Gilbert Moeckel, MD, PhD, FASN
Biography
Gilbert Moeckel, MD, PhD, is a pathologist who specializes in diagnosing kidney diseases. He became fascinated with the complexity of the kidney during his graduate studies after medical school. "I was attracted to medicine because of the scientific challenges," Dr. Moeckel says.
While examining a biopsy from a patient, Dr. Moeckel explains, it's important for a pathologist to think comprehensively and consider different conditions associated with the organ. "Many diseases are involved in the kidney or start from a kidney defect," he says.
When he provides a specific diagnosis a physician, Dr. Moeckel, like other pathologists, works with that patient's doctor to recommend the best course of treatment. In order to arrive at an accurate diagnosis, a pathologist "needs to have a lot of experience and a solid understanding and visual awareness of diseases."
At Yale School of Medicine, Dr. Moeckel is professor of pathology and director of the renal, or kidney, pathology and electron microscopy laboratory. His research focuses on better understanding the progression of chronic kidney disease.
Titles
- Professor of Pathology
- Director, Renal,Transplant Pathology and Electron Microscopy Laboratory, Pathology
- Director, Renal & Genitourinary Fellowship Program, Pathology
Education & Training
- FellowUniversity of Arizona (2000)
- ResidentUniversity of Arizona (1999)
- FellowUniversity of Arizona (1996)
- PhDLudwig-Maximilians-Universitat Munchen (1993)
- MDLudwig-Maximilians-Universitat Munchen (1989)
Languages Spoken
- English
- Français (French)
- Deutsch (German)
Additional Information
- Yale School of Medicine (2018 - Present): Faculty Advisory Committee to the Dean
- Yale University (2014 - 2017): Yale University HIC Committee IV
- American Society of Nephrology (2012 - 2013): Program Committee for Renal Week 2013
- American Society of Nephrology (2005): Scientific Session “Stress and Transport”, ASN Renal Week, San Francisco, CA,
- Chen PM, Wilson PC, Shyer JA, Veselits M, Steach HR, Cui C, Moeckel G, Clark MR, Craft J. Kidney tissue hypoxia dictates T cell-mediated injury in murine lupus nephritis. Science Translational Medicine 2020, 12 PMID: 32269165, PMCID: PMC8055156, DOI: 10.1126/scitranslmed.aay1620.
- Brill AL, Fischer TT, Walters JM, Marlier A, Sewanan LR, Wilson PC, Johnson EK, Moeckel G, Cantley LG, Campbell SG, Nerbonne JM, Chung HJ, Robert ME, Ehrlich BE. Polycystin 2 is increased in disease to protect against stress-induced cell death. Scientific Reports 2020, 10: 386. PMID: 31941974, PMCID: PMC6962458, DOI: 10.1038/s41598-019-57286-x.
- Han X, Vesely MD, Yang W, Sanmamed MF, Badri T, Alawa J, López-Giráldez F, Gaule P, Lee SW, Zhang JP, Nie X, Nassar A, Boto A, Flies DB, Zheng L, Kim TK, Moeckel GW, McNiff JM, Chen L. PD-1H (VISTA)-mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus. Science Translational Medicine 2019, 11 PMID: 31826980, DOI: 10.1126/scitranslmed.aax1159.
- Averdunk L, Fitzner C, Levkovich T, Leaf DE, Sobotta M, Vieten J, Ochi A, Moeckel G, Marx G, Stoppe C. Secretory Leukocyte Protease Inhibitor (SLPI)-A Novel Predictive Biomarker of Acute Kidney Injury after Cardiac Surgery: A Prospective Observational Study. Journal Of Clinical Medicine 2019, 8 PMID: 31717603, PMCID: PMC6912354, DOI: 10.3390/jcm8111931.
- Roy SF, Ko CJ, Moeckel GW, McNiff JM. Hypergranulotic dyscornification: 30 cases of a striking epithelial reaction pattern. Journal Of Cutaneous Pathology 2019, 46: 742-747. PMID: 31157457, DOI: 10.1111/cup.13522.
- Singh N, Avigan ZM, Kliegel JA, Shuch BM, Montgomery RR, Moeckel GW, Cantley LG. Development of a 2-dimensional atlas of the human kidney with imaging mass cytometry. JCI Insight 2019, 4 PMID: 31217358, PMCID: PMC6629112, DOI: 10.1172/jci.insight.129477.
- Moledina DG, Wilson FP, Pober JS, Perazella MA, Singh N, Luciano RL, Obeid W, Lin H, Kuperman M, Moeckel GW, Kashgarian M, Cantley LG, Parikh CR. Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis. JCI Insight 2019, 4 PMID: 31092735, PMCID: PMC6542610, DOI: 10.1172/jci.insight.127456.
- Landau SI, Guo X, Velazquez H, Torres R, Olson E, Garcia-Milian R, Moeckel GW, Desir GV, Safirstein R. Regulated necrosis and failed repair in cisplatin-induced chronic kidney disease. Kidney International 2019, 95: 797-814. PMID: 30904067, PMCID: PMC6543531, DOI: 10.1016/j.kint.2018.11.042.
- Cavanaugh C, Moeckel GW, Perazella MA. Telavancin-associated acute kidney injury . Clinical Nephrology 2019, 91: 187-191. PMID: 30614441, DOI: 10.5414/CN109651.
- Luciano RL, Moeckel GW. Update on the Native Kidney Biopsy: Core Curriculum 2019. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2019, 73: 404-415. PMID: 30661724, DOI: 10.1053/j.ajkd.2018.10.011.
- Gulati A, Bale AE, Dykas DJ, Bia MJ, Danovitch GM, Moeckel GW, Somlo S, Dahl NK. TREX1 Mutation Causing Autosomal Dominant Thrombotic Microangiopathy and CKD-A Novel Presentation. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2018, 72: 895-899. PMID: 29941221, DOI: 10.1053/j.ajkd.2018.05.006.
- Mansour SG, Hall IE, Reese PP, Jia Y, Thiessen-Philbrook H, Moeckel G, Weng FL, Revelo MP, Khalighi MA, Trivedi A, Doshi MD, Schröppel B, Parikh CR. Reliability of deceased-donor procurement kidney biopsy images uploaded in United Network for Organ Sharing. Clinical Transplantation 2018, 32: e13441. PMID: 30387908, PMCID: PMC6317379, DOI: 10.1111/ctr.13441.
- Lee Y, Blount KL, Dai F, Thompson S, Scher JK, Bitterman S, Droher M, Herzog EL, Moeckel G, Karihaloo A, Dahl NK. Semaphorin 7A in circulating regulatory T cells is increased in autosomal-dominant polycystic kidney disease and decreases with tolvaptan treatment. Clinical And Experimental Nephrology 2018, 22: 906-916. PMID: 29453607, DOI: 10.1007/s10157-018-1542-x.
- Stoppe C, Averdunk L, Goetzenich A, Soppert J, Marlier A, Kraemer S, Vieten J, Coburn M, Kowark A, Kim BS, Marx G, Rex S, Ochi A, Leng L, Moeckel G, Linkermann A, El Bounkari O, Zarbock A, Bernhagen J, Djudjaj S, Bucala R, Boor P. The protective role of macrophage migration inhibitory factor in acute kidney injury after cardiac surgery. Science Translational Medicine 2018, 10 PMID: 29769287, DOI: 10.1126/scitranslmed.aan4886.
- Mensah KA, Malek Pascha V, Moeckel G, Danve A. Granulomatosis With Polyangiitis in a Young Adult With Down Syndrome: Therapeutic Challenges and Clues to Immunopathogenesis. Journal Of Clinical Rheumatology : Practical Reports On Rheumatic & Musculoskeletal Diseases 2018, 24: 153-156. PMID: 29200025, DOI: 10.1097/RHU.0000000000000633.
- Wilson PC, Kashgarian M, Moeckel G. Interstitial inflammation and interstitial fibrosis and tubular atrophy predict renal survival in lupus nephritis. Clinical Kidney Journal 2018, 11: 207-218. PMID: 29644061, PMCID: PMC5888814, DOI: 10.1093/ckj/sfx093.
- Moeckel GW. Pathologic Perspectives on Acute Tubular Injury Assessment in the Kidney Biopsy. Seminars In Nephrology 2018, 38: 21-30. PMID: 29291758, DOI: 10.1016/j.semnephrol.2017.09.003.
- Ochi A, Chen D, Schulte W, Leng L, Moeckel N, Piecychna M, Averdunk L, Stoppe C, Bucala R, Moeckel G. MIF-2/D-DT enhances proximal tubular cell regeneration through SLPI- and ATF4-dependent mechanisms. American Journal Of Physiology. Renal Physiology 2017, 313: F767-F780. PMID: 28539339, PMCID: PMC6148305, DOI: 10.1152/ajprenal.00683.2016.
- Zhou H, Tian X, Tufro A, Moeckel G, Ishibe S, Goodwin J. Loss of the podocyte glucocorticoid receptor exacerbates proteinuria after injury. Scientific Reports 2017, 7: 9833. PMID: 28852159, PMCID: PMC5575043, DOI: 10.1038/s41598-017-10490-z.
- Koraishy FM, Moeckel GW, Geller DS. A case of severe nephrotoxicity associated with long-term dietary supplement use. Clinical Nephrology 2017 PMID: 28766491, PMCID: PMC5642467, DOI: 10.5414/CNCS109180.
