postictal encephalopathy in two patients with clozapine- induced seizures. Journal Of Neuropsychiatry 1992, 4: 454-457. PMID: 1422175, DOI: 10.1176/jnp.4.4.454.
- Grillon C, Ameli R, Charney D, Krystal J, Braff D. Startle gating deficits occur across prepulse intensities in schizophrenic patients. Biological Psychiatry 1992, 32: 939-943. PMID: 1467378, DOI: 10.1016/0006-3223(92)90183-z.
- Kosten T, Krystal J, Giller E, Frank J, Dan E. Alexithymia as a predictor of treatment response in post-traumatic stress disorder. Journal Of Traumatic Stress 1992, 5: 563-573. DOI: 10.1007/bf00979225.
- Kosten T, Krystal J, Giller E, Frank J, Dan E. Alexithymia as a predictor of treatment response in post‐traumatic stress disorder. Journal Of Traumatic Stress 1992, 5: 563-573. DOI: 10.1002/jts.2490050406.
- Charney DS, Woods SW, Krystal JH, Nagy LM, Heninger GR. Noradrenergic neuronal dysregulation in panic disorder: the effects of intravenous yohimbine and clonidine in panic disorder patients. Acta Psychiatrica Scandinavica 1992, 86: 273-282. PMID: 1333719, DOI: 10.1111/j.1600-0447.1992.tb03266.x.
- Krystal J, McDougle C, Woods S, Price L, Heninger G, Charney D. Dose-response relationship for oral idazoxan effects in healthy human subjects: comparison with oral yohimbine. Psychopharmacology 1992, 108: 313-319. PMID: 1355923, DOI: 10.1007/bf02245117.
- Seibyl J, Brenner L, Krystal J, Johnson R, Charney D. Mazindol and cocaine addiction in schizophrenia. Biological Psychiatry 1992, 31: 1179-1181. PMID: 1525287, DOI: 10.1016/0006-3223(92)90171-u.
- KARPER L, SEIBYL J, KRYSTAL J. Valproate Management of Psychosis in a Patient with Carbamazepine-Induced Hyponatremia. Journal Of Clinical Psychopharmacology 1992, 12: 137-138. PMID: 1573038, DOI: 10.1097/00004714-199204000-00015.
- WOODS S, NAGY L, KOLESZAR A, KRYSTAL J, HENINGER G, CHAEY D. Controlled Trial of Alprazolam Supplementation During Imipramine Treatment of Panic Disorder. Current Opinion In Cardiology 1992, 7: 32. DOI: 10.1097/00001573-199202000-00006.
- WOODS S, NAGY L, KOLESZAR A, KRYSTAL J, HENINGER G, CHARNEY D. Controlled Trial of Alprazolam Supplementation During Imipramine Treatment of Panic Disorder. Journal Of Clinical Psychopharmacology 1992, 12: 32-38. PMID: 1552038, DOI: 10.1097/00004714-199202000-00006.
- Krystal J. Novel Antipsychotic Drugs. The Yale Journal Of Biology And Medicine 1992, 65: 539-540. PMCID: PMC2589751.
- Krystal J. Trauma and the Vietnam War Generation. The Yale Journal Of Biology And Medicine 1992, 65: 543-544. PMCID: PMC2589725.
- Krystal J, McDougle C, Kosten T, Price L, Aghajanian G, Charney D. Baclofen-assisted detoxification from opiates A pilot study. Journal Of Substance Use And Addiction Treatment 1992, 9: 139-142. PMID: 1324986, DOI: 10.1016/0740-5472(92)90081-x.
- Krystal J, Price L, Opsahl C, Ricaurte G, Heninger G. Chronic 3,4-Methylenedioxymethamphetamine (MDMA) Use: Effects on Mood and Neuropsychological Function? The American Journal Of Drug And Alcohol Abuse 1992, 18: 331-341. PMID: 1357957, DOI: 10.3109/00952999209026070.
- Krystal J. Invited commentary: complexities in evaluating neurobiological models for stress resistance. Journal Of Psychopharmacology 1992, 6: 12-14. PMID: 22291236, DOI: 10.1177/026988119200600105.
