Peripartum Cardiomyopathy
Definition
Peripartum cardiomyopathy is a rare but potentially life-threatening condition characterized by the weakening of the heart muscle during the last month of pregnancy or within five months after delivery. The weakened heart muscle has a reduced ability to pump blood efficiently, which can result in heart failure and other complications. Symptoms include fatigue, heart palpitations, and shortness of breath. Risk factors include high blood pressure, diabetes, obesity, and substance use.
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- Pregnancy and Obstetrics
Randomized Evaluation of Bromocriptine in Myocardial Recovery Therapy (REBIRTH) for Peripartum Cardiomyopathy
- Ages18 years and older
- GenderFemale only
- Pregnancy and Obstetrics, Heart/Cardiovascular
Chronic Hypertension and Pregnancy (CHAP) Project (CHAP)
- Ages12 years and older
- GenderFemale only
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Cardiovascular Disease and Pregnancy Program
The Cardiovascular Disease and Pregnancy Program at Yale offers comprehensive and individualized support before, during, and after pregnancy for people with heart conditions. Our mission is to improve outcomes in pregnancy for patients with either pre-existing or newly diagnosed heart disease and ensure that pregnant patients receive appropriate and specialized risk assessment, treatment, and support. Cardiovascular disease is the number one cause of maternal mortality in the United States. While most people with pre-existing cardiovascular conditions can safely and successfully become pregnant, carry a baby to term, and breastfeed, patients with cardiovascular conditions are at higher risk of complications during pregnancy and after delivery. Pregnancy can also reveal or cause previously undiagnosed heart problems, and certain pregnancy complications can put patients at a higher risk for future cardiovascular disease. Yale’s Cardiovascular Disease and Pregnancy Program brings together cardiologists, maternal-fetal medicine specialists , nutritionists, pharmacists, lactation consultants , social workers, and family planning specialists who utilize their unique expertise to provide comprehensive patient care. Our multidisciplinary team meets regularly to create individualized care plans for each pregnant patient with heart disease. We provide care to: People with known heart disease, including congenital heart disease and acquired heart diseases, such as abnormal heart rhythms (arrhythmias), heart failure, and ischemic heart disease (coronary artery disease) People who develop cardiovascular disease or are newly diagnosed with heart disease during pregnancy (for example, peripartum cardiomyopathy) People who develop pregnancy-specific complications (including preeclampsia and related hypertensive disorders or gestational diabetes) that put them at higher risk for future cardiovascular disease Before pregnancy Contraception counseling: We provide individualized contraception counseling to patients with cardiovascular conditions to help determine the best and most reliable form of contraception for them based on a variety of factors, including specific heart conditions, interaction with other medications, and personal preferences. Comprehensive risk assessment: We provide a comprehensive risk assessment for patients with heart conditions who wish to become pregnant. We coordinate care to ensure they receive updated imaging and diagnostic studies and are on pregnancy-safe medications before they conceive. We also work closely with patients to provide nutrition and exercise guidance. Preconception counseling: We provide consultations to explore and discuss a potential pregnancy and family building. During this visit, we will answer all patient questions and develop care recommendations to support patients prior to, during, and after pregnancy. We also introduce members of the care team. During pregnancy Prenatal care management: We work wiPrenatal Genetic Diagnosis Program
The Prenatal Genetic Diagnostic Program provides expert genetic screening, testing, and counseling for parents. Our tests and services includefirst-trimester screening, chorionic villus sampling (CVS), amniocentesis, fetal blood sampling (FBS), and many others. After diagnosis, we provide counseling and connect patients to appropriate support networks to help parents adjust to and prepare for their child's special needs. In addition to pioneering the development of CVS and FBS, Yale has the most experienced team for these procedures in New England. Between 11 and 12 weeks after a woman's last menstrual period, she can instantly learn the baby's risk for Down syndrome and other abnormalities with our safe, noninvasive first-trimester risk assessment. Our team of specially-certified physicians, sonographers, and genetic counselors will provide patients with accurate information as quickly as technology allows. The procedure is simple: Patients provide a blood sample at least one week before their scheduled appointment, then visit us between weeks 11 and 14 of their pregnancy. Our comprehensive prenatal testing and genetic counseling services include: First and second trimester screenings Targeted ultrasound (formerly known as Level II ultrasound). We are equipped to perform targeted vaginal ultrasounds at an early gestational age, and provide diagnostic information early in a woman's pregnancy. Antenatal testing services. These services include nonstress testing, biophysical profiles, fetal versions, and PG gel insertions to help ensure fetal well-being throughout pregnancy. Fetal echocardiography. The Yale Fetal Cardiovascular Center is the most experienced diagnostic and treatment program of its kind in New England and provides the full range of prenatal surgical care. Prenatal ultrasound testing is typically performed during the second trimester to diagnose cardiac conditions in an unborn baby. Chorionic villus sampling (CVS). This is usually performed between the 10th and 12th weeks of pregnancy and involves the removal of a small sample of the placenta from the uterus. Amniocentesis. This is usually performed during the 15thweek of pregnancy or later, the procedure removes a sample of amniotic fluid from the uterus for evaluation. Fetal blood sampling. Fetal bloodis collected directly from the umbilical cord orfetus to test for signs of anemia and otherblooddisorders. Fetal tissue biopsy. This is typically performed between the 17thand 20thweeks of pregnancy, for patients who carry an abnormal gene for a severe skin disease to find out whether or not their fetus is similarly affected. Fetal karyotyping. This involving the collection of chorionic villi, amniotic fluid, or fetalblood to obtain and analyze chromosomes for abnormalities. Biochemical testing Fluorescence in situ hybridization (FISH) analysis. This involves laboratory testing to detect chromosomal abnormalities and other genetic mutations in a patientHigh-Risk Pregnancy Program
We provide ongoing care and management for women with a history of pregnancy risks, or current medical complications. Our providers follow patients closely from the point of referral to delivery and beyond. Patients receive individualized attention, and continuity of care is guaranteed throughout the pregnancy. We are often able to co-manage problems with our patients’ primary obstetrician. However, our High-Risk Pregnancy Program provides the full spectrum of prenatal, delivery, and postpartum care for women with high-risk pregnancies. We offer the following specialty programs: Diabetes in Pregnancy Program. This provides comprehensive services for women with diabetes before, during, and after pregnancy. Our expert team of physicians, diabetic educators, and advanced practice nurses helps initiate and manage oral hypoglycemic and insulin therapies to ensure optimal glycemic control in pregnant patients with diabetes. Our team approach has resulted in significant decreases in our patients' A1C levels, rates of fetal macrosomia (high birth weight), and incidence of pregnancy complications. Hemostasis and Thrombosis Services. Our specialists provide pregnancy management for women who suffer from thrombosis, including regular consultations and treatment with blood thinners. In addition, we provide screening and primary care, as well as treatment for other blood conditions such as hemophilia. Recurrent Pregnancy Loss Program. This is offered in conjunction with Yale’s Reproductive Endocrinology and Infertility Section. Our multidisciplinary team of pathologists, geneticists, and perinatologists uses a whole-patient approach to help couples with recurrent miscarriages and/or pregnancy losses. Women & Children’s Blood Disorders Program. This program strives to improve the quality of women and children's health by addressing disorders of blood coagulation and thrombosis during the reproductive, menopausal, fetal, neonatal, and geriatric periods of life. The program also provides patient care and management for pregnant women with preeclampsia (high blood pressure, swelling, protein in the urine).