- Li A, Fan S, Xu Y, Meng J, Shen X, Mao J, Zhang L, Zhang X, Moeckel G, Wu D, Wu G, Liang C. Rapamycin treatment dose-dependently improves the cystic kidney in a new ADPKD mouse model via the mTORC1 and cell-cycle-associated CDK1/cyclin axis. Journal Of Cellular And Molecular Medicine 2017, 21: 1619-1635. PMID: 28244683, PMCID: PMC5543471, DOI: 10.1111/jcmm.13091.
- Nakazawa D, Kumar SV, Marschner J, Desai J, Holderied A, Rath L, Kraft F, Lei Y, Fukasawa Y, Moeckel GW, Angelotti ML, Liapis H, Anders HJ. Histones and Neutrophil Extracellular Traps Enhance Tubular Necrosis and Remote Organ Injury in Ischemic AKI. Journal Of The American Society Of Nephrology : JASN 2017, 28: 1753-1768. PMID: 28073931, PMCID: PMC5461800, DOI: 10.1681/ASN.2016080925.
- Kulkarni S, Kirkiles-Smith NC, Deng YH, Formica RN, Moeckel G, Broecker V, Bow L, Tomlin R, Pober JS. Eculizumab Therapy for Chronic Antibody-Mediated Injury in Kidney Transplant Recipients: A Pilot Randomized Controlled Trial. American Journal Of Transplantation : Official Journal Of The American Society Of Transplantation And The American Society Of Transplant Surgeons 2017, 17: 682-691. PMID: 27501352, DOI: 10.1111/ajt.14001.
- Torres R, Velazquez H, Chang JJ, Levene MJ, Moeckel G, Desir GV, Safirstein R. Three-Dimensional Morphology by Multiphoton Microscopy with Clearing in a Model of Cisplatin-Induced CKD. Journal Of The American Society Of Nephrology : JASN 2016, 27: 1102-12. PMID: 26303068, PMCID: PMC4814184, DOI: 10.1681/ASN.2015010079.
- Hassan H, Tian X, Inoue K, Chai N, Liu C, Soda K, Moeckel G, Tufro A, Lee AH, Somlo S, Fedeles S, Ishibe S. Essential Role of X-Box Binding Protein-1 during Endoplasmic Reticulum Stress in Podocytes. Journal Of The American Society Of Nephrology : JASN 2016, 27: 1055-65. PMID: 26303067, PMCID: PMC4814187, DOI: 10.1681/ASN.2015020191.
- Valika AK, Jain D, Jaffe PE, Moeckel G, Brewster UC. A Nodular Foreign Body Reaction in a Dialysis Patient Receiving Long-term Treatment With Lanthanum Carbonate. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2016, 67: 128-32. PMID: 26385816, DOI: 10.1053/j.ajkd.2015.07.033.
- Stankewich MC, Moeckel GW, Ji L, Ardito T, Morrow JS. Isoforms of Spectrin and Ankyrin Reflect the Functional Topography of the Mouse Kidney. PloS One 2016, 11: e0142687. PMID: 26727517, PMCID: PMC4703142, DOI: 10.1371/journal.pone.0142687.
- Rudich DS, Yun SH, Liebling A, Silbert JE, Moeckel GW, Lesser RL. Antiphospholipid Antibody Syndrome: Raised Intracranial Pressure Without Cerebral Venous Sinus Thrombosis. Journal Of Neuro-ophthalmology : The Official Journal Of The North American Neuro-Ophthalmology Society 2015, 35: 396-9. PMID: 26049680, DOI: 10.1097/WNO.0000000000000277.
- Li A, Tian X, Zhang X, Huang S, Ma Y, Wu D, Moeckel G, Somlo S, Wu G. Human polycystin-2 transgene dose-dependently rescues ADPKD phenotypes in Pkd2 mutant mice. The American Journal Of Pathology 2015, 185: 2843-60. PMID: 26435415, PMCID: PMC4607765, DOI: 10.1016/j.ajpath.2015.06.014.
- Huen SC, Huynh L, Marlier A, Lee Y, Moeckel GW, Cantley LG. GM-CSF Promotes Macrophage Alternative Activation after Renal Ischemia/Reperfusion Injury. Journal Of The American Society Of Nephrology : JASN 2015, 26: 1334-45. PMID: 25388222, PMCID: PMC4446881, DOI: 10.1681/ASN.2014060612.
- Aggarwal PK, Veron D, Thomas DB, Siegel D, Moeckel G, Kashgarian M, Tufro A. Semaphorin3a promotes advanced diabetic nephropathy. Diabetes 2015, 64: 1743-59. PMID: 25475434, PMCID: PMC4407856, DOI: 10.2337/db14-0719.
- Castano E, Palmer MB, Vigneault C, Luciano R, Wong S, Moeckel G. Comparison of amyloid deposition in human kidney biopsies as predictor of poor patient outcome. BMC Nephrology 2015, 16: 64. PMID: 25924613, PMCID: PMC4424547, DOI: 10.1186/s12882-015-0046-0.
- Yuan A, Lee Y, Choi U, Moeckel G, Karihaloo A. Chemokine receptor Cxcr4 contributes to kidney fibrosis via multiple effectors. American Journal Of Physiology. Renal Physiology 2015, 308: F459-72. PMID: 25537742, PMCID: PMC4346747, DOI: 10.1152/ajprenal.00146.2014.
- A 25-Year-Old Man with Necrotizing IgA Nephropathy and Sub Epithelial Electron Dense DepositsFu LY and Moeckel GW. Austin J Clin Pathol 2015,2(2):1031.
- Goodwin JE, Palmer M, Pashankar F, Tufro A, Moeckel G. A 7-year-old boy with renal insufficiency and proteinuria after stem cell transplant for T-cell acute lymphoblastic leukemia. Clinical Nephrology 2014, 82: 205-10. PMID: 23391318, PMCID: PMC6990651, DOI: 10.5414/CN107767.
- Luciano RL, Castano E, Moeckel G, Perazella MA. Bile acid nephropathy in a bodybuilder abusing an anabolic androgenic steroid. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2014, 64: 473-6. PMID: 24953892, DOI: 10.1053/j.ajkd.2014.05.010.
- Veron D, Aggarwal PK, Velazquez H, Kashgarian M, Moeckel G, Tufro A. Podocyte-specific VEGF-a gain of function induces nodular glomerulosclerosis in eNOS null mice. Journal Of The American Society Of Nephrology : JASN 2014, 25: 1814-24. PMID: 24578128, PMCID: PMC4116059, DOI: 10.1681/ASN.2013070752.
- Chen D, Chen Z, Zhang Y, Park C, Al-Omari A, Moeckel GW. Role of medullary progenitor cells in epithelial cell migration and proliferation. American Journal Of Physiology. Renal Physiology 2014, 307: F64-74. PMID: 24808539, PMCID: PMC4080159, DOI: 10.1152/ajprenal.00547.2013.
- Wang L, Velazquez H, Moeckel G, Chang J, Ham A, Lee HT, Safirstein R, Desir GV. Renalase prevents AKI independent of amine oxidase activity. Journal Of The American Society Of Nephrology : JASN 2014, 25: 1226-35. PMID: 24511138, PMCID: PMC4033373, DOI: 10.1681/ASN.2013060665.
- Fretz JA, Nelson T, Velazquez H, Xi Y, Moeckel GW, Horowitz MC. Early B-cell factor 1 is an essential transcription factor for postnatal glomerular maturation. Kidney International 2014, 85: 1091-102. PMID: 24172684, PMCID: PMC4006322, DOI: 10.1038/ki.2013.433.
- Vichot AA, Formica RN, Moeckel GW. Cytomegalovirus glomerulopathy and cytomegalovirus interstitial nephritis on sequential transplant kidney biopsies. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2014, 63: 536-9. PMID: 24568687, PMCID: PMC7210789, DOI: 10.1053/j.ajkd.2013.08.021.
- Tian X, Kim JJ, Monkley SM, Gotoh N, Nandez R, Soda K, Inoue K, Balkin DM, Hassan H, Son SH, Lee Y, Moeckel G, Calderwood DA, Holzman LB, Critchley DR, Zent R, Reiser J, Ishibe S. Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance. The Journal Of Clinical Investigation 2014, 124: 1098-113. PMID: 24531545, PMCID: PMC3934159, DOI: 10.1172/JCI69778.
- Mason S, Hader C, Marlier A, Moeckel G, Cantley LG. Met activation is required for early cytoprotection after ischemic kidney injury. Journal Of The American Society Of Nephrology : JASN 2014, 25: 329-37. PMID: 24136921, PMCID: PMC3904569, DOI: 10.1681/ASN.2013050473.
- Palmer MB, Vichot AA, Cantley LG, Moeckel GW. Quantification and localization of M2 macrophages in human kidneys with acute tubular injury. International Journal Of Nephrology And Renovascular Disease 2014, 7: 415-9. PMID: 25404860, PMCID: PMC4230184, DOI: 10.2147/IJNRD.S66936.
- Lian P, Li A, Li Y, Liu H, Liang D, Hu B, Lin D, Jiang T, Moeckel G, Qin D, Wu G. Loss of polycystin-1 inhibits Bicc1 expression during mouse development. PloS One 2014, 9: e88816. PMID: 24594709, PMCID: PMC3940423, DOI: 10.1371/journal.pone.0088816.
- Jane-Wit D, Manes TD, Yi T, Qin L, Clark P, Kirkiles-Smith NC, Abrahimi P, Devalliere J, Moeckel G, Kulkarni S, Tellides G, Pober JS. Alloantibody and complement promote T cell-mediated cardiac allograft vasculopathy through noncanonical nuclear factor-κB signaling in endothelial cells. Circulation 2013, 128: 2504-16. PMID: 24045046, PMCID: PMC3885874, DOI: 10.1161/CIRCULATIONAHA.113.002972.
