John Krystal, MD
Psychiatry, Addiction Medicine
Biography
John Krystal, MD, is a leading expert in the areas of alcoholism, post-traumatic stress disorder, schizophrenia, and depression. His work links psychopharmacology, neuroimaging, molecular genetics, and computational neuroscience to study the neurobiology and treatment of these disorders. He is best known for leading the discovery of the rapid antidepressant effects of ketamine in depressed patients.
He is a member of the U.S. National Academy of Medicine. He also serves in a variety of advisory and review capacities for NIAAA, NIMH, Wellcome Trust, Brain and Behavior Research Foundation, the Broad Institute, and the Karolinska Institutet.
Dr. Krystal previously served on the National Alcohol Abuse and Alcoholism Advisory Council (NIAAA), the Department of Defense Psychological Health Advisory Committee, and the NIMH Board of Scientific Counselors (chair, 2005-2007). He has led the American College of Neuropsychopharmacology (president, 2012), and International College of Neuropsychophamacology (president, 2016-2018).
Currently, he is co-chair of the Neuroscience Forum (NeuroForum) of the National Academies of Sciences, Engineering, and Medicine, a member of the NIMH National Mental Health Advisory Council, and he edits the journal, Biological Psychiatry (impact factor: 11.982).
Titles
- Robert L. McNeil, Jr. Professor of Translational Research and Professor of Psychiatry, of Neuroscience, and of Psychology
- Co-Director, Yale Center for Clinical Investigation
- Chair, Psychiatry
- Physician-in-Chief of Psychiatry, Yale New Haven Hospital
- Director: NIAAA Center for the Translational Neuroscience of Alcoholism
- Director, Clinical Neuroscience Division, VA National Center for PTSD
Education & Training
- ResidencyYale University School of Medicine (1988)
- MDYale University (1984)
- BAUniversity of Chicago, Behavioral Sciences (1980)
Additional Information
Honors & Recognitions
- Colvin Prize for Outstanding Achievement in Mood Disorders Research: Brain and Behavior Research Foundation (2019)
- Ulf van Euler Memorial Lecturer: Karolinska Institute (2019)
- Edward H. Ahrens, Jr., Distinguished Investigator Award: Association for Clinical and Translational Science (2019)
- E.M. Jellinek Award for Alcohol Research: E.M. Jellinek Foundation (2016)
- Henri Begleiter Award for Research Excellence: Research Society on Alcoholism (2015)
- Paul Hoch Research Award: American Psychopathological Association (2014)
- Exemplary Psychiatrist Award: National Alliance on Mental Illness (2011)
- Member: U.S. National Academy of Medicine (2010)
- Jack Mendelson Award for Clinical Research: National Institute on Alcohol Abuse and Alcoholism (2010)
- Stanley Dean Award for Schizophrenia Research: American College of Psychiatry (2010)
Board Certifications
- AB of Psychiatry & Neurology, Psychiatry (1991)
Professional Service
- Neuroscience Forum, National Academies of Sciences, Engineering, and Medicine (2018 - Present): Co-Director
- International College of Neuropsychopharmacology (2016 - 2018): President
- NIMH (2016 - Present): NIMH National Mental Health Advisory Council
- American College of Neuropsychopharmacology (2011 - 2012): President
Publications
- Kraguljac N, Bruns D, Appelbaum P, Botello E, King V, Remiszewski N, Widge A, Alpert J, Carpenter L, Grzenda A, Krystal J, McDonald W, Nemeroff C. Post-Roe v Wade psychiatry: legal, clinical, and ethical challenges in psychiatry under abortion bans. The Lancet Psychiatry 2024 PMID: 38795722, DOI: 10.1016/s2215-0366(24)00096-8.
- Martinez-Magaña J, Nagamatsu S, Nunez-Rios D, Krystal J, Girgenti M, Group T, Montalvo-Ortiz J. The Prefrontal Cortex Transcriptomic Landscape of the Comorbidity Between Post-Traumatic Stress Disorder and Opioid Misuse. Biological Psychiatry 2024, 95: s69. DOI: 10.1016/j.biopsych.2024.02.169.
- Nunez-Rios D, Hurd Y, Rompala G, Nagamatsu S, Martinez-Magaña J, Krystal J, Group T, Montalvo-Ortiz J. Multi-Omics Mapping in Human Cortical Neurons Reveals Well-Known and Novel Loci of Post-Traumatic Stress Disorder. Biological Psychiatry 2024, 95: s34. DOI: 10.1016/j.biopsych.2024.02.087.
- Lee K, Ji J, Fonteneau C, Berkovitch L, Rahmati M, Pan L, Repovš G, Krystal J, Murray J, Anticevic A. Human Brain State Dynamics Reflect Individual Neuro-Phenotypes. Biological Psychiatry 2024, 95: s53. DOI: 10.1016/j.biopsych.2024.02.133.
- Moujaes F, Ji J, Rahmati M, Burt J, Schleifer C, Adkinson B, Savic A, Santamauro N, Tamayo Z, Diehl C, Kolobaric A, Flynn M, Rieser N, Fonteneau C, Camarro T, Xu J, Cho Y, Repovs G, Fineberg S, Morgan P, Seifritz E, Vollenweider F, Krystal J, Murray J, Preller K, Anticevic A. Ketamine induces multiple individually distinct whole-brain functional connectivity signatures. ELife 2024, 13: e84173. PMID: 38629811, PMCID: PMC11023699, DOI: 10.7554/elife.84173.
- Na P, Petrakis I, Krystal J, Pietrzak R. Problem Opioid Use Among US Military Veterans: Prevalence, Correlates, and Psychiatric Characteristics. Journal Of Addiction Medicine 2024 PMID: 38498625, DOI: 10.1097/adm.0000000000001286.
- Havlik J, Wahid S, Teopiz K, McIntyre R, Krystal J, Rhee T. Recent Advances in the Treatment of Treatment-Resistant Depression: A Narrative Review of Literature Published from 2018 to 2023. Current Psychiatry Reports 2024, 26: 176-213. PMID: 38386251, DOI: 10.1007/s11920-024-01494-4.
- Basu A, Yang J, Yu A, Glaeser-Khan S, Rondeau J, Feng J, Krystal J, Li Y, Kaye A. Frontal norepinephrine represents a threat prediction error under uncertainty. Biological Psychiatry 2024 PMID: 38316333, DOI: 10.1016/j.biopsych.2024.01.025.
- Chekroud A, Hawrilenko M, Loho H, Bondar J, Gueorguieva R, Hasan A, Kambeitz J, Corlett P, Koutsouleris N, Krumholz H, Krystal J, Paulus M. Illusory generalizability of clinical prediction models. Science 2024, 383: 164-167. PMID: 38207039, DOI: 10.1126/science.adg8538.
- Huggins A, Baird C, Briggs M, Laskowitz S, Hussain A, Fouda S, Haswell C, Sun D, Salminen L, Jahanshad N, Thomopoulos S, Veltman D, Frijling J, Olff M, van Zuiden M, Koch S, Nawjin L, Wang L, Zhu Y, Li G, Stein D, Ipser J, Seedat S, du Plessis S, van den Heuvel L, Suarez-Jimenez B, Zhu X, Kim Y, He X, Zilcha-Mano S, Lazarov A, Neria Y, Stevens J, Ressler K, Jovanovic T, van Rooij S, Fani N, Hudson A, Mueller S, Sierk A, Manthey A, Walter H, Daniels J, Schmahl C, Herzog J, Říha P, Rektor I, Lebois L, Kaufman M, Olson E, Baker J, Rosso I, King A, Liberzon I, Angstadt M, Davenport N, Sponheim S, Disner S, Straube T, Hofmann D, Qi R, Lu G, Baugh L, Forster G, Simons R, Simons J, Magnotta V, Fercho K, Maron-Katz A, Etkin A, Cotton A, O’Leary E, Xie H, Wang X, Quidé Y, El-Hage W, Lissek S, Berg H, Bruce S, Cisler J, Ross M, Herringa R, Grupe D, Nitschke J, Davidson R, Larson C, deRoon-Cassini T, Tomas C, Fitzgerald J, Blackford J, Olatunji B, Kremen W, Lyons M, Franz C, Gordon E, May G, Nelson S, Abdallah C, Levy I, Harpaz-Rotem I, Krystal J, Dennis E, Tate D, Cifu D, Walker W, Wilde E, Harding I, Kerestes R, Thompson P, Morey R. Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup. Molecular Psychiatry 2024, 1-13. PMID: 38195980, DOI: 10.1038/s41380-023-02352-0.
- Tamman A, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal J, Gelernter J, Montalvo-Ortiz J, Polimanti R, Pietrzak R. Correction: Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Neuropsychopharmacology 2024, 49: 764-764. PMID: 38182778, PMCID: PMC10876612, DOI: 10.1038/s41386-023-01786-y.
- Krystal J, Imeh I, Garces R, Addy N. The Biological Psychiatry Cover Art Initiative: Addressing the Underrepresentation of Black People on the Journal Cover Through a Series of Commissioned Artworks. Biological Psychiatry 2024, 95: 2. PMID: 38030306, DOI: 10.1016/j.biopsych.2023.10.010.
- Zhou H, Kember R, Deak J, Xu H, Toikumo S, Yuan K, Lind P, Farajzadeh L, Wang L, Hatoum A, Johnson J, Lee H, Mallard T, Xu J, Johnston K, Johnson E, Nielsen T, Galimberti M, Dao C, Levey D, Overstreet C, Byrne E, Gillespie N, Gordon S, Hickie I, Whitfield J, Xu K, Zhao H, Huckins L, Davis L, Sanchez-Roige S, Madden P, Heath A, Medland S, Martin N, Ge T, Smoller J, Hougaard D, Børglum A, Demontis D, Krystal J, Gaziano J, Edenberg H, Agrawal A, Justice A, Stein M, Kranzler H, Gelernter J. Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals. Nature Medicine 2023, 29: 3184-3192. PMID: 38062264, PMCID: PMC10719093, DOI: 10.1038/s41591-023-02653-5.
- Perl O, Duek O, Kulkarni K, Gordon C, Krystal J, Levy I, Harpaz-Rotem I, Schiller D. Neural patterns differentiate traumatic from sad autobiographical memories in PTSD. Nature Neuroscience 2023, 26: 2226-2236. PMID: 38036701, DOI: 10.1038/s41593-023-01483-5.
- Yang J, Huggins A, Sun D, Baird C, Haswell C, Frijling J, Olff M, van Zuiden M, Koch S, Nawijn L, Veltman D, Suarez-Jimenez B, Zhu X, Neria Y, Hudson A, Mueller S, Baker J, Lebois L, Kaufman M, Qi R, Lu G, Říha P, Rektor I, Dennis E, Ching C, Thomopoulos S, Salminen L, Jahanshad N, Thompson P, Stein D, Koopowitz S, Ipser J, Seedat S, du Plessis S, van den Heuvel L, Wang L, Zhu Y, Li G, Sierk A, Manthey A, Walter H, Daniels J, Schmahl C, Herzog J, Liberzon I, King A, Angstadt M, Davenport N, Sponheim S, Disner S, Straube T, Hofmann D, Grupe D, Nitschke J, Davidson R, Larson C, deRoon-Cassini T, Blackford J, Olatunji B, Gordon E, May G, Nelson S, Abdallah C, Levy I, Harpaz-Rotem I, Krystal J, Morey R, Sotiras A. Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods. Neuropsychopharmacology 2023, 49: 609-619. PMID: 38017161, PMCID: PMC10789873, DOI: 10.1038/s41386-023-01763-5.
- Krystal J, Kaye A, Jefferson S, Girgenti M, Wilkinson S, Sanacora G, Esterlis I. Ketamine and the neurobiology of depression: Toward next-generation rapid-acting antidepressant treatments. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2305772120. PMID: 38011560, PMCID: PMC10710048, DOI: 10.1073/pnas.2305772120.
- Ward E, Fragala M, Birse C, Hawrilenko M, Smolka C, Ambwani G, Brown M, Krystal J, Corlett P, Chekroud A. Assessing the impact of a comprehensive mental health program on frontline health service workers. PLOS ONE 2023, 18: e0294414. PMID: 37988363, PMCID: PMC10662717, DOI: 10.1371/journal.pone.0294414.
- Zhu X, Kim Y, Ravid O, He X, Suarez-Jimenez B, Zilcha-Mano S, Lazarov A, Lee S, Abdallah C, Angstadt M, Averill C, Baird C, Baugh L, Blackford J, Bomyea J, Bruce S, Bryant R, Cao Z, Choi K, Cisler J, Cotton A, Daniels J, Davenport N, Davidson R, DeBellis M, Dennis E, Densmore M, deRoon-Cassini T, Disner S, Hage W, Etkin A, Fani N, Fercho K, Fitzgerald J, Forster G, Frijling J, Geuze E, Gonenc A, Gordon E, Gruber S, Grupe D, Guenette J, Haswell C, Herringa R, Herzog J, Hofmann D, Hosseini B, Hudson A, Huggins A, Ipser J, Jahanshad N, Jia-Richards M, Jovanovic T, Kaufman M, Kennis M, King A, Kinzel P, Koch S, Koerte I, Koopowitz S, Korgaonkar M, Krystal J, Lanius R, Larson C, Lebois L, Li G, Liberzon I, Lu G, Luo Y, Magnotta V, Manthey A, Maron-Katz A, May G, McLaughlin K, Mueller S, Nawijn L, Nelson S, Neufeld R, Nitschke J, O'Leary E, Olatunji B, Olff M, Peverill M, Phan K, Qi R, Quidé Y, Rektor I, Ressler K, Riha P, Ross M, Rosso I, Salminen L, Sambrook K, Schmahl C, Shenton M, Sheridan M, Shih C, Sicorello M, Sierk A, Simmons A, Simons R, Simons J, Sponheim S, Stein M, Stein D, Stevens J, Straube T, Sun D, Théberge J, Thompson P, Thomopoulos S, van der Wee N, van der Werff S, van Erp T, van Rooij S, van Zuiden M, Varkevisser T, Veltman D, Vermeiren R, Walter H, Wang L, Wang X, Weis C, Winternitz S, Xie H, Zhu Y, Wall M, Neria Y, Morey R. Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium. NeuroImage 2023, 283: 120412. PMID: 37858907, PMCID: PMC10842116, DOI: 10.1016/j.neuroimage.2023.120412.
- Tamman A, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal J, Gelernter J, Montalvo-Ortiz J, Polimanti R, Pietrzak R. Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Neuropsychopharmacology 2023, 49: 699-708. PMID: 37848731, PMCID: PMC10876568, DOI: 10.1038/s41386-023-01747-5.
- Krystal J, Preller K, Corlett P, Anticevic A, Kaye A. Psychedelics and the Neurobiology of Meaningfulness. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 9: 462-463. PMID: 37730161, DOI: 10.1016/j.bpsc.2023.09.003.
- Na P, Zhou H, Montalvo-Ortiz J, Cabrera-Mendoza B, Petrakis I, Krystal J, Polimanti R, Gelernter J, Pietrzak R. Positive personality traits moderate persistent high alcohol consumption, determined by polygenic risk in U.S. military veterans: results from a 10-year, population-based, observational cohort study. Psychological Medicine 2023, 53: 7893-7901. PMID: 37642191, DOI: 10.1017/s003329172300199x.
- Rompala G, Nagamatsu S, Martínez-Magaña J, Nuñez-Ríos D, Wang J, Girgenti M, Krystal J, Gelernter J, Hurd Y, Montalvo-Ortiz J. Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex. Nature Communications 2023, 14: 4544. PMID: 37507366, PMCID: PMC10382503, DOI: 10.1038/s41467-023-40285-y.
- Krystal J, Kavalali E, Monteggia L. Ketamine and rapid antidepressant action: new treatments and novel synaptic signaling mechanisms. Neuropsychopharmacology 2023, 49: 41-50. PMID: 37488280, PMCID: PMC10700627, DOI: 10.1038/s41386-023-01629-w.
- Benfer N, Grunthal B, Dondanville K, Young-McCaughan S, Blankenship A, Abdallah C, Back S, Flanagan J, Foa E, Fox P, Krystal J, Marx B, McGeary D, McLean C, Pruiksma K, Resick P, Roache J, Shiroma P, Sloan D, Taylor D, Wachen J, López-Roca A, Nicholson K, Schobitz R, Schrader C, Sharrieff A, Yarvis J, Mintz J, Keane T, Peterson A, Litz B. DSM-5 Criterion-A-Based Trauma Types in Service Members and Veterans Seeking Treatment for Posttraumatic Stress Disorder. Psychological Trauma Theory Research Practice And Policy 2023 PMID: 37410416, PMCID: PMC10770283, DOI: 10.1037/tra0001537.
- Duek O, Korem N, Li Y, Kelmendi B, Amen S, Gordon C, Milne M, Krystal J, Levy I, Harpaz-Rotem I. Long term structural and functional neural changes following a single infusion of Ketamine in PTSD. Neuropsychopharmacology 2023, 48: 1648-1658. PMID: 37270621, PMCID: PMC10517133, DOI: 10.1038/s41386-023-01606-3.
- Fischer I, Nichter B, Na P, Norman S, Krystal J, Pietrzak R. Longitudinal Trends in Suicidal Thoughts and Behaviors Among US Military Veterans During the COVID-19 Pandemic. JAMA Psychiatry 2023, 80: 577-584. PMID: 37017978, PMCID: PMC10077136, DOI: 10.1001/jamapsychiatry.2023.0393.
- Kaye A, Rao M, Kwan A, Ressler K, Krystal J. A computational model for learning from repeated traumatic experiences under uncertainty. Cognitive, Affective, & Behavioral Neuroscience 2023, 23: 894-904. PMID: 37165181, DOI: 10.3758/s13415-023-01085-5.
- Abi-Dargham A, Moeller S, Ali F, DeLorenzo C, Domschke K, Horga G, Jutla A, Kotov R, Paulus M, Rubio J, Sanacora G, Veenstra-VanderWeele J, Krystal J. Candidate biomarkers in psychiatric disorders: state of the field. World Psychiatry 2023, 22: 236-262. PMID: 37159365, PMCID: PMC10168176, DOI: 10.1002/wps.21078.
- Surti T, Ranganathan M, Johannesen J, Gueorguieva R, Deaso E, Kenney J, Krystal J, D'Souza D. Randomized controlled trial of the glycine transporter 1 inhibitor PF-03463275 to enhance cognitive training and neuroplasticity in schizophrenia. Schizophrenia Research 2023, 256: 36-43. PMID: 37141764, PMCID: PMC10257994, DOI: 10.1016/j.schres.2023.04.010.
- Sarantopoulos C, Shin D, Schleifer C, Moujaes F, Adkinson B, Ji J, Kolabaric A, Flynn M, Santamauro N, Krystal J, Murray J, Repovs G, Martin W, Pittenger C, Anticevic A, Cho Y. 511. Common and Distinct Effects of Incentives on Spatial Working Memory in Schizophrenia and Obsessive-Compulsive Disorder. Biological Psychiatry 2023, 93: s300-s301. DOI: 10.1016/j.biopsych.2023.02.751.
- Driesen N, Herman P, Rowland M, Thompson G, Qiu M, He G, Criscuolo E, Fineberg S, Barron D, Helgeson L, Lacadie C, Chow R, Gueorguieva R, Straun T, Krystal J, Hyder F. 430. Calibrated fMRI Sensitive to Ketamine-Related Increases Throughout the Cortex. Biological Psychiatry 2023, 93: s268-s269. DOI: 10.1016/j.biopsych.2023.02.670.
- Rahmati M, Moujaes F, Schleifer C, Ji J, Fonteneau C, Tamayo Z, Santamauro N, Respov G, Fineberg S, Krystal J, Murray J, Cho Y, Anticevic A. 248. Effects of NMDA Receptor Antagonist Ketamine on Neural Tuning. Biological Psychiatry 2023, 93: s193-s194. DOI: 10.1016/j.biopsych.2023.02.488.
- Girgenti M, Zhang J, Skarica M, Hwang A, Xu K, Young K, Zhao H, Sestan N, Krystal J. Single Cell Genomic Analysis Reveals Cell Type-Specific Molecular Signatures in the Human PTSD Prefrontal Cortex. Biological Psychiatry 2023, 93: s11-s12. DOI: 10.1016/j.biopsych.2023.02.049.
- Shinn M, Hu A, Turner L, Noble S, Preller K, Ji J, Moujaes F, Achard S, Scheinost D, Constable R, Krystal J, Vollenweider F, Lee D, Anticevic A, Bullmore E, Murray J. Functional brain networks reflect spatial and temporal autocorrelation. Nature Neuroscience 2023, 26: 867-878. PMID: 37095399, DOI: 10.1038/s41593-023-01299-3.
- Johnson T, Davis J, Smith B, Krystal J, Sevier B, Perry L, Clayton E, Black S. 93 Empowering the Next Generation of Clinical & Translational Scientists. Journal Of Clinical And Translational Science 2023, 7: 26-26. PMCID: PMC10129482, DOI: 10.1017/cts.2023.176.
- Johnson T, Black S, Smith B, Krystal J, Sevier B, Aly F, Kumpf B, Grover K, Solod A. 183 Explaining Research to Children and Adolescents. Journal Of Clinical And Translational Science 2023, 7: 56-57. PMCID: PMC10129822, DOI: 10.1017/cts.2023.261.
- Widge A, Jordan A, Kraguljac N, Sullivan C, Wilson S, Benton T, Alpert J, Carpenter L, Krystal J, Nemeroff C, Dzirasa K. Structural Racism in Psychiatric Research Careers: Eradicating Barriers to a More Diverse Workforce. American Journal Of Psychiatry 2023, 180: 645-659. PMID: 37073513, DOI: 10.1176/appi.ajp.20220685.
- Wunderlich G, Blahova Z, Hake S, Ikezawa S, Marder S, Falkai P, Krystal J. Efficacy and Safety of Iclepertin (BI 425809) in Patients With Schizophrenia: CONNEX, A Phase III Randomized Controlled Trial Program. CNS Spectrums 2023, 28: 229-229. DOI: 10.1017/s1092852923001530.
- Havlik J, Murphy M, Gong N, Tang D, Krystal J. Characteristics of Esketamine Prescribers Among Medicare Beneficiaries in the United States, 2019-2020. JAMA Network Open 2023, 6: e2311250. PMID: 37103934, PMCID: PMC10140803, DOI: 10.1001/jamanetworkopen.2023.11250.
- Jia R, Ruderman L, Pietrzak R, Gordon C, Ehrlich D, Horvath M, Mirchandani S, DeFontes C, Southwick S, Krystal J, Harpaz-Rotem I, Levy I. Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach. Translational Psychiatry 2023, 13: 101. PMID: 36977676, PMCID: PMC10050320, DOI: 10.1038/s41398-023-02388-4.
- Na P, Montalvo-Ortiz J, Petrakis I, Krystal J, Polimanti R, Gelernter J, Pietrzak R. Trajectories of alcohol consumption in U.S. military veterans: Results from a 10-year population-based longitudinal study. Drug And Alcohol Dependence 2023, 246: 109833. PMID: 36963160, PMCID: PMC10811960, DOI: 10.1016/j.drugalcdep.2023.109833.
- Falkai P, Reuteman-Fowler C, Blahova Z, Ikezawa S, Marder S, Krystal J. Efficacy and safety of iclepertin (BI 425809) in patients with schizophrenia: CONNEX, a Phase III randomised controlled trial programme. European Psychiatry 2023, 66: s637-s637. PMCID: PMC10661489, DOI: 10.1192/j.eurpsy.2023.1325.
- Fineberg S, Choi E, Shapiro-Thompson R, Dhaliwal K, Neustadter E, Sakheim M, Null K, Trujillo-Diaz D, Rondeau J, Pittaro G, Peters J, Corlett P, Krystal J. A pilot randomized controlled trial of ketamine in Borderline Personality Disorder. Neuropsychopharmacology 2023, 48: 991-999. PMID: 36804489, PMCID: PMC10209175, DOI: 10.1038/s41386-023-01540-4.
- Núñez-Rios D, Martínez-Magaña J, Nagamatsu S, Krystal J, Martínez-González K, Giusti-Rodríguez P, Montalvo-Ortiz J. Cross-Species Convergence of Brain Transcriptomic and Epigenomic Findings in Posttraumatic Stress Disorder: A Systematic Review. Complex Psychiatry 2023, 9: 100-118. PMID: 37404872, PMCID: PMC10315001, DOI: 10.1159/000529536.
- Fischer I, Na P, Harpaz-Rotem I, Krystal J, Pietrzak R. Characterization of Mental Health in US Veterans Before, During, and 2 Years After the Onset of the COVID-19 Pandemic. JAMA Network Open 2023, 6: e230463. PMID: 36821116, PMCID: PMC9951035, DOI: 10.1001/jamanetworkopen.2023.0463.
- Nagamatsu S, Rompala G, Hurd Y, Núñez-Rios D, Montalvo-Ortiz J, Group T, Alvarez V, Benedek D, Che A, Cruz D, Davis D, Girgenti M, Hoffman E, Holtzheimer P, Huber B, Kaye A, Krystal J, Labadorf A, Keane T, Logue M, McKee A, Marx B, Mash D, Miller M, Noller C, JM-O, Scott W, Schnurr P, Stein T, Ursano R, Williamson D, Wolf E, Young K. CpH methylome analysis in human cortical neurons identifies novel gene pathways and drug targets for opioid use disorder. Frontiers In Psychiatry 2023, 13: 1078894. PMID: 36745154, PMCID: PMC9892724, DOI: 10.3389/fpsyt.2022.1078894.
- Stanley I, Marx B, Fina B, Young-McCaughan S, Tyler H, Sloan D, Blankenship A, Dondanville K, Walker J, Boffa J, Bryan C, Brown L, Straud C, Mintz J, Abdallah C, Back S, Blount T, DeBeer B, Flanagan J, Foa E, Fox P, Fredman S, Krystal J, McDevitt-Murphy M, McGeary D, Pruiksma K, Resick P, Roache J, Shiroma P, Taylor D, Wachen J, Kaplan A, López-Roca A, Nicholson K, Schobitz R, Schrader C, Sharrieff A, Yarvis J, Litz B, Keane T, Peterson A. Psychometric Properties of the Self-Injurious Thoughts and Behaviors Interview–Short Form Among U.S. Active Duty Military Service Members and Veterans. Assessment 2023, 30: 2332-2346. PMID: 36644835, DOI: 10.1177/10731911221143979.
- Reuteman-Fowler C, Blahova Z, Ikezawa S, Marder S, Falkai P, Krystal J. Efficacy and safety of iclepertin (BI 425809) in patients with schizophrenia: CONNEX, a Phase III randomised controlled trial programme. Neuroscience Applied 2023, 2: 102592. DOI: 10.1016/j.nsa.2023.102592.
- Krystal J, Kane J, Correll C, Walling D, Leoni M, Duvvuri S, Patel S, Chang I, Iredale P, Frohlich L, Versavel S, Perry P, Sanchez R, Renger J. Emraclidine, a novel positive allosteric modulator of cholinergic M4 receptors, for the treatment of schizophrenia: a two-part, randomised, double-blind, placebo-controlled, phase 1b trial. The Lancet 2022, 400: 2210-2220. PMID: 36528376, DOI: 10.1016/s0140-6736(22)01990-0.
- Nagamatsu S, Pietrzak R, Xu K, Krystal J, Gelernter J, Montalvo‐Ortiz J. Dissecting the epigenomic differences between smoking and nicotine dependence in a veteran cohort. Addiction Biology 2022, 28: e13259. PMID: 36577721, DOI: 10.1111/adb.13259.
- Nichter B, Koller D, De Angelis F, Wang J, Girgenti M, Na P, Hill M, Norman S, Krystal J, Gelernter J, Polimanti R, Pietrzak R. Genetic liability to suicidal thoughts and behaviors and risk of suicide attempt in US military veterans: moderating effects of cumulative trauma burden. Psychological Medicine 2022, 53: 6325-6333. PMID: 36444557, DOI: 10.1017/s0033291722003646.
- Merians A, Spiller T, Harpaz-Rotem I, Krystal J, Pietrzak R. Post-traumatic Stress Disorder. Medical Clinics Of North America 2022, 107: 85-99. PMID: 36402502, DOI: 10.1016/j.mcna.2022.04.003.
- Kohler C, Wolf D, Abi-Dargham A, Anticevic A, Cho Y, Fonteneau C, Gil R, Girgis R, Gray D, Grinband J, Javitch J, Kantrowitz J, Krystal J, Lieberman J, Murray J, Ranganathan M, Santamauro N, Van Snellenberg J, Tamayo Z, Group T, D'Souza D, Srihari V, Gueorguieva R, Patel P, Forselius-Bielen K, Lu J, Butler A, Fram G, Afriyie-Agyemang Y, Selloni A, Cadavid L, Gomez-Luna S, Gupta A, Radhakrishnan R, Rashid A, Aker R, Abrahim P, Nia A, Surti T, Kegeles L, Carlson M, Goldberg T, Gangwisch J, Benedict E, Govil P, Brazis S, Mayer M, de la Garrigue N, Fallon N, Baumvoll T, Abeykoon S, Perlman G, Bobchin K, Elliott M, Schmidt L, Rush S, Port A, Heffernan Z, Laney N, Kantor J, Hohing T, Gur R, Gur R, Calkins M. Illness Phase as a Key Assessment and Intervention Window for Psychosis. Biological Psychiatry Global Open Science 2022, 3: 340-350. PMID: 37519466, PMCID: PMC10382701, DOI: 10.1016/j.bpsgos.2022.05.009.
- Aljishi A, Sandhu M, Shaikh N, Wise T, Krystal J, Kaye A, Damisah E. P143. Intracranial Electrophysiology of Amygdala-Insula Interactions in Anxiety. Biological Psychiatry 2022, 91: s144-s145. DOI: 10.1016/j.biopsych.2022.02.377.
- Shaikh N, Sandhu M, Aljishi A, Obaid S, Gu B, Krystal J, Kaye A, Damisah E. P142. Neural Correlates of Bodily Feedback During Spatial Threat Avoidance. Biological Psychiatry 2022, 91: s144. DOI: 10.1016/j.biopsych.2022.02.376.
- Nunez-Rios D, Rompala G, Hurd Y, Nagamatsu S, Martinez-Magaña J, Krystal J, Gelernter J, Montalvo-Ortiz T. P630. Multiomics Mapping of Posttraumatic Stress Disorder in Human Cortical Neurons. Biological Psychiatry 2022, 91: s344. DOI: 10.1016/j.biopsych.2022.02.867.
- Nagamatsu S, Pietrzak R, Na P, Krystal J, Gelernter J, Montalvo-Ortiz J. P79. Are Positive Psychosocial Traits Linked to Epigenetic Aging? Results From a National Sample of U.S. Military Veterans. Biological Psychiatry 2022, 91: s119. DOI: 10.1016/j.biopsych.2022.02.313.
- Swanberg K, Prinsen H, Averill C, Campos L, Kurada A, Krystal J, Petrakis I, Averill L, Abdallah C, Juchem C. Abnormal glutamate metabolism in prefrontal cortex of post-traumatic stress disorder linked to comorbidity with major depression. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2022 DOI: 10.58530/2022/3344.
- Bonomi R, Girgenti M, Krystal J, Cosgrove K. A Role for Histone Deacetylases in the Biology and Treatment of Post-Traumatic Stress Disorder: What Do We Know and Where Do We Go from Here? Complex Psychiatry 2022, 8: 13-27. PMID: 36545044, PMCID: PMC9669946, DOI: 10.1159/000524079.
