1
Yale Emergency Medicine
Yale New Haven Shoreline Medical Center
111 Goose Lane
Guilford, CT 06437
1 of 2
- Yale Emergency MedicineYale New Haven Shoreline Medical Center111 Goose LaneGuilford, CT 06437
- Yale Emergency MedicineYale New Haven Hospital20 York StreetNew Haven, CT 06510
Basmah Safdar, MD, FACEP
Emergency Medicine
Patient type treated
Child, Adult
Accepting new patients
Yes
Referral required
Not Applicable
Board Certified in
Emergency Medicine
Titles
- Associate Professor of Emergency Medicine
- Vice Chair for Faculty Affairs and Development, Emergency Medicine
- Co-Chair, Chest Pain Center
Education & Training
- MScHarvard University, Cardiovascular Epidemiology (2013)
- ResidentYale-New Haven Hospital (2004)
- Chief ResidentYale New Haven Hospital (2004)
- MDAga Khan University (1999)
Languages Spoken
- English
- हिन्दी (Hindi)
- اردو (Urdu)
Additional Information
Honors & Recognitions
- AWAEM Midcareer Award: Society of Academic Emergency Medicine (2020)
- Leadership Award: Academy for Women in Emergency Medicine (2014)
- Best Clinical Science Research Award, Resident Category: Society of Academic Emergency Medicine (2005)
Board Certifications
- AB of Emergency Medicine, Emergency Medicine (2005, recertified: 2016)
Publications
- Murugiah K, Chen L, Dreyer RP, Bouras G, Safdar B, Lu Y, Spatz ES, Gupta A, Khera R, Ng VG, Bueno H, Tweet MS, Spertus JA, Hayes SN, Lansky A, Krumholz HM. Depression and Perceived Stress After Spontaneous Coronary Artery Dissection and Comparison With Other Acute Myocardial Infarction (the VIRGO Experience). The American Journal Of Cardiology 2022, 173: 33-38. PMID: 35365290, PMCID: PMC9133198, DOI: 10.1016/j.amjcard.2022.03.005.
- Madsen TE, Heron S, Lall MD, Blomkalns A, Arbelaez C, Lopez B, Lin M, Rounds K, Sethuraman KN, Safdar B. Institutional solutions addressing disparities in compensation and advancement of emergency medicine physicians: A critical appraisal of gaps and associated recommendations. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2022, 29: 710-718. PMID: 35064998, DOI: 10.1111/acem.14452.
- Safdar B, Mori M, Nowroozpoor A, Geirsson A, D'Onofrio G, Mangi AA. Clinical Profile and Sex-Specific Recovery With Cardiac Rehabilitation After Coronary Artery Bypass Grafting Surgery. Clinical Therapeutics 2022, 44: 846-858. PMID: 35570056, DOI: 10.1016/j.clinthera.2022.04.002.
- Banco D, Chang J, Talmor N, Wadhera P, Mukhopadhyay A, Lu X, Dong S, Lu Y, Betensky RA, Blecker S, Safdar B, Reynolds HR. Sex and Race Differences in the Evaluation and Treatment of Young Adults Presenting to the Emergency Department With Chest Pain. Journal Of The American Heart Association 2022, 11: e024199. PMID: 35506534, PMCID: PMC9238573, DOI: 10.1161/JAHA.121.024199.
- Safdar B. Influence of Sex and Gender on Lifestyle Interventions for Cardiovascular Disease. Clinical Therapeutics 2022, 44: 8-10. PMID: 34973826, DOI: 10.1016/j.clinthera.2021.12.004.
- Safdar B, Wang M, Guo X, Cha C, Chun HJ, Deng Y, Dziura J, El-Khoury JM, Gorelick F, Ko AI, Lee AI, Safirstein R, Simonov M, Zhou B, Desir GV. Association of renalase with clinical outcomes in hospitalized patients with COVID-19. PloS One 2022, 17: e0264178. PMID: 35259186, PMCID: PMC8903289, DOI: 10.1371/journal.pone.0264178.
- Murugiah K, Chen L, Dreyer RP, Bouras G, Safdar B, Khera R, Lu Y, Spatz ES, Ng VG, Gupta A, Bueno H, Tweet MS, Spertus JA, Hayes SN, Lansky A, Krumholz HM. Health status outcomes after spontaneous coronary artery dissection and comparison with other acute myocardial infarction: The VIRGO experience. PloS One 2022, 17: e0265624. PMID: 35320296, PMCID: PMC8942215, DOI: 10.1371/journal.pone.0265624.
- Shimokawa H, Suda A, Takahashi J, Berry C, Camici PG, Crea F, Escaned J, Ford T, Yii E, Kaski JC, Kiyooka T, Mehta PK, Ong P, Ozaki Y, Pepine C, Rimoldi O, Safdar B, Sechtem U, Tsujita K, Yasuda S, Beltrame JF, Merz CNB. Clinical characteristics and prognosis of patients with microvascular angina: an international and prospective cohort study by the Coronary Vasomotor Disorders International Study (COVADIS) Group. European Heart Journal 2021, 42: 4592-4600. PMID: 34038937, PMCID: PMC8633728, DOI: 10.1093/eurheartj/ehab282.