- Chen D, Chen Z, Park C, Centrella M, McCarthy T, Chen L, Al-Omari A, Moeckel GW. Aldosterone stimulates fibronectin synthesis in renal fibroblasts through mineralocorticoid receptor-dependent and independent mechanisms. Gene 2013, 531: 23-30. PMID: 23994292, DOI: 10.1016/j.gene.2013.08.047.
- Moeckel GW. Hypertonic stress and cell death. Focus on "Multiple cell death pathways are independently activated by lethal hypertonicity in renal epithelial cells". American Journal Of Physiology. Cell Physiology 2013, 305: C1009-10. PMID: 24005043, DOI: 10.1152/ajpcell.00263.2013.
- Shibata S, Rinehart J, Zhang J, Moeckel G, Castañeda-Bueno M, Stiegler AL, Boggon TJ, Gamba G, Lifton RP. Mineralocorticoid receptor phosphorylation regulates ligand binding and renal response to volume depletion and hyperkalemia. Cell Metabolism 2013, 18: 660-71. PMID: 24206662, PMCID: PMC3909709, DOI: 10.1016/j.cmet.2013.10.005.
- Knauf F, Asplin JR, Granja I, Schmidt IM, Moeckel GW, David RJ, Flavell RA, Aronson PS. NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy. Kidney International 2013, 84: 895-901. PMID: 23739234, PMCID: PMC3772982, DOI: 10.1038/ki.2013.207.
- Luciano RL, Moeckel G, Palmer M, Perazella MA. Babesiosis-induced acute kidney injury with prominent urinary macrophages. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2013, 62: 801-5. PMID: 23643302, DOI: 10.1053/j.ajkd.2013.02.376.
- Moeckel GW, Luciano RL, Brewster UC. Warfarin-related nephropathy in a patient with mild IgA nephropathy on dabigatran and aspirin. Clinical Kidney Journal 2013, 6: 507-9. PMID: 26120444, PMCID: PMC4438392, DOI: 10.1093/ckj/sft076.
- Huen SC, Moeckel GW, Cantley LG. Macrophage-specific deletion of transforming growth factor-β1 does not prevent renal fibrosis after severe ischemia-reperfusion or obstructive injury. American Journal Of Physiology. Renal Physiology 2013, 305: F477-84. PMID: 23761668, PMCID: PMC3891258, DOI: 10.1152/ajprenal.00624.2012.
- Manjunath V, Moeckel G, Dahl NK. Acute kidney injury in a patient with sarcoidosis: hypercalciuria and hypercalcemia leading to calcium phosphate deposition. Clinical Nephrology 2013, 80: 151-5. PMID: 23845267, DOI: 10.5414/cn107258.
- Lemaire M, Frémeaux-Bacchi V, Schaefer F, Choi M, Tang WH, Le Quintrec M, Fakhouri F, Taque S, Nobili F, Martinez F, Ji W, Overton JD, Mane SM, Nürnberg G, Altmüller J, Thiele H, Morin D, Deschenes G, Baudouin V, Llanas B, Collard L, Majid MA, Simkova E, Nürnberg P, Rioux-Leclerc N, Moeckel GW, Gubler MC, Hwa J, Loirat C, Lifton RP. Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome. Nature Genetics 2013, 45: 531-6. PMID: 23542698, PMCID: PMC3719402, DOI: 10.1038/ng.2590.
- Schmidt IM, Hall IE, Kale S, Lee S, He CH, Lee Y, Chupp GL, Moeckel GW, Lee CG, Elias JA, Parikh CR, Cantley LG. Chitinase-like protein Brp-39/YKL-40 modulates the renal response to ischemic injury and predicts delayed allograft function. Journal Of The American Society Of Nephrology : JASN 2013, 24: 309-19. PMID: 23291472, PMCID: PMC3559482, DOI: 10.1681/ASN.2012060579.
- Soda K, Balkin DM, Ferguson SM, Paradise S, Milosevic I, Giovedi S, Volpicelli-Daley L, Tian X, Wu Y, Ma H, Son SH, Zheng R, Moeckel G, Cremona O, Holzman LB, De Camilli P, Ishibe S. Role of dynamin, synaptojanin, and endophilin in podocyte foot processes. The Journal Of Clinical Investigation 2012, 122: 4401-11. PMID: 23187129, PMCID: PMC3533561, DOI: 10.1172/JCI65289.
- Zhang MZ, Yao B, Yang S, Yang H, Wang S, Fan X, Yin H, Fogo AB, Moeckel GW, Harris RC. Intrarenal dopamine inhibits progression of diabetic nephropathy. Diabetes 2012, 61: 2575-84. PMID: 22688335, PMCID: PMC3447896, DOI: 10.2337/db12-0046.
- Veron D, Villegas G, Aggarwal PK, Bertuccio C, Jimenez J, Velazquez H, Reidy K, Abrahamson DR, Moeckel G, Kashgarian M, Tufro A. Acute podocyte vascular endothelial growth factor (VEGF-A) knockdown disrupts alphaVbeta3 integrin signaling in the glomerulus. PloS One 2012, 7: e40589. PMID: 22808199, PMCID: PMC3396653, DOI: 10.1371/journal.pone.0040589.
- Chen Z, Chen D, McCarthy TL, Centrella M, Zhang Y, Moeckel GW. Inorganic phosphate stimulates fibronectin expression in renal fibroblasts. Cellular Physiology And Biochemistry : International Journal Of Experimental Cellular Physiology, Biochemistry, And Pharmacology 2012, 30: 151-9. PMID: 22759963, DOI: 10.1159/000339054.
- Hall IE, Kashgarian M, Moeckel GW, Dahl NK. Resolution of proteinuria in a patient with focal segmental glomerulosclerosis following BiPAP initiation for obesity hypoventilation syndrome. Clinical Nephrology 2012, 77: 62-5. PMID: 22185970, DOI: 10.5414/cn106859.
- Manjunath V, Moeckel GW, Mahnensmith R, Perazella MA. Proteinuria and glomerular injury associated with the anti-angiogenesis drug Vargatef™. NDT Plus 2011, 4: 430-3. PMID: 25984216, PMCID: PMC4421682, DOI: 10.1093/ndtplus/sfr064.
- Cheng H, Fan X, Moeckel GW, Harris RC. Podocyte COX-2 exacerbates diabetic nephropathy by increasing podocyte (pro)renin receptor expression. Journal Of The American Society Of Nephrology : JASN 2011, 22: 1240-51. PMID: 21737546, PMCID: PMC3137572, DOI: 10.1681/ASN.2010111149.
- Veron D, Bertuccio CA, Marlier A, Reidy K, Garcia AM, Jimenez J, Velazquez H, Kashgarian M, Moeckel GW, Tufro A. Podocyte vascular endothelial growth factor (Vegf₁₆₄) overexpression causes severe nodular glomerulosclerosis in a mouse model of type 1 diabetes. Diabetologia 2011, 54: 1227-41. PMID: 21318407, PMCID: PMC3397150, DOI: 10.1007/s00125-010-2034-z.
- Jurczak MJ, Lee HY, Birkenfeld AL, Jornayvaz FR, Frederick DW, Pongratz RL, Zhao X, Moeckel GW, Samuel VT, Whaley JM, Shulman GI, Kibbey RG. SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function. Diabetes 2011, 60: 890-8. PMID: 21357472, PMCID: PMC3046850, DOI: 10.2337/db10-1328.
- Marin EP, Moeckel G, Al-Lamki R, Bradley J, Yan Q, Wang T, Wright PL, Yu J, Sessa WC. Identification and regulation of reticulon 4B (Nogo-B) in renal tubular epithelial cells. The American Journal Of Pathology 2010, 177: 2765-73. PMID: 20971739, PMCID: PMC2993268, DOI: 10.2353/ajpath.2010.100199.
- Ni N, Moeckel GW, Kumar C. Late-onset omeprazole-associated acute interstitial nephritis. Journal Of The American Geriatrics Society 2010, 58: 2443-4. PMID: 21143456, DOI: 10.1111/j.1532-5415.2010.03194.x.
- Perazella MA, Moeckel GW. Nephrotoxicity from chemotherapeutic agents: clinical manifestations, pathobiology, and prevention/therapy. Seminars In Nephrology 2010, 30: 570-81. PMID: 21146122, DOI: 10.1016/j.semnephrol.2010.09.005.
- Seo-Mayer P, Kenney B, McNamara J, Stein J, Moeckel GW. Hematuria and decreased kidney function as initial signs of acute B-cell lymphoblastic leukemia. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2010, 56: 1001-5. PMID: 20599308, DOI: 10.1053/j.ajkd.2010.03.029.
- Gewin L, Bulus N, Mernaugh G, Moeckel G, Harris RC, Moses HL, Pozzi A, Zent R. TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis. Journal Of The American Society Of Nephrology : JASN 2010, 21: 1334-43. PMID: 20576806, PMCID: PMC2938601, DOI: 10.1681/ASN.2010020147.
- Nikiforow S, Moeckel G, Brewster UC. Anti-phospholipid antibody syndrome in the kidney. Kidney International 2010, 77: 473. PMID: 20150948, DOI: 10.1038/ki.2009.484.
- Lambert EH, Schachter LR, Altamar HO, Tikhonenkov S, Moeckel G, Miller NL, Herrell SD. A sealed bladder cuff technique during laparoscopic nephroureterectomy utilizing the LigaSure electrosurgical device: laboratory and clinical experience. Journal Of Endourology / Endourological Society 2010, 24: 327-32. PMID: 20078234, DOI: 10.1089/end.2009.0187.