- Pathak GA, Singh K, Wendt FR, Fleming TW, Overstreet C, Koller D, Tylee DS, De Angelis F, Cabrera Mendoza B, Levey DF, Koenen KC, Krystal JH, Pietrzak RH, O’ Donell C, Gaziano JM, Falcone G, Stein MB, Gelernter J, Pasaniuc B, Mancuso N, Davis LK, Polimanti R. Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits. Molecular Psychiatry 2022, 27: 1394-1404. PMID: 35241783, PMCID: PMC9210390, DOI: 10.1038/s41380-022-01488-9.
- Montalvo-Ortiz JL, Gelernter J, Cheng Z, Girgenti MJ, Xu K, Zhang X, Gopalan S, Zhou H, Duman RS, Southwick SM, Krystal JH, Pietrzak R. Epigenome-wide association study of posttraumatic stress disorder identifies novel loci in U.S. military veterans. Translational Psychiatry 2022, 12: 65. PMID: 35177594, PMCID: PMC8854688, DOI: 10.1038/s41398-022-01822-3.
- Krystal J. Edward F. Domino, Ph.D. (1924–2021). Neuropsychopharmacology 2022, 47: 1138-1139. PMCID: PMC8938419, DOI: 10.1038/s41386-022-01280-x.
- Barron D, Heisig S, Agurto C, Norel R, Quagan B, Powers A, Birnbaum M, Constable T, Cecchi G, Krystal J. Feasibility Analysis of Phenotype Quantification from Unstructured Clinical Interactions. Computational Psychiatry 2022, 6: 1. PMID: 38774775, PMCID: PMC11104416, DOI: 10.5334/cpsy.78.
- Wunderlich G, Blahova Z, Hake S, Ikezawa S, Marder S, Falkai P, Krystal J. Efficacy and safety of BI 425809 in patients with schizophrenia: CONNEX, a Phase III randomised controlled trial programme. Neuroscience Applied 2022, 1: 100342. DOI: 10.1016/j.nsa.2022.100342.
- Na PJ, De Angelis F, Nichter B, Wendt FR, Krystal JH, Southwick SM, Levey DF, Gelernter J, Polimanti R, Pietrzak RH. Psychosocial moderators of polygenic risk for suicidal ideation: Results from a 7-year population-based, prospective cohort study of U.S. veterans. Molecular Psychiatry 2021, 27: 1068-1074. PMID: 34725455, DOI: 10.1038/s41380-021-01352-2.
- Krystal J. Potential Schizophrenia Medications Point to New Disease Model. Psychiatric News 2021, 56 DOI: 10.1176/appi.pn.2021.11.37.
- Thompson SL, Gianessi CA, O'Malley SS, Cavallo DA, Shi JM, Tetrault JM, DeMartini KS, Gueorguieva R, Pittman B, Krystal JH, Taylor JR, Krishnan-Sarin S. Saracatinib Fails to Reduce Alcohol-Seeking and Consumption in Mice and Human Participants. Frontiers In Psychiatry 2021, 12: 709559. PMID: 34531767, PMCID: PMC8438169, DOI: 10.3389/fpsyt.2021.709559.
- Beck K, Hindley G, Borgan F, Ginestet C, McCutcheon R, Brugger S, Driesen N, Ranganathan M, D'Souza D, Taylor M, Krystal J, Howes O. The effect of ketamine on psychopathology and implications for understanding schizophrenia and its therapeutic use: a meta-analysis. BJPsych Open 2021, 7: s237-s237. PMCID: PMC8771247, DOI: 10.1192/bjo.2021.634.
- Girgenti M, Skarica M, Zhang J, Wang J, Friedman M, Zhao H, Krystal J. Integrative Functional Genomic Analysis of Human PTSD Molecular Pathology and Risk. Biological Psychiatry 2021, 89: s12. DOI: 10.1016/j.biopsych.2021.02.050.
- McClurkin M, Krystal J, Kaye A, Damisah E. Human iEEG Characterization of Threat and Anxiety Oscillations Across Amygdala, Hippocampus, and Frontal Cortex. Biological Psychiatry 2021, 89: s255. DOI: 10.1016/j.biopsych.2021.02.638.
- Barron D, Heisig S, Agurto C, Norel R, Quagan B, Powers A, Baker J, Constable T, Cecchi G, Krystal J. Preliminary Evaluation of Phenotypic Features from Clinical Interactions. Journal Of Pain 2021, 22: 594. DOI: 10.1016/j.jpain.2021.03.068.
- Wendt FR, Pathak GA, Levey DF, Nuñez YZ, Overstreet C, Tyrrell C, Adhikari K, De Angelis F, Tylee DS, Goswami A, Krystal JH, Abdallah CG, Stein MB, Kranzler HR, Gelernter J, Polimanti R. Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality. Neurobiology Of Stress 2021, 14: 100309. PMID: 33665242, PMCID: PMC7905234, DOI: 10.1016/j.ynstr.2021.100309.
- Girgenti MJ, Wang J, Ji D, Cruz DA, Stein M, Gelernter J, Young K, Huber B, Williamson D, Friedman M, Krystal J, Zhao H, Duman R. Transcriptomic organization of the human brain in post-traumatic stress disorder. Nature Neuroscience 2020, 24: 24-33. PMID: 33349712, DOI: 10.1038/s41593-020-00748-7.
- Krystal JH, Alvarado J, Ball SA, Fortunati FG, Hu M, Ivy ME, Kapo J, Olson KD, Rohrbaugh RM, Sinha R, Tebes JK, Vender RJ, Yonkers KA, Mayes LC. Mobilizing an institutional supportive response for healthcare workers and other staff in the context of COVID-19: The Yale experience. General Hospital Psychiatry 2020, 68: 12-18. PMID: 33254081, PMCID: PMC7680059, DOI: 10.1016/j.genhosppsych.2020.11.005.
- Moujaes F, Preller K, Vollenweider F, Schleifer C, Adkinson B, Kolobaric A, Fineberg S, Krystal J, Repovs G, Santamauro N, Morgan P, Savic A, Cho Y, D. M, Anticevic A. P.499 Ketamine's influence on global resting-state functional connectivity and individual variation in neuro-behavioural relationships. European Neuropsychopharmacology 2020, 40: s278-s279. DOI: 10.1016/j.euroneuro.2020.09.363.
- Krystal J. Robert T. Malison, M.D. (1959–2020). Neuropsychopharmacology 2020, 45: 2133-2134. PMCID: PMC7547671, DOI: 10.1038/s41386-020-00817-2.
- Bhatt S, Hillmer AT, Girgenti MJ, Rusowicz A, Kapinos M, Nabulsi N, Huang Y, Matuskey D, Angarita GA, Esterlis I, Davis MT, Southwick SM, Friedman MJ, Duman R, Carson R, Krystal J, Pietrzak R, Cosgrove K. PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies. Nature Communications 2020, 11: 2360. PMID: 32398677, PMCID: PMC7217830, DOI: 10.1038/s41467-020-15930-5.
- Girgenti M, Wang J, Ji D, Cruz D, Group T, Program M, Stein M, Gelernter J, Young K, Huber B, Williamson D, Friedman M, Krystal J, Zhao H, Duman R. Transcriptomic Organization of Human Posttraumatic Stress Disorder. Biological Psychiatry 2020, 87: s122. DOI: 10.1016/j.biopsych.2020.02.330.
- Stone L, Girgenti M, Krystal J, Duman R, Group T. Neural Transcriptomic Alterations Associated With Neuropeptide Y and Ghrelin in Posttraumatic Stress Disorder. Biological Psychiatry 2020, 87: s421-s422. DOI: 10.1016/j.biopsych.2020.02.1075.
- Nemati S, Akiki T, Ju Y, Averill C, Fouda S, Dutta A, Mckie S, Krystal J, Deakin B, Averill L, Abdallah C. A Shift in Executive Connectivity Predates and Predicts Response to Treatment in Major Depressive Disorder. Biological Psychiatry 2020, 87: s107. DOI: 10.1016/j.biopsych.2020.02.294.
- Barron D, Heisig S, Norel R, Agurto C, Quagan B, Powers A, Baker J, Constable R, Cecchi G, Krystal J. Preliminary Phenotypic Feature Capture During Clinical Interaction. Biological Psychiatry 2020, 87: s212-s213. DOI: 10.1016/j.biopsych.2020.02.552.
- Barron D, Bzdok D, Krystal J, Constable R. What Can Machine Learning Do for Psychiatry? Biological Psychiatry 2020, 87: s462. DOI: 10.1016/j.biopsych.2020.02.1176.
- Wendt F, Pathak G, Lencz T, Krystal J, Gelernter J, Polimanti R. Education and Socioeconomic Status Mask the Identification of Brain Cell Types in GWAS of Mental Health and Disease. Biological Psychiatry 2020, 87: s110. DOI: 10.1016/j.biopsych.2020.02.302.
- Koblan KS, Kent J, Hopkins SC, Krystal JH, Cheng H, Goldman R, Loebel A. A Non–D2-Receptor-Binding Drug for the Treatment of Schizophrenia. New England Journal Of Medicine 2020, 382: 1497-1506. PMID: 32294346, DOI: 10.1056/nejmoa1911772.
- Nestler E, Krystal J. Ronald S. Duman (1954–2020). Neuron 2020, 105: 769-770. DOI: 10.1016/j.neuron.2020.02.018.
- Abdallah CG, Averill LA, Gueorguieva R, Goktas S, Purohit P, Ranganathan M, Sherif M, Ahn KH, D’Souza D, Formica R, Southwick SM, Duman RS, Sanacora G, Krystal JH. Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin. Neuropsychopharmacology 2020, 45: 990-997. PMID: 32092760, PMCID: PMC7162891, DOI: 10.1038/s41386-020-0644-9.
- Krystal J, Nestler E, Picciotto M. Ronald S. Duman, Ph.D. (1954–2020). Neuropsychopharmacology 2020, 45: 1078-1078. PMCID: PMC7162938, DOI: 10.1038/s41386-020-0642-y.
- Krishnan-Sarin S, O’Malley S, Franco N, Cavallo DA, Tetrault JM, Shi J, Gueorguieva R, Pittman B, Krystal JH. Influence of combined treatment with naltrexone and memantine on alcohol drinking behaviors: a phase II randomized crossover trial. Neuropsychopharmacology 2019, 45: 319-326. PMID: 31590179, PMCID: PMC6901445, DOI: 10.1038/s41386-019-0536-z.
- Averill LA, Abdallah CG, Levey DF, Han S, Harpaz‐Rotem I, Kranzler HR, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study. Depression And Anxiety 2019, 36: 834-845. PMID: 31385647, DOI: 10.1002/da.22912.
- Davis MT, Hillmer A, Holmes SE, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Angarita G, Carson RE, Krystal JH, Esterlis I. In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 11490-11495. PMID: 31085640, PMCID: PMC6561298, DOI: 10.1073/pnas.1818871116.
- Cho Y, Schleifer C, Moujaes F, Starc M, Ji J, Santamauro N, Adkinson B, Kolobaric A, Flynn M, Krystal J, Murray J, Repovs G, Anticevic A. T193. Monetary Incentives Shape Behavioral and Neural Precision of Spatial Working Memory. Biological Psychiatry 2019, 85: s204-s205. DOI: 10.1016/j.biopsych.2019.03.516.
- Barron D, Gao S, Greene A, Constable R, Krystal J, Scheinost D. S179. Transdiagnostic Prediction of Memory and Executive Function From Whole-Brain Functional Connectivity. Biological Psychiatry 2019, 85: s366-s367. DOI: 10.1016/j.biopsych.2019.03.930.
- Moujaes F, Preller K, Vollenweider F, Schleifer C, Ji J, Adkinson B, Kolobaric A, Flynn M, Fineberg S, Krystal J, Repovs G, Santamauro N, Morgan P, Savic A, Cho Y, Murray J, Anticevic A. S159. NMDA Receptor Antagonism Effects on Delayed Spatial Working Memory and Distraction in Comparison With Schizophrenia. Biological Psychiatry 2019, 85: s358. DOI: 10.1016/j.biopsych.2019.03.910.
- Burt J, Preller K, Demirtas M, Ji J, Krystal J, Vollenweider F, Anticevic A, Murray J. S175. Large-Scale Model of Human Cortex Captures LSD-Induced Functional Alterations via HTR2A-Mediated Neural Gain Modulation. Biological Psychiatry 2019, 85: s365. DOI: 10.1016/j.biopsych.2019.03.926.
- Moujaes F, Schleifer C, Ji L, Adkinson B, Kolobaric A, Flynn M, Fineberg S, Krystal J, Repovs G, Cho Y, Santamauro N, Morgan P, Savic A, Murray J, Anticevic A. F195. NMDAR Antagonism via Ketamine Differentially Modulates Thalamic Versus Hippocampal Brain-Wide Functional Connectivity. Biological Psychiatry 2019, 85: s289. DOI: 10.1016/j.biopsych.2019.03.732.
- Hamilton H, Ford J, Roach B, Gunduz-Bruce H, Krystal J, Jaeger J, Reinhart R, Mathalon D. T161. Effects of Ketamine Administration on the P300 Event-Related Potential: Implications for Schizophrenia. Biological Psychiatry 2019, 85: s191. DOI: 10.1016/j.biopsych.2019.03.484.
- Kolobaric A, Anticevic A, Hu X, Xiao Y, Hu J, Li F, Bi F, Cole M, Savic A, Yang G, Repovs G, Murray J, Wang X, Huang X, Lui S, Krystal J, Gong Q. T174. Examining the Neurobiological Progression of Early Course Schizophrenia. Biological Psychiatry 2019, 85: s196-s197. DOI: 10.1016/j.biopsych.2019.03.497.
- Kaye A, Ressler K, Krystal J. S16. PTSD as a Threat Mood: Insights From a Reinforcement Learning Model. Biological Psychiatry 2019, 85: s302. DOI: 10.1016/j.biopsych.2019.03.767.
- Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Lower synaptic density is associated with depression severity and network alterations. Nature Communications 2019, 10: 1529. PMID: 30948709, PMCID: PMC6449365, DOI: 10.1038/s41467-019-09562-7.
- Duman RS, Sanacora G, Krystal JH. Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments. Neuron 2019, 102: 75-90. PMID: 30946828, PMCID: PMC6450409, DOI: 10.1016/j.neuron.2019.03.013.
- Krystal JH, Abdallah CG, Sanacora G, Charney DS, Duman RS. Ketamine: A Paradigm Shift for Depression Research and Treatment. Neuron 2019, 101: 774-778. PMID: 30844397, PMCID: PMC6560624, DOI: 10.1016/j.neuron.2019.02.005.
- Homan P, Levy I, Feltham E, Gordon C, Hu J, Li J, Pietrzak RH, Southwick S, Krystal JH, Harpaz-Rotem I, Schiller D. Neural computations of threat in the aftermath of combat trauma. Nature Neuroscience 2019, 22: 470-476. PMID: 30664770, PMCID: PMC6829910, DOI: 10.1038/s41593-018-0315-x.
- Preller KH, Burt JB, Ji JL, Schleifer CH, Adkinson BD, Stämpfli P, Seifritz E, Repovs G, Krystal JH, Murray JD, Vollenweider FX, Anticevic A. Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor. ELife 2018, 7: e35082. PMID: 30355445, PMCID: PMC6202055, DOI: 10.7554/elife.35082.
- Zhornitsky S, Ide J, Wang W, Chao H, Zhang S, Hu S, Krystal J, Li C. Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult Drinkers. Brain Connectivity 2018, 8: 487-502. PMID: 30198312, PMCID: PMC6207153, DOI: 10.1089/brain.2018.0633.
- Zhou H, Cheng Z, Bass N, Krystal JH, Farrer LA, Kranzler HR, Gelernter J. Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression. Translational Psychiatry 2018, 8: 208. PMID: 30287806, PMCID: PMC6172277, DOI: 10.1038/s41398-018-0258-8.
- Abdallah CG, De Feyter HM, Averill LA, Jiang L, Averill CL, Chowdhury GMI, Purohit P, de Graaf RA, Esterlis I, Juchem C, Pittman BP, Krystal JH, Rothman DL, Sanacora G, Mason GF. The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects. Neuropsychopharmacology 2018, 43: 2154-2160. PMID: 29977074, PMCID: PMC6098048, DOI: 10.1038/s41386-018-0136-3.
- Zhang X, Zhang X, Hu Y, Justice A, Li B, Wang Z, Zhao H, Krystal J, Xu K. DNA methylation signatures analysis with Illumina Infinitum MethylationEPIC and Infinium Human Methylation 450K BeadChip. Protocol Exchange 2018 DOI: 10.1038/protex.2018.080.
- Wilkinson S, Ostroff R, Katz R, Krystal J. Erratum to: Ketamine: A Promising Rapid-Acting Antidepressant. 2018, e1-e1. DOI: 10.1007/978-981-10-6577-4_24.
- Zhou H, Zhong Z, Bass N, Krystal J, Farrer L, Kranzler H, Gelernter J. F131. Genome-Wide Association Study Identifies Glutamate Ionotropic Receptor GRIA4 as a Risk Gene for Comorbid Nicotine Dependence and Major Depression. Biological Psychiatry 2018, 83: s288-s289. DOI: 10.1016/j.biopsych.2018.02.744.
- Cho Y, Schleifer C, Moujaes F, Starc M, Ji J, Santamauro N, Adkinson B, Lituchy M, Krystal J, Murray J, Repovs G, Anticevic A. S232. Effects of Incentive Presentation on Spatial Working Memory Performance. Biological Psychiatry 2018, 83: s438. DOI: 10.1016/j.biopsych.2018.02.1124.
- Girgenti M, Cruz D, Williamson D, Friedman M, Krystal J, Duman R. T103. Transcriptome Alterations for Posttraumatic Stress Disorder in Human Prefrontal Cortex. Biological Psychiatry 2018, 83: s168. DOI: 10.1016/j.biopsych.2018.02.439.
- Krystal J. 2. MICROCIRCUITS, MACROCIRCUITS, AND CORTICOL DYSFUNCTION IN SCHIZOPHRENIA: A COMPUTATIONAL AND TRANSLATIONAL NEUROSCIENCE PERSPECTIVE. Schizophrenia Bulletin 2018, 44: s1-s1. PMCID: PMC5887654, DOI: 10.1093/schbul/sby014.001.
- Anticevic A, Krystal J, Murray J. Meeting Emerging Challenges and Opportunities in Psychiatry Through Computational Neuroscience. 2018, xiii-xxxi. DOI: 10.1016/b978-0-12-809825-7.02004-6.
- Zhang X, Zhang X, Hu Y, Justice A, Li B, Wang Z, Zhao H, Krystal J, Xu K. DNA methylation signatures analysis with Illumina Infinitum MethylationEPIC and Infinium Human Methylation 450K BeadChip. Protocol Exchange 2017 DOI: 10.1038/protex.2017.135.
- Andersen AM, Pietrzak RH, Kranzler HR, Ma L, Zhou H, Liu X, Kramer J, Kuperman S, Edenberg HJ, Nurnberger JI, Rice JP, Tischfield JA, Goate A, Foroud TM, Meyers JL, Porjesz B, Dick DM, Hesselbrock V, Boerwinkle E, Southwick SM, Krystal JH, Weissman MM, Levinson DF, Potash JB, Gelernter J, Han S. Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence. JAMA Psychiatry 2017, 74: 1153-1160. PMID: 28813562, PMCID: PMC5710224, DOI: 10.1001/jamapsychiatry.2017.2269.
- Wilkinson S, Ostroff R, Katz R, Krystal J. Ketamine: A Promising Rapid-Acting Antidepressant. 2017, 223-239. DOI: 10.1007/978-981-10-6577-4_16.
- Krystal J. My Path to Psychiatry. Psychiatric News 2017, 52: 1-1. DOI: 10.1176/appi.pn.2017.10b1.
- Krystal J. KL.01.01 Targeting glutamate in psychiatric disease. European Neuropsychopharmacology 2017, 27: s521. DOI: 10.1016/s0924-977x(17)30985-9.
- Holmes SE, Girgenti MJ, Davis MT, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Duman RS, Carson RE, Krystal JH, Esterlis I, Friedman M, Kowall N, Brady C, McKee A, Stein T, Huber B, Kaloupek D, Alvarez V, Benedek D, Ursano R, Williamson D, Cruz D, Young K, Duman R, Krystal J, Mash D, Hardegree M, Serlin G. Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 8390-8395. PMID: 28716937, PMCID: PMC5547601, DOI: 10.1073/pnas.1701749114.
- Cortes-Briones J, Skosnik P, D’Souza D, Abdallah C, Petrakis I, Krystal J. 67 Ketamine-induced Changes in Neural Noise and their Relationship to Psychosis-like Symptoms. Biological Psychiatry 2017, 81: s28. DOI: 10.1016/j.biopsych.2017.02.078.
- Cho Y, Schleifer C, Starc M, Ji J, Santamauro N, Adkinson B, Lituchy M, Krystal J, Murray J, Repovs G, Anticevic A. 961 Incentives to Perform: The Effects of Reward on Working Memory. Biological Psychiatry 2017, 81: s389. DOI: 10.1016/j.biopsych.2017.02.687.
- Preller K, Schleifer C, Stämpfli P, Krystal J, Vollenweider F, Anticevic A. 951 Changes in Resting-State Global Brain Connectivity in LSD-Induced Altered States of Consciousness are Attributable to the 5-HT2A Receptor. Biological Psychiatry 2017, 81: s385. DOI: 10.1016/j.biopsych.2017.02.677.
- Davis M, Holmes S, Pietrzak R, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Carson R, Krystal J, Esterlis I. 18 In Vivo Quantification of mGluR5 Availability in Posttraumatic Stress Disorder. Biological Psychiatry 2017, 81: s8. DOI: 10.1016/j.biopsych.2017.02.029.
- Esterlis I, Pietrzak R, DellaGioia N, Matuskey D, Huang H, Krystal J, Duman R, Carson R, Finnema S. 389 In Vivo Evidence of Lower Synaptic Density in Depression and Associated Mood and Cognitive Deficits: A [11C]UCB-J PET Imaging Study. Biological Psychiatry 2017, 81: s159. DOI: 10.1016/j.biopsych.2017.02.406.
- Anticevic A, Schleifer C, Srihari V, Krystal J, Murray J, Repovs G, Xu G, Ji L, Cho Y, Santamauro N, Foss-Feig J, Yang G, Morgan P, Savic A. 423 NMDAR Antagonism via Ketamine Differentially Modulates Thalamic versus Hippocampal Functional Connectivity. Biological Psychiatry 2017, 81: s172-s173. DOI: 10.1016/j.biopsych.2017.02.907.
- Hamilton H, Kort N, Ford J, Roach B, Gunduz-Bruce H, Krystal J, Jaeger J, Reinhart R, Mathalon D. 540 Effects of N-methyl-D-aspartate Glutamate Receptor Disruption and Nicotinic Acetylcholine Enhancement on Mismatch Negativity. Biological Psychiatry 2017, 81: s219. DOI: 10.1016/j.biopsych.2017.02.1148.
- Akiki T, Averill C, Wrocklage K, Scott J, Alexander-Bloch A, Southwick S, Krystal J, Abdallah C. 581 The Default Mode Network in Posttraumatic Stress Disorder (PTSD): A Data-Driven Multimodal Approach. Biological Psychiatry 2017, 81: s235. DOI: 10.1016/j.biopsych.2017.02.451.
- Ferri J, Ford J, Roach B, Perry-O׳Leary D, Jaeger J, Gunduz-Bruce H, Krystal J, Mathalon D. 539 Ketamine, an NMDA-Receptor Antagonist, Mimics the Patterns of Intrinsically but Not Extrinsically Driven Gamma Oscillations. Biological Psychiatry 2017, 81: s218-s219. DOI: 10.1016/j.biopsych.2017.02.1147.
- Morey R, Logue M, van Rooij S, Dennis E, Davis S, Hayes J, Stevens J, Densmore M, Koch S, Korgaonkar M, LeBois L, Peverill M, Jahanshad N, Lagopoulos J, Gueze E, Jovanovic T, Abdallah C, Bennett M, King A, Krystal J, Bryant R, Miller M, Veltman D, McLaughlin K, Lanius R, Stein D, Thomaes K, Liberzon I, Ressler K, Thompson P. 87 Volume of Sub-Cortical Structures in Posttraumatic Stress Disorder from Multi-Site Investigation by ENIGMA and PGC Consortia. Biological Psychiatry 2017, 81: s36-s37. DOI: 10.1016/j.biopsych.2017.02.099.
- Krystal J, Anticevic A, Murray J, Glahn D, Driesen N, Yang G, Wang X. Clinical Heterogeneity Arising from Categorical and Dimensional Features of the Neurobiology of Psychiatric Diagnoses: Insights from Neuroimaging and Computational Neuroscience. 2016, 293-316. DOI: 10.7551/mitpress/10936.003.0023.
- Knickman J, Krishnan K, Pincus H, Blanco C, Blazer D, Coye M, Krystal J, Rauch S, Simon G, Vitiello B. Improving Access to Effective Care for People Who Have Mental Health and Substance Use Disorders: A Vital Direction for Health and Health Care. NAM Perspectives 2016, 6 DOI: 10.31478/201609v.
- Krystal J, Sanacora G, Abdallah C, Duman R. Speaker 4: John Krystal, USA. The International Journal Of Neuropsychopharmacology 2016, 19: 19-19. PMCID: PMC5616528, DOI: 10.1093/ijnp/pyw042.052.
- Duman RS, Aghajanian GK, Sanacora G, Krystal JH. Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nature Medicine 2016, 22: 238-249. PMID: 26937618, PMCID: PMC5405628, DOI: 10.1038/nm.4050.
- Yang GJ, Murray JD, Wang XJ, Glahn DC, Pearlson GD, Repovs G, Krystal JH, Anticevic A. Functional hierarchy underlies preferential connectivity disturbances in schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 113: e219-e228. PMID: 26699491, PMCID: PMC4720350, DOI: 10.1073/pnas.1508436113.
- Abdallah C, Krystal J. Ketamine. 2015, 857-862. DOI: 10.1007/978-3-642-36172-2_7031.
- Cosgrove KP, McKay R, Esterlis I, Kloczynski T, Perkins E, Bois F, Pittman B, Lancaster J, Glahn DC, O’Malley S, Carson RE, Krystal JH. Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 18031-18036. PMID: 25453062, PMCID: PMC4273348, DOI: 10.1073/pnas.1413947111.
- Wang XJ, Krystal JH. Computational Psychiatry. Neuron 2014, 84: 638-654. PMID: 25442941, PMCID: PMC4255477, DOI: 10.1016/j.neuron.2014.10.018.
- Baldan L, Williams K, Gallezot J, Pogorelov V, Rapanelli M, Crowley M, Anderson G, Loring E, Gorczyca R, Billingslea E, Wasylink S, Panza K, Ercan-Sencicek A, Krusong K, Leventhal B, Ohtsu H, Bloch M, Hughes Z, Krystal J, Mayes L, de Araujo I, Ding Y, State M, Pittenger C. Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice. Neuron 2014, 82: 1186-1187. DOI: 10.1016/j.neuron.2014.05.023.
- Abdallah C, Krystal J. Ketamine. 2014, 1-6. DOI: 10.1007/978-3-642-27772-6_7031-1.
- Rosenheck R, Leatherman S, Krystal J, Liang M. Poster #T200 SUBGROUP ANALYSIS IN A RANDOMIZED CLINICAL TRIAL OF LONG-ACTING INJECTABLE RISPERIDONE AND ORAL ANTIPSYCHOTICS IN UNSTABLE CHRONIC SCHIZOPHRENIA. Schizophrenia Research 2014, 153: s360. DOI: 10.1016/s0920-9964(14)71016-3.
- Anticevic A, Murray J, Repovs G, Starc M, Santamauro N, Savic A, Morgan P, Wang X, Krystal J. 5:45 PM INTEGRATING PHARMACOLOGY AND COMPUTATION: TOWARDS UNDERSTANDING MECHANISMS OF COGNITIVE AND CONNECTIVITY DEFICITS IN SCHIZOPHRENIA. Schizophrenia Research 2014, 153: s52-s53. DOI: 10.1016/s0920-9964(14)70172-0.
- Krystal JH, State MW. Psychiatric Disorders: Diagnosis to Therapy. Cell 2014, 157: 201-214. PMID: 24679536, PMCID: PMC4104191, DOI: 10.1016/j.cell.2014.02.042.
- Krystal J. S.19.04 Glutamatergic contributions to reward dysfunction in alcohol dependence. European Neuropsychopharmacology 2013, 23: s141. DOI: 10.1016/s0924-977x(13)70198-6.
- Krystal J. Pl.2 - KETAMINE. Behavioural Pharmacology 2013, 24: e1. DOI: 10.1097/01.fbp.0000434680.00108.7d.
- Jiang L, Gulanski BI, De Feyter HM, Weinzimer SA, Pittman B, Guidone E, Koretski J, Harman S, Petrakis IL, Krystal JH, Mason GF. Increased brain uptake and oxidation of acetate in heavy drinkers. Journal Of Clinical Investigation 2013, 123: 1605-1614. PMID: 23478412, PMCID: PMC3613911, DOI: 10.1172/jci65153.
- Anticevic A, Krystal J, Barch D. Translational cognitive neuroscience of schizophrenia: bridging neurocognitive and computational approaches toward understanding cognitive deficits. 2013, 193-230. DOI: 10.1017/cbo9781139003872.013.
- Anticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ, Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH, Corlett PR. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16720-16725. PMID: 23012427, PMCID: PMC3478611, DOI: 10.1073/pnas.1208494109.
- Stone J, Dietrich C, Edden R, Mehta M, De Simoni S, Reed L, Krystal J, Nutt D, Barker G. P.3.001 Ketamine-induced changes in anterior cingulate glutamate levels correlate with positive symptom generation. European Neuropsychopharmacology 2012, 22: s52-s53. DOI: 10.1016/s0924-977x(12)70054-8.
- Zuo L, Gelernter J, Zhang C, Zhao H, Lu L, Kranzler H, Malison R, Li C, Wang F, Zhang X, Deng H, Krystal J, Zhang F, Luo X. Erratum: Genome-Wide Association Study of Alcohol Dependence Implicates KIAA0040 on Chromosome 1q. Neuropsychopharmacology 2011, 37: 581-582. PMCID: PMC3242324, DOI: 10.1038/npp.2011.271.
- Kaffman A, Krystal J. Erratum: New Frontiers in Animal Research of Psychiatric Illness. 2011, 829: e1-e1. DOI: 10.1007/978-1-61779-458-2_38.
- Kaffman A, Krystal J. New Frontiers in Animal Research of Psychiatric Illness. 2011, 829: 3-30. PMID: 22231804, PMCID: PMC3337084, DOI: 10.1007/978-1-61779-458-2_1.
- Krystal JH, Rosenheck RA, Cramer JA, Vessicchio JC, Jones KM, Vertrees JE, Horney RA, Huang GD, Stock C, Group F. Adjunctive Risperidone Treatment for Antidepressant-Resistant Symptoms of Chronic Military Service–Related PTSD: A Randomized Trial. JAMA 2011, 306: 493-502. PMID: 21813427, DOI: 10.1001/jama.2011.1080.
- Krystal J. Biological Psychiatry: A Time of Opportunity, a Time of Challenge. Biological Psychiatry 2011, 70: 3-4. DOI: 10.1016/j.biopsych.2011.04.020.
- Krystal J, Petrakis I, Limoncelli D, Nappi S, Trevisan L, Pittman B, D'Souza D. Erratum: Characterization of the Interactive Effects of Glycine and D-Cycloserine in Men: Further Evidence for Enhanced NMDA Receptor Function Associated with Human Alcohol Dependence. Neuropsychopharmacology 2011, 36: 911-911. PMCID: PMC3055722, DOI: 10.1038/npp.2011.2.
- Krystal J, Moghaddam B. Contributions of Glutamate and GABA Systems to the Neurobiology and Treatment of Schizophrenia. 2010, 433-461. DOI: 10.1002/9781444327298.ch21.