- Gaeta M, Nowroozpoor A, Dziura J, D'Onofrio G, Sinusas AJ, Safdar B. Use of peripheral arterial tonometry in detection of abnormal coronary flow reserve. Microvascular Research 2021, 138: 104223. PMID: 34256085, DOI: 10.1016/j.mvr.2021.104223.
- Nowroozpoor A, Gutterman D, Safdar B. Is microvascular dysfunction a systemic disorder with common biomarkers found in the heart, brain, and kidneys? - A scoping review. Microvascular Research 2021, 134: 104123. PMID: 33333140, DOI: 10.1016/j.mvr.2020.104123.
- Wolfe J, Safdar B, Madsen TE, Sethuraman KN, Becker B, Greenberg MR, McGregor AJ. Sex- or Gender-specific Differences in the Clinical Presentation, Outcome, and Treatment of SARS-CoV-2. Clinical Therapeutics 2021, 43: 557-571.e1. PMID: 33583576, PMCID: PMC7833665, DOI: 10.1016/j.clinthera.2021.01.015.
- Suda A, Takahashi J, Beltrame JF, Berry C, Camici PG, Crea F, Escaned J, Ford T, Carlos Kaski J, Kiyooka T, Metha PK, Ong P, Ozaki Y, Pepine C, Rimoldi O, Safdar B, Sechtem U, Tsujita K, Yii E, Noel Bairey Merz C, Shimokawa H. International prospective cohort study of microvascular angina - Rationale and design. International Journal Of Cardiology. Heart & Vasculature 2020, 31: 100630. PMID: 32984497, PMCID: PMC7494778, DOI: 10.1016/j.ijcha.2020.100630.
- Pendyal A, Rothenberg C, Scofi JE, Krumholz HM, Safdar B, Dreyer RP, Venkatesh AK. National Trends in Emergency Department Care Processes for Acute Myocardial Infarction in the United States, 2005 to 2015. Journal Of The American Heart Association 2020, 9: e017208. PMID: 33047624, PMCID: PMC7763391, DOI: 10.1161/JAHA.120.017208.
- Mehta LS, Warnes CA, Bradley E, Burton T, Economy K, Mehran R, Safdar B, Sharma G, Wood M, Valente AM, Santos Volgman A. Cardiovascular Considerations in Caring for Pregnant Patients: A Scientific Statement From the American Heart Association. Circulation 2020, 141: e884-e903. PMID: 32362133, DOI: 10.1161/CIR.0000000000000772.
- Nowroozpoor A, Gutterman D, Safdar B. Utility of discovery approach using proteomics to create a biomarker profile for coronary microvascular dysfunction. Microvascular Research 2020, 129: 103985. PMID: 32007502, DOI: 10.1016/j.mvr.2020.103985.
- Fodeh S, Li T, Jarad H, Safdar B. Classification of Patients with Coronary Microvascular Dysfunction. IEEE/ACM Transactions On Computational Biology And Bioinformatics / IEEE, ACM 2020, 17: 704-711. PMID: 31056516, DOI: 10.1109/TCBB.2019.2914442.
- Ong P, Safdar B, Seitz A, Hubert A, Beltrame J, Prescott E. Diagnosis of coronary microvascular dysfunction in the clinic. Cardiovascular Research 2020, 116: 841-855. PMID: 31904824, DOI: 10.1093/cvr/cvz339.
- Safdar B, Mangi AA. Survival of the Fittest: Impact of Cardiorespiratory Fitness on Outcomes in Men and Women with Cardiovascular Disease. Clinical Therapeutics 2020, 42: 385-392. PMID: 32088022, DOI: 10.1016/j.clinthera.2020.01.014.
- Solnick RE, Peyton K, Kraft-Todd G, Safdar B. Effect of Physician Gender and Race on Simulated Patients' Ratings and Confidence in Their Physicians: A Randomized Trial. JAMA Network Open 2020, 3: e1920511. PMID: 32083686, PMCID: PMC7043197, DOI: 10.1001/jamanetworkopen.2019.20511.
- Safdar B, D'Onofrio G, Dziura J, Russell RR, Johnson C, Sinusas AJ. Prevalence and characteristics of coronary microvascular dysfunction among chest pain patients in the emergency department. European Heart Journal. Acute Cardiovascular Care 2020, 9: 5-13. PMID: 29543037, DOI: 10.1177/2048872618764418.
- Safdar B, Guo X, Johnson C, D'Onofrio G, Dziura J, Sinusas AJ, Testani J, Rao V, Desir G. Elevated renalase levels in patients with acute coronary microvascular dysfunction - A possible biomarker for ischemia. International Journal Of Cardiology 2019, 279: 155-161. PMID: 30630613, PMCID: PMC6482834, DOI: 10.1016/j.ijcard.2018.12.061.