- Krystal JH, Leaf PJ, Bruce ML, Charney DS. Effects of age and alcoholism on the prevalence of panic disorder. Acta Psychiatrica Scandinavica 1992, 85: 77-82. PMID: 1546554, DOI: 10.1111/j.1600-0447.1992.tb01447.x.
- Rasmussen K, Krystal J, Aghajanian G. Excitatory amino acids and morphine withdrawal: differential effects of central and peripheral kynurenic acid administration. Psychopharmacology 1991, 105: 508-512. PMID: 1771218, DOI: 10.1007/bf02244371.
- Satel SL, Price LH, Palumbo JM, McDougle CJ, Krystal JH, Gawin F, Charney DS, Heninger GR, Kleber HD. Clinical phenomenology and neurobiology of cocaine abstinence: a prospective inpatient study. American Journal Of Psychiatry 1991, 148: 1712-1716. PMID: 1957935, DOI: 10.1176/ajp.148.12.1712.
- Krystal J, Woods S, Hill C, Charney D. Characteristics of panic attack subtypes: Assessment of spontaneous panic, situational panic, sleep panic, and limited symptom attacks. Comprehensive Psychiatry 1991, 32: 474-480. PMID: 1778074, DOI: 10.1016/0010-440x(91)90026-9.
- Gelernter J, O'Malley S, Risch N, Kranzler HR, Krystal J, Merikangas K, Kennedy JL, Kidd KK. NO Association Between an Allele at the D2 Dopamine Receptor Gene (DRD2) and Alcoholism. JAMA 1991, 266: 1801-1807. PMID: 1832467, DOI: 10.1001/jama.1991.03470130081033.
- Nagy L, Krystal J, Charney D, Woods S. Follow-up Study of Patients With Panic Disorder-Reply. JAMA Psychiatry 1991, 48: 861-862. DOI: 10.1001/archpsyc.1991.01810330085018.
- Seibyl J, Krystal J, Price L, Woods S, D'Amico C, Heninger G, Charney D. Effects of ritanserin on the behavioral, neuroendocrine, and cardiovascular responses to meta-chlorophenylpiperazine in healthy human subjects. Psychiatry Research 1991, 38: 227-236. PMID: 1754635, DOI: 10.1016/0165-1781(91)90013-f.
- Licinio J, Krystal J, Seibyl J, Altemus M, Charney D. Elevated central levels of interleukin-2 in drug-free schizophrenic patients. Schizophrenia Research 1991, 4: 372. DOI: 10.1016/0920-9964(91)90301-7.
- Krystal J, Seibyl J, Price L, Woods S, Heninger G, Charney D. MCPP effects in schizophrenic patients before and after typical and atypical neuroleptic treatment. Schizophrenia Research 1991, 4: 350. DOI: 10.1016/0920-9964(91)90266-t.
- Deutch A, Moghaddam B, Innis R, Krystal J, Aghajanian G, Bunney B, Charney D. Mechanisms of action of atypical antipsychotic drugs Implications for novel therapeutic strategies for schizophrenia. Schizophrenia Research 1991, 4: 121-156. PMID: 1674882, DOI: 10.1016/0920-9964(91)90030-u.
- Woods S, Charney D, Silver J, Krystal J, Heninger G. Behavioral, biochemical, and cardiovascular responses to the benzodiazepine receptor antagonist flumazenil in panic disorder. Psychiatry Research 1991, 36: 115-127. PMID: 1850142, DOI: 10.1016/0165-1781(91)90124-8.
- Woods SW, Hegeman IM, Zubal IG, Krystal JH, Koster K, Smith EO, Heninger GR, Hoffer PB. Visual stimulation increases technetium-99m-HMPAO distribution in human visual cortex. Journal Of Nuclear Medicine 1991, 32: 210-5. PMID: 1992020.
- Woods S, O'malley S, Martini B, Mcdougle C, Price L, Krystal J, Hoffer P, Kosten T. Spect regional cerebral blood flow and neuropsychological testing in non-demented HIV-positive drug abusers: Preliminary results. Progress In Neuro-Psychopharmacology And Biological Psychiatry 1991, 15: 649-662. PMID: 1956993, DOI: 10.1016/0278-5846(91)90055-6.