- Nakic M, Krystal J, Bhagwagar Z. Neurotransmitter Systems in Bipolar Disorder. 2010, 210-227. DOI: 10.1002/9780470661277.ch16.
- Sen S, Kranzler H, Krystal J, Speller H, Chan G, Gelernter J, Guille C. In Reply. JAMA Psychiatry 2010, 67: 568-569. DOI: 10.1001/archgenpsychiatry.2010.53.
- Cavus I, Guglielmino R, Ford J, Roach B, Krystal J, Gueorguieva R, Mathalon D. IMPAIRED LONG-TERM POTENTIATION OF THE VISUAL EVOKED POTENTIAL IN SCHIZOPHRENIA. Schizophrenia Research 2010, 117: 244-245. DOI: 10.1016/j.schres.2010.02.373.
- Driesen N, McCarthy G, Bhagwagar Z, Calhoun V, D'Souza D, Holub J, Morgan P, Krystal J. NMDA Receptor Antagonist Ketamine Produces Opposing Effects on Resting and Task-Related Brain Activation During Working Memory in Humans. NeuroImage 2009, 47: s145. DOI: 10.1016/s1053-8119(09)71458-2.
- Krystal J. Biological Psychiatry: Real Progress. Biological Psychiatry 2009, 65: 3-4. DOI: 10.1016/j.biopsych.2008.08.026.
- Dickerson D, Pittman B, Ralevski E, Perrino A, Limoncelli D, Edgecombe J, Acampora G, Krystal J, Petrakis I. Ethanol-like effects of thiopental and ketamine in healthy humans. Journal Of Psychopharmacology 2008, 24: 203-211. PMID: 19028835, PMCID: PMC4484757, DOI: 10.1177/0269881108098612.
- Esterlis I, Bois F, Cosgrove K, Stiklus S, Perry E, Tamagnan G, Seibyl J, Krystal J, Staley J. Sex differences in nicotinic acetylcholine receptor availability in heavy alcohol drinkers. NeuroImage 2008, 41: t183. DOI: 10.1016/j.neuroimage.2008.04.150.
- Neumeister A, Czermak C, Henry S, Planeta-Wilson B, Huang H, Ding Y, Krystal J, Nabulsi N, Gallezot J, Carson R. Serotonin-1B receptor imaging in PTSD. NeuroImage 2008, 41: t163. DOI: 10.1016/j.neuroimage.2008.04.130.
- Urban N, Martinez D, Zhou Y, Toda M, Xu X, Kegeles L, Slifstein M, Pearlson G, Krystal J, Abi-Dargham A. New probes for imaging dopamine transmission in at risk subjects for alcoholism. NeuroImage 2008, 41: t143. DOI: 10.1016/j.neuroimage.2008.04.111.
- Heninger G, Krystal J, Duman R, Bunney B, Bowers M, Aghajanian G. The Neuroscience Research Program at the Connecticut Mental Health Center. 2007, 77-95. DOI: 10.1002/9780470994580.ch4.
- Krystal J. Biological Psychiatry: Increasing Impact. Biological Psychiatry 2007, 62: 1203-1204. DOI: 10.1016/j.biopsych.2007.09.021.
- Kaufman J, Massey J, Krystal J, Gelernter J. Reply. Biological Psychiatry 2007, 61: 1113-1115. DOI: 10.1016/j.biopsych.2006.07.004.
- Neumeister A, Charney D, Sanacora G, Krystal J. Neurobiology and Treatment of Depression. 2007 DOI: 10.1002/9780470101001.hcn018.
- D'Souza D, Krystal J. Psychoactive Drugs. 2006 DOI: 10.1002/0470018860.s00599.
- Staley J, Tellioglu T, Bois F, Palazzo C, McGuire-Schwartz N, Cosgrove K, van Dyck C, Tamagnan G, Seibyl J, Krystal J, D'Souza D. [I-123] 5-IA-85380 SPECT imaging of beta2-nicotinic acetylcholine receptors in recently abstinent mentally healthy and schizophrenic smokers. NeuroImage 2006, 31: t154. DOI: 10.1016/j.neuroimage.2006.04.137.
- Perry E, Gil R, Miles D, Brenner L, Macdougall L, Johnson R, Degen K, Gueorguieva R, Petrakis I, Krystal J, D'Souza D. Mazindol Augmentation of Antipsychotic Treatment for Schizophrenic Patients with Comorbid Cocaine Abuse or Dependence. Journal Of Dual Diagnosis 2005, 1: 37-47. DOI: 10.1300/j374v01n01_04.
- Mason G, Bendszus M, Meyerhoff D, Hetherington H, Schweinsburg B, Ross B, Taylor M, Krystal J. Magnetic Resonance Spectroscopic Studies of Alcoholism: From Heavy Drinking to Alcohol Dependence and Back Again. Alcohol Clinical And Experimental Research 2005, 29: 150-158. PMID: 15895489, DOI: 10.1097/01.alc.0000150010.72739.58.
- Daurignac E, Toga A, Jones D, Aronen H, Hommer D, Jernigan T, Krystal J, Mathalon D. Applications of Morphometric and Diffusion Tensor Magnetic Resonance Imaging to the Study of Brain Abnormalities in the Alcoholism Spectrum. Alcohol Clinical And Experimental Research 2005, 29: 159-166. PMID: 15895490, DOI: 10.1097/01.alc.0000150891.72900.62.
- Tsoy M, Krupitsky E, Neznanova O, Burakov A, Didenko T, Masalov D, Romanova T, Bespalov A, Zvartau E, Krystal J. P.3.10 Ethanol-like effects of N-methyl-d-aspartatereceptors antagonist memantine, and its ability to prevent cue induced alcohol craving. European Neuropsychopharmacology 2005, 15: s59-s60. DOI: 10.1016/s0924-977x(05)80177-4.
- Hoffman R, Mathalon D, Ford J, Krystal J. Cortico – (thalamo) – cortical interactions, gamma resonance, and auditory hallucinations in schizophrenia. Behavioral And Brain Sciences 2004, 27: 797-798. DOI: 10.1017/s0140525x04320182.
- Krupitsky E, Rudenko A, Burakov A, Zvartau E, Slavina T, Grinenko A, Krystal J. ANTI-GLUTAMATE TREATMENTS FOR ALCOHOL DETOXIFICATION: A DOUBLE-BLIND PLACEBO-CONTROLLED PILOT STUDY OF LAMOTRIGINE, MEMANTINE, AND TOPIRAMATE. Alcohol Clinical And Experimental Research 2004, 28: 50a. DOI: 10.1097/00000374-200408002-00258.
- Krishnan-Sarin S, Shih J, Krystal J, O’Malley S. HPA AXIS RESPONSIVITY AND ALCOHOL DRINKING: INTERACTIVE EFFECTS OF FAMILY HISTORY OF ALCOHOLISM AND NALTREXONE TREATMENT. Alcohol Clinical And Experimental Research 2004, 28: 73a. DOI: 10.1097/00000374-200408002-00397.
- Malhotra A, Krystal J. Molecular genetics and psychopharmacology. Psychopharmacology 2004, 174: 439-440. DOI: 10.1007/s00213-004-1947-y.
- Petrakis I, O’Malley S, Rounsaville B, Poling J, McHugh-Strong C, Krystal J, VA Naltrexone Study Collaboration Group. Naltrexone augmentation of neuroleptic treatment in alcohol abusing patients with schizophrenia. Psychopharmacology 2004, 174: 300-300. DOI: 10.1007/s00213-004-1881-z.
- D'souza D, Cho H, Perry E, Krystal J. Cannabinoid ‘model’ psychosis, dopamine–cannabinoid interactions and implications for schizophrenia. 2004, 142-165. DOI: 10.1017/cbo9780511543630.012.
- Cho H, Krystal J, D’Souza D. Blood dyscrasias. 2004, 221-238. DOI: 10.1093/med/9780198527480.003.0012.
- Qin J, Mitchell K, Johnson M, Krystal J, Southwick S, Rasmusson A, Allen E. Reactions to and memories for the September 11, 2001 terrorist attacks in adults with posttraumatic stress disorder. Applied Cognitive Psychology 2003, 17: 1081-1097. DOI: 10.1002/acp.987.
- Rasmusson A, Guidotti A, Charney D, Vojvoda D, Lipschitz D, Weisman D, Krystal J. S.20.01 Adrenal & CSF neurosteroids as mediators of HPA axis upregulation and symptom production in premenopausal women with PTSD. European Neuropsychopharmacology 2003, 13: s151-s152. DOI: 10.1016/s0924-977x(03)91680-4.
- Krystal J, D'Souza D, Mathalon D, Belger A, Perry E. S.01.03 Therapeutic implications of the NMDA receptor antagonist model psychosis. European Neuropsychopharmacology 2003, 13: s96. DOI: 10.1016/s0924-977x(03)91600-2.
- Cramer J, Rosenheck R, Kirk G, Krol W, Krystal J, 425 F. Medication Compliance Feedback and Monitoring in a Clinical Trial: Predictors and Outcomes. Value In Health 2003, 6: 566-573. PMID: 14627063, DOI: 10.1046/j.1524-4733.2003.65269.x.
- Hoffman R, Hawkins K, Anderson A, Buchanan R, Wu K, Hampson M, Gueorguieva R, Carroll K, Spencer D, Krystal J. One hertz repetitive transcranial magnetic stimulation delivered to brain areas underlying speech perception reduces persistent auditory hallucinations. Schizophrenia Research 2003, 60: 285-286. DOI: 10.1016/s0920-9964(03)80467-x.
- D'Souza D, Perry E, Riccardi P, Abi-Saab W, Krystal J. Cannabinoids and psychosis: Pharmacological studies with IV delta-9-THC in humans. Schizophrenia Research 2003, 60: 310. DOI: 10.1016/s0920-9964(03)80247-5.
- Jacobsen L, Mencl W, D'Souza D, Pugh K, Skudlarski P, Abi-Saab W, Krystal J. Impact of nicotine on brain function in smokers with schizophrenia. Schizophrenia Research 2003, 60: 223-224. DOI: 10.1016/s0920-9964(03)81196-9.
- Moghaddam B, Krystal J. The Neurochemistry of Schizophrenia. 2003, 349-364. DOI: 10.1002/9780470987353.ch19.
- Krystal J, Petrakis I, D'Souza D, Mason G, Trevisan L. Alcohol and Glutamate Neurotransmission in Humans: Implications for Reward, Dependence, and Treatment. 2002, 0: 389-398. DOI: 10.1385/1-59259-306-2:389.
- Petrakis I, Buonopane A, O???Malley S, Cermik O, Trevisan L, Boutros N, Limoncelli D, Krystal J. The Effect of Tryptophan Depletion on Alcohol Self-Administration in Non-Treatment-Seeking Alcoholic Individuals. Alcohol Clinical And Experimental Research 2002, 26: 969-975. DOI: 10.1097/00000374-200207000-00005.
- Cramer J, Rosenheck R, Krystal J, Kirk G, Krol W. PMH1 USEFULNESS OF ELECTRONIC COMPLIANCE DATA IN AN EFFECTIVENESS TRIAL. Value In Health 2002, 5: 226. DOI: 10.1016/s1098-3015(10)61067-4.
- Krystal J, Cramer J, Krol W, Kirk G, Rosenheck R. Naltrexone in the Treatment of Alcohol Dependence. New England Journal Of Medicine 2001, 345: 1734-1739. PMID: 11742047, DOI: 10.1056/nejmoa011127.
- Sierra M, Phillips M, Lambert M, Senior C, David A, Krystal J. Lamotrigine in the treatment of depersonalization disorder. The Journal Of Clinical Psychiatry 2001, 62: 826-7. PMID: 11816874, DOI: 10.4088/jcp.v62n1012b.
- Krystal J, D’Souza D. Comment on “ketamine has equal affinity for NMDA receptors and the high-affinity state of the dopamine D2 receptor”. Biological Psychiatry 2001, 50: 555. PMID: 11600110, DOI: 10.1016/s0006-3223(01)01258-6.
- Newcomer J, Krystal J. NMDA receptor regulation of memory and behavior in humans. Hippocampus 2001, 11: 529-542. PMID: 11732706, DOI: 10.1002/hipo.1069.
- Krupitsky E, Burakov A, Romanova T, Grinenko N, Grinenko A, Fletcher J, Petrakis I, Krystal J. Attenuation of Ketamine Effects by Nimodipine Pretreatment in Recovering Ethanol Dependent Men: Psychopharmacologic Implications of the Interaction of NMDA and L-Type Calcium Channel Antagonists. Neuropsychopharmacology 2001, 25: 936-947. PMID: 11750186, DOI: 10.1016/s0893-133x(01)00346-3.
- Petrakis I, Trevisan L, Boutros N, Limoncelli D, Cooney N, Krystal J. Effect of Tryptophan Depletion on Alcohol Cue-Induced Craving in Abstinent Alcoholic Patients. Alcohol Clinical And Experimental Research 2001, 25: 1151-1155. DOI: 10.1097/00000374-200108000-00009.
- Petrakis I, Trevisan L, Boutros N, Limoncelli D, Cooney N, Krystal J. Effect of Tryptophan Depletion on Alcohol Cue‐Induced Craving in Abstinent Alcoholic Patients. Alcohol Clinical And Experimental Research 2001, 25: 1151-1155. PMID: 11505046, DOI: 10.1111/j.1530-0277.2001.tb02329.x.
- Chambers R, Krystal J, Self D. A neurobiological basis for substance abuse comorbidity in schizophrenia. Biological Psychiatry 2001, 50: 71-83. PMID: 11526998, PMCID: PMC2913410, DOI: 10.1016/s0006-3223(01)01134-9.
- Krystal J, D'Souza D, Sanacora G, Goddard A, Charney D. CURRENT PERSPECTIVES ON THE PATHOPHYSIOLOGY OF SCHIZOPHRENIA, DEPRESSION, AND ANXIETY DISORDERS. Medical Clinics Of North America 2001, 85: 559-577. PMID: 11349473, DOI: 10.1016/s0025-7125(05)70329-1.
- Mason G, Behar K, Krystal J, Rothman D. Aplicações da ressonância magnética para medidas espectroscópicas da neurotransmissão. Brazilian Journal Of Psychiatry 2001, 23: 6-10. DOI: 10.1590/s1516-44462001000500004.
- Stine S, Grillon C, Morgan III C, Kosten T, Charney D, Krystal J. Methadone patients exhibit increased startle and cortisol response after intravenous yohimbine. Psychopharmacology 2001, 154: 274-281. PMID: 11351934, DOI: 10.1007/s002130000644.
- Boutros N, Lisanby S, Tokuno H, Torello M, Campbell D, Berman R, Malison R, Krystal J, Kosten T. Elevated motor threshold in drug-free, cocaine-dependent patients assessed with transcranial magnetic stimulation. Biological Psychiatry 2001, 49: 369-373. PMID: 11239908, DOI: 10.1016/s0006-3223(00)00948-3.
- D'Souza D, Krystal J. Psychopharmacological challenge studies in psychiatric research. International Review Of Psychiatry 2001, 13: 40-46. DOI: 10.1080/09540260020024187.
- D'Souza D, Krystal J. Psychopharmacological challenge studies in psychiatric research. International Review Of Psychiatry 2001, 13: 40-46. DOI: 10.1080/09540260123077.
- Boutros N, Reid M, Petrakis I, Campbell D, Torello M, Krystal J. Similarities in the Disturbances in Cortical Information Processing in Alcoholism and Aging: A Pilot Evoked Potential Study. International Psychogeriatrics 2000, 12: 513-525. PMID: 11263717, DOI: 10.1017/s1041610200006621.
- Krystal J, Belger A, Abi-Saab W, Moghaddam B, Charney D, Anand A, Madonick S, D’Souza C. Glutamatergic contributions to cognitive dysfunction in schizophrenia. 2000, 126-153. DOI: 10.1093/oso/9780192629937.003.0007.
- Boutros N, Campbell D, Petrakis I, Krystal J, Caporale M, Kosten T. Cocaine use and the mid-latency auditory evoked responses. Psychiatry Research 2000, 96: 117-126. PMID: 11063784, DOI: 10.1016/s0165-1781(00)00207-9.
- Abi-Dargham A, Krystal J. Serotonin Receptors as Targets of Antipsychotic Medications. 2000, 20000744: 79-107. DOI: 10.1201/9781420041774.ch6.
- George T, Krystal J. Comorbidity of psychiatric and substance abuse disorders. Current Opinion In Psychiatry 2000, 13: 327-331. DOI: 10.1097/00001504-200005000-00015.
- Hoffman R, Boutros N, Berman R, Hu S, Rachid F, Schaffer N, Krystal J, Charney D. 401. One Hertz rTMS of left temporoparietal cortex in schizophrenic patients reporting auditory hallucinations. Biological Psychiatry 2000, 47: s122-s123. DOI: 10.1016/s0006-3223(00)00670-3.
- Abi-Saab W, Spencer D, Srihari V, Thompson J, Roth R, Sherwin R, Krystal J. 458. Extracellular levels of GABA and glutamate increase in response to direct electrical stimulation of the hippocampus in humans: an in vivo microdialysis study. Biological Psychiatry 2000, 47: s140. DOI: 10.1016/s0006-3223(00)00728-9.
- Belger A, Krystal J. 203. Working memory: constructs, neural circuits, and pharmacological modulation. Biological Psychiatry 2000, 47: s62. DOI: 10.1016/s0006-3223(00)00295-x.
- Boutros N, Reid C, Campbell D, Torello M, Krystal J. 455. Sensory gating in older healthy adults. Biological Psychiatry 2000, 47: s139. DOI: 10.1016/s0006-3223(00)00725-3.
- Laruelle M, Abi-Dargham A, van Dyck C, Gil R, D’Souza D, Krystal J, Seibyl J, Baldwin R, Innis R. Dopamine and serotonin transporters in patients with schizophrenia: an imaging study with [123I]β-CIT. Biological Psychiatry 2000, 47: 371-379. PMID: 10704949, DOI: 10.1016/s0006-3223(99)00257-7.
- Hoffman R, Boutros N, Hu S, Berman R, Krystal J, Charney D. Transcranial magnetic stimulation and auditory hallucinations in schizophrenia. The Lancet 2000, 355: 1073-1075. PMID: 10744097, DOI: 10.1016/s0140-6736(00)02043-2.
- D’Souza D, Gil R, Cassello K, Morrissey K, Abi-Saab D, White J, Sturwold R, Bennett A, Karper L, Zuzarte E, Charney D, Krystal J. IV glycine and oral d-cycloserine effects on plasma and CSF amino acids in healthy humans. Biological Psychiatry 2000, 47: 450-462. PMID: 10704956, DOI: 10.1016/s0006-3223(99)00133-x.
- Berman R, Cappiello A, Anand A, Oren D, Heninger G, Charney D, Krystal J. Antidepressant effects of ketamine in depressed patients. Biological Psychiatry 2000, 47: 351-354. PMID: 10686270, DOI: 10.1016/s0006-3223(99)00230-9.
- Sanacora G, Mason G, Krystal J. Impairment of GABAergic Transmission in Depression: New Insights from Neuroimaging Studies. Critical Reviews In Neurobiology 2000, 14: 23. PMID: 11253954, DOI: 10.1615/critrevneurobiol.v14.i1.20.
- Krystal J, Bennett A, Abi-Saab D, Belger A, Karper L, D’Souza D, Lipschitz D, Abi-Dargham A, Charney D. Dissociation of ketamine effects on rule acquisition and rule implementation: possible relevance to NMDA receptor contributions to executive cognitive functions. Biological Psychiatry 2000, 47: 137-143. PMID: 10664830, PMCID: PMC10060085, DOI: 10.1016/s0006-3223(99)00097-9.
- Anand A, Berman R, Charney D, Krystal J. Attenuation of ketamine effects in healthy humans by lamotrigine, a drug that reduces glutamate release. Schizophrenia Research 2000, 41: 33. DOI: 10.1016/s0920-9964(00)90372-4.
- Krystal J, D'Souza D, Belger A, Madonick S, Cossello K. Ketamine and amphetamine interactions in healthy humans: Further insights into glutamate-dopamine interactions. Schizophrenia Research 2000, 41: 235-236. DOI: 10.1016/s0920-9964(00)90891-0.
- D'Souza D, Madonick S, Abi-Saab W, Wray Y, MacDougall L, Brush L, Cassello K, Krystal J. Dose-response of acute ethanol administration in schizophrenic patients and controls. Schizophrenia Research 2000, 41: 247. DOI: 10.1016/s0920-9964(00)90923-x.
- D'Souza D, Abi-Saab W, Madonick S, Wray Y, Forselius K, MacDougall L, Brush L, Cassello K, Krystal J. Cannabinoids & psychosis: Evidence from studies with I.V THC in schizophrenic patients and controls. Schizophrenia Research 2000, 41: 33. DOI: 10.1016/s0920-9964(00)90371-2.
- Krystal J, Bremner J, D’Souza D, Anand A, Southwick S, Charney D. The Emerging Neurobiology of Dissociative States. 2000, 307-320. DOI: 10.1007/978-1-4615-4177-6_22.
- Gibbons R, Brown B, Azarnoff D, Bunney W, Cancro R, Gillin J, Hullett S, Killam K, Krystal J, Kupfer D, Stolley P, Pope A, French G. Assessment of the Safety and Efficacy Data for the Hypnotic Halcion(R): Results of an Analysis by an Institute of Medicine Committee. Journal Of The American Statistical Association 1999, 94: 993-1002. DOI: 10.1080/01621459.1999.10473852.
- Gibbons R, Brown B, Azarnoff D, Bunney W, Cancro R, Gillin J, Hullett S, Killam K, Krystal J, Kupfer D, Stolley P, Pope A, French G. Assessment of the Safety and Efficacy Data for the Hypnotic Halcion (R) : Results of an Analysis by an Institute of Medicine Committee. Journal Of The American Statistical Association 1999, 94: 993. DOI: 10.2307/2669913.
- Krystal J, Belger A, D'Souza D, Anand A, Charney D, Aghajanian G, Moghaddam B. Therapeutic Implications of the Hyperglutamatergic Effects of NMDA Antagonists. Neuropsychopharmacology 1999, 21: s143-s157. DOI: 10.1016/s0893-133x(99)00102-5.
- Boutros N, Belger A, Campbell D, D’Souza C, Krystal J. Comparison of four components of sensory gating in schizophrenia and normal subjects: a preliminary report. Psychiatry Research 1999, 88: 119-130. PMID: 10622348, DOI: 10.1016/s0165-1781(99)00074-8.
- Verhoeff N, Soares J, D’Souza C, Gil R, Degen K, Abi-Dargham A, Zoghbi S, Fujita M, Rajeevan N, Seibyl J, Krystal J, van Dyck C, Charney D, Innis R. [123I]Iomazenil SPECT benzodiazepine receptor imaging in schizophrenia. Psychiatry Research 1999, 91: 163-173. PMID: 10641580, DOI: 10.1016/s0925-4927(99)00027-x.
- D’Souza D, Berman R, Krystal J, Charney D. Symptom provocation studies in psychiatric disorders: scientific value, risks, and future. Biological Psychiatry 1999, 46: 1060-1080. PMID: 10536743, DOI: 10.1016/s0006-3223(99)00209-7.
- Krystal J, D'Souza C, Petrakis I, Belger A, Berman R, Charney D, AbiSaab W, Madonick S. NMDA Agonists and Antagonists as Probes of Glutamatergic Dysfunction and Pharmacotherapies in Neuropsychiatric Disorders. Harvard Review Of Psychiatry 1999, 7: 125-143. PMID: 10483932, DOI: 10.3109/hrp.7.3.125.
- Krystal J. NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disorders. Harvard Review Of Psychiatry 1999, 7: 125-143. DOI: 10.1093/hrp/7.3.125.
- Krupitsky E, Burakov A, Romanova T, Vegso S, Krystal J. Nimodipine attenuates psychotigenic effects of ketamine in humans. European Neuropsychopharmacology 1999, 9: 347. DOI: 10.1016/s0924-977x(99)80514-8.
- Petrakis I, Trevisan L, D'Souza C, Gil R, Krasnicki S, Webb E, Heninger G, Cooney N, Krystal J. CSF Monoamine Metabolite and Beta Endorphin Levels in Recently Detoxified Alcoholics and Healthy Controls. Alcohol Clinical And Experimental Research 1999, 23: 1336. DOI: 10.1097/00000374-199908000-00007.
- Petrakis I, Trevisan L, D'Souza C, Gil R, Krasnicki S, Webb E, Heninger G, Cooney N, Krystal J. CSF Monoamine Metabolite and Beta Endorphin Levels in Recently Detoxified Alcoholics and Healthy Controls: Prediction of Alcohol Cue‐Induced Craving? Alcohol Clinical And Experimental Research 1999, 23: 1336-1341. PMID: 10470976, DOI: 10.1111/j.1530-0277.1999.tb04355.x.
- Hoffman R, Boutros N, Berman R, Roessler E, Belger A, Krystal J, Charney D. Transcranial magnetic stimulation of left temporoparietal cortex in three patients reporting hallucinated “voices”. Biological Psychiatry 1999, 46: 130-132. PMID: 10394483, DOI: 10.1016/s0006-3223(98)00358-8.
- Krystal J, D’Souza D, Karper L, Bennett A, Abi-Dargham A, Abi-Saab D, Cassello K, Bowers Jr. M, Vegso S, Heninger G, Charney D, Bowers M. Interactive effects of subanesthetic ketamine and haloperidol in healthy humans. Psychopharmacology 1999, 145: 193-204. PMID: 10463321, DOI: 10.1007/s002130051049.
- Delgado P, Miller H, Salomon R, Licinio J, Krystal J, Moreno F, Heninger G, Charney D. Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action. Biological Psychiatry 1999, 46: 212-220. PMID: 10418696, DOI: 10.1016/s0006-3223(99)00014-1.
- Abi-Dargham A, Laruelle M, Krystal J, D'Souza C, Zoghbi S, Baldwin R, Seibyl J, Mawlawi O, de Erasquin G, Charney D, Innis R. No Evidence of Altered In Vivo Benzodiazepine Receptor Binding in Schizophrenia. Neuropsychopharmacology 1999, 20: 650-661. PMID: 10327433, DOI: 10.1016/s0893-133x(98)00107-9.
- Sanacora G, Rothman D, Krystal J. Applications of Magnetic Resonance Spectroscopy to Psychiatry. The Neuroscientist 1999, 5: 192-196. DOI: 10.1177/107385849900500316.
- Fujita M, Woods S, Verhoeff N, Abi-Dargham A, Baldwin R, Zoghbi S, Soares J, Jatlow P, Krystal J, Rajeevan N, Charney D, Seibyl J, Innis R. Changes of benzodiazepine receptors during chronic benzodiazepine administration in humans. European Journal Of Pharmacology 1999, 368: 161-172. PMID: 10193652, DOI: 10.1016/s0014-2999(99)00013-8.
- Sanacora G, Mason G, Rothman D, Berman R, Charney D, Ciarcia J, Krystal J. 1. ECT Effects on Cortical GABA Levels as Determined by 1H-MRS. Journal Of Ect 1999, 15: 102. DOI: 10.1097/00124509-199903000-00009.
- Krystal J, D'Souza D, Madonick S, Petrakis I. Toward a rational pharmacotherapy of comorbid substance abuse in schizophrenic patients. Schizophrenia Research 1999, 35: s35-s49. PMID: 10190224, DOI: 10.1016/s0920-9964(98)00162-5.
- Belger A, Puce A, Krystal J, Gore J, Goldman‐Rakic P, McCarthy G. Dissociation of mnemonic and perceptual processes during spatial and nonspatial working memory using fMRI. Human Brain Mapping 1998, 6: 14-32. PMID: 9673660, PMCID: PMC6873355, DOI: 10.1002/(sici)1097-0193(1998)6:1<14::aid-hbm2>3.0.co;2-o.
- Sernyak M, Glazer W, Heninger G, Charney D, Woods S, Petrakis I, Krystal J, Price L. Naltrexone Augmentation of Neuroleptics in Schizophrenia. Journal Of Clinical Psychopharmacology 1998, 18: 248-251.. PMID: 9617985, DOI: 10.1097/00004714-199806000-00011.
- Hoffman R, Boutros N, Berman R, Krystal J, Charney D. 310. Transcranial magnetic stimulation and hallucinated ‘voices’. Biological Psychiatry 1998, 43: s93. DOI: 10.1016/s0006-3223(98)90758-2.
- Boutros N, Krystal J, Gelernter J. 295. Sensory gating and cocaine induced paranoia. Biological Psychiatry 1998, 43: s89. DOI: 10.1016/s0006-3223(98)90743-0.
- D'Souza D, Belger A, Abi-Saab W, Adams S, Gil R, Larvey K, Cassello K, Sernyak M, Krystal J. 435. Dose-response of THC effects in schizophrenics and healthy controls. Biological Psychiatry 1998, 43: s130-s131. DOI: 10.1016/s0006-3223(98)90883-6.
- Krystal J, Moghaddam B, Breier A, Goldman-Rakic P, McElvey J. 204. Glutamate, dopamine, the frontal cortex, and schizophrenia. Biological Psychiatry 1998, 43: s60. DOI: 10.1016/s0006-3223(98)90652-7.
- Hillbrand M, Spitz R, Foster H, Krystal J, Young J. Creatine Kinase Elevations and Aggressive Behavior in Hospitalized Forensic Patients. Psychiatric Quarterly 1998, 69: 69-82. PMID: 9536476, DOI: 10.1023/a:1022137524475.
- Krystal J. Excitatory Amino Acids: Clinical Results with Antagonists. The Yale Journal Of Biology And Medicine 1998, 71: 409-410. PMCID: PMC2578927.
- Belger A, Kirino E, McCarthy G, Gore J, Krystal J. Assessment of prefrontal activation by infrequent visual targets and non-target novel stimuli in schizophrenia: A functional MRI study. Schizophrenia Research 1998, 29: 106. DOI: 10.1016/s0920-9964(97)88567-2.
- Krystal J, Karper L, Bennett A, D’Souza D, Abi-Dargham A, Morrissey K, Abi-Saab D, Bremner J, Bowers Jr. M, Suckow R, Stetson P, Heninger G, Charney D. Interactive effects of subanesthetic ketamine and subhypnotic lorazepam in humans. Psychopharmacology 1998, 135: 213-229. PMID: 9498724, DOI: 10.1007/s002130050503.
- Measurement of dissociative states with the Clinician‐Administered Dissociative States Scale (CADSS)Bremner J, Krystal J, Putnam F, Southwick S, Marmar C, Charney D, Mazure C. Measurement of dissociative states with the Clinician‐Administered Dissociative States Scale (CADSS). Journal Of Traumatic Stress 1998, 11: 125-136. PMID: 9479681, DOI: 10.1023/a:1024465317902.
- Krystal J, Nagy L, Rasmusson A, Morgan A, Cottrol C, Southwick S, Charney D. Initial Clinical Evidence of Genetic Contributions to Posttraumatic Stress Disorder. 1998, 657-667. DOI: 10.1007/978-1-4757-5567-1_39.
- Abi-Dargham A, Charney D, Krystal J. Benzodiazepine Receptor Antagonists. CNS Drugs 1997, 8: 244-256. DOI: 10.2165/00023210-199708030-00007.
- Stine S, Krystal J, Petrakis I, Jatlow P, Heninger G, Kosten T, Chamey D. Effect of alpha-methyl-para-tyrosine on response to cocaine challenge. Biological Psychiatry 1997, 42: 181-190. PMID: 9232210, DOI: 10.1016/s0006-3223(96)00331-9.
