Central Nervous System (CNS) Ganglioneuroblastoma
Definition
Central nervous system (CNS) ganglioneuroblastoma is a rare, intermediate-grade tumor that arises from the nerve cells and is characterized by a mixture of immature and mature cells. It primarily affects the central nervous system, including the brain and spinal cord, and is most commonly found in children.
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- Brain and Other Nervous System Cancers, Pediatric Cancers
A Phase 3 Randomized Study of Selumetinib Versus Carboplatin/Vincristine in Newly Diagnosed or Previously Untreated Neurofibromatosis Type 1 (NF1) Associated Low-Grade Glioma (LGG)
- Brain and Other Nervous System Cancers
A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine Versus Selumetinib (NSC# 748727) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) Not Associated With BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1)
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Pediatric Neuro-Oncology Program
The Yale Pediatric Neuro-Oncology Program provides advanced care for children, adolescents, and young adults with brain tumors. Our multidisciplinary clinic brings together a team of experts to offer the latest treatments and support for both patients and their families. Our team includes specialists in pediatric oncology, neurosurgery, neurology, endocrinology, and radiation oncology who work alongside experienced psychosocial practitioners to provide truly multidisciplinary care. We ensure that your child receives a comprehensive approach to their medical needs and overall well-being. With clinic locations in New Haven, Trumbull, and Greenwich, we offer accessible care to families across the state. We are committed to supporting your child throughout the entire treatment process, from diagnosis to recovery. We use the latest research and clinical trials to provide the most advanced treatments available. Our on-site labs and “bench to bedside“ approach mean your child can access cutting-edge therapies in state-of-the-art facilities. The Yale Pediatric Neuro-Oncology Program is proud to serve families from New England and the surrounding areas. Our focus is on your child's health and happiness, helping them thrive during and after their treatment.Central Nervous System Radiotherapy
We use radiation therapy to treat central nervous system (CNS) tumors, and to prevent or significantly delay their recurrence. CNS tumors include both low- and high-grade gliomas, meningiomas, ependymomas, germ cell tumors, and pituitary adenomas. All of our patients, both adult and pediatric, receive individualized consultations from a radiation oncologist. Our multidisciplinary team then employs a variety of state-of-the-art technologies to pinpoint, plan, and precisely deliver radiation therapy, based on each patient’s needs. We also work in collaboration with Yale Cancer Center’s Brain Tumor Program. Our Stereotactic Radiosurgery/Gamma Knife programat the YaleGamma Knife Center is the only radiosurgery unit in Connecticut dedicated to the treatment of head and neck conditions.A technique discovered more than 50 years ago, stereotactic radiosurgery remains the most accurate way to use radiation to destroy tumors in and around the brain. In our Spine Radiosurgery Program, our goal is to provide long-lasting control of pain and local disease for patients with spinal metastases. We treat patients using radiotherapy, a noninvasive, painless technique that delivers high doses of radiation to destroy tumors within or near the spine.Brain Tumor Center
The Chênevert Family Brain Tumor Center at Smilow Cancer Hospital and Yale Cancer Center is an internationally recognized leader in comprehensive and multidisciplinary clinical care, and a hub of excellence for brain tumor research. Our team of specialists is dedicated exclusively to the care of patients with all types of brain tumors, and has extensive experience with: Primary brain tumors, such as glioblastomas, astrocytomas, oligodendrogliomas, primary CNS lymphomas, and others Brain metastases and leptomeningeal metastases, which originate from other cancers in the body Other primary tumors, such as meningiomas and schwannomas Rare brain tumors including craniopharyngiomas, medulloblastomas, ependymomas pineal tumors, pituitary tumors, and others All types of neurological complications of cancer and their treatments Our expertise covers all critical components for successful care for patients with brain tumors, from comprehensive diagnostic evaluation and state-of-the-art genomic tumor profiling, to innovative treatment options and cutting-edge clinical trials. We treat all patients, whether they are newly diagnosed or have already received extensive treatment. Our expert physicians are readily available to offer second opinions for patients from all over the country, and rapidly accommodate our patients for prompt evaluation and initiation of care. We also offer an extensive program to improve patients’ quality of life before, during, and after treatment, including psychosocial support, rehabilitation for memory impairment, and other resources. Diagnosis Our experts use state-of-the-art technology to diagnose brain tumors with detailed accuracy. Three Tesla MRIs offer highly sophisticated testing, such as functional MRI, MR spectroscopy, and positron emission tomography (PET). Experienced neuroradiologists read all brain scans and evaluate the images for diagnosis. Importantly, all brain tumors that are biopsied or removed at our program undergo whole exome sequencing, the most advanced technique available for tumor characterization, which can target the vulnerabilities of individual tumors. Medical Oncology Many brain tumors require chemotherapy, targeted therapies, or other medical treatments, often combined with radiation therapy and surgery. Our team of neuro-oncologists have extensive expertise in delivering oncology treatments, with a focus on achieving optimal efficacy and safety. Each patient receives an individualized and coordinated treatment plan, taking into consideration the tumor type, molecular and genomic information on the tumor, and the patient’s own needs and choices. Additionally, our patients have access to cutting-edge Yale clinical trials exploring multiple novel strategies to fight brain cancer. Radiation Oncology Established in 1958 as one of the first Radiation Oncology departments in the country, the Yale Department of Therapeutic Radiology has played a foundational role in the national development of