- Delgado PL, Price LH, Miller HL, Salomon RM, Licinio J, Krystal JH, Heninger GR, Charney DS. Rapid serotonin depletion as a provocative challenge test for patients with major depression: relevance to antidepressant action and the neurobiology of depression. Psychopharmacology Bulletin 1991, 27: 321-30. PMID: 1775606.
- Charney DS, Woods SW, Nagy LM, Southwick SM, Krystal JH, Heninger GR. Noradrenergic function in panic disorder. The Journal Of Clinical Psychiatry 1990, 51 Suppl A: 5-11. PMID: 2258377.
- CHARNEY D, WOODS S, KRYSTAL J, HENINGER G. Serotonin Function and Human Anxiety Disordersa. Annals Of The New York Academy Of Sciences 1990, 600: 558-572. PMID: 2252335, DOI: 10.1111/j.1749-6632.1990.tb16910.x.
- Charney D, Krystal J, Southwick S, Nagy L, Woods S, Heninger G. Serotonin Function in Panic and Generalized Anxiety Disorders. Psychiatric Annals 1990, 20: 593-602. DOI: 10.3928/0048-5713-19901001-11.
- Rasmussen K, Beitner-Johnson D, Krystal J, Aghajanian G, Nestler E. Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates. Journal Of Neuroscience 1990, 10: 2308-2317. PMID: 2115910, PMCID: PMC6570391, DOI: 10.1523/jneurosci.10-07-02308.1990.
- Goodman WK, Price LH, Delgado PL, Palumbo J, Krystal JH, Nagy LM, Rasmussen SA, Heninger GR, Charney DS. Specificity of Serotonin Reuptake Inhibitors in the Treatment of Obsessive-Compulsive Disorder: Comparison of Fluvoxamine and Desipramine. JAMA Psychiatry 1990, 47: 577-585. PMID: 2112374, DOI: 10.1001/archpsyc.1990.01810180077011.
- Charney D, Woods S, Krystal J, Heninger G. Neurobiological Mechanisms of Human Anxiety. Progress In Basic And Clinical Pharmacology 1990, 3: 242-283. DOI: 10.1159/000417680.
- McDougle CJ, Goodman WK, Price LH, Delgado PL, Krystal JH, Charney DS, Heninger GR. Neuroleptic addition in fluvoxamine-refractory obsessive-compulsive disorder. American Journal Of Psychiatry 1990, 147: 652-654. PMID: 1970224, DOI: 10.1176/ajp.147.5.652.
- Price LH, Charney DS, Delgado PL, Goodman WK, Krystal JH, Woods SW, Heninger GR. Clinical data on the role of serotonin in the mechanism(s) of action of antidepressant drugs. The Journal Of Clinical Psychiatry 1990, 51 Suppl: 44-50; discussion 51-2. PMID: 2182616.
- Price L, Krystal J, Heninger G, Ricaurte G. Second Thoughts on 3,4-Methylenedioxymethamphetamine (MDMA) Neurotoxicity-Reply. JAMA Psychiatry 1990, 47: 289-289. DOI: 10.1001/archpsyc.1990.01810150089015.
- Kosten T, Krystal J, Charney D, Price L, Morgan C, Kleber H. Opioid antagonist challenges in buprenorphine maintained patients. Drug And Alcohol Dependence 1990, 25: 73-78. PMID: 2323312, DOI: 10.1016/0376-8716(90)90144-4.
- SEIBYL J, KRYSTAL J, CHARNEY D. Marijuana (cannabis) use is anecdotally said to precipitate anxiety symptoms in patients with panic disorder. Is there any research evidence to support this? Also, can marijuana use precipitate or expose paranoia in patients with an underlying bipolar disorder? Journal Of Clinical Psychopharmacology 1990, 10: 78. PMID: 2307743, DOI: 10.1097/00004714-199002000-00033.
- Charney DS, Krystal JH, Delgado PL, Heninger GR. Serotonin-Specific Drugs for Anxiety and Depressive Disorders. Annual Review Of Medicine 1990, 41: 437-446. PMID: 2139556, DOI: 10.1146/annurev.me.41.020190.002253.