- Zhang L, Chen D, Chen Z, Moeckel GW. Hypertonicity-induced mitochondrial membrane permeability in renal medullary interstitial cells: protective role of osmolytes. Cellular Physiology And Biochemistry : International Journal Of Experimental Cellular Physiology, Biochemistry, And Pharmacology 2010, 25: 753-60. PMID: 20511721, PMCID: PMC3030460, DOI: 10.1159/000315095.
- Kwon MS, Na KY, Moeckel G, Lee SD, Kwon HM. Urea promotes TonEBP expression and cellular adaptation in extreme hypertonicity. Pflügers Archiv : European Journal Of Physiology 2009, 459: 183-9. PMID: 19585141, DOI: 10.1007/s00424-009-0696-5.
- Ma H, Saenko M, Opuko A, Togawa A, Soda K, Marlier A, Moeckel GW, Cantley LG, Ishibe S. Deletion of the Met receptor in the collecting duct decreases renal repair following ureteral obstruction. Kidney International 2009, 76: 868-76. PMID: 19675527, DOI: 10.1038/ki.2009.304.
- Cheng H, Fan X, Guan Y, Moeckel GW, Zent R, Harris RC. Distinct roles for basal and induced COX-2 in podocyte injury. Journal Of The American Society Of Nephrology : JASN 2009, 20: 1953-62. PMID: 19643929, PMCID: PMC2736764, DOI: 10.1681/ASN.2009010039.
- Panzer U, Steinmetz OM, Turner JE, Meyer-Schwesinger C, von Ruffer C, Meyer TN, Zahner G, Gómez-Guerrero C, Schmid RM, Helmchen U, Moeckel GW, Wolf G, Stahl RA, Thaiss F. Resolution of renal inflammation: a new role for NF-kappaB1 (p50) in inflammatory kidney diseases. American Journal Of Physiology. Renal Physiology 2009, 297: F429-39. PMID: 19458123, DOI: 10.1152/ajprenal.90435.2008.
- Sparrow DB, Boyle SC, Sams RS, Mazuruk B, Zhang L, Moeckel GW, Dunwoodie SL, de Caestecker MP. Placental insufficiency associated with loss of Cited1 causes renal medullary dysplasia. Journal Of The American Society Of Nephrology : JASN 2009, 20: 777-86. PMID: 19297558, PMCID: PMC2663829, DOI: 10.1681/ASN.2008050547.
- Langworthy M, Zhou B, de Caestecker M, Moeckel G, Baldwin HS. NFATc1 identifies a population of proximal tubule cell progenitors. Journal Of The American Society Of Nephrology : JASN 2009, 20: 311-21. PMID: 19118153, PMCID: PMC2637056, DOI: 10.1681/ASN.2008010094.
- Srichai MB, Hao C, Davis L, Golovin A, Zhao M, Moeckel G, Dunn S, Bulus N, Harris RC, Zent R, Breyer MD. Apoptosis of the thick ascending limb results in acute kidney injury. Journal Of The American Society Of Nephrology : JASN 2008, 19: 1538-46. PMID: 18495962, PMCID: PMC2488270, DOI: 10.1681/ASN.2007101101.
- Pozzi A, Jarad G, Moeckel GW, Coffa S, Zhang X, Gewin L, Eremina V, Hudson BG, Borza DB, Harris RC, Holzman LB, Phillips CL, Fassler R, Quaggin SE, Miner JH, Zent R. Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity. Developmental Biology 2008, 316: 288-301. PMID: 18328474, PMCID: PMC2396524, DOI: 10.1016/j.ydbio.2008.01.022.
- Kim I, Fu Y, Hui K, Moeckel G, Mai W, Li C, Liang D, Zhao P, Ma J, Chen XZ, George AL, Coffey RJ, Feng ZP, Wu G. Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function. Journal Of The American Society Of Nephrology : JASN 2008, 19: 455-68. PMID: 18235088, PMCID: PMC2391052, DOI: 10.1681/ASN.2007070770.
- Cheng H, Wang S, Jo YI, Hao CM, Zhang M, Fan X, Kennedy C, Breyer MD, Moeckel GW, Harris RC. Overexpression of cyclooxygenase-2 predisposes to podocyte injury. Journal Of The American Society Of Nephrology : JASN 2007, 18: 551-9. PMID: 17202413, DOI: 10.1681/ASN.2006090990.
- Jo YI, Cheng H, Wang S, Moeckel GW, Harris RC. Puromycin induces reversible proteinuric injury in transgenic mice expressing cyclooxygenase-2 in podocytes. Nephron. Experimental Nephrology 2007, 107: e87-94. PMID: 17890881, DOI: 10.1159/000108653.
- Moeckel GW, Zhang L, Chen X, Rossini M, Zent R, Pozzi A. Role of integrin alpha1beta1 in the regulation of renal medullary osmolyte concentration. American Journal Of Physiology. Renal Physiology 2006, 290: F223-31. PMID: 16106035, DOI: 10.1152/ajprenal.00371.2004.
- Webster TM, Moeckel GW, Herrell SD. Second prize: simple method for achieving renal parenchymal hypothermia for pure laparoscopic partial nephrectomy. Journal Of Endourology / Endourological Society 2005, 19: 1075-81. PMID: 16283843, DOI: 10.1089/end.2005.19.1075.
- Lee W, Glaeser H, Smith LH, Roberts RL, Moeckel GW, Gervasini G, Leake BF, Kim RB. Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry. The Journal Of Biological Chemistry 2005, 280: 9610-7. PMID: 15632119, DOI: 10.1074/jbc.M411092200.
- Cheng H, Zhang M, Moeckel GW, Zhao Y, Wang S, Qi Z, Breyer MD, Harris RC. Expression of mediators of renal injury in the remnant kidney of ROP mice is attenuated by cyclooxygenase-2 inhibition. Nephron. Experimental Nephrology 2005, 101: e75-85. PMID: 15995341, DOI: 10.1159/000086645.
- Fisher ME, Rossini M, Simmons E, Harris RC, Moeckel G, Zent R. A woman with chronic hepatitis C infection and nephrotic syndrome who developed multiple renal lesions after interferon alfa therapy. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2004, 44: 567-73. PMID: 15332232.
- Chen X, Moeckel G, Morrow JD, Cosgrove D, Harris RC, Fogo AB, Zent R, Pozzi A. Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury. The American Journal Of Pathology 2004, 165: 617-30. PMID: 15277235, PMCID: PMC1618576, DOI: 10.1016/s0002-9440(10)63326-3.
- Lamitina ST, Morrison R, Moeckel GW, Strange K. Adaptation of the nematode Caenorhabditis elegans to extreme osmotic stress. American Journal Of Physiology. Cell Physiology 2004, 286: C785-91. PMID: 14644776, DOI: 10.1152/ajpcell.00381.2003.
- Zhang MZ, Mai W, Li C, Cho SY, Hao C, Moeckel G, Zhao R, Kim I, Wang J, Xiong H, Wang H, Sato Y, Wu Y, Nakanuma Y, Lilova M, Pei Y, Harris RC, Li S, Coffey RJ, Sun L, Wu D, Chen XZ, Breyer MD, Zhao ZJ, McKanna JA, Wu G. PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 2311-6. PMID: 14983006, PMCID: PMC356947, DOI: 10.1073/pnas.0400073101.
- Koshikawa N, Schenk S, Moeckel G, Sharabi A, Miyazaki K, Gardner H, Zent R, Quaranta V. Proteolytic processing of laminin-5 by MT1-MMP in tissues and its effects on epithelial cell morphology. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2004, 18: 364-6. PMID: 14688206, DOI: 10.1096/fj.03-0584fje.
- Wang Z, Chen JK, Wang SW, Moeckel G, Harris RC. Importance of functional EGF receptors in recovery from acute nephrotoxic injury. Journal Of The American Society Of Nephrology : JASN 2003, 14: 3147-54. PMID: 14638913, DOI: 10.1097/01.asn.0000098681.56240.1a.
- Moeckel GW, Zhang L, Fogo AB, Hao CM, Pozzi A, Breyer MD. COX2 activity promotes organic osmolyte accumulation and adaptation of renal medullary interstitial cells to hypertonic stress. The Journal Of Biological Chemistry 2003, 278: 19352-7. PMID: 12637551, DOI: 10.1074/jbc.M302209200.
- Moeckel GW, Shadman R, Fogel JM, Sadrzadeh SM. Organic osmolytes betaine, sorbitol and inositol are potent inhibitors of erythrocyte membrane ATPases. Life Sciences 2002, 71: 2413-24. PMID: 12231402, DOI: 10.1016/s0024-3205(02)02035-0.
- Cheng HF, Wang CJ, Moeckel GW, Zhang MZ, McKanna JA, Harris RC. Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of diabetes and hypertension. Kidney International 2002, 62: 929-39. PMID: 12164875, DOI: 10.1046/j.1523-1755.2002.00520.x.
- Xiong H, Chen Y, Yi Y, Tsuchiya K, Moeckel G, Cheung J, Liang D, Tham K, Xu X, Chen XZ, Pei Y, Zhao ZJ, Wu G. A novel gene encoding a TIG multiple domain protein is a positional candidate for autosomal recessive polycystic kidney disease. Genomics 2002, 80: 96-104. PMID: 12079288, DOI: 10.1006/geno.2002.6802.
- Moeckel GW, Jabs K, Fogo AB. An 11-year-old African-American girl with systemic lupus erythematosus and ANCA-negative renal vasculitis. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2002, 39: 433-8. PMID: 11840389, DOI: 10.1053/ajkd.2002.30568.