- Safdar B, Ona Ayala KE, Ali SS, Seifer BJ, Hong M, Greenberg MR, Choo EK, McGregor AJ. Inclusion of Sex and Gender in Emergency Medicine Research-A 2018 Update. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2019, 26: 293-302. PMID: 30637897, DOI: 10.1111/acem.13688.
- Madsen TE, Heron SL, Rounds K, Kass D, Lall M, Sethuraman KN, Arbelaez C, Blomkalns A, Safdar B. Making Promotion Count: The Gender Perspective. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2019, 26: 335-338. PMID: 30628138, DOI: 10.1111/acem.13680.
- Safdar B. Clues to Diagnose Myocardial Infarction in the Young: No Longer a Needle in the Haystack. Journal Of The American College Of Cardiology 2019, 73: 585-588. PMID: 30732712, DOI: 10.1016/j.jacc.2018.11.034.
- Safdar B, Ong P, Camici PG. Identifying Myocardial Ischemia due to Coronary Microvascular Dysfunction in the Emergency Department: Introducing a New Paradigm in Acute Chest Pain Evaluation. Clinical Therapeutics 2018, 40: 1920-1930. PMID: 30458932, DOI: 10.1016/j.clinthera.2018.09.010.
- Safdar B, Spatz ES, Dreyer RP, Beltrame JF, Lichtman JH, Spertus JA, Reynolds HR, Geda M, Bueno H, Dziura JD, Krumholz HM, D'Onofrio G. Presentation, Clinical Profile, and Prognosis of Young Patients With Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): Results From the VIRGO Study. Journal Of The American Heart Association 2018, 7 PMID: 29954744, PMCID: PMC6064896, DOI: 10.1161/JAHA.118.009174.
- Lichtman JH, Leifheit EC, Safdar B, Bao H, Krumholz HM, Lorenze NP, Daneshvar M, Spertus JA, D'Onofrio G. Sex Differences in the Presentation and Perception of Symptoms Among Young Patients With Myocardial Infarction: Evidence from the VIRGO Study (Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients). Circulation 2018, 137: 781-790. PMID: 29459463, PMCID: PMC5822747, DOI: 10.1161/CIRCULATIONAHA.117.031650.
- Current Status of Gender and Racial/Ethnic Disparities Among Academic Emergency Medicine Physicians.Madsen TE, Linden JA, Rounds K, Hsieh YH, Lopez BL, Boatright D, Garg N, Heron SL, Jameson A, Kass D, Lall MD, Melendez AM, Scheulen JJ, Sethuraman KN, Westafer LM, Safdar B. Current Status of Gender and Racial/Ethnic Disparities Among Academic Emergency Medicine Physicians. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2017, 24: 1182-1192. PMID: 28779488, DOI: 10.1111/acem.13269.
- Safdar B, D'Onofrio G, Dziura J, Russell RR, Johnson C, Sinusas AJ. Ranolazine and Microvascular Angina by PET in the Emergency Department: Results From a Pilot Randomized Controlled Trial. Clinical Therapeutics 2017, 39: 55-63. PMID: 28081848, DOI: 10.1016/j.clinthera.2016.12.002.
- Hamedani A, Safdar B, Aaronson E, Lee TH. Patient Experience Must Move Beyond Bad Apples. Annals Of Internal Medicine 2016, 165: 869-870. PMID: 27750283, DOI: 10.7326/M16-1725.
- Safdar B, Ali A, D'Onofrio G, Katz SD. Microvascular Dysfunction as Opposed to Conduit Artery Disease Explains Sex-specific Chest Pain in Emergency Department Patients With Low to Moderate Cardiac Risk. Clinical Therapeutics 2016, 38: 240-255.e1. PMID: 26778090, DOI: 10.1016/j.clinthera.2015.12.010.
- D'Onofrio G, Safdar B, Lichtman JH, Strait KM, Dreyer RP, Geda M, Spertus JA, Krumholz HM. Sex differences in reperfusion in young patients with ST-segment-elevation myocardial infarction: results from the VIRGO study. Circulation 2015, 131: 1324-32. PMID: 25792558, PMCID: PMC4652789, DOI: 10.1161/CIRCULATIONAHA.114.012293.
- Safdar B, Greenberg MR. Organization, execution and evaluation of the 2014 Academic Emergency Medicine consensus conference on Gender-Specific Research in Emergency Care - an executive summary. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2014, 21: 1307-17. PMID: 25420469, PMCID: PMC4340245, DOI: 10.1111/acem.12530.
- Safdar B, Nagurney JT, Anise A, DeVon HA, D'Onofrio G, Hess EP, Hollander JE, Legato MJ, McGregor AJ, Scott J, Tewelde S, Diercks DB. Gender-specific research for emergency diagnosis and management of ischemic heart disease: proceedings from the 2014 Academic Emergency Medicine Consensus Conference Cardiovascular Research Workgroup. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2014, 21: 1350-60. PMID: 25413468, PMCID: PMC6402042, DOI: 10.1111/acem.12527.