- SOUTHWICK S, MORGAN CA, BREMNER A, GRILLON C, KRYSTAL J, NAGY L, CHARNEY D. Noradrenergic Alterations in Posttraumatic Stress Disorder. Annals Of The New York Academy Of Sciences 1997, 821: 125-141. PMID: 9238199, DOI: 10.1111/j.1749-6632.1997.tb48274.x.
- Krystal J, Webb E, Grillon C, Cooney N, Casal L, Morgan III. C, Southwick S, Davis M, Charney D. Evidence of acoustic startle hyperreflexia in recently detoxified early onset male alcoholics: modulation by yohimbine and m-Chlorophenylpiperazine (mCPP). Psychopharmacology 1997, 131: 207-215. PMID: 9203230, DOI: 10.1007/s002130050285.
- Cramer J, Krystal J, Rosenheck R, Rounsaville B, Krol W, Collins J. P111 Protocol enhancements for a study of alcohol-dependent patients. Contemporary Clinical Trials 1997, 18: s179. DOI: 10.1016/s0197-2456(97)91206-x.
- Zuzarte E, D’Souza D, Gil R, Genovese A, White J, Charney D, Krystal J. 617 Dose-related ethanol effects in schizophrenic patients. Schizophrenia Research 1997, 24: 218. DOI: 10.1016/s0920-9964(97)82625-4.
- Behar K, Rothman D, D’Souza D, Gil R, Petroff O, Abi-Saab D, Zuzarte E, Hooten M, Petrakis I, Sernyak M, White J, Webb E, Charnay D, Krystal J. 496 Preliminary assessment of cortical gaba levels in schizophrenics using magnetic resonance spectroscopy. Schizophrenia Research 1997, 24: 175-176. DOI: 10.1016/s0920-9964(97)82504-2.
- Salomon R, Miller H, Krystal J, Heninger G, Charney D. Lack of behavioral effects of monoamine depletion in healthy subjects. Biological Psychiatry 1997, 41: 58-64. PMID: 8988796, DOI: 10.1016/0006-3223(95)00670-2.
- D’Souza D, Gil R, Zuzarte E, Zimmerman L, Abi-Saab D, Damon D, White J, Semyak M, Krystal J. 602 Tetrahydrocannabinol effects in schizophrenic subjects & healthy controls. Schizophrenia Research 1997, 24: 213. DOI: 10.1016/s0920-9964(97)82610-2.
- Belger A, McNulty A, Krystal J. 356 Behavioral assessment of frontal/ cingulate attention deficits in schizophrenia. Schizophrenia Research 1997, 24: 129. DOI: 10.1016/s0920-9964(97)82364-x.
- Belger A, Taqqu Y, Krystal J. 357 Behavioral dissociation of working memory and selective attention functions in schizophrenia. Schizophrenia Research 1997, 24: 129-130. DOI: 10.1016/s0920-9964(97)82365-1.
- D’Souza D, Gil R, Zuzarte E, Abi-Saab D, Damon D, White J, Zimmerman L, Krystal J. 601 Glycine ketamine interactions in healthy humans. Schizophrenia Research 1997, 24: 213. DOI: 10.1016/s0920-9964(97)82609-6.
- Zuzarte E, D’Souza D, Gil R, White J, AbiSaab D, Charney D, Krystal J. 618 Evaluation of lorazepam blockade of M-chlorophenylpiperazine (MCPP) effects in schizophrenia. Schizophrenia Research 1997, 24: 218. DOI: 10.1016/s0920-9964(97)82626-6.
- Laruelle M, Abi-Dargham A, Krystal J, Charney D, Innis R. 507 In vivo evaluation of dopamine synaptic funcflon in untreated schizophrenic patients. Schizophrenia Research 1997, 24: 179. DOI: 10.1016/s0920-9964(97)82515-7.
- Petrakis I, Satel S, Stine S, Kosten T, Namanworth S, Charney D, Krystal J. AMPT Effects on Cue‐Induced Craving for Cocaine. American Journal On Addictions 1996, 5: 313-320. DOI: 10.1111/j.1521-0391.1996.tb00317.x.
- McCarthy G, Puce A, Constable T, Krystal J, Gore J, Goldman-Rakic P. Activation of Human Prefrontal Cortex during Spatial and Nonspatial Working Memory Tasks Measured by Functional MRI. Cerebral Cortex 1996, 6: 600-611. PMID: 8670685, DOI: 10.1093/cercor/6.4.600.
- D’Souza D, Abi-Saab D, Damon D, White J, Gil R, Krystal J. O-22-11 Dose response of D-Cycloserine, a partial NMDA-Glycine site agonist, in schizophrenia. European Neuropsychopharmacology 1996, 6: 149. DOI: 10.1016/0924-977x(96)87994-6.
- Bremner J, Krystal J, Southwick S, Charney D. Noradrenergic mechanisms in stress and anxiety: II. Clinical studies. Synapse 1996, 23: 39-51. PMID: 8723134, DOI: 10.1002/(sici)1098-2396(199605)23:1<39::aid-syn5>3.0.co;2-i.
- Bremner J, Krystal J, Southwick S, Charney D. Noradrenergic mechanisms in stress and anxiety: I. preclinical studies. Synapse 1996, 23: 28-38. PMID: 8723133, DOI: 10.1002/(sici)1098-2396(199605)23:1<28::aid-syn4>3.0.co;2-j.
- Krystal J, Compere S, Nestler E, Rasmussen K. Nimodipine reduction of naltrexone-precipitated locus coeruleus activation and abstinence behavior in morphine-dependent rats. Physiology & Behavior 1996, 59: 863-866. PMID: 8778878, DOI: 10.1016/0031-9384(95)02206-6.
- Laruelle M, Abi-Dargham A, van Dyck C, Krystal J, Charney D, Innis R. 208. Increased striatal dopamine release in drug free schizophrenic subjects. Biological Psychiatry 1996, 39: 560. DOI: 10.1016/0006-3223(96)84153-9.
- Gil R, D’Souza D, Zuzarte E, Damon D, Genovese A, Boutros N, Abi-Dargham A, Innis R, Charney D, Krystal J. 326. GABA-serotonin interactions in healthy subjects: Implications for psychosis. Biological Psychiatry 1996, 39: 595-596. DOI: 10.1016/0006-3223(96)84271-5.
- Hillbrand M, Young J, Krystal J. Recurrent self-injurious behavior in forensic patients. Psychiatric Quarterly 1996, 67: 33-45. PMID: 8623037, DOI: 10.1007/bf02244273.
- Laruelle M, Abi-Dargham A, Gil R, van Dyck C, Erdos J, D'Souza D, Rosenblatt W, McCance-Katz E, Zea-Ponce Y, Zoghbi S, Baldwin R, Hoffer P, Krystal J, Charney D, Innis R. SPECT imaging of synaptic dopamine release in drug free schizophrenic patients: An experimental validation of the dopamine hypothesis of schizophrenia. Schizophrenia Research 1996, 18: 198-199. DOI: 10.1016/0920-9964(96)85619-2.
- D'Souza D, White J, Abi-Saab D, Damon D, Gil R, Zuzarte E, Krystal J. Dose response of oral D-cycloserine in unmedicated and medicated schizophrenics. Schizophrenia Research 1996, 18: 134. DOI: 10.1016/0920-9964(96)85447-8.
- Petrakis I, Satel S, Stine S, Kosten T, Namanworth S, Charney D, Krystal J. AMPT Effects on Cue-Induced Craving for Cocaine. American Journal On Addictions 1996, 5: 313-320. DOI: 10.3109/10550499608995682.
- Krystal J, Bennett A, Bremner J, Southwick S, Charney D. Recent Developments in the Neurobiology of Dissociation. 1996, 163-190. DOI: 10.1007/978-1-4899-0310-5_8.
- Stine S, Krystal J, Kosten T, Charney D. Mazindol treatment for cocaine dependence. Drug And Alcohol Dependence 1995, 39: 245-252. PMID: 8556974, DOI: 10.1016/0376-8716(95)01174-4.
- Bremner J, Krystal J, Southwick S, Charney D. Functional neuroanatomical correlates of the effects of stress on memory. Journal Of Traumatic Stress 1995, 8: 527-553. PMID: 8564272, DOI: 10.1002/jts.2490080403.
- Bremner J, Krystal J, Southwick S, Charney D. Functional neuroanatomical correlates of the effects of stress on memory. Journal Of Traumatic Stress 1995, 8: 527-553. DOI: 10.1007/bf02102888.
- D'Souza D, Charney D, Krystal J. Glycine Site Agonists of the NMDA Receptor: A Review. CNS Neuroscience & Therapeutics 1995, 1: 227-260. DOI: 10.1111/j.1527-3458.1995.tb00285.x.
- Randall P, Bremner J, Krystal J, Nagy L, Heninger G, Nicolaou A, Charney D. Effects of the benzodiazepine antagonist flumazenil in PTSD. Biological Psychiatry 1995, 38: 319-324. PMID: 7495926, DOI: 10.1016/0006-3223(94)00306-n.
- Goddard A, Charney D, Germine M, Woods S, Heninger G, Krystal J, Goodman W, Price L. Effects of tryptophan depletion on responses to yohimbine in healthy human subjects. Biological Psychiatry 1995, 38: 74-85. PMID: 7578653, DOI: 10.1016/0006-3223(94)00223-p.
- Abi-Dargham A, Krystal J, Laruelle M, D'Souza D, Zoghbi S, Brenner L, Gil R, Sernyak M, Baldwin R, Zubal G, Hoffer P, Charney D, Innis R. Spect imaging of the benzodiazepine receptor in schizophrenics and healthy subjects. Schizophrenia Research 1995, 15: 75. DOI: 10.1016/0920-9964(95)95236-3.
- Krystal J, Karper L, Bennett A, Abi-Saab D, D'Souza C, Abi-Dargham A, Charney D. Modulating ketamine-induced thought disorder with lorazepam and haloperidol in humans. Schizophrenia Research 1995, 15: 156-157. DOI: 10.1016/0920-9964(95)95485-r.
- Bennett A, Abi-Saab D, Karper L, D'Souza D, Abi-Dargham A, Charney D, Krystal J. Ketamine impairs learning, but not procedural expression, on the wisconsin card sorting test. Schizophrenia Research 1995, 15: 108-109. DOI: 10.1016/0920-9964(95)95333-5.
- Belger A, McCarthy G, Gore J, Puce A, Constable T, Krystal J. Evaluation of frontal and parietal association cortex contributions to attention using fMRI. Schizophrenia Research 1995, 15: 76. DOI: 10.1016/0920-9964(95)95239-6.
- Karper L, Grillon C, Abi-Saab D, Morgan C, Charney D, Krystal J. The effect of ketamine on pre-pulse inhibition and attention. Schizophrenia Research 1995, 15: 180. DOI: 10.1016/0920-9964(95)95554-m.
- Krystal J, Karper L, D'Souza C, Webb E, Bennett A, Abi-Dargham A, Petrakis I, Brenner L, Morrissey K, Abi-Saab D, Charney D. Differentiating nmda dysregulation in schizophrenia and alcoholism using ketamine. Schizophrenia Research 1995, 15: 156. DOI: 10.1016/0920-9964(95)95484-q.
- D'Souza D, Morrissey K, Abi-Saab D, Damon D, Gil R, Bennett A, Krystal J. Intravenous glycine and oral d-Cycloserine effects on CSF Amino acids, plasma hormones and behavior in healthy humans: Implications for schizophrenia. Schizophrenia Research 1995, 15: 147. DOI: 10.1016/0920-9964(95)95456-j.
- McDougle C, Price L, Heninger G, Krystal J, Charney D. Noradrenergic response to acute ethanol administration in heathly subjects: comparison with intravenous yohimbine. Psychopharmacology 1995, 118: 127-135. PMID: 7617798, DOI: 10.1007/bf02245830.
- HILLBRAND M, YOUNG J, KRYSTAL J. Discontinuing Anticonvulsant Treatment of Aggression. Journal Of Neuropsychiatry 1995, 7: 116-a-117. PMID: 7711482, DOI: 10.1176/jnp.7.1.116-a.
- Krystal J, Woods S, Kosten T, Rosen M, Seibyl J, Van Dyck C, Price L, Zubal I, Hoffer P, Charney D. Opiate Dependence and Withdrawal: Preliminary Assessment Using Single Photon Emission Computerized Tomography (SPECT). The American Journal Of Drug And Alcohol Abuse 1995, 21: 47-63. PMID: 7762544, DOI: 10.3109/00952999509095229.
- Southwick S, Krystal J, Johnson D, Charney D. Neurobiology of Post-Traumatic Stress Disorder. 1995, 49-72. DOI: 10.1007/978-1-4899-1034-9_4.
- Southwick S, Krystal J, Charney D. Relationship of Panic Disorder to Posttraumatic Stress Disorder-Reply. JAMA Psychiatry 1995, 52: 77-78. DOI: 10.1001/archpsyc.1995.03950130077012.
- van Dyck C, Rosen M, Thomas H, McMahon T, Wallace E, O'Connor P, Sullivan M, Krystal J, Hoffer P, Woods S, Kosten T. SPECT regional cerebral blood flow alterations in naltrexone-precipitated withdrawal from buprenorphine. Psychiatry Research 1994, 55: 181-191. PMID: 7701033, DOI: 10.1016/0925-4927(94)90013-2.
- Salomon R, Delgado P, Licinio J, Krystal J, Heninger G, Charney D. Effects of sleep deprivation on serotonin function in depression. Biological Psychiatry 1994, 36: 840-846. PMID: 7893848, DOI: 10.1016/0006-3223(94)90595-9.
- Karper L, Bennett A, Erdos J, Krystal J. ANTIPSYCHOTICS, LITHIUM, BENZODIAZEPINES, BETA-BLOCKERS. Journal Of Offender Rehabilitation 1994, 21: 203-222. DOI: 10.1300/j076v21n03_13.
- D'SOUZA D, BENNETT A, ABI-DARGHAM A, KRYSTAL J. Precipitation of a Psychoneuromotor Syndrome by Fluoxetine in a Haloperidol-. Journal Of Clinical Psychopharmacology 1994, 14: 361-362. PMID: 7806697, DOI: 10.1097/00004714-199410000-00018.
- Southwick S, Bremner D, Krystal J, Charney D. Psychobiologic Research in Post-Traumatic Stress Disorder. Psychiatric Clinics Of North America 1994, 17: 251-264. PMID: 7937357, DOI: 10.1016/s0193-953x(18)30112-6.
- Brenner L, Karper L, Krystal J. Short-Term Use of Disulfiram With Clozapine. Journal Of Clinical Psychopharmacology 1994, 14: 213-214. PMID: 8027424, DOI: 10.1097/00004714-199406000-00016.
- D'Souza D, Gil R, Abi-Dargham A, Karper L, Abi-Saab D, Morrissey K, Brenner L, Charney D, Krystal J. Tryptophan depletion paradigm: Implications for schizophrenia. Biological Psychiatry 1994, 35: 703. DOI: 10.1016/0006-3223(94)90974-1.
- D'Souza D, Bennett A, Karper L, Gil R, Morrissey K, Abi-Saab D, Charney D, Krystal J. I.V. glycine/d-cycloserine to facilitate NMDA function in humans. Biological Psychiatry 1994, 35: 734. DOI: 10.1016/0006-3223(94)91085-5.
- Karper L, Grillon C, Lysaker P, Bell M, Charney D, Krystal J. Soft signs, attention, and startle in schizophrenia. Biological Psychiatry 1994, 35: 714. DOI: 10.1016/0006-3223(94)91014-6.
- Krystal J, Southwick S, Charney D. Alcohol Dependence May Be the Missing Link Between Posttraumatic Stress Disorder and Panic-Reply. JAMA Psychiatry 1994, 51: 430-430. DOI: 10.1001/archpsyc.1994.03950050090014.
- DOCHERTY N, EVANS I, SLEDGE W, SEIBYL J, KRYSTAL J. Affective Reactivity of Language in Schizophrenia. The Journal Of Nervous And Mental Disease 1994, 182: 98-103. PMID: 8308539, DOI: 10.1097/00005053-199402000-00006.
- D'Souza D, Krystal J. Perturbing the Organism: The Biology of Stressful Experience. The Journal Of Nervous And Mental Disease 1994, 182: 126. DOI: 10.1097/00005053-199402000-00023.
- HILLBRAND M, KRYSTAL J, SHARPE K, FOSTER H. Clinical Predictors of Self-Mutilation in Hospitalized Forensic Patients. The Journal Of Nervous And Mental Disease 1994, 182: 9-16. PMID: 8277305, DOI: 10.1097/00005053-199401000-00003.
- Krystal J, Karper L, Abi-Dargham A, Delaney R, Bremmer J, Bowers M, Charney D. Ketamine effects reduced by lorazepam in healthy humans. Schizophrenia Research 1993, 9: 241. DOI: 10.1016/0920-9964(93)90539-u.
- Krystal J, Karper L, Seibyl J, Delaney R, Bremner J, Bowers M, Charney D. Dose-related effects of the NMDA antagonist, ketamine, in healthy humans. Schizophrenia Research 1993, 9: 240-241. DOI: 10.1016/0920-9964(93)90538-t.
- Abi-Dargham A, Seibyl J, Laruelle M, Rattner Z, Zoghbi S, Baldwin R, Ponce Y, Charney D, Hoffer P, Krystal J, Innis R. Spect imaging of the benzodiazepine receptor in humans using [123I]iomazenil. Schizophrenia Research 1993, 9: 191. DOI: 10.1016/0920-9964(93)90389-z.
- Karper L, Bell M, Lysaker P, Seibyl J, Beam-Goulet J, Brenner L, Krystal J. The neurological evaluation scale (NES): Factor analysis and clinical correlates. Schizophrenia Research 1993, 9: 179. DOI: 10.1016/0920-9964(93)90354-l.
- Karper L, Freeman G, Morgan C, Grillon C, Charney D, Krystal J. Pre-pulse inhibition of the acoustic startle response and measures of attention in schizophrenic subjects. Schizophrenia Research 1993, 9: 160. DOI: 10.1016/0920-9964(93)90296-u.
- NAGY L, KRYSTAL J, CHARNEY D, MERIKANGAS K, WOODS S. Long-Term Outcome of Panic Disorder After Short-Term Imipramine and Behavioral Group Treatment. Journal Of Clinical Psychopharmacology 1993, 13: 16-24. PMID: 8098050, DOI: 10.1097/00004714-199302000-00003.
- SEIBYL J, SATEL S, ANTHONY D, SOUTHWICK S, KRYSTAL J, CHARNEY D. Effects of Cocaine on Hospital Course in Schizophrenia. The Journal Of Nervous And Mental Disease 1993, 181: 31-37. PMID: 8093475, DOI: 10.1097/00005053-199301000-00006.
- Krystal J. Stress, the Aging Brain, and the Mechanisms of Neuron Death. The Yale Journal Of Biology And Medicine 1993, 66: 109-110. PMCID: PMC2588844.
- Kosten T, Krystal J, Giller E, Frank J, Dan E. Alexithymia as a predictor of treatment response in post-traumatic stress disorder. Journal Of Traumatic Stress 1992, 5: 563-573. DOI: 10.1007/bf00979225.
- Kosten T, Krystal J, Giller E, Frank J, Dan E. Alexithymia as a predictor of treatment response in post‐traumatic stress disorder. Journal Of Traumatic Stress 1992, 5: 563-573. DOI: 10.1002/jts.2490050406.
- Krystal J, McDougle C, Woods S, Price L, Heninger G, Charney D. Dose-response relationship for oral idazoxan effects in healthy human subjects: comparison with oral yohimbine. Psychopharmacology 1992, 108: 313-319. PMID: 1355923, DOI: 10.1007/bf02245117.
- Seibyl J, Brenner L, Krystal J, Johnson R, Charney D. Mazindol and cocaine addiction in schizophrenia. Biological Psychiatry 1992, 31: 1179-1181. PMID: 1525287, DOI: 10.1016/0006-3223(92)90171-u.
- KARPER L, SEIBYL J, KRYSTAL J. Valproate Management of Psychosis in a Patient with Carbamazepine-Induced Hyponatremia. Journal Of Clinical Psychopharmacology 1992, 12: 137-138. PMID: 1573038, DOI: 10.1097/00004714-199204000-00015.
- WOODS S, NAGY L, KOLESZAR A, KRYSTAL J, HENINGER G, CHARNEY D. Controlled Trial of Alprazolam Supplementation During Imipramine Treatment of Panic Disorder. Journal Of Clinical Psychopharmacology 1992, 12: 32-38. PMID: 1552038, DOI: 10.1097/00004714-199202000-00006.
- WOODS S, NAGY L, KOLESZAR A, KRYSTAL J, HENINGER G, CHAEY D. Controlled Trial of Alprazolam Supplementation During Imipramine Treatment of Panic Disorder. Current Opinion In Cardiology 1992, 7: 32. DOI: 10.1097/00001573-199202000-00006.
- Krystal J. Invited commentary: complexities in evaluating neurobiological models for stress resistance. Journal Of Psychopharmacology 1992, 6: 12-14. PMID: 22291236, DOI: 10.1177/026988119200600105.
- Krystal J, Price L, Opsahl C, Ricaurte G, Heninger G. Chronic 3,4-Methylenedioxymethamphetamine (MDMA) Use: Effects on Mood and Neuropsychological Function? The American Journal Of Drug And Alcohol Abuse 1992, 18: 331-341. PMID: 1357957, DOI: 10.3109/00952999209026070.
- Krystal J, McDougle C, Kosten T, Price L, Aghajanian G, Charney D. Baclofen-assisted detoxification from opiates A pilot study. Journal Of Substance Use And Addiction Treatment 1992, 9: 139-142. PMID: 1324986, DOI: 10.1016/0740-5472(92)90081-x.
- Krystal J. Trauma and the Vietnam War Generation. The Yale Journal Of Biology And Medicine 1992, 65: 543-544. PMCID: PMC2589725.
- Krystal J. Novel Antipsychotic Drugs. The Yale Journal Of Biology And Medicine 1992, 65: 539-540. PMCID: PMC2589751.
- Rasmussen K, Krystal J, Aghajanian G. Excitatory amino acids and morphine withdrawal: differential effects of central and peripheral kynurenic acid administration. Psychopharmacology 1991, 105: 508-512. PMID: 1771218, DOI: 10.1007/bf02244371.
- Krystal J, Woods S, Hill C, Charney D. Characteristics of panic attack subtypes: Assessment of spontaneous panic, situational panic, sleep panic, and limited symptom attacks. Comprehensive Psychiatry 1991, 32: 474-480. PMID: 1778074, DOI: 10.1016/0010-440x(91)90026-9.
- Seibyl J, Krystal J, Price L, Woods S, D'Amico C, Heninger G, Charney D. Effects of ritanserin on the behavioral, neuroendocrine, and cardiovascular responses to meta-chlorophenylpiperazine in healthy human subjects. Psychiatry Research 1991, 38: 227-236. PMID: 1754635, DOI: 10.1016/0165-1781(91)90013-f.
- Nagy L, Krystal J, Charney D, Woods S. Follow-up Study of Patients With Panic Disorder-Reply. JAMA Psychiatry 1991, 48: 861-862. DOI: 10.1001/archpsyc.1991.01810330085018.
- Licinio J, Krystal J, Seibyl J, Altemus M, Charney D. Elevated central levels of interleukin-2 in drug-free schizophrenic patients. Schizophrenia Research 1991, 4: 372. DOI: 10.1016/0920-9964(91)90301-7.
- Krystal J, Seibyl J, Price L, Woods S, Heninger G, Charney D. MCPP effects in schizophrenic patients before and after typical and atypical neuroleptic treatment. Schizophrenia Research 1991, 4: 350. DOI: 10.1016/0920-9964(91)90266-t.
- Deutch A, Moghaddam B, Innis R, Krystal J, Aghajanian G, Bunney B, Charney D. Mechanisms of action of atypical antipsychotic drugs Implications for novel therapeutic strategies for schizophrenia. Schizophrenia Research 1991, 4: 121-156. PMID: 1674882, DOI: 10.1016/0920-9964(91)90030-u.
- Woods S, Charney D, Silver J, Krystal J, Heninger G. Behavioral, biochemical, and cardiovascular responses to the benzodiazepine receptor antagonist flumazenil in panic disorder. Psychiatry Research 1991, 36: 115-127. PMID: 1850142, DOI: 10.1016/0165-1781(91)90124-8.
- Woods S, O'malley S, Martini B, Mcdougle C, Price L, Krystal J, Hoffer P, Kosten T. Spect regional cerebral blood flow and neuropsychological testing in non-demented HIV-positive drug abusers: Preliminary results. Progress In Neuro-Psychopharmacology And Biological Psychiatry 1991, 15: 649-662. PMID: 1956993, DOI: 10.1016/0278-5846(91)90055-6.
- Charney D, Krystal J, Southwick S, Nagy L, Woods S, Heninger G. Serotonin Function in Panic and Generalized Anxiety Disorders. Psychiatric Annals 1990, 20: 593-602. DOI: 10.3928/0048-5713-19901001-11.
- CHARNEY D, WOODS S, KRYSTAL J, HENINGER G. Serotonin Function and Human Anxiety Disordersa. Annals Of The New York Academy Of Sciences 1990, 600: 558-572. PMID: 2252335, DOI: 10.1111/j.1749-6632.1990.tb16910.x.
- Rasmussen K, Beitner-Johnson D, Krystal J, Aghajanian G, Nestler E. Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates. Journal Of Neuroscience 1990, 10: 2308-2317. PMID: 2115910, PMCID: PMC6570391, DOI: 10.1523/jneurosci.10-07-02308.1990.
- Charney D, Woods S, Krystal J, Heninger G. Neurobiological Mechanisms of Human Anxiety. 1990, 3: 242-283. DOI: 10.1159/000417680.
- Price L, Krystal J, Heninger G, Ricaurte G. Second Thoughts on 3,4-Methylenedioxymethamphetamine (MDMA) Neurotoxicity-Reply. JAMA Psychiatry 1990, 47: 289-289. DOI: 10.1001/archpsyc.1990.01810150089015.
- Kosten T, Krystal J, Charney D, Price L, Morgan C, Kleber H. Opioid antagonist challenges in buprenorphine maintained patients. Drug And Alcohol Dependence 1990, 25: 73-78. PMID: 2323312, DOI: 10.1016/0376-8716(90)90144-4.
- SEIBYL J, KRYSTAL J, CHARNEY D. Marijuana (cannabis) use is anecdotally said to precipitate anxiety symptoms in patients with panic disorder. Is there any research evidence to support this? Also, can marijuana use precipitate or expose paranoia in patients with an underlying bipolar disorder? Journal Of Clinical Psychopharmacology 1990, 10: 78. PMID: 2307743, DOI: 10.1097/00004714-199002000-00033.
- Price L, Charney D, Delgado P, Goodman W, Krystal J, Woods S, Heninger G. Clinical studies of 5-HT function using I.V. l-Tryptophan. Progress In Neuro-Psychopharmacology And Biological Psychiatry 1990, 14: 459-472. PMID: 2236580, DOI: 10.1016/0278-5846(90)90002-x.
- Koster K, Woods S, Smith E, Zubal I, Krystal J, Charney D, Hoffer P. REGIONAL CEREBRAL BLOOD FLOW CHANGES IN PATIENTS WITH PANIC DISORDER. Clinical Nuclear Medicine 1989, 14: 234. DOI: 10.1097/00003072-198903000-00039.
- Woods S, Hegeman I, Krystal J, Smith E, Zubal I, Koster K, Hotfer P. EFFECTS OF VISUAL STIMULATION ON DISTRIBUTION OF TC-99M D, 1 HMPAO IN HEALTHY HUMAN SUBJECTS. Clinical Nuclear Medicine 1989, 14: 230. DOI: 10.1097/00003072-198903000-00025.
- SEIBYL J, KRYSTAL J, PRICE L, CHARNEY D. Use of Yohimbine to Counteract Nortriptyline-Induced Orthostatic Hypotension. Journal Of Clinical Psychopharmacology 1989, 9: 67-68. PMID: 2708559, DOI: 10.1097/00004714-198902000-00026.
- Krystal J, Walker M, Heninger G. Intermittent naloxone attenuates the development of physical dependence on methadone in rhesus monkeys. European Journal Of Pharmacology 1989, 160: 331-338. PMID: 2540995, DOI: 10.1016/0014-2999(89)90088-5.
- Krystal J. Psychopharmacology: The Third Generation of Progress. The Yale Journal Of Biology And Medicine 1989, 62: 554-555. PMCID: PMC2589180.
- Krystal J, Woods S, Levesque M, Heninger C, Heninger G. The effects of carbon dioxide inhalation of plasma MHPG, plasma hormones respiratory rate, and behavior in the Rhesus monkey. Life Sciences 1989, 45: 1657-1663. PMID: 2511388, DOI: 10.1016/0024-3205(89)90275-0.
- Woods S, Krystal J, Heninger G, Charney D. Effects of alprazolam and clonidine on carbon dioxide-induced increases in anxiety ratings in healthy human subjects. Life Sciences 1989, 45: 233-242. PMID: 2503670, DOI: 10.1016/0024-3205(89)90255-5.
- Krystal J, Kosten T, Southwick S, Mason J, Perry B, Giller E. Neurobiological aspects of PTSD: Review of clinical and preclinical studies. Behavior Therapy 1989, 20: 177-198. DOI: 10.1016/s0005-7894(89)80068-1.
- Krystal J. Neural Plasticity. A Lifespan Approach. The Yale Journal Of Biology And Medicine 1988, 61: 478-479. PMCID: PMC2590436.
- Krystal J. Quantitative Receptor Autoradiography. The Yale Journal Of Biology And Medicine 1987, 60: 294-295. PMCID: PMC2590106.
- Krystal J. Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and Heart. The Yale Journal Of Biology And Medicine 1987, 60: 202-202. PMCID: PMC2590308.
- Krystal H. Management of alcohol withdrawal in the critically ill patient: a selected review. Henry Ford Hospital Medical Journal 1986, 34: 293. PMID: 3583798.
- Krystal J. The Psychopharmacology of Lithium. The Yale Journal Of Biology And Medicine 1986, 59: 74-75. PMCID: PMC2590046.
- van der Kolk B, Greenberg M, Boyd H, Krystal J. Inescapable shock, neurotransmitters, and addiction to trauma: Toward a psychobiology of post traumatic stress. Biological Psychiatry 1985, 20: 314-325. PMID: 2858226, DOI: 10.1016/0006-3223(85)90061-7.
- Krystal J. Monoamine Innervation of the Cerebral Cortex. The Yale Journal Of Biology And Medicine 1985, 58: 58-59. PMCID: PMC2589842.
- Krystal J. Behavioral Pharmacology: The Current Status. The Yale Journal Of Biology And Medicine 1985, 58: 197-198. PMCID: PMC2589892.
- Krystal J. Ethopharmacology: Primate Models of Neuropsychiatric Disorders. The Yale Journal Of Biology And Medicine 1984, 57: 248-250. PMCID: PMC2589821.
- Krystal J. Anorexia Nervosa: Recent Developments in Research. The Yale Journal Of Biology And Medicine 1984, 57: 442-443. PMCID: PMC2589855.
- Krystal J. Physiology of Adrenocortical Secretion. Frontiers of Hormone Research. Volume 11. The Yale Journal Of Biology And Medicine 1984, 57: 247-247. PMCID: PMC2589820.
- Krystal J. The Natural History of Alcoholism: Causes, Patterns, and Paths to Recovery. The Yale Journal Of Biology And Medicine 1983, 56: 339-340. PMCID: PMC2589638.
- Krystal J, Arnold R. Psychopharmacology of Clonidine. The Yale Journal Of Biology And Medicine 1982, 55: 543-544. PMCID: PMC2596571.
- Krystal H. Trauma: considerations of its intensity and chronicity. International Psychiatry Clinics 1971, 8: 11-28. PMID: 5148247.