Biography
Gilbert Moeckel, MD, PhD, is a pathologist who specializes in diagnosing kidney diseases. He became fascinated with the complexity of the kidney during his graduate studies after medical school. "I was attracted to medicine because of the scientific challenges," Dr. Moeckel says.
While examining a biopsy from a patient, Dr. Moeckel explains, it's important for a pathologist to think comprehensively and consider different conditions associated with the organ. "Many diseases are involved in the kidney or start from a kidney defect," he says.
When he provides a specific diagnosis a physician, Dr. Moeckel, like other pathologists, works with that patient's doctor to recommend the best course of treatment. In order to arrive at an accurate diagnosis, a pathologist "needs to have a lot of experience and a solid understanding and visual awareness of diseases."
At Yale School of Medicine, Dr. Moeckel is professor of pathology and director of the renal, or kidney, pathology and electron microscopy laboratory. His research focuses on better understanding the progression of chronic kidney disease.
Titles
- Professor of Pathology
- Director, Renal,Transplant Pathology and Electron Microscopy Laboratory, Pathology
- Director, Renal & Genitourinary Fellowship Program, Pathology
Education & Training
- FellowUniversity of Arizona (2000)
- ResidentUniversity of Arizona (1999)
- FellowUniversity of Arizona (1996)
- PhDLudwig-Maximilians-Universitat Munchen (1993)
- MDLudwig-Maximilians-Universitat Munchen (1989)
Languages Spoken
- English
- Français (French)
- Deutsch (German)
Additional Information
- Yale School of Medicine (2018 - Present): Faculty Advisory Committee to the Dean
- Yale University (2014 - 2017): Yale University HIC Committee IV
- American Society of Nephrology (2012 - 2013): Program Committee for Renal Week 2013
- American Society of Nephrology (2005): Scientific Session “Stress and Transport”, ASN Renal Week, San Francisco, CA,
- Chen PM, Wilson PC, Shyer JA, Veselits M, Steach HR, Cui C, Moeckel G, Clark MR, Craft J. Kidney tissue hypoxia dictates T cell-mediated injury in murine lupus nephritis. Science Translational Medicine 2020, 12 PMID: 32269165, PMCID: PMC8055156, DOI: 10.1126/scitranslmed.aay1620.
- Brill AL, Fischer TT, Walters JM, Marlier A, Sewanan LR, Wilson PC, Johnson EK, Moeckel G, Cantley LG, Campbell SG, Nerbonne JM, Chung HJ, Robert ME, Ehrlich BE. Polycystin 2 is increased in disease to protect against stress-induced cell death. Scientific Reports 2020, 10: 386. PMID: 31941974, PMCID: PMC6962458, DOI: 10.1038/s41598-019-57286-x.
- Han X, Vesely MD, Yang W, Sanmamed MF, Badri T, Alawa J, López-Giráldez F, Gaule P, Lee SW, Zhang JP, Nie X, Nassar A, Boto A, Flies DB, Zheng L, Kim TK, Moeckel GW, McNiff JM, Chen L. PD-1H (VISTA)-mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus. Science Translational Medicine 2019, 11 PMID: 31826980, DOI: 10.1126/scitranslmed.aax1159.
- Averdunk L, Fitzner C, Levkovich T, Leaf DE, Sobotta M, Vieten J, Ochi A, Moeckel G, Marx G, Stoppe C. Secretory Leukocyte Protease Inhibitor (SLPI)-A Novel Predictive Biomarker of Acute Kidney Injury after Cardiac Surgery: A Prospective Observational Study. Journal Of Clinical Medicine 2019, 8 PMID: 31717603, PMCID: PMC6912354, DOI: 10.3390/jcm8111931.
- Roy SF, Ko CJ, Moeckel GW, McNiff JM. Hypergranulotic dyscornification: 30 cases of a striking epithelial reaction pattern. Journal Of Cutaneous Pathology 2019, 46: 742-747. PMID: 31157457, DOI: 10.1111/cup.13522.
- Singh N, Avigan ZM, Kliegel JA, Shuch BM, Montgomery RR, Moeckel GW, Cantley LG. Development of a 2-dimensional atlas of the human kidney with imaging mass cytometry. JCI Insight 2019, 4 PMID: 31217358, PMCID: PMC6629112, DOI: 10.1172/jci.insight.129477.
- Moledina DG, Wilson FP, Pober JS, Perazella MA, Singh N, Luciano RL, Obeid W, Lin H, Kuperman M, Moeckel GW, Kashgarian M, Cantley LG, Parikh CR. Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis. JCI Insight 2019, 4 PMID: 31092735, PMCID: PMC6542610, DOI: 10.1172/jci.insight.127456.
- Landau SI, Guo X, Velazquez H, Torres R, Olson E, Garcia-Milian R, Moeckel GW, Desir GV, Safirstein R. Regulated necrosis and failed repair in cisplatin-induced chronic kidney disease. Kidney International 2019, 95: 797-814. PMID: 30904067, PMCID: PMC6543531, DOI: 10.1016/j.kint.2018.11.042.
- Cavanaugh C, Moeckel GW, Perazella MA. Telavancin-associated acute kidney injury . Clinical Nephrology 2019, 91: 187-191. PMID: 30614441, DOI: 10.5414/CN109651.
- Luciano RL, Moeckel GW. Update on the Native Kidney Biopsy: Core Curriculum 2019. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2019, 73: 404-415. PMID: 30661724, DOI: 10.1053/j.ajkd.2018.10.011.
- Gulati A, Bale AE, Dykas DJ, Bia MJ, Danovitch GM, Moeckel GW, Somlo S, Dahl NK. TREX1 Mutation Causing Autosomal Dominant Thrombotic Microangiopathy and CKD-A Novel Presentation. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2018, 72: 895-899. PMID: 29941221, DOI: 10.1053/j.ajkd.2018.05.006.
- Mansour SG, Hall IE, Reese PP, Jia Y, Thiessen-Philbrook H, Moeckel G, Weng FL, Revelo MP, Khalighi MA, Trivedi A, Doshi MD, Schröppel B, Parikh CR. Reliability of deceased-donor procurement kidney biopsy images uploaded in United Network for Organ Sharing. Clinical Transplantation 2018, 32: e13441. PMID: 30387908, PMCID: PMC6317379, DOI: 10.1111/ctr.13441.
- Lee Y, Blount KL, Dai F, Thompson S, Scher JK, Bitterman S, Droher M, Herzog EL, Moeckel G, Karihaloo A, Dahl NK. Semaphorin 7A in circulating regulatory T cells is increased in autosomal-dominant polycystic kidney disease and decreases with tolvaptan treatment. Clinical And Experimental Nephrology 2018, 22: 906-916. PMID: 29453607, DOI: 10.1007/s10157-018-1542-x.
- Stoppe C, Averdunk L, Goetzenich A, Soppert J, Marlier A, Kraemer S, Vieten J, Coburn M, Kowark A, Kim BS, Marx G, Rex S, Ochi A, Leng L, Moeckel G, Linkermann A, El Bounkari O, Zarbock A, Bernhagen J, Djudjaj S, Bucala R, Boor P. The protective role of macrophage migration inhibitory factor in acute kidney injury after cardiac surgery. Science Translational Medicine 2018, 10 PMID: 29769287, DOI: 10.1126/scitranslmed.aan4886.
- Mensah KA, Malek Pascha V, Moeckel G, Danve A. Granulomatosis With Polyangiitis in a Young Adult With Down Syndrome: Therapeutic Challenges and Clues to Immunopathogenesis. Journal Of Clinical Rheumatology : Practical Reports On Rheumatic & Musculoskeletal Diseases 2018, 24: 153-156. PMID: 29200025, DOI: 10.1097/RHU.0000000000000633.
- Wilson PC, Kashgarian M, Moeckel G. Interstitial inflammation and interstitial fibrosis and tubular atrophy predict renal survival in lupus nephritis. Clinical Kidney Journal 2018, 11: 207-218. PMID: 29644061, PMCID: PMC5888814, DOI: 10.1093/ckj/sfx093.
- Moeckel GW. Pathologic Perspectives on Acute Tubular Injury Assessment in the Kidney Biopsy. Seminars In Nephrology 2018, 38: 21-30. PMID: 29291758, DOI: 10.1016/j.semnephrol.2017.09.003.
- Ochi A, Chen D, Schulte W, Leng L, Moeckel N, Piecychna M, Averdunk L, Stoppe C, Bucala R, Moeckel G. MIF-2/D-DT enhances proximal tubular cell regeneration through SLPI- and ATF4-dependent mechanisms. American Journal Of Physiology. Renal Physiology 2017, 313: F767-F780. PMID: 28539339, PMCID: PMC6148305, DOI: 10.1152/ajprenal.00683.2016.
- Zhou H, Tian X, Tufro A, Moeckel G, Ishibe S, Goodwin J. Loss of the podocyte glucocorticoid receptor exacerbates proteinuria after injury. Scientific Reports 2017, 7: 9833. PMID: 28852159, PMCID: PMC5575043, DOI: 10.1038/s41598-017-10490-z.
- Koraishy FM, Moeckel GW, Geller DS. A case of severe nephrotoxicity associated with long-term dietary supplement use. Clinical Nephrology 2017 PMID: 28766491, PMCID: PMC5642467, DOI: 10.5414/CNCS109180.