- Safdar B, Stolz U, Stiell IG, Cone DC, Bobrow BJ, deBoehr M, Dreyer J, Maloney J, Spaite DW. Differential survival for men and women from out-of-hospital cardiac arrest varies by age: results from the OPALS study. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2014, 21: 1503-11. PMID: 25491713, DOI: 10.1111/acem.12540.
- Safdar B, Greenberg MR, Anise A, Brown J, Conwit R, Filart R, Scott J, Choo EK. Funding mechanisms for gender-specific research: proceedings from a panel discussion at the 2014 Academic Emergency Medicine consensus conference. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2014, 21: 1329-33. PMID: 25413301, PMCID: PMC4278745, DOI: 10.1111/acem.12522.
- Safdar B, Bezek SK, Sinusas AJ, Russell RR, Klein MR, Dziura JD, D'Onofrio G. Elevated CK-MB with a normal troponin does not predict 30-day adverse cardiac events in emergency department chest pain observation unit patients. Critical Pathways In Cardiology 2014, 13: 14-9. PMID: 24526146, DOI: 10.1097/HPC.0000000000000001.
- McGregor AJ, Greenberg M, Safdar B, Seigel T, Hendrickson R, Poznanski S, Davenport M, Miner J, Choo EK. Focusing a gender lens on emergency medicine research: 2012 update. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2013, 20: 313-20. PMID: 23517266, DOI: 10.1111/acem.12085.
- Diercks DB, Mumma BE, Frank Peacock W, Hollander JE, Safdar B, Mahler SA, Miller CD, Counselman FL, Birkhahn R, Schrock J, Singer AJ, Nagurney JT. Incremental value of objective cardiac testing in addition to physician impression and serial contemporary troponin measurements in women. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2013, 20: 265-70. PMID: 23517258, PMCID: PMC3725334, DOI: 10.1111/acem.12092.
- Safdar B, Lichtman JH, D'Onofrio G. Sex and the CT: an evolving story of the heart. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2012, 19: 197-200. PMID: 22320371, DOI: 10.1111/j.1553-2712.2011.01288.x.
- Diercks DB, Peacock WF, Hollander JE, Singer AJ, Birkhahn R, Shapiro N, Glynn T, Nowack R, Safdar B, Miller CD, Lewandrowski E, Nagurney JT. Diagnostic accuracy of a point-of-care troponin I assay for acute myocardial infarction within 3 hours after presentation in early presenters to the emergency department with chest pain. American Heart Journal 2012, 163: 74-80.e4. PMID: 22172439, DOI: 10.1016/j.ahj.2011.09.028.
- Peacock WF, Nagurney J, Birkhahn R, Singer A, Shapiro N, Hollander J, Glynn T, Nowak R, Safdar B, Miller C, Peberdy M, Counselman F, Chandra A, Kosowsky J, Neuenschwander J, Schrock J, Plantholt S, Lewandrowski E, Wong V, Kupfer K, Diercks D. Myeloperoxidase in the diagnosis of acute coronary syndromes: the importance of spectrum. American Heart Journal 2011, 162: 893-9. PMID: 22093206, DOI: 10.1016/j.ahj.2011.08.017.
- Safdar B, McGregor AJ, McKee SA, Ali A, Radulescu R, Himelfarb NT, Klein MR, Mazure CM. Inclusion of gender in emergency medicine research. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2011, 18: e1-4. PMID: 21314767, DOI: 10.1111/j.1553-2712.2010.00978.x.
- Heins A, Homel P, Safdar B, Todd K. Physician race/ethnicity predicts successful emergency department analgesia. The Journal Of Pain : Official Journal Of The American Pain Society 2010, 11: 692-7. PMID: 20382572, DOI: 10.1016/j.jpain.2009.10.017.
- Safdar B, Foody JM, D'Onofrio G. Depression as modifiable coronary risk factor in the emergency department chest pain observation unit: a pilot. Critical Pathways In Cardiology 2010, 9: 82-7. PMID: 20520215, DOI: 10.1097/HPC.0b013e3181db06ef.
- Safdar B, Heins A, Homel P, Miner J, Neighbor M, DeSandre P, Todd KH. Impact of physician and patient gender on pain management in the emergency department--a multicenter study. Pain Medicine (Malden, Mass.) 2009, 10: 364-72. PMID: 18992042, DOI: 10.1111/j.1526-4637.2008.00524.x.
- Rao V, Safdar B, Parkosewich J, Lee LV, D'Onofrio G, Foody JM. Improvements in time to reperfusion: do women have an advantage? Critical Pathways In Cardiology 2009, 8: 38-42. PMID: 19258837, DOI: 10.1097/HPC.0b013e318194e443.
- Prospective Randomized Controlled Trial comparing Efficacy and Adverse events of Intravenous Ketorolac and Parenteral morphine alone and in combination in the treatment of acute renal colic.Safdar B, Degutis L, Landry K et al. (2006). Prospective Randomized Controlled Trial comparing Efficacy and Adverse events of Intravenous Ketorolac and Parenteral morphine alone and in combination in the treatment of acute renal colic. Annals of Emergency Medicine. 2006; 48(2):173-181.