Departments and Programs
Biography
John Krystal, MD, is a leading expert in the areas of alcoholism, post-traumatic stress disorder, schizophrenia, and depression. His work links psychopharmacology, neuroimaging, molecular genetics, and computational neuroscience to study the neurobiology and treatment of these disorders. He is best known for leading the discovery of the rapid antidepressant effects of ketamine in depressed patients.
He is a member of the U.S. National Academy of Medicine. He also serves in a variety of advisory and review capacities for NIAAA, NIMH, Wellcome Trust, Brain and Behavior Research Foundation, the Broad Institute, and the Karolinska Institutet.
Dr. Krystal previously served on the National Alcohol Abuse and Alcoholism Advisory Council (NIAAA), the Department of Defense Psychological Health Advisory Committee, and the NIMH Board of Scientific Counselors (chair, 2005-2007). He has led the American College of Neuropsychopharmacology (president, 2012), and International College of Neuropsychophamacology (president, 2016-2018).
Currently, he is co-chair of the Neuroscience Forum (NeuroForum) of the National Academies of Sciences, Engineering, and Medicine, a member of the NIMH National Mental Health Advisory Council, and he edits the journal, Biological Psychiatry (impact factor: 11.982).
Titles
- Robert L. McNeil, Jr. Professor of Translational Research and Professor of Psychiatry, of Neuroscience, and of Psychology
- Co-Director, Yale Center for Clinical Investigation
- Chair, Psychiatry
- Physician-in-Chief of Psychiatry, Yale New Haven Hospital
- Director: NIAAA Center for the Translational Neuroscience of Alcoholism
- Director, Clinical Neuroscience Division, VA National Center for PTSD
Education & Training
- ResidencyYale University School of Medicine (1988)
- MDYale University (1984)
- BAUniversity of Chicago, Behavioral Sciences (1980)
Additional Information
Honors & Recognitions
- Colvin Prize for Outstanding Achievement in Mood Disorders Research: Brain and Behavior Research Foundation (2019)
- Ulf van Euler Memorial Lecturer: Karolinska Institute (2019)
- Edward H. Ahrens, Jr., Distinguished Investigator Award: Association for Clinical and Translational Science (2019)
- E.M. Jellinek Award for Alcohol Research: E.M. Jellinek Foundation (2016)
- Henri Begleiter Award for Research Excellence: Research Society on Alcoholism (2015)
- Paul Hoch Research Award: American Psychopathological Association (2014)
- Exemplary Psychiatrist Award: National Alliance on Mental Illness (2011)
- Member: U.S. National Academy of Medicine (2010)
- Jack Mendelson Award for Clinical Research: National Institute on Alcohol Abuse and Alcoholism (2010)
- Stanley Dean Award for Schizophrenia Research: American College of Psychiatry (2010)
Board Certifications
- AB of Psychiatry & Neurology, Psychiatry (1991)
Professional Service
- Neuroscience Forum, National Academies of Sciences, Engineering, and Medicine (2018 - Present): Co-Director
- International College of Neuropsychopharmacology (2016 - 2018): President
- NIMH (2016 - Present): NIMH National Mental Health Advisory Council
- American College of Neuropsychopharmacology (2011 - 2012): President
Publications
- Kraguljac N, Bruns D, Appelbaum P, Botello E, King V, Remiszewski N, Widge A, Alpert J, Carpenter L, Grzenda A, Krystal J, McDonald W, Nemeroff C. Post-Roe v Wade psychiatry: legal, clinical, and ethical challenges in psychiatry under abortion bans. The Lancet Psychiatry 2024 PMID: 38795722, DOI: 10.1016/s2215-0366(24)00096-8.
- Martinez-Magaña J, Nagamatsu S, Nunez-Rios D, Krystal J, Girgenti M, Group T, Montalvo-Ortiz J. The Prefrontal Cortex Transcriptomic Landscape of the Comorbidity Between Post-Traumatic Stress Disorder and Opioid Misuse. Biological Psychiatry 2024, 95: s69. DOI: 10.1016/j.biopsych.2024.02.169.
- Nunez-Rios D, Hurd Y, Rompala G, Nagamatsu S, Martinez-Magaña J, Krystal J, Group T, Montalvo-Ortiz J. Multi-Omics Mapping in Human Cortical Neurons Reveals Well-Known and Novel Loci of Post-Traumatic Stress Disorder. Biological Psychiatry 2024, 95: s34. DOI: 10.1016/j.biopsych.2024.02.087.
- Lee K, Ji J, Fonteneau C, Berkovitch L, Rahmati M, Pan L, Repovš G, Krystal J, Murray J, Anticevic A. Human Brain State Dynamics Reflect Individual Neuro-Phenotypes. Biological Psychiatry 2024, 95: s53. DOI: 10.1016/j.biopsych.2024.02.133.
- Moujaes F, Ji J, Rahmati M, Burt J, Schleifer C, Adkinson B, Savic A, Santamauro N, Tamayo Z, Diehl C, Kolobaric A, Flynn M, Rieser N, Fonteneau C, Camarro T, Xu J, Cho Y, Repovs G, Fineberg S, Morgan P, Seifritz E, Vollenweider F, Krystal J, Murray J, Preller K, Anticevic A. Ketamine induces multiple individually distinct whole-brain functional connectivity signatures. ELife 2024, 13: e84173. PMID: 38629811, PMCID: PMC11023699, DOI: 10.7554/elife.84173.
- Na P, Petrakis I, Krystal J, Pietrzak R. Problem Opioid Use Among US Military Veterans: Prevalence, Correlates, and Psychiatric Characteristics. Journal Of Addiction Medicine 2024 PMID: 38498625, DOI: 10.1097/adm.0000000000001286.
- Havlik J, Wahid S, Teopiz K, McIntyre R, Krystal J, Rhee T. Recent Advances in the Treatment of Treatment-Resistant Depression: A Narrative Review of Literature Published from 2018 to 2023. Current Psychiatry Reports 2024, 26: 176-213. PMID: 38386251, DOI: 10.1007/s11920-024-01494-4.
- Basu A, Yang J, Yu A, Glaeser-Khan S, Rondeau J, Feng J, Krystal J, Li Y, Kaye A. Frontal norepinephrine represents a threat prediction error under uncertainty. Biological Psychiatry 2024 PMID: 38316333, DOI: 10.1016/j.biopsych.2024.01.025.
- Chekroud A, Hawrilenko M, Loho H, Bondar J, Gueorguieva R, Hasan A, Kambeitz J, Corlett P, Koutsouleris N, Krumholz H, Krystal J, Paulus M. Illusory generalizability of clinical prediction models. Science 2024, 383: 164-167. PMID: 38207039, DOI: 10.1126/science.adg8538.
- Huggins A, Baird C, Briggs M, Laskowitz S, Hussain A, Fouda S, Haswell C, Sun D, Salminen L, Jahanshad N, Thomopoulos S, Veltman D, Frijling J, Olff M, van Zuiden M, Koch S, Nawjin L, Wang L, Zhu Y, Li G, Stein D, Ipser J, Seedat S, du Plessis S, van den Heuvel L, Suarez-Jimenez B, Zhu X, Kim Y, He X, Zilcha-Mano S, Lazarov A, Neria Y, Stevens J, Ressler K, Jovanovic T, van Rooij S, Fani N, Hudson A, Mueller S, Sierk A, Manthey A, Walter H, Daniels J, Schmahl C, Herzog J, Říha P, Rektor I, Lebois L, Kaufman M, Olson E, Baker J, Rosso I, King A, Liberzon I, Angstadt M, Davenport N, Sponheim S, Disner S, Straube T, Hofmann D, Qi R, Lu G, Baugh L, Forster G, Simons R, Simons J, Magnotta V, Fercho K, Maron-Katz A, Etkin A, Cotton A, O’Leary E, Xie H, Wang X, Quidé Y, El-Hage W, Lissek S, Berg H, Bruce S, Cisler J, Ross M, Herringa R, Grupe D, Nitschke J, Davidson R, Larson C, deRoon-Cassini T, Tomas C, Fitzgerald J, Blackford J, Olatunji B, Kremen W, Lyons M, Franz C, Gordon E, May G, Nelson S, Abdallah C, Levy I, Harpaz-Rotem I, Krystal J, Dennis E, Tate D, Cifu D, Walker W, Wilde E, Harding I, Kerestes R, Thompson P, Morey R. Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup. Molecular Psychiatry 2024, 1-13. PMID: 38195980, DOI: 10.1038/s41380-023-02352-0.
- Tamman A, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal J, Gelernter J, Montalvo-Ortiz J, Polimanti R, Pietrzak R. Correction: Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Neuropsychopharmacology 2024, 49: 764-764. PMID: 38182778, PMCID: PMC10876612, DOI: 10.1038/s41386-023-01786-y.
- Krystal J, Imeh I, Garces R, Addy N. The Biological Psychiatry Cover Art Initiative: Addressing the Underrepresentation of Black People on the Journal Cover Through a Series of Commissioned Artworks. Biological Psychiatry 2024, 95: 2. PMID: 38030306, DOI: 10.1016/j.biopsych.2023.10.010.
- Zhou H, Kember R, Deak J, Xu H, Toikumo S, Yuan K, Lind P, Farajzadeh L, Wang L, Hatoum A, Johnson J, Lee H, Mallard T, Xu J, Johnston K, Johnson E, Nielsen T, Galimberti M, Dao C, Levey D, Overstreet C, Byrne E, Gillespie N, Gordon S, Hickie I, Whitfield J, Xu K, Zhao H, Huckins L, Davis L, Sanchez-Roige S, Madden P, Heath A, Medland S, Martin N, Ge T, Smoller J, Hougaard D, Børglum A, Demontis D, Krystal J, Gaziano J, Edenberg H, Agrawal A, Justice A, Stein M, Kranzler H, Gelernter J. Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals. Nature Medicine 2023, 29: 3184-3192. PMID: 38062264, PMCID: PMC10719093, DOI: 10.1038/s41591-023-02653-5.
- Perl O, Duek O, Kulkarni K, Gordon C, Krystal J, Levy I, Harpaz-Rotem I, Schiller D. Neural patterns differentiate traumatic from sad autobiographical memories in PTSD. Nature Neuroscience 2023, 26: 2226-2236. PMID: 38036701, DOI: 10.1038/s41593-023-01483-5.
- Yang J, Huggins A, Sun D, Baird C, Haswell C, Frijling J, Olff M, van Zuiden M, Koch S, Nawijn L, Veltman D, Suarez-Jimenez B, Zhu X, Neria Y, Hudson A, Mueller S, Baker J, Lebois L, Kaufman M, Qi R, Lu G, Říha P, Rektor I, Dennis E, Ching C, Thomopoulos S, Salminen L, Jahanshad N, Thompson P, Stein D, Koopowitz S, Ipser J, Seedat S, du Plessis S, van den Heuvel L, Wang L, Zhu Y, Li G, Sierk A, Manthey A, Walter H, Daniels J, Schmahl C, Herzog J, Liberzon I, King A, Angstadt M, Davenport N, Sponheim S, Disner S, Straube T, Hofmann D, Grupe D, Nitschke J, Davidson R, Larson C, deRoon-Cassini T, Blackford J, Olatunji B, Gordon E, May G, Nelson S, Abdallah C, Levy I, Harpaz-Rotem I, Krystal J, Morey R, Sotiras A. Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods. Neuropsychopharmacology 2023, 49: 609-619. PMID: 38017161, PMCID: PMC10789873, DOI: 10.1038/s41386-023-01763-5.
- Krystal J, Kaye A, Jefferson S, Girgenti M, Wilkinson S, Sanacora G, Esterlis I. Ketamine and the neurobiology of depression: Toward next-generation rapid-acting antidepressant treatments. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2305772120. PMID: 38011560, PMCID: PMC10710048, DOI: 10.1073/pnas.2305772120.
- Ward E, Fragala M, Birse C, Hawrilenko M, Smolka C, Ambwani G, Brown M, Krystal J, Corlett P, Chekroud A. Assessing the impact of a comprehensive mental health program on frontline health service workers. PLOS ONE 2023, 18: e0294414. PMID: 37988363, PMCID: PMC10662717, DOI: 10.1371/journal.pone.0294414.
- Zhu X, Kim Y, Ravid O, He X, Suarez-Jimenez B, Zilcha-Mano S, Lazarov A, Lee S, Abdallah C, Angstadt M, Averill C, Baird C, Baugh L, Blackford J, Bomyea J, Bruce S, Bryant R, Cao Z, Choi K, Cisler J, Cotton A, Daniels J, Davenport N, Davidson R, DeBellis M, Dennis E, Densmore M, deRoon-Cassini T, Disner S, Hage W, Etkin A, Fani N, Fercho K, Fitzgerald J, Forster G, Frijling J, Geuze E, Gonenc A, Gordon E, Gruber S, Grupe D, Guenette J, Haswell C, Herringa R, Herzog J, Hofmann D, Hosseini B, Hudson A, Huggins A, Ipser J, Jahanshad N, Jia-Richards M, Jovanovic T, Kaufman M, Kennis M, King A, Kinzel P, Koch S, Koerte I, Koopowitz S, Korgaonkar M, Krystal J, Lanius R, Larson C, Lebois L, Li G, Liberzon I, Lu G, Luo Y, Magnotta V, Manthey A, Maron-Katz A, May G, McLaughlin K, Mueller S, Nawijn L, Nelson S, Neufeld R, Nitschke J, O'Leary E, Olatunji B, Olff M, Peverill M, Phan K, Qi R, Quidé Y, Rektor I, Ressler K, Riha P, Ross M, Rosso I, Salminen L, Sambrook K, Schmahl C, Shenton M, Sheridan M, Shih C, Sicorello M, Sierk A, Simmons A, Simons R, Simons J, Sponheim S, Stein M, Stein D, Stevens J, Straube T, Sun D, Théberge J, Thompson P, Thomopoulos S, van der Wee N, van der Werff S, van Erp T, van Rooij S, van Zuiden M, Varkevisser T, Veltman D, Vermeiren R, Walter H, Wang L, Wang X, Weis C, Winternitz S, Xie H, Zhu Y, Wall M, Neria Y, Morey R. Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium. NeuroImage 2023, 283: 120412. PMID: 37858907, PMCID: PMC10842116, DOI: 10.1016/j.neuroimage.2023.120412.
- Tamman A, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal J, Gelernter J, Montalvo-Ortiz J, Polimanti R, Pietrzak R. Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Neuropsychopharmacology 2023, 49: 699-708. PMID: 37848731, PMCID: PMC10876568, DOI: 10.1038/s41386-023-01747-5.
- Krystal J, Preller K, Corlett P, Anticevic A, Kaye A. Psychedelics and the Neurobiology of Meaningfulness. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 9: 462-463. PMID: 37730161, DOI: 10.1016/j.bpsc.2023.09.003.
- Na P, Zhou H, Montalvo-Ortiz J, Cabrera-Mendoza B, Petrakis I, Krystal J, Polimanti R, Gelernter J, Pietrzak R. Positive personality traits moderate persistent high alcohol consumption, determined by polygenic risk in U.S. military veterans: results from a 10-year, population-based, observational cohort study. Psychological Medicine 2023, 53: 7893-7901. PMID: 37642191, DOI: 10.1017/s003329172300199x.
- Rompala G, Nagamatsu S, Martínez-Magaña J, Nuñez-Ríos D, Wang J, Girgenti M, Krystal J, Gelernter J, Hurd Y, Montalvo-Ortiz J. Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex. Nature Communications 2023, 14: 4544. PMID: 37507366, PMCID: PMC10382503, DOI: 10.1038/s41467-023-40285-y.
- Krystal J, Kavalali E, Monteggia L. Ketamine and rapid antidepressant action: new treatments and novel synaptic signaling mechanisms. Neuropsychopharmacology 2023, 49: 41-50. PMID: 37488280, PMCID: PMC10700627, DOI: 10.1038/s41386-023-01629-w.
- Benfer N, Grunthal B, Dondanville K, Young-McCaughan S, Blankenship A, Abdallah C, Back S, Flanagan J, Foa E, Fox P, Krystal J, Marx B, McGeary D, McLean C, Pruiksma K, Resick P, Roache J, Shiroma P, Sloan D, Taylor D, Wachen J, López-Roca A, Nicholson K, Schobitz R, Schrader C, Sharrieff A, Yarvis J, Mintz J, Keane T, Peterson A, Litz B. DSM-5 Criterion-A-Based Trauma Types in Service Members and Veterans Seeking Treatment for Posttraumatic Stress Disorder. Psychological Trauma Theory Research Practice And Policy 2023 PMID: 37410416, PMCID: PMC10770283, DOI: 10.1037/tra0001537.
- Duek O, Korem N, Li Y, Kelmendi B, Amen S, Gordon C, Milne M, Krystal J, Levy I, Harpaz-Rotem I. Long term structural and functional neural changes following a single infusion of Ketamine in PTSD. Neuropsychopharmacology 2023, 48: 1648-1658. PMID: 37270621, PMCID: PMC10517133, DOI: 10.1038/s41386-023-01606-3.
- Fischer I, Nichter B, Na P, Norman S, Krystal J, Pietrzak R. Longitudinal Trends in Suicidal Thoughts and Behaviors Among US Military Veterans During the COVID-19 Pandemic. JAMA Psychiatry 2023, 80: 577-584. PMID: 37017978, PMCID: PMC10077136, DOI: 10.1001/jamapsychiatry.2023.0393.
- Kaye A, Rao M, Kwan A, Ressler K, Krystal J. A computational model for learning from repeated traumatic experiences under uncertainty. Cognitive, Affective, & Behavioral Neuroscience 2023, 23: 894-904. PMID: 37165181, DOI: 10.3758/s13415-023-01085-5.
- Abi-Dargham A, Moeller S, Ali F, DeLorenzo C, Domschke K, Horga G, Jutla A, Kotov R, Paulus M, Rubio J, Sanacora G, Veenstra-VanderWeele J, Krystal J. Candidate biomarkers in psychiatric disorders: state of the field. World Psychiatry 2023, 22: 236-262. PMID: 37159365, PMCID: PMC10168176, DOI: 10.1002/wps.21078.
- Surti T, Ranganathan M, Johannesen J, Gueorguieva R, Deaso E, Kenney J, Krystal J, D'Souza D. Randomized controlled trial of the glycine transporter 1 inhibitor PF-03463275 to enhance cognitive training and neuroplasticity in schizophrenia. Schizophrenia Research 2023, 256: 36-43. PMID: 37141764, PMCID: PMC10257994, DOI: 10.1016/j.schres.2023.04.010.
- Sarantopoulos C, Shin D, Schleifer C, Moujaes F, Adkinson B, Ji J, Kolabaric A, Flynn M, Santamauro N, Krystal J, Murray J, Repovs G, Martin W, Pittenger C, Anticevic A, Cho Y. 511. Common and Distinct Effects of Incentives on Spatial Working Memory in Schizophrenia and Obsessive-Compulsive Disorder. Biological Psychiatry 2023, 93: s300-s301. DOI: 10.1016/j.biopsych.2023.02.751.
- Driesen N, Herman P, Rowland M, Thompson G, Qiu M, He G, Criscuolo E, Fineberg S, Barron D, Helgeson L, Lacadie C, Chow R, Gueorguieva R, Straun T, Krystal J, Hyder F. 430. Calibrated fMRI Sensitive to Ketamine-Related Increases Throughout the Cortex. Biological Psychiatry 2023, 93: s268-s269. DOI: 10.1016/j.biopsych.2023.02.670.
- Rahmati M, Moujaes F, Schleifer C, Ji J, Fonteneau C, Tamayo Z, Santamauro N, Respov G, Fineberg S, Krystal J, Murray J, Cho Y, Anticevic A. 248. Effects of NMDA Receptor Antagonist Ketamine on Neural Tuning. Biological Psychiatry 2023, 93: s193-s194. DOI: 10.1016/j.biopsych.2023.02.488.
- Girgenti M, Zhang J, Skarica M, Hwang A, Xu K, Young K, Zhao H, Sestan N, Krystal J. Single Cell Genomic Analysis Reveals Cell Type-Specific Molecular Signatures in the Human PTSD Prefrontal Cortex. Biological Psychiatry 2023, 93: s11-s12. DOI: 10.1016/j.biopsych.2023.02.049.
- Shinn M, Hu A, Turner L, Noble S, Preller K, Ji J, Moujaes F, Achard S, Scheinost D, Constable R, Krystal J, Vollenweider F, Lee D, Anticevic A, Bullmore E, Murray J. Functional brain networks reflect spatial and temporal autocorrelation. Nature Neuroscience 2023, 26: 867-878. PMID: 37095399, DOI: 10.1038/s41593-023-01299-3.
- Johnson T, Davis J, Smith B, Krystal J, Sevier B, Perry L, Clayton E, Black S. 93 Empowering the Next Generation of Clinical & Translational Scientists. Journal Of Clinical And Translational Science 2023, 7: 26-26. PMCID: PMC10129482, DOI: 10.1017/cts.2023.176.
- Johnson T, Black S, Smith B, Krystal J, Sevier B, Aly F, Kumpf B, Grover K, Solod A. 183 Explaining Research to Children and Adolescents. Journal Of Clinical And Translational Science 2023, 7: 56-57. PMCID: PMC10129822, DOI: 10.1017/cts.2023.261.
- Widge A, Jordan A, Kraguljac N, Sullivan C, Wilson S, Benton T, Alpert J, Carpenter L, Krystal J, Nemeroff C, Dzirasa K. Structural Racism in Psychiatric Research Careers: Eradicating Barriers to a More Diverse Workforce. American Journal Of Psychiatry 2023, 180: 645-659. PMID: 37073513, DOI: 10.1176/appi.ajp.20220685.
- Wunderlich G, Blahova Z, Hake S, Ikezawa S, Marder S, Falkai P, Krystal J. Efficacy and Safety of Iclepertin (BI 425809) in Patients With Schizophrenia: CONNEX, A Phase III Randomized Controlled Trial Program. CNS Spectrums 2023, 28: 229-229. DOI: 10.1017/s1092852923001530.
- Havlik J, Murphy M, Gong N, Tang D, Krystal J. Characteristics of Esketamine Prescribers Among Medicare Beneficiaries in the United States, 2019-2020. JAMA Network Open 2023, 6: e2311250. PMID: 37103934, PMCID: PMC10140803, DOI: 10.1001/jamanetworkopen.2023.11250.
- Jia R, Ruderman L, Pietrzak R, Gordon C, Ehrlich D, Horvath M, Mirchandani S, DeFontes C, Southwick S, Krystal J, Harpaz-Rotem I, Levy I. Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach. Translational Psychiatry 2023, 13: 101. PMID: 36977676, PMCID: PMC10050320, DOI: 10.1038/s41398-023-02388-4.
- Na P, Montalvo-Ortiz J, Petrakis I, Krystal J, Polimanti R, Gelernter J, Pietrzak R. Trajectories of alcohol consumption in U.S. military veterans: Results from a 10-year population-based longitudinal study. Drug And Alcohol Dependence 2023, 246: 109833. PMID: 36963160, PMCID: PMC10811960, DOI: 10.1016/j.drugalcdep.2023.109833.
- Falkai P, Reuteman-Fowler C, Blahova Z, Ikezawa S, Marder S, Krystal J. Efficacy and safety of iclepertin (BI 425809) in patients with schizophrenia: CONNEX, a Phase III randomised controlled trial programme. European Psychiatry 2023, 66: s637-s637. PMCID: PMC10661489, DOI: 10.1192/j.eurpsy.2023.1325.
- Fineberg S, Choi E, Shapiro-Thompson R, Dhaliwal K, Neustadter E, Sakheim M, Null K, Trujillo-Diaz D, Rondeau J, Pittaro G, Peters J, Corlett P, Krystal J. A pilot randomized controlled trial of ketamine in Borderline Personality Disorder. Neuropsychopharmacology 2023, 48: 991-999. PMID: 36804489, PMCID: PMC10209175, DOI: 10.1038/s41386-023-01540-4.
- Núñez-Rios D, Martínez-Magaña J, Nagamatsu S, Krystal J, Martínez-González K, Giusti-Rodríguez P, Montalvo-Ortiz J. Cross-Species Convergence of Brain Transcriptomic and Epigenomic Findings in Posttraumatic Stress Disorder: A Systematic Review. Complex Psychiatry 2023, 9: 100-118. PMID: 37404872, PMCID: PMC10315001, DOI: 10.1159/000529536.
- Fischer I, Na P, Harpaz-Rotem I, Krystal J, Pietrzak R. Characterization of Mental Health in US Veterans Before, During, and 2 Years After the Onset of the COVID-19 Pandemic. JAMA Network Open 2023, 6: e230463. PMID: 36821116, PMCID: PMC9951035, DOI: 10.1001/jamanetworkopen.2023.0463.
- Nagamatsu S, Rompala G, Hurd Y, Núñez-Rios D, Montalvo-Ortiz J, Group T, Alvarez V, Benedek D, Che A, Cruz D, Davis D, Girgenti M, Hoffman E, Holtzheimer P, Huber B, Kaye A, Krystal J, Labadorf A, Keane T, Logue M, McKee A, Marx B, Mash D, Miller M, Noller C, JM-O, Scott W, Schnurr P, Stein T, Ursano R, Williamson D, Wolf E, Young K. CpH methylome analysis in human cortical neurons identifies novel gene pathways and drug targets for opioid use disorder. Frontiers In Psychiatry 2023, 13: 1078894. PMID: 36745154, PMCID: PMC9892724, DOI: 10.3389/fpsyt.2022.1078894.
- Stanley I, Marx B, Fina B, Young-McCaughan S, Tyler H, Sloan D, Blankenship A, Dondanville K, Walker J, Boffa J, Bryan C, Brown L, Straud C, Mintz J, Abdallah C, Back S, Blount T, DeBeer B, Flanagan J, Foa E, Fox P, Fredman S, Krystal J, McDevitt-Murphy M, McGeary D, Pruiksma K, Resick P, Roache J, Shiroma P, Taylor D, Wachen J, Kaplan A, López-Roca A, Nicholson K, Schobitz R, Schrader C, Sharrieff A, Yarvis J, Litz B, Keane T, Peterson A. Psychometric Properties of the Self-Injurious Thoughts and Behaviors Interview–Short Form Among U.S. Active Duty Military Service Members and Veterans. Assessment 2023, 30: 2332-2346. PMID: 36644835, DOI: 10.1177/10731911221143979.
- Reuteman-Fowler C, Blahova Z, Ikezawa S, Marder S, Falkai P, Krystal J. Efficacy and safety of iclepertin (BI 425809) in patients with schizophrenia: CONNEX, a Phase III randomised controlled trial programme. Neuroscience Applied 2023, 2: 102592. DOI: 10.1016/j.nsa.2023.102592.
- Krystal J, Kane J, Correll C, Walling D, Leoni M, Duvvuri S, Patel S, Chang I, Iredale P, Frohlich L, Versavel S, Perry P, Sanchez R, Renger J. Emraclidine, a novel positive allosteric modulator of cholinergic M4 receptors, for the treatment of schizophrenia: a two-part, randomised, double-blind, placebo-controlled, phase 1b trial. The Lancet 2022, 400: 2210-2220. PMID: 36528376, DOI: 10.1016/s0140-6736(22)01990-0.
- Nagamatsu S, Pietrzak R, Xu K, Krystal J, Gelernter J, Montalvo‐Ortiz J. Dissecting the epigenomic differences between smoking and nicotine dependence in a veteran cohort. Addiction Biology 2022, 28: e13259. PMID: 36577721, DOI: 10.1111/adb.13259.
- Nichter B, Koller D, De Angelis F, Wang J, Girgenti M, Na P, Hill M, Norman S, Krystal J, Gelernter J, Polimanti R, Pietrzak R. Genetic liability to suicidal thoughts and behaviors and risk of suicide attempt in US military veterans: moderating effects of cumulative trauma burden. Psychological Medicine 2022, 53: 6325-6333. PMID: 36444557, DOI: 10.1017/s0033291722003646.
- Merians A, Spiller T, Harpaz-Rotem I, Krystal J, Pietrzak R. Post-traumatic Stress Disorder. Medical Clinics Of North America 2022, 107: 85-99. PMID: 36402502, DOI: 10.1016/j.mcna.2022.04.003.
- Kohler C, Wolf D, Abi-Dargham A, Anticevic A, Cho Y, Fonteneau C, Gil R, Girgis R, Gray D, Grinband J, Javitch J, Kantrowitz J, Krystal J, Lieberman J, Murray J, Ranganathan M, Santamauro N, Van Snellenberg J, Tamayo Z, Group T, D'Souza D, Srihari V, Gueorguieva R, Patel P, Forselius-Bielen K, Lu J, Butler A, Fram G, Afriyie-Agyemang Y, Selloni A, Cadavid L, Gomez-Luna S, Gupta A, Radhakrishnan R, Rashid A, Aker R, Abrahim P, Nia A, Surti T, Kegeles L, Carlson M, Goldberg T, Gangwisch J, Benedict E, Govil P, Brazis S, Mayer M, de la Garrigue N, Fallon N, Baumvoll T, Abeykoon S, Perlman G, Bobchin K, Elliott M, Schmidt L, Rush S, Port A, Heffernan Z, Laney N, Kantor J, Hohing T, Gur R, Gur R, Calkins M. Illness Phase as a Key Assessment and Intervention Window for Psychosis. Biological Psychiatry Global Open Science 2022, 3: 340-350. PMID: 37519466, PMCID: PMC10382701, DOI: 10.1016/j.bpsgos.2022.05.009.
- Aljishi A, Sandhu M, Shaikh N, Wise T, Krystal J, Kaye A, Damisah E. P143. Intracranial Electrophysiology of Amygdala-Insula Interactions in Anxiety. Biological Psychiatry 2022, 91: s144-s145. DOI: 10.1016/j.biopsych.2022.02.377.
- Shaikh N, Sandhu M, Aljishi A, Obaid S, Gu B, Krystal J, Kaye A, Damisah E. P142. Neural Correlates of Bodily Feedback During Spatial Threat Avoidance. Biological Psychiatry 2022, 91: s144. DOI: 10.1016/j.biopsych.2022.02.376.
- Nunez-Rios D, Rompala G, Hurd Y, Nagamatsu S, Martinez-Magaña J, Krystal J, Gelernter J, Montalvo-Ortiz T. P630. Multiomics Mapping of Posttraumatic Stress Disorder in Human Cortical Neurons. Biological Psychiatry 2022, 91: s344. DOI: 10.1016/j.biopsych.2022.02.867.
- Nagamatsu S, Pietrzak R, Na P, Krystal J, Gelernter J, Montalvo-Ortiz J. P79. Are Positive Psychosocial Traits Linked to Epigenetic Aging? Results From a National Sample of U.S. Military Veterans. Biological Psychiatry 2022, 91: s119. DOI: 10.1016/j.biopsych.2022.02.313.
- Swanberg K, Prinsen H, Averill C, Campos L, Kurada A, Krystal J, Petrakis I, Averill L, Abdallah C, Juchem C. Abnormal glutamate metabolism in prefrontal cortex of post-traumatic stress disorder linked to comorbidity with major depression. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2022 DOI: 10.58530/2022/3344.
- Bonomi R, Girgenti M, Krystal J, Cosgrove K. A Role for Histone Deacetylases in the Biology and Treatment of Post-Traumatic Stress Disorder: What Do We Know and Where Do We Go from Here? Complex Psychiatry 2022, 8: 13-27. PMID: 36545044, PMCID: PMC9669946, DOI: 10.1159/000524079.