- Li A, Fan S, Xu Y, Meng J, Shen X, Mao J, Zhang L, Zhang X, Moeckel G, Wu D, Wu G, Liang C. Rapamycin treatment dose-dependently improves the cystic kidney in a new ADPKD mouse model via the mTORC1 and cell-cycle-associated CDK1/cyclin axis. Journal Of Cellular And Molecular Medicine 2017, 21: 1619-1635. PMID: 28244683, PMCID: PMC5543471, DOI: 10.1111/jcmm.13091.
- Nakazawa D, Kumar SV, Marschner J, Desai J, Holderied A, Rath L, Kraft F, Lei Y, Fukasawa Y, Moeckel GW, Angelotti ML, Liapis H, Anders HJ. Histones and Neutrophil Extracellular Traps Enhance Tubular Necrosis and Remote Organ Injury in Ischemic AKI. Journal Of The American Society Of Nephrology : JASN 2017, 28: 1753-1768. PMID: 28073931, PMCID: PMC5461800, DOI: 10.1681/ASN.2016080925.
- Kulkarni S, Kirkiles-Smith NC, Deng YH, Formica RN, Moeckel G, Broecker V, Bow L, Tomlin R, Pober JS. Eculizumab Therapy for Chronic Antibody-Mediated Injury in Kidney Transplant Recipients: A Pilot Randomized Controlled Trial. American Journal Of Transplantation : Official Journal Of The American Society Of Transplantation And The American Society Of Transplant Surgeons 2017, 17: 682-691. PMID: 27501352, DOI: 10.1111/ajt.14001.
- Torres R, Velazquez H, Chang JJ, Levene MJ, Moeckel G, Desir GV, Safirstein R. Three-Dimensional Morphology by Multiphoton Microscopy with Clearing in a Model of Cisplatin-Induced CKD. Journal Of The American Society Of Nephrology : JASN 2016, 27: 1102-12. PMID: 26303068, PMCID: PMC4814184, DOI: 10.1681/ASN.2015010079.
- Hassan H, Tian X, Inoue K, Chai N, Liu C, Soda K, Moeckel G, Tufro A, Lee AH, Somlo S, Fedeles S, Ishibe S. Essential Role of X-Box Binding Protein-1 during Endoplasmic Reticulum Stress in Podocytes. Journal Of The American Society Of Nephrology : JASN 2016, 27: 1055-65. PMID: 26303067, PMCID: PMC4814187, DOI: 10.1681/ASN.2015020191.
- Valika AK, Jain D, Jaffe PE, Moeckel G, Brewster UC. A Nodular Foreign Body Reaction in a Dialysis Patient Receiving Long-term Treatment With Lanthanum Carbonate. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2016, 67: 128-32. PMID: 26385816, DOI: 10.1053/j.ajkd.2015.07.033.
- Stankewich MC, Moeckel GW, Ji L, Ardito T, Morrow JS. Isoforms of Spectrin and Ankyrin Reflect the Functional Topography of the Mouse Kidney. PloS One 2016, 11: e0142687. PMID: 26727517, PMCID: PMC4703142, DOI: 10.1371/journal.pone.0142687.
- Rudich DS, Yun SH, Liebling A, Silbert JE, Moeckel GW, Lesser RL. Antiphospholipid Antibody Syndrome: Raised Intracranial Pressure Without Cerebral Venous Sinus Thrombosis. Journal Of Neuro-ophthalmology : The Official Journal Of The North American Neuro-Ophthalmology Society 2015, 35: 396-9. PMID: 26049680, DOI: 10.1097/WNO.0000000000000277.
- Li A, Tian X, Zhang X, Huang S, Ma Y, Wu D, Moeckel G, Somlo S, Wu G. Human polycystin-2 transgene dose-dependently rescues ADPKD phenotypes in Pkd2 mutant mice. The American Journal Of Pathology 2015, 185: 2843-60. PMID: 26435415, PMCID: PMC4607765, DOI: 10.1016/j.ajpath.2015.06.014.
- Huen SC, Huynh L, Marlier A, Lee Y, Moeckel GW, Cantley LG. GM-CSF Promotes Macrophage Alternative Activation after Renal Ischemia/Reperfusion Injury. Journal Of The American Society Of Nephrology : JASN 2015, 26: 1334-45. PMID: 25388222, PMCID: PMC4446881, DOI: 10.1681/ASN.2014060612.
- Aggarwal PK, Veron D, Thomas DB, Siegel D, Moeckel G, Kashgarian M, Tufro A. Semaphorin3a promotes advanced diabetic nephropathy. Diabetes 2015, 64: 1743-59. PMID: 25475434, PMCID: PMC4407856, DOI: 10.2337/db14-0719.
- Castano E, Palmer MB, Vigneault C, Luciano R, Wong S, Moeckel G. Comparison of amyloid deposition in human kidney biopsies as predictor of poor patient outcome. BMC Nephrology 2015, 16: 64. PMID: 25924613, PMCID: PMC4424547, DOI: 10.1186/s12882-015-0046-0.
- Yuan A, Lee Y, Choi U, Moeckel G, Karihaloo A. Chemokine receptor Cxcr4 contributes to kidney fibrosis via multiple effectors. American Journal Of Physiology. Renal Physiology 2015, 308: F459-72. PMID: 25537742, PMCID: PMC4346747, DOI: 10.1152/ajprenal.00146.2014.
- A 25-Year-Old Man with Necrotizing IgA Nephropathy and Sub Epithelial Electron Dense DepositsFu LY and Moeckel GW. Austin J Clin Pathol 2015,2(2):1031.
- Goodwin JE, Palmer M, Pashankar F, Tufro A, Moeckel G. A 7-year-old boy with renal insufficiency and proteinuria after stem cell transplant for T-cell acute lymphoblastic leukemia. Clinical Nephrology 2014, 82: 205-10. PMID: 23391318, PMCID: PMC6990651, DOI: 10.5414/CN107767.
- Luciano RL, Castano E, Moeckel G, Perazella MA. Bile acid nephropathy in a bodybuilder abusing an anabolic androgenic steroid. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2014, 64: 473-6. PMID: 24953892, DOI: 10.1053/j.ajkd.2014.05.010.
- Veron D, Aggarwal PK, Velazquez H, Kashgarian M, Moeckel G, Tufro A. Podocyte-specific VEGF-a gain of function induces nodular glomerulosclerosis in eNOS null mice. Journal Of The American Society Of Nephrology : JASN 2014, 25: 1814-24. PMID: 24578128, PMCID: PMC4116059, DOI: 10.1681/ASN.2013070752.
- Chen D, Chen Z, Zhang Y, Park C, Al-Omari A, Moeckel GW. Role of medullary progenitor cells in epithelial cell migration and proliferation. American Journal Of Physiology. Renal Physiology 2014, 307: F64-74. PMID: 24808539, PMCID: PMC4080159, DOI: 10.1152/ajprenal.00547.2013.
- Wang L, Velazquez H, Moeckel G, Chang J, Ham A, Lee HT, Safirstein R, Desir GV. Renalase prevents AKI independent of amine oxidase activity. Journal Of The American Society Of Nephrology : JASN 2014, 25: 1226-35. PMID: 24511138, PMCID: PMC4033373, DOI: 10.1681/ASN.2013060665.
- Fretz JA, Nelson T, Velazquez H, Xi Y, Moeckel GW, Horowitz MC. Early B-cell factor 1 is an essential transcription factor for postnatal glomerular maturation. Kidney International 2014, 85: 1091-102. PMID: 24172684, PMCID: PMC4006322, DOI: 10.1038/ki.2013.433.
- Vichot AA, Formica RN, Moeckel GW. Cytomegalovirus glomerulopathy and cytomegalovirus interstitial nephritis on sequential transplant kidney biopsies. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2014, 63: 536-9. PMID: 24568687, PMCID: PMC7210789, DOI: 10.1053/j.ajkd.2013.08.021.
- Tian X, Kim JJ, Monkley SM, Gotoh N, Nandez R, Soda K, Inoue K, Balkin DM, Hassan H, Son SH, Lee Y, Moeckel G, Calderwood DA, Holzman LB, Critchley DR, Zent R, Reiser J, Ishibe S. Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance. The Journal Of Clinical Investigation 2014, 124: 1098-113. PMID: 24531545, PMCID: PMC3934159, DOI: 10.1172/JCI69778.
- Mason S, Hader C, Marlier A, Moeckel G, Cantley LG. Met activation is required for early cytoprotection after ischemic kidney injury. Journal Of The American Society Of Nephrology : JASN 2014, 25: 329-37. PMID: 24136921, PMCID: PMC3904569, DOI: 10.1681/ASN.2013050473.
- Palmer MB, Vichot AA, Cantley LG, Moeckel GW. Quantification and localization of M2 macrophages in human kidneys with acute tubular injury. International Journal Of Nephrology And Renovascular Disease 2014, 7: 415-9. PMID: 25404860, PMCID: PMC4230184, DOI: 10.2147/IJNRD.S66936.
- Lian P, Li A, Li Y, Liu H, Liang D, Hu B, Lin D, Jiang T, Moeckel G, Qin D, Wu G. Loss of polycystin-1 inhibits Bicc1 expression during mouse development. PloS One 2014, 9: e88816. PMID: 24594709, PMCID: PMC3940423, DOI: 10.1371/journal.pone.0088816.
- Jane-Wit D, Manes TD, Yi T, Qin L, Clark P, Kirkiles-Smith NC, Abrahimi P, Devalliere J, Moeckel G, Kulkarni S, Tellides G, Pober JS. Alloantibody and complement promote T cell-mediated cardiac allograft vasculopathy through noncanonical nuclear factor-κB signaling in endothelial cells. Circulation 2013, 128: 2504-16. PMID: 24045046, PMCID: PMC3885874, DOI: 10.1161/CIRCULATIONAHA.113.002972.