Patient Care Organizations
Titles
- Associate Professor of Emergency Medicine
- Vice Chair for Faculty Affairs and Development, Emergency Medicine
- Co-Chair, Chest Pain Center
Education & Training
- MScHarvard University, Cardiovascular Epidemiology (2013)
- ResidentYale-New Haven Hospital (2004)
- Chief ResidentYale New Haven Hospital (2004)
- MDAga Khan University (1999)
Languages Spoken
- English
- हिन्दी (Hindi)
- اردو (Urdu)
Additional Information
Honors & Recognitions
- AWAEM Midcareer Award: Society of Academic Emergency Medicine (2020)
- Leadership Award: Academy for Women in Emergency Medicine (2014)
- Best Clinical Science Research Award, Resident Category: Society of Academic Emergency Medicine (2005)
Board Certifications
- AB of Emergency Medicine, Emergency Medicine (2005, recertified: 2016)
Publications
- Murugiah K, Chen L, Dreyer RP, Bouras G, Safdar B, Lu Y, Spatz ES, Gupta A, Khera R, Ng VG, Bueno H, Tweet MS, Spertus JA, Hayes SN, Lansky A, Krumholz HM. Depression and Perceived Stress After Spontaneous Coronary Artery Dissection and Comparison With Other Acute Myocardial Infarction (the VIRGO Experience). The American Journal Of Cardiology 2022, 173: 33-38. PMID: 35365290, PMCID: PMC9133198, DOI: 10.1016/j.amjcard.2022.03.005.
- Madsen TE, Heron S, Lall MD, Blomkalns A, Arbelaez C, Lopez B, Lin M, Rounds K, Sethuraman KN, Safdar B. Institutional solutions addressing disparities in compensation and advancement of emergency medicine physicians: A critical appraisal of gaps and associated recommendations. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2022, 29: 710-718. PMID: 35064998, DOI: 10.1111/acem.14452.
- Safdar B, Mori M, Nowroozpoor A, Geirsson A, D'Onofrio G, Mangi AA. Clinical Profile and Sex-Specific Recovery With Cardiac Rehabilitation After Coronary Artery Bypass Grafting Surgery. Clinical Therapeutics 2022, 44: 846-858. PMID: 35570056, DOI: 10.1016/j.clinthera.2022.04.002.
- Banco D, Chang J, Talmor N, Wadhera P, Mukhopadhyay A, Lu X, Dong S, Lu Y, Betensky RA, Blecker S, Safdar B, Reynolds HR. Sex and Race Differences in the Evaluation and Treatment of Young Adults Presenting to the Emergency Department With Chest Pain. Journal Of The American Heart Association 2022, 11: e024199. PMID: 35506534, PMCID: PMC9238573, DOI: 10.1161/JAHA.121.024199.
- Safdar B. Influence of Sex and Gender on Lifestyle Interventions for Cardiovascular Disease. Clinical Therapeutics 2022, 44: 8-10. PMID: 34973826, DOI: 10.1016/j.clinthera.2021.12.004.
- Safdar B, Wang M, Guo X, Cha C, Chun HJ, Deng Y, Dziura J, El-Khoury JM, Gorelick F, Ko AI, Lee AI, Safirstein R, Simonov M, Zhou B, Desir GV. Association of renalase with clinical outcomes in hospitalized patients with COVID-19. PloS One 2022, 17: e0264178. PMID: 35259186, PMCID: PMC8903289, DOI: 10.1371/journal.pone.0264178.
- Murugiah K, Chen L, Dreyer RP, Bouras G, Safdar B, Khera R, Lu Y, Spatz ES, Ng VG, Gupta A, Bueno H, Tweet MS, Spertus JA, Hayes SN, Lansky A, Krumholz HM. Health status outcomes after spontaneous coronary artery dissection and comparison with other acute myocardial infarction: The VIRGO experience. PloS One 2022, 17: e0265624. PMID: 35320296, PMCID: PMC8942215, DOI: 10.1371/journal.pone.0265624.
- Shimokawa H, Suda A, Takahashi J, Berry C, Camici PG, Crea F, Escaned J, Ford T, Yii E, Kaski JC, Kiyooka T, Mehta PK, Ong P, Ozaki Y, Pepine C, Rimoldi O, Safdar B, Sechtem U, Tsujita K, Yasuda S, Beltrame JF, Merz CNB. Clinical characteristics and prognosis of patients with microvascular angina: an international and prospective cohort study by the Coronary Vasomotor Disorders International Study (COVADIS) Group. European Heart Journal 2021, 42: 4592-4600. PMID: 34038937, PMCID: PMC8633728, DOI: 10.1093/eurheartj/ehab282.
- Gaeta M, Nowroozpoor A, Dziura J, D'Onofrio G, Sinusas AJ, Safdar B. Use of peripheral arterial tonometry in detection of abnormal coronary flow reserve. Microvascular Research 2021, 138: 104223. PMID: 34256085, DOI: 10.1016/j.mvr.2021.104223.