- Price L, Charney D, Delgado P, Goodman W, Krystal J, Woods S, Heninger G. Clinical studies of 5-HT function using I.V. l-Tryptophan. Progress In Neuro-Psychopharmacology And Biological Psychiatry 1990, 14: 459-472. PMID: 2236580, DOI: 10.1016/0278-5846(90)90002-x.
- Nagy LM, Krystal JH, Woods SW, Charney DS. Clinical and Medication Outcome After Short-term Alprazolam and Behavorial Group Treatment in Panic Disorder: 2.5-Year Naturalistic Follow-up Study. JAMA Psychiatry 1989, 46: 993-999. PMID: 2818144, DOI: 10.1001/archpsyc.1989.01810110035005.
- Kosten TR, Krystal JH, Charney DS, Price LH, Morgan CH, Kleber HD. Rapid detoxification from opioid dependence. American Journal Of Psychiatry 1989, 146: 1349a-1349. PMID: 2675644, DOI: 10.1176/ajp.146.10.1349a.
- Woods S, Hegeman I, Krystal J, Smith E, Zubal I, Koster K, Hotfer P. EFFECTS OF VISUAL STIMULATION ON DISTRIBUTION OF TC-99M D, 1 HMPAO IN HEALTHY HUMAN SUBJECTS. Clinical Nuclear Medicine 1989, 14: 230. DOI: 10.1097/00003072-198903000-00025.
- Koster K, Woods S, Smith E, Zubal I, Krystal J, Charney D, Hoffer P. REGIONAL CEREBRAL BLOOD FLOW CHANGES IN PATIENTS WITH PANIC DISORDER. Clinical Nuclear Medicine 1989, 14: 234. DOI: 10.1097/00003072-198903000-00039.
- Krystal J, Walker M, Heninger G. Intermittent naloxone attenuates the development of physical dependence on methadone in rhesus monkeys. European Journal Of Pharmacology 1989, 160: 331-338. PMID: 2540995, DOI: 10.1016/0014-2999(89)90088-5.
- SEIBYL J, KRYSTAL J, PRICE L, CHARNEY D. Use of Yohimbine to Counteract Nortriptyline-Induced Orthostatic Hypotension. Journal Of Clinical Psychopharmacology 1989, 9: 67-68. PMID: 2708559, DOI: 10.1097/00004714-198902000-00026.
- Krystal J, Kosten T, Southwick S, Mason J, Perry B, Giller E. Neurobiological aspects of PTSD: Review of clinical and preclinical studies. Behavior Therapy 1989, 20: 177-198. DOI: 10.1016/s0005-7894(89)80068-1.
- Krystal J. Psychopharmacology: The Third Generation of Progress. The Yale Journal Of Biology And Medicine 1989, 62: 554-555. PMCID: PMC2589180.
- Woods S, Krystal J, Heninger G, Charney D. Effects of alprazolam and clonidine on carbon dioxide-induced increases in anxiety ratings in healthy human subjects. Life Sciences 1989, 45: 233-242. PMID: 2503670, DOI: 10.1016/0024-3205(89)90255-5.
- Krystal J, Woods S, Levesque M, Heninger C, Heninger G. The effects of carbon dioxide inhalation of plasma MHPG, plasma hormones respiratory rate, and behavior in the Rhesus monkey. Life Sciences 1989, 45: 1657-1663. PMID: 2511388, DOI: 10.1016/0024-3205(89)90275-0.
- Price LH, Ricaurte GA, Krystal JH, Heninger GR. Responses to i.v. L-tryptophan in MDMA users. NIDA Research Monograph 1989, 95: 421-2. PMID: 2577044.
- Price LH, Ricaurte GA, Krystal JH, Heninger GR. Neuroendocrine and Mood Responses to Intravenous L-Tryptophan in 3,4-Methylenedioxymethamphetamine (MDMA) Users: Preliminary Observations. JAMA Psychiatry 1989, 46: 20-22. PMID: 2562914, DOI: 10.1001/archpsyc.1989.01810010022003.
- Woods SW, Koster K, Krystal JK, Smith EO, Zubal IG, Hoffer PB, Charney DS. YOHIMBINE ALTERS REGIONAL CEREBRAL BLOOD FLOW IN PANIC DISORDER. The Lancet 1988, 332: 678. PMID: 2901529, DOI: 10.1016/s0140-6736(88)90484-9.
- Krystal J. Neural Plasticity. A Lifespan Approach. The Yale Journal Of Biology And Medicine 1988, 61: 478-479. PMCID: PMC2590436.
- Woods SW, Krystal JH, D'Amico CL, Heninger GR, Charney DS. A review of behavioral and pharmacologic studies relevant to the application of CO2 as a human subject model of anxiety. Psychopharmacology Bulletin 1988, 24: 149-53. PMID: 3133718.
- Kosten T, Krystal J. Biological Mechanisms in Posttraumatic Stress Disorder Relevance for Substance Abuse. Recent Developments In Alcoholism 1988, 6: 49-68. PMID: 3283864, DOI: 10.1007/978-1-4615-7718-8_3.
- Krystal J. Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and Heart. The Yale Journal Of Biology And Medicine 1987, 60: 202-202. PMCID: PMC2590308.
- Krystal J. Quantitative Receptor Autoradiography. The Yale Journal Of Biology And Medicine 1987, 60: 294-295. PMCID: PMC2590106.
- Krystal J. The Psychopharmacology of Lithium. The Yale Journal Of Biology And Medicine 1986, 59: 74-75. PMCID: PMC2590046.
- Krystal H. Management of alcohol withdrawal in the critically ill patient: a selected review. Henry Ford Hospital Medical Journal 1986, 34: 293. PMID: 3583798.
- Krystal JH, Giller EL, Cicchetti DV. Assessment of alexithymia in posttraumatic stress disorder and somatic illness: introduction of a reliable measure. Psychosomatic Medicine 1986, 48: 84-94. PMID: 3945719, DOI: 10.1097/00006842-198601000-00007.
- van der Kolk B, Greenberg M, Boyd H, Krystal J. Inescapable shock, neurotransmitters, and addiction to trauma: Toward a psychobiology of post traumatic stress. Biological Psychiatry 1985, 20: 314-325. PMID: 2858226, DOI: 10.1016/0006-3223(85)90061-7.
- Krystal J. Behavioral Pharmacology: The Current Status. The Yale Journal Of Biology And Medicine 1985, 58: 197-198. PMCID: PMC2589892.
- Krystal J. Monoamine Innervation of the Cerebral Cortex. The Yale Journal Of Biology And Medicine 1985, 58: 58-59. PMCID: PMC2589842.
- Redmond DE, Krystal JH. Multiple Mechanisms of withdrawal from Opioid Drugs. Annual Review Of Neuroscience 1984, 7: 443-478. PMID: 6324646, DOI: 10.1146/annurev.ne.07.030184.002303.
- Krystal J. Physiology of Adrenocortical Secretion. Frontiers of Hormone Research. Volume 11. The Yale Journal Of Biology And Medicine 1984, 57: 247-247. PMCID: PMC2589820.
- Krystal J. Anorexia Nervosa: Recent Developments in Research. The Yale Journal Of Biology And Medicine 1984, 57: 442-443. PMCID: PMC2589855.
- Krystal J. Ethopharmacology: Primate Models of Neuropsychiatric Disorders. The Yale Journal Of Biology And Medicine 1984, 57: 248-250. PMCID: PMC2589821.
- Fassler D, Krystal J. The role of medical student societies in psychiatric recruitment. American Journal Of Psychiatry 1983, 140: 654a-654. PMID: 6846610, DOI: 10.1176/ajp.140.5.654a.
- Krystal JH, Redmond DE. A preliminary description of acute physical dependence on morphine in the vervet monkey. Pharmacology Biochemistry And Behavior 1983, 18: 289-291. PMID: 6682230, DOI: 10.1016/0091-3057(83)90379-9.
- Krystal J. The Natural History of Alcoholism: Causes, Patterns, and Paths to Recovery. The Yale Journal Of Biology And Medicine 1983, 56: 339-340. PMCID: PMC2589638.
- Krystal J, Arnold R. Psychopharmacology of Clonidine. The Yale Journal Of Biology And Medicine 1982, 55: 543-544. PMCID: PMC2596571.
- Krystal H. Trauma: considerations of its intensity and chronicity. International Psychiatry Clinics 1971, 8: 11-28. PMID: 5148247.
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