- Chen D, Chen Z, Park C, Centrella M, McCarthy T, Chen L, Al-Omari A, Moeckel GW. Aldosterone stimulates fibronectin synthesis in renal fibroblasts through mineralocorticoid receptor-dependent and independent mechanisms. Gene 2013, 531: 23-30. PMID: 23994292, DOI: 10.1016/j.gene.2013.08.047.
- Moeckel GW. Hypertonic stress and cell death. Focus on "Multiple cell death pathways are independently activated by lethal hypertonicity in renal epithelial cells". American Journal Of Physiology. Cell Physiology 2013, 305: C1009-10. PMID: 24005043, DOI: 10.1152/ajpcell.00263.2013.
- Shibata S, Rinehart J, Zhang J, Moeckel G, Castañeda-Bueno M, Stiegler AL, Boggon TJ, Gamba G, Lifton RP. Mineralocorticoid receptor phosphorylation regulates ligand binding and renal response to volume depletion and hyperkalemia. Cell Metabolism 2013, 18: 660-71. PMID: 24206662, PMCID: PMC3909709, DOI: 10.1016/j.cmet.2013.10.005.
- Knauf F, Asplin JR, Granja I, Schmidt IM, Moeckel GW, David RJ, Flavell RA, Aronson PS. NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy. Kidney International 2013, 84: 895-901. PMID: 23739234, PMCID: PMC3772982, DOI: 10.1038/ki.2013.207.
- Luciano RL, Moeckel G, Palmer M, Perazella MA. Babesiosis-induced acute kidney injury with prominent urinary macrophages. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2013, 62: 801-5. PMID: 23643302, DOI: 10.1053/j.ajkd.2013.02.376.
- Moeckel GW, Luciano RL, Brewster UC. Warfarin-related nephropathy in a patient with mild IgA nephropathy on dabigatran and aspirin. Clinical Kidney Journal 2013, 6: 507-9. PMID: 26120444, PMCID: PMC4438392, DOI: 10.1093/ckj/sft076.
- Huen SC, Moeckel GW, Cantley LG. Macrophage-specific deletion of transforming growth factor-β1 does not prevent renal fibrosis after severe ischemia-reperfusion or obstructive injury. American Journal Of Physiology. Renal Physiology 2013, 305: F477-84. PMID: 23761668, PMCID: PMC3891258, DOI: 10.1152/ajprenal.00624.2012.
- Manjunath V, Moeckel G, Dahl NK. Acute kidney injury in a patient with sarcoidosis: hypercalciuria and hypercalcemia leading to calcium phosphate deposition. Clinical Nephrology 2013, 80: 151-5. PMID: 23845267, DOI: 10.5414/cn107258.
- Lemaire M, Frémeaux-Bacchi V, Schaefer F, Choi M, Tang WH, Le Quintrec M, Fakhouri F, Taque S, Nobili F, Martinez F, Ji W, Overton JD, Mane SM, Nürnberg G, Altmüller J, Thiele H, Morin D, Deschenes G, Baudouin V, Llanas B, Collard L, Majid MA, Simkova E, Nürnberg P, Rioux-Leclerc N, Moeckel GW, Gubler MC, Hwa J, Loirat C, Lifton RP. Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome. Nature Genetics 2013, 45: 531-6. PMID: 23542698, PMCID: PMC3719402, DOI: 10.1038/ng.2590.
- Schmidt IM, Hall IE, Kale S, Lee S, He CH, Lee Y, Chupp GL, Moeckel GW, Lee CG, Elias JA, Parikh CR, Cantley LG. Chitinase-like protein Brp-39/YKL-40 modulates the renal response to ischemic injury and predicts delayed allograft function. Journal Of The American Society Of Nephrology : JASN 2013, 24: 309-19. PMID: 23291472, PMCID: PMC3559482, DOI: 10.1681/ASN.2012060579.
- Soda K, Balkin DM, Ferguson SM, Paradise S, Milosevic I, Giovedi S, Volpicelli-Daley L, Tian X, Wu Y, Ma H, Son SH, Zheng R, Moeckel G, Cremona O, Holzman LB, De Camilli P, Ishibe S. Role of dynamin, synaptojanin, and endophilin in podocyte foot processes. The Journal Of Clinical Investigation 2012, 122: 4401-11. PMID: 23187129, PMCID: PMC3533561, DOI: 10.1172/JCI65289.
- Zhang MZ, Yao B, Yang S, Yang H, Wang S, Fan X, Yin H, Fogo AB, Moeckel GW, Harris RC. Intrarenal dopamine inhibits progression of diabetic nephropathy. Diabetes 2012, 61: 2575-84. PMID: 22688335, PMCID: PMC3447896, DOI: 10.2337/db12-0046.
- Veron D, Villegas G, Aggarwal PK, Bertuccio C, Jimenez J, Velazquez H, Reidy K, Abrahamson DR, Moeckel G, Kashgarian M, Tufro A. Acute podocyte vascular endothelial growth factor (VEGF-A) knockdown disrupts alphaVbeta3 integrin signaling in the glomerulus. PloS One 2012, 7: e40589. PMID: 22808199, PMCID: PMC3396653, DOI: 10.1371/journal.pone.0040589.
- Chen Z, Chen D, McCarthy TL, Centrella M, Zhang Y, Moeckel GW. Inorganic phosphate stimulates fibronectin expression in renal fibroblasts. Cellular Physiology And Biochemistry : International Journal Of Experimental Cellular Physiology, Biochemistry, And Pharmacology 2012, 30: 151-9. PMID: 22759963, DOI: 10.1159/000339054.
- Hall IE, Kashgarian M, Moeckel GW, Dahl NK. Resolution of proteinuria in a patient with focal segmental glomerulosclerosis following BiPAP initiation for obesity hypoventilation syndrome. Clinical Nephrology 2012, 77: 62-5. PMID: 22185970, DOI: 10.5414/cn106859.
- Manjunath V, Moeckel GW, Mahnensmith R, Perazella MA. Proteinuria and glomerular injury associated with the anti-angiogenesis drug Vargatef™. NDT Plus 2011, 4: 430-3. PMID: 25984216, PMCID: PMC4421682, DOI: 10.1093/ndtplus/sfr064.
- Cheng H, Fan X, Moeckel GW, Harris RC. Podocyte COX-2 exacerbates diabetic nephropathy by increasing podocyte (pro)renin receptor expression. Journal Of The American Society Of Nephrology : JASN 2011, 22: 1240-51. PMID: 21737546, PMCID: PMC3137572, DOI: 10.1681/ASN.2010111149.
- Veron D, Bertuccio CA, Marlier A, Reidy K, Garcia AM, Jimenez J, Velazquez H, Kashgarian M, Moeckel GW, Tufro A. Podocyte vascular endothelial growth factor (Vegf₁₆₄) overexpression causes severe nodular glomerulosclerosis in a mouse model of type 1 diabetes. Diabetologia 2011, 54: 1227-41. PMID: 21318407, PMCID: PMC3397150, DOI: 10.1007/s00125-010-2034-z.
- Jurczak MJ, Lee HY, Birkenfeld AL, Jornayvaz FR, Frederick DW, Pongratz RL, Zhao X, Moeckel GW, Samuel VT, Whaley JM, Shulman GI, Kibbey RG. SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function. Diabetes 2011, 60: 890-8. PMID: 21357472, PMCID: PMC3046850, DOI: 10.2337/db10-1328.
- Marin EP, Moeckel G, Al-Lamki R, Bradley J, Yan Q, Wang T, Wright PL, Yu J, Sessa WC. Identification and regulation of reticulon 4B (Nogo-B) in renal tubular epithelial cells. The American Journal Of Pathology 2010, 177: 2765-73. PMID: 20971739, PMCID: PMC2993268, DOI: 10.2353/ajpath.2010.100199.
- Ni N, Moeckel GW, Kumar C. Late-onset omeprazole-associated acute interstitial nephritis. Journal Of The American Geriatrics Society 2010, 58: 2443-4. PMID: 21143456, DOI: 10.1111/j.1532-5415.2010.03194.x.
- Perazella MA, Moeckel GW. Nephrotoxicity from chemotherapeutic agents: clinical manifestations, pathobiology, and prevention/therapy. Seminars In Nephrology 2010, 30: 570-81. PMID: 21146122, DOI: 10.1016/j.semnephrol.2010.09.005.
- Seo-Mayer P, Kenney B, McNamara J, Stein J, Moeckel GW. Hematuria and decreased kidney function as initial signs of acute B-cell lymphoblastic leukemia. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2010, 56: 1001-5. PMID: 20599308, DOI: 10.1053/j.ajkd.2010.03.029.
- Gewin L, Bulus N, Mernaugh G, Moeckel G, Harris RC, Moses HL, Pozzi A, Zent R. TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis. Journal Of The American Society Of Nephrology : JASN 2010, 21: 1334-43. PMID: 20576806, PMCID: PMC2938601, DOI: 10.1681/ASN.2010020147.
- Nikiforow S, Moeckel G, Brewster UC. Anti-phospholipid antibody syndrome in the kidney. Kidney International 2010, 77: 473. PMID: 20150948, DOI: 10.1038/ki.2009.484.
- Lambert EH, Schachter LR, Altamar HO, Tikhonenkov S, Moeckel G, Miller NL, Herrell SD. A sealed bladder cuff technique during laparoscopic nephroureterectomy utilizing the LigaSure electrosurgical device: laboratory and clinical experience. Journal Of Endourology / Endourological Society 2010, 24: 327-32. PMID: 20078234, DOI: 10.1089/end.2009.0187.