- Pathak GA, Singh K, Wendt FR, Fleming TW, Overstreet C, Koller D, Tylee DS, De Angelis F, Cabrera Mendoza B, Levey DF, Koenen KC, Krystal JH, Pietrzak RH, O’ Donell C, Gaziano JM, Falcone G, Stein MB, Gelernter J, Pasaniuc B, Mancuso N, Davis LK, Polimanti R. Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits. Molecular Psychiatry 2022, 27: 1394-1404. PMID: 35241783, PMCID: PMC9210390, DOI: 10.1038/s41380-022-01488-9.
- Montalvo-Ortiz JL, Gelernter J, Cheng Z, Girgenti MJ, Xu K, Zhang X, Gopalan S, Zhou H, Duman RS, Southwick SM, Krystal JH, Pietrzak R. Epigenome-wide association study of posttraumatic stress disorder identifies novel loci in U.S. military veterans. Translational Psychiatry 2022, 12: 65. PMID: 35177594, PMCID: PMC8854688, DOI: 10.1038/s41398-022-01822-3.
- Krystal J. Edward F. Domino, Ph.D. (1924–2021). Neuropsychopharmacology 2022, 47: 1138-1139. PMCID: PMC8938419, DOI: 10.1038/s41386-022-01280-x.
- Barron D, Heisig S, Agurto C, Norel R, Quagan B, Powers A, Birnbaum M, Constable T, Cecchi G, Krystal J. Feasibility Analysis of Phenotype Quantification from Unstructured Clinical Interactions. Computational Psychiatry 2022, 6: 1. PMID: 38774775, PMCID: PMC11104416, DOI: 10.5334/cpsy.78.
- Wunderlich G, Blahova Z, Hake S, Ikezawa S, Marder S, Falkai P, Krystal J. Efficacy and safety of BI 425809 in patients with schizophrenia: CONNEX, a Phase III randomised controlled trial programme. Neuroscience Applied 2022, 1: 100342. DOI: 10.1016/j.nsa.2022.100342.
- Na PJ, De Angelis F, Nichter B, Wendt FR, Krystal JH, Southwick SM, Levey DF, Gelernter J, Polimanti R, Pietrzak RH. Psychosocial moderators of polygenic risk for suicidal ideation: Results from a 7-year population-based, prospective cohort study of U.S. veterans. Molecular Psychiatry 2021, 27: 1068-1074. PMID: 34725455, DOI: 10.1038/s41380-021-01352-2.
- Krystal J. Potential Schizophrenia Medications Point to New Disease Model. Psychiatric News 2021, 56 DOI: 10.1176/appi.pn.2021.11.37.
- Thompson SL, Gianessi CA, O'Malley SS, Cavallo DA, Shi JM, Tetrault JM, DeMartini KS, Gueorguieva R, Pittman B, Krystal JH, Taylor JR, Krishnan-Sarin S. Saracatinib Fails to Reduce Alcohol-Seeking and Consumption in Mice and Human Participants. Frontiers In Psychiatry 2021, 12: 709559. PMID: 34531767, PMCID: PMC8438169, DOI: 10.3389/fpsyt.2021.709559.
- Beck K, Hindley G, Borgan F, Ginestet C, McCutcheon R, Brugger S, Driesen N, Ranganathan M, D'Souza D, Taylor M, Krystal J, Howes O. The effect of ketamine on psychopathology and implications for understanding schizophrenia and its therapeutic use: a meta-analysis. BJPsych Open 2021, 7: s237-s237. PMCID: PMC8771247, DOI: 10.1192/bjo.2021.634.
- Girgenti M, Skarica M, Zhang J, Wang J, Friedman M, Zhao H, Krystal J. Integrative Functional Genomic Analysis of Human PTSD Molecular Pathology and Risk. Biological Psychiatry 2021, 89: s12. DOI: 10.1016/j.biopsych.2021.02.050.
- McClurkin M, Krystal J, Kaye A, Damisah E. Human iEEG Characterization of Threat and Anxiety Oscillations Across Amygdala, Hippocampus, and Frontal Cortex. Biological Psychiatry 2021, 89: s255. DOI: 10.1016/j.biopsych.2021.02.638.
- Barron D, Heisig S, Agurto C, Norel R, Quagan B, Powers A, Baker J, Constable T, Cecchi G, Krystal J. Preliminary Evaluation of Phenotypic Features from Clinical Interactions. Journal Of Pain 2021, 22: 594. DOI: 10.1016/j.jpain.2021.03.068.
- Wendt FR, Pathak GA, Levey DF, Nuñez YZ, Overstreet C, Tyrrell C, Adhikari K, De Angelis F, Tylee DS, Goswami A, Krystal JH, Abdallah CG, Stein MB, Kranzler HR, Gelernter J, Polimanti R. Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality. Neurobiology Of Stress 2021, 14: 100309. PMID: 33665242, PMCID: PMC7905234, DOI: 10.1016/j.ynstr.2021.100309.
- Girgenti MJ, Wang J, Ji D, Cruz DA, Stein M, Gelernter J, Young K, Huber B, Williamson D, Friedman M, Krystal J, Zhao H, Duman R. Transcriptomic organization of the human brain in post-traumatic stress disorder. Nature Neuroscience 2020, 24: 24-33. PMID: 33349712, DOI: 10.1038/s41593-020-00748-7.
- Krystal JH, Alvarado J, Ball SA, Fortunati FG, Hu M, Ivy ME, Kapo J, Olson KD, Rohrbaugh RM, Sinha R, Tebes JK, Vender RJ, Yonkers KA, Mayes LC. Mobilizing an institutional supportive response for healthcare workers and other staff in the context of COVID-19: The Yale experience. General Hospital Psychiatry 2020, 68: 12-18. PMID: 33254081, PMCID: PMC7680059, DOI: 10.1016/j.genhosppsych.2020.11.005.
- Moujaes F, Preller K, Vollenweider F, Schleifer C, Adkinson B, Kolobaric A, Fineberg S, Krystal J, Repovs G, Santamauro N, Morgan P, Savic A, Cho Y, D. M, Anticevic A. P.499 Ketamine's influence on global resting-state functional connectivity and individual variation in neuro-behavioural relationships. European Neuropsychopharmacology 2020, 40: s278-s279. DOI: 10.1016/j.euroneuro.2020.09.363.
- Krystal J. Robert T. Malison, M.D. (1959–2020). Neuropsychopharmacology 2020, 45: 2133-2134. PMCID: PMC7547671, DOI: 10.1038/s41386-020-00817-2.
- Bhatt S, Hillmer AT, Girgenti MJ, Rusowicz A, Kapinos M, Nabulsi N, Huang Y, Matuskey D, Angarita GA, Esterlis I, Davis MT, Southwick SM, Friedman MJ, Duman R, Carson R, Krystal J, Pietrzak R, Cosgrove K. PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies. Nature Communications 2020, 11: 2360. PMID: 32398677, PMCID: PMC7217830, DOI: 10.1038/s41467-020-15930-5.
- Girgenti M, Wang J, Ji D, Cruz D, Group T, Program M, Stein M, Gelernter J, Young K, Huber B, Williamson D, Friedman M, Krystal J, Zhao H, Duman R. Transcriptomic Organization of Human Posttraumatic Stress Disorder. Biological Psychiatry 2020, 87: s122. DOI: 10.1016/j.biopsych.2020.02.330.
- Stone L, Girgenti M, Krystal J, Duman R, Group T. Neural Transcriptomic Alterations Associated With Neuropeptide Y and Ghrelin in Posttraumatic Stress Disorder. Biological Psychiatry 2020, 87: s421-s422. DOI: 10.1016/j.biopsych.2020.02.1075.
- Nemati S, Akiki T, Ju Y, Averill C, Fouda S, Dutta A, Mckie S, Krystal J, Deakin B, Averill L, Abdallah C. A Shift in Executive Connectivity Predates and Predicts Response to Treatment in Major Depressive Disorder. Biological Psychiatry 2020, 87: s107. DOI: 10.1016/j.biopsych.2020.02.294.
- Barron D, Heisig S, Norel R, Agurto C, Quagan B, Powers A, Baker J, Constable R, Cecchi G, Krystal J. Preliminary Phenotypic Feature Capture During Clinical Interaction. Biological Psychiatry 2020, 87: s212-s213. DOI: 10.1016/j.biopsych.2020.02.552.
- Barron D, Bzdok D, Krystal J, Constable R. What Can Machine Learning Do for Psychiatry? Biological Psychiatry 2020, 87: s462. DOI: 10.1016/j.biopsych.2020.02.1176.
- Wendt F, Pathak G, Lencz T, Krystal J, Gelernter J, Polimanti R. Education and Socioeconomic Status Mask the Identification of Brain Cell Types in GWAS of Mental Health and Disease. Biological Psychiatry 2020, 87: s110. DOI: 10.1016/j.biopsych.2020.02.302.
- Koblan KS, Kent J, Hopkins SC, Krystal JH, Cheng H, Goldman R, Loebel A. A Non–D2-Receptor-Binding Drug for the Treatment of Schizophrenia. New England Journal Of Medicine 2020, 382: 1497-1506. PMID: 32294346, DOI: 10.1056/nejmoa1911772.
- Nestler E, Krystal J. Ronald S. Duman (1954–2020). Neuron 2020, 105: 769-770. DOI: 10.1016/j.neuron.2020.02.018.
- Abdallah CG, Averill LA, Gueorguieva R, Goktas S, Purohit P, Ranganathan M, Sherif M, Ahn KH, D’Souza D, Formica R, Southwick SM, Duman RS, Sanacora G, Krystal JH. Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin. Neuropsychopharmacology 2020, 45: 990-997. PMID: 32092760, PMCID: PMC7162891, DOI: 10.1038/s41386-020-0644-9.
- Krystal J, Nestler E, Picciotto M. Ronald S. Duman, Ph.D. (1954–2020). Neuropsychopharmacology 2020, 45: 1078-1078. PMCID: PMC7162938, DOI: 10.1038/s41386-020-0642-y.
- Krishnan-Sarin S, O’Malley S, Franco N, Cavallo DA, Tetrault JM, Shi J, Gueorguieva R, Pittman B, Krystal JH. Influence of combined treatment with naltrexone and memantine on alcohol drinking behaviors: a phase II randomized crossover trial. Neuropsychopharmacology 2019, 45: 319-326. PMID: 31590179, PMCID: PMC6901445, DOI: 10.1038/s41386-019-0536-z.
- Averill LA, Abdallah CG, Levey DF, Han S, Harpaz‐Rotem I, Kranzler HR, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study. Depression And Anxiety 2019, 36: 834-845. PMID: 31385647, DOI: 10.1002/da.22912.
- Davis MT, Hillmer A, Holmes SE, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Angarita G, Carson RE, Krystal JH, Esterlis I. In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 11490-11495. PMID: 31085640, PMCID: PMC6561298, DOI: 10.1073/pnas.1818871116.
- Cho Y, Schleifer C, Moujaes F, Starc M, Ji J, Santamauro N, Adkinson B, Kolobaric A, Flynn M, Krystal J, Murray J, Repovs G, Anticevic A. T193. Monetary Incentives Shape Behavioral and Neural Precision of Spatial Working Memory. Biological Psychiatry 2019, 85: s204-s205. DOI: 10.1016/j.biopsych.2019.03.516.
- Barron D, Gao S, Greene A, Constable R, Krystal J, Scheinost D. S179. Transdiagnostic Prediction of Memory and Executive Function From Whole-Brain Functional Connectivity. Biological Psychiatry 2019, 85: s366-s367. DOI: 10.1016/j.biopsych.2019.03.930.
- Moujaes F, Preller K, Vollenweider F, Schleifer C, Ji J, Adkinson B, Kolobaric A, Flynn M, Fineberg S, Krystal J, Repovs G, Santamauro N, Morgan P, Savic A, Cho Y, Murray J, Anticevic A. S159. NMDA Receptor Antagonism Effects on Delayed Spatial Working Memory and Distraction in Comparison With Schizophrenia. Biological Psychiatry 2019, 85: s358. DOI: 10.1016/j.biopsych.2019.03.910.
- Burt J, Preller K, Demirtas M, Ji J, Krystal J, Vollenweider F, Anticevic A, Murray J. S175. Large-Scale Model of Human Cortex Captures LSD-Induced Functional Alterations via HTR2A-Mediated Neural Gain Modulation. Biological Psychiatry 2019, 85: s365. DOI: 10.1016/j.biopsych.2019.03.926.
- Moujaes F, Schleifer C, Ji L, Adkinson B, Kolobaric A, Flynn M, Fineberg S, Krystal J, Repovs G, Cho Y, Santamauro N, Morgan P, Savic A, Murray J, Anticevic A. F195. NMDAR Antagonism via Ketamine Differentially Modulates Thalamic Versus Hippocampal Brain-Wide Functional Connectivity. Biological Psychiatry 2019, 85: s289. DOI: 10.1016/j.biopsych.2019.03.732.
- Hamilton H, Ford J, Roach B, Gunduz-Bruce H, Krystal J, Jaeger J, Reinhart R, Mathalon D. T161. Effects of Ketamine Administration on the P300 Event-Related Potential: Implications for Schizophrenia. Biological Psychiatry 2019, 85: s191. DOI: 10.1016/j.biopsych.2019.03.484.
- Kolobaric A, Anticevic A, Hu X, Xiao Y, Hu J, Li F, Bi F, Cole M, Savic A, Yang G, Repovs G, Murray J, Wang X, Huang X, Lui S, Krystal J, Gong Q. T174. Examining the Neurobiological Progression of Early Course Schizophrenia. Biological Psychiatry 2019, 85: s196-s197. DOI: 10.1016/j.biopsych.2019.03.497.
- Kaye A, Ressler K, Krystal J. S16. PTSD as a Threat Mood: Insights From a Reinforcement Learning Model. Biological Psychiatry 2019, 85: s302. DOI: 10.1016/j.biopsych.2019.03.767.
- Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Lower synaptic density is associated with depression severity and network alterations. Nature Communications 2019, 10: 1529. PMID: 30948709, PMCID: PMC6449365, DOI: 10.1038/s41467-019-09562-7.
- Duman RS, Sanacora G, Krystal JH. Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments. Neuron 2019, 102: 75-90. PMID: 30946828, PMCID: PMC6450409, DOI: 10.1016/j.neuron.2019.03.013.
- Krystal JH, Abdallah CG, Sanacora G, Charney DS, Duman RS. Ketamine: A Paradigm Shift for Depression Research and Treatment. Neuron 2019, 101: 774-778. PMID: 30844397, PMCID: PMC6560624, DOI: 10.1016/j.neuron.2019.02.005.
- Homan P, Levy I, Feltham E, Gordon C, Hu J, Li J, Pietrzak RH, Southwick S, Krystal JH, Harpaz-Rotem I, Schiller D. Neural computations of threat in the aftermath of combat trauma. Nature Neuroscience 2019, 22: 470-476. PMID: 30664770, PMCID: PMC6829910, DOI: 10.1038/s41593-018-0315-x.
- Preller KH, Burt JB, Ji JL, Schleifer CH, Adkinson BD, Stämpfli P, Seifritz E, Repovs G, Krystal JH, Murray JD, Vollenweider FX, Anticevic A. Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor. ELife 2018, 7: e35082. PMID: 30355445, PMCID: PMC6202055, DOI: 10.7554/elife.35082.
- Zhornitsky S, Ide J, Wang W, Chao H, Zhang S, Hu S, Krystal J, Li C. Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult Drinkers. Brain Connectivity 2018, 8: 487-502. PMID: 30198312, PMCID: PMC6207153, DOI: 10.1089/brain.2018.0633.
- Zhou H, Cheng Z, Bass N, Krystal JH, Farrer LA, Kranzler HR, Gelernter J. Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression. Translational Psychiatry 2018, 8: 208. PMID: 30287806, PMCID: PMC6172277, DOI: 10.1038/s41398-018-0258-8.
- Abdallah CG, De Feyter HM, Averill LA, Jiang L, Averill CL, Chowdhury GMI, Purohit P, de Graaf RA, Esterlis I, Juchem C, Pittman BP, Krystal JH, Rothman DL, Sanacora G, Mason GF. The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects. Neuropsychopharmacology 2018, 43: 2154-2160. PMID: 29977074, PMCID: PMC6098048, DOI: 10.1038/s41386-018-0136-3.
- Zhang X, Zhang X, Hu Y, Justice A, Li B, Wang Z, Zhao H, Krystal J, Xu K. DNA methylation signatures analysis with Illumina Infinitum MethylationEPIC and Infinium Human Methylation 450K BeadChip. Protocol Exchange 2018 DOI: 10.1038/protex.2018.080.
- Wilkinson S, Ostroff R, Katz R, Krystal J. Erratum to: Ketamine: A Promising Rapid-Acting Antidepressant. 2018, e1-e1. DOI: 10.1007/978-981-10-6577-4_24.
- Zhou H, Zhong Z, Bass N, Krystal J, Farrer L, Kranzler H, Gelernter J. F131. Genome-Wide Association Study Identifies Glutamate Ionotropic Receptor GRIA4 as a Risk Gene for Comorbid Nicotine Dependence and Major Depression. Biological Psychiatry 2018, 83: s288-s289. DOI: 10.1016/j.biopsych.2018.02.744.
- Cho Y, Schleifer C, Moujaes F, Starc M, Ji J, Santamauro N, Adkinson B, Lituchy M, Krystal J, Murray J, Repovs G, Anticevic A. S232. Effects of Incentive Presentation on Spatial Working Memory Performance. Biological Psychiatry 2018, 83: s438. DOI: 10.1016/j.biopsych.2018.02.1124.
- Girgenti M, Cruz D, Williamson D, Friedman M, Krystal J, Duman R. T103. Transcriptome Alterations for Posttraumatic Stress Disorder in Human Prefrontal Cortex. Biological Psychiatry 2018, 83: s168. DOI: 10.1016/j.biopsych.2018.02.439.
- Krystal J. 2. MICROCIRCUITS, MACROCIRCUITS, AND CORTICOL DYSFUNCTION IN SCHIZOPHRENIA: A COMPUTATIONAL AND TRANSLATIONAL NEUROSCIENCE PERSPECTIVE. Schizophrenia Bulletin 2018, 44: s1-s1. PMCID: PMC5887654, DOI: 10.1093/schbul/sby014.001.
- Anticevic A, Krystal J, Murray J. Meeting Emerging Challenges and Opportunities in Psychiatry Through Computational Neuroscience. 2018, xiii-xxxi. DOI: 10.1016/b978-0-12-809825-7.02004-6.
- Zhang X, Zhang X, Hu Y, Justice A, Li B, Wang Z, Zhao H, Krystal J, Xu K. DNA methylation signatures analysis with Illumina Infinitum MethylationEPIC and Infinium Human Methylation 450K BeadChip. Protocol Exchange 2017 DOI: 10.1038/protex.2017.135.
- Andersen AM, Pietrzak RH, Kranzler HR, Ma L, Zhou H, Liu X, Kramer J, Kuperman S, Edenberg HJ, Nurnberger JI, Rice JP, Tischfield JA, Goate A, Foroud TM, Meyers JL, Porjesz B, Dick DM, Hesselbrock V, Boerwinkle E, Southwick SM, Krystal JH, Weissman MM, Levinson DF, Potash JB, Gelernter J, Han S. Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence. JAMA Psychiatry 2017, 74: 1153-1160. PMID: 28813562, PMCID: PMC5710224, DOI: 10.1001/jamapsychiatry.2017.2269.
- Wilkinson S, Ostroff R, Katz R, Krystal J. Ketamine: A Promising Rapid-Acting Antidepressant. 2017, 223-239. DOI: 10.1007/978-981-10-6577-4_16.
- Krystal J. My Path to Psychiatry. Psychiatric News 2017, 52: 1-1. DOI: 10.1176/appi.pn.2017.10b1.
- Krystal J. KL.01.01 Targeting glutamate in psychiatric disease. European Neuropsychopharmacology 2017, 27: s521. DOI: 10.1016/s0924-977x(17)30985-9.
- Holmes SE, Girgenti MJ, Davis MT, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Duman RS, Carson RE, Krystal JH, Esterlis I, Friedman M, Kowall N, Brady C, McKee A, Stein T, Huber B, Kaloupek D, Alvarez V, Benedek D, Ursano R, Williamson D, Cruz D, Young K, Duman R, Krystal J, Mash D, Hardegree M, Serlin G. Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 8390-8395. PMID: 28716937, PMCID: PMC5547601, DOI: 10.1073/pnas.1701749114.
- Cortes-Briones J, Skosnik P, D’Souza D, Abdallah C, Petrakis I, Krystal J. 67 Ketamine-induced Changes in Neural Noise and their Relationship to Psychosis-like Symptoms. Biological Psychiatry 2017, 81: s28. DOI: 10.1016/j.biopsych.2017.02.078.
- Cho Y, Schleifer C, Starc M, Ji J, Santamauro N, Adkinson B, Lituchy M, Krystal J, Murray J, Repovs G, Anticevic A. 961 Incentives to Perform: The Effects of Reward on Working Memory. Biological Psychiatry 2017, 81: s389. DOI: 10.1016/j.biopsych.2017.02.687.
- Preller K, Schleifer C, Stämpfli P, Krystal J, Vollenweider F, Anticevic A. 951 Changes in Resting-State Global Brain Connectivity in LSD-Induced Altered States of Consciousness are Attributable to the 5-HT2A Receptor. Biological Psychiatry 2017, 81: s385. DOI: 10.1016/j.biopsych.2017.02.677.
- Davis M, Holmes S, Pietrzak R, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Carson R, Krystal J, Esterlis I. 18 In Vivo Quantification of mGluR5 Availability in Posttraumatic Stress Disorder. Biological Psychiatry 2017, 81: s8. DOI: 10.1016/j.biopsych.2017.02.029.
- Esterlis I, Pietrzak R, DellaGioia N, Matuskey D, Huang H, Krystal J, Duman R, Carson R, Finnema S. 389 In Vivo Evidence of Lower Synaptic Density in Depression and Associated Mood and Cognitive Deficits: A [11C]UCB-J PET Imaging Study. Biological Psychiatry 2017, 81: s159. DOI: 10.1016/j.biopsych.2017.02.406.
- Anticevic A, Schleifer C, Srihari V, Krystal J, Murray J, Repovs G, Xu G, Ji L, Cho Y, Santamauro N, Foss-Feig J, Yang G, Morgan P, Savic A. 423 NMDAR Antagonism via Ketamine Differentially Modulates Thalamic versus Hippocampal Functional Connectivity. Biological Psychiatry 2017, 81: s172-s173. DOI: 10.1016/j.biopsych.2017.02.907.
- Hamilton H, Kort N, Ford J, Roach B, Gunduz-Bruce H, Krystal J, Jaeger J, Reinhart R, Mathalon D. 540 Effects of N-methyl-D-aspartate Glutamate Receptor Disruption and Nicotinic Acetylcholine Enhancement on Mismatch Negativity. Biological Psychiatry 2017, 81: s219. DOI: 10.1016/j.biopsych.2017.02.1148.
- Akiki T, Averill C, Wrocklage K, Scott J, Alexander-Bloch A, Southwick S, Krystal J, Abdallah C. 581 The Default Mode Network in Posttraumatic Stress Disorder (PTSD): A Data-Driven Multimodal Approach. Biological Psychiatry 2017, 81: s235. DOI: 10.1016/j.biopsych.2017.02.451.
- Ferri J, Ford J, Roach B, Perry-O׳Leary D, Jaeger J, Gunduz-Bruce H, Krystal J, Mathalon D. 539 Ketamine, an NMDA-Receptor Antagonist, Mimics the Patterns of Intrinsically but Not Extrinsically Driven Gamma Oscillations. Biological Psychiatry 2017, 81: s218-s219. DOI: 10.1016/j.biopsych.2017.02.1147.
- Morey R, Logue M, van Rooij S, Dennis E, Davis S, Hayes J, Stevens J, Densmore M, Koch S, Korgaonkar M, LeBois L, Peverill M, Jahanshad N, Lagopoulos J, Gueze E, Jovanovic T, Abdallah C, Bennett M, King A, Krystal J, Bryant R, Miller M, Veltman D, McLaughlin K, Lanius R, Stein D, Thomaes K, Liberzon I, Ressler K, Thompson P. 87 Volume of Sub-Cortical Structures in Posttraumatic Stress Disorder from Multi-Site Investigation by ENIGMA and PGC Consortia. Biological Psychiatry 2017, 81: s36-s37. DOI: 10.1016/j.biopsych.2017.02.099.
- Krystal J, Anticevic A, Murray J, Glahn D, Driesen N, Yang G, Wang X. Clinical Heterogeneity Arising from Categorical and Dimensional Features of the Neurobiology of Psychiatric Diagnoses: Insights from Neuroimaging and Computational Neuroscience. 2016, 293-316. DOI: 10.7551/mitpress/10936.003.0023.
- Knickman J, Krishnan K, Pincus H, Blanco C, Blazer D, Coye M, Krystal J, Rauch S, Simon G, Vitiello B. Improving Access to Effective Care for People Who Have Mental Health and Substance Use Disorders: A Vital Direction for Health and Health Care. NAM Perspectives 2016, 6 DOI: 10.31478/201609v.
- Krystal J, Sanacora G, Abdallah C, Duman R. Speaker 4: John Krystal, USA. The International Journal Of Neuropsychopharmacology 2016, 19: 19-19. PMCID: PMC5616528, DOI: 10.1093/ijnp/pyw042.052.
- Duman RS, Aghajanian GK, Sanacora G, Krystal JH. Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nature Medicine 2016, 22: 238-249. PMID: 26937618, PMCID: PMC5405628, DOI: 10.1038/nm.4050.
- Yang GJ, Murray JD, Wang XJ, Glahn DC, Pearlson GD, Repovs G, Krystal JH, Anticevic A. Functional hierarchy underlies preferential connectivity disturbances in schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 113: e219-e228. PMID: 26699491, PMCID: PMC4720350, DOI: 10.1073/pnas.1508436113.
- Abdallah C, Krystal J. Ketamine. 2015, 857-862. DOI: 10.1007/978-3-642-36172-2_7031.
- Cosgrove KP, McKay R, Esterlis I, Kloczynski T, Perkins E, Bois F, Pittman B, Lancaster J, Glahn DC, O’Malley S, Carson RE, Krystal JH. Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 18031-18036. PMID: 25453062, PMCID: PMC4273348, DOI: 10.1073/pnas.1413947111.
- Wang XJ, Krystal JH. Computational Psychiatry. Neuron 2014, 84: 638-654. PMID: 25442941, PMCID: PMC4255477, DOI: 10.1016/j.neuron.2014.10.018.
- Baldan L, Williams K, Gallezot J, Pogorelov V, Rapanelli M, Crowley M, Anderson G, Loring E, Gorczyca R, Billingslea E, Wasylink S, Panza K, Ercan-Sencicek A, Krusong K, Leventhal B, Ohtsu H, Bloch M, Hughes Z, Krystal J, Mayes L, de Araujo I, Ding Y, State M, Pittenger C. Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice. Neuron 2014, 82: 1186-1187. DOI: 10.1016/j.neuron.2014.05.023.
- Abdallah C, Krystal J. Ketamine. 2014, 1-6. DOI: 10.1007/978-3-642-27772-6_7031-1.
- Rosenheck R, Leatherman S, Krystal J, Liang M. Poster #T200 SUBGROUP ANALYSIS IN A RANDOMIZED CLINICAL TRIAL OF LONG-ACTING INJECTABLE RISPERIDONE AND ORAL ANTIPSYCHOTICS IN UNSTABLE CHRONIC SCHIZOPHRENIA. Schizophrenia Research 2014, 153: s360. DOI: 10.1016/s0920-9964(14)71016-3.
- Anticevic A, Murray J, Repovs G, Starc M, Santamauro N, Savic A, Morgan P, Wang X, Krystal J. 5:45 PM INTEGRATING PHARMACOLOGY AND COMPUTATION: TOWARDS UNDERSTANDING MECHANISMS OF COGNITIVE AND CONNECTIVITY DEFICITS IN SCHIZOPHRENIA. Schizophrenia Research 2014, 153: s52-s53. DOI: 10.1016/s0920-9964(14)70172-0.
- Krystal JH, State MW. Psychiatric Disorders: Diagnosis to Therapy. Cell 2014, 157: 201-214. PMID: 24679536, PMCID: PMC4104191, DOI: 10.1016/j.cell.2014.02.042.
- Krystal J. S.19.04 Glutamatergic contributions to reward dysfunction in alcohol dependence. European Neuropsychopharmacology 2013, 23: s141. DOI: 10.1016/s0924-977x(13)70198-6.
- Krystal J. Pl.2 - KETAMINE. Behavioural Pharmacology 2013, 24: e1. DOI: 10.1097/01.fbp.0000434680.00108.7d.
- Jiang L, Gulanski BI, De Feyter HM, Weinzimer SA, Pittman B, Guidone E, Koretski J, Harman S, Petrakis IL, Krystal JH, Mason GF. Increased brain uptake and oxidation of acetate in heavy drinkers. Journal Of Clinical Investigation 2013, 123: 1605-1614. PMID: 23478412, PMCID: PMC3613911, DOI: 10.1172/jci65153.
- Anticevic A, Krystal J, Barch D. Translational cognitive neuroscience of schizophrenia: bridging neurocognitive and computational approaches toward understanding cognitive deficits. 2013, 193-230. DOI: 10.1017/cbo9781139003872.013.
- Anticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ, Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH, Corlett PR. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16720-16725. PMID: 23012427, PMCID: PMC3478611, DOI: 10.1073/pnas.1208494109.
- Stone J, Dietrich C, Edden R, Mehta M, De Simoni S, Reed L, Krystal J, Nutt D, Barker G. P.3.001 Ketamine-induced changes in anterior cingulate glutamate levels correlate with positive symptom generation. European Neuropsychopharmacology 2012, 22: s52-s53. DOI: 10.1016/s0924-977x(12)70054-8.
- Zuo L, Gelernter J, Zhang C, Zhao H, Lu L, Kranzler H, Malison R, Li C, Wang F, Zhang X, Deng H, Krystal J, Zhang F, Luo X. Erratum: Genome-Wide Association Study of Alcohol Dependence Implicates KIAA0040 on Chromosome 1q. Neuropsychopharmacology 2011, 37: 581-582. PMCID: PMC3242324, DOI: 10.1038/npp.2011.271.
- Kaffman A, Krystal J. Erratum: New Frontiers in Animal Research of Psychiatric Illness. 2011, 829: e1-e1. DOI: 10.1007/978-1-61779-458-2_38.
- Kaffman A, Krystal J. New Frontiers in Animal Research of Psychiatric Illness. 2011, 829: 3-30. PMID: 22231804, PMCID: PMC3337084, DOI: 10.1007/978-1-61779-458-2_1.
- Krystal JH, Rosenheck RA, Cramer JA, Vessicchio JC, Jones KM, Vertrees JE, Horney RA, Huang GD, Stock C, Group F. Adjunctive Risperidone Treatment for Antidepressant-Resistant Symptoms of Chronic Military Service–Related PTSD: A Randomized Trial. JAMA 2011, 306: 493-502. PMID: 21813427, DOI: 10.1001/jama.2011.1080.
- Krystal J. Biological Psychiatry: A Time of Opportunity, a Time of Challenge. Biological Psychiatry 2011, 70: 3-4. DOI: 10.1016/j.biopsych.2011.04.020.
- Krystal J, Petrakis I, Limoncelli D, Nappi S, Trevisan L, Pittman B, D'Souza D. Erratum: Characterization of the Interactive Effects of Glycine and D-Cycloserine in Men: Further Evidence for Enhanced NMDA Receptor Function Associated with Human Alcohol Dependence. Neuropsychopharmacology 2011, 36: 911-911. PMCID: PMC3055722, DOI: 10.1038/npp.2011.2.
- Krystal J, Moghaddam B. Contributions of Glutamate and GABA Systems to the Neurobiology and Treatment of Schizophrenia. 2010, 433-461. DOI: 10.1002/9781444327298.ch21.