- Nowroozpoor A, Gutterman D, Safdar B. Is microvascular dysfunction a systemic disorder with common biomarkers found in the heart, brain, and kidneys? - A scoping review. Microvascular Research 2021, 134: 104123. PMID: 33333140, DOI: 10.1016/j.mvr.2020.104123.
- Wolfe J, Safdar B, Madsen TE, Sethuraman KN, Becker B, Greenberg MR, McGregor AJ. Sex- or Gender-specific Differences in the Clinical Presentation, Outcome, and Treatment of SARS-CoV-2. Clinical Therapeutics 2021, 43: 557-571.e1. PMID: 33583576, PMCID: PMC7833665, DOI: 10.1016/j.clinthera.2021.01.015.
- Suda A, Takahashi J, Beltrame JF, Berry C, Camici PG, Crea F, Escaned J, Ford T, Carlos Kaski J, Kiyooka T, Metha PK, Ong P, Ozaki Y, Pepine C, Rimoldi O, Safdar B, Sechtem U, Tsujita K, Yii E, Noel Bairey Merz C, Shimokawa H. International prospective cohort study of microvascular angina - Rationale and design. International Journal Of Cardiology. Heart & Vasculature 2020, 31: 100630. PMID: 32984497, PMCID: PMC7494778, DOI: 10.1016/j.ijcha.2020.100630.
- Pendyal A, Rothenberg C, Scofi JE, Krumholz HM, Safdar B, Dreyer RP, Venkatesh AK. National Trends in Emergency Department Care Processes for Acute Myocardial Infarction in the United States, 2005 to 2015. Journal Of The American Heart Association 2020, 9: e017208. PMID: 33047624, PMCID: PMC7763391, DOI: 10.1161/JAHA.120.017208.
- Mehta LS, Warnes CA, Bradley E, Burton T, Economy K, Mehran R, Safdar B, Sharma G, Wood M, Valente AM, Santos Volgman A. Cardiovascular Considerations in Caring for Pregnant Patients: A Scientific Statement From the American Heart Association. Circulation 2020, 141: e884-e903. PMID: 32362133, DOI: 10.1161/CIR.0000000000000772.
- Nowroozpoor A, Gutterman D, Safdar B. Utility of discovery approach using proteomics to create a biomarker profile for coronary microvascular dysfunction. Microvascular Research 2020, 129: 103985. PMID: 32007502, DOI: 10.1016/j.mvr.2020.103985.
- Fodeh S, Li T, Jarad H, Safdar B. Classification of Patients with Coronary Microvascular Dysfunction. IEEE/ACM Transactions On Computational Biology And Bioinformatics / IEEE, ACM 2020, 17: 704-711. PMID: 31056516, DOI: 10.1109/TCBB.2019.2914442.
- Ong P, Safdar B, Seitz A, Hubert A, Beltrame J, Prescott E. Diagnosis of coronary microvascular dysfunction in the clinic. Cardiovascular Research 2020, 116: 841-855. PMID: 31904824, DOI: 10.1093/cvr/cvz339.
- Safdar B, Mangi AA. Survival of the Fittest: Impact of Cardiorespiratory Fitness on Outcomes in Men and Women with Cardiovascular Disease. Clinical Therapeutics 2020, 42: 385-392. PMID: 32088022, DOI: 10.1016/j.clinthera.2020.01.014.
- Solnick RE, Peyton K, Kraft-Todd G, Safdar B. Effect of Physician Gender and Race on Simulated Patients' Ratings and Confidence in Their Physicians: A Randomized Trial. JAMA Network Open 2020, 3: e1920511. PMID: 32083686, PMCID: PMC7043197, DOI: 10.1001/jamanetworkopen.2019.20511.
- Safdar B, D'Onofrio G, Dziura J, Russell RR, Johnson C, Sinusas AJ. Prevalence and characteristics of coronary microvascular dysfunction among chest pain patients in the emergency department. European Heart Journal. Acute Cardiovascular Care 2020, 9: 5-13. PMID: 29543037, DOI: 10.1177/2048872618764418.
- Safdar B, Guo X, Johnson C, D'Onofrio G, Dziura J, Sinusas AJ, Testani J, Rao V, Desir G. Elevated renalase levels in patients with acute coronary microvascular dysfunction - A possible biomarker for ischemia. International Journal Of Cardiology 2019, 279: 155-161. PMID: 30630613, PMCID: PMC6482834, DOI: 10.1016/j.ijcard.2018.12.061.
- Safdar B, Ona Ayala KE, Ali SS, Seifer BJ, Hong M, Greenberg MR, Choo EK, McGregor AJ. Inclusion of Sex and Gender in Emergency Medicine Research-A 2018 Update. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2019, 26: 293-302. PMID: 30637897, DOI: 10.1111/acem.13688.
- Madsen TE, Heron SL, Rounds K, Kass D, Lall M, Sethuraman KN, Arbelaez C, Blomkalns A, Safdar B. Making Promotion Count: The Gender Perspective. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2019, 26: 335-338. PMID: 30628138, DOI: 10.1111/acem.13680.
