Mindfulness to treat fatigue in patients with PBC

Inclusion: 

• Age 18-75 
• PBC as defined by previously published criteria [13] 
• On stable therapy with UDCA for at least 6 months before enrollment 
• PBC-40 fatigue domain score greater than 33 
• The ability to provide written consent 

Exclusion: 

• A known medical condition or metabolic disorder sufficient to explain fatigue such as anemia, 
• thyroid disease, renal failure, use of beta-blockers and untreated depression 
• Active drug or alcohol use or history of drug and/or stimulant abuse; 
• History of psychosis 
• Modification of treatment for underlying PBC in the preceding six months 
• Other serious coexistent conditions such as pre-existing advanced malignancy or severe 
• cardiopulmonary disease which would be expected to limit their life expectancy 
• Anticipated need for transplantation in one year (Mayo survival model less than 80% one-year survival 
• without transplant) or MELD above 15
• Recurrent variceal bleeding, presence of diuretic-resistant ascites, or spontaneous 
• encephalopathy