- Nakic M, Krystal J, Bhagwagar Z. Neurotransmitter Systems in Bipolar Disorder. 2010, 210-227. DOI: 10.1002/9780470661277.ch16.
- Sen S, Kranzler H, Krystal J, Speller H, Chan G, Gelernter J, Guille C. In Reply. JAMA Psychiatry 2010, 67: 568-569. DOI: 10.1001/archgenpsychiatry.2010.53.
- Cavus I, Guglielmino R, Ford J, Roach B, Krystal J, Gueorguieva R, Mathalon D. IMPAIRED LONG-TERM POTENTIATION OF THE VISUAL EVOKED POTENTIAL IN SCHIZOPHRENIA. Schizophrenia Research 2010, 117: 244-245. DOI: 10.1016/j.schres.2010.02.373.
- Driesen N, McCarthy G, Bhagwagar Z, Calhoun V, D'Souza D, Holub J, Morgan P, Krystal J. NMDA Receptor Antagonist Ketamine Produces Opposing Effects on Resting and Task-Related Brain Activation During Working Memory in Humans. NeuroImage 2009, 47: s145. DOI: 10.1016/s1053-8119(09)71458-2.
- Krystal J. Biological Psychiatry: Real Progress. Biological Psychiatry 2009, 65: 3-4. DOI: 10.1016/j.biopsych.2008.08.026.
- Dickerson D, Pittman B, Ralevski E, Perrino A, Limoncelli D, Edgecombe J, Acampora G, Krystal J, Petrakis I. Ethanol-like effects of thiopental and ketamine in healthy humans. Journal Of Psychopharmacology 2008, 24: 203-211. PMID: 19028835, PMCID: PMC4484757, DOI: 10.1177/0269881108098612.
- Esterlis I, Bois F, Cosgrove K, Stiklus S, Perry E, Tamagnan G, Seibyl J, Krystal J, Staley J. Sex differences in nicotinic acetylcholine receptor availability in heavy alcohol drinkers. NeuroImage 2008, 41: t183. DOI: 10.1016/j.neuroimage.2008.04.150.
- Neumeister A, Czermak C, Henry S, Planeta-Wilson B, Huang H, Ding Y, Krystal J, Nabulsi N, Gallezot J, Carson R. Serotonin-1B receptor imaging in PTSD. NeuroImage 2008, 41: t163. DOI: 10.1016/j.neuroimage.2008.04.130.
- Urban N, Martinez D, Zhou Y, Toda M, Xu X, Kegeles L, Slifstein M, Pearlson G, Krystal J, Abi-Dargham A. New probes for imaging dopamine transmission in at risk subjects for alcoholism. NeuroImage 2008, 41: t143. DOI: 10.1016/j.neuroimage.2008.04.111.
- Heninger G, Krystal J, Duman R, Bunney B, Bowers M, Aghajanian G. The Neuroscience Research Program at the Connecticut Mental Health Center. 2007, 77-95. DOI: 10.1002/9780470994580.ch4.
- Krystal J. Biological Psychiatry: Increasing Impact. Biological Psychiatry 2007, 62: 1203-1204. DOI: 10.1016/j.biopsych.2007.09.021.
- Kaufman J, Massey J, Krystal J, Gelernter J. Reply. Biological Psychiatry 2007, 61: 1113-1115. DOI: 10.1016/j.biopsych.2006.07.004.
- Neumeister A, Charney D, Sanacora G, Krystal J. Neurobiology and Treatment of Depression. 2007 DOI: 10.1002/9780470101001.hcn018.
- D'Souza D, Krystal J. Psychoactive Drugs. 2006 DOI: 10.1002/0470018860.s00599.
- Staley J, Tellioglu T, Bois F, Palazzo C, McGuire-Schwartz N, Cosgrove K, van Dyck C, Tamagnan G, Seibyl J, Krystal J, D'Souza D. [I-123] 5-IA-85380 SPECT imaging of beta2-nicotinic acetylcholine receptors in recently abstinent mentally healthy and schizophrenic smokers. NeuroImage 2006, 31: t154. DOI: 10.1016/j.neuroimage.2006.04.137.
- Perry E, Gil R, Miles D, Brenner L, Macdougall L, Johnson R, Degen K, Gueorguieva R, Petrakis I, Krystal J, D'Souza D. Mazindol Augmentation of Antipsychotic Treatment for Schizophrenic Patients with Comorbid Cocaine Abuse or Dependence. Journal Of Dual Diagnosis 2005, 1: 37-47. DOI: 10.1300/j374v01n01_04.
- Mason G, Bendszus M, Meyerhoff D, Hetherington H, Schweinsburg B, Ross B, Taylor M, Krystal J. Magnetic Resonance Spectroscopic Studies of Alcoholism: From Heavy Drinking to Alcohol Dependence and Back Again. Alcohol Clinical And Experimental Research 2005, 29: 150-158. PMID: 15895489, DOI: 10.1097/01.alc.0000150010.72739.58.
- Daurignac E, Toga A, Jones D, Aronen H, Hommer D, Jernigan T, Krystal J, Mathalon D. Applications of Morphometric and Diffusion Tensor Magnetic Resonance Imaging to the Study of Brain Abnormalities in the Alcoholism Spectrum. Alcohol Clinical And Experimental Research 2005, 29: 159-166. PMID: 15895490, DOI: 10.1097/01.alc.0000150891.72900.62.
- Tsoy M, Krupitsky E, Neznanova O, Burakov A, Didenko T, Masalov D, Romanova T, Bespalov A, Zvartau E, Krystal J. P.3.10 Ethanol-like effects of N-methyl-d-aspartatereceptors antagonist memantine, and its ability to prevent cue induced alcohol craving. European Neuropsychopharmacology 2005, 15: s59-s60. DOI: 10.1016/s0924-977x(05)80177-4.
- Hoffman R, Mathalon D, Ford J, Krystal J. Cortico – (thalamo) – cortical interactions, gamma resonance, and auditory hallucinations in schizophrenia. Behavioral And Brain Sciences 2004, 27: 797-798. DOI: 10.1017/s0140525x04320182.
- Krupitsky E, Rudenko A, Burakov A, Zvartau E, Slavina T, Grinenko A, Krystal J. ANTI-GLUTAMATE TREATMENTS FOR ALCOHOL DETOXIFICATION: A DOUBLE-BLIND PLACEBO-CONTROLLED PILOT STUDY OF LAMOTRIGINE, MEMANTINE, AND TOPIRAMATE. Alcohol Clinical And Experimental Research 2004, 28: 50a. DOI: 10.1097/00000374-200408002-00258.
- Krishnan-Sarin S, Shih J, Krystal J, O’Malley S. HPA AXIS RESPONSIVITY AND ALCOHOL DRINKING: INTERACTIVE EFFECTS OF FAMILY HISTORY OF ALCOHOLISM AND NALTREXONE TREATMENT. Alcohol Clinical And Experimental Research 2004, 28: 73a. DOI: 10.1097/00000374-200408002-00397.
- Malhotra A, Krystal J. Molecular genetics and psychopharmacology. Psychopharmacology 2004, 174: 439-440. DOI: 10.1007/s00213-004-1947-y.
- Petrakis I, O’Malley S, Rounsaville B, Poling J, McHugh-Strong C, Krystal J, VA Naltrexone Study Collaboration Group. Naltrexone augmentation of neuroleptic treatment in alcohol abusing patients with schizophrenia. Psychopharmacology 2004, 174: 300-300. DOI: 10.1007/s00213-004-1881-z.
- D'souza D, Cho H, Perry E, Krystal J. Cannabinoid ‘model’ psychosis, dopamine–cannabinoid interactions and implications for schizophrenia. 2004, 142-165. DOI: 10.1017/cbo9780511543630.012.
- Cho H, Krystal J, D’Souza D. Blood dyscrasias. 2004, 221-238. DOI: 10.1093/med/9780198527480.003.0012.
- Qin J, Mitchell K, Johnson M, Krystal J, Southwick S, Rasmusson A, Allen E. Reactions to and memories for the September 11, 2001 terrorist attacks in adults with posttraumatic stress disorder. Applied Cognitive Psychology 2003, 17: 1081-1097. DOI: 10.1002/acp.987.
- Rasmusson A, Guidotti A, Charney D, Vojvoda D, Lipschitz D, Weisman D, Krystal J. S.20.01 Adrenal & CSF neurosteroids as mediators of HPA axis upregulation and symptom production in premenopausal women with PTSD. European Neuropsychopharmacology 2003, 13: s151-s152. DOI: 10.1016/s0924-977x(03)91680-4.
- Krystal J, D'Souza D, Mathalon D, Belger A, Perry E. S.01.03 Therapeutic implications of the NMDA receptor antagonist model psychosis. European Neuropsychopharmacology 2003, 13: s96. DOI: 10.1016/s0924-977x(03)91600-2.
- Cramer J, Rosenheck R, Kirk G, Krol W, Krystal J, 425 F. Medication Compliance Feedback and Monitoring in a Clinical Trial: Predictors and Outcomes. Value In Health 2003, 6: 566-573. PMID: 14627063, DOI: 10.1046/j.1524-4733.2003.65269.x.
- Hoffman R, Hawkins K, Anderson A, Buchanan R, Wu K, Hampson M, Gueorguieva R, Carroll K, Spencer D, Krystal J. One hertz repetitive transcranial magnetic stimulation delivered to brain areas underlying speech perception reduces persistent auditory hallucinations. Schizophrenia Research 2003, 60: 285-286. DOI: 10.1016/s0920-9964(03)80467-x.
- D'Souza D, Perry E, Riccardi P, Abi-Saab W, Krystal J. Cannabinoids and psychosis: Pharmacological studies with IV delta-9-THC in humans. Schizophrenia Research 2003, 60: 310. DOI: 10.1016/s0920-9964(03)80247-5.
- Jacobsen L, Mencl W, D'Souza D, Pugh K, Skudlarski P, Abi-Saab W, Krystal J. Impact of nicotine on brain function in smokers with schizophrenia. Schizophrenia Research 2003, 60: 223-224. DOI: 10.1016/s0920-9964(03)81196-9.
- Moghaddam B, Krystal J. The Neurochemistry of Schizophrenia. 2003, 349-364. DOI: 10.1002/9780470987353.ch19.
- Krystal J, Petrakis I, D'Souza D, Mason G, Trevisan L. Alcohol and Glutamate Neurotransmission in Humans: Implications for Reward, Dependence, and Treatment. 2002, 0: 389-398. DOI: 10.1385/1-59259-306-2:389.
- Petrakis I, Buonopane A, O???Malley S, Cermik O, Trevisan L, Boutros N, Limoncelli D, Krystal J. The Effect of Tryptophan Depletion on Alcohol Self-Administration in Non-Treatment-Seeking Alcoholic Individuals. Alcohol Clinical And Experimental Research 2002, 26: 969-975. DOI: 10.1097/00000374-200207000-00005.
- Cramer J, Rosenheck R, Krystal J, Kirk G, Krol W. PMH1 USEFULNESS OF ELECTRONIC COMPLIANCE DATA IN AN EFFECTIVENESS TRIAL. Value In Health 2002, 5: 226. DOI: 10.1016/s1098-3015(10)61067-4.
- Krystal J, Cramer J, Krol W, Kirk G, Rosenheck R. Naltrexone in the Treatment of Alcohol Dependence. New England Journal Of Medicine 2001, 345: 1734-1739. PMID: 11742047, DOI: 10.1056/nejmoa011127.
- Sierra M, Phillips M, Lambert M, Senior C, David A, Krystal J. Lamotrigine in the treatment of depersonalization disorder. The Journal Of Clinical Psychiatry 2001, 62: 826-7. PMID: 11816874, DOI: 10.4088/jcp.v62n1012b.
- Krystal J, D’Souza D. Comment on “ketamine has equal affinity for NMDA receptors and the high-affinity state of the dopamine D2 receptor”. Biological Psychiatry 2001, 50: 555. PMID: 11600110, DOI: 10.1016/s0006-3223(01)01258-6.
- Newcomer J, Krystal J. NMDA receptor regulation of memory and behavior in humans. Hippocampus 2001, 11: 529-542. PMID: 11732706, DOI: 10.1002/hipo.1069.
- Krupitsky E, Burakov A, Romanova T, Grinenko N, Grinenko A, Fletcher J, Petrakis I, Krystal J. Attenuation of Ketamine Effects by Nimodipine Pretreatment in Recovering Ethanol Dependent Men: Psychopharmacologic Implications of the Interaction of NMDA and L-Type Calcium Channel Antagonists. Neuropsychopharmacology 2001, 25: 936-947. PMID: 11750186, DOI: 10.1016/s0893-133x(01)00346-3.
- Petrakis I, Trevisan L, Boutros N, Limoncelli D, Cooney N, Krystal J. Effect of Tryptophan Depletion on Alcohol Cue-Induced Craving in Abstinent Alcoholic Patients. Alcohol Clinical And Experimental Research 2001, 25: 1151-1155. DOI: 10.1097/00000374-200108000-00009.
- Petrakis I, Trevisan L, Boutros N, Limoncelli D, Cooney N, Krystal J. Effect of Tryptophan Depletion on Alcohol Cue‐Induced Craving in Abstinent Alcoholic Patients. Alcohol Clinical And Experimental Research 2001, 25: 1151-1155. PMID: 11505046, DOI: 10.1111/j.1530-0277.2001.tb02329.x.
- Chambers R, Krystal J, Self D. A neurobiological basis for substance abuse comorbidity in schizophrenia. Biological Psychiatry 2001, 50: 71-83. PMID: 11526998, PMCID: PMC2913410, DOI: 10.1016/s0006-3223(01)01134-9.
- Krystal J, D'Souza D, Sanacora G, Goddard A, Charney D. CURRENT PERSPECTIVES ON THE PATHOPHYSIOLOGY OF SCHIZOPHRENIA, DEPRESSION, AND ANXIETY DISORDERS. Medical Clinics Of North America 2001, 85: 559-577. PMID: 11349473, DOI: 10.1016/s0025-7125(05)70329-1.
- Mason G, Behar K, Krystal J, Rothman D. Aplicações da ressonância magnética para medidas espectroscópicas da neurotransmissão. Brazilian Journal Of Psychiatry 2001, 23: 6-10. DOI: 10.1590/s1516-44462001000500004.
- Stine S, Grillon C, Morgan III C, Kosten T, Charney D, Krystal J. Methadone patients exhibit increased startle and cortisol response after intravenous yohimbine. Psychopharmacology 2001, 154: 274-281. PMID: 11351934, DOI: 10.1007/s002130000644.
- Boutros N, Lisanby S, Tokuno H, Torello M, Campbell D, Berman R, Malison R, Krystal J, Kosten T. Elevated motor threshold in drug-free, cocaine-dependent patients assessed with transcranial magnetic stimulation. Biological Psychiatry 2001, 49: 369-373. PMID: 11239908, DOI: 10.1016/s0006-3223(00)00948-3.
- D'Souza D, Krystal J. Psychopharmacological challenge studies in psychiatric research. International Review Of Psychiatry 2001, 13: 40-46. DOI: 10.1080/09540260020024187.
- D'Souza D, Krystal J. Psychopharmacological challenge studies in psychiatric research. International Review Of Psychiatry 2001, 13: 40-46. DOI: 10.1080/09540260123077.
- Boutros N, Reid M, Petrakis I, Campbell D, Torello M, Krystal J. Similarities in the Disturbances in Cortical Information Processing in Alcoholism and Aging: A Pilot Evoked Potential Study. International Psychogeriatrics 2000, 12: 513-525. PMID: 11263717, DOI: 10.1017/s1041610200006621.
- Krystal J, Belger A, Abi-Saab W, Moghaddam B, Charney D, Anand A, Madonick S, D’Souza C. Glutamatergic contributions to cognitive dysfunction in schizophrenia. 2000, 126-153. DOI: 10.1093/oso/9780192629937.003.0007.
- Boutros N, Campbell D, Petrakis I, Krystal J, Caporale M, Kosten T. Cocaine use and the mid-latency auditory evoked responses. Psychiatry Research 2000, 96: 117-126. PMID: 11063784, DOI: 10.1016/s0165-1781(00)00207-9.
- Abi-Dargham A, Krystal J. Serotonin Receptors as Targets of Antipsychotic Medications. 2000, 20000744: 79-107. DOI: 10.1201/9781420041774.ch6.
- George T, Krystal J. Comorbidity of psychiatric and substance abuse disorders. Current Opinion In Psychiatry 2000, 13: 327-331. DOI: 10.1097/00001504-200005000-00015.
- Hoffman R, Boutros N, Berman R, Hu S, Rachid F, Schaffer N, Krystal J, Charney D. 401. One Hertz rTMS of left temporoparietal cortex in schizophrenic patients reporting auditory hallucinations. Biological Psychiatry 2000, 47: s122-s123. DOI: 10.1016/s0006-3223(00)00670-3.
- Abi-Saab W, Spencer D, Srihari V, Thompson J, Roth R, Sherwin R, Krystal J. 458. Extracellular levels of GABA and glutamate increase in response to direct electrical stimulation of the hippocampus in humans: an in vivo microdialysis study. Biological Psychiatry 2000, 47: s140. DOI: 10.1016/s0006-3223(00)00728-9.
- Belger A, Krystal J. 203. Working memory: constructs, neural circuits, and pharmacological modulation. Biological Psychiatry 2000, 47: s62. DOI: 10.1016/s0006-3223(00)00295-x.
- Boutros N, Reid C, Campbell D, Torello M, Krystal J. 455. Sensory gating in older healthy adults. Biological Psychiatry 2000, 47: s139. DOI: 10.1016/s0006-3223(00)00725-3.
- Laruelle M, Abi-Dargham A, van Dyck C, Gil R, D’Souza D, Krystal J, Seibyl J, Baldwin R, Innis R. Dopamine and serotonin transporters in patients with schizophrenia: an imaging study with [123I]β-CIT. Biological Psychiatry 2000, 47: 371-379. PMID: 10704949, DOI: 10.1016/s0006-3223(99)00257-7.
- Hoffman R, Boutros N, Hu S, Berman R, Krystal J, Charney D. Transcranial magnetic stimulation and auditory hallucinations in schizophrenia. The Lancet 2000, 355: 1073-1075. PMID: 10744097, DOI: 10.1016/s0140-6736(00)02043-2.
- D’Souza D, Gil R, Cassello K, Morrissey K, Abi-Saab D, White J, Sturwold R, Bennett A, Karper L, Zuzarte E, Charney D, Krystal J. IV glycine and oral d-cycloserine effects on plasma and CSF amino acids in healthy humans. Biological Psychiatry 2000, 47: 450-462. PMID: 10704956, DOI: 10.1016/s0006-3223(99)00133-x.
- Berman R, Cappiello A, Anand A, Oren D, Heninger G, Charney D, Krystal J. Antidepressant effects of ketamine in depressed patients. Biological Psychiatry 2000, 47: 351-354. PMID: 10686270, DOI: 10.1016/s0006-3223(99)00230-9.
- Sanacora G, Mason G, Krystal J. Impairment of GABAergic Transmission in Depression: New Insights from Neuroimaging Studies. Critical Reviews In Neurobiology 2000, 14: 23. PMID: 11253954, DOI: 10.1615/critrevneurobiol.v14.i1.20.
- Krystal J, Bennett A, Abi-Saab D, Belger A, Karper L, D’Souza D, Lipschitz D, Abi-Dargham A, Charney D. Dissociation of ketamine effects on rule acquisition and rule implementation: possible relevance to NMDA receptor contributions to executive cognitive functions. Biological Psychiatry 2000, 47: 137-143. PMID: 10664830, PMCID: PMC10060085, DOI: 10.1016/s0006-3223(99)00097-9.
- Anand A, Berman R, Charney D, Krystal J. Attenuation of ketamine effects in healthy humans by lamotrigine, a drug that reduces glutamate release. Schizophrenia Research 2000, 41: 33. DOI: 10.1016/s0920-9964(00)90372-4.
- Krystal J, D'Souza D, Belger A, Madonick S, Cossello K. Ketamine and amphetamine interactions in healthy humans: Further insights into glutamate-dopamine interactions. Schizophrenia Research 2000, 41: 235-236. DOI: 10.1016/s0920-9964(00)90891-0.
- D'Souza D, Madonick S, Abi-Saab W, Wray Y, MacDougall L, Brush L, Cassello K, Krystal J. Dose-response of acute ethanol administration in schizophrenic patients and controls. Schizophrenia Research 2000, 41: 247. DOI: 10.1016/s0920-9964(00)90923-x.
- D'Souza D, Abi-Saab W, Madonick S, Wray Y, Forselius K, MacDougall L, Brush L, Cassello K, Krystal J. Cannabinoids & psychosis: Evidence from studies with I.V THC in schizophrenic patients and controls. Schizophrenia Research 2000, 41: 33. DOI: 10.1016/s0920-9964(00)90371-2.
- Krystal J, Bremner J, D’Souza D, Anand A, Southwick S, Charney D. The Emerging Neurobiology of Dissociative States. 2000, 307-320. DOI: 10.1007/978-1-4615-4177-6_22.
- Gibbons R, Brown B, Azarnoff D, Bunney W, Cancro R, Gillin J, Hullett S, Killam K, Krystal J, Kupfer D, Stolley P, Pope A, French G. Assessment of the Safety and Efficacy Data for the Hypnotic Halcion(R): Results of an Analysis by an Institute of Medicine Committee. Journal Of The American Statistical Association 1999, 94: 993-1002. DOI: 10.1080/01621459.1999.10473852.
- Gibbons R, Brown B, Azarnoff D, Bunney W, Cancro R, Gillin J, Hullett S, Killam K, Krystal J, Kupfer D, Stolley P, Pope A, French G. Assessment of the Safety and Efficacy Data for the Hypnotic Halcion (R) : Results of an Analysis by an Institute of Medicine Committee. Journal Of The American Statistical Association 1999, 94: 993. DOI: 10.2307/2669913.
- Krystal J, Belger A, D'Souza D, Anand A, Charney D, Aghajanian G, Moghaddam B. Therapeutic Implications of the Hyperglutamatergic Effects of NMDA Antagonists. Neuropsychopharmacology 1999, 21: s143-s157. DOI: 10.1016/s0893-133x(99)00102-5.
- Boutros N, Belger A, Campbell D, D’Souza C, Krystal J. Comparison of four components of sensory gating in schizophrenia and normal subjects: a preliminary report. Psychiatry Research 1999, 88: 119-130. PMID: 10622348, DOI: 10.1016/s0165-1781(99)00074-8.
- Verhoeff N, Soares J, D’Souza C, Gil R, Degen K, Abi-Dargham A, Zoghbi S, Fujita M, Rajeevan N, Seibyl J, Krystal J, van Dyck C, Charney D, Innis R. [123I]Iomazenil SPECT benzodiazepine receptor imaging in schizophrenia. Psychiatry Research 1999, 91: 163-173. PMID: 10641580, DOI: 10.1016/s0925-4927(99)00027-x.
- D’Souza D, Berman R, Krystal J, Charney D. Symptom provocation studies in psychiatric disorders: scientific value, risks, and future. Biological Psychiatry 1999, 46: 1060-1080. PMID: 10536743, DOI: 10.1016/s0006-3223(99)00209-7.
- Krystal J, D'Souza C, Petrakis I, Belger A, Berman R, Charney D, AbiSaab W, Madonick S. NMDA Agonists and Antagonists as Probes of Glutamatergic Dysfunction and Pharmacotherapies in Neuropsychiatric Disorders. Harvard Review Of Psychiatry 1999, 7: 125-143. PMID: 10483932, DOI: 10.3109/hrp.7.3.125.
- Krystal J. NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disorders. Harvard Review Of Psychiatry 1999, 7: 125-143. DOI: 10.1093/hrp/7.3.125.
- Krupitsky E, Burakov A, Romanova T, Vegso S, Krystal J. Nimodipine attenuates psychotigenic effects of ketamine in humans. European Neuropsychopharmacology 1999, 9: 347. DOI: 10.1016/s0924-977x(99)80514-8.
- Petrakis I, Trevisan L, D'Souza C, Gil R, Krasnicki S, Webb E, Heninger G, Cooney N, Krystal J. CSF Monoamine Metabolite and Beta Endorphin Levels in Recently Detoxified Alcoholics and Healthy Controls. Alcohol Clinical And Experimental Research 1999, 23: 1336. DOI: 10.1097/00000374-199908000-00007.
- Petrakis I, Trevisan L, D'Souza C, Gil R, Krasnicki S, Webb E, Heninger G, Cooney N, Krystal J. CSF Monoamine Metabolite and Beta Endorphin Levels in Recently Detoxified Alcoholics and Healthy Controls: Prediction of Alcohol Cue‐Induced Craving? Alcohol Clinical And Experimental Research 1999, 23: 1336-1341. PMID: 10470976, DOI: 10.1111/j.1530-0277.1999.tb04355.x.
- Hoffman R, Boutros N, Berman R, Roessler E, Belger A, Krystal J, Charney D. Transcranial magnetic stimulation of left temporoparietal cortex in three patients reporting hallucinated “voices”. Biological Psychiatry 1999, 46: 130-132. PMID: 10394483, DOI: 10.1016/s0006-3223(98)00358-8.
- Krystal J, D’Souza D, Karper L, Bennett A, Abi-Dargham A, Abi-Saab D, Cassello K, Bowers Jr. M, Vegso S, Heninger G, Charney D, Bowers M. Interactive effects of subanesthetic ketamine and haloperidol in healthy humans. Psychopharmacology 1999, 145: 193-204. PMID: 10463321, DOI: 10.1007/s002130051049.
- Delgado P, Miller H, Salomon R, Licinio J, Krystal J, Moreno F, Heninger G, Charney D. Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action. Biological Psychiatry 1999, 46: 212-220. PMID: 10418696, DOI: 10.1016/s0006-3223(99)00014-1.
- Abi-Dargham A, Laruelle M, Krystal J, D'Souza C, Zoghbi S, Baldwin R, Seibyl J, Mawlawi O, de Erasquin G, Charney D, Innis R. No Evidence of Altered In Vivo Benzodiazepine Receptor Binding in Schizophrenia. Neuropsychopharmacology 1999, 20: 650-661. PMID: 10327433, DOI: 10.1016/s0893-133x(98)00107-9.
- Sanacora G, Rothman D, Krystal J. Applications of Magnetic Resonance Spectroscopy to Psychiatry. The Neuroscientist 1999, 5: 192-196. DOI: 10.1177/107385849900500316.
- Fujita M, Woods S, Verhoeff N, Abi-Dargham A, Baldwin R, Zoghbi S, Soares J, Jatlow P, Krystal J, Rajeevan N, Charney D, Seibyl J, Innis R. Changes of benzodiazepine receptors during chronic benzodiazepine administration in humans. European Journal Of Pharmacology 1999, 368: 161-172. PMID: 10193652, DOI: 10.1016/s0014-2999(99)00013-8.
- Sanacora G, Mason G, Rothman D, Berman R, Charney D, Ciarcia J, Krystal J. 1. ECT Effects on Cortical GABA Levels as Determined by 1H-MRS. Journal Of Ect 1999, 15: 102. DOI: 10.1097/00124509-199903000-00009.
- Krystal J, D'Souza D, Madonick S, Petrakis I. Toward a rational pharmacotherapy of comorbid substance abuse in schizophrenic patients. Schizophrenia Research 1999, 35: s35-s49. PMID: 10190224, DOI: 10.1016/s0920-9964(98)00162-5.
- Belger A, Puce A, Krystal J, Gore J, Goldman‐Rakic P, McCarthy G. Dissociation of mnemonic and perceptual processes during spatial and nonspatial working memory using fMRI. Human Brain Mapping 1998, 6: 14-32. PMID: 9673660, PMCID: PMC6873355, DOI: 10.1002/(sici)1097-0193(1998)6:1<14::aid-hbm2>3.0.co;2-o.
- Sernyak M, Glazer W, Heninger G, Charney D, Woods S, Petrakis I, Krystal J, Price L. Naltrexone Augmentation of Neuroleptics in Schizophrenia. Journal Of Clinical Psychopharmacology 1998, 18: 248-251.. PMID: 9617985, DOI: 10.1097/00004714-199806000-00011.
- Hoffman R, Boutros N, Berman R, Krystal J, Charney D. 310. Transcranial magnetic stimulation and hallucinated ‘voices’. Biological Psychiatry 1998, 43: s93. DOI: 10.1016/s0006-3223(98)90758-2.
- Boutros N, Krystal J, Gelernter J. 295. Sensory gating and cocaine induced paranoia. Biological Psychiatry 1998, 43: s89. DOI: 10.1016/s0006-3223(98)90743-0.
- D'Souza D, Belger A, Abi-Saab W, Adams S, Gil R, Larvey K, Cassello K, Sernyak M, Krystal J. 435. Dose-response of THC effects in schizophrenics and healthy controls. Biological Psychiatry 1998, 43: s130-s131. DOI: 10.1016/s0006-3223(98)90883-6.
- Krystal J, Moghaddam B, Breier A, Goldman-Rakic P, McElvey J. 204. Glutamate, dopamine, the frontal cortex, and schizophrenia. Biological Psychiatry 1998, 43: s60. DOI: 10.1016/s0006-3223(98)90652-7.
- Hillbrand M, Spitz R, Foster H, Krystal J, Young J. Creatine Kinase Elevations and Aggressive Behavior in Hospitalized Forensic Patients. Psychiatric Quarterly 1998, 69: 69-82. PMID: 9536476, DOI: 10.1023/a:1022137524475.
- Krystal J. Excitatory Amino Acids: Clinical Results with Antagonists. The Yale Journal Of Biology And Medicine 1998, 71: 409-410. PMCID: PMC2578927.
- Belger A, Kirino E, McCarthy G, Gore J, Krystal J. Assessment of prefrontal activation by infrequent visual targets and non-target novel stimuli in schizophrenia: A functional MRI study. Schizophrenia Research 1998, 29: 106. DOI: 10.1016/s0920-9964(97)88567-2.
- Krystal J, Karper L, Bennett A, D’Souza D, Abi-Dargham A, Morrissey K, Abi-Saab D, Bremner J, Bowers Jr. M, Suckow R, Stetson P, Heninger G, Charney D. Interactive effects of subanesthetic ketamine and subhypnotic lorazepam in humans. Psychopharmacology 1998, 135: 213-229. PMID: 9498724, DOI: 10.1007/s002130050503.
- Measurement of dissociative states with the Clinician‐Administered Dissociative States Scale (CADSS)Bremner J, Krystal J, Putnam F, Southwick S, Marmar C, Charney D, Mazure C. Measurement of dissociative states with the Clinician‐Administered Dissociative States Scale (CADSS). Journal Of Traumatic Stress 1998, 11: 125-136. PMID: 9479681, DOI: 10.1023/a:1024465317902.
- Krystal J, Nagy L, Rasmusson A, Morgan A, Cottrol C, Southwick S, Charney D. Initial Clinical Evidence of Genetic Contributions to Posttraumatic Stress Disorder. 1998, 657-667. DOI: 10.1007/978-1-4757-5567-1_39.
- Abi-Dargham A, Charney D, Krystal J. Benzodiazepine Receptor Antagonists. CNS Drugs 1997, 8: 244-256. DOI: 10.2165/00023210-199708030-00007.
- Stine S, Krystal J, Petrakis I, Jatlow P, Heninger G, Kosten T, Chamey D. Effect of alpha-methyl-para-tyrosine on response to cocaine challenge. Biological Psychiatry 1997, 42: 181-190. PMID: 9232210, DOI: 10.1016/s0006-3223(96)00331-9.