- Safdar B. Clues to Diagnose Myocardial Infarction in the Young: No Longer a Needle in the Haystack. Journal Of The American College Of Cardiology 2019, 73: 585-588. PMID: 30732712, DOI: 10.1016/j.jacc.2018.11.034.
- Safdar B, Ong P, Camici PG. Identifying Myocardial Ischemia due to Coronary Microvascular Dysfunction in the Emergency Department: Introducing a New Paradigm in Acute Chest Pain Evaluation. Clinical Therapeutics 2018, 40: 1920-1930. PMID: 30458932, DOI: 10.1016/j.clinthera.2018.09.010.
- Safdar B, Spatz ES, Dreyer RP, Beltrame JF, Lichtman JH, Spertus JA, Reynolds HR, Geda M, Bueno H, Dziura JD, Krumholz HM, D'Onofrio G. Presentation, Clinical Profile, and Prognosis of Young Patients With Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): Results From the VIRGO Study. Journal Of The American Heart Association 2018, 7 PMID: 29954744, PMCID: PMC6064896, DOI: 10.1161/JAHA.118.009174.
- Lichtman JH, Leifheit EC, Safdar B, Bao H, Krumholz HM, Lorenze NP, Daneshvar M, Spertus JA, D'Onofrio G. Sex Differences in the Presentation and Perception of Symptoms Among Young Patients With Myocardial Infarction: Evidence from the VIRGO Study (Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients). Circulation 2018, 137: 781-790. PMID: 29459463, PMCID: PMC5822747, DOI: 10.1161/CIRCULATIONAHA.117.031650.
- Current Status of Gender and Racial/Ethnic Disparities Among Academic Emergency Medicine Physicians.Madsen TE, Linden JA, Rounds K, Hsieh YH, Lopez BL, Boatright D, Garg N, Heron SL, Jameson A, Kass D, Lall MD, Melendez AM, Scheulen JJ, Sethuraman KN, Westafer LM, Safdar B. Current Status of Gender and Racial/Ethnic Disparities Among Academic Emergency Medicine Physicians. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2017, 24: 1182-1192. PMID: 28779488, DOI: 10.1111/acem.13269.
- Safdar B, D'Onofrio G, Dziura J, Russell RR, Johnson C, Sinusas AJ. Ranolazine and Microvascular Angina by PET in the Emergency Department: Results From a Pilot Randomized Controlled Trial. Clinical Therapeutics 2017, 39: 55-63. PMID: 28081848, DOI: 10.1016/j.clinthera.2016.12.002.
- Hamedani A, Safdar B, Aaronson E, Lee TH. Patient Experience Must Move Beyond Bad Apples. Annals Of Internal Medicine 2016, 165: 869-870. PMID: 27750283, DOI: 10.7326/M16-1725.
- Safdar B, Ali A, D'Onofrio G, Katz SD. Microvascular Dysfunction as Opposed to Conduit Artery Disease Explains Sex-specific Chest Pain in Emergency Department Patients With Low to Moderate Cardiac Risk. Clinical Therapeutics 2016, 38: 240-255.e1. PMID: 26778090, DOI: 10.1016/j.clinthera.2015.12.010.
- D'Onofrio G, Safdar B, Lichtman JH, Strait KM, Dreyer RP, Geda M, Spertus JA, Krumholz HM. Sex differences in reperfusion in young patients with ST-segment-elevation myocardial infarction: results from the VIRGO study. Circulation 2015, 131: 1324-32. PMID: 25792558, PMCID: PMC4652789, DOI: 10.1161/CIRCULATIONAHA.114.012293.
- Safdar B, Greenberg MR. Organization, execution and evaluation of the 2014 Academic Emergency Medicine consensus conference on Gender-Specific Research in Emergency Care - an executive summary. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2014, 21: 1307-17. PMID: 25420469, PMCID: PMC4340245, DOI: 10.1111/acem.12530.
- Safdar B, Nagurney JT, Anise A, DeVon HA, D'Onofrio G, Hess EP, Hollander JE, Legato MJ, McGregor AJ, Scott J, Tewelde S, Diercks DB. Gender-specific research for emergency diagnosis and management of ischemic heart disease: proceedings from the 2014 Academic Emergency Medicine Consensus Conference Cardiovascular Research Workgroup. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2014, 21: 1350-60. PMID: 25413468, PMCID: PMC6402042, DOI: 10.1111/acem.12527.
- Safdar B, Stolz U, Stiell IG, Cone DC, Bobrow BJ, deBoehr M, Dreyer J, Maloney J, Spaite DW. Differential survival for men and women from out-of-hospital cardiac arrest varies by age: results from the OPALS study. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2014, 21: 1503-11. PMID: 25491713, DOI: 10.1111/acem.12540.