- Zhang L, Chen D, Chen Z, Moeckel GW. Hypertonicity-induced mitochondrial membrane permeability in renal medullary interstitial cells: protective role of osmolytes. Cellular Physiology And Biochemistry : International Journal Of Experimental Cellular Physiology, Biochemistry, And Pharmacology 2010, 25: 753-60. PMID: 20511721, PMCID: PMC3030460, DOI: 10.1159/000315095.
- Kwon MS, Na KY, Moeckel G, Lee SD, Kwon HM. Urea promotes TonEBP expression and cellular adaptation in extreme hypertonicity. Pflügers Archiv : European Journal Of Physiology 2009, 459: 183-9. PMID: 19585141, DOI: 10.1007/s00424-009-0696-5.
- Ma H, Saenko M, Opuko A, Togawa A, Soda K, Marlier A, Moeckel GW, Cantley LG, Ishibe S. Deletion of the Met receptor in the collecting duct decreases renal repair following ureteral obstruction. Kidney International 2009, 76: 868-76. PMID: 19675527, DOI: 10.1038/ki.2009.304.
- Cheng H, Fan X, Guan Y, Moeckel GW, Zent R, Harris RC. Distinct roles for basal and induced COX-2 in podocyte injury. Journal Of The American Society Of Nephrology : JASN 2009, 20: 1953-62. PMID: 19643929, PMCID: PMC2736764, DOI: 10.1681/ASN.2009010039.
- Panzer U, Steinmetz OM, Turner JE, Meyer-Schwesinger C, von Ruffer C, Meyer TN, Zahner G, Gómez-Guerrero C, Schmid RM, Helmchen U, Moeckel GW, Wolf G, Stahl RA, Thaiss F. Resolution of renal inflammation: a new role for NF-kappaB1 (p50) in inflammatory kidney diseases. American Journal Of Physiology. Renal Physiology 2009, 297: F429-39. PMID: 19458123, DOI: 10.1152/ajprenal.90435.2008.
- Sparrow DB, Boyle SC, Sams RS, Mazuruk B, Zhang L, Moeckel GW, Dunwoodie SL, de Caestecker MP. Placental insufficiency associated with loss of Cited1 causes renal medullary dysplasia. Journal Of The American Society Of Nephrology : JASN 2009, 20: 777-86. PMID: 19297558, PMCID: PMC2663829, DOI: 10.1681/ASN.2008050547.
- Langworthy M, Zhou B, de Caestecker M, Moeckel G, Baldwin HS. NFATc1 identifies a population of proximal tubule cell progenitors. Journal Of The American Society Of Nephrology : JASN 2009, 20: 311-21. PMID: 19118153, PMCID: PMC2637056, DOI: 10.1681/ASN.2008010094.
- Srichai MB, Hao C, Davis L, Golovin A, Zhao M, Moeckel G, Dunn S, Bulus N, Harris RC, Zent R, Breyer MD. Apoptosis of the thick ascending limb results in acute kidney injury. Journal Of The American Society Of Nephrology : JASN 2008, 19: 1538-46. PMID: 18495962, PMCID: PMC2488270, DOI: 10.1681/ASN.2007101101.
- Pozzi A, Jarad G, Moeckel GW, Coffa S, Zhang X, Gewin L, Eremina V, Hudson BG, Borza DB, Harris RC, Holzman LB, Phillips CL, Fassler R, Quaggin SE, Miner JH, Zent R. Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity. Developmental Biology 2008, 316: 288-301. PMID: 18328474, PMCID: PMC2396524, DOI: 10.1016/j.ydbio.2008.01.022.
- Kim I, Fu Y, Hui K, Moeckel G, Mai W, Li C, Liang D, Zhao P, Ma J, Chen XZ, George AL, Coffey RJ, Feng ZP, Wu G. Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function. Journal Of The American Society Of Nephrology : JASN 2008, 19: 455-68. PMID: 18235088, PMCID: PMC2391052, DOI: 10.1681/ASN.2007070770.
- Cheng H, Wang S, Jo YI, Hao CM, Zhang M, Fan X, Kennedy C, Breyer MD, Moeckel GW, Harris RC. Overexpression of cyclooxygenase-2 predisposes to podocyte injury. Journal Of The American Society Of Nephrology : JASN 2007, 18: 551-9. PMID: 17202413, DOI: 10.1681/ASN.2006090990.
- Jo YI, Cheng H, Wang S, Moeckel GW, Harris RC. Puromycin induces reversible proteinuric injury in transgenic mice expressing cyclooxygenase-2 in podocytes. Nephron. Experimental Nephrology 2007, 107: e87-94. PMID: 17890881, DOI: 10.1159/000108653.
- Moeckel GW, Zhang L, Chen X, Rossini M, Zent R, Pozzi A. Role of integrin alpha1beta1 in the regulation of renal medullary osmolyte concentration. American Journal Of Physiology. Renal Physiology 2006, 290: F223-31. PMID: 16106035, DOI: 10.1152/ajprenal.00371.2004.
- Webster TM, Moeckel GW, Herrell SD. Second prize: simple method for achieving renal parenchymal hypothermia for pure laparoscopic partial nephrectomy. Journal Of Endourology / Endourological Society 2005, 19: 1075-81. PMID: 16283843, DOI: 10.1089/end.2005.19.1075.
- Lee W, Glaeser H, Smith LH, Roberts RL, Moeckel GW, Gervasini G, Leake BF, Kim RB. Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry. The Journal Of Biological Chemistry 2005, 280: 9610-7. PMID: 15632119, DOI: 10.1074/jbc.M411092200.
- Cheng H, Zhang M, Moeckel GW, Zhao Y, Wang S, Qi Z, Breyer MD, Harris RC. Expression of mediators of renal injury in the remnant kidney of ROP mice is attenuated by cyclooxygenase-2 inhibition. Nephron. Experimental Nephrology 2005, 101: e75-85. PMID: 15995341, DOI: 10.1159/000086645.
- Fisher ME, Rossini M, Simmons E, Harris RC, Moeckel G, Zent R. A woman with chronic hepatitis C infection and nephrotic syndrome who developed multiple renal lesions after interferon alfa therapy. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2004, 44: 567-73. PMID: 15332232.
- Chen X, Moeckel G, Morrow JD, Cosgrove D, Harris RC, Fogo AB, Zent R, Pozzi A. Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury. The American Journal Of Pathology 2004, 165: 617-30. PMID: 15277235, PMCID: PMC1618576, DOI: 10.1016/s0002-9440(10)63326-3.
- Lamitina ST, Morrison R, Moeckel GW, Strange K. Adaptation of the nematode Caenorhabditis elegans to extreme osmotic stress. American Journal Of Physiology. Cell Physiology 2004, 286: C785-91. PMID: 14644776, DOI: 10.1152/ajpcell.00381.2003.
- Zhang MZ, Mai W, Li C, Cho SY, Hao C, Moeckel G, Zhao R, Kim I, Wang J, Xiong H, Wang H, Sato Y, Wu Y, Nakanuma Y, Lilova M, Pei Y, Harris RC, Li S, Coffey RJ, Sun L, Wu D, Chen XZ, Breyer MD, Zhao ZJ, McKanna JA, Wu G. PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 2311-6. PMID: 14983006, PMCID: PMC356947, DOI: 10.1073/pnas.0400073101.
- Koshikawa N, Schenk S, Moeckel G, Sharabi A, Miyazaki K, Gardner H, Zent R, Quaranta V. Proteolytic processing of laminin-5 by MT1-MMP in tissues and its effects on epithelial cell morphology. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2004, 18: 364-6. PMID: 14688206, DOI: 10.1096/fj.03-0584fje.
- Wang Z, Chen JK, Wang SW, Moeckel G, Harris RC. Importance of functional EGF receptors in recovery from acute nephrotoxic injury. Journal Of The American Society Of Nephrology : JASN 2003, 14: 3147-54. PMID: 14638913, DOI: 10.1097/01.asn.0000098681.56240.1a.
- Moeckel GW, Zhang L, Fogo AB, Hao CM, Pozzi A, Breyer MD. COX2 activity promotes organic osmolyte accumulation and adaptation of renal medullary interstitial cells to hypertonic stress. The Journal Of Biological Chemistry 2003, 278: 19352-7. PMID: 12637551, DOI: 10.1074/jbc.M302209200.
- Moeckel GW, Shadman R, Fogel JM, Sadrzadeh SM. Organic osmolytes betaine, sorbitol and inositol are potent inhibitors of erythrocyte membrane ATPases. Life Sciences 2002, 71: 2413-24. PMID: 12231402, DOI: 10.1016/s0024-3205(02)02035-0.
- Cheng HF, Wang CJ, Moeckel GW, Zhang MZ, McKanna JA, Harris RC. Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of diabetes and hypertension. Kidney International 2002, 62: 929-39. PMID: 12164875, DOI: 10.1046/j.1523-1755.2002.00520.x.
- Xiong H, Chen Y, Yi Y, Tsuchiya K, Moeckel G, Cheung J, Liang D, Tham K, Xu X, Chen XZ, Pei Y, Zhao ZJ, Wu G. A novel gene encoding a TIG multiple domain protein is a positional candidate for autosomal recessive polycystic kidney disease. Genomics 2002, 80: 96-104. PMID: 12079288, DOI: 10.1006/geno.2002.6802.
- Moeckel GW, Jabs K, Fogo AB. An 11-year-old African-American girl with systemic lupus erythematosus and ANCA-negative renal vasculitis. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2002, 39: 433-8. PMID: 11840389, DOI: 10.1053/ajkd.2002.30568.