- SOUTHWICK S, MORGAN CA, BREMNER A, GRILLON C, KRYSTAL J, NAGY L, CHARNEY D. Noradrenergic Alterations in Posttraumatic Stress Disorder. Annals Of The New York Academy Of Sciences 1997, 821: 125-141. PMID: 9238199, DOI: 10.1111/j.1749-6632.1997.tb48274.x.
- Krystal J, Webb E, Grillon C, Cooney N, Casal L, Morgan III. C, Southwick S, Davis M, Charney D. Evidence of acoustic startle hyperreflexia in recently detoxified early onset male alcoholics: modulation by yohimbine and m-Chlorophenylpiperazine (mCPP). Psychopharmacology 1997, 131: 207-215. PMID: 9203230, DOI: 10.1007/s002130050285.
- Cramer J, Krystal J, Rosenheck R, Rounsaville B, Krol W, Collins J. P111 Protocol enhancements for a study of alcohol-dependent patients. Contemporary Clinical Trials 1997, 18: s179. DOI: 10.1016/s0197-2456(97)91206-x.
- Zuzarte E, D’Souza D, Gil R, Genovese A, White J, Charney D, Krystal J. 617 Dose-related ethanol effects in schizophrenic patients. Schizophrenia Research 1997, 24: 218. DOI: 10.1016/s0920-9964(97)82625-4.
- Behar K, Rothman D, D’Souza D, Gil R, Petroff O, Abi-Saab D, Zuzarte E, Hooten M, Petrakis I, Sernyak M, White J, Webb E, Charnay D, Krystal J. 496 Preliminary assessment of cortical gaba levels in schizophrenics using magnetic resonance spectroscopy. Schizophrenia Research 1997, 24: 175-176. DOI: 10.1016/s0920-9964(97)82504-2.
- Salomon R, Miller H, Krystal J, Heninger G, Charney D. Lack of behavioral effects of monoamine depletion in healthy subjects. Biological Psychiatry 1997, 41: 58-64. PMID: 8988796, DOI: 10.1016/0006-3223(95)00670-2.
- D’Souza D, Gil R, Zuzarte E, Zimmerman L, Abi-Saab D, Damon D, White J, Semyak M, Krystal J. 602 Tetrahydrocannabinol effects in schizophrenic subjects & healthy controls. Schizophrenia Research 1997, 24: 213. DOI: 10.1016/s0920-9964(97)82610-2.
- Belger A, McNulty A, Krystal J. 356 Behavioral assessment of frontal/ cingulate attention deficits in schizophrenia. Schizophrenia Research 1997, 24: 129. DOI: 10.1016/s0920-9964(97)82364-x.
- Belger A, Taqqu Y, Krystal J. 357 Behavioral dissociation of working memory and selective attention functions in schizophrenia. Schizophrenia Research 1997, 24: 129-130. DOI: 10.1016/s0920-9964(97)82365-1.
- D’Souza D, Gil R, Zuzarte E, Abi-Saab D, Damon D, White J, Zimmerman L, Krystal J. 601 Glycine ketamine interactions in healthy humans. Schizophrenia Research 1997, 24: 213. DOI: 10.1016/s0920-9964(97)82609-6.
- Zuzarte E, D’Souza D, Gil R, White J, AbiSaab D, Charney D, Krystal J. 618 Evaluation of lorazepam blockade of M-chlorophenylpiperazine (MCPP) effects in schizophrenia. Schizophrenia Research 1997, 24: 218. DOI: 10.1016/s0920-9964(97)82626-6.
- Laruelle M, Abi-Dargham A, Krystal J, Charney D, Innis R. 507 In vivo evaluation of dopamine synaptic funcflon in untreated schizophrenic patients. Schizophrenia Research 1997, 24: 179. DOI: 10.1016/s0920-9964(97)82515-7.
- Petrakis I, Satel S, Stine S, Kosten T, Namanworth S, Charney D, Krystal J. AMPT Effects on Cue‐Induced Craving for Cocaine. American Journal On Addictions 1996, 5: 313-320. DOI: 10.1111/j.1521-0391.1996.tb00317.x.
- McCarthy G, Puce A, Constable T, Krystal J, Gore J, Goldman-Rakic P. Activation of Human Prefrontal Cortex during Spatial and Nonspatial Working Memory Tasks Measured by Functional MRI. Cerebral Cortex 1996, 6: 600-611. PMID: 8670685, DOI: 10.1093/cercor/6.4.600.
- D’Souza D, Abi-Saab D, Damon D, White J, Gil R, Krystal J. O-22-11 Dose response of D-Cycloserine, a partial NMDA-Glycine site agonist, in schizophrenia. European Neuropsychopharmacology 1996, 6: 149. DOI: 10.1016/0924-977x(96)87994-6.
- Bremner J, Krystal J, Southwick S, Charney D. Noradrenergic mechanisms in stress and anxiety: II. Clinical studies. Synapse 1996, 23: 39-51. PMID: 8723134, DOI: 10.1002/(sici)1098-2396(199605)23:1<39::aid-syn5>3.0.co;2-i.
- Bremner J, Krystal J, Southwick S, Charney D. Noradrenergic mechanisms in stress and anxiety: I. preclinical studies. Synapse 1996, 23: 28-38. PMID: 8723133, DOI: 10.1002/(sici)1098-2396(199605)23:1<28::aid-syn4>3.0.co;2-j.
- Krystal J, Compere S, Nestler E, Rasmussen K. Nimodipine reduction of naltrexone-precipitated locus coeruleus activation and abstinence behavior in morphine-dependent rats. Physiology & Behavior 1996, 59: 863-866. PMID: 8778878, DOI: 10.1016/0031-9384(95)02206-6.
- Laruelle M, Abi-Dargham A, van Dyck C, Krystal J, Charney D, Innis R. 208. Increased striatal dopamine release in drug free schizophrenic subjects. Biological Psychiatry 1996, 39: 560. DOI: 10.1016/0006-3223(96)84153-9.
- Gil R, D’Souza D, Zuzarte E, Damon D, Genovese A, Boutros N, Abi-Dargham A, Innis R, Charney D, Krystal J. 326. GABA-serotonin interactions in healthy subjects: Implications for psychosis. Biological Psychiatry 1996, 39: 595-596. DOI: 10.1016/0006-3223(96)84271-5.
- Hillbrand M, Young J, Krystal J. Recurrent self-injurious behavior in forensic patients. Psychiatric Quarterly 1996, 67: 33-45. PMID: 8623037, DOI: 10.1007/bf02244273.
- Laruelle M, Abi-Dargham A, Gil R, van Dyck C, Erdos J, D'Souza D, Rosenblatt W, McCance-Katz E, Zea-Ponce Y, Zoghbi S, Baldwin R, Hoffer P, Krystal J, Charney D, Innis R. SPECT imaging of synaptic dopamine release in drug free schizophrenic patients: An experimental validation of the dopamine hypothesis of schizophrenia. Schizophrenia Research 1996, 18: 198-199. DOI: 10.1016/0920-9964(96)85619-2.
- D'Souza D, White J, Abi-Saab D, Damon D, Gil R, Zuzarte E, Krystal J. Dose response of oral D-cycloserine in unmedicated and medicated schizophrenics. Schizophrenia Research 1996, 18: 134. DOI: 10.1016/0920-9964(96)85447-8.
- Petrakis I, Satel S, Stine S, Kosten T, Namanworth S, Charney D, Krystal J. AMPT Effects on Cue-Induced Craving for Cocaine. American Journal On Addictions 1996, 5: 313-320. DOI: 10.3109/10550499608995682.
- Krystal J, Bennett A, Bremner J, Southwick S, Charney D. Recent Developments in the Neurobiology of Dissociation. 1996, 163-190. DOI: 10.1007/978-1-4899-0310-5_8.
- Stine S, Krystal J, Kosten T, Charney D. Mazindol treatment for cocaine dependence. Drug And Alcohol Dependence 1995, 39: 245-252. PMID: 8556974, DOI: 10.1016/0376-8716(95)01174-4.
- Bremner J, Krystal J, Southwick S, Charney D. Functional neuroanatomical correlates of the effects of stress on memory. Journal Of Traumatic Stress 1995, 8: 527-553. PMID: 8564272, DOI: 10.1002/jts.2490080403.
- Bremner J, Krystal J, Southwick S, Charney D. Functional neuroanatomical correlates of the effects of stress on memory. Journal Of Traumatic Stress 1995, 8: 527-553. DOI: 10.1007/bf02102888.
- D'Souza D, Charney D, Krystal J. Glycine Site Agonists of the NMDA Receptor: A Review. CNS Neuroscience & Therapeutics 1995, 1: 227-260. DOI: 10.1111/j.1527-3458.1995.tb00285.x.
- Randall P, Bremner J, Krystal J, Nagy L, Heninger G, Nicolaou A, Charney D. Effects of the benzodiazepine antagonist flumazenil in PTSD. Biological Psychiatry 1995, 38: 319-324. PMID: 7495926, DOI: 10.1016/0006-3223(94)00306-n.
- Goddard A, Charney D, Germine M, Woods S, Heninger G, Krystal J, Goodman W, Price L. Effects of tryptophan depletion on responses to yohimbine in healthy human subjects. Biological Psychiatry 1995, 38: 74-85. PMID: 7578653, DOI: 10.1016/0006-3223(94)00223-p.
- Abi-Dargham A, Krystal J, Laruelle M, D'Souza D, Zoghbi S, Brenner L, Gil R, Sernyak M, Baldwin R, Zubal G, Hoffer P, Charney D, Innis R. Spect imaging of the benzodiazepine receptor in schizophrenics and healthy subjects. Schizophrenia Research 1995, 15: 75. DOI: 10.1016/0920-9964(95)95236-3.
- Krystal J, Karper L, Bennett A, Abi-Saab D, D'Souza C, Abi-Dargham A, Charney D. Modulating ketamine-induced thought disorder with lorazepam and haloperidol in humans. Schizophrenia Research 1995, 15: 156-157. DOI: 10.1016/0920-9964(95)95485-r.
- Bennett A, Abi-Saab D, Karper L, D'Souza D, Abi-Dargham A, Charney D, Krystal J. Ketamine impairs learning, but not procedural expression, on the wisconsin card sorting test. Schizophrenia Research 1995, 15: 108-109. DOI: 10.1016/0920-9964(95)95333-5.
- Belger A, McCarthy G, Gore J, Puce A, Constable T, Krystal J. Evaluation of frontal and parietal association cortex contributions to attention using fMRI. Schizophrenia Research 1995, 15: 76. DOI: 10.1016/0920-9964(95)95239-6.
- Karper L, Grillon C, Abi-Saab D, Morgan C, Charney D, Krystal J. The effect of ketamine on pre-pulse inhibition and attention. Schizophrenia Research 1995, 15: 180. DOI: 10.1016/0920-9964(95)95554-m.
- Krystal J, Karper L, D'Souza C, Webb E, Bennett A, Abi-Dargham A, Petrakis I, Brenner L, Morrissey K, Abi-Saab D, Charney D. Differentiating nmda dysregulation in schizophrenia and alcoholism using ketamine. Schizophrenia Research 1995, 15: 156. DOI: 10.1016/0920-9964(95)95484-q.
- D'Souza D, Morrissey K, Abi-Saab D, Damon D, Gil R, Bennett A, Krystal J. Intravenous glycine and oral d-Cycloserine effects on CSF Amino acids, plasma hormones and behavior in healthy humans: Implications for schizophrenia. Schizophrenia Research 1995, 15: 147. DOI: 10.1016/0920-9964(95)95456-j.
- McDougle C, Price L, Heninger G, Krystal J, Charney D. Noradrenergic response to acute ethanol administration in heathly subjects: comparison with intravenous yohimbine. Psychopharmacology 1995, 118: 127-135. PMID: 7617798, DOI: 10.1007/bf02245830.
- HILLBRAND M, YOUNG J, KRYSTAL J. Discontinuing Anticonvulsant Treatment of Aggression. Journal Of Neuropsychiatry 1995, 7: 116-a-117. PMID: 7711482, DOI: 10.1176/jnp.7.1.116-a.
- Krystal J, Woods S, Kosten T, Rosen M, Seibyl J, Van Dyck C, Price L, Zubal I, Hoffer P, Charney D. Opiate Dependence and Withdrawal: Preliminary Assessment Using Single Photon Emission Computerized Tomography (SPECT). The American Journal Of Drug And Alcohol Abuse 1995, 21: 47-63. PMID: 7762544, DOI: 10.3109/00952999509095229.
- Southwick S, Krystal J, Johnson D, Charney D. Neurobiology of Post-Traumatic Stress Disorder. 1995, 49-72. DOI: 10.1007/978-1-4899-1034-9_4.
- Southwick S, Krystal J, Charney D. Relationship of Panic Disorder to Posttraumatic Stress Disorder-Reply. JAMA Psychiatry 1995, 52: 77-78. DOI: 10.1001/archpsyc.1995.03950130077012.
- van Dyck C, Rosen M, Thomas H, McMahon T, Wallace E, O'Connor P, Sullivan M, Krystal J, Hoffer P, Woods S, Kosten T. SPECT regional cerebral blood flow alterations in naltrexone-precipitated withdrawal from buprenorphine. Psychiatry Research 1994, 55: 181-191. PMID: 7701033, DOI: 10.1016/0925-4927(94)90013-2.
- Salomon R, Delgado P, Licinio J, Krystal J, Heninger G, Charney D. Effects of sleep deprivation on serotonin function in depression. Biological Psychiatry 1994, 36: 840-846. PMID: 7893848, DOI: 10.1016/0006-3223(94)90595-9.
- Karper L, Bennett A, Erdos J, Krystal J. ANTIPSYCHOTICS, LITHIUM, BENZODIAZEPINES, BETA-BLOCKERS. Journal Of Offender Rehabilitation 1994, 21: 203-222. DOI: 10.1300/j076v21n03_13.
- D'SOUZA D, BENNETT A, ABI-DARGHAM A, KRYSTAL J. Precipitation of a Psychoneuromotor Syndrome by Fluoxetine in a Haloperidol-. Journal Of Clinical Psychopharmacology 1994, 14: 361-362. PMID: 7806697, DOI: 10.1097/00004714-199410000-00018.
- Southwick S, Bremner D, Krystal J, Charney D. Psychobiologic Research in Post-Traumatic Stress Disorder. Psychiatric Clinics Of North America 1994, 17: 251-264. PMID: 7937357, DOI: 10.1016/s0193-953x(18)30112-6.
- Brenner L, Karper L, Krystal J. Short-Term Use of Disulfiram With Clozapine. Journal Of Clinical Psychopharmacology 1994, 14: 213-214. PMID: 8027424, DOI: 10.1097/00004714-199406000-00016.
- D'Souza D, Gil R, Abi-Dargham A, Karper L, Abi-Saab D, Morrissey K, Brenner L, Charney D, Krystal J. Tryptophan depletion paradigm: Implications for schizophrenia. Biological Psychiatry 1994, 35: 703. DOI: 10.1016/0006-3223(94)90974-1.
- D'Souza D, Bennett A, Karper L, Gil R, Morrissey K, Abi-Saab D, Charney D, Krystal J. I.V. glycine/d-cycloserine to facilitate NMDA function in humans. Biological Psychiatry 1994, 35: 734. DOI: 10.1016/0006-3223(94)91085-5.
- Karper L, Grillon C, Lysaker P, Bell M, Charney D, Krystal J. Soft signs, attention, and startle in schizophrenia. Biological Psychiatry 1994, 35: 714. DOI: 10.1016/0006-3223(94)91014-6.
- Krystal J, Southwick S, Charney D. Alcohol Dependence May Be the Missing Link Between Posttraumatic Stress Disorder and Panic-Reply. JAMA Psychiatry 1994, 51: 430-430. DOI: 10.1001/archpsyc.1994.03950050090014.
- DOCHERTY N, EVANS I, SLEDGE W, SEIBYL J, KRYSTAL J. Affective Reactivity of Language in Schizophrenia. The Journal Of Nervous And Mental Disease 1994, 182: 98-103. PMID: 8308539, DOI: 10.1097/00005053-199402000-00006.
- D'Souza D, Krystal J. Perturbing the Organism: The Biology of Stressful Experience. The Journal Of Nervous And Mental Disease 1994, 182: 126. DOI: 10.1097/00005053-199402000-00023.
- HILLBRAND M, KRYSTAL J, SHARPE K, FOSTER H. Clinical Predictors of Self-Mutilation in Hospitalized Forensic Patients. The Journal Of Nervous And Mental Disease 1994, 182: 9-16. PMID: 8277305, DOI: 10.1097/00005053-199401000-00003.
- Krystal J, Karper L, Abi-Dargham A, Delaney R, Bremmer J, Bowers M, Charney D. Ketamine effects reduced by lorazepam in healthy humans. Schizophrenia Research 1993, 9: 241. DOI: 10.1016/0920-9964(93)90539-u.
- Krystal J, Karper L, Seibyl J, Delaney R, Bremner J, Bowers M, Charney D. Dose-related effects of the NMDA antagonist, ketamine, in healthy humans. Schizophrenia Research 1993, 9: 240-241. DOI: 10.1016/0920-9964(93)90538-t.
- Abi-Dargham A, Seibyl J, Laruelle M, Rattner Z, Zoghbi S, Baldwin R, Ponce Y, Charney D, Hoffer P, Krystal J, Innis R. Spect imaging of the benzodiazepine receptor in humans using [123I]iomazenil. Schizophrenia Research 1993, 9: 191. DOI: 10.1016/0920-9964(93)90389-z.
- Karper L, Bell M, Lysaker P, Seibyl J, Beam-Goulet J, Brenner L, Krystal J. The neurological evaluation scale (NES): Factor analysis and clinical correlates. Schizophrenia Research 1993, 9: 179. DOI: 10.1016/0920-9964(93)90354-l.
- Karper L, Freeman G, Morgan C, Grillon C, Charney D, Krystal J. Pre-pulse inhibition of the acoustic startle response and measures of attention in schizophrenic subjects. Schizophrenia Research 1993, 9: 160. DOI: 10.1016/0920-9964(93)90296-u.
- NAGY L, KRYSTAL J, CHARNEY D, MERIKANGAS K, WOODS S. Long-Term Outcome of Panic Disorder After Short-Term Imipramine and Behavioral Group Treatment. Journal Of Clinical Psychopharmacology 1993, 13: 16-24. PMID: 8098050, DOI: 10.1097/00004714-199302000-00003.
- SEIBYL J, SATEL S, ANTHONY D, SOUTHWICK S, KRYSTAL J, CHARNEY D. Effects of Cocaine on Hospital Course in Schizophrenia. The Journal Of Nervous And Mental Disease 1993, 181: 31-37. PMID: 8093475, DOI: 10.1097/00005053-199301000-00006.
- Krystal J. Stress, the Aging Brain, and the Mechanisms of Neuron Death. The Yale Journal Of Biology And Medicine 1993, 66: 109-110. PMCID: PMC2588844.
- Kosten T, Krystal J, Giller E, Frank J, Dan E. Alexithymia as a predictor of treatment response in post-traumatic stress disorder. Journal Of Traumatic Stress 1992, 5: 563-573. DOI: 10.1007/bf00979225.
- Kosten T, Krystal J, Giller E, Frank J, Dan E. Alexithymia as a predictor of treatment response in post‐traumatic stress disorder. Journal Of Traumatic Stress 1992, 5: 563-573. DOI: 10.1002/jts.2490050406.
- Krystal J, McDougle C, Woods S, Price L, Heninger G, Charney D. Dose-response relationship for oral idazoxan effects in healthy human subjects: comparison with oral yohimbine. Psychopharmacology 1992, 108: 313-319. PMID: 1355923, DOI: 10.1007/bf02245117.
- Seibyl J, Brenner L, Krystal J, Johnson R, Charney D. Mazindol and cocaine addiction in schizophrenia. Biological Psychiatry 1992, 31: 1179-1181. PMID: 1525287, DOI: 10.1016/0006-3223(92)90171-u.
- KARPER L, SEIBYL J, KRYSTAL J. Valproate Management of Psychosis in a Patient with Carbamazepine-Induced Hyponatremia. Journal Of Clinical Psychopharmacology 1992, 12: 137-138. PMID: 1573038, DOI: 10.1097/00004714-199204000-00015.
- WOODS S, NAGY L, KOLESZAR A, KRYSTAL J, HENINGER G, CHARNEY D. Controlled Trial of Alprazolam Supplementation During Imipramine Treatment of Panic Disorder. Journal Of Clinical Psychopharmacology 1992, 12: 32-38. PMID: 1552038, DOI: 10.1097/00004714-199202000-00006.
- WOODS S, NAGY L, KOLESZAR A, KRYSTAL J, HENINGER G, CHAEY D. Controlled Trial of Alprazolam Supplementation During Imipramine Treatment of Panic Disorder. Current Opinion In Cardiology 1992, 7: 32. DOI: 10.1097/00001573-199202000-00006.
- Krystal J. Invited commentary: complexities in evaluating neurobiological models for stress resistance. Journal Of Psychopharmacology 1992, 6: 12-14. PMID: 22291236, DOI: 10.1177/026988119200600105.
- Krystal J, Price L, Opsahl C, Ricaurte G, Heninger G. Chronic 3,4-Methylenedioxymethamphetamine (MDMA) Use: Effects on Mood and Neuropsychological Function? The American Journal Of Drug And Alcohol Abuse 1992, 18: 331-341. PMID: 1357957, DOI: 10.3109/00952999209026070.
- Krystal J, McDougle C, Kosten T, Price L, Aghajanian G, Charney D. Baclofen-assisted detoxification from opiates A pilot study. Journal Of Substance Use And Addiction Treatment 1992, 9: 139-142. PMID: 1324986, DOI: 10.1016/0740-5472(92)90081-x.
- Krystal J. Trauma and the Vietnam War Generation. The Yale Journal Of Biology And Medicine 1992, 65: 543-544. PMCID: PMC2589725.
- Krystal J. Novel Antipsychotic Drugs. The Yale Journal Of Biology And Medicine 1992, 65: 539-540. PMCID: PMC2589751.
- Rasmussen K, Krystal J, Aghajanian G. Excitatory amino acids and morphine withdrawal: differential effects of central and peripheral kynurenic acid administration. Psychopharmacology 1991, 105: 508-512. PMID: 1771218, DOI: 10.1007/bf02244371.
- Krystal J, Woods S, Hill C, Charney D. Characteristics of panic attack subtypes: Assessment of spontaneous panic, situational panic, sleep panic, and limited symptom attacks. Comprehensive Psychiatry 1991, 32: 474-480. PMID: 1778074, DOI: 10.1016/0010-440x(91)90026-9.
- Seibyl J, Krystal J, Price L, Woods S, D'Amico C, Heninger G, Charney D. Effects of ritanserin on the behavioral, neuroendocrine, and cardiovascular responses to meta-chlorophenylpiperazine in healthy human subjects. Psychiatry Research 1991, 38: 227-236. PMID: 1754635, DOI: 10.1016/0165-1781(91)90013-f.
- Nagy L, Krystal J, Charney D, Woods S. Follow-up Study of Patients With Panic Disorder-Reply. JAMA Psychiatry 1991, 48: 861-862. DOI: 10.1001/archpsyc.1991.01810330085018.
- Licinio J, Krystal J, Seibyl J, Altemus M, Charney D. Elevated central levels of interleukin-2 in drug-free schizophrenic patients. Schizophrenia Research 1991, 4: 372. DOI: 10.1016/0920-9964(91)90301-7.
- Krystal J, Seibyl J, Price L, Woods S, Heninger G, Charney D. MCPP effects in schizophrenic patients before and after typical and atypical neuroleptic treatment. Schizophrenia Research 1991, 4: 350. DOI: 10.1016/0920-9964(91)90266-t.
- Deutch A, Moghaddam B, Innis R, Krystal J, Aghajanian G, Bunney B, Charney D. Mechanisms of action of atypical antipsychotic drugs Implications for novel therapeutic strategies for schizophrenia. Schizophrenia Research 1991, 4: 121-156. PMID: 1674882, DOI: 10.1016/0920-9964(91)90030-u.
- Woods S, Charney D, Silver J, Krystal J, Heninger G. Behavioral, biochemical, and cardiovascular responses to the benzodiazepine receptor antagonist flumazenil in panic disorder. Psychiatry Research 1991, 36: 115-127. PMID: 1850142, DOI: 10.1016/0165-1781(91)90124-8.
- Woods S, O'malley S, Martini B, Mcdougle C, Price L, Krystal J, Hoffer P, Kosten T. Spect regional cerebral blood flow and neuropsychological testing in non-demented HIV-positive drug abusers: Preliminary results. Progress In Neuro-Psychopharmacology And Biological Psychiatry 1991, 15: 649-662. PMID: 1956993, DOI: 10.1016/0278-5846(91)90055-6.
- Charney D, Krystal J, Southwick S, Nagy L, Woods S, Heninger G. Serotonin Function in Panic and Generalized Anxiety Disorders. Psychiatric Annals 1990, 20: 593-602. DOI: 10.3928/0048-5713-19901001-11.
- CHARNEY D, WOODS S, KRYSTAL J, HENINGER G. Serotonin Function and Human Anxiety Disordersa. Annals Of The New York Academy Of Sciences 1990, 600: 558-572. PMID: 2252335, DOI: 10.1111/j.1749-6632.1990.tb16910.x.
- Rasmussen K, Beitner-Johnson D, Krystal J, Aghajanian G, Nestler E. Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates. Journal Of Neuroscience 1990, 10: 2308-2317. PMID: 2115910, PMCID: PMC6570391, DOI: 10.1523/jneurosci.10-07-02308.1990.
- Charney D, Woods S, Krystal J, Heninger G. Neurobiological Mechanisms of Human Anxiety. 1990, 3: 242-283. DOI: 10.1159/000417680.
- Price L, Krystal J, Heninger G, Ricaurte G. Second Thoughts on 3,4-Methylenedioxymethamphetamine (MDMA) Neurotoxicity-Reply. JAMA Psychiatry 1990, 47: 289-289. DOI: 10.1001/archpsyc.1990.01810150089015.
- Kosten T, Krystal J, Charney D, Price L, Morgan C, Kleber H. Opioid antagonist challenges in buprenorphine maintained patients. Drug And Alcohol Dependence 1990, 25: 73-78. PMID: 2323312, DOI: 10.1016/0376-8716(90)90144-4.
- SEIBYL J, KRYSTAL J, CHARNEY D. Marijuana (cannabis) use is anecdotally said to precipitate anxiety symptoms in patients with panic disorder. Is there any research evidence to support this? Also, can marijuana use precipitate or expose paranoia in patients with an underlying bipolar disorder? Journal Of Clinical Psychopharmacology 1990, 10: 78. PMID: 2307743, DOI: 10.1097/00004714-199002000-00033.
- Price L, Charney D, Delgado P, Goodman W, Krystal J, Woods S, Heninger G. Clinical studies of 5-HT function using I.V. l-Tryptophan. Progress In Neuro-Psychopharmacology And Biological Psychiatry 1990, 14: 459-472. PMID: 2236580, DOI: 10.1016/0278-5846(90)90002-x.
- Koster K, Woods S, Smith E, Zubal I, Krystal J, Charney D, Hoffer P. REGIONAL CEREBRAL BLOOD FLOW CHANGES IN PATIENTS WITH PANIC DISORDER. Clinical Nuclear Medicine 1989, 14: 234. DOI: 10.1097/00003072-198903000-00039.
- Woods S, Hegeman I, Krystal J, Smith E, Zubal I, Koster K, Hotfer P. EFFECTS OF VISUAL STIMULATION ON DISTRIBUTION OF TC-99M D, 1 HMPAO IN HEALTHY HUMAN SUBJECTS. Clinical Nuclear Medicine 1989, 14: 230. DOI: 10.1097/00003072-198903000-00025.
- SEIBYL J, KRYSTAL J, PRICE L, CHARNEY D. Use of Yohimbine to Counteract Nortriptyline-Induced Orthostatic Hypotension. Journal Of Clinical Psychopharmacology 1989, 9: 67-68. PMID: 2708559, DOI: 10.1097/00004714-198902000-00026.
- Krystal J, Walker M, Heninger G. Intermittent naloxone attenuates the development of physical dependence on methadone in rhesus monkeys. European Journal Of Pharmacology 1989, 160: 331-338. PMID: 2540995, DOI: 10.1016/0014-2999(89)90088-5.
- Krystal J. Psychopharmacology: The Third Generation of Progress. The Yale Journal Of Biology And Medicine 1989, 62: 554-555. PMCID: PMC2589180.
- Krystal J, Woods S, Levesque M, Heninger C, Heninger G. The effects of carbon dioxide inhalation of plasma MHPG, plasma hormones respiratory rate, and behavior in the Rhesus monkey. Life Sciences 1989, 45: 1657-1663. PMID: 2511388, DOI: 10.1016/0024-3205(89)90275-0.
- Woods S, Krystal J, Heninger G, Charney D. Effects of alprazolam and clonidine on carbon dioxide-induced increases in anxiety ratings in healthy human subjects. Life Sciences 1989, 45: 233-242. PMID: 2503670, DOI: 10.1016/0024-3205(89)90255-5.
- Krystal J, Kosten T, Southwick S, Mason J, Perry B, Giller E. Neurobiological aspects of PTSD: Review of clinical and preclinical studies. Behavior Therapy 1989, 20: 177-198. DOI: 10.1016/s0005-7894(89)80068-1.
- Krystal J. Neural Plasticity. A Lifespan Approach. The Yale Journal Of Biology And Medicine 1988, 61: 478-479. PMCID: PMC2590436.
- Krystal J. Quantitative Receptor Autoradiography. The Yale Journal Of Biology And Medicine 1987, 60: 294-295. PMCID: PMC2590106.
- Krystal J. Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and Heart. The Yale Journal Of Biology And Medicine 1987, 60: 202-202. PMCID: PMC2590308.
- Krystal H. Management of alcohol withdrawal in the critically ill patient: a selected review. Henry Ford Hospital Medical Journal 1986, 34: 293. PMID: 3583798.
- Krystal J. The Psychopharmacology of Lithium. The Yale Journal Of Biology And Medicine 1986, 59: 74-75. PMCID: PMC2590046.
- van der Kolk B, Greenberg M, Boyd H, Krystal J. Inescapable shock, neurotransmitters, and addiction to trauma: Toward a psychobiology of post traumatic stress. Biological Psychiatry 1985, 20: 314-325. PMID: 2858226, DOI: 10.1016/0006-3223(85)90061-7.
- Krystal J. Monoamine Innervation of the Cerebral Cortex. The Yale Journal Of Biology And Medicine 1985, 58: 58-59. PMCID: PMC2589842.
- Krystal J. Behavioral Pharmacology: The Current Status. The Yale Journal Of Biology And Medicine 1985, 58: 197-198. PMCID: PMC2589892.
- Krystal J. Ethopharmacology: Primate Models of Neuropsychiatric Disorders. The Yale Journal Of Biology And Medicine 1984, 57: 248-250. PMCID: PMC2589821.
- Krystal J. Anorexia Nervosa: Recent Developments in Research. The Yale Journal Of Biology And Medicine 1984, 57: 442-443. PMCID: PMC2589855.
- Krystal J. Physiology of Adrenocortical Secretion. Frontiers of Hormone Research. Volume 11. The Yale Journal Of Biology And Medicine 1984, 57: 247-247. PMCID: PMC2589820.
- Krystal J. The Natural History of Alcoholism: Causes, Patterns, and Paths to Recovery. The Yale Journal Of Biology And Medicine 1983, 56: 339-340. PMCID: PMC2589638.
- Krystal J, Arnold R. Psychopharmacology of Clonidine. The Yale Journal Of Biology And Medicine 1982, 55: 543-544. PMCID: PMC2596571.
- Krystal H. Trauma: considerations of its intensity and chronicity. International Psychiatry Clinics 1971, 8: 11-28. PMID: 5148247.
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