- Safdar B, Greenberg MR, Anise A, Brown J, Conwit R, Filart R, Scott J, Choo EK. Funding mechanisms for gender-specific research: proceedings from a panel discussion at the 2014 Academic Emergency Medicine consensus conference. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2014, 21: 1329-33. PMID: 25413301, PMCID: PMC4278745, DOI: 10.1111/acem.12522.
- Safdar B, Bezek SK, Sinusas AJ, Russell RR, Klein MR, Dziura JD, D'Onofrio G. Elevated CK-MB with a normal troponin does not predict 30-day adverse cardiac events in emergency department chest pain observation unit patients. Critical Pathways In Cardiology 2014, 13: 14-9. PMID: 24526146, DOI: 10.1097/HPC.0000000000000001.
- McGregor AJ, Greenberg M, Safdar B, Seigel T, Hendrickson R, Poznanski S, Davenport M, Miner J, Choo EK. Focusing a gender lens on emergency medicine research: 2012 update. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2013, 20: 313-20. PMID: 23517266, DOI: 10.1111/acem.12085.
- Diercks DB, Mumma BE, Frank Peacock W, Hollander JE, Safdar B, Mahler SA, Miller CD, Counselman FL, Birkhahn R, Schrock J, Singer AJ, Nagurney JT. Incremental value of objective cardiac testing in addition to physician impression and serial contemporary troponin measurements in women. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2013, 20: 265-70. PMID: 23517258, PMCID: PMC3725334, DOI: 10.1111/acem.12092.
- Safdar B, Lichtman JH, D'Onofrio G. Sex and the CT: an evolving story of the heart. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2012, 19: 197-200. PMID: 22320371, DOI: 10.1111/j.1553-2712.2011.01288.x.
- Diercks DB, Peacock WF, Hollander JE, Singer AJ, Birkhahn R, Shapiro N, Glynn T, Nowack R, Safdar B, Miller CD, Lewandrowski E, Nagurney JT. Diagnostic accuracy of a point-of-care troponin I assay for acute myocardial infarction within 3 hours after presentation in early presenters to the emergency department with chest pain. American Heart Journal 2012, 163: 74-80.e4. PMID: 22172439, DOI: 10.1016/j.ahj.2011.09.028.
- Peacock WF, Nagurney J, Birkhahn R, Singer A, Shapiro N, Hollander J, Glynn T, Nowak R, Safdar B, Miller C, Peberdy M, Counselman F, Chandra A, Kosowsky J, Neuenschwander J, Schrock J, Plantholt S, Lewandrowski E, Wong V, Kupfer K, Diercks D. Myeloperoxidase in the diagnosis of acute coronary syndromes: the importance of spectrum. American Heart Journal 2011, 162: 893-9. PMID: 22093206, DOI: 10.1016/j.ahj.2011.08.017.
- Safdar B, McGregor AJ, McKee SA, Ali A, Radulescu R, Himelfarb NT, Klein MR, Mazure CM. Inclusion of gender in emergency medicine research. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2011, 18: e1-4. PMID: 21314767, DOI: 10.1111/j.1553-2712.2010.00978.x.
- Heins A, Homel P, Safdar B, Todd K. Physician race/ethnicity predicts successful emergency department analgesia. The Journal Of Pain : Official Journal Of The American Pain Society 2010, 11: 692-7. PMID: 20382572, DOI: 10.1016/j.jpain.2009.10.017.
- Safdar B, Foody JM, D'Onofrio G. Depression as modifiable coronary risk factor in the emergency department chest pain observation unit: a pilot. Critical Pathways In Cardiology 2010, 9: 82-7. PMID: 20520215, DOI: 10.1097/HPC.0b013e3181db06ef.
- Safdar B, Heins A, Homel P, Miner J, Neighbor M, DeSandre P, Todd KH. Impact of physician and patient gender on pain management in the emergency department--a multicenter study. Pain Medicine (Malden, Mass.) 2009, 10: 364-72. PMID: 18992042, DOI: 10.1111/j.1526-4637.2008.00524.x.
- Rao V, Safdar B, Parkosewich J, Lee LV, D'Onofrio G, Foody JM. Improvements in time to reperfusion: do women have an advantage? Critical Pathways In Cardiology 2009, 8: 38-42. PMID: 19258837, DOI: 10.1097/HPC.0b013e318194e443.
- Prospective Randomized Controlled Trial comparing Efficacy and Adverse events of Intravenous Ketorolac and Parenteral morphine alone and in combination in the treatment of acute renal colic.Safdar B, Degutis L, Landry K et al. (2006). Prospective Randomized Controlled Trial comparing Efficacy and Adverse events of Intravenous Ketorolac and Parenteral morphine alone and in combination in the treatment of acute renal colic. Annals of Emergency Medicine. 2006; 48(2):173-181.
Patient Care Organizations
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Yale Emergency Medicine
Yale New Haven Shoreline Medical Center
111 Goose Lane
Guilford, CT 06437
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- Yale Emergency MedicineYale New Haven Shoreline Medical Center111 Goose LaneGuilford, CT 06437
- Yale Emergency MedicineYale New Haven Hospital20 York StreetNew Haven